{"product_id":"clascoterone-cream-1","title":"Clascoterone Cream 1%","description":"\u003cdiv class=\"pp\" lang=\"en\" itemscope itemtype=\"https:\/\/schema.org\/Product\"\u003e\n  \u003cmeta itemprop=\"name\" content=\"Winlevi Clascoterone Cream 1%\"\u003e\n  \u003cmeta itemprop=\"brand\" content=\"Winlevi\"\u003e\n  \u003cmeta itemprop=\"category\" content=\"Skincare \u0026gt; Prescription\"\u003e\n  \u003cmeta itemprop=\"countryOfOrigin\" content=\"Various\"\u003e\n\n  \u003cscript type=\"application\/ld+json\"\u003e{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@graph\": [\n    {\n      \"@type\": \"FAQPage\",\n      \"mainEntity\": [\n        {\n          \"@type\": \"Question\",\n          \"name\": \"Is Clascoterone Cream 1% (Winlevi) safe during pregnancy and breastfeeding?\",\n          \"acceptedAnswer\": {\n            \"@type\": \"Answer\",\n            \"text\": \"Safety has not been established in pregnant or breastfeeding humans. Animal studies conducted with subcutaneous administration at doses 8 to 39 times the human dose demonstrated organ malformations in rat fetuses. It is also unknown whether clascoterone passes into breast milk. The prescribing label states: \\\"It is not known if WINLEVI cream will harm your unborn baby.\\\" If you are pregnant, planning to become pregnant, or breastfeeding, you should discuss with your healthcare provider before using this product. In general, Winlevi should be classified as Caution for pregnancy — avoid unless specifically directed by a physician who has weighed the risk-benefit profile.\"\n          }\n        },\n        {\n          \"@type\": \"Question\",\n          \"name\": \"Is Clascoterone Cream 1% (Winlevi) safe for fungal acne (Malassezia folliculitis)?\",\n          \"acceptedAnswer\": {\n            \"@type\": \"Answer\",\n            \"text\": \"No — Winlevi is NOT safe for fungal acne. The formulation contains two ingredients that are known to feed Malassezia yeast: Polysorbate 80 (a polyoxyethylene sorbitan ester) and Mono and Diglycerides (fatty acid glycerol esters). Both of these can serve as a nutrient source for Malassezia furfur, the organism responsible for pityrosporum folliculitis. If you suspect you have fungal acne — characterized by small, uniform, itchy papules and pustules often on the forehead, temples, or chest — consult your dermatologist before starting Winlevi. An antifungal treatment and a Malassezia-safe acne protocol would be more appropriate.\"\n          }\n        },\n        {\n          \"@type\": \"Question\",\n          \"name\": \"Can I use Winlevi with retinol, vitamin C, AHA\/BHA, or other actives?\",\n          \"acceptedAnswer\": {\n            \"@type\": \"Answer\",\n            \"text\": \"Winlevi can be combined with other topical actives, but caution and timing are important. The prescribing information advises limiting the use of other potentially irritating topical products alongside Winlevi — specifically: medicated or abrasive soaps, cleansers with strong drying effects, high-concentration alcohol products, astringents, and products containing spices or lime. Retinoids (tretinoin, adapalene) can be used in the same regimen but ideally at different application times (e.g., Winlevi in the AM, retinoid in the PM) to minimize cumulative irritation. Similarly, AHAs, BHAs, or vitamin C serums should be used at a different time of day if concurrent irritation occurs. There are no known pharmacokinetic drug interactions; no significant effects on CYP enzymes were found in vitro. Always introduce one new active at a time and monitor for skin barrier disruption.\"\n          }\n        },\n        {\n          \"@type\": \"Question\",\n          \"name\": \"What skin type is Clascoterone Cream 1% (Winlevi) best for?\",\n          \"acceptedAnswer\": {\n            \"@type\": \"Answer\",\n            \"text\": \"Winlevi is best suited for oily and combination skin types with moderate-to-severe hormonal acne (IGA score 3–4). It is particularly effective for patients experiencing androgen-driven breakouts — characterized by deep, inflamed pimples concentrated along the jawline, chin, and lower cheeks, often worsening with hormonal fluctuations (menstrual cycle, puberty, stress). The cream base makes it more tolerable than retinoids for dry skin types, but the propylene glycol content (~25%) can cause minor stinging on sensitive or barrier-compromised skin. It is not ideal for fungal acne, regardless of skin type. Best results are seen in patients with moderate-to-severe inflammatory or mixed (inflammatory + comedonal) facial acne with a hormonal component.\"\n          }\n        },\n        {\n          \"@type\": \"Question\",\n          \"name\": \"How long until I see results from Clascoterone Cream (Winlevi)?\",\n          \"acceptedAnswer\": {\n            \"@type\": \"Answer\",\n            \"text\": \"Initial improvements may be noticed around 4 weeks of consistent twice-daily use. However, the pivotal Phase 3 clinical trials assessed outcomes at 12 weeks — and this is the timeframe used to evaluate meaningful clinical efficacy. Statistically significant reductions in both inflammatory lesion counts (~19 lesions from baseline) and non-inflammatory lesions were demonstrated at week 12. Treatment success (IGA 0 or 1, i.e., clear or almost clear) was achieved in 18–20% of patients versus 6–9% in the vehicle group. It is important to maintain a consistent twice-daily routine for a full 12 weeks before evaluating whether the treatment is working for you. Do not discontinue prematurely — like most prescription acne treatments, early patience is required.\"\n          }\n        },\n        {\n          \"@type\": \"Question\",\n          \"name\": \"Where does Winlevi go in my skincare routine?\",\n          \"acceptedAnswer\": {\n            \"@type\": \"Answer\",\n            \"text\": \"Winlevi is applied after cleansing and before moisturizer, twice daily — morning and evening. The correct routine order is: (1) Gentle Cleanser → (2) Optional Toner → (3) Winlevi Cream (applied to clean, dry skin, ~1g \/ 2 fingertip units) → (4) Moisturizer → (5) Sunscreen (AM only). Wait 1–2 minutes after applying Winlevi before layering moisturizer. Avoid using harsh, drying, or alcohol-heavy products immediately after application. Unlike retinoids, Winlevi can be used in the morning without photosensitivity concerns, making the twice-daily protocol more flexible.\"\n          }\n        },\n        {\n          \"@type\": \"Question\",\n          \"name\": \"Is Clascoterone Cream (Winlevi) comedogenic? Will it clog pores?\",\n          \"acceptedAnswer\": {\n            \"@type\": \"Answer\",\n            \"text\": \"Winlevi has a comedogenic rating of approximately 2\/5 — considered low. The key potentially comedogenic ingredients are cetyl alcohol (rated 2\/5) and mineral oil (rated 0–1\/5 for cosmetic-grade formulations). In practice, because Winlevi directly reduces androgen-driven sebum production, it generally helps to reduce the conditions that lead to comedones rather than worsen them. Some user reviews do mention clogged pores or new comedones during early use — this may reflect the initial adjustment period or the cream base interacting with individual skin chemistry. For users with highly comedone-prone skin, discuss with your dermatologist and monitor response during the first 4 weeks. The formula does not contain any heavy waxes, butters, or high-rated comedogenic oils.\"\n          }\n        },\n        {\n          \"@type\": \"Question\",\n          \"name\": \"How long does Winlevi Cream last after opening?\",\n          \"acceptedAnswer\": {\n            \"@type\": \"Answer\",\n            \"text\": \"Winlevi Cream should be used within 12 months of opening. At twice-daily whole-face application (~1g per application), a 30g tube lasts approximately 2 weeks and a 60g tube approximately 4 weeks with consistent use. Store at room temperature (68–77°F \/ 20–25°C), away from heat and direct sunlight. Always check the expiry date on the tube. Do not use after the printed expiration date regardless of whether the tube has been opened. Keep the cap tightly closed after each use to prevent contamination and oxidative degradation of the formula.\"\n          }\n        }\n      ]\n    },\n    {\n      \"@type\": \"HowTo\",\n      \"name\": \"How to use Winlevi Clascoterone Cream 1%\",\n      \"totalTime\": \"PT2M\",\n      \"step\": [\n        {\n          \"@type\": \"HowToStep\",\n          \"position\": 1,\n          \"name\": \"Cleanse \u0026amp; Dry Thoroughly\",\n          \"text\": \"Wash your face with a gentle, non-medicated cleanser and pat dry completely. Winlevi should be applied to clean, dry skin only — avoid applying to damp or wet skin, which can cause unnecessary irritation.\"\n        },\n        {\n          \"@type\": \"HowToStep\",\n          \"position\": 2,\n          \"name\": \"Dispense the Right Amount\",\n          \"text\": \"Use approximately 1 gram — roughly equivalent to two fingertip units — per application. Do not over-apply; using excessive amounts does not improve efficacy and may increase the risk of local skin reactions.\"\n        },\n        {\n          \"@type\": \"HowToStep\",\n          \"position\": 3,\n          \"name\": \"Apply to the Full Affected Area\",\n          \"text\": \"Spread a thin, uniform layer across the entire acne-prone area (full face or affected zones). Do not spot-treat individual pimples — whole-area application is essential for optimal results per the clinical protocol.\"\n        },\n        {\n          \"@type\": \"HowToStep\",\n          \"position\": 4,\n          \"name\": \"Wait, Then Layer\",\n          \"text\": \"Allow 1–2 minutes for the cream to absorb before applying moisturizer or sunscreen. Avoid using harsh, abrasive, or alcohol-heavy toners or astringents immediately after application as these can intensify irritation.\"\n        },\n        {\n          \"@type\": \"HowToStep\",\n          \"position\": 5,\n          \"name\": \"Use Twice Daily — Consistently\",\n          \"text\": \"Apply every morning and every evening. Consistency is critical: clinical trials were conducted at twice-daily application for 12 continuous weeks. If you miss a dose, apply at the next scheduled time — never double up.\"\n        },\n        {\n          \"@type\": \"HowToStep\",\n          \"position\": 6,\n          \"name\": \"Wash Hands Before \u0026amp; After\",\n          \"text\": \"Always wash your hands before applying to avoid transferring bacteria, and again afterward to prevent accidental contact with eyes, mouth, or mucous membranes. If accidental contact occurs, rinse thoroughly with water.\"\n        }\n      ]\n    },\n    {\n      \"@type\": \"ItemList\",\n      \"name\": \"Winlevi Clascoterone Cream 1% — Ingredients (INCI)\",\n      \"numberOfItems\": 9,\n      \"itemListElement\": [\n        {\n          \"@type\": \"ListItem\",\n          \"position\": 1,\n          \"name\": \"Active: Clascoterone 10 mg\/g (1%)Inactive: Cetyl Alcohol\"\n        },\n        {\n          \"@type\": \"ListItem\",\n          \"position\": 2,\n          \"name\": \"Citric Acid Monohydrate\"\n        },\n        {\n          \"@type\": \"ListItem\",\n          \"position\": 3,\n          \"name\": \"Edetate Disodium\"\n        },\n        {\n          \"@type\": \"ListItem\",\n          \"position\": 4,\n          \"name\": \"Mineral Oil (Paraffinum Liquidum)\"\n        },\n        {\n          \"@type\": \"ListItem\",\n          \"position\": 5,\n          \"name\": \"Mono and Diglycerides\"\n        },\n        {\n          \"@type\": \"ListItem\",\n          \"position\": 6,\n          \"name\": \"Polysorbate 80\"\n        },\n        {\n          \"@type\": \"ListItem\",\n          \"position\": 7,\n          \"name\": \"Propylene Glycol\"\n        },\n        {\n          \"@type\": \"ListItem\",\n          \"position\": 8,\n          \"name\": \"Purified Water\"\n        },\n        {\n          \"@type\": \"ListItem\",\n          \"position\": 9,\n          \"name\": \"Tocopherol (Vitamin E)\"\n        }\n      ]\n    }\n  ]\n}\u003c\/script\u003e\n\n  \u003csvg width=\"0\" height=\"0\" style=\"position:absolute\" aria-hidden=\"true\" focusable=\"false\"\u003e\n    \u003cdefs\u003e\n      \u003csymbol id=\"i-check\" viewbox=\"0 0 24 24\"\u003e\u003cpolyline points=\"20 6 9 17 4 12\"\u003e\u003c\/polyline\u003e\u003c\/symbol\u003e\n      \u003csymbol id=\"i-x\" viewbox=\"0 0 24 24\"\u003e\u003cline x1=\"18\" y1=\"6\" x2=\"6\" y2=\"18\"\u003e\u003c\/line\u003e\u003cline x1=\"6\" y1=\"6\" x2=\"18\" 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24\"\u003e\u003cpath d=\"M20 8l-8-4-8 4v8l8 4 8-4V8z\"\u003e\u003c\/path\u003e\u003cline x1=\"4\" y1=\"8\" x2=\"20\" y2=\"8\"\u003e\u003c\/line\u003e\u003cline x1=\"12\" y1=\"12\" x2=\"12\" y2=\"20\"\u003e\u003c\/line\u003e\u003c\/symbol\u003e\n      \u003csymbol id=\"i-calendar\" viewbox=\"0 0 24 24\"\u003e\u003crect x=\"3\" y=\"5\" width=\"18\" height=\"16\" rx=\"2\"\u003e\u003c\/rect\u003e\u003cline x1=\"3\" y1=\"10\" x2=\"21\" y2=\"10\"\u003e\u003c\/line\u003e\u003cline x1=\"8\" y1=\"3\" x2=\"8\" y2=\"7\"\u003e\u003c\/line\u003e\u003cline x1=\"16\" y1=\"3\" x2=\"16\" y2=\"7\"\u003e\u003c\/line\u003e\u003c\/symbol\u003e\n      \u003csymbol id=\"i-home\" viewbox=\"0 0 24 24\"\u003e\u003cpath d=\"M3 11l9-7 9 7v9a2 2 0 01-2 2h-4v-7H9v7H5a2 2 0 01-2-2v-9z\"\u003e\u003c\/path\u003e\u003c\/symbol\u003e\n      \u003csymbol id=\"i-plane\" viewbox=\"0 0 24 24\"\u003e\u003cpath d=\"M22 12l-9 4-3 6-2-5-5-2 6-3 4-9 9 9z\"\u003e\u003c\/path\u003e\u003c\/symbol\u003e\n      \u003csymbol id=\"i-arrow-right\" viewbox=\"0 0 24 24\"\u003e\u003cline x1=\"5\" y1=\"12\" x2=\"19\" y2=\"12\"\u003e\u003c\/line\u003e\u003cpolyline points=\"12 5 19 12 12 19\"\u003e\u003c\/polyline\u003e\u003c\/symbol\u003e\n    \u003c\/defs\u003e\n  \u003c\/svg\u003e\n\n  \n  \u003csection id=\"pp-overview\" class=\"pp-hero\" aria-labelledby=\"pp-hero-title\"\u003e\n    \u003ch2 id=\"pp-hero-title\" class=\"pp-sr-only\" style=\"position:absolute;left:-10000px\"\u003eProduct overview\u003c\/h2\u003e\n    \u003cdiv class=\"pp-origin\"\u003e\n      \u003csvg class=\"pin\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-pin\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\n      \u003cspan class=\"text\"\u003eMade in Various\u003c\/span\u003e\n      \u003cspan class=\"dot\"\u003e\u003c\/span\u003e\n      \u003cspan class=\"tag\"\u003eINTERNATIONAL\u003c\/span\u003e\n    \u003c\/div\u003e\n    \u003cp class=\"pp-subtitle\"\u003eThe world's first and only FDA-approved prescription topical antiandrogen for acne. Clascoterone 1% acts directly at androgen receptors in the skin — blocking DHT-driven sebum overproduction and inflammatory pathways at the source, without the systemic hormonal effects of oral spironolactone. A true breakthrough for hormonal acne in patients 12 years and older.\u003c\/p\u003e\n    \u003cdiv class=\"pp-badges\"\u003e\n\u003cspan class=\"pp-badge\"\u003e\u003csvg class=\"check\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e FDA-Approved 2020\u003c\/span\u003e\u003cspan class=\"pp-badge\"\u003e\u003csvg class=\"check\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e First-in-Class Topical Antiandrogen\u003c\/span\u003e\u003cspan class=\"pp-badge\"\u003e\u003csvg class=\"check\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Fragrance-Free\u003c\/span\u003e\u003cspan class=\"pp-badge\"\u003e\u003csvg class=\"check\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Paraben-Free\u003c\/span\u003e\u003cspan class=\"pp-badge\"\u003e\u003csvg class=\"check\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Works for Male \u0026amp;amp; Female Acne\u003c\/span\u003e\u003cspan class=\"pp-badge\"\u003e\u003csvg class=\"check\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Non-Antibiotic Formula\u003c\/span\u003e\u003cspan class=\"pp-badge\"\u003e\u003csvg class=\"check\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Prescription Only (Rx)\u003c\/span\u003e\n\u003c\/div\u003e\n    \u003cnav class=\"pp-nav\" aria-label=\"Jump to product section\"\u003e\n      \u003cdiv class=\"pp-nav-head\"\u003eJump to section\u003c\/div\u003e\n      \u003cdiv class=\"pp-nav-list\"\u003e\n        \u003ca href=\"#pp-safety\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-shield-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003cspan class=\"lbl\"\u003eSafety\u003c\/span\u003e\u003csvg class=\"ico arrow\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-arrow-right\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/a\u003e\n        \u003ca href=\"#pp-ingredients\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-flask\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003cspan class=\"lbl\"\u003eIngredients\u003c\/span\u003e\u003csvg class=\"ico arrow\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-arrow-right\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/a\u003e\n        \u003ca href=\"#pp-routine\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-refresh\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003cspan class=\"lbl\"\u003eRoutine\u003c\/span\u003e\u003csvg class=\"ico arrow\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-arrow-right\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/a\u003e\n        \u003ca href=\"#pp-how-to-use\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-list\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003cspan class=\"lbl\"\u003eHow to use\u003c\/span\u003e\u003csvg class=\"ico arrow\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-arrow-right\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/a\u003e\n        \u003ca href=\"#pp-skin-types\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-target\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003cspan class=\"lbl\"\u003eSkin types\u003c\/span\u003e\u003csvg class=\"ico arrow\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-arrow-right\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/a\u003e\n        \u003ca href=\"#pp-results\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-trending\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003cspan class=\"lbl\"\u003eResults\u003c\/span\u003e\u003csvg class=\"ico arrow\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-arrow-right\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/a\u003e\n        \u003ca href=\"#pp-reviews\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-star\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003cspan class=\"lbl\"\u003eReviews\u003c\/span\u003e\u003csvg class=\"ico arrow\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-arrow-right\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/a\u003e\n        \u003ca href=\"#pp-dupes\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-coin\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003cspan class=\"lbl\"\u003eDupes\u003c\/span\u003e\u003csvg class=\"ico arrow\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-arrow-right\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/a\u003e\n        \u003ca href=\"#pp-faq\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-help\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003cspan class=\"lbl\"\u003eFAQ\u003c\/span\u003e\u003csvg class=\"ico arrow\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-arrow-right\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/a\u003e\n      \u003c\/div\u003e\n    \u003c\/nav\u003e\n    \n    \u003cdiv class=\"pp-scorecard\"\u003e\n      \u003cdiv class=\"item\"\u003e\n\u003cdiv class=\"lbl\"\u003ePregnancy\u003c\/div\u003e\n\u003cdiv class=\"val caution\"\u003e\n\u003csvg class=\"alert\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-info\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Caution\u003c\/div\u003e\n\u003c\/div\u003e\n      \u003cdiv class=\"item\"\u003e\n\u003cdiv class=\"lbl\"\u003eFungal Acne\u003c\/div\u003e\n\u003cdiv class=\"val warning\"\u003e\n\u003csvg class=\"x\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-x\"\u003e\u003c\/use\u003e\u003c\/svg\u003e No\u003c\/div\u003e\n\u003c\/div\u003e\n      \u003cdiv class=\"item\"\u003e\n\u003cdiv class=\"lbl\"\u003eComedogenic\u003c\/div\u003e\n\u003cdiv class=\"val caution\"\u003e2\/5\u003c\/div\u003e\n\u003c\/div\u003e\n    \u003c\/div\u003e\n    \u003cdiv class=\"pp-specs\"\u003e\n\u003cdiv class=\"pp-spec\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-sparkle\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv class=\"lbl\"\u003eActive\u003c\/div\u003e\n\u003cdiv class=\"val\"\u003eClascoterone 1%\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-spec\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-bottle\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv class=\"lbl\"\u003eSize\u003c\/div\u003e\n\u003cdiv class=\"val\"\u003e30g \/ 60g Tube\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-spec\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-droplet\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv class=\"lbl\"\u003eType\u003c\/div\u003e\n\u003cdiv class=\"val\"\u003eCream (Rx)\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-spec\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-list\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv class=\"lbl\"\u003eIngredients\u003c\/div\u003e\n\u003cdiv class=\"val\"\u003e11 Total\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-spec\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-calendar\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv class=\"lbl\"\u003ePAO\u003c\/div\u003e\n\u003cdiv class=\"val\"\u003e12 Months\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n    \n    \u003cdiv class=\"pp-videos\"\u003e\n      \u003cspan class=\"eyebrow\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-star\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Real reviews · YouTube Shorts\u003c\/span\u003e\n      \u003cdiv class=\"pp-videos-grid\"\u003e\n        \u003cdiv class=\"pp-videos-frame\"\u003e\n          \u003ciframe src=\"https:\/\/www.youtube.com\/embed\/hVhqMoKAS00?modestbranding=1\u0026amp;rel=0\u0026amp;playsinline=1\" title=\"YouTube Shorts review 1 — Winlevi Clascoterone Cream 1%\" loading=\"lazy\" allow=\"accelerometer; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share; fullscreen\" allowfullscreen referrerpolicy=\"strict-origin-when-cross-origin\"\u003e\u003c\/iframe\u003e\n        \u003c\/div\u003e\n\u003cdiv class=\"pp-videos-frame\"\u003e\n          \u003ciframe src=\"https:\/\/www.youtube.com\/embed\/igcivZqjDiI?modestbranding=1\u0026amp;rel=0\u0026amp;playsinline=1\" title=\"YouTube Shorts review 2 — Winlevi Clascoterone Cream 1%\" loading=\"lazy\" allow=\"accelerometer; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share; fullscreen\" allowfullscreen referrerpolicy=\"strict-origin-when-cross-origin\"\u003e\u003c\/iframe\u003e\n        \u003c\/div\u003e\n\u003cdiv class=\"pp-videos-frame\"\u003e\n          \u003ciframe src=\"https:\/\/www.youtube.com\/embed\/WaSKMr5LOM0?modestbranding=1\u0026amp;rel=0\u0026amp;playsinline=1\" title=\"YouTube Shorts review 3 — Winlevi Clascoterone Cream 1%\" loading=\"lazy\" allow=\"accelerometer; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share; fullscreen\" allowfullscreen referrerpolicy=\"strict-origin-when-cross-origin\"\u003e\u003c\/iframe\u003e\n        \u003c\/div\u003e\n      \u003c\/div\u003e\n    \u003c\/div\u003e\n    \n    \u003cdiv class=\"pp-highlight\"\u003e\n      \u003cspan class=\"eyebrow\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-sparkle\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Why it's different\u003c\/span\u003e\n      \u003ch3\u003eFirst-in-Class Mechanism\u003c\/h3\u003e\n      \u003cp\u003eClascoterone is the only topical androgen receptor inhibitor approved for acne. It competes with DHT at the androgen receptor in the sebaceous gland, reducing sebum overproduction at the molecular level.\u003c\/p\u003e\n    \u003c\/div\u003e\n  \u003c\/section\u003e\n\n\n  \u003cmotion-element data-motion=\"fade-up\" data-motion-delay=\"50\"\u003e\u003cdiv class=\"pp-title\" id=\"pp-sensory\"\u003e\n\u003cspan class=\"eyebrow\"\u003e01\u003c\/span\u003e\u003ch2\u003eTexture \u0026amp; feel\u003c\/h2\u003e\n\u003cspan class=\"num\"\u003eSENSORY\u003c\/span\u003e\n\u003c\/div\u003e\u003c\/motion-element\u003e\n\n\u003cdiv class=\"pp-sensory\"\u003e\n\u003cdiv class=\"pp-sensory-item\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-droplet\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv class=\"label\"\u003eConsistency\u003c\/div\u003e\n\u003cdiv class=\"value\"\u003eSoft Cream\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-sensory-item\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-wind\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv class=\"label\"\u003eScent\u003c\/div\u003e\n\u003cdiv class=\"value\"\u003eFragrance-Free\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-sensory-item\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-clock\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv class=\"label\"\u003eAbsorption\u003c\/div\u003e\n\u003cdiv class=\"value\"\u003e1–2 Minutes\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-sensory-item\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-target\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv class=\"label\"\u003eFinish\u003c\/div\u003e\n\u003cdiv class=\"value\"\u003eSoft Matte\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"pp-features\"\u003e\n\u003cdiv class=\"pp-feature\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-flask\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003ch4\u003eFirst-in-Class Mechanism\u003c\/h4\u003e\n\u003cp\u003eClascoterone is the only topical androgen receptor inhibitor approved for acne. It competes with DHT at the androgen receptor in the sebaceous gland, reducing sebum overproduction at the molecular level.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-feature\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-target\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003ch4\u003eTargets Hormonal Acne Root Cause\u003c\/h4\u003e\n\u003cp\u003eUnlike retinoids or antibiotics, Winlevi directly addresses the androgen-driven pathway — the root cause of hormonal acne in both males and females, including jawline, chin, and cheek breakouts.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-feature\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-shield-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003ch4\u003eLocally Active, Systemically Safe\u003c\/h4\u003e\n\u003cp\u003eClascoterone is rapidly metabolized in the skin to an inactive cortexolone form, minimizing systemic absorption. Unlike oral spironolactone, it does not cause blood pressure changes or gynecomastia in males.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-feature\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-sparkle\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003ch4\u003eApproved for Male \u0026amp; Female Patients\u003c\/h4\u003e\n\u003cp\u003eUnlike oral antiandrogens (e.g., spironolactone) which cannot be used in males due to feminizing effects, Winlevi is approved for both male and female patients 12 years of age and older.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-feature\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-droplet\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003ch4\u003eNon-Drying Formula\u003c\/h4\u003e\n\u003cp\u003eUnlike retinoids or benzoyl peroxide, Winlevi's cream base with cetyl alcohol and vitamin E is moisturizing by design — reducing acne without stripping the skin barrier.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-feature\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-refresh\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003ch4\u003eCombats Antibiotic Resistance\u003c\/h4\u003e\n\u003cp\u003eAs a non-antibiotic treatment, Winlevi poses no risk of contributing to antibiotic resistance — an increasingly important consideration in long-term acne management.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cmotion-element data-motion=\"fade-up\" data-motion-delay=\"100\"\u003e\u003cdiv class=\"pp-title\" id=\"pp-safety\"\u003e\n\u003cspan class=\"eyebrow\"\u003e02\u003c\/span\u003e\u003ch2\u003eSafety \u0026amp; compatibility\u003c\/h2\u003e\n\u003cspan class=\"num\"\u003eSAFE\u003c\/span\u003e\n\u003c\/div\u003e\u003c\/motion-element\u003e\n\n\u003cdiv class=\"pp-safety\"\u003e\n\u003cdiv class=\"pp-safety-item caution\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-info\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cstrong\u003ePregnancy Safety\u003c\/strong\u003e\n\u003cp\u003eNot established in humans. Animal studies at doses 8–39× the human dose showed fetal malformations. Use only if the potential benefit justifies the potential risk. Consult your healthcare provider.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-safety-item caution\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-info\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cstrong\u003eBreastfeeding Safety\u003c\/strong\u003e\n\u003cp\u003eIt is unknown whether clascoterone passes into breast milk. Consult your doctor before using while breastfeeding. The prescribing label advises discussing feeding options with your healthcare provider.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-safety-item warning\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-flask\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cstrong\u003eFungal Acne (Malassezia) Safety\u003c\/strong\u003e\n\u003cp\u003eNOT safe for fungal acne. The formula contains Polysorbate 80 (a polysorbate ester) and Mono \u0026amp; Diglycerides — both fatty acid esters known to feed Malassezia furfur. Avoid if you suspect pityrosporum folliculitis.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-safety-item safe\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cstrong\u003eSuitable for Males\u003c\/strong\u003e\n\u003cp\u003eUnlike oral antiandrogens, Winlevi is the only topical antiandrogen approved for use in both males and females without risk of systemic feminizing side effects such as gynecomastia.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-safety-item caution\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-info\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cstrong\u003eHPA Axis Suppression\u003c\/strong\u003e\n\u003cp\u003eHypothalamic-pituitary-adrenal (HPA) axis suppression can occur, especially with extensive use or in adolescents. All Phase 2 subjects normalized within 4 weeks of stopping treatment. Monitor with prolonged use.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-safety-item caution\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-info\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cstrong\u003eHyperkalemia Risk\u003c\/strong\u003e\n\u003cp\u003eElevated potassium was observed in a small subset of patients in clinical trials. The risk is most significant in children under 12, which is one reason the product is not approved for that age group.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-safety-item safe\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cstrong\u003eNo Retinoids, No Antibiotics\u003c\/strong\u003e\n\u003cp\u003eWinlevi contains no retinoids, benzoyl peroxide, salicylic acid, or antibiotics. This makes it complementary to many existing acne treatments and suitable as part of a multi-modal regimen.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-safety-item info\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cstrong\u003eAvoid on Compromised Skin\u003c\/strong\u003e\n\u003cp\u003eDo not apply to eczematous, cut, abraded, or sunburned skin. Avoid contact with eyes, mouth, and mucous membranes. Wash hands before and after application.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cmotion-element data-motion=\"fade-up\" data-motion-delay=\"150\"\u003e\u003cdiv class=\"pp-title\" id=\"pp-ingredients\"\u003e\n\u003cspan class=\"eyebrow\"\u003e03\u003c\/span\u003e\u003ch2\u003eIngredient breakdown\u003c\/h2\u003e\n\u003cspan class=\"num\"\u003eINGREDIENTS\u003c\/span\u003e\n\u003c\/div\u003e\u003c\/motion-element\u003e\n\n\u003cdiv class=\"pp-ingredient\" itemscope itemtype=\"https:\/\/schema.org\/ChemicalSubstance\"\u003e\n\u003cdiv class=\"ing-head\"\u003e\n\u003cdiv class=\"ing-icon\" aria-hidden=\"true\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-star\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003ch3 itemprop=\"name\"\u003eClascoterone (Cortexolone 17α-Propionate) 1%\u003cspan class=\"tag proven\"\u003eProven\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cp class=\"ing-desc\" itemprop=\"description\"\u003eThe world's first topical androgen receptor inhibitor approved for acne. Clascoterone is a steroid derivative structurally similar to spironolactone and dihydrotestosterone (DHT). It competitively blocks the androgen receptor in sebaceous glands and hair follicles, reducing DHT-stimulated sebum production and downstream inflammatory cytokine synthesis — without entering systemic circulation in meaningful quantities.\u003c\/p\u003e\n\u003cul class=\"pp-science\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eFDA Approval:\u003c\/strong\u003e Approved August 2020 (NDA 213433) for acne vulgaris, ages 12+\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePhase 3 Trials:\u003c\/strong\u003e Two pivotal RCTs (N=1,440) demonstrated statistically significant reductions in both inflammatory and non-inflammatory lesion counts vs. vehicle at 12 weeks\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIGA Success Rate:\u003c\/strong\u003e 18.4%–20.3% treatment success vs. 6.5%–9.0% vehicle (p\u0026lt;0.001)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLesion Reduction:\u003c\/strong\u003e Mean reduction of ~19 inflammatory lesions from baseline at week 12\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMechanism:\u003c\/strong\u003e Competes with DHT for androgen receptor binding; rapidly metabolized locally to inactive cortexolone — limiting systemic effects\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eComparable to Tretinoin:\u003c\/strong\u003e A Phase 2 active-controlled trial found clascoterone similar in efficacy to topical tretinoin for mild-to-moderate acne\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cdiv class=\"pp-warning caution\"\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\" style=\"display:inline-block;width:14px;height:14px;vertical-align:middle\"\u003e\u003cuse href=\"#i-info\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\n\u003cdiv\u003eThis is a prescription-regulated active ingredient — not a cosmetic. Speak with a licensed healthcare provider before use. Not for spot treatment; apply to the entire affected area for optimal efficacy.\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"pp-ingredient\" itemscope itemtype=\"https:\/\/schema.org\/ChemicalSubstance\"\u003e\n\u003cdiv class=\"ing-head\"\u003e\n\u003cdiv class=\"ing-icon\" aria-hidden=\"true\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-bottle\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003ch3 itemprop=\"name\"\u003eCetyl Alcohol ~2.5%\u003cspan class=\"tag supporting\"\u003eEmollient\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cp class=\"ing-desc\" itemprop=\"description\"\u003eA fatty alcohol (not a drying alcohol) that functions as an emollient and emulsion stabilizer. Cetyl alcohol gives the cream its soft, spreadable consistency and helps the active ingredient distribute evenly across the skin surface. Despite the \"alcohol\" in its name, it is non-irritating and non-drying — completely different from ethanol or denatured alcohol.\u003c\/p\u003e\n\u003cul class=\"pp-science\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eComedogenicity:\u003c\/strong\u003e Rated 2\/5 — low to moderate; generally well tolerated\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFunction:\u003c\/strong\u003e Emollient, thickener, emulsion stabilizer — improves skin feel\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFatty Acid Note:\u003c\/strong\u003e Contains C16 fatty acid chain; may technically feed Malassezia — relevant for fungal acne sufferers\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"pp-ingredient\" itemscope itemtype=\"https:\/\/schema.org\/ChemicalSubstance\"\u003e\n\u003cdiv class=\"ing-head\"\u003e\n\u003cdiv class=\"ing-icon\" aria-hidden=\"true\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-shield-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003ch3 itemprop=\"name\"\u003eTocopherol (Vitamin E) trace\u003cspan class=\"tag supporting\"\u003eAntioxidant\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cp class=\"ing-desc\" itemprop=\"description\"\u003eA potent lipid-soluble antioxidant that protects the formula's oils from oxidative degradation. Tocopherol also provides mild skin-conditioning benefits, helping to maintain the skin barrier and neutralize free radicals at the skin surface. It contributes to the overall tolerability of the cream.\u003c\/p\u003e\n\u003cul class=\"pp-science\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Naturally derived (d-alpha-tocopherol) or synthetic form\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBenefit:\u003c\/strong\u003e Stabilizes mineral oil component; mild anti-inflammatory skin conditioning\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSafety:\u003c\/strong\u003e Well tolerated; rare contact allergy possible in sensitive individuals\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cdiv class=\"pp-callout positive\"\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\" style=\"display:inline-block;width:14px;height:14px;vertical-align:middle\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\n\u003cdiv\u003eVitamin E contributes to the non-drying character of this cream — making it more comfortable than many other topical acne treatments such as retinoids or benzoyl peroxide.\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"pp-ingredient\" itemscope itemtype=\"https:\/\/schema.org\/ChemicalSubstance\"\u003e\n\u003cdiv class=\"ing-head\"\u003e\n\u003cdiv class=\"ing-icon\" aria-hidden=\"true\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-droplet\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003ch3 itemprop=\"name\"\u003ePropylene Glycol ~25%\u003cspan class=\"tag supporting\"\u003eHumectant\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cp class=\"ing-desc\" itemprop=\"description\"\u003eA humectant and solvent that draws moisture into the skin and helps dissolve the active ingredient for even distribution. Propylene glycol also acts as a penetration enhancer, improving the delivery of clascoterone into the sebaceous follicle. Present in a relatively high proportion (250 mg per gram).\u003c\/p\u003e\n\u003cul class=\"pp-science\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eFunction:\u003c\/strong\u003e Humectant, solvent, penetration enhancer, preservation booster\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 250 mg\/g (per SmPC listing) — a notably active level\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNote:\u003c\/strong\u003e May cause mild stinging in some users with compromised barrier; patch test advised for sensitive skin\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"pp-ingredient\" itemscope itemtype=\"https:\/\/schema.org\/ChemicalSubstance\"\u003e\n\u003cdiv class=\"ing-head\"\u003e\n\u003cdiv class=\"ing-icon\" aria-hidden=\"true\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-flask\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003ch3 itemprop=\"name\"\u003eMineral Oil (Paraffinum Liquidum) variable\u003cspan class=\"tag supporting\"\u003eOcclusive\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cp class=\"ing-desc\" itemprop=\"description\"\u003eA well-refined occlusive emollient that forms a light barrier on the skin surface to reduce transepidermal water loss. Despite its reputation among natural beauty advocates, cosmetic-grade mineral oil is inert, non-sensitizing, and has a very low comedogenic rating. It contributes to the moisturizing, non-drying profile of the formula.\u003c\/p\u003e\n\u003cul class=\"pp-science\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eComedogenicity:\u003c\/strong\u003e 0–1\/5 — cosmetic-grade mineral oil is generally non-comedogenic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSafety:\u003c\/strong\u003e Extensively studied; no evidence of systemic toxicity from topical application\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFunction:\u003c\/strong\u003e Softens skin, reduces water loss, improves spreadability\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"pp-ingredient\" itemscope itemtype=\"https:\/\/schema.org\/ChemicalSubstance\"\u003e\n\u003cdiv class=\"ing-head\"\u003e\n\u003cdiv class=\"ing-icon\" aria-hidden=\"true\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-flask\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003ch3 itemprop=\"name\"\u003ePolysorbate 80 + Mono \u0026amp;amp; Diglycerides low\u003cspan class=\"tag supporting\"\u003eEmulsifier\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cp class=\"ing-desc\" itemprop=\"description\"\u003eTwo emulsifying agents that keep the oil and water phases of the cream uniformly blended. Polysorbate 80 is a polyoxyethylene sorbitan ester with moderate emulsifying power. Mono and Diglycerides are partial glycerides that stabilize the formula. Both are effective and widely used — but both are esters that can serve as a food source for Malassezia yeasts, making this product unsuitable for fungal acne-prone individuals.\u003c\/p\u003e\n\u003cul class=\"pp-science\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eFungal Acne Flag:\u003c\/strong\u003e Polysorbate 80 and glyceride esters are known Malassezia-feeding ingredients\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eComedogenicity:\u003c\/strong\u003e Polysorbate 80 rated 1–2\/5; generally considered low risk for comedones\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFunction:\u003c\/strong\u003e Essential for cream stability and active ingredient distribution\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cdiv class=\"pp-warning caution\"\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\" style=\"display:inline-block;width:14px;height:14px;vertical-align:middle\"\u003e\u003cuse href=\"#i-info\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\n\u003cdiv\u003eIf you suffer from pityrosporum folliculitis (fungal acne), this formula is NOT recommended. Consult a dermatologist for an alternative treatment approach.\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"pp-accordion\"\u003e\n\u003cinput type=\"checkbox\" id=\"pp-inci\"\u003e\n\u003clabel for=\"pp-inci\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\" style=\"display:inline-block;width:14px;height:14px;vertical-align:middle\"\u003e\u003cuse href=\"#i-list\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Full Ingredients (INCI)\u003c\/label\u003e\n\u003cdiv class=\"pp-acc-content\"\u003e\n\u003cp\u003e\u003cstrong\u003e11 ingredients\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"font-size:0.85em;color:var(--pp-text-muted);line-height:1.8\"\u003e\u003cstrong\u003eActive:\u003c\/strong\u003e Clascoterone 10 mg\/g (1%)\u003cbr\u003e\u003cstrong\u003eInactive:\u003c\/strong\u003e Cetyl Alcohol, Citric Acid Monohydrate, Edetate Disodium, Mineral Oil (Paraffinum Liquidum), Mono and Diglycerides, Polysorbate 80, Propylene Glycol, Purified Water, Tocopherol (Vitamin E)\u003c\/p\u003e\n\u003cdiv class=\"free-list\"\u003e\n\u003cstrong\u003eFREE FROM:\u003c\/strong\u003e Fragrances, Parabens, Retinoids, Antibiotics, Benzoyl Peroxide, Salicylic Acid, Sulfates (SLS\/SLES), Silicones, Lanolin, Gluten, Soy, Dyes, Denatured Alcohol (Ethanol)\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cmotion-element data-motion=\"fade-up\" data-motion-delay=\"200\"\u003e\u003cdiv class=\"pp-title\" id=\"pp-routine\"\u003e\n\u003cspan class=\"eyebrow\"\u003e04\u003c\/span\u003e\u003ch2\u003eWhere it fits in your routine\u003c\/h2\u003e\n\u003cspan class=\"num\"\u003eROUTINE\u003c\/span\u003e\n\u003c\/div\u003e\u003c\/motion-element\u003e\n\n\u003cdiv class=\"pp-routine\"\u003e\n\u003cdiv class=\"pp-routine-step\"\u003e\n\u003cdiv class=\"num\"\u003e1\u003c\/div\u003e\n\u003cdiv class=\"name\"\u003eGentle Cleanser\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-routine-step\"\u003e\n\u003cdiv class=\"num\"\u003e2\u003c\/div\u003e\n\u003cdiv class=\"name\"\u003eToner (Optional)\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-routine-step current\"\u003e\n\u003cdiv class=\"num\"\u003e3\u003c\/div\u003e\n\u003cdiv class=\"name\"\u003eWinlevi Cream\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-routine-step\"\u003e\n\u003cdiv class=\"num\"\u003e4\u003c\/div\u003e\n\u003cdiv class=\"name\"\u003eMoisturizer\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-routine-step\"\u003e\n\u003cdiv class=\"num\"\u003e5\u003c\/div\u003e\n\u003cdiv class=\"name\"\u003eSunscreen (AM)\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cp style=\"text-align:center;color:var(--pp-text-muted);font-size:0.82em;margin-top:12px\"\u003eApply after cleansing to clean, dry skin — both morning and evening. Allow 1–2 minutes to absorb before layering moisturizer. Do not spot-treat; apply a thin layer (~1g \/ 2 fingertip units) to the entire affected area for best results.\u003c\/p\u003e\n\n\u003cmotion-element data-motion=\"fade-up\" data-motion-delay=\"0\"\u003e\u003cdiv class=\"pp-title\" id=\"pp-how-to-use\"\u003e\n\u003cspan class=\"eyebrow\"\u003e05\u003c\/span\u003e\u003ch2\u003eHow to use\u003c\/h2\u003e\n\u003cspan class=\"num\"\u003eHOW TO USE\u003c\/span\u003e\n\u003c\/div\u003e\u003c\/motion-element\u003e\n\n\u003cdiv class=\"pp-steps\"\u003e\n\u003cdiv class=\"pp-step\"\u003e\n\u003cdiv class=\"num\"\u003e1\u003c\/div\u003e\n\u003cdiv\u003e\n\u003ch4\u003eCleanse \u0026amp; Dry Thoroughly\u003c\/h4\u003e\n\u003cp\u003eWash your face with a gentle, non-medicated cleanser and pat dry completely. Winlevi should be applied to clean, dry skin only — avoid applying to damp or wet skin, which can cause unnecessary irritation.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-step\"\u003e\n\u003cdiv class=\"num\"\u003e2\u003c\/div\u003e\n\u003cdiv\u003e\n\u003ch4\u003eDispense the Right Amount\u003c\/h4\u003e\n\u003cp\u003eUse approximately 1 gram — roughly equivalent to two fingertip units — per application. Do not over-apply; using excessive amounts does not improve efficacy and may increase the risk of local skin reactions.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-step\"\u003e\n\u003cdiv class=\"num\"\u003e3\u003c\/div\u003e\n\u003cdiv\u003e\n\u003ch4\u003eApply to the Full Affected Area\u003c\/h4\u003e\n\u003cp\u003eSpread a thin, uniform layer across the entire acne-prone area (full face or affected zones). Do not spot-treat individual pimples — whole-area application is essential for optimal results per the clinical protocol.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-step\"\u003e\n\u003cdiv class=\"num\"\u003e4\u003c\/div\u003e\n\u003cdiv\u003e\n\u003ch4\u003eWait, Then Layer\u003c\/h4\u003e\n\u003cp\u003eAllow 1–2 minutes for the cream to absorb before applying moisturizer or sunscreen. Avoid using harsh, abrasive, or alcohol-heavy toners or astringents immediately after application as these can intensify irritation.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-step\"\u003e\n\u003cdiv class=\"num\"\u003e5\u003c\/div\u003e\n\u003cdiv\u003e\n\u003ch4\u003eUse Twice Daily — Consistently\u003c\/h4\u003e\n\u003cp\u003eApply every morning and every evening. Consistency is critical: clinical trials were conducted at twice-daily application for 12 continuous weeks. If you miss a dose, apply at the next scheduled time — never double up.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-step\"\u003e\n\u003cdiv class=\"num\"\u003e6\u003c\/div\u003e\n\u003cdiv\u003e\n\u003ch4\u003eWash Hands Before \u0026amp; After\u003c\/h4\u003e\n\u003cp\u003eAlways wash your hands before applying to avoid transferring bacteria, and again afterward to prevent accidental contact with eyes, mouth, or mucous membranes. If accidental contact occurs, rinse thoroughly with water.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cmotion-element data-motion=\"fade-up\" data-motion-delay=\"50\"\u003e\u003cdiv class=\"pp-title\" id=\"pp-who-is-it-for\"\u003e\n\u003cspan class=\"eyebrow\"\u003e06\u003c\/span\u003e\u003ch2\u003eWho is it for?\u003c\/h2\u003e\n\u003cspan class=\"num\"\u003eWHO\u003c\/span\u003e\n\u003c\/div\u003e\u003c\/motion-element\u003e\n\n\u003cdiv class=\"pp-fit\"\u003e\n\u003cdiv class=\"pp-fit-box yes\"\u003e\n\u003ch4\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003ePerfect for you if:\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003csvg class=\"ico check\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e You have moderate-to-severe hormonal or inflammatory acne (IGA 3–4)\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico check\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Your breakouts are concentrated along the jawline, chin, or cheeks\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico check\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e You are male and cannot use oral antiandrogens like spironolactone\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico check\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e You want a non-antibiotic, non-retinoid acne treatment option\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico check\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e You've tried antibiotics or retinoids with incomplete results\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico check\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e You are 12 years of age or older with a valid prescription\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico check\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e You want to avoid systemic hormonal side effects\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fit-box no\"\u003e\n\u003ch4\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-x\"\u003e\u003c\/use\u003e\u003c\/svg\u003eConsider alternatives if:\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003csvg class=\"ico x\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-x\"\u003e\u003c\/use\u003e\u003c\/svg\u003e You have fungal acne (pityrosporum folliculitis) — formula is NOT safe\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico x\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-x\"\u003e\u003c\/use\u003e\u003c\/svg\u003e You are pregnant or trying to conceive — safety not established\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico x\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-x\"\u003e\u003c\/use\u003e\u003c\/svg\u003e You are under 12 years old — not approved for this age group\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico x\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-x\"\u003e\u003c\/use\u003e\u003c\/svg\u003e You have eczema, active cuts, abrasions, or sunburned skin\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico x\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-x\"\u003e\u003c\/use\u003e\u003c\/svg\u003e You have mild, non-hormonal acne — other options may be sufficient\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico x\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-x\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Cost is a primary concern — Winlevi can cost ~$580 for a 60g tube without insurance\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico x\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-x\"\u003e\u003c\/use\u003e\u003c\/svg\u003e You cannot commit to twice-daily application for at least 12 weeks\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cmotion-element data-motion=\"fade-up\" data-motion-delay=\"100\"\u003e\u003cdiv class=\"pp-title\" id=\"pp-skin-types\"\u003e\n\u003cspan class=\"eyebrow\"\u003e07\u003c\/span\u003e\u003ch2\u003eSkin type compatibility\u003c\/h2\u003e\n\u003cspan class=\"num\"\u003eSKIN TYPES\u003c\/span\u003e\n\u003c\/div\u003e\u003c\/motion-element\u003e\n\n\u003cdiv class=\"pp-skin-grid\"\u003e\n\u003cdiv class=\"pp-skin-card\"\u003e\n\u003cdiv class=\"row\"\u003e\n\u003cdiv class=\"type\"\u003eOily \/ Acne-Prone\u003c\/div\u003e\n\u003cspan class=\"rate excellent\"\u003eExcellent\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"meter tier-good\"\u003e\n\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cp class=\"note\"\u003eThe primary target population. Winlevi directly reduces androgen-driven sebum overproduction — the core driver of oily, acne-prone skin. Most effective for seborrheic, cystic, or comedonal acne rooted in hormonal activity.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-skin-card\"\u003e\n\u003cdiv class=\"row\"\u003e\n\u003cdiv class=\"type\"\u003eCombination Skin\u003c\/div\u003e\n\u003cspan class=\"rate excellent\"\u003eExcellent\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"meter tier-good\"\u003e\n\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cp class=\"note\"\u003eWorks particularly well on the oily T-zone and hormonal breakout zones (chin, jawline). The moisturizing cream base prevents over-drying of drier areas of the face during treatment.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-skin-card\"\u003e\n\u003cdiv class=\"row\"\u003e\n\u003cdiv class=\"type\"\u003eDry Skin\u003c\/div\u003e\n\u003cspan class=\"rate good\"\u003eGood\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"meter tier-good\"\u003e\n\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan\u003e\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cp class=\"note\"\u003eThe emollient cream base with mineral oil and cetyl alcohol is gentler on dry skin than retinoids or benzoyl peroxide. A good moisturizer layered on top completes the routine comfortably.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-skin-card\"\u003e\n\u003cdiv class=\"row\"\u003e\n\u003cdiv class=\"type\"\u003eSensitive Skin\u003c\/div\u003e\n\u003cspan class=\"rate moderate\"\u003eModerate\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"meter tier-good\"\u003e\n\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan\u003e\u003c\/span\u003e\u003cspan\u003e\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cp class=\"note\"\u003eFragrance-free and paraben-free, but propylene glycol (at ~25%) can cause stinging or tingling on reactive or barrier-compromised skin. Patch test first; watch for redness, scaling, or itching.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-skin-card\"\u003e\n\u003cdiv class=\"row\"\u003e\n\u003cdiv class=\"type\"\u003eNormal Skin\u003c\/div\u003e\n\u003cspan class=\"rate good\"\u003eGood\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"meter tier-good\"\u003e\n\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan\u003e\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cp class=\"note\"\u003eWell tolerated on normal skin types. The moisturizing base maintains skin balance; mild side effects (trace erythema, mild scaling) were similar to vehicle cream in clinical trials.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cmotion-element data-motion=\"fade-up\" data-motion-delay=\"150\"\u003e\u003cdiv class=\"pp-title\" id=\"pp-results\"\u003e\n\u003cspan class=\"eyebrow\"\u003e08\u003c\/span\u003e\u003ch2\u003eResults timeline\u003c\/h2\u003e\n\u003cspan class=\"num\"\u003e3–6 MONTHS\u003c\/span\u003e\n\u003c\/div\u003e\u003c\/motion-element\u003e\n\n\u003cdiv class=\"pp-timeline\"\u003e\n\u003cdiv class=\"pp-tl-item\"\u003e\n\u003cspan class=\"time\"\u003eWeeks 1–2\u003c\/span\u003e\n\u003ch4\u003eInitial Adjustment Phase\u003c\/h4\u003e\n\u003cp\u003eSome users report mild redness, scaling, or tingling as skin adjusts to the formula. Unlike retinoids, there is no traditional \"purging\" phase with clascoterone. Skin begins acclimating to twice-daily application. Keep your routine simple and moisturize well.\u003c\/p\u003e\n\u003cspan class=\"percent\"\u003eEarly tolerance building\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-tl-item\"\u003e\n\u003cspan class=\"time\"\u003eWeeks 4–6\u003c\/span\u003e\n\u003ch4\u003eFirst Noticeable Improvements\u003c\/h4\u003e\n\u003cp\u003eMany patients begin to see fewer new breakouts forming and a reduction in inflammatory lesion severity. Sebum production may noticeably decrease. The brand website notes users can start seeing improvements around week 4.\u003c\/p\u003e\n\u003cspan class=\"percent\"\u003e~40% notice initial changes\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-tl-item\"\u003e\n\u003cspan class=\"time\"\u003eWeeks 8–12\u003c\/span\u003e\n\u003ch4\u003eMeasurable Lesion Reduction\u003c\/h4\u003e\n\u003cp\u003eThe primary study endpoint was 12 weeks. Phase 3 data showed a mean reduction of ~19 inflammatory lesions and ~19 non-inflammatory lesions from baseline. Treatment success (IGA 0\/1) achieved by 18–20% of patients in pivotal trials.\u003c\/p\u003e\n\u003cspan class=\"percent\"\u003e18–20% IGA success (vs 6–9% vehicle)\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-tl-item\"\u003e\n\u003cspan class=\"time\"\u003e3–6 Months\u003c\/span\u003e\n\u003ch4\u003eSustained Acne Control\u003c\/h4\u003e\n\u003cp\u003eWith continued twice-daily use, Winlevi maintains androgen receptor blockade at the follicle level, helping prevent future breakouts. The 12-month open-label extension study confirmed the sustained safety profile with ongoing use.\u003c\/p\u003e\n\u003cspan class=\"percent\"\u003eLong-term maintenance benefit\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cmotion-element data-motion=\"fade-up\" data-motion-delay=\"200\"\u003e\u003cdiv class=\"pp-title\" id=\"pp-reviews\"\u003e\n\u003cspan class=\"eyebrow\"\u003e09\u003c\/span\u003e\u003ch2\u003eRatings by platform\u003c\/h2\u003e\n\u003cspan class=\"num\"\u003e92+ REVIEWS\u003c\/span\u003e\n\u003c\/div\u003e\u003c\/motion-element\u003e\n\n\u003cdiv class=\"pp-reviews\"\u003e\n\u003cdiv class=\"pp-review-card\"\u003e\n\u003cdiv class=\"platform\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-shield-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003eWebMD Patient Reviews\u003c\/div\u003e\n\u003cdiv class=\"stats\"\u003e\n\u003cdiv class=\"stat\"\u003e\n\u003cdiv class=\"num\"\u003e\n\u003cdiv class=\"meter\"\u003e\n\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\n\u003c\/div\u003e 3.0\u003c\/div\u003e\n\u003cdiv class=\"lbl\"\u003eRating\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"stat\"\u003e\n\u003cdiv class=\"num\"\u003e42+\u003c\/div\u003e\n\u003cdiv class=\"lbl\"\u003eReviews\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"complaint\"\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\" style=\"display:inline-block;width:14px;height:14px;vertical-align:middle\"\u003e\u003cuse href=\"#i-info\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Main complaints: Thick\/greasy texture difficult to blend, some users experienced worsening cystic acne, high cost without insurance, and irregular periods in a subset of female users.\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-review-card\"\u003e\n\u003cdiv class=\"platform\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-shield-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003eDrugs.com Patient Ratings\u003c\/div\u003e\n\u003cdiv class=\"stats\"\u003e\n\u003cdiv class=\"stat\"\u003e\n\u003cdiv class=\"num\"\u003e\n\u003cdiv class=\"meter\"\u003e\n\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\n\u003c\/div\u003e 4.2\u003c\/div\u003e\n\u003cdiv class=\"lbl\"\u003eRating\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"stat\"\u003e\n\u003cdiv class=\"num\"\u003e50+\u003c\/div\u003e\n\u003cdiv class=\"lbl\"\u003eReviews\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"complaint\"\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\" style=\"display:inline-block;width:14px;height:14px;vertical-align:middle\"\u003e\u003cuse href=\"#i-info\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Main complaints: Slow results requiring patient commitment, white cast\/residue after application, and frustration with insurance coverage barriers.\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-review-card\"\u003e\n\u003cdiv class=\"platform\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-shield-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003eWinlevi.com (Brand Site)\u003c\/div\u003e\n\u003cdiv class=\"stats\"\u003e\n\u003cdiv class=\"stat\"\u003e\n\u003cdiv class=\"num\"\u003ePhase 3\u003c\/div\u003e\n\u003cdiv class=\"lbl\"\u003eTrials\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"stat\"\u003e\n\u003cdiv class=\"num\"\u003e1,440\u003c\/div\u003e\n\u003cdiv class=\"lbl\"\u003ePatients\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"complaint\"\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\" style=\"display:inline-block;width:14px;height:14px;vertical-align:middle\"\u003e\u003cuse href=\"#i-info\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Clinical note: Treatment success defined as IGA 0 or 1 achieved in 18–20% of patients vs. 6–9% vehicle. Requires full 12-week commitment for meaningful results per the clinical data.\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-review-card\"\u003e\n\u003cdiv class=\"platform\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-sparkle\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003eReddit r\/SkincareAddiction\u003c\/div\u003e\n\u003cdiv class=\"stats\"\u003e\n\u003cdiv class=\"stat\"\u003e\n\u003cdiv class=\"num\"\u003eMixed\u003c\/div\u003e\n\u003cdiv class=\"lbl\"\u003eConsensus\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"stat\"\u003e\n\u003cdiv class=\"num\"\u003eRx Only\u003c\/div\u003e\n\u003cdiv class=\"lbl\"\u003eAccess\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"complaint\"\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\" style=\"display:inline-block;width:14px;height:14px;vertical-align:middle\"\u003e\u003cuse href=\"#i-info\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Common thread: Works best as part of a combination protocol (e.g., paired with a retinoid or benzoyl peroxide). Solo use results are variable, especially for severe cystic acne.\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cmotion-element data-motion=\"fade-up\" data-motion-delay=\"0\"\u003e\u003cdiv class=\"pp-title\" id=\"pp-pros-cons\"\u003e\n\u003cspan class=\"eyebrow\"\u003e10\u003c\/span\u003e\u003ch2\u003ePros \u0026amp; cons\u003c\/h2\u003e\n\u003cspan class=\"num\"\u003eBALANCED\u003c\/span\u003e\n\u003c\/div\u003e\u003c\/motion-element\u003e\n\n\u003cdiv class=\"pp-proscons\"\u003e\n\u003cdiv class=\"pp-pc pros\"\u003e\n\u003ch4\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003ePraised\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Unique mechanism: only topical antiandrogen available\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Approved for both males and females (unlike oral spiro)\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Non-drying cream base — gentler than retinoids\/BPO\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e No antibiotic resistance concerns\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Fragrance-free, paraben-free formula\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Minimal systemic absorption — localized action\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Non-comedogenic (mineral oil + cetyl alcohol: 1–2\/5)\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Clinically proven in two robust Phase 3 trials (N=1,440)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-pc cons\"\u003e\n\u003ch4\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-x\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003eCriticized\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-x\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Very expensive (~$580\/60g without insurance)\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-x\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Prescription-only — requires healthcare provider visit\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-x\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Rich, creamy texture can leave white residue or streaks\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-x\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Contains Polysorbate 80 — NOT fungal acne safe\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-x\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Results require 8–12 weeks of consistent twice-daily use\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-x\"\u003e\u003c\/use\u003e\u003c\/svg\u003e HPA axis suppression possible with extended use\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-x\"\u003e\u003c\/use\u003e\u003c\/svg\u003e IGA success rate ~18–20% — not a \"cure-all\"\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-x\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Pregnancy and breastfeeding safety not established\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cmotion-element data-motion=\"fade-up\" data-motion-delay=\"50\"\u003e\u003cdiv class=\"pp-title\" id=\"pp-dupes\"\u003e\n\u003cspan class=\"eyebrow\"\u003e11\u003c\/span\u003e\u003ch2\u003eBudget-friendly alternatives\u003c\/h2\u003e\n\u003cspan class=\"num\"\u003eDUPES\u003c\/span\u003e\n\u003c\/div\u003e\u003c\/motion-element\u003e\n\n\u003cdiv class=\"pp-dupes\"\u003e\n\u003cdiv class=\"pp-dupe-card\"\u003e\n\u003cspan class=\"match medium\"\u003e70% Match\u003c\/span\u003e\u003cdiv class=\"photo\"\u003e\u003cdiv class=\"photo-fallback\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-bottle\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv class=\"body\"\u003e\n\u003cdiv class=\"name\"\u003eCompounded Topical Spironolactone 5% Cream\u003c\/div\u003e\n\u003cdiv class=\"price-row\"\u003e\n\u003cdiv class=\"amount\"\u003e~$30–$60\u003c\/div\u003e\n\u003cdiv class=\"tag budget\"\u003eBudget Option\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp class=\"diff\"\u003eAvailable through compounding pharmacies with a prescription. Targets the same androgen pathway via mineralocorticoid receptor blockade. Less clinical evidence than Winlevi, not FDA-approved as a specific formulation, but widely used off-label by dermatologists — particularly for female patients.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-dupe-card\"\u003e\n\u003cspan class=\"match medium\"\u003e65% Match\u003c\/span\u003e\u003cdiv class=\"photo\"\u003e\u003cdiv class=\"photo-fallback\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-bottle\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv class=\"body\"\u003e\n\u003cdiv class=\"name\"\u003eOral Spironolactone 25–100mg (Generic)\u003c\/div\u003e\n\u003cdiv class=\"price-row\"\u003e\n\u003cdiv class=\"amount\"\u003e~$10–$20\/month\u003c\/div\u003e\n\u003cdiv class=\"tag budget\"\u003eBudget Option\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp class=\"diff\"\u003eThe systemic antiandrogen often compared to Winlevi. Highly effective for hormonal acne in females, but causes systemic effects including menstrual irregularities, blood pressure changes, and potassium fluctuations. Not usable in males due to feminizing side effects. Winlevi was specifically developed to offer spironolactone-like efficacy without systemic risks.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-dupe-card\"\u003e\n\u003cspan class=\"match low\"\u003e50% Match\u003c\/span\u003e\u003cdiv class=\"photo\"\u003e\u003ca href=\"https:\/\/www.skincarisma.com\/products\/adapalene-gel-0-4\" target=\"_blank\" rel=\"noopener\" style=\"display:block;width:100%;height:100%\"\u003e\u003cimg class=\"pp-product-photo\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0907\/5028\/8215\/files\/ej9756kxs6kxq05n0gylazqmvnh4_square_1ee2130f-844d-4aef-b967-cc76168634de.png?v=1776769397\" alt=\"Adapalene Gel 0.1%\" loading=\"lazy\" width=\"200\" height=\"200\" style=\"display:block;width:100%;height:100%;object-fit:cover\"\u003e\u003c\/a\u003e\u003c\/div\u003e\n\u003cdiv class=\"body\"\u003e\n\u003cdiv class=\"name\"\u003e\u003ca href=\"https:\/\/www.skincarisma.com\/products\/adapalene-gel-0-4\" target=\"_blank\" rel=\"noopener\" style=\"color:inherit;text-decoration:none\"\u003eAdapalene 0.1% Gel (Differin OTC)\u003c\/a\u003e\u003c\/div\u003e\n\u003cdiv class=\"price-row\"\u003e\n\u003cdiv class=\"amount\"\u003e~$15–$30\u003c\/div\u003e\n\u003cdiv class=\"tag budget\"\u003eOTC Option\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp class=\"diff\"\u003eA retinoid that works via a completely different mechanism — normalizing cell turnover and reducing follicular plugging. Available over the counter without a prescription. Does not target androgens or sebum production directly, but is highly effective for comedonal and mild-to-moderate acne. More drying than Winlevi; suitable as a companion product rather than a true alternative.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cmotion-element data-motion=\"fade-up\" data-motion-delay=\"100\"\u003e\u003cdiv class=\"pp-title\" id=\"pp-compare\"\u003e\n\u003cspan class=\"eyebrow\"\u003e12\u003c\/span\u003e\u003ch2\u003eComparison with competitors\u003c\/h2\u003e\n\u003cspan class=\"num\"\u003eSIDE-BY-SIDE\u003c\/span\u003e\n\u003c\/div\u003e\u003c\/motion-element\u003e\n\n\u003cdiv class=\"pp-compare\"\u003e\n\u003cdiv class=\"pp-compare-card featured\"\u003e\n\u003cdiv class=\"photo\"\u003e\u003ca href=\"https:\/\/www.skincarisma.com\/products\/clascoterone-cream-1\" target=\"_blank\" rel=\"noopener\" style=\"display:block;width:100%;height:100%\"\u003e\u003cimg class=\"pp-product-photo\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0907\/5028\/8215\/files\/1nkt7n5egymipz3ttd4fd0ln4j3q_square_6d9e13a3-4a86-45a8-b164-6c8a998e6b95.png?v=1777456025\" alt=\"Clascoterone Cream 1%\" loading=\"lazy\" width=\"200\" height=\"200\" style=\"display:block;width:100%;height:100%;object-fit:cover\"\u003e\u003c\/a\u003e\u003c\/div\u003e\n\u003cdiv class=\"head\"\u003e\n\u003ca href=\"https:\/\/www.skincarisma.com\/products\/clascoterone-cream-1\" target=\"_blank\" rel=\"noopener\" style=\"color:inherit;text-decoration:none\"\u003e\u003ch4\u003eWinlevi — Clascoterone 1% Cream (Featured)\u003c\/h4\u003e\u003c\/a\u003e\u003cdiv class=\"price\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"body\"\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eMechanism\u003c\/span\u003e\n\u003cspan class=\"value good\"\u003eTopical Androgen Receptor Inhibitor\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eApproved For\u003c\/span\u003e\n\u003cspan class=\"value good\"\u003eMales \u0026amp; Females 12+\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eFDA Approved\u003c\/span\u003e\n\u003cspan class=\"value good\"\u003eYes (2020, NDA 213433)\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eSystemic Side Effects\u003c\/span\u003e\n\u003cspan class=\"value good\"\u003eMinimal (local only)\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eTargets Sebum\u003c\/span\u003e\n\u003cspan class=\"value good\"\u003eYes — directly\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eAntibiotic Resistance Risk\u003c\/span\u003e\n\u003cspan class=\"value good\"\u003eNone\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003ePregnancy Safe\u003c\/span\u003e\n\u003cspan class=\"value neutral\"\u003eUnknown \/ Caution\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eFungal Acne Safe\u003c\/span\u003e\n\u003cspan class=\"value bad\"\u003eNo\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-card\"\u003e\n\u003cdiv class=\"photo\"\u003e\u003cdiv class=\"placeholder\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\" style=\"width:36px;height:36px;color:var(--pp-ink-3)\"\u003e\u003cuse href=\"#i-bottle\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv class=\"head\"\u003e\n\u003ch4\u003eTretinoin 0.025–0.1% Cream (Generic Retinoid)\u003c\/h4\u003e\n\u003cdiv class=\"price\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"body\"\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eMechanism\u003c\/span\u003e\n\u003cspan class=\"value neutral\"\u003eRetinoid (RAR Agonist) — Cell Turnover\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eApproved For\u003c\/span\u003e\n\u003cspan class=\"value neutral\"\u003eAcne + Photoaging; all genders\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eFDA Approved\u003c\/span\u003e\n\u003cspan class=\"value good\"\u003eYes (long-established)\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eSystemic Side Effects\u003c\/span\u003e\n\u003cspan class=\"value good\"\u003eMinimal topically\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eTargets Sebum\u003c\/span\u003e\n\u003cspan class=\"value neutral\"\u003eIndirectly (normalizes follicle)\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eAntibiotic Resistance Risk\u003c\/span\u003e\n\u003cspan class=\"value good\"\u003eNone\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003ePregnancy Safe\u003c\/span\u003e\n\u003cspan class=\"value bad\"\u003eNo — Contraindicated\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eFungal Acne Safe\u003c\/span\u003e\n\u003cspan class=\"value neutral\"\u003eCheck specific formulation\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-card\"\u003e\n\u003cdiv class=\"photo\"\u003e\u003ca href=\"https:\/\/www.skincarisma.com\/products\/clindamycin-and-benzoyl-peroxide-gel-1-5\" target=\"_blank\" rel=\"noopener\" style=\"display:block;width:100%;height:100%\"\u003e\u003cimg class=\"pp-product-photo\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0907\/5028\/8215\/files\/492v7xrd29s99wit964b0er1n5ra.jpg?v=1767016710\" alt=\"Clindamycin and Benzoyl Peroxide Gel 1%\/5%\" loading=\"lazy\" width=\"200\" height=\"200\" style=\"display:block;width:100%;height:100%;object-fit:cover\"\u003e\u003c\/a\u003e\u003c\/div\u003e\n\u003cdiv class=\"head\"\u003e\n\u003ca href=\"https:\/\/www.skincarisma.com\/products\/clindamycin-and-benzoyl-peroxide-gel-1-5\" target=\"_blank\" rel=\"noopener\" style=\"color:inherit;text-decoration:none\"\u003e\u003ch4\u003eClindamycin 1% + Benzoyl Peroxide 5% Gel (BenzaClin \/ Generic)\u003c\/h4\u003e\u003c\/a\u003e\u003cdiv class=\"price\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"body\"\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eMechanism\u003c\/span\u003e\n\u003cspan class=\"value neutral\"\u003eAntibiotic + Oxidant — Antibacterial\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eApproved For\u003c\/span\u003e\n\u003cspan class=\"value neutral\"\u003eInflammatory acne; all genders\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eFDA Approved\u003c\/span\u003e\n\u003cspan class=\"value good\"\u003eYes\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eSystemic Side Effects\u003c\/span\u003e\n\u003cspan class=\"value good\"\u003eVery low topically\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eTargets Sebum\u003c\/span\u003e\n\u003cspan class=\"value bad\"\u003eNo — targets bacteria only\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eAntibiotic Resistance Risk\u003c\/span\u003e\n\u003cspan class=\"value bad\"\u003eYes — clindamycin resistance possible\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003ePregnancy Safe\u003c\/span\u003e\n\u003cspan class=\"value neutral\"\u003eCaution — consult physician\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eFungal Acne Safe\u003c\/span\u003e\n\u003cspan class=\"value good\"\u003eGenerally yes (BPO kills Malassezia)\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-card\"\u003e\n\u003cdiv class=\"photo\"\u003e\u003cdiv class=\"placeholder\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\" style=\"width:36px;height:36px;color:var(--pp-ink-3)\"\u003e\u003cuse href=\"#i-bottle\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv class=\"head\"\u003e\n\u003ch4\u003eOral Spironolactone 50–100mg (Generic)\u003c\/h4\u003e\n\u003cdiv class=\"price\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"body\"\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eMechanism\u003c\/span\u003e\n\u003cspan class=\"value neutral\"\u003eSystemic Antiandrogen (Oral)\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eApproved For\u003c\/span\u003e\n\u003cspan class=\"value bad\"\u003eFemales only (off-label for acne)\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eFDA Approved (for acne)\u003c\/span\u003e\n\u003cspan class=\"value bad\"\u003eOff-label use\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eSystemic Side Effects\u003c\/span\u003e\n\u003cspan class=\"value bad\"\u003eYes — menstrual irregularity, BP changes, hyperkalemia\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eTargets Sebum\u003c\/span\u003e\n\u003cspan class=\"value good\"\u003eYes — systemically\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eAntibiotic Resistance Risk\u003c\/span\u003e\n\u003cspan class=\"value good\"\u003eNone\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003ePregnancy Safe\u003c\/span\u003e\n\u003cspan class=\"value bad\"\u003eContraindicated\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eFungal Acne Safe\u003c\/span\u003e\n\u003cspan class=\"value neutral\"\u003eN\/A (oral medication)\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cmotion-element data-motion=\"fade-up\" data-motion-delay=\"150\"\u003e\u003cdiv class=\"pp-title\" id=\"pp-storage\"\u003e\n\u003cspan class=\"eyebrow\"\u003e13\u003c\/span\u003e\u003ch2\u003eStorage \u0026amp; shelf life\u003c\/h2\u003e\n\u003cspan class=\"num\"\u003e12 MONTHS\u003c\/span\u003e\n\u003c\/div\u003e\u003c\/motion-element\u003e\n\n\u003cdiv class=\"pp-safety\"\u003e\n\u003cdiv class=\"pp-safety-item info\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-clock\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cstrong\u003ePeriod After Opening (PAO)\u003c\/strong\u003e\n\u003cp\u003e12 months after opening. Check the expiry date printed on the tube — do not use after the stated expiration date even if the tube has not been opened.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-safety-item info\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-shield-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cstrong\u003eStorage\u003c\/strong\u003e\n\u003cp\u003eStore at controlled room temperature — 68°F to 77°F (20°C to 25°C). Keep away from heat, direct sunlight, and humidity. Do not refrigerate or freeze. Keep out of reach of children.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-safety-item info\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-bottle\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cstrong\u003ePackaging\u003c\/strong\u003e\n\u003cp\u003eAluminum tube with screw cap, available in 30g (1 oz) and 60g (2 oz) sizes. The tube format minimizes contamination and oxidation compared to open jars. Apply by squeezing a small amount onto clean fingertips.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-safety-item info\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-package\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cstrong\u003eTravel Friendly\u003c\/strong\u003e\n\u003cp\u003eThe 30g tube qualifies as under 100ml and is compliant with TSA\/carry-on liquid restrictions. Place in a clear plastic bag with other liquids and gels for airport security screening.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cmotion-element data-motion=\"fade-up\" data-motion-delay=\"200\"\u003e\u003cdiv class=\"pp-title\" id=\"pp-faq\"\u003e\n\u003cspan class=\"eyebrow\"\u003e13\u003c\/span\u003e\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003cspan class=\"num\"\u003eFAQ\u003c\/span\u003e\n\u003c\/div\u003e\u003c\/motion-element\u003e\n\n\u003cdiv class=\"pp-faq\"\u003e\n\u003cdiv class=\"pp-faq-item\"\u003e\n\u003cinput type=\"checkbox\" id=\"faq1\"\u003e\n\u003clabel for=\"faq1\"\u003eIs Clascoterone Cream 1% (Winlevi) safe during pregnancy and breastfeeding?\u003c\/label\u003e\n\u003cdiv class=\"pp-faq-answer\"\u003e\n\u003cp\u003eSafety has not been established in pregnant or breastfeeding humans. Animal studies conducted with subcutaneous administration at doses 8 to 39 times the human dose demonstrated organ malformations in rat fetuses. It is also unknown whether clascoterone passes into breast milk. The prescribing label states: \"It is not known if WINLEVI cream will harm your unborn baby.\" If you are pregnant, planning to become pregnant, or breastfeeding, you should discuss with your healthcare provider before using this product. In general, Winlevi should be classified as Caution for pregnancy — avoid unless specifically directed by a physician who has weighed the risk-benefit profile.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-faq-item\"\u003e\n\u003cinput type=\"checkbox\" id=\"faq2\"\u003e\n\u003clabel for=\"faq2\"\u003eIs Clascoterone Cream 1% (Winlevi) safe for fungal acne (Malassezia folliculitis)?\u003c\/label\u003e\n\u003cdiv class=\"pp-faq-answer\"\u003e\n\u003cp\u003eNo — Winlevi is NOT safe for fungal acne. The formulation contains two ingredients that are known to feed Malassezia yeast: Polysorbate 80 (a polyoxyethylene sorbitan ester) and Mono and Diglycerides (fatty acid glycerol esters). Both of these can serve as a nutrient source for Malassezia furfur, the organism responsible for pityrosporum folliculitis. If you suspect you have fungal acne — characterized by small, uniform, itchy papules and pustules often on the forehead, temples, or chest — consult your dermatologist before starting Winlevi. An antifungal treatment and a Malassezia-safe acne protocol would be more appropriate.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-faq-item\"\u003e\n\u003cinput type=\"checkbox\" id=\"faq3\"\u003e\n\u003clabel for=\"faq3\"\u003eCan I use Winlevi with retinol, vitamin C, AHA\/BHA, or other actives?\u003c\/label\u003e\n\u003cdiv class=\"pp-faq-answer\"\u003e\n\u003cp\u003eWinlevi can be combined with other topical actives, but caution and timing are important. The prescribing information advises limiting the use of other potentially irritating topical products alongside Winlevi — specifically: medicated or abrasive soaps, cleansers with strong drying effects, high-concentration alcohol products, astringents, and products containing spices or lime. Retinoids (tretinoin, adapalene) can be used in the same regimen but ideally at different application times (e.g., Winlevi in the AM, retinoid in the PM) to minimize cumulative irritation. Similarly, AHAs, BHAs, or vitamin C serums should be used at a different time of day if concurrent irritation occurs. There are no known pharmacokinetic drug interactions; no significant effects on CYP enzymes were found in vitro. Always introduce one new active at a time and monitor for skin barrier disruption.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-faq-item\"\u003e\n\u003cinput type=\"checkbox\" id=\"faq4\"\u003e\n\u003clabel for=\"faq4\"\u003eWhat skin type is Clascoterone Cream 1% (Winlevi) best for?\u003c\/label\u003e\n\u003cdiv class=\"pp-faq-answer\"\u003e\n\u003cp\u003eWinlevi is best suited for oily and combination skin types with moderate-to-severe hormonal acne (IGA score 3–4). It is particularly effective for patients experiencing androgen-driven breakouts — characterized by deep, inflamed pimples concentrated along the jawline, chin, and lower cheeks, often worsening with hormonal fluctuations (menstrual cycle, puberty, stress). The cream base makes it more tolerable than retinoids for dry skin types, but the propylene glycol content (~25%) can cause minor stinging on sensitive or barrier-compromised skin. It is not ideal for fungal acne, regardless of skin type. Best results are seen in patients with moderate-to-severe inflammatory or mixed (inflammatory + comedonal) facial acne with a hormonal component.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-faq-item\"\u003e\n\u003cinput type=\"checkbox\" id=\"faq5\"\u003e\n\u003clabel for=\"faq5\"\u003eHow long until I see results from Clascoterone Cream (Winlevi)?\u003c\/label\u003e\n\u003cdiv class=\"pp-faq-answer\"\u003e\n\u003cp\u003eInitial improvements may be noticed around 4 weeks of consistent twice-daily use. However, the pivotal Phase 3 clinical trials assessed outcomes at 12 weeks — and this is the timeframe used to evaluate meaningful clinical efficacy. Statistically significant reductions in both inflammatory lesion counts (~19 lesions from baseline) and non-inflammatory lesions were demonstrated at week 12. Treatment success (IGA 0 or 1, i.e., clear or almost clear) was achieved in 18–20% of patients versus 6–9% in the vehicle group. It is important to maintain a consistent twice-daily routine for a full 12 weeks before evaluating whether the treatment is working for you. Do not discontinue prematurely — like most prescription acne treatments, early patience is required.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-faq-item\"\u003e\n\u003cinput type=\"checkbox\" id=\"faq6\"\u003e\n\u003clabel for=\"faq6\"\u003eWhere does Winlevi go in my skincare routine?\u003c\/label\u003e\n\u003cdiv class=\"pp-faq-answer\"\u003e\n\u003cp\u003eWinlevi is applied after cleansing and before moisturizer, twice daily — morning and evening. The correct routine order is: (1) Gentle Cleanser → (2) Optional Toner → (3) Winlevi Cream (applied to clean, dry skin, ~1g \/ 2 fingertip units) → (4) Moisturizer → (5) Sunscreen (AM only). Wait 1–2 minutes after applying Winlevi before layering moisturizer. Avoid using harsh, drying, or alcohol-heavy products immediately after application. Unlike retinoids, Winlevi can be used in the morning without photosensitivity concerns, making the twice-daily protocol more flexible.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-faq-item\"\u003e\n\u003cinput type=\"checkbox\" id=\"faq7\"\u003e\n\u003clabel for=\"faq7\"\u003eIs Clascoterone Cream (Winlevi) comedogenic? Will it clog pores?\u003c\/label\u003e\n\u003cdiv class=\"pp-faq-answer\"\u003e\n\u003cp\u003eWinlevi has a comedogenic rating of approximately 2\/5 — considered low. The key potentially comedogenic ingredients are cetyl alcohol (rated 2\/5) and mineral oil (rated 0–1\/5 for cosmetic-grade formulations). In practice, because Winlevi directly reduces androgen-driven sebum production, it generally helps to reduce the conditions that lead to comedones rather than worsen them. Some user reviews do mention clogged pores or new comedones during early use — this may reflect the initial adjustment period or the cream base interacting with individual skin chemistry. For users with highly comedone-prone skin, discuss with your dermatologist and monitor response during the first 4 weeks. The formula does not contain any heavy waxes, butters, or high-rated comedogenic oils.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-faq-item\"\u003e\n\u003cinput type=\"checkbox\" id=\"faq8\"\u003e\n\u003clabel for=\"faq8\"\u003eHow long does Winlevi Cream last after opening?\u003c\/label\u003e\n\u003cdiv class=\"pp-faq-answer\"\u003e\n\u003cp\u003eWinlevi Cream should be used within 12 months of opening. At twice-daily whole-face application (~1g per application), a 30g tube lasts approximately 2 weeks and a 60g tube approximately 4 weeks with consistent use. Store at room temperature (68–77°F \/ 20–25°C), away from heat and direct sunlight. Always check the expiry date on the tube. Do not use after the printed expiration date regardless of whether the tube has been opened. Keep the cap tightly closed after each use to prevent contamination and oxidative degradation of the formula.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"pp-verdict\"\u003e\n    \u003cdiv class=\"eyebrow\"\u003e— Skincarisma verdict\u003c\/div\u003e\n    \u003cdiv class=\"score-row\"\u003e\n      \u003cspan class=\"score\"\u003e4.0\u003c\/span\u003e\n      \u003cspan class=\"max\"\u003e\/ 5\u003c\/span\u003e\n      \u003cspan class=\"stars\"\u003e★★★★☆\u003c\/span\u003e\n    \u003c\/div\u003e\n    \u003cp class=\"text\"\u003e\n\u003cstrong\u003eVerdict:\u003c\/strong\u003e Winlevi (Clascoterone 1%) is a genuinely groundbreaking prescription acne treatment — the first and only FDA-approved topical androgen receptor inhibitor for acne vulgaris. For patients with moderate-to-severe hormonal acne who have not achieved adequate control with retinoids, antibiotics, or oral contraceptives, Winlevi offers a novel and locally-targeted mechanism with minimal systemic risk. It is particularly valuable for male patients, who cannot use oral antiandrogens like spironolactone. The cream base is gentler than most acne treatments, and the twice-daily protocol is straightforward. The key limitations are the high cost (~$580 without insurance), the prescription-only requirement, and the fact that results require 12 weeks of consistent use — with modest IGA success rates of 18–20% in clinical trials. It works best as part of a multi-modal regimen rather than as monotherapy.\u003cstrong\u003eNot recommended for fungal acne or pregnancy.\u003c\/strong\u003e For hormonal acne in appropriate candidates, Winlevi is a meaningful clinical advance worth discussing with a dermatologist.\n\u003c\/p\u003e\n  \u003c\/div\u003e\n\n  \u003cbutton class=\"pp-back-to-top\" aria-label=\"Back to top\" type=\"button\" style=\"position:fixed;bottom:24px;right:24px;width:44px;height:44px;border-radius:50%;background:var(--pp-accent);color:#fff;border:none;display:none;cursor:pointer;z-index:50;box-shadow:0 4px 16px rgba(13,31,45,0.2)\"\u003e↑\u003c\/button\u003e\n  \u003cscript\u003e\n  (function () {\n    var btt = document.querySelector('.pp-back-to-top');\n    if (!btt) return;\n    var ticking = false;\n    function onScroll () {\n      if (!ticking) {\n        requestAnimationFrame(function () {\n          btt.style.display = window.scrollY \u003e 600 ? 'block' : 'none';\n          ticking = false;\n        });\n        ticking = true;\n      }\n    }\n    window.addEventListener('scroll', onScroll, { passive: true });\n    btt.addEventListener('click', function () { window.scrollTo({ top: 0, behavior: 'smooth' }); });\n  })();\n  \u003c\/script\u003e\n\u003c\/div\u003e\n","brand":"Winlevi","offers":[{"title":"Default Title","offer_id":52105280356695,"sku":null,"price":508.55,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0907\/5028\/8215\/files\/1nkt7n5egymipz3ttd4fd0ln4j3q_square_6d9e13a3-4a86-45a8-b164-6c8a998e6b95.png?v=1777456025","url":"https:\/\/www.skincarisma.com\/products\/clascoterone-cream-1","provider":"Skincarisma","version":"1.0","type":"link"}