{"product_id":"duac-once-daily-10mg-g-50mg-g-gel","title":"Duac Once Daily 10mg\/g + 50mg\/g Gel","description":"\u003cdiv class=\"pp\" lang=\"en\" itemscope itemtype=\"https:\/\/schema.org\/Product\"\u003e\n  \u003cmeta itemprop=\"name\" content=\"Stiefel Laboratories, Inc. Duac Once Daily 10mg\/g + 50mg\/g Gel\"\u003e\n  \u003cmeta itemprop=\"brand\" content=\"Stiefel Laboratories, Inc.\"\u003e\n  \u003cmeta itemprop=\"category\" content=\"Skincare \u0026gt; Acne Treatment\"\u003e\n  \u003cmeta itemprop=\"countryOfOrigin\" content=\"Various\"\u003e\n\n  \u003cscript type=\"application\/ld+json\"\u003e{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@graph\": [\n    {\n      \"@type\": \"FAQPage\",\n      \"mainEntity\": [\n        {\n          \"@type\": \"Question\",\n          \"name\": \"Is Duac Once Daily Gel pregnancy and breastfeeding safe?\",\n          \"acceptedAnswer\": {\n            \"@type\": \"Answer\",\n            \"text\": \"Use with caution. According to the official Stiefel\/GSK Summary of Product Characteristics, there are no adequate data from use in pregnant women, and animal reproductive studies have not been conducted with the combination. Duac should only be used during pregnancy if the expected benefit justifies the potential risk to the fetus. For breastfeeding, percutaneous absorption is low, but it is not known whether clindamycin or benzoyl peroxide passes into human milk via topical use. Do not apply to the breast area while nursing. Always consult your obstetrician or dermatologist before use.\"\n          }\n        },\n        {\n          \"@type\": \"Question\",\n          \"name\": \"Is Duac Once Daily Gel fungal acne (Malassezia) safe?\",\n          \"acceptedAnswer\": {\n            \"@type\": \"Answer\",\n            \"text\": \"Yes. The Duac formulation contains no fatty acids, fatty alcohols, esters, polysorbates, or oils that feed Malassezia yeast (the organism responsible for pityrosporum folliculitis \/ fungal acne). The ingredient list — clindamycin phosphate, benzoyl peroxide, carbomer, dimethicone, disodium lauryl sulfosuccinate, disodium EDTA, glycerin, silica, poloxamer 182, water, and sodium hydroxide — is considered fungal-acne-trigger-free. Benzoyl peroxide also has some antifungal activity, which may help if you have mixed bacterial and fungal acne.\"\n          }\n        },\n        {\n          \"@type\": \"Question\",\n          \"name\": \"Can I use Duac with retinol, vitamin C, AHA, or BHA?\",\n          \"acceptedAnswer\": {\n            \"@type\": \"Answer\",\n            \"text\": \"Layering requires care. Per the manufacturer's SPC, simultaneous application with tretinoin, isotretinoin, and tazarotene should be avoided because benzoyl peroxide can oxidize and inactivate retinoids and increase irritation. If your dermatologist prescribes both, apply them at different times of day (e.g., retinoid AM, Duac PM, or vice versa). For vitamin C: benzoyl peroxide can also oxidize L-ascorbic acid, so separate them by AM\/PM. AHA\/BHA exfoliants can multiply irritation when stacked with Duac — most dermatologists recommend pausing them during the first 4–6 weeks of treatment. Never combine Duac with topical or oral erythromycin due to drug antagonism.\"\n          }\n        },\n        {\n          \"@type\": \"Question\",\n          \"name\": \"What skin type is Duac best for?\",\n          \"acceptedAnswer\": {\n            \"@type\": \"Answer\",\n            \"text\": \"Duac performs best on oily, combination, and acne-prone skin with mild to moderate inflammatory acne (red papules and pustules). It is the gold-standard prescription combination for these skin profiles. Dry and sensitive skin types can use it but should expect significant initial dryness, redness, and peeling — pair with a fragrance-free moisturizer and consider a lower-strength alternative such as Acanya (BPO 2.5%) or Onexton (BPO 3.75%). Avoid if you have rosacea, active eczema, or known allergy to clindamycin\/lincomycin.\"\n          }\n        },\n        {\n          \"@type\": \"Question\",\n          \"name\": \"How long until I see results from Duac?\",\n          \"acceptedAnswer\": {\n            \"@type\": \"Answer\",\n            \"text\": \"The official Stiefel patient information leaflet states it may take 2–5 weeks to see the effect of Duac Once Daily Gel. In the five randomized Phase 3 clinical trials with 397 subjects, the primary efficacy endpoint was measured at week 11, with significant reductions in inflammatory lesion counts at lesion check-ins on weeks 2, 5, 8, and 11. Most users report visibly fewer breakouts within 3–4 weeks of consistent nightly use. Do not exceed 12 weeks of continuous use without a medical review.\"\n          }\n        },\n        {\n          \"@type\": \"Question\",\n          \"name\": \"Where does Duac go in my skincare routine?\",\n          \"acceptedAnswer\": {\n            \"@type\": \"Answer\",\n            \"text\": \"Duac is an evening (PM) treatment applied after cleansing and before moisturizing. The recommended sequence is: (1) gentle, fragrance-free cleanser, (2) wait 10–20 minutes for skin to fully dry, (3) apply a thin layer of Duac to the entire affected area, (4) wait 5 minutes, (5) apply a non-comedogenic moisturizer. In the morning, cleanse, moisturize, and always finish with broad-spectrum SPF 30+ — benzoyl peroxide significantly increases UV sensitivity. Do not layer Duac with retinoids or vitamin C in the same session.\"\n          }\n        },\n        {\n          \"@type\": \"Question\",\n          \"name\": \"Is Duac comedogenic — will it clog my pores?\",\n          \"acceptedAnswer\": {\n            \"@type\": \"Answer\",\n            \"text\": \"No. Duac has a comedogenic rating of 0\/5. The aqueous gel base contains no oils, butters, or comedogenic emollients. The inactive ingredients (carbomer, dimethicone, glycerin, silica, poloxamer 182, water, sodium hydroxide, disodium EDTA, disodium lauryl sulfosuccinate) are all rated 0–1 on standard comedogenicity scales. The active ingredients themselves — clindamycin and benzoyl peroxide — actively unclog pores rather than blocking them. If you experience purging in the first 2 weeks, this is the product surfacing existing clogs rather than creating new ones.\"\n          }\n        },\n        {\n          \"@type\": \"Question\",\n          \"name\": \"How long does Duac last after opening?\",\n          \"acceptedAnswer\": {\n            \"@type\": \"Answer\",\n            \"text\": \"Duac Once Daily Gel has a Period After Opening (PAO) of 2 months at room temperature once dispensed by the pharmacy. Per the Stiefel labeling, it should be stored at room temperature up to 25°C (77°F) and never frozen. Prior to dispensing, the pharmacy stores it refrigerated at 2–8°C (36–46°F) to preserve potency. Discard any remaining gel 60 days after the dispensing date — benzoyl peroxide degrades over time and loses efficacy. Always check the expiry date stamped on the tube crimp before use.\"\n          }\n        },\n        {\n          \"@type\": \"Question\",\n          \"name\": \"Will Duac bleach my towels and pillowcases?\",\n          \"acceptedAnswer\": {\n            \"@type\": \"Answer\",\n            \"text\": \"Yes. Benzoyl peroxide is a strong oxidizer and will permanently bleach colored fabrics, towels, pillowcases, hair, and carpeting on contact. To avoid damage: (1) use white pillowcases and towels during your Duac treatment, (2) wash your hands thoroughly after each application, (3) allow the gel to fully absorb (5–10 minutes) before contact with bedding, and (4) be cautious around dark clothing and dyed hair. The bleaching is irreversible — even a small smudge will leave a permanent orange or white mark.\"\n          }\n        }\n      ]\n    },\n    {\n      \"@type\": \"HowTo\",\n      \"name\": \"How to use Stiefel Laboratories, Inc. Duac Once Daily 10mg\/g + 50mg\/g Gel\",\n      \"totalTime\": \"PT2M\",\n      \"step\": [\n        {\n          \"@type\": \"HowToStep\",\n          \"position\": 1,\n          \"name\": \"Cleanse Gently\",\n          \"text\": \"Wash the affected area with a mild, fragrance-free cleanser. Rinse with warm water and pat (not rub) skin dry.\"\n        },\n        {\n          \"@type\": \"HowToStep\",\n          \"position\": 2,\n          \"name\": \"Wait 10–20 Minutes\",\n          \"text\": \"Let skin fully dry before application — applying to damp skin significantly increases stinging and irritation risk.\"\n        },\n        {\n          \"@type\": \"HowToStep\",\n          \"position\": 3,\n          \"name\": \"Apply a Pea-Sized Amount\",\n          \"text\": \"Use a fingertip-length of gel for the entire face. Apply once daily in the evening to all acne-prone areas, not just spots.\"\n        },\n        {\n          \"@type\": \"HowToStep\",\n          \"position\": 4,\n          \"name\": \"Spread a Thin Layer\",\n          \"text\": \"If the gel doesn't rub in easily, you're using too much. Avoid eyes, lips, nostrils, and mucous membranes.\"\n        },\n        {\n          \"@type\": \"HowToStep\",\n          \"position\": 5,\n          \"name\": \"Wash Hands Thoroughly\",\n          \"text\": \"Benzoyl peroxide will bleach hair and fabrics on contact — wash hands and avoid touching colored materials.\"\n        },\n        {\n          \"@type\": \"HowToStep\",\n          \"position\": 6,\n          \"name\": \"Follow With Moisturizer\",\n          \"text\": \"Wait 5 minutes, then apply a non-comedogenic, fragrance-free moisturizer to offset dryness and protect the barrier.\"\n        },\n        {\n          \"@type\": \"HowToStep\",\n          \"position\": 7,\n          \"name\": \"Daily Sunscreen (AM)\",\n          \"text\": \"Apply broad-spectrum SPF 30+ every morning. Benzoyl peroxide increases UV sensitivity and risk of irritation.\"\n        }\n      ]\n    },\n    {\n      \"@type\": \"ItemList\",\n      \"name\": \"Stiefel Laboratories, Inc. 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\"name\": \"Glycerin\"\n        },\n        {\n          \"@type\": \"ListItem\",\n          \"position\": 8,\n          \"name\": \"Silica\"\n        },\n        {\n          \"@type\": \"ListItem\",\n          \"position\": 9,\n          \"name\": \"Poloxamer 182\"\n        },\n        {\n          \"@type\": \"ListItem\",\n          \"position\": 10,\n          \"name\": \"Water (Purified)\"\n        },\n        {\n          \"@type\": \"ListItem\",\n          \"position\": 11,\n          \"name\": \"Sodium Hydroxide.\"\n        }\n      ]\n    }\n  ]\n}\u003c\/script\u003e\n\n  \u003csvg width=\"0\" height=\"0\" style=\"position:absolute\" aria-hidden=\"true\" focusable=\"false\"\u003e\n    \u003cdefs\u003e\n      \u003csymbol id=\"i-check\" viewbox=\"0 0 24 24\"\u003e\u003cpolyline points=\"20 6 9 17 4 12\"\u003e\u003c\/polyline\u003e\u003c\/symbol\u003e\n      \u003csymbol id=\"i-x\" viewbox=\"0 0 24 24\"\u003e\u003cline x1=\"18\" y1=\"6\" x2=\"6\" 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24\"\u003e\u003cpath d=\"M20 8l-8-4-8 4v8l8 4 8-4V8z\"\u003e\u003c\/path\u003e\u003cline x1=\"4\" y1=\"8\" x2=\"20\" y2=\"8\"\u003e\u003c\/line\u003e\u003cline x1=\"12\" y1=\"12\" x2=\"12\" y2=\"20\"\u003e\u003c\/line\u003e\u003c\/symbol\u003e\n      \u003csymbol id=\"i-calendar\" viewbox=\"0 0 24 24\"\u003e\u003crect x=\"3\" y=\"5\" width=\"18\" height=\"16\" rx=\"2\"\u003e\u003c\/rect\u003e\u003cline x1=\"3\" y1=\"10\" x2=\"21\" y2=\"10\"\u003e\u003c\/line\u003e\u003cline x1=\"8\" y1=\"3\" x2=\"8\" y2=\"7\"\u003e\u003c\/line\u003e\u003cline x1=\"16\" y1=\"3\" x2=\"16\" y2=\"7\"\u003e\u003c\/line\u003e\u003c\/symbol\u003e\n      \u003csymbol id=\"i-home\" viewbox=\"0 0 24 24\"\u003e\u003cpath d=\"M3 11l9-7 9 7v9a2 2 0 01-2 2h-4v-7H9v7H5a2 2 0 01-2-2v-9z\"\u003e\u003c\/path\u003e\u003c\/symbol\u003e\n      \u003csymbol id=\"i-plane\" viewbox=\"0 0 24 24\"\u003e\u003cpath d=\"M22 12l-9 4-3 6-2-5-5-2 6-3 4-9 9 9z\"\u003e\u003c\/path\u003e\u003c\/symbol\u003e\n      \u003csymbol id=\"i-arrow-right\" viewbox=\"0 0 24 24\"\u003e\u003cline x1=\"5\" y1=\"12\" x2=\"19\" y2=\"12\"\u003e\u003c\/line\u003e\u003cpolyline points=\"12 5 19 12 12 19\"\u003e\u003c\/polyline\u003e\u003c\/symbol\u003e\n    \u003c\/defs\u003e\n  \u003c\/svg\u003e\n\n  \n  \u003csection id=\"pp-overview\" class=\"pp-hero\" aria-labelledby=\"pp-hero-title\"\u003e\n    \u003ch2 id=\"pp-hero-title\" class=\"pp-sr-only\" style=\"position:absolute;left:-10000px\"\u003eProduct overview\u003c\/h2\u003e\n    \u003cdiv class=\"pp-origin\"\u003e\n      \u003csvg class=\"pin\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-pin\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\n      \u003cspan class=\"text\"\u003eMade in Various\u003c\/span\u003e\n      \u003cspan class=\"dot\"\u003e\u003c\/span\u003e\n      \u003cspan class=\"tag\"\u003eINTERNATIONAL\u003c\/span\u003e\n    \u003c\/div\u003e\n    \u003cp class=\"pp-subtitle\"\u003eBy \u003cstrong\u003eStiefel Laboratories, Inc.\u003c\/strong\u003e (a GSK company). Duac Once Daily Gel is a clinically proven, prescription-strength topical treatment for inflammatory acne vulgaris. This dual-action aqueous gel pairs \u003cstrong\u003e1% clindamycin phosphate\u003c\/strong\u003e with \u003cstrong\u003e5% benzoyl peroxide\u003c\/strong\u003e in a single, once-daily application — the antibiotic targets acne-causing bacteria while benzoyl peroxide unclogs pores and prevents resistance, delivering visibly clearer skin in as little as 2–5 weeks.\u003c\/p\u003e\n    \u003cdiv class=\"pp-badges\"\u003e\n\u003cspan class=\"pp-badge\"\u003e\u003csvg class=\"check\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Clinically Proven\u003c\/span\u003e\u003cspan class=\"pp-badge\"\u003e\u003csvg class=\"check\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Prescription Acne Treatment\u003c\/span\u003e\u003cspan class=\"pp-badge\"\u003e\u003csvg class=\"check\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Once-Daily Application\u003c\/span\u003e\u003cspan class=\"pp-badge\"\u003e\u003csvg class=\"check\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Dual-Action Formula\u003c\/span\u003e\u003cspan class=\"pp-badge\"\u003e\u003csvg class=\"check\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Fragrance-Free\u003c\/span\u003e\u003cspan class=\"pp-badge\"\u003e\u003csvg class=\"check\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Paraben-Free Variant Available\u003c\/span\u003e\u003cspan class=\"pp-badge\"\u003e\u003csvg class=\"check\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Non-Comedogenic Base\u003c\/span\u003e\u003cspan class=\"pp-badge\"\u003e\u003csvg class=\"check\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Ages 12+\u003c\/span\u003e\n\u003c\/div\u003e\n    \u003cnav class=\"pp-nav\" aria-label=\"Jump to product section\"\u003e\n      \u003cdiv class=\"pp-nav-head\"\u003eJump to section\u003c\/div\u003e\n      \u003cdiv class=\"pp-nav-list\"\u003e\n        \u003ca href=\"#pp-safety\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-shield-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003cspan class=\"lbl\"\u003eSafety\u003c\/span\u003e\u003csvg class=\"ico arrow\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-arrow-right\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/a\u003e\n        \u003ca href=\"#pp-ingredients\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-flask\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003cspan class=\"lbl\"\u003eIngredients\u003c\/span\u003e\u003csvg class=\"ico arrow\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-arrow-right\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/a\u003e\n        \u003ca href=\"#pp-routine\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-refresh\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003cspan class=\"lbl\"\u003eRoutine\u003c\/span\u003e\u003csvg class=\"ico arrow\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-arrow-right\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/a\u003e\n        \u003ca href=\"#pp-how-to-use\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-list\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003cspan class=\"lbl\"\u003eHow to use\u003c\/span\u003e\u003csvg class=\"ico arrow\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-arrow-right\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/a\u003e\n        \u003ca href=\"#pp-skin-types\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-target\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003cspan class=\"lbl\"\u003eSkin types\u003c\/span\u003e\u003csvg class=\"ico arrow\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-arrow-right\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/a\u003e\n        \u003ca href=\"#pp-results\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-trending\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003cspan class=\"lbl\"\u003eResults\u003c\/span\u003e\u003csvg class=\"ico arrow\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-arrow-right\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/a\u003e\n        \u003ca href=\"#pp-reviews\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-star\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003cspan class=\"lbl\"\u003eReviews\u003c\/span\u003e\u003csvg class=\"ico arrow\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-arrow-right\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/a\u003e\n        \u003ca href=\"#pp-dupes\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-coin\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003cspan class=\"lbl\"\u003eDupes\u003c\/span\u003e\u003csvg class=\"ico arrow\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-arrow-right\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/a\u003e\n        \u003ca href=\"#pp-faq\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-help\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003cspan class=\"lbl\"\u003eFAQ\u003c\/span\u003e\u003csvg class=\"ico arrow\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-arrow-right\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/a\u003e\n      \u003c\/div\u003e\n    \u003c\/nav\u003e\n    \n    \u003cdiv class=\"pp-scorecard\"\u003e\n      \u003cdiv class=\"item\"\u003e\n\u003cdiv class=\"lbl\"\u003ePregnancy\u003c\/div\u003e\n\u003cdiv class=\"val caution\"\u003e\n\u003csvg class=\"alert\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-info\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Caution\u003c\/div\u003e\n\u003c\/div\u003e\n      \u003cdiv class=\"item\"\u003e\n\u003cdiv class=\"lbl\"\u003eFungal Acne\u003c\/div\u003e\n\u003cdiv class=\"val safe\"\u003e\n\u003csvg class=\"check\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Yes\u003c\/div\u003e\n\u003c\/div\u003e\n      \u003cdiv class=\"item\"\u003e\n\u003cdiv class=\"lbl\"\u003eComedogenic\u003c\/div\u003e\n\u003cdiv class=\"val safe\"\u003e0\/5\u003c\/div\u003e\n\u003c\/div\u003e\n    \u003c\/div\u003e\n    \u003cdiv class=\"pp-specs\"\u003e\n\u003cdiv class=\"pp-spec\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-droplet\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv class=\"lbl\"\u003eType\u003c\/div\u003e\n\u003cdiv class=\"val\"\u003ePrescription Gel\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-spec\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-sparkle\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv class=\"lbl\"\u003eTarget\u003c\/div\u003e\n\u003cdiv class=\"val\"\u003eInflammatory Acne\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-spec\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-bottle\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv class=\"lbl\"\u003eSize\u003c\/div\u003e\n\u003cdiv class=\"val\"\u003e30g \/ 60g Tube\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-spec\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-sparkle\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv class=\"lbl\"\u003eFrequency\u003c\/div\u003e\n\u003cdiv class=\"val\"\u003eOnce Daily (PM)\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-spec\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-sparkle\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv class=\"lbl\"\u003eAge\u003c\/div\u003e\n\u003cdiv class=\"val\"\u003e12+ Years\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n    \n    \n    \u003cdiv class=\"pp-highlight\"\u003e\n      \u003cspan class=\"eyebrow\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-sparkle\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Why it's different\u003c\/span\u003e\n      \u003ch3\u003eAntibacterial Power\u003c\/h3\u003e\n      \u003cp\u003eClindamycin inhibits protein synthesis in C. acnes bacteria, reducing inflammation at the source of breakouts.\u003c\/p\u003e\n    \u003c\/div\u003e\n  \u003c\/section\u003e\n\n\n  \u003cmotion-element data-motion=\"fade-up\" data-motion-delay=\"50\"\u003e\u003cdiv class=\"pp-title\" id=\"pp-sensory\"\u003e\n\u003cspan class=\"eyebrow\"\u003e01\u003c\/span\u003e\u003ch2\u003eTexture \u0026amp; feel\u003c\/h2\u003e\n\u003cspan class=\"num\"\u003eSENSORY\u003c\/span\u003e\n\u003c\/div\u003e\u003c\/motion-element\u003e\n \n\u003cdiv class=\"pp-sensory\"\u003e\n\u003cdiv class=\"pp-sensory-item\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-droplet\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv class=\"label\"\u003eConsistency\u003c\/div\u003e\n\u003cdiv class=\"value\"\u003eAqueous Gel\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-sensory-item\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-wind\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv class=\"label\"\u003eScent\u003c\/div\u003e\n\u003cdiv class=\"value\"\u003eFragrance-Free\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-sensory-item\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-clock\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv class=\"label\"\u003eAbsorption\u003c\/div\u003e\n\u003cdiv class=\"value\"\u003e1–2 Minutes\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-sensory-item\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-target\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv class=\"label\"\u003eFinish\u003c\/div\u003e\n\u003cdiv class=\"value\"\u003eMatte \/ Slightly Drying\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"pp-features\"\u003e\n\u003cdiv class=\"pp-feature\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-flask\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003ch4\u003eAntibacterial Power\u003c\/h4\u003e\n\u003cp\u003eClindamycin inhibits protein synthesis in C. acnes bacteria, reducing inflammation at the source of breakouts.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-feature\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-flask\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003ch4\u003ePore-Clearing Oxidation\u003c\/h4\u003e\n\u003cp\u003eBenzoyl peroxide releases oxygen into pores, killing anaerobic bacteria and dissolving comedone-clogging debris.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-feature\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-shield-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003ch4\u003eResistance Prevention\u003c\/h4\u003e\n\u003cp\u003eThe benzoyl peroxide component prevents bacterial resistance to clindamycin — a key advantage over antibiotic-only formulas.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-feature\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-sparkle\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003ch4\u003eFast-Acting Relief\u003c\/h4\u003e\n\u003cp\u003eVisible reduction in inflammatory lesions in clinical trials within 2 weeks; significant clearing by week 11.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-feature\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-droplet\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003ch4\u003eLightweight Aqueous Base\u003c\/h4\u003e\n\u003cp\u003eWater-based gel formula absorbs without leaving heavy residue — gentler than oily ointments on acne-prone skin.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-feature\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-sparkle\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003ch4\u003eOnce-Daily Convenience\u003c\/h4\u003e\n\u003cp\u003eSingle evening application means better adherence and fewer chances of forgetting doses compared to twice-daily treatments.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cmotion-element data-motion=\"fade-up\" data-motion-delay=\"100\"\u003e\u003cdiv class=\"pp-title\" id=\"pp-safety\"\u003e\n\u003cspan class=\"eyebrow\"\u003e02\u003c\/span\u003e\u003ch2\u003eSafety \u0026amp; compatibility\u003c\/h2\u003e\n\u003cspan class=\"num\"\u003eSAFE\u003c\/span\u003e\n\u003c\/div\u003e\u003c\/motion-element\u003e\n \n\u003cdiv class=\"pp-safety\"\u003e\n\u003cdiv class=\"pp-safety-item caution\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-info\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cstrong\u003ePregnancy \u0026amp; Breastfeeding\u003c\/strong\u003e\n\u003cp\u003eUse only if benefit justifies risk. No adequate pregnancy data exists. If breastfeeding, do not apply to the breast area.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-safety-item safe\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cstrong\u003eFungal Acne (Malassezia) Safe\u003c\/strong\u003e\n\u003cp\u003eContains no fatty acids, esters, or polysorbates that feed Malassezia yeast. Generally safe for fungal acne.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-safety-item warning\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-x\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cstrong\u003eAvoid With Retinoids\u003c\/strong\u003e\n\u003cp\u003eDo not combine simultaneously with tretinoin, isotretinoin, or tazarotene — apply at different times of day.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-safety-item warning\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-x\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cstrong\u003eAvoid With Erythromycin\u003c\/strong\u003e\n\u003cp\u003eDo not use with topical or oral erythromycin-containing products due to potential antagonism.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-safety-item caution\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-sun\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cstrong\u003eSun Sensitivity\u003c\/strong\u003e\n\u003cp\u003eBenzoyl peroxide may increase sensitivity to sunlight. Daily SPF 30+ is essential during use.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-safety-item caution\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cstrong\u003eBleaches Fabric \u0026amp; Hair\u003c\/strong\u003e\n\u003cp\u003eWill bleach colored towels, pillowcases, and hair. Use white linens and wash hands thoroughly after applying.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-safety-item warning\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cstrong\u003eColitis Warning\u003c\/strong\u003e\n\u003cp\u003eDiscontinue and consult a doctor if severe, persistent diarrhea or abdominal cramps occur during use.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-safety-item info\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cstrong\u003eMaximum Use Duration\u003c\/strong\u003e\n\u003cp\u003eDo not use continuously beyond 12 weeks without medical review to prevent antibiotic resistance.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cmotion-element data-motion=\"fade-up\" data-motion-delay=\"150\"\u003e\u003cdiv class=\"pp-title\" id=\"pp-ingredients\"\u003e\n\u003cspan class=\"eyebrow\"\u003e03\u003c\/span\u003e\u003ch2\u003eIngredient breakdown\u003c\/h2\u003e\n\u003cspan class=\"num\"\u003eINGREDIENTS\u003c\/span\u003e\n\u003c\/div\u003e\u003c\/motion-element\u003e\n \n\u003cdiv class=\"pp-ingredient\" itemscope itemtype=\"https:\/\/schema.org\/ChemicalSubstance\"\u003e\n\u003cdiv class=\"ing-head\"\u003e\n\u003cdiv class=\"ing-icon\" aria-hidden=\"true\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-shield-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003ch3 itemprop=\"name\"\u003eClindamycin Phosphate 1%\u003cspan class=\"tag proven\"\u003eProven\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cp class=\"ing-desc\" itemprop=\"description\"\u003eA lincosamide antibiotic that binds to the 50S ribosomal subunit of Cutibacterium acnes (formerly P. acnes), inhibiting bacterial protein synthesis. It also reduces inflammatory mediators in the skin, calming red, painful pimples.\u003c\/p\u003e\n\u003cul class=\"pp-science\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eFDA-Approved:\u003c\/strong\u003e Listed by Stiefel Laboratories as the active antibiotic at 10 mg\/g (1% w\/w as clindamycin phosphate).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eClinical Evidence:\u003c\/strong\u003e In five randomized double-blind trials with 1,319 patients, the combination outperformed clindamycin alone, benzoyl peroxide alone, and vehicle for inflammatory lesions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMechanism:\u003c\/strong\u003e Targets gram-positive anaerobic bacteria responsible for inflammatory acne lesions.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cdiv class=\"pp-warning caution\"\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\" style=\"display:inline-block;width:14px;height:14px;vertical-align:middle\"\u003e\u003cuse href=\"#i-info\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\n\u003cdiv\u003eTopical absorption is low, but rare cases of pseudomembranous colitis have been reported. Discontinue if severe diarrhea occurs.\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"pp-ingredient\" itemscope itemtype=\"https:\/\/schema.org\/ChemicalSubstance\"\u003e\n\u003cdiv class=\"ing-head\"\u003e\n\u003cdiv class=\"ing-icon\" aria-hidden=\"true\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-flask\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003ch3 itemprop=\"name\"\u003eBenzoyl Peroxide 5%\u003cspan class=\"tag proven\"\u003eProven\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cp class=\"ing-desc\" itemprop=\"description\"\u003eA potent oxidizing agent that releases free-radical oxygen into the pore environment, killing anaerobic acne bacteria on contact. It also has mild keratolytic (exfoliating) effects, helping unclog pores and dissolve comedones.\u003c\/p\u003e\n\u003cul class=\"pp-science\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eAnti-Resistance:\u003c\/strong\u003e Adding benzoyl peroxide to clindamycin reduces the emergence of antibiotic-resistant bacteria — a major advantage over antibiotic monotherapy.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAbsorption Profile:\u003c\/strong\u003e Less than 2% enters systemic circulation as benzoic acid, which is rapidly excreted.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDual Action:\u003c\/strong\u003e Combines antibacterial activity with comedolytic and mild anti-inflammatory effects.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cdiv class=\"pp-warning caution\"\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\" style=\"display:inline-block;width:14px;height:14px;vertical-align:middle\"\u003e\u003cuse href=\"#i-info\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\n\u003cdiv\u003eInitial dryness, peeling, redness, and stinging are common in the first 1–2 weeks. Bleaches fabric and hair on contact.\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"pp-ingredient\" itemscope itemtype=\"https:\/\/schema.org\/ChemicalSubstance\"\u003e\n\u003cdiv class=\"ing-head\"\u003e\n\u003cdiv class=\"ing-icon\" aria-hidden=\"true\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-bottle\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003ch3 itemprop=\"name\"\u003eGlycerin ~5–10%\u003cspan class=\"tag proven\"\u003eProven\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cp class=\"ing-desc\" itemprop=\"description\"\u003eA humectant that draws water into the upper layers of the skin, helping offset the natural drying effect of benzoyl peroxide. It supports skin barrier hydration during the active treatment phase.\u003c\/p\u003e\n\u003cul class=\"pp-science\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eHydration Support:\u003c\/strong\u003e Reduces transepidermal water loss caused by benzoyl peroxide irritation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNon-Comedogenic:\u003c\/strong\u003e Rated 0 on the comedogenic scale — safe for acne-prone skin.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eVehicle Component:\u003c\/strong\u003e Listed as part of the aqueous gel base in the Stiefel formulation.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"pp-ingredient\" itemscope itemtype=\"https:\/\/schema.org\/ChemicalSubstance\"\u003e\n\u003cdiv class=\"ing-head\"\u003e\n\u003cdiv class=\"ing-icon\" aria-hidden=\"true\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-droplet\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003ch3 itemprop=\"name\"\u003eDimethicone ~2%\u003cspan class=\"tag proven\"\u003eProven\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cp class=\"ing-desc\" itemprop=\"description\"\u003eA skin-conditioning silicone that forms a breathable protective film on the skin's surface. It improves the gel's spreadability and reduces the perception of irritation while the actives work.\u003c\/p\u003e\n\u003cul class=\"pp-science\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eBarrier Support:\u003c\/strong\u003e Creates an occlusive layer that locks in moisture without clogging pores.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTexture Enhancer:\u003c\/strong\u003e Gives the aqueous gel a smoother, less sticky feel on application.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNon-Comedogenic:\u003c\/strong\u003e Considered safe for acne-prone skin at typical formulation levels.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"pp-ingredient\" itemscope itemtype=\"https:\/\/schema.org\/ChemicalSubstance\"\u003e\n\u003cdiv class=\"ing-head\"\u003e\n\u003cdiv class=\"ing-icon\" aria-hidden=\"true\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-flask\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003ch3 itemprop=\"name\"\u003eCarbomer ~0.5–1%\u003cspan class=\"tag proven\"\u003eProven\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cp class=\"ing-desc\" itemprop=\"description\"\u003eA high-molecular-weight acrylic acid polymer that gives the formula its smooth, non-sticky gel texture. Carbomer is inert and does not penetrate the skin.\u003c\/p\u003e\n\u003cul class=\"pp-science\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eGelling Agent:\u003c\/strong\u003e Carbomer 940 \/ homopolymer Type C is used as the structural backbone of the gel.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eInert \u0026amp; Safe:\u003c\/strong\u003e Has minimal skin penetration due to its large molecular size.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"pp-ingredient\" itemscope itemtype=\"https:\/\/schema.org\/ChemicalSubstance\"\u003e\n\u003cdiv class=\"ing-head\"\u003e\n\u003cdiv class=\"ing-icon\" aria-hidden=\"true\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-shield-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003ch3 itemprop=\"name\"\u003eDisodium EDTA \u0026amp;lt;0.5%\u003cspan class=\"tag proven\"\u003eProven\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cp class=\"ing-desc\" itemprop=\"description\"\u003eA chelating agent that binds trace metal ions in the formula, preventing oxidative degradation of the actives and maintaining stability of benzoyl peroxide and clindamycin during shelf life.\u003c\/p\u003e\n\u003cul class=\"pp-science\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eStability:\u003c\/strong\u003e Helps protect benzoyl peroxide from premature breakdown caused by metal contamination.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStandard Use:\u003c\/strong\u003e Used at very low concentrations across pharmaceutical and cosmetic formulations.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"pp-ingredient\" itemscope itemtype=\"https:\/\/schema.org\/ChemicalSubstance\"\u003e\n\u003cdiv class=\"ing-head\"\u003e\n\u003cdiv class=\"ing-icon\" aria-hidden=\"true\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-sparkle\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003ch3 itemprop=\"name\"\u003eDisodium Lauryl Sulfosuccinate \u0026amp;lt;1%\u003cspan class=\"tag supporting\"\u003ePromising\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cp class=\"ing-desc\" itemprop=\"description\"\u003eA mild surfactant and emulsifier that helps disperse the benzoyl peroxide particles evenly throughout the gel. Considered gentler than traditional sulfates.\u003c\/p\u003e\n\u003cul class=\"pp-science\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eEmulsification:\u003c\/strong\u003e Ensures uniform distribution of active ingredients in every dose.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMildness:\u003c\/strong\u003e Lower irritation profile than sodium lauryl sulfate (SLS).\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"pp-accordion\"\u003e\n\u003cinput type=\"checkbox\" id=\"pp-inci\"\u003e\n\u003clabel for=\"pp-inci\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\" style=\"display:inline-block;width:14px;height:14px;vertical-align:middle\"\u003e\u003cuse href=\"#i-list\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Full Ingredients (INCI)\u003c\/label\u003e\n\u003cdiv class=\"pp-acc-content\"\u003e\n\u003cp\u003e\u003cstrong\u003e11 ingredients\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eClindamycin Phosphate (1%), Benzoyl Peroxide (5%), Carbomer, Dimethicone, Disodium Lauryl Sulfosuccinate, Disodium EDTA, Glycerin, Silica, Poloxamer 182, Water (Purified), Sodium Hydroxide.\u003c\/p\u003e\n\u003cdiv class=\"free-list\"\u003e\n\u003cstrong\u003eFREE FROM:\u003c\/strong\u003e Fragrance\/parfum, essential oils, alcohol denat., sulfates (SLS\/SLES), parabens (most current EU formulations), mineral oil, lanolin, retinoids, salicylic acid, AHA\/BHA, hydroquinone, chemical sunscreens, fatty alcohols, esters, polysorbates, animal-derived ingredients.\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cmotion-element data-motion=\"fade-up\" data-motion-delay=\"200\"\u003e\u003cdiv class=\"pp-title\" id=\"pp-routine\"\u003e\n\u003cspan class=\"eyebrow\"\u003e04\u003c\/span\u003e\u003ch2\u003eWhere it fits in your routine\u003c\/h2\u003e\n\u003cspan class=\"num\"\u003eROUTINE\u003c\/span\u003e\n\u003c\/div\u003e\u003c\/motion-element\u003e\n \n\u003cdiv class=\"pp-routine\"\u003e\n\u003cdiv class=\"pp-routine-step\"\u003e\n\u003cdiv class=\"num\"\u003e1\u003c\/div\u003e\n\u003cdiv class=\"name\"\u003eGentle Cleanser\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-routine-step\"\u003e\n\u003cdiv class=\"num\"\u003e2\u003c\/div\u003e\n\u003cdiv class=\"name\"\u003ePat Dry (10–20 min)\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-routine-step current\"\u003e\n\u003cdiv class=\"num\"\u003e3\u003c\/div\u003e\n\u003cdiv class=\"name\"\u003eDuac Gel (PM)\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-routine-step\"\u003e\n\u003cdiv class=\"num\"\u003e4\u003c\/div\u003e\n\u003cdiv class=\"name\"\u003eWait 5 min\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-routine-step\"\u003e\n\u003cdiv class=\"num\"\u003e5\u003c\/div\u003e\n\u003cdiv class=\"name\"\u003eMoisturizer\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-routine-step\"\u003e\n\u003cdiv class=\"num\"\u003e6\u003c\/div\u003e\n\u003cdiv class=\"name\"\u003eSPF (AM)\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n \n\u003cp style=\"text-align:center;color:var(--pp-text-muted);font-size:0.82em;margin-top:12px\"\u003ePro tip: Apply Duac to dry skin only — the SPC recommends washing the face, then waiting 10–20 minutes before applying the gel to reduce stinging.\n\u003c\/p\u003e\n\n\u003cmotion-element data-motion=\"fade-up\" data-motion-delay=\"0\"\u003e\u003cdiv class=\"pp-title\" id=\"pp-how-to-use\"\u003e\n\u003cspan class=\"eyebrow\"\u003e05\u003c\/span\u003e\u003ch2\u003eHow to use\u003c\/h2\u003e\n\u003cspan class=\"num\"\u003eHOW TO USE\u003c\/span\u003e\n\u003c\/div\u003e\u003c\/motion-element\u003e\n \n\u003cdiv class=\"pp-steps\"\u003e\n\u003cdiv class=\"pp-step\"\u003e\n\u003cdiv class=\"num\"\u003e1\u003c\/div\u003e\n\u003cdiv\u003e\n\u003ch4\u003eCleanse Gently\u003c\/h4\u003e\n\u003cp\u003eWash the affected area with a mild, fragrance-free cleanser. Rinse with warm water and pat (not rub) skin dry.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-step\"\u003e\n\u003cdiv class=\"num\"\u003e2\u003c\/div\u003e\n\u003cdiv\u003e\n\u003ch4\u003eWait 10–20 Minutes\u003c\/h4\u003e\n\u003cp\u003eLet skin fully dry before application — applying to damp skin significantly increases stinging and irritation risk.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-step\"\u003e\n\u003cdiv class=\"num\"\u003e3\u003c\/div\u003e\n\u003cdiv\u003e\n\u003ch4\u003eApply a Pea-Sized Amount\u003c\/h4\u003e\n\u003cp\u003eUse a fingertip-length of gel for the entire face. Apply once daily in the evening to all acne-prone areas, not just spots.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-step\"\u003e\n\u003cdiv class=\"num\"\u003e4\u003c\/div\u003e\n\u003cdiv\u003e\n\u003ch4\u003eSpread a Thin Layer\u003c\/h4\u003e\n\u003cp\u003eIf the gel doesn't rub in easily, you're using too much. Avoid eyes, lips, nostrils, and mucous membranes.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-step\"\u003e\n\u003cdiv class=\"num\"\u003e5\u003c\/div\u003e\n\u003cdiv\u003e\n\u003ch4\u003eWash Hands Thoroughly\u003c\/h4\u003e\n\u003cp\u003eBenzoyl peroxide will bleach hair and fabrics on contact — wash hands and avoid touching colored materials.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-step\"\u003e\n\u003cdiv class=\"num\"\u003e6\u003c\/div\u003e\n\u003cdiv\u003e\n\u003ch4\u003eFollow With Moisturizer\u003c\/h4\u003e\n\u003cp\u003eWait 5 minutes, then apply a non-comedogenic, fragrance-free moisturizer to offset dryness and protect the barrier.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-step\"\u003e\n\u003cdiv class=\"num\"\u003e7\u003c\/div\u003e\n\u003cdiv\u003e\n\u003ch4\u003eDaily Sunscreen (AM)\u003c\/h4\u003e\n\u003cp\u003eApply broad-spectrum SPF 30+ every morning. Benzoyl peroxide increases UV sensitivity and risk of irritation.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cmotion-element data-motion=\"fade-up\" data-motion-delay=\"50\"\u003e\u003cdiv class=\"pp-title\" id=\"pp-who-is-it-for\"\u003e\n\u003cspan class=\"eyebrow\"\u003e06\u003c\/span\u003e\u003ch2\u003eWho is it for?\u003c\/h2\u003e\n\u003cspan class=\"num\"\u003eWHO\u003c\/span\u003e\n\u003c\/div\u003e\u003c\/motion-element\u003e\n \n\u003cdiv class=\"pp-fit\"\u003e\n\u003cdiv class=\"pp-fit-box yes\"\u003e\n\u003ch4\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003ePerfect for you if:\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003csvg class=\"ico check\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e You have mild to moderate inflammatory acne (red, painful pimples and pustules)\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico check\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e You are aged 12 or older with acne vulgaris\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico check\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e OTC benzoyl peroxide alone hasn't fully cleared your skin\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico check\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e You prefer a once-daily evening routine over multiple-step regimens\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico check\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e You have oily or combination skin that tolerates active ingredients\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico check\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e You are looking for a non-retinoid acne treatment\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-fit-box no\"\u003e\n\u003ch4\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-x\"\u003e\u003c\/use\u003e\u003c\/svg\u003eConsider alternatives if:\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003csvg class=\"ico x\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-x\"\u003e\u003c\/use\u003e\u003c\/svg\u003e You are pregnant or breastfeeding (consult your physician first)\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico x\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-x\"\u003e\u003c\/use\u003e\u003c\/svg\u003e You have a history of regional enteritis, ulcerative colitis, or pseudomembranous colitis\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico x\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-x\"\u003e\u003c\/use\u003e\u003c\/svg\u003e You have very sensitive, eczema-prone, or rosacea skin\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico x\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-x\"\u003e\u003c\/use\u003e\u003c\/svg\u003e You are allergic to clindamycin, lincomycin, or benzoyl peroxide\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico x\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-x\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Your acne is mostly non-inflammatory (blackheads\/whiteheads only) — a retinoid may work better\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico x\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-x\"\u003e\u003c\/use\u003e\u003c\/svg\u003e You have severe nodulocystic acne (oral therapy may be required)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cmotion-element data-motion=\"fade-up\" data-motion-delay=\"100\"\u003e\u003cdiv class=\"pp-title\" id=\"pp-skin-types\"\u003e\n\u003cspan class=\"eyebrow\"\u003e07\u003c\/span\u003e\u003ch2\u003eSkin type compatibility\u003c\/h2\u003e\n\u003cspan class=\"num\"\u003eSKIN TYPES\u003c\/span\u003e\n\u003c\/div\u003e\u003c\/motion-element\u003e\n \n\u003cdiv class=\"pp-skin-grid\"\u003e\n\u003cdiv class=\"pp-skin-card\"\u003e\n\u003cdiv class=\"row\"\u003e\n\u003cdiv class=\"type\"\u003eOily Skin\u003c\/div\u003e\n\u003cspan class=\"rate excellent\"\u003eExcellent\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"meter tier-good\"\u003e\n\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cp class=\"note\"\u003eAqueous gel formula won't add oil; benzoyl peroxide reduces sebum-related breakouts effectively.\u003c\/p\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"pp-skin-card\"\u003e\n\u003cdiv class=\"row\"\u003e\n\u003cdiv class=\"type\"\u003eDry Skin\u003c\/div\u003e\n\u003cspan class=\"rate moderate\"\u003eModerate\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"meter tier-good\"\u003e\n\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan\u003e\u003c\/span\u003e\u003cspan\u003e\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cp class=\"note\"\u003eExpect dryness and peeling, especially in weeks 1–2. Pair with a rich, fragrance-free moisturizer.\u003c\/p\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"pp-skin-card\"\u003e\n\u003cdiv class=\"row\"\u003e\n\u003cdiv class=\"type\"\u003eCombination\u003c\/div\u003e\n\u003cspan class=\"rate excellent\"\u003eExcellent\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"meter tier-good\"\u003e\n\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cp class=\"note\"\u003eTargets oily T-zone acne while glycerin and dimethicone offer some hydration to drier areas.\u003c\/p\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"pp-skin-card\"\u003e\n\u003cdiv class=\"row\"\u003e\n\u003cdiv class=\"type\"\u003eSensitive\u003c\/div\u003e\n\u003cspan class=\"rate poor\"\u003eUse With Caution\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"meter tier-moderate\"\u003e\n\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan\u003e\u003c\/span\u003e\u003cspan\u003e\u003c\/span\u003e\u003cspan\u003e\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cp class=\"note\"\u003e5% benzoyl peroxide can cause significant erythema, burning, and peeling. Patch test first; consider lower-strength alternatives.\u003c\/p\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"pp-skin-card\"\u003e\n\u003cdiv class=\"row\"\u003e\n\u003cdiv class=\"type\"\u003eAcne-Prone\u003c\/div\u003e\n\u003cspan class=\"rate excellent\"\u003eExcellent\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"meter tier-good\"\u003e\n\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cp class=\"note\"\u003eSpecifically formulated for inflammatory acne vulgaris — the gold-standard prescription combination.\u003c\/p\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"pp-skin-card\"\u003e\n\u003cdiv class=\"row\"\u003e\n\u003cdiv class=\"type\"\u003eMature Skin\u003c\/div\u003e\n\u003cspan class=\"rate good\"\u003eGood\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"meter tier-good\"\u003e\n\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan\u003e\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cp class=\"note\"\u003eEffective for adult hormonal acne but the drying effect may emphasize fine lines — moisturize generously.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cmotion-element data-motion=\"fade-up\" data-motion-delay=\"150\"\u003e\u003cdiv class=\"pp-title\" id=\"pp-results\"\u003e\n\u003cspan class=\"eyebrow\"\u003e08\u003c\/span\u003e\u003ch2\u003eResults timeline\u003c\/h2\u003e\n\u003cspan class=\"num\"\u003eWEEK 12+\u003c\/span\u003e\n\u003c\/div\u003e\u003c\/motion-element\u003e\n \n\u003cdiv class=\"pp-timeline\"\u003e\n\u003cdiv class=\"pp-tl-item\"\u003e\n\u003cspan class=\"time\"\u003eDays 1–7\u003c\/span\u003e\n\u003ch4\u003eAdjustment Phase\u003c\/h4\u003e\n\u003cp\u003eInitial dryness, mild redness, peeling, and possible stinging are common. Some users report a brief purge of underlying clogs. Inflammatory pimples may begin calming.\u003c\/p\u003e\n\u003cspan class=\"percent\"\u003e~70% experience initial dryness\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-tl-item\"\u003e\n\u003cspan class=\"time\"\u003eWeeks 2–3\u003c\/span\u003e\n\u003ch4\u003eVisible Improvement\u003c\/h4\u003e\n\u003cp\u003eSkin acclimates; redness and peeling typically decrease. Active inflammatory pimples become noticeably smaller and less painful. Many users see fewer new breakouts emerging.\u003c\/p\u003e\n\u003cspan class=\"percent\"\u003e~60% notice clearer skin\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-tl-item\"\u003e\n\u003cspan class=\"time\"\u003eWeeks 4–6\u003c\/span\u003e\n\u003ch4\u003eSignificant Clearance\u003c\/h4\u003e\n\u003cp\u003eMajor reduction in inflammatory lesions. The Stiefel patient leaflet states it may take 2–5 weeks to see full effect. Skin tone evens out as post-inflammatory marks begin fading.\u003c\/p\u003e\n\u003cspan class=\"percent\"\u003e~75% see major improvement\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-tl-item\"\u003e\n\u003cspan class=\"time\"\u003eWeeks 8–11\u003c\/span\u003e\n\u003ch4\u003ePeak Efficacy\u003c\/h4\u003e\n\u003cp\u003ePhase 3 trials measured primary endpoint at week 11. Greatest reduction in inflammatory lesion counts achieved, with significant clearance versus monotherapy or vehicle.\u003c\/p\u003e\n\u003cspan class=\"percent\"\u003e~80% report clear or almost-clear skin\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-tl-item\"\u003e\n\u003cspan class=\"time\"\u003eWeek 12+\u003c\/span\u003e\n\u003ch4\u003eMedical Review Required\u003c\/h4\u003e\n\u003cp\u003eContinuous use beyond 12 weeks should be reviewed by a physician to prevent antibiotic resistance. Many switch to maintenance therapy with a retinoid or BPO-only product.\u003c\/p\u003e\n\u003cspan class=\"percent\"\u003e100% require medical follow-up\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cmotion-element data-motion=\"fade-up\" data-motion-delay=\"200\"\u003e\u003cdiv class=\"pp-title\" id=\"pp-reviews\"\u003e\n\u003cspan class=\"eyebrow\"\u003e09\u003c\/span\u003e\u003ch2\u003eRatings by platform\u003c\/h2\u003e\n\u003cspan class=\"num\"\u003e2K+ REVIEWS\u003c\/span\u003e\n\u003c\/div\u003e\u003c\/motion-element\u003e\n \n\u003cdiv class=\"pp-reviews\"\u003e\n\u003cdiv class=\"pp-review-card\"\u003e\n\u003cdiv class=\"platform\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-shield-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003eDrugs.com\u003c\/div\u003e\n\u003cdiv class=\"stats\"\u003e\n\u003cdiv class=\"stat\"\u003e\n\u003cdiv class=\"num\"\u003e\n\u003cdiv class=\"meter\"\u003e\n\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\n\u003c\/div\u003e 7.6\/10\u003c\/div\u003e\n\u003cdiv class=\"lbl\"\u003eRating\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"stat\"\u003e\n\u003cdiv class=\"num\"\u003e200+\u003c\/div\u003e\n\u003cdiv class=\"lbl\"\u003eReviews\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"complaint\"\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\" style=\"display:inline-block;width:14px;height:14px;vertical-align:middle\"\u003e\u003cuse href=\"#i-info\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Main complaint: Initial dryness, peeling, and burning sensation in the first 1–2 weeks.\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"pp-review-card\"\u003e\n\u003cdiv class=\"platform\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-shield-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003eWebMD\u003c\/div\u003e\n\u003cdiv class=\"stats\"\u003e\n\u003cdiv class=\"stat\"\u003e\n\u003cdiv class=\"num\"\u003e\n\u003cdiv class=\"meter\"\u003e\n\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\n\u003c\/div\u003e 3.7\/5\u003c\/div\u003e\n\u003cdiv class=\"lbl\"\u003eRating\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"stat\"\u003e\n\u003cdiv class=\"num\"\u003e100+\u003c\/div\u003e\n\u003cdiv class=\"lbl\"\u003eReviews\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"complaint\"\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\" style=\"display:inline-block;width:14px;height:14px;vertical-align:middle\"\u003e\u003cuse href=\"#i-info\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Main complaint: Acne returns when use is discontinued; some report skin thinning with long-term use.\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"pp-review-card\"\u003e\n\u003cdiv class=\"platform\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-sparkle\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003eAcne.org\u003c\/div\u003e\n\u003cdiv class=\"stats\"\u003e\n\u003cdiv class=\"stat\"\u003e\n\u003cdiv class=\"num\"\u003e\n\u003cdiv class=\"meter\"\u003e\n\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\n\u003c\/div\u003e 3.8\/5\u003c\/div\u003e\n\u003cdiv class=\"lbl\"\u003eRating\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"stat\"\u003e\n\u003cdiv class=\"num\"\u003e1,547\u003c\/div\u003e\n\u003cdiv class=\"lbl\"\u003eReviews\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"complaint\"\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\" style=\"display:inline-block;width:14px;height:14px;vertical-align:middle\"\u003e\u003cuse href=\"#i-info\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Main complaint: Bleaches towels and pillowcases; takes 3–4 weeks to see improvement.\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"pp-review-card\"\u003e\n\u003cdiv class=\"platform\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-sparkle\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003eThe Independent Pharmacy (UK)\u003c\/div\u003e\n\u003cdiv class=\"stats\"\u003e\n\u003cdiv class=\"stat\"\u003e\n\u003cdiv class=\"num\"\u003e\n\u003cdiv class=\"meter\"\u003e\n\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\u003cspan class=\"on\"\u003e\u003c\/span\u003e\n\u003c\/div\u003e 4.7\/5\u003c\/div\u003e\n\u003cdiv class=\"lbl\"\u003eRating\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"stat\"\u003e\n\u003cdiv class=\"num\"\u003e500+\u003c\/div\u003e\n\u003cdiv class=\"lbl\"\u003eReviews\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"complaint\"\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\" style=\"display:inline-block;width:14px;height:14px;vertical-align:middle\"\u003e\u003cuse href=\"#i-info\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Main complaint: Requires consistent nightly use; price point higher than OTC alternatives.\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cmotion-element data-motion=\"fade-up\" data-motion-delay=\"0\"\u003e\u003cdiv class=\"pp-title\" id=\"pp-pros-cons\"\u003e\n\u003cspan class=\"eyebrow\"\u003e10\u003c\/span\u003e\u003ch2\u003ePros \u0026amp; cons\u003c\/h2\u003e\n\u003cspan class=\"num\"\u003eBALANCED\u003c\/span\u003e\n\u003c\/div\u003e\u003c\/motion-element\u003e\n \n\u003cdiv class=\"pp-proscons\"\u003e\n\u003cdiv class=\"pp-pc pros\"\u003e\n\u003ch4\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003ePraised\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Visibly clearer skin in 2–5 weeks for most users\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Dual-action: kills bacteria + unclogs pores in one product\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Once-daily application improves compliance\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Prevents antibiotic resistance better than clindamycin alone\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Backed by five published Phase 3 clinical trials\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Lightweight aqueous gel — not greasy or thick\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Effective for hormonal and adult acne\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Fragrance-free formulation\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-pc cons\"\u003e\n\u003ch4\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-x\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003eCriticized\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-x\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Significant dryness and peeling in the first 1–2 weeks\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-x\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Bleaches colored fabric, towels, pillowcases, and hair\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-x\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Increases sun sensitivity — daily SPF mandatory\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-x\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Maximum 12-week course; not for indefinite use\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-x\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Acne can return when treatment is stopped\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-x\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Prescription required in most countries (UK, EU, US)\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-x\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Risk of bacterial resistance with prolonged use\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-x\"\u003e\u003c\/use\u003e\u003c\/svg\u003e Not suitable for very sensitive or rosacea-prone skin\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cmotion-element data-motion=\"fade-up\" data-motion-delay=\"50\"\u003e\u003cdiv class=\"pp-title\" id=\"pp-dupes\"\u003e\n\u003cspan class=\"eyebrow\"\u003e11\u003c\/span\u003e\u003ch2\u003eBudget-friendly alternatives (dupes)\u003c\/h2\u003e\n\u003cspan class=\"num\"\u003eDUPES\u003c\/span\u003e\n\u003c\/div\u003e\u003c\/motion-element\u003e\n \n\u003cdiv class=\"pp-dupes\"\u003e\n\u003cdiv class=\"pp-dupe-card\"\u003e\n\u003cspan class=\"match high\"\u003e95% Match\u003c\/span\u003e\u003cdiv class=\"photo\"\u003e\u003ca href=\"https:\/\/www.skincarisma.com\/products\/clindamycin-and-benzoyl-peroxide-gel-1-5\" target=\"_blank\" rel=\"noopener\" style=\"display:block;width:100%;height:100%\"\u003e\u003cimg class=\"pp-product-photo\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0907\/5028\/8215\/files\/492v7xrd29s99wit964b0er1n5ra.jpg?v=1767016710\" alt=\"Clindamycin and Benzoyl Peroxide Gel 1%\/5%\" loading=\"lazy\" width=\"200\" height=\"200\" style=\"display:block;width:100%;height:100%;object-fit:cover\"\u003e\u003c\/a\u003e\u003c\/div\u003e\n\u003cdiv class=\"body\"\u003e\n\u003cdiv class=\"name\"\u003e\u003ca href=\"https:\/\/www.skincarisma.com\/products\/clindamycin-and-benzoyl-peroxide-gel-1-5\" target=\"_blank\" rel=\"noopener\" style=\"color:inherit;text-decoration:none\"\u003eGeneric Clindamycin 1% \/ Benzoyl Peroxide 5% Gel\u003c\/a\u003e\u003c\/div\u003e\n\u003cdiv class=\"price-row\"\u003e\n\u003cdiv class=\"amount\"\u003e$25–$50\u003c\/div\u003e\n\u003cdiv class=\"tag budget\"\u003eBudget Pick\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp class=\"diff\"\u003eThe pharmacological equivalent — same actives, same concentrations, same FDA approval. Different inactive ingredients may slightly alter texture but clinical efficacy is identical. Available with discount coupons.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"pp-dupe-card\"\u003e\n\u003cspan class=\"match high\"\u003e90% Match\u003c\/span\u003e\u003cdiv class=\"photo\"\u003e\u003cdiv class=\"photo-fallback\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-bottle\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv class=\"body\"\u003e\n\u003cdiv class=\"name\"\u003eBenzaClin (Clindamycin 1% \/ BPO 5%)\u003c\/div\u003e\n\u003cdiv class=\"price-row\"\u003e\n\u003cdiv class=\"amount\"\u003e$60–$120\u003c\/div\u003e\n\u003cdiv class=\"tag similar\"\u003eSister Brand\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp class=\"diff\"\u003eSame active ingredients at the same strengths as Duac. The base formulation differs slightly but real-world results are comparable. Often the prescribed alternative in the US market.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"pp-dupe-card\"\u003e\n\u003cspan class=\"match medium\"\u003e75% Match\u003c\/span\u003e\u003cdiv class=\"photo\"\u003e\u003cdiv class=\"photo-fallback\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-bottle\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv class=\"body\"\u003e\n\u003cdiv class=\"name\"\u003eAcanya Gel (Clindamycin 1.2% \/ BPO 2.5%)\u003c\/div\u003e\n\u003cdiv class=\"price-row\"\u003e\n\u003cdiv class=\"amount\"\u003e$80–$150\u003c\/div\u003e\n\u003cdiv class=\"tag similar\"\u003eGentler Option\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp class=\"diff\"\u003eLower benzoyl peroxide concentration (2.5% vs 5%) means significantly less irritation, dryness, and peeling — at a small cost to potency. Better for sensitive skin starting out.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"pp-dupe-card\"\u003e\n\u003cspan class=\"match medium\"\u003e70% Match\u003c\/span\u003e\u003cdiv class=\"photo\"\u003e\u003cdiv class=\"photo-fallback\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-bottle\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv class=\"body\"\u003e\n\u003cdiv class=\"name\"\u003eOnexton (Clindamycin 1.2% \/ BPO 3.75%)\u003c\/div\u003e\n\u003cdiv class=\"price-row\"\u003e\n\u003cdiv class=\"amount\"\u003e$70–$140\u003c\/div\u003e\n\u003cdiv class=\"tag similar\"\u003eMid-Strength\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp class=\"diff\"\u003eMiddle-ground BPO concentration sits between Acanya and Duac. Balances efficacy and tolerability. Same once-daily application schedule.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"pp-dupe-card\"\u003e\n\u003cspan class=\"match medium\"\u003e65% Match\u003c\/span\u003e\u003cdiv class=\"photo\"\u003e\u003cdiv class=\"photo-fallback\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-bottle\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv class=\"body\"\u003e\n\u003cdiv class=\"name\"\u003ePanOxyl 4% Acne Foaming Wash + Clindamycin Solution\u003c\/div\u003e\n\u003cdiv class=\"price-row\"\u003e\n\u003cdiv class=\"amount\"\u003e$15–$40\u003c\/div\u003e\n\u003cdiv class=\"tag budget\"\u003eDIY Stack\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp class=\"diff\"\u003eOTC benzoyl peroxide wash combined with prescription clindamycin solution mimics the dual-action approach. Less convenient (two steps), but significantly cheaper if your insurance won't cover Duac.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"pp-dupe-card\"\u003e\n\u003cspan class=\"match low\"\u003e55% Match\u003c\/span\u003e\u003cdiv class=\"photo\"\u003e\u003ca href=\"https:\/\/www.skincarisma.com\/products\/adapalene-gel-0-4\" target=\"_blank\" rel=\"noopener\" style=\"display:block;width:100%;height:100%\"\u003e\u003cimg class=\"pp-product-photo\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0907\/5028\/8215\/files\/ej9756kxs6kxq05n0gylazqmvnh4_square_1ee2130f-844d-4aef-b967-cc76168634de.png?v=1776769397\" alt=\"Adapalene Gel 0.1%\" loading=\"lazy\" width=\"200\" height=\"200\" style=\"display:block;width:100%;height:100%;object-fit:cover\"\u003e\u003c\/a\u003e\u003c\/div\u003e\n\u003cdiv class=\"body\"\u003e\n\u003cdiv class=\"name\"\u003e\u003ca href=\"https:\/\/www.skincarisma.com\/products\/adapalene-gel-0-4\" target=\"_blank\" rel=\"noopener\" style=\"color:inherit;text-decoration:none\"\u003eDifferin Gel 0.1% (OTC Adapalene)\u003c\/a\u003e\u003c\/div\u003e\n\u003cdiv class=\"price-row\"\u003e\n\u003cdiv class=\"amount\"\u003e$12–$15\u003c\/div\u003e\n\u003cdiv class=\"tag budget\"\u003eOTC Option\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp class=\"diff\"\u003eDifferent mechanism — a topical retinoid rather than antibiotic. Excellent for non-inflammatory acne (blackheads\/whiteheads) and long-term maintenance. Less effective for actively inflamed pimples.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cmotion-element data-motion=\"fade-up\" data-motion-delay=\"100\"\u003e\u003cdiv class=\"pp-title\" id=\"pp-compare\"\u003e\n\u003cspan class=\"eyebrow\"\u003e12\u003c\/span\u003e\u003ch2\u003eComparison with competitors\u003c\/h2\u003e\n\u003cspan class=\"num\"\u003eSIDE-BY-SIDE\u003c\/span\u003e\n\u003c\/div\u003e\u003c\/motion-element\u003e\n \n\u003cdiv class=\"pp-compare\"\u003e\n\u003cdiv class=\"pp-compare-card featured\"\u003e\n\u003cdiv class=\"photo\"\u003e\u003cdiv class=\"placeholder\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\" style=\"width:36px;height:36px;color:var(--pp-ink-3)\"\u003e\u003cuse href=\"#i-bottle\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv class=\"head\"\u003e\n\u003ch4\u003eDuac Once Daily Gel\u003c\/h4\u003e\n\u003cdiv class=\"price\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"body\"\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eActive Ingredients\u003c\/span\u003e\n\u003cspan class=\"value good\"\u003eClindamycin 1% + BPO 5%\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eMechanism\u003c\/span\u003e\n\u003cspan class=\"value\"\u003eAntibiotic + Oxidizer\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eBest For\u003c\/span\u003e\n\u003cspan class=\"value good\"\u003eInflammatory Acne\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eFrequency\u003c\/span\u003e\n\u003cspan class=\"value good\"\u003eOnce Daily (PM)\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eTime to Results\u003c\/span\u003e\n\u003cspan class=\"value good\"\u003e2–5 Weeks\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eMax Duration\u003c\/span\u003e\n\u003cspan class=\"value bad\"\u003e12 Weeks\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003ePregnancy\u003c\/span\u003e\n\u003cspan class=\"value bad\"\u003eCaution\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-card\"\u003e\n\u003cdiv class=\"photo\"\u003e\u003ca href=\"https:\/\/www.skincarisma.com\/products\/epiduo-forte-gel\" target=\"_blank\" rel=\"noopener\" style=\"display:block;width:100%;height:100%\"\u003e\u003cimg class=\"pp-product-photo\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0907\/5028\/8215\/files\/cqlrln7qe0khc1mz5fq5g5o4p082.jpg?v=1774355407\" alt=\"Epiduo Forte Gel\" loading=\"lazy\" width=\"200\" height=\"200\" style=\"display:block;width:100%;height:100%;object-fit:cover\"\u003e\u003c\/a\u003e\u003c\/div\u003e\n\u003cdiv class=\"head\"\u003e\n\u003ca href=\"https:\/\/www.skincarisma.com\/products\/epiduo-forte-gel\" target=\"_blank\" rel=\"noopener\" style=\"color:inherit;text-decoration:none\"\u003e\u003ch4\u003eEpiduo \/ Epiduo Forte (Galderma)\u003c\/h4\u003e\u003c\/a\u003e\u003cdiv class=\"price\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"body\"\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eActive Ingredients\u003c\/span\u003e\n\u003cspan class=\"value\"\u003eAdapalene 0.1–0.3% + BPO 2.5%\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eMechanism\u003c\/span\u003e\n\u003cspan class=\"value\"\u003eRetinoid + Oxidizer\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eBest For\u003c\/span\u003e\n\u003cspan class=\"value\"\u003eMixed Comedonal + Inflammatory\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eFrequency\u003c\/span\u003e\n\u003cspan class=\"value good\"\u003eOnce Daily (PM)\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eTime to Results\u003c\/span\u003e\n\u003cspan class=\"value neutral\"\u003e4–8 Weeks\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eMax Duration\u003c\/span\u003e\n\u003cspan class=\"value good\"\u003eLong-term OK\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003ePregnancy\u003c\/span\u003e\n\u003cspan class=\"value bad\"\u003eContraindicated\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-card\"\u003e\n\u003cdiv class=\"photo\"\u003e\u003cdiv class=\"placeholder\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\" style=\"width:36px;height:36px;color:var(--pp-ink-3)\"\u003e\u003cuse href=\"#i-bottle\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv class=\"head\"\u003e\n\u003ch4\u003eTreclin \/ Acnatac (Clindamycin + Tretinoin)\u003c\/h4\u003e\n\u003cdiv class=\"price\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"body\"\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eActive Ingredients\u003c\/span\u003e\n\u003cspan class=\"value\"\u003eClindamycin 1% + Tretinoin 0.025%\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eMechanism\u003c\/span\u003e\n\u003cspan class=\"value\"\u003eAntibiotic + Retinoid\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eBest For\u003c\/span\u003e\n\u003cspan class=\"value\"\u003eMixed Acne with Texture Issues\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eFrequency\u003c\/span\u003e\n\u003cspan class=\"value good\"\u003eOnce Daily (PM)\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eTime to Results\u003c\/span\u003e\n\u003cspan class=\"value neutral\"\u003e4–12 Weeks\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eMax Duration\u003c\/span\u003e\n\u003cspan class=\"value bad\"\u003e12 Weeks (antibiotic)\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003ePregnancy\u003c\/span\u003e\n\u003cspan class=\"value bad\"\u003eContraindicated\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-card\"\u003e\n\u003cdiv class=\"photo\"\u003e\u003ca href=\"https:\/\/www.skincarisma.com\/products\/adapalene-gel-0-4\" target=\"_blank\" rel=\"noopener\" style=\"display:block;width:100%;height:100%\"\u003e\u003cimg class=\"pp-product-photo\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0907\/5028\/8215\/files\/ej9756kxs6kxq05n0gylazqmvnh4_square_1ee2130f-844d-4aef-b967-cc76168634de.png?v=1776769397\" alt=\"Adapalene Gel 0.1%\" loading=\"lazy\" width=\"200\" height=\"200\" style=\"display:block;width:100%;height:100%;object-fit:cover\"\u003e\u003c\/a\u003e\u003c\/div\u003e\n\u003cdiv class=\"head\"\u003e\n\u003ca href=\"https:\/\/www.skincarisma.com\/products\/adapalene-gel-0-4\" target=\"_blank\" rel=\"noopener\" style=\"color:inherit;text-decoration:none\"\u003e\u003ch4\u003eDifferin Gel (OTC Adapalene 0.1%)\u003c\/h4\u003e\u003c\/a\u003e\u003cdiv class=\"price\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"body\"\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eActive Ingredients\u003c\/span\u003e\n\u003cspan class=\"value\"\u003eAdapalene 0.1%\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eMechanism\u003c\/span\u003e\n\u003cspan class=\"value\"\u003eRetinoid only\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eBest For\u003c\/span\u003e\n\u003cspan class=\"value\"\u003eComedones, Maintenance\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eFrequency\u003c\/span\u003e\n\u003cspan class=\"value good\"\u003eOnce Daily (PM)\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eTime to Results\u003c\/span\u003e\n\u003cspan class=\"value bad\"\u003e8–12 Weeks\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003eMax Duration\u003c\/span\u003e\n\u003cspan class=\"value good\"\u003eIndefinite\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-compare-row\"\u003e\n\u003cspan class=\"label\"\u003ePregnancy\u003c\/span\u003e\n\u003cspan class=\"value bad\"\u003eAvoid\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cmotion-element data-motion=\"fade-up\" data-motion-delay=\"150\"\u003e\u003cdiv class=\"pp-title\" id=\"pp-storage\"\u003e\n\u003cspan class=\"eyebrow\"\u003e13\u003c\/span\u003e\u003ch2\u003eStorage \u0026amp; shelf life\u003c\/h2\u003e\n\u003cspan class=\"num\"\u003e2 MONTHS\u003c\/span\u003e\n\u003c\/div\u003e\u003c\/motion-element\u003e\n \n\u003cdiv class=\"pp-safety\"\u003e\n\u003cdiv class=\"pp-safety-item info\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-clock\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cstrong\u003ePeriod After Opening (PAO)\u003c\/strong\u003e\n\u003cp\u003e2 months after dispensing at room temperature. Discard any unused product after 60 days.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-safety-item info\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-shield-check\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cstrong\u003eStorage\u003c\/strong\u003e\n\u003cp\u003eStore at room temperature up to 25°C (77°F). Do not freeze. Pre-dispensing, refrigerate at 2–8°C.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-safety-item info\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-bottle\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cstrong\u003ePackaging\u003c\/strong\u003e\n\u003cp\u003eAluminum tube with screw cap, supplied in 30g or 60g sizes. Keep tube tightly closed when not in use.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pp-safety-item info\"\u003e\n\u003cdiv class=\"ico-wrap\"\u003e\u003csvg class=\"ico\" viewbox=\"0 0 24 24\"\u003e\u003cuse href=\"#i-package\"\u003e\u003c\/use\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cstrong\u003eTravel Friendly\u003c\/strong\u003e\n\u003cp\u003eYes — both 30g and 60g tubes are well under the 100ml carry-on liquid limit. Avoid extreme heat in transit.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cmotion-element data-motion=\"fade-up\" data-motion-delay=\"200\"\u003e\u003cdiv class=\"pp-title\" id=\"pp-faq\"\u003e\n\u003cspan class=\"eyebrow\"\u003e13\u003c\/span\u003e\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003cspan class=\"num\"\u003eFAQ\u003c\/span\u003e\n\u003c\/div\u003e\u003c\/motion-element\u003e\n \n\u003cdiv class=\"pp-faq\"\u003e\n\u003cdiv class=\"pp-faq-item\"\u003e\n\u003cinput type=\"checkbox\" id=\"faq1\"\u003e\n\u003clabel for=\"faq1\"\u003eIs Duac Once Daily Gel pregnancy and breastfeeding safe?\u003c\/label\u003e\n\u003cdiv class=\"pp-faq-answer\"\u003e\n\u003cp\u003eUse with caution. According to the official Stiefel\/GSK Summary of Product Characteristics, there are no adequate data from use in pregnant women, and animal reproductive studies have not been conducted with the combination. Duac should only be used during pregnancy if the expected benefit justifies the potential risk to the fetus. For breastfeeding, percutaneous absorption is low, but it is not known whether clindamycin or benzoyl peroxide passes into human milk via topical use. Do not apply to the breast area while nursing. Always consult your obstetrician or dermatologist before use.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"pp-faq-item\"\u003e\n\u003cinput type=\"checkbox\" id=\"faq2\"\u003e\n\u003clabel for=\"faq2\"\u003eIs Duac Once Daily Gel fungal acne (Malassezia) safe?\u003c\/label\u003e\n\u003cdiv class=\"pp-faq-answer\"\u003e\n\u003cp\u003eYes. The Duac formulation contains no fatty acids, fatty alcohols, esters, polysorbates, or oils that feed Malassezia yeast (the organism responsible for pityrosporum folliculitis \/ fungal acne). The ingredient list — clindamycin phosphate, benzoyl peroxide, carbomer, dimethicone, disodium lauryl sulfosuccinate, disodium EDTA, glycerin, silica, poloxamer 182, water, and sodium hydroxide — is considered fungal-acne-trigger-free. Benzoyl peroxide also has some antifungal activity, which may help if you have mixed bacterial and fungal acne.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"pp-faq-item\"\u003e\n\u003cinput type=\"checkbox\" id=\"faq3\"\u003e\n\u003clabel for=\"faq3\"\u003eCan I use Duac with retinol, vitamin C, AHA, or BHA?\u003c\/label\u003e\n\u003cdiv class=\"pp-faq-answer\"\u003e\n\u003cp\u003eLayering requires care. Per the manufacturer's SPC, simultaneous application with tretinoin, isotretinoin, and tazarotene should be avoided because benzoyl peroxide can oxidize and inactivate retinoids and increase irritation. If your dermatologist prescribes both, apply them at different times of day (e.g., retinoid AM, Duac PM, or vice versa). For vitamin C: benzoyl peroxide can also oxidize L-ascorbic acid, so separate them by AM\/PM. AHA\/BHA exfoliants can multiply irritation when stacked with Duac — most dermatologists recommend pausing them during the first 4–6 weeks of treatment. Never combine Duac with topical or oral erythromycin due to drug antagonism.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"pp-faq-item\"\u003e\n\u003cinput type=\"checkbox\" id=\"faq4\"\u003e\n\u003clabel for=\"faq4\"\u003eWhat skin type is Duac best for?\u003c\/label\u003e\n\u003cdiv class=\"pp-faq-answer\"\u003e\n\u003cp\u003eDuac performs best on oily, combination, and acne-prone skin with mild to moderate inflammatory acne (red papules and pustules). It is the gold-standard prescription combination for these skin profiles. Dry and sensitive skin types can use it but should expect significant initial dryness, redness, and peeling — pair with a fragrance-free moisturizer and consider a lower-strength alternative such as Acanya (BPO 2.5%) or Onexton (BPO 3.75%). Avoid if you have rosacea, active eczema, or known allergy to clindamycin\/lincomycin.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"pp-faq-item\"\u003e\n\u003cinput type=\"checkbox\" id=\"faq5\"\u003e\n\u003clabel for=\"faq5\"\u003eHow long until I see results from Duac?\u003c\/label\u003e\n\u003cdiv class=\"pp-faq-answer\"\u003e\n\u003cp\u003eThe official Stiefel patient information leaflet states it may take 2–5 weeks to see the effect of Duac Once Daily Gel. In the five randomized Phase 3 clinical trials with 397 subjects, the primary efficacy endpoint was measured at week 11, with significant reductions in inflammatory lesion counts at lesion check-ins on weeks 2, 5, 8, and 11. Most users report visibly fewer breakouts within 3–4 weeks of consistent nightly use. Do not exceed 12 weeks of continuous use without a medical review.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"pp-faq-item\"\u003e\n\u003cinput type=\"checkbox\" id=\"faq6\"\u003e\n\u003clabel for=\"faq6\"\u003eWhere does Duac go in my skincare routine?\u003c\/label\u003e\n\u003cdiv class=\"pp-faq-answer\"\u003e\n\u003cp\u003eDuac is an evening (PM) treatment applied after cleansing and before moisturizing. The recommended sequence is: (1) gentle, fragrance-free cleanser, (2) wait 10–20 minutes for skin to fully dry, (3) apply a thin layer of Duac to the entire affected area, (4) wait 5 minutes, (5) apply a non-comedogenic moisturizer. In the morning, cleanse, moisturize, and always finish with broad-spectrum SPF 30+ — benzoyl peroxide significantly increases UV sensitivity. Do not layer Duac with retinoids or vitamin C in the same session.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"pp-faq-item\"\u003e\n\u003cinput type=\"checkbox\" id=\"faq7\"\u003e\n\u003clabel for=\"faq7\"\u003eIs Duac comedogenic — will it clog my pores?\u003c\/label\u003e\n\u003cdiv class=\"pp-faq-answer\"\u003e\n\u003cp\u003eNo. Duac has a comedogenic rating of 0\/5. The aqueous gel base contains no oils, butters, or comedogenic emollients. The inactive ingredients (carbomer, dimethicone, glycerin, silica, poloxamer 182, water, sodium hydroxide, disodium EDTA, disodium lauryl sulfosuccinate) are all rated 0–1 on standard comedogenicity scales. The active ingredients themselves — clindamycin and benzoyl peroxide — actively unclog pores rather than blocking them. If you experience purging in the first 2 weeks, this is the product surfacing existing clogs rather than creating new ones.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"pp-faq-item\"\u003e\n\u003cinput type=\"checkbox\" id=\"faq8\"\u003e\n\u003clabel for=\"faq8\"\u003eHow long does Duac last after opening?\u003c\/label\u003e\n\u003cdiv class=\"pp-faq-answer\"\u003e\n\u003cp\u003eDuac Once Daily Gel has a Period After Opening (PAO) of 2 months at room temperature once dispensed by the pharmacy. Per the Stiefel labeling, it should be stored at room temperature up to 25°C (77°F) and never frozen. Prior to dispensing, the pharmacy stores it refrigerated at 2–8°C (36–46°F) to preserve potency. Discard any remaining gel 60 days after the dispensing date — benzoyl peroxide degrades over time and loses efficacy. Always check the expiry date stamped on the tube crimp before use.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"pp-faq-item\"\u003e\n\u003cinput type=\"checkbox\" id=\"faq9\"\u003e\n\u003clabel for=\"faq9\"\u003eWill Duac bleach my towels and pillowcases?\u003c\/label\u003e\n\u003cdiv class=\"pp-faq-answer\"\u003e\n\u003cp\u003eYes. Benzoyl peroxide is a strong oxidizer and will permanently bleach colored fabrics, towels, pillowcases, hair, and carpeting on contact. To avoid damage: (1) use white pillowcases and towels during your Duac treatment, (2) wash your hands thoroughly after each application, (3) allow the gel to fully absorb (5–10 minutes) before contact with bedding, and (4) be cautious around dark clothing and dyed hair. The bleaching is irreversible — even a small smudge will leave a permanent orange or white mark.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"pp-verdict\"\u003e\n    \u003cdiv class=\"eyebrow\"\u003e— Skincarisma verdict\u003c\/div\u003e\n    \u003cdiv class=\"score-row\"\u003e\n      \u003cspan class=\"score\"\u003e4.3\u003c\/span\u003e\n      \u003cspan class=\"max\"\u003e\/ 5\u003c\/span\u003e\n      \u003cspan class=\"stars\"\u003e★★★★☆\u003c\/span\u003e\n    \u003c\/div\u003e\n    \u003cp class=\"text\"\u003e\n\u003cstrong\u003eVerdict:\u003c\/strong\u003e Duac Once Daily 10mg\/g + 50mg\/g Gel from Stiefel Laboratories remains a dermatology gold standard for mild-to-moderate inflammatory acne. The combination of 1% clindamycin and 5% benzoyl peroxide delivers fast, clinically validated results — most users see meaningful improvement within 2–5 weeks, with peak efficacy by week 11. The dual-action mechanism not only kills C. acnes bacteria but also prevents the antibiotic resistance seen with clindamycin monotherapy, making it superior to single-agent prescriptions. Drawbacks are well-documented and manageable: expect dryness, peeling, and sun sensitivity in the first two weeks, and budget for white pillowcases (benzoyl peroxide bleaches fabric). Not suitable for sensitive skin or pregnancy without medical supervision, and use is capped at 12 weeks to prevent resistance. For oily, combination, and acne-prone adolescents and adults seeking a once-daily prescription solution backed by five Phase 3 clinical trials, Duac Once Daily Gel is one of the most reliable, evidence-based choices on the market.\n\u003c\/p\u003e\n  \u003c\/div\u003e\n\n  \u003cbutton class=\"pp-back-to-top\" aria-label=\"Back to top\" type=\"button\" style=\"position:fixed;bottom:24px;right:24px;width:44px;height:44px;border-radius:50%;background:var(--pp-accent);color:#fff;border:none;display:none;cursor:pointer;z-index:50;box-shadow:0 4px 16px rgba(13,31,45,0.2)\"\u003e↑\u003c\/button\u003e\n  \u003cscript\u003e\n  (function () {\n    var btt = document.querySelector('.pp-back-to-top');\n    if (!btt) return;\n    var ticking = false;\n    function onScroll () {\n      if (!ticking) {\n        requestAnimationFrame(function () {\n          btt.style.display = window.scrollY \u003e 600 ? 'block' : 'none';\n          ticking = false;\n        });\n        ticking = true;\n      }\n    }\n    window.addEventListener('scroll', onScroll, { passive: true });\n    btt.addEventListener('click', function () { window.scrollTo({ top: 0, behavior: 'smooth' }); });\n  })();\n  \u003c\/script\u003e\n\u003c\/div\u003e\n","brand":"Stiefel Laboratories, Inc.","offers":[{"title":"Default Title","offer_id":52191496110423,"sku":null,"price":29.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0907\/5028\/8215\/files\/sxkcj31z6g4bepr3jd4teka0gq7d_square_2866b663-a758-4388-bc2c-fa28a31ea7e4.png?v=1775787882","url":"https:\/\/www.skincarisma.com\/products\/duac-once-daily-10mg-g-50mg-g-gel","provider":"Skincarisma","version":"1.0","type":"link"}