Tretinoin 0.05%
Tretinoin 0.05%
Product Description
Product overview
The first and only FDA-approved prescription tretinoin 0.05% in an innovative lotion base — uniquely formulated with sodium hyaluronate, soluble marine collagen, and glycerin for a hydrating retinoid experience. Clinically proven in two Phase 3 randomized controlled trials to significantly reduce both inflammatory and non-inflammatory acne lesions within 12 weeks, with lower rates of irritation than traditional tretinoin gels and creams.
Gold-Standard Retinoid
Tretinoin (all-trans retinoic acid) is the only FDA-approved topical retinoid for acne and the most studied anti-aging active in dermatology. At 0.05%, Altreno delivers clinically proven efficacy for both comedonal and inflammatory acne.
Texture & feel
SENSORYGold-Standard Retinoid
Tretinoin (all-trans retinoic acid) is the only FDA-approved topical retinoid for acne and the most studied anti-aging active in dermatology. At 0.05%, Altreno delivers clinically proven efficacy for both comedonal and inflammatory acne.
Unique Hydrating Lotion Base
Unlike traditional tretinoin gels and creams, Altreno's polymeric honeycomb mesh matrix delivers the active ingredient while simultaneously hydrating with sodium hyaluronate, soluble marine collagen, and glycerin — reducing the classic "retinization" dryness.
Phase 3 Clinically Proven
Two randomized, double-blind, vehicle-controlled trials in subjects aged 9+ showed statistically significant reductions in both inflammatory lesions (avg. −13.9 lesions vs. −10.7 vehicle) and non-inflammatory lesions (avg. −21.9 vs. −13.9 vehicle) over 12 weeks.
Soluble Marine Collagen
The soluble collagen (fish-derived) in the formula helps maintain the skin's moisture barrier and provides a plumping, cushioning effect within the lotion matrix. Note: caution in patients with known fish allergies.
Compatible with Makeup
A split-face controlled clinical study (Bhatia et al., 2020) demonstrated that Altreno is fully compatible with facial foundation makeup, making it practical for daytime use if needed — though evening application is still recommended.
Anti-Aging Bonus Benefit
While primarily FDA-approved for acne, tretinoin is extensively studied for photoaging. Regular use stimulates collagen synthesis, accelerates cell turnover, and reduces the appearance of fine lines, uneven tone, and sun damage over time.
Safety & compatibility
SAFETretinoin is a retinoid (vitamin A derivative). All retinoids — including topical tretinoin — are contraindicated during pregnancy due to potential teratogenic risk. Do not use Altreno if you are pregnant, planning to become pregnant, or think you may be pregnant. Consult your dermatologist immediately.
It is not known whether topical tretinoin is absorbed systemically in amounts sufficient to be detected in breast milk. Consult your healthcare provider to weigh the clinical benefit against any potential risk to the nursing infant before using Altreno while breastfeeding.
Altreno does not contain fatty acids, fermented ingredients, or problematic esters that feed Malassezia. Mineral oil, glycerin, and carbomers are all confirmed fungal-acne safe. This formula is generally considered safe for those managing malassezia folliculitis alongside acne.
Mineral oil is rated 0–1 on the comedogenic scale; glycerin and sodium hyaluronate are both non-comedogenic. Tretinoin itself actively unclogs pores, making Altreno a highly unlikely pore-clogger for most skin types.
Altreno contains soluble fish proteins (marine collagen). Use with caution if you have a known sensitivity or allergy to fish. Discontinue use and contact your healthcare provider immediately if you develop hives (urticaria) or itching during treatment.
Tretinoin increases photosensitivity significantly. Minimize unprotected UV exposure (sunlight and sunlamps). Apply broad-spectrum SPF 30+ sunscreen every morning without exception. Avoid sunburned skin before applying Altreno.
Avoid concurrent use with other potentially irritating topicals (benzoyl peroxide, salicylic acid, AHA/BHA, strong alcohol-based products) on the same skin area, as combining these may increase dryness and irritation. Discuss all skin medications with your prescriber.
Altreno contains methylparaben, a widely studied preservative used at safe cosmetic concentrations (under 1%). Current scientific consensus from the CIR and EU SCCS supports its safety in leave-on formulations at approved levels. Those with paraben sensitivity should be aware.
Ingredient breakdown
INGREDIENTSTretinoin 0.05%Gold Standard
Tretinoin (all-trans retinoic acid) is the active ingredient and a direct metabolite of vitamin A. It binds with high affinity to nuclear retinoic acid receptors (RARs), directly regulating gene expression involved in keratinocyte differentiation, sebum production, and inflammatory pathways. It is the only topical retinoid with direct FDA approval for acne vulgaris treatment.
- Mechanism: Normalizes follicular epithelial keratinization and desquamation, preventing microcomedone formation
- Anti-acne: Reduces both inflammatory lesions (avg. −13.9) and non-inflammatory lesions (avg. −21.9) vs. vehicle in Phase 3 trials
- Anti-aging: Stimulates procollagen type I & III synthesis; increases epidermal thickness; corrects photodamage (Kircik et al., 2019)
- Cell turnover: Accelerates shedding of dysfunctional corneocytes and promotes new, healthy keratinocyte proliferation
Sodium Hyaluronate SupportingProven
The sodium salt form of hyaluronic acid — a naturally occurring polysaccharide that holds up to 1,000x its weight in water. In Altreno's lotion matrix, it acts as a humectant that continuously draws moisture from the environment to hydrate skin throughout the day, partially counterbalancing the drying effects of tretinoin.
- Humectancy: Binds atmospheric moisture at the stratum corneum, reducing transepidermal water loss (TEWL)
- Barrier support: Helps maintain skin hydration, reducing perceived irritation during retinization
- Comedogenic rating: 0 — completely non-pore-clogging
Soluble Collagen SupportingProven
Marine-derived (fish) soluble collagen in Altreno's matrix functions as a film-forming moisturizer and skin-conditioning agent. It provides a smooth, non-greasy skin feel and helps the formula retain moisture at the surface. It forms the basis of Altreno's patented polymeric honeycomb mesh — enabling uniform distribution of tretinoin across the skin.
- Texture role: Contributes to Altreno's unique lotion consistency, distinguishing it from all other tretinoin formulations
- Skin feel: Imparts a silky, non-sticky finish that supports makeup compatibility (Bhatia et al., 2020)
- Uniform delivery: The collagen matrix allows consistent, controlled distribution of the tretinoin active across the skin surface
Glycerin SupportingProven
A well-established humectant and skin-conditioning agent derived from plant or synthetic sources. Glycerin draws moisture to the skin surface and into the upper layers of the stratum corneum, helping to maintain epidermal hydration and protect against irritation — a key benefit during the retinization phase of tretinoin therapy.
- Hydration: Proven to reduce TEWL and improve skin barrier function in clinical studies
- Tolerability: Helps buffer the irritation potential of tretinoin, supporting longer-term patient compliance
- Comedogenic rating: 0 — non-comedogenic, universally safe
Mineral Oil SupportingProven
A highly refined, purified petroleum-derived occlusive agent used in cosmetic-grade concentrations to seal in moisture and protect the skin's lipid barrier. Despite misconceptions, pharmaceutical-grade mineral oil is non-sensitizing, hypoallergenic, and rated 0–1 on the comedogenic scale when used in appropriate concentrations.
- Occlusive: Creates a breathable barrier that reduces TEWL without completely blocking oxygen exchange
- Tolerability: Used extensively in dermatology and pediatric formulations for its mildness and safety profile
- Fungal acne safe: Mineral oil does not promote Malassezia growth — confirmed FA-safe ingredient
13 ingredients total
Active: Tretinoin 0.05%
Inactive: Benzyl Alcohol, Butylated Hydroxytoluene (BHT), Carbomer Copolymer Type B (Pemulen TR-1), Carbomer Homopolymer Type A (Carbopol 981), Glycerin, Methylparaben, Mineral Oil, Octoxynol-9, Purified Water, Sodium Hyaluronate, Soluble Collagen, Trolamine
Where it fits in your routine
ROUTINEApply Altreno after cleansing to clean, dry skin at night. Wait 20–30 minutes before applying moisturizer to minimize dilution. Always use broad-spectrum SPF 30+ the next morning.
How to use
HOW TO USECleanse Gently
Wash the affected area with a mild, non-abrasive cleanser and lukewarm water. Pat skin completely dry — applying to damp skin increases penetration and the risk of irritation. Wait at least 10 minutes after washing before applying.
Apply a Pea-Sized Amount
Pump a pea-sized amount of Altreno onto your fingertip. This is enough to cover the entire face. Using too much will not increase efficacy — it will only increase the risk of irritation and dryness.
Spread Evenly Over Affected Areas
Gently spread the lotion across the face or affected skin in a thin, even layer. Avoid the eyes, mouth, corners of the nose (paranasal creases), and mucous membranes. If contact with these areas occurs, rinse thoroughly with water.
Let It Absorb (20–30 Minutes)
Allow Altreno to fully absorb before applying moisturizer. This waiting period helps prevent dilution of the active and reduces the risk of "balling" or product interference. Do not rinse off.
Apply Moisturizer
After the waiting period, apply a bland, non-comedogenic moisturizer to help manage dryness and reinforce the skin barrier. Look for humectant + occlusive combinations (e.g., ceramides + hyaluronic acid). This is especially important during the first 8–12 weeks of use.
Use SPF Every Morning
Tretinoin increases sun sensitivity significantly. Apply a broad-spectrum sunscreen (SPF 30 or higher) every morning, even on cloudy days or when indoors near windows. Protective clothing and hats are advised for prolonged outdoor exposure.
Introduce Slowly to Minimize Retinization
Week 1–2: Apply every 3rd night. Week 3–4: Every other night. Week 5+: Nightly as tolerated. This gradual introduction dramatically reduces the classic retinization period (purging, peeling, redness) and improves long-term adherence.
Who is it for?
WHOPerfect for you if:
- You have mild-to-severe acne vulgaris (blackheads, whiteheads, papules, pustules)
- You've been prescribed tretinoin and want a less-drying lotion format
- You previously experienced excessive irritation from tretinoin gels or creams
- You want a multi-benefit product that also addresses fine lines and photoaging
- You want to use makeup after application (proven compatible in clinical study)
- You have oily, combination, or normal skin that tolerates actives reasonably well
- You're aged 9 and older and have a valid prescription
- You're concerned about hydration while using a retinoid
Consider alternatives if:
- You are pregnant, breastfeeding, or planning pregnancy
- You have a known allergy or sensitivity to fish or fish proteins
- You have active eczema, rosacea, or severely compromised skin barrier
- You are looking for an over-the-counter (non-prescription) option
- Your budget does not allow for Rx pricing (~$115–$135 per tube)
- You need a retinoid safe for use during the day without sun protection
- You have previously been confirmed allergic to methylparaben
Skin type compatibility
SKIN TYPESIdeal — tretinoin reduces sebum production and unclogs congested pores. The lightweight lotion base won't add shine. Most tolerated retinoid format for oily skin types.
Works very well across T-zone and drier cheek areas. The hydrating lotion matrix helps balance dryness in drier zones while targeting oiliness and breakouts in the T-zone.
Better than gel or cream tretinoin for dry skin types thanks to the built-in hyaluronic acid and glycerin. However, a rich moisturizer applied after is still essential to prevent excessive peeling and tightness.
Any tretinoin can trigger sensitivity reactions. While Altreno's lotion formula is gentler than gels, those with reactive or sensitized skin should start very slowly (every 3rd night) and use a barrier repair moisturizer. Consult your dermatologist first.
Tretinoin is the gold standard for acne-prone skin. Altreno is FDA-approved specifically for acne vulgaris. Non-comedogenic formula (rating 1/5), fungal acne safe, and actively clears pore congestion from within.
Off-label, tretinoin 0.05% is one of the most evidenced topical treatments for fine lines, pigmentation, and photoaging. The lotion format with collagen and HA makes Altreno especially suitable for mature, drier skin seeking retinoid anti-aging benefits.
Results timeline
MONTHS 6–12Initial Skin Adjustment (Retinization)
Skin may appear slightly drier, flakier, or more sensitive than usual. This is the retinization phase — the skin adapting to accelerated cell turnover. Some users experience mild redness or peeling. Minimize with slow introduction and barrier-supportive moisturizing.
80% notice skin adjustmentPotential "Purging" Phase
Tretinoin accelerates cell turnover, which can temporarily bring existing microcomedones to the surface. Some users experience a brief acne "flare." This is a normal, expected phase and typically resolves before week 8. Stick with the regimen.
30–40% experience initial purgingVisible Improvement Begins
Inflammatory lesion counts begin declining. Skin texture starts improving. The retinization period resolves for most users. Pores appear cleaner and tighter. Consistent nightly use becomes easier as tolerance builds.
~55% see noticeable improvementClinically Proven Endpoint
By 12 weeks (the Phase 3 trial endpoint), Altreno demonstrated a mean reduction of 13.9 inflammatory lesions and 21.9 non-inflammatory lesions vs. vehicle. Treatment success (≥2-grade IGA improvement) was achieved in 16.5–19.8% of Altreno patients vs. 6.9–12.5% vehicle. Clear skin is not guaranteed but significant improvement is expected.
~19.8% achieve clear/almost clear skinAnti-Aging Benefits Emerge
With continued use, users begin noticing improvements in skin texture smoothness, reduction in hyperpigmentation and post-acne marks, and early signs of fine line reduction. Consistent use is required to maintain all benefits — acne can return when tretinoin is discontinued.
~70% notice improved skin textureRatings by platform
1K+ REVIEWSPros & cons
BALANCEDPraised
- Only tretinoin 0.05% available in a lotion — gentler than gels and creams
- Built-in hyaluronic acid and collagen reduce dryness during treatment
- FDA-approved with two Phase 3 RCT trials backing efficacy
- Clinically proven makeup compatibility — no interference with foundation
- Fragrance-free, silicone-free, alcohol-free formula
- Non-comedogenic (rating 1/5); fungal acne safe
- Approved from age 9 — suitable for teen acne
- Many users report significantly less irritation vs. generic tretinoin
Criticized
- High retail price (~$115–$135 per 45g tube without insurance)
- Not available as a generic — pharmacies may substitute regular tretinoin
- Contains fish-derived collagen — not suitable for those with fish allergies
- Contains methylparaben (a paraben preservative)
- Retinization period still occurs — initial purging and dryness expected
- Requires a valid prescription — not OTC accessible
- Some users find the lotion texture too heavy or occlusive in warm climates
- Increases sun sensitivity — daily SPF is non-negotiable
Budget-friendly alternatives (dupes)
DUPESThe same active ingredient at the same concentration — the generic is bioequivalent to brand-name tretinoin. The key difference is the base: generic creams or gels lack Altreno's sodium hyaluronate, collagen, and glycerin hydration matrix, making them potentially more irritating. For cost-conscious patients comfortable managing dryness with a separate moisturizer, generics are highly effective alternatives. Available with a standard tretinoin prescription at most pharmacies.
The only FDA-approved OTC retinoid for acne, adapalene 0.1% is gentler than tretinoin 0.05% with a lower irritation profile. It's an excellent starting point for retinoid beginners, those with sensitive skin, or anyone without access to a prescription. However, tretinoin is generally considered more potent, especially for anti-aging benefits. No prescription required — significant advantage over Altreno.
Curology offers prescriber-supervised custom tretinoin formulas (0.01%–0.1%) combined with other actives (niacinamide, azelaic acid, etc.) in a personalized, subscription-based model. The cost per month is lower than retail Altreno and includes online prescriber oversight. However, exact formulations vary per patient and the base may differ from Altreno's proprietary hydrating matrix. Good alternative for ongoing prescription access.
Retin-A Micro uses microsphere technology for slow-release tretinoin delivery, which may reduce irritation vs. standard gels while maintaining efficacy. Available in 0.04% and 0.1% concentrations. Like Altreno, it requires a prescription. At a similar or lower price point and without the fish protein concerns, it's a practical alternative — though it lacks the specific hydrating lotion matrix of Altreno.
Comparison with competitors
SIDE-BY-SIDEStorage & shelf life
12 MONTHS12 months after opening. Discard any remaining product after this period to ensure stability and efficacy of the tretinoin active.
Store at controlled room temperature: 20°–25°C (68°–77°F). Excursions permitted to 15°–30°C (59°–86°F). Protect from freezing. Keep away from direct light and heat sources. Store pump upright.
45g opaque tube with pump dispenser. The pump format ensures hygienic, mess-free dispensing and prevents contamination of the formula. The opaque packaging protects the light-sensitive tretinoin active from photodegradation.
At 45g / 1.6 oz, Altreno is borderline for carry-on liquid limits (most airlines allow up to 100ml/100g). As a prescription medication, carry your original pharmacy label and prescription documentation. May be placed in hold luggage without restriction.
Frequently asked questions
FAQNo. Altreno is NOT safe during pregnancy. Tretinoin is a retinoid (vitamin A derivative), and all retinoids are contraindicated in pregnancy due to the risk of teratogenicity (birth defects). Animal studies have shown malformations at doses close to the maximum recommended human dose. Although topical absorption is lower than oral retinoids, there are reports of birth defects in infants whose mothers used topical tretinoin. Do not use Altreno if you are pregnant, planning to become pregnant, or think you may be pregnant. For breastfeeding: the safety is unknown — it is not established whether absorbed tretinoin reaches breast milk in clinically significant amounts. Discuss with your prescriber before using while nursing.
Yes, Altreno is generally considered safe for those managing malassezia folliculitis (fungal acne). The formula does not contain fatty acids, ferments, esters, or polysorbates that are known to feed the Malassezia yeast. Glycerin, mineral oil, carbomers, sodium hyaluronate, and trolamine are all confirmed malassezia-safe ingredients. The soluble collagen (a protein, not a fatty acid) does not directly feed Malassezia. Additionally, by reducing comedonal acne and normalizing follicular keratinization, tretinoin may indirectly help improve skin conditions that accompany fungal acne.
Use with extreme caution or avoid concurrent application. Combining Altreno with other exfoliating or active ingredients — such as AHAs (glycolic, lactic acid), BHAs (salicylic acid), benzoyl peroxide, or vitamin C — significantly increases the risk of irritation, redness, peeling, and compromised barrier function. If you use vitamin C (L-ascorbic acid), apply it in the morning and Altreno at night on separate sessions. AHA/BHA products should be used on different nights, if at all, especially during the first 3 months of tretinoin therapy. Retinol is redundant if you are using prescription tretinoin — do not combine them. Always consult your prescribing dermatologist before combining actives.
Altreno is best suited for oily, combination, and acne-prone skin types — where tretinoin's pore-clearing, sebum-regulating, and anti-comedonal effects are most impactful. The unique hydrating lotion base (with hyaluronic acid, glycerin, and collagen) also makes it a better option for dry or normal skin types compared to standard tretinoin gels. While sensitive skin types can use Altreno, they should introduce it very gradually (every 3rd night initially) and use a generous barrier-supportive moisturizer. Those with active eczema or severely compromised skin barrier should wait until the skin has healed before starting tretinoin.
Clinical trials measured results at 12 weeks, which is the standard treatment endpoint. Most users begin noticing meaningful improvement in acne lesion counts between weeks 6–8. However, the first 2–4 weeks often involve a "retinization" period (purging, dryness, flaking) before improvement becomes visible. Anti-aging benefits (texture improvement, reduction in fine lines and pigmentation) typically take 6–12 months of consistent use to become apparent. Patience and consistency are critical — stopping tretinoin before the 12-week mark is the most common reason for perceived treatment failure.
Altreno should be applied after cleansing and toning (if used), and before moisturizer. The recommended sequence: (1) Gentle cleanser → (2) Toner (optional, avoid active toners) → (3) Altreno on dry skin → (4) Wait 20–30 minutes → (5) Moisturizer. The waiting period before moisturizer helps prevent dilution of the active and reduces the risk of product interaction. In the morning (AM routine), follow with SPF 30+ sunscreen — this is non-negotiable while using any retinoid. Altreno is formulated for nighttime use, though it was proven compatible with morning foundation application in clinical studies.
No — Altreno has a very low comedogenic risk (rated 1/5). The formula's key ingredients — glycerin (0), sodium hyaluronate (0), mineral oil (0–1), carbomers (0) — are all non-comedogenic or very low on the scale. More importantly, tretinoin itself is one of the most powerful anti-comedogenic actives available: it actively normalizes follicular keratinization and prevents the formation of microcomedones (the precursor to all acne lesions). Altreno is safe for acne-prone skin and is unlikely to clog pores in most users.
Altreno should be used within 12 months of opening (PAO: 12M). To maximize the shelf life of your tube: store it upright at room temperature (68–77°F / 20–25°C), protect it from freezing and direct light or heat, and replace the pump cap firmly after each use. The opaque tube packaging is designed to protect the tretinoin active from light-induced degradation. A 45g tube typically lasts 3–6 months with daily pea-sized application to the face, meaning one tube rarely approaches the 12-month limit under normal use.
Verdict: Altreno Tretinoin 0.05% Lotion earns its place as a genuine innovation in the retinoid category. By pairing prescription-strength, FDA-approved tretinoin with a hydrating matrix of sodium hyaluronate, soluble marine collagen, and glycerin, Ortho Dermatologics has created a meaningfully differentiated formula that addresses the most common barrier to tretinoin adherence: irritation and dryness. Two Phase 3 RCTs confirm its clinical efficacy for acne vulgaris, and its unique makeup-compatible lotion texture broadens its practical usability. The caveats are real — it's contraindicated in pregnancy, contains fish proteins that may concern some patients, and carries a premium price tag vs. generic tretinoin. But for patients who previously struggled with tretinoin side effects, or who want the gold-standard retinoid experience with built-in hydration,Altreno is among the best-formulated tretinoin options available by prescription.
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Product Overview
Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.
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Quick Product Notes
Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging «promises» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.
We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.
Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.
Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you
Notable Effects & Ingredients
Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.
We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.
A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.
One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!
Ingredients Related to Skin Types
Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.
EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.
Ingredient Safety Breakdown
Product ingredient list
| EWG | CIR | Ingredient Name & Cosmetic Functions | Notes |
|---|---|---|---|
| 0 |
Tretinoin
Skin Conditioning
|
Promotes Wound Healing
Dark Spots
Texture
Pores
|
|
| 5 |
Benzyl Alcohol
Solvent, Masking, Fragrance, Viscosity Decreasing Agent, Preservative, External Analgesic, Perfuming
|
|
|
| 6 |
BHT
Masking, Fragrance, Antioxidant
|
|
|
| 0 |
PEG/PPG-1/2 Copolymer
Solvent
|
|
|
| 2 |
Glycerin
Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant, Skin Conditioning
|
Promotes Wound Healing
Hydrating
|







