Acretin 0.05%
Acretin 0.05%
Product Description
Product overview
Acretin 0.05% Cream by Jamjoom Pharma is a prescription-strength topical tretinoin treatment designed to combat acne vulgaris, fade post-inflammatory hyperpigmentation, and smooth fine lines. With pharmaceutical-grade 0.05% all-trans retinoic acid in a minimalist 9-ingredient cream base, this dermatologist-trusted formula accelerates cell turnover, unclogs pores, and stimulates collagen production for visibly clearer, firmer, more even-toned skin.
FDA Gold-Standard Retinoid
Tretinoin is the only FDA-approved retinoid proven to treat both acne and photoaging at the cellular level.
Texture & feel
SENSORYFDA Gold-Standard Retinoid
Tretinoin is the only FDA-approved retinoid proven to treat both acne and photoaging at the cellular level.
Mid-Strength 0.05%
Up to 10x stronger than OTC retinol — the sweet spot between efficacy and tolerability for experienced users.
Accelerated Cell Turnover
Normalizes keratinization, unclogs pores, and stimulates collagen synthesis for smoother, firmer skin.
Minimalist 9-Ingredient Formula
No parabens, fragrances, or unnecessary fillers — a clean, medical-grade cream base built for tolerability.
Safety & compatibility
SAFETretinoin is contraindicated during pregnancy and lactation. Discontinue at least 1 month before trying to conceive.
Contains PEG-40 Stearate, Stearyl Alcohol, and Isopropyl Myristate, which may feed Malassezia yeast.
Tretinoin significantly raises photosensitivity. Daily broad-spectrum SPF 30+ is non-negotiable every morning.
Expect 2-6 weeks of dryness, flaking, redness, or a temporary purge before skin adjusts.
No added perfumes or drying alcohols — reduces irritation risk compared to some branded alternatives.
Do not combine with benzoyl peroxide, AHAs, BHAs, or vitamin C in the same routine without dermatologist guidance.
Do not use if you have rosacea, perioral dermatitis, acute eczema, or sunburned/broken skin.
Safety and efficacy in children under 10 years of age has not been established.
Ingredient breakdown
INGREDIENTSTretinoin 0.05%Proven
The all-trans form of retinoic acid — the only FDA-approved topical retinoid with decades of clinical data. Unlike retinol, which must convert through two metabolic steps, tretinoin binds directly to retinoic acid receptors and works immediately at the cellular level.
- Mechanism: Normalizes follicular keratinization, reduces sebum, and stimulates collagen synthesis.
- Clinical evidence: A 24-week trial of 0.05% tretinoin cream showed significant improvement in periorbital and forehead wrinkles, pigmentation, and overall photodamage scores.
- Potency: Mid-strength 0.05% is approximately 10× stronger than over-the-counter retinol formulations.
- Timeframe: Acne improvement typically appears after 6-8 weeks of consistent use; anti-aging effects require 12+ weeks.
PEG-40 Stearate ~3-5%Proven
A polyethylene glycol-based non-ionic surfactant and emulsifier that stabilizes the oil-and-water cream matrix. It allows tretinoin to distribute evenly across the skin and ensures the formula maintains a consistent texture throughout its shelf life.
- Function: Emulsifier, solubilizer, and skin-conditioning agent.
- Safety: Rated low-risk by the Cosmetic Ingredient Review (CIR) at used concentrations.
Stearyl Alcohol ~3-5%Proven
A fatty alcohol (not a drying alcohol) derived from vegetable sources. It acts as a thickener, emollient, and co-emulsifier, giving the cream its smooth, creamy texture and helping it glide over the skin without tugging.
- Function: Emollient and opacifying agent that softens the skin surface.
- Compatibility: Generally well-tolerated; does not cause the drying effect of simple alcohols like ethanol.
Isopropyl Myristate ~2-4%Proven
A lightweight synthetic ester widely used in pharmaceutical creams to enhance spreadability and boost skin penetration of the active ingredient. It reduces the greasy after-feel typical of heavier emollients.
- Function: Penetration enhancer and emollient.
- Benefit: Helps tretinoin distribute evenly and reach the target layers of the epidermis.
Stearic Acid ~2-4%Proven
A naturally-occurring saturated fatty acid that functions as a multi-tasker: emollient, thickener, and emulsion stabilizer. It helps bind the oil and water phases together while giving the cream body and a cushiony skin feel.
- Function: Emollient, surfactant, and viscosity controller.
- Source: Typically derived from vegetable oils (coconut, palm) or animal fats.
BHT (Butylated Hydroxytoluene) ~0.01-0.1%Proven
A synthetic antioxidant and preservative that prevents oxidative degradation of tretinoin, which is notoriously unstable when exposed to light and air. Without an antioxidant like BHT, the active ingredient would lose potency rapidly.
- Function: Antioxidant and active-ingredient stabilizer.
- CIR verdict: The Cosmetic Ingredient Review concluded that BHT used at typical cosmetic concentrations (0.01-0.1%) is safe and does not penetrate deeply enough to enter the bloodstream.
Sorbic Acid ~0.2%Proven
One of the most widely used preservatives in the world, also found in food. It is highly effective against mold and yeast, helping extend the shelf life of the cream and protect against microbial contamination.
- Function: Antifungal preservative.
- Profile: Gentle alternative to parabens, though may cause mild irritation in people with eczema.
Xanthan Gum ~0.1-0.3%Proven
A naturally-derived polysaccharide created by fermenting sugars. It is used as a thickener and stabilizer to give the cream its smooth, uniform texture and to prevent the active ingredient from separating out over time.
- Function: Natural thickener and stabilizer.
- Source: Bacterial fermentation ofXanthomonas campestris.
Purified Water BaseProven
The primary solvent and base of the cream formula. It dissolves water-soluble ingredients and, combined with the emulsifier system, creates a stable oil-in-water emulsion that feels lightweight and absorbs cleanly.
- Function: Solvent and carrier.
- Grade: Pharmaceutical-grade, free from microbial contamination.
9 ingredients
Tretinoin 0.05% w/w, Polyoxyl 40 Stearate (PEG-40 Stearate), Stearyl Alcohol, Isopropyl Myristate, Stearic Acid, Butylated Hydroxytoluene (BHT), Sorbic Acid, Xanthan Gum, Purified Water.
Where it fits in your routine
ROUTINEApply at night only. Always wait for skin to be fully dry before applying tretinoin — this reduces irritation. In the morning, broad-spectrum SPF 30+ is essential to protect the freshly-turned-over skin.
How to use
HOW TO USECleanse Gently
Wash face with a mild, non-foaming cleanser and lukewarm water. Pat dry with a clean towel — do not rub.
Wait 20-30 Minutes
Allow skin to fully dry before application. Applying to damp skin dramatically increases irritation and penetration depth.
Dispense a Pea-Sized Amount
Squeeze about ½ inch of cream onto a fingertip. This is enough for the entire face — more does not equal better results.
Apply in Thin Layer
Dot onto forehead, cheeks, chin, and nose. Gently spread across the face, avoiding the eye area, corners of the nose, and lips.
Start Slow (2-3 Nights/Week)
For the first 2-4 weeks, use every 2nd or 3rd night. Gradually increase to nightly use as tolerance builds.
Follow with Moisturizer
After 20 minutes, apply a non-comedogenic moisturizer to buffer irritation and support the skin barrier.
Morning SPF (Non-Negotiable)
Apply broad-spectrum SPF 30 or higher every morning — tretinoin significantly increases UV sensitivity.
Who is it for?
WHOPerfect for you if:
- You have moderate to persistent acne vulgaris that has not responded to OTC treatments
- You have experience with retinol and want to step up to prescription-strength tretinoin
- You are targeting fine lines, photoaging, uneven texture, or post-acne marks (PIH)
- You have oily or combination skin with enlarged pores
- You are committed to long-term use (minimum 3-6 months) and daily SPF
- You have a dermatologist's prescription or guidance for use
Consider alternatives if:
- You are pregnant, breastfeeding, or actively trying to conceive
- You have rosacea, perioral dermatitis, or acute eczema
- You have very sensitive skin and are new to retinoids (start with 0.025% instead)
- You are prone to fungal acne (Malassezia folliculitis)
- You cannot commit to daily broad-spectrum sunscreen
- You use heavy exfoliating acids (AHA/BHA) or benzoyl peroxide daily
Skin type compatibility
SKIN TYPESOriginally designed for oily acne-prone skin. Reduces sebum production and clears congested pores effectively.
May cause significant dryness and flaking. Requires heavy moisturizer buffering; consider 0.025% strength first.
Works well on T-zone congestion; apply lighter amounts to drier cheek areas and pair with rich moisturizer.
Not recommended as a first retinoid. Start with 0.025% or use the sandwich method with moisturizer.
Gold-standard treatment for acne vulgaris. Clears comedones, reduces inflammation, and prevents future breakouts.
Clinically proven to reduce fine lines, wrinkles, and photoaging through collagen stimulation over 12+ weeks.
Results timeline
MONTH 6+Retinization Phase
Skin begins adjusting. Expect mild redness, slight flaking, and a temporary "retinoid burn" sensation. This is normal and temporary.
90% experience thisThe Purge
Accelerated cell turnover pushes underlying comedones and clogged pores to the surface. Breakouts may temporarily worsen before improving.
~65% experience purgingFirst Clear Improvements
Inflammatory acne lesions reduce noticeably. Skin tone becomes more even, pores appear refined, and texture starts smoothing.
70% see clear improvementFull Acne Clearance
Clinical studies show peak anti-acne efficacy at 12 weeks. Most users report significantly clearer skin and fading post-inflammatory marks.
85% noticeable improvementAnti-Aging Benefits Appear
Collagen synthesis becomes visible: fine lines soften, skin firmness improves, and photoaging markers decrease. Continue for sustained results.
75% report smoother skinRatings by platform
2K+ REVIEWSPros & cons
BALANCEDPraised
- Pharmaceutical-grade 0.05% tretinoin at a fraction of the cost of branded alternatives
- Minimalist 9-ingredient formula free from parabens, fragrance, and allergens
- Highly effective for acne clearance within 8-12 weeks
- Proven anti-aging benefits including wrinkle reduction and collagen stimulation
- Fades post-inflammatory hyperpigmentation and dark spots
- Compact aluminum tube — travel-friendly and protects from light degradation
- Trusted by dermatologists across the Middle East and internationally
Criticized
- Significant initial purging phase (3-8 weeks) that discourages some users
- Prescription-only in most countries; limited OTC availability
- Not pregnancy or breastfeeding safe — strict contraindication
- Causes dryness, flaking, and photosensitivity, especially at first
- Slight "pharma" or mayonnaise-like scent noted by some users
- Contains isopropyl myristate (moderate comedogenic rating)
- Not fungal-acne safe due to PEG emulsifiers and fatty alcohols
Budget-friendly alternatives (dupes)
DUPESNearly identical 0.05% tretinoin concentration with a slightly richer emollient base (adds squalane and glycerin). Contains parabens, unlike Acretin.
Identical active ingredient at the same concentration. Formula excipients vary by manufacturer — potency may be less consistent than branded pharma products.
Over-the-counter third-generation retinoid. Gentler than tretinoin with comparable acne results, but slower to show anti-aging effects.
Uses retinal (retinaldehyde), one step closer to retinoic acid than retinol. No prescription needed but significantly weaker than 0.05% tretinoin.
Comparison with competitors
SIDE-BY-SIDEGalderma Retacnyl 0.05%
Storage & shelf life
6 MONTHS6 months after opening. Tretinoin is light and air-sensitive — potency degrades once the tube is opened.
Store at room temperature (15-25°C / 59-77°F). Keep away from direct sunlight, heat, and humidity. Do not refrigerate.
Aluminum collapsible tube — opaque and airtight, protecting the unstable tretinoin molecule from light degradation.
Yes — 30g is well under TSA liquid limits. Keep in original packaging to protect from light during travel.
Frequently asked questions
FAQNo. Acretin 0.05% contains tretinoin, which is strictly contraindicated during pregnancy, while trying to conceive, and during breastfeeding. Topical tretinoin can be absorbed through the skin and is associated with potential teratogenic effects. According to the official product labeling from Jamjoom Pharma, the product should not be used during pregnancy. Discontinue use at least one month before planning to conceive, and consult your dermatologist for pregnancy-safe alternatives such as azelaic acid 15-20%.
No. Acretin 0.05% is not considered fungal-acne safe. It contains PEG-40 Stearate (a polysorbate/PEG emulsifier), Stearyl Alcohol (a fatty alcohol), and Isopropyl Myristate — all of which can feed Malassezia yeast and potentially worsen pityrosporum folliculitis. If you are specifically treating fungal acne, consult your dermatologist about fungal-safe retinoid alternatives like adapalene gels with cleaner excipient lists.
Not simultaneously in the same routine. Layering Acretin 0.05% with other retinoids (retinol, retinal) is redundant and increases irritation without added benefit. Combining with AHAs (glycolic, lactic) or BHAs (salicylic) in the same application significantly raises the risk of chemical burns, barrier damage, and peeling. Vitamin C can be used in the morning, while Acretin is applied at night — this is a safe and synergistic approach. Always separate strong actives by at least 12 hours, and introduce new products one at a time.
Acretin 0.05% is best suited for oily, combination, and acne-prone skin — particularly those with experience using lower-strength retinoids (0.025% tretinoin or OTC retinol). It is also excellent for mature skin concerned about photoaging, fine lines, and uneven pigmentation. Those with sensitive skin, rosacea-prone skin, or new retinoid users should consider starting with the 0.025% version first. Very dry skin types will need robust moisturizer buffering to tolerate this strength.
According to the manufacturer's clinical data, you can expect initial skin improvement after 6-8 weeks of consistent nightly use. Acne lesion counts typically reduce significantly by week 8-12. During the first 2-6 weeks, expect a retinization period with dryness and possible purging — this is normal and temporary. Full anti-aging benefits (fine line reduction, improved firmness, photoaging reversal) require 3-6 months of continuous use. Patience and consistency are essential.
Apply Acretin 0.05% at night only, after cleansing and before moisturizer. Start with a gentle cleanser, wait 20-30 minutes for skin to dry completely, then apply a pea-sized amount of Acretin across the face. Wait another 15-20 minutes before layering your moisturizer on top. This "sandwich method" (moisturizer-tretinoin-moisturizer) can also be used to reduce irritation for sensitive users. In the morning, always apply broad-spectrum SPF 30 or higher.
The formula has a comedogenic rating of approximately 3/5 due to the presence of Isopropyl Myristate, which is moderately pore-clogging for some individuals. However, the active tretinoin itself is strongly anti-comedogenic — it actively unclogs pores and prevents new comedones from forming. In practice, most users find that the anti-acne benefits of tretinoin outweigh the mild comedogenic risk of the base ingredients. If you are extremely sensitive to clogging, consider tretinoin in a gel base instead.
The period after opening (PAO) for Acretin 0.05% is approximately 6 months. Tretinoin is a notoriously unstable molecule that degrades rapidly when exposed to light, air, and heat — which is why the product comes in an opaque aluminum tube with BHT added as an antioxidant stabilizer. Always replace the cap tightly after use, store at room temperature away from direct sunlight, and avoid bathroom storage where humidity can compromise stability. Do not use beyond the printed expiration date.
Verdict: Acretin 0.05% by Jamjoom Pharma is a pharmacy-grade tretinoin cream that delivers the gold-standard acne and anti-aging results of prescription retinoids at a fraction of the cost of branded alternatives like Retin-A. Its minimalist 9-ingredient formula — free from parabens, fragrance, and common allergens — is a clear advantage over older branded competitors that still rely on parabens and complex excipient systems. Best suited for experienced retinoid users with oily or acne-prone skin who are ready for prescription-strength results and committed to daily SPF. Not recommended for pregnancy, sensitive or rosacea-prone skin, or complete retinoid beginners (start with 0.025% instead). With patience through the retinization period, this is one of the most effective and budget-friendly prescription tretinoins available.
Product Overview
Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.
Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.
Quick Product Notes
Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging «promises» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.
We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.
Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.
Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you
Notable Effects & Ingredients
Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.
We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.
A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.
One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!
Ingredients Related to Skin Types
Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.
EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.
Ingredient Safety Breakdown
Product ingredient list
| EWG | CIR | Ingredient Name & Cosmetic Functions | Notes |
|---|---|---|---|
| 0 |
Tretinoin
Skin Conditioning
|
Promotes Wound Healing
Dark Spots
Texture
Pores
|
|
| 0 |
PEG-40 Stearate
Emulsifying
|
|
|
| 1 |
Stearyl Alcohol
Emulsion Stabilising, Fragrance, Emulsifying, Surfactant, Viscosity Increasing Agent, Emollient, Foam Boosting, Masking, Opacifying, Refatting, Viscosity Controlling
|
|
|
| 1 |
Isopropyl Myristate
Solvent, Skin Conditioning, Perfuming, Emollient, Fragrance, Binding Agent, Binding
|
|
|
| 1 |
Stearic Acid
Masking, Fragrance, Emulsion Stabilising, Emulsifying, Sufactant, Refatting, Cleansing
|
|





