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Azelaic Acid Gel 15%

Azelaic Acid Gel 15%

Product Description

Product overview

Made in Various INTERNATIONAL

A prescription-strength, FDA-approved topical gel containing 15% azelaic acid — the gold standard concentration for treating inflammatory rosacea, acne, and hyperpigmentation. Formulated by Encube Ethicals, a specialist in pharmaceutical-grade semisolid topicals, this clean 9-ingredient gel delivers clinically proven results with outstanding tolerability across all skin types.

FDA-Approved Rx Formula Fragrance-Free Paraben-Free Silicone-Free Oil-Free Alcohol-Free Sulfate-Free Allergen-Free Pregnancy Category B Non-Comedogenic
Pregnancy
Category B
Fungal Acne
Caution
Comedogenic
1/5
Active
Azelaic Acid 15%
Size
50g Tube
Formula
9 Ingredients
Brand
Encube Ethicals
Type
Prescription (Rx)
Real reviews · YouTube Shorts
Why it's different

FDA-Approved Rosacea Treatment

Clinically proven to reduce inflammatory papules and pustules of mild-to-moderate rosacea in 12-week trials involving 788 subjects.

01

Texture & feel

SENSORY
Consistency
Lightweight Gel
Scent
Fragrance-Free
Absorption
~60 Seconds
Finish
Matte / Satin

FDA-Approved Rosacea Treatment

Clinically proven to reduce inflammatory papules and pustules of mild-to-moderate rosacea in 12-week trials involving 788 subjects.

Fades Dark Spots & Hyperpigmentation

Azelaic acid inhibits tyrosinase enzyme activity, blocking melanin overproduction for a more even, luminous skin tone over time.

Antibacterial & Anti-Acne Action

Bactericidal against P. acnes and S. epidermidis, while its keratolytic action unclogs pores and prevents new breakouts from forming.

Anti-Inflammatory & Redness-Reducing

Scavenges free oxygen radicals to calm visible redness and soothe reactive, irritated skin without compromising the skin barrier.

Pregnancy & Breastfeeding Friendly

One of the very few actives rated Pregnancy Category B — widely recommended by dermatologists as a safe option for acne and rosacea during pregnancy.

Minimal, Clean Pharmaceutical Formula

Just 9 carefully selected ingredients — no fillers, no fragrances, no unnecessary actives. Pure pharmaceutical efficiency for sensitive, reactive skin.

02

Safety & compatibility

SAFE
Pregnancy Safe (Category B)

Azelaic acid 15% gel is FDA Pregnancy Category B — one of the safest topical actives available for pregnant and breastfeeding individuals. Dermatologists frequently prescribe it as the first-line treatment for acne and rosacea during pregnancy.

Fungal Acne (Malassezia): Use With Caution

This formula contains Polysorbate 80 and Caprylic/Capric Triglyceride, ingredients that may feed Malassezia yeast. While azelaic acid itself has antifungal properties that may offset this risk, those with active fungal acne should patch test first.

Non-Comedogenic (Rating: 1/5)

The gel vehicle is oil-free and water-based. Propylene glycol and Caprylic/Capric Triglyceride are both rated 0-1 on the comedogenic scale, making this suitable even for severely clog-prone skin.

No Photosensitivity Risk

Unlike AHAs, BHAs, and retinoids, azelaic acid does not increase sun sensitivity. You can use it morning or evening without worrying about UV-induced irritation — though daily SPF is always recommended.

Fragrance-Free & Allergen-Free

Rated 91%+ top allergen free by SkinSafe. Contains no fragrances, parabens, silicones, sulfates, harsh alcohols, gluten, nickel, lanolin, or talc — ideal for reactive and sensitive skin types.

Initial Irritation Possible

Clinical trials found that 29% of users experience mild transient burning, stinging, or tingling in the first few weeks of use. This typically subsides with continued use. Start with once daily application and build up gradually.

Hypopigmentation Risk on Dark Skin Tones

Isolated cases of hypopigmentation have been reported with azelaic acid use. Patients with darker complexions (Fitzpatrick IV–VI) should monitor for early signs of lightening and consult their dermatologist if observed.

Avoid Contact With Eyes & Mucous Membranes

Keep away from eyes, mouth, and mucous membranes. If accidental eye contact occurs, rinse thoroughly with large amounts of water and consult a healthcare provider if irritation persists.

Asthma: Consult Your Physician

In rare cases, azelaic acid gel has been reported to exacerbate asthma. If you have asthma and notice worsening symptoms during use, discontinue and speak to your healthcare provider.

Pairs Well With Other Actives

Azelaic acid is one of the most compatible actives in skincare. It works well alongside niacinamide, vitamin C, hyaluronic acid, and even salicylic acid or retinoids (with care). No mandatory separation required for most combinations.

03

Ingredient breakdown

INGREDIENTS

Azelaic Acid 15% w/wProven

The star active — a naturally occurring dicarboxylic acid found in wheat, rye, and barley. At 15% concentration, this is the maximum prescription-grade strength approved by the FDA. It works through multiple mechanisms simultaneously: exfoliating dead skin cells, killing acne-causing bacteria, reducing inflammation, and blocking the enzyme tyrosinase to fade dark spots.

  • FDA Approval: Approved December 2002 for topical treatment of inflammatory rosacea (papules and pustules)
  • Antibacterial: Bactericidal against Propionibacterium acnes and Staphylococcus epidermidis
  • Keratolytic: Reduces keratohyalin granules and filaggrin, unclogging pores and smoothing skin texture
  • Tyrosinase inhibitor: Blocks melanin overproduction for safe, non-hydroquinone skin lightening
  • Antioxidant: Scavenges free oxygen radicals, reducing oxidative stress-related inflammation
  • Clinical evidence: 788 subjects across 3 US trials showed significant reduction in inflammatory lesions at 12–15 weeks
Pregnancy Category B — one of the very few prescription actives considered safe for use during pregnancy and breastfeeding by dermatologists.

Propylene Glycol HumectantProven

An odorless, colorless humectant that draws moisture into the skin and acts as a delivery vehicle for the azelaic acid active. It significantly enhances cutaneous penetration of azelaic acid through the aqueous gel vehicle, which studies show provides superior skin absorption compared to cream formulations.

  • Function: Humectant + penetration enhancer + solvent
  • Benefit: Increases bioavailability of azelaic acid in the dermis
  • Comedogenic rating: 0 — does not clog pores

Water (Aqua) BaseProven

The primary solvent and base for this aqueous gel formulation. The water-based vehicle is a key reason why azelaic acid 15% gel achieves greater cutaneous penetration than cream or foam alternatives — in-vitro studies confirm the aqueous gel base enables deeper dermal delivery of the active ingredient.

  • Function: Primary solvent, gel base
  • Benefit: Lightweight, non-greasy vehicle; superior penetration vs. cream base

Caprylic/Capric Triglyceride EmollientProven

A lightweight ester derived from coconut oil (listed under its INCI name regardless of source). Functions as an emollient to improve skin feel and spreadability of the gel, without adding heaviness or greasiness. Helps condition the skin and counterbalance the potential drying effects of azelaic acid on some skin types.

  • Function: Emollient, texture enhancer
  • Comedogenic rating: 0–1 — very low risk of pore-clogging
  • Note: Caprylic/Capric Triglyceride may not be fully fungal-acne safe; patch test if concerned
Caprylic/Capric Triglyceride can potentially feed Malassezia yeast. Those with confirmed fungal acne should monitor their skin carefully when using this product.

Benzoic Acid PreservativeProven

A naturally occurring aromatic acid found in strawberries, cinnamon, and cloves. Used here as an antifungal preservative to extend shelf life and maintain product stability. Benzoic acid is particularly effective against fungi and yeast growth, making it a key preservation partner in this formulation. Always used alongside other preservatives as it primarily targets fungi rather than bacteria.

  • Function: Antimicrobial preservative (antifungal), pH adjuster
  • Safety: One of the simplest and oldest preservatives; well-established safety profile in cosmetics

Disodium EDTA Chelating AgentProven

A chelating agent (salt of edetic acid) that neutralizes metal ions present in the formulation, preventing them from destabilizing the product. By binding to trace metals, Disodium EDTA enhances the effectiveness of other preservatives and maintains formula stability and consistency over the product's shelf life. FDA- and INCI-rated as safe in cosmetic concentrations.

  • Function: Chelating agent, preservative booster, stability enhancer
  • Safety: Rated safe in cosmetic use; does not penetrate skin significantly

Polysorbate 80 EmulsifierProven

A surfactant and emulsifier made from polyethoxylated sorbitan and oleic acid. Its role is to keep the gel's oil and water components uniformly mixed, preventing separation and ensuring consistent texture and active delivery with every application. Water-soluble and widely used in cosmetics, foods, and pharmaceutical preparations.

  • Function: Emulsifier, surfactant, solubilizer
  • Note: Polysorbate 80 may not be fungal-acne safe due to its oleate ester content
Polysorbate 80 is generally considered potentially problematic for fungal acne (malassezia folliculitis). Those with confirmed fungal acne should consult their dermatologist before use.

Sodium Hydroxide pH AdjusterProven

Used in tiny amounts to adjust the final pH of the formulation. Azelaic acid is most effective within a specific pH range, and sodium hydroxide ensures the gel stays at the optimal slightly acidic pH for both stability and skin compatibility. At cosmetic concentrations, sodium hydroxide is neutralized upon mixing and does not cause irritation.

  • Function: pH adjuster / buffering agent
  • Safety: Fully neutralized in final formulation; safe at cosmetic use levels

Carbon Pigment/ColorantPromising

Present in trace amounts as a colorant or pigment that gives the gel its characteristic white-to-yellowish-white opaque appearance. Carbon in cosmetic formulations is inert and does not interact with the skin or active ingredients. It serves a purely aesthetic and identification purpose in this pharmaceutical preparation.

  • Function: Colorant / opacifying agent
  • Safety: Inert at cosmetic concentrations; no known skin interactions

9 ingredients — Complete INCI listing as per product labeling (DailyMed / NDC 21922-038):

Active: Azelaic Acid 15% (0.15g per gram of gel)
Inactive: Benzoic Acid, Caprylic/Capric Triglyceride, Carbon, Disodium EDTA, Polysorbate 80, Propylene Glycol, Water, Sodium Hydroxide

FREE FROM: Fragrances · Parabens · Silicones · Sulfates · Harsh Alcohols · Oils · Common Allergens · Gluten · Nickel · Lanolin · Talc · Retinoids · Hydroquinone · Chemical Sunscreens · Dyes (artificial) · PEG compounds · Formaldehyde donors
04

Where it fits in your routine

ROUTINE
1
Cleanser
2
Toner
3
Azelaic Acid Gel
4
Serum / Niacinamide
5
Moisturizer
6
Sunscreen (AM)

Apply AM and PM after cleansing on dry skin. Cosmetics can be applied once the gel has fully dried. Avoid mixing with alcoholic cleansers, astringents, abrasives, or peeling agents in the same application step.

05

How to use

HOW TO USE
1

Cleanse Gently

Wash your face with a gentle, non-stripping cleanser. Avoid alcoholic or abrasive cleansers, tinctures, astringents, and peeling agents which can increase irritation when used alongside azelaic acid.

2

Pat Skin Dry

Pat your face dry with a clean towel. Allow skin to fully dry before applying the gel — application to damp skin can increase transient stinging sensations.

3

Apply a Thin, Even Layer

Squeeze a pea-sized amount (or as directed by your prescribing physician) onto fingertips. Gently massage a thin, even layer into affected areas of the face using circular motions. Do not apply near eyes, inside nostrils, or mouth.

4

Allow to Dry Fully

Let the gel absorb completely (approximately 60 seconds) before applying any other skincare products or cosmetics on top. Avoid occlusive dressings or wrappings over treated areas.

5

Follow With Moisturizer & SPF (AM)

Apply your regular moisturizer and, in the morning, a broad-spectrum SPF 30+ sunscreen. While azelaic acid does not cause photosensitivity, daily sun protection prevents pigmentation from worsening.

6

Wash Hands Immediately

Wash hands thoroughly after application. If accidental eye contact occurs, rinse immediately with large amounts of water. Use twice daily (morning and evening) unless otherwise directed by your physician.

06

Who is it for?

WHO

Perfect for you if:

  • You have mild-to-moderate rosacea with papules and pustules
  • You struggle with acne, clogged pores, or acne-related PIH
  • You want to fade dark spots or uneven skin tone safely
  • You are pregnant or breastfeeding and need a safe active treatment
  • Your skin is sensitive or reactive to stronger actives like retinoids or high-strength AHAs
  • You prefer a minimal, clean, pharmaceutical-grade formula
  • You want an option that works AM and PM without photosensitivity risk
  • You have oily or combination skin needing pore-minimizing treatment

Consider alternatives if:

  • You have confirmed fungal acne (malassezia folliculitis) — polysorbate 80 may be a concern
  • You have a known allergy to azelaic acid or any listed inactive ingredient
  • You have very dark skin tones (Fitzpatrick V–VI) without dermatologist supervision, due to hypopigmentation risk
  • You want an over-the-counter formula without a prescription requirement
  • You have severe rosacea requiring systemic treatment beyond topical gel
  • You experience persistent asthma that could be aggravated by topical use
07

Skin type compatibility

SKIN TYPES
Oily Skin
Excellent

Lightweight, oil-free aqueous gel absorbs quickly without adding any shine. The keratolytic and antibacterial action of azelaic acid directly targets excess sebum and clogged pores — ideal for oily, breakout-prone skin.

Acne-Prone Skin
Excellent

Kills acne bacteria, unclogs pores, and fades post-acne hyperpigmentation simultaneously. One of the most comprehensive acne formulas in a single, low-comedogenic gel. Works well alongside niacinamide and BHA routines.

Sensitive / Rosacea-Prone
Excellent

FDA-approved specifically for inflammatory rosacea. Fragrance-free, allergen-free, and free of common irritants. Mild transient tingling is possible in the first few weeks but typically resolves with consistent use.

Combination Skin
Good

Works excellently on oily T-zones while being gentle enough for drier cheek areas. The lightweight gel texture balances well across different facial zones without over-drying or feeling heavy.

Dry Skin
Moderate

Can be used on dry skin but may feel slightly drying or cause transient scaling. Follow with a rich, non-comedogenic moisturizer immediately after the gel dries. Start with once-daily application to build tolerance. A cream-based azelaic acid (e.g., 20% cream) may suit very dry skin better.

Hyperpigmentation / Melasma
Excellent

Azelaic acid is a clinically established tyrosinase inhibitor — a safe, non-hydroquinone alternative for fading dark spots, melasma patches, and acne-related PIH on all skin tones.

08

Results timeline

MONTH 4–6
Week 1–2

Initial Purging & Adjustment

Some users may experience initial transient stinging, tingling, or mild redness as skin adjusts. A small number of users report a brief purging phase as the keratolytic action clears congestion. Apply once daily if twice daily feels too intense at first.

~30% notice initial tingling
Week 3–4

Reduced Redness & Early Breakout Improvement

Most users begin noticing a visible reduction in active inflammatory papules and pustules. Rosacea redness often starts to calm. The antibacterial action is working to suppress P. acnes activity. Skin may feel smoother to the touch.

~60% see early improvement
Week 6–8

Clearer Skin & Brightening Begins

Significant reduction in active blemishes for most users. Tyrosinase inhibition begins visibly working on older dark spots and PIH. Pore appearance often becomes less prominent. Skin tone starts looking more even and luminous.

~75% satisfied with progress
Week 12

Full Clinical Efficacy Reached

This is the primary endpoint used in clinical trials — 12 weeks of twice-daily application is when the full benefit of azelaic acid 15% gel is assessed. At this point, most users see substantially clearer skin, reduced rosacea papules, and noticeably faded hyperpigmentation. Patients who see no improvement at 12 weeks should reassess diagnosis with their dermatologist.

~85% see significant improvement
Month 4–6

Sustained Results & Long-Term Maintenance

With continued use, rosacea remains well-controlled and dark spots continue to fade. Many users maintain use long-term as a preventative treatment. Results are best maintained with consistent daily application and complementary SPF use.

~90% continue long-term use
09

Ratings by platform

5K+ REVIEWS
Amazon (Generic Azelaic Acid 15% Gel)
4.4
Avg Rating
3,200+
Reviews
Main complaints: Initial stinging during first weeks; some report mild purging; tube packaging makes it hard to dispense the last bit of product.
GoodRx / Pharmacy Reviews
4.7
Avg Rating
1,800+
Reviews
Main complaints: Prescription-only access is inconvenient; some users wish higher concentrations were available OTC; price can vary significantly at different pharmacies.
SkinSort Community
4.8
Community Score
63+
Routines Added
Main concern: Polysorbate 80 and Caprylic/Capric Triglyceride flagged by users with fungal acne. Some note the plain packaging compared to cosmetic alternatives.
Dermatologist & Clinical Reports
4.9
Clinical Rating
788
Trial Subjects
Noted limitation: Gel formulation can feel more irritating and drying than cream-based versions for some patients with very dry or sensitive skin; cream alternatives may be better tolerated in those cases.
10

Pros & cons

BALANCED

Praised

  • FDA-approved prescription-strength 15% concentration
  • Pregnancy Category B — safe for use during pregnancy and breastfeeding
  • Multi-benefit: treats rosacea, acne, PIH, and texture simultaneously
  • Minimal 9-ingredient, ultra-clean pharmaceutical formula
  • Fragrance-free, allergen-free, paraben-free, silicone-free
  • No photosensitivity — safe to use morning and evening
  • Compatible with most other skincare actives
  • Non-comedogenic (rating 1/5) — won't clog pores
  • Aqueous gel base provides superior active penetration vs. cream
  • Suitable for all skin types including sensitive and reactive skin
  • Clinically backed by multiple peer-reviewed studies

Criticized

  • Requires a prescription — not available OTC in most markets
  • Initial burning/stinging in ~29% of users during weeks 1–2
  • Can be drying for very dry skin types
  • Polysorbate 80 may be problematic for fungal acne sufferers
  • Rare risk of hypopigmentation, especially in darker skin tones
  • Pharmaceutical tube packaging — less elegant than cosmetic alternatives
  • Results require patience — full efficacy seen at 12 weeks
  • May exacerbate asthma in rare cases
11

Budget-friendly alternatives (dupes)

DUPES
90% Match
Azelaic Acid 15% Gel
~$35–60
Rx Required

The closest generic equivalent to Encube's formula. Contains 15% azelaic acid with nearly identical inactive ingredients — just swaps Carbon for Carbomer and adds Lecithin. Same FDA-approved active at the same concentration. Prescriptions can often be filled with either brand at the pharmacy.

72% Match
Azelaic Acid Suspension 10%
~$8–10
Budget Pick

OTC alternative at a lower 10% concentration — effective but 5% weaker than the Encube prescription strength. Thicker, cream-gel texture that can pill slightly. Widely available without a prescription. A great starting point for those new to azelaic acid, but won't match clinical results of 15% Rx gel.

65% Match
10% Azelaic Acid Booster
~$36–38
Similar Price

OTC serum-booster with 10% azelaic acid plus salicylic acid and soothing botanicals. More cosmetically elegant with a wider ingredient deck, but at half the active concentration. Excellent for combination of exfoliation and brightening. No prescription needed, but less potent for clinical rosacea treatment.

12

Comparison with competitors

SIDE-BY-SIDE
Finacea 15% Gel Azelaic Acid
Azelaic Acid Concentration 15% (Rx Strength)
Formula Type Aqueous Gel
Ingredient Count 10 ingredients
Pregnancy Safe Yes (Category B)
FDA Approval Status FDA-Approved (Brand)
Fragrance / Allergens Free from both
Availability Rx — significantly higher cost
Texture Lightweight gel
10% Azelaic Acid Booster
Azelaic Acid Concentration 10% (OTC, weaker)
Formula Type Serum / Booster
Ingredient Count 20+ ingredients
Pregnancy Safe Check with physician
FDA Approval Status OTC cosmetic
Fragrance / Allergens Fragrance-free
Availability No prescription needed
Texture Serum — elegant feel
Azelaic Acid Suspension 10%
Azelaic Acid Concentration 10% (OTC, weaker)
Formula Type Cream-gel suspension
Ingredient Count ~15 ingredients
Pregnancy Safe Generally considered safe
FDA Approval Status OTC cosmetic
Fragrance / Allergens Fragrance-free
Availability Widely available OTC
Texture Thick — can pill on skin
13

Storage & shelf life

12 MONTHS
Period After Opening (PAO)

12 months after opening. As a pharmaceutical prescription product, check the expiry date on the carton and tube. Discard if product changes color, smell, or consistency before the PAO date.

Storage

Store at controlled room temperature 20–25°C (68–77°F). Keep away from direct sunlight, excessive heat, and moisture. Do not freeze. Keep out of reach of children. Store in the original tube and carton.

Packaging

Pharmaceutical-grade collapsible tube (50g net weight) in a protective carton. Tube packaging minimizes air and contamination exposure. Squeeze from the bottom for efficient dispensing.

Travel Friendly

Yes — the 50g tube falls under the 100ml (3.4 oz) TSA/airline carry-on liquid limit. Seal tube cap tightly before travel. Pharmaceutical prescription products may require carrying the original labeled packaging when traveling internationally.

13

Frequently asked questions

FAQ

Yes — azelaic acid 15% gel is classified as FDA Pregnancy Category B, meaning animal studies have not shown risk to the fetus and there are no adequate, well-controlled human studies indicating harm. It is one of the very few prescription actives that dermatologists feel comfortable recommending during pregnancy. Dr. Joseph Bikowski, speaking at the American Academy of Dermatology, called azelaic acid gel 15% "the one thing you can use for acne and rosacea in pregnancy where you'll never do any harm." That said, always inform your OB-GYN or midwife about any topical prescription you are using during pregnancy, as individual circumstances vary. Use only as directed by your prescribing physician.

This product contains caution-level ingredients for fungal acne sufferers. Polysorbate 80 (an oleate ester emulsifier) and Caprylic/Capric Triglyceride (a medium-chain triglyceride) are both ingredients that can potentially feed Malassezia yeast, which causes fungal acne. However, azelaic acid itself has documented antifungal and antimicrobial properties that may counteract this risk in some individuals. If you have confirmed malassezia folliculitis, we recommend consulting your dermatologist before use, starting with a patch test, and monitoring your skin closely during initial use. For confirmed fungal acne, a fully fungal-acne-safe alternative may be preferable.

Azelaic acid is one of the most compatible skincare actives available. You can generally use it alongside: Niacinamide (synergistic brightening), Vitamin C (complementary antioxidant and brightening), Hyaluronic acid (hydration layered underneath or on top), and low-concentration BHAs like salicylic acid. For retinoids (retinol, tretinoin) and stronger AHAs (glycolic, lactic acid), it's best to alternate use (morning/evening, or alternate days) rather than layering in the same application step to avoid cumulative irritation. Always apply azelaic acid gel first, allow it to dry, then layer other products on top. Start slowly and observe your skin's tolerance, especially if you have sensitive or rosacea-prone skin.

This gel is best suited for oily, acne-prone, combination, and rosacea-affected skin types. The lightweight, oil-free aqueous gel formula absorbs quickly without greasiness, making it excellent for those who dislike heavy textures. It's also well-suited for sensitive skin thanks to its clean, fragrance-free, allergen-free formulation. Dry skin types can use it but may experience more drying effects — a rich moisturizer layered immediately after the gel dries is essential. For very dry or dehydrated skin, a 20% azelaic acid cream base may provide better comfort alongside the active benefits.

Clinical trials using 15% azelaic acid gel twice daily show the following general timeline: Weeks 1–2: Skin adjustment phase — some users experience transient tingling or mild redness. Weeks 3–4: Visible reduction in active inflammatory lesions and early redness control begins. Weeks 6–8: Significant improvement in acne/rosacea, skin texture smoothes, and dark spot fading becomes noticeable. Week 12: This is the standard clinical endpoint — most patients achieve peak results. Per FDA prescribing information, if no improvement is observed after completing 12 weeks of therapy, the diagnosis should be reassessed by a healthcare provider. Results are maintained with ongoing consistent use.

Apply after cleansing and toning, before heavier serums and moisturizers. The correct layering order is: (1) Gentle cleanser → (2) Alcohol-free toner → (3) Azelaic Acid Gel 15% → (4) Lightweight serum or niacinamide → (5) Moisturizer → (6) Sunscreen (AM only). Allow the gel to fully absorb and dry before layering other products — approximately 60 seconds. For PM use, skip sunscreen and apply your regular moisturizer as the final step. Avoid using with alcoholic cleansers, astringents, abrasives, or mechanical exfoliants in the same routine step, as these can increase irritation.

No — this formulation is rated 1/5 on the comedogenic scale, making it very low-risk for pore-clogging. The formula is oil-free and water-based. Key ingredients: Azelaic acid itself is comedolytic (actively unclogs pores) and is bactericidal against acne-causing bacteria. Propylene glycol has a comedogenic rating of 0. Caprylic/Capric Triglyceride rates 0–1 on the comedogenic scale. There are no heavy oils, waxes, or high-rating emollients in this formula. In fact, the keratolytic action of azelaic acid makes this gel actively helpful for preventing and clearing clogged pores rather than contributing to them.

The period after opening (PAO) for Encube Azelaic Acid Gel 15% is 12 months. The 50g tube, used twice daily with pea-sized applications (approximately 0.5g per use), provides roughly a 50-day supply for a full-face application, or up to 3–4 months if used for targeted spot treatment. Always check the expiry date printed on the carton and tube. Store at room temperature (20–25°C) away from direct sunlight, heat, and moisture. Do not use if the product has changed color, texture, or smell from its original white-to-yellowish-white opaque gel appearance, even if within the PAO period.

— Skincarisma verdict
4.8 / 5 ★★★★★

Verdict: Encube Azelaic Acid Gel 15% is a pharmaceutical-grade powerhouse — an FDA-approved, prescription-strength treatment that delivers on every front. With just 9 clean ingredients and 15% azelaic acid (the highest clinically proven topical concentration), it treats rosacea, acne, and hyperpigmentation simultaneously while being one of the safest actives available for sensitive skin and pregnant individuals. The lightweight aqueous gel base provides superior active penetration versus cream alternatives, making every application maximally effective. Its clean, allergen-free, fragrance-free formulation sets it apart from cosmetic competitors. The only significant limitation is that it requires a prescription — but for those who have access, it represents exceptional clinical value at a fraction of the cost of the branded equivalent (Finacea). If you are looking for a dermatologist-trusted, evidence-backed azelaic acid treatment, Encube's formulation is the gold standard.

Product Overview

question
lightbulb What are Quick Product Notes?

Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.

muscle Pro Tip Alert!

Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.

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Quick Product Notes

Click on icons for more information
question
lightbulb What are Notable Effects & Ingredients?

Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging «promises» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.

We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.

muscle Pro Tip Alert!

Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.

Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you

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Notable Effects & Ingredients

brightening Brightening from 1 ingredient(s):
Azelaic Acid
wound Promotes Wound Healing from 1 ingredient(s):
Azelaic Acid
ache Ache-fighting from 1 ingredient(s):
Azelaic Acid
question
lightbulb What are Ingredients Related to Skin Type?

Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.

We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.

muscle Pro Tip Alert!

A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.

One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!

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Ingredients Related to Skin Types

Click on icons for more information
dry-skin Dry Skin
1
oily-skin Oily/Acne-Prone Skin
1
sensitive-skin Sensitive Skin
question
lightbulb What is the Ingredient Safety Breakdown?

Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.

muscle Pro Tip Alert!

EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.

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Ingredient Safety Breakdown

EWG Health Ratings
Low risk
Medium risk
High risk
Unknown risk
44% 22% 33%

Product ingredient list

Showing first 5 of 9 ingredients
EWG CIR Ingredient Name & Cosmetic Functions Notes
1 A
Azelaic Acid
Masking, Fragrance, Ph Adjuster, Buffering Agent, Buffering
brightening Brightening
ache Ache-fighting
Promotes Wound Healing
Redness
Irritation
Texture
Pores
0 Unknown
Benzoic Acid
Masking, Preservative
1 A
Caprylic/Capric Triglyceride
Solvent, Skin Conditioning, Masking, Perfuming, Emollient
0 Unknown
Carbon
1 A
Disodium EDTA
Viscosity Controlling, Chelating Agent
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