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C.R.E.A.M 2.0

C.R.E.A.M 2.0

Product Description

Product overview

Made in Various INTERNATIONAL

Regimen Lab C.R.E.A.M. 2.0 is a science-driven, high-ceramide barrier repair moisturizer powered by 2.5% pure ceramides in a clinically-backed 3:1:1:1 ratio with cholesterol and fatty acids, plus a 10-ingredient soothing complex featuring 5% panthenol, 1% bisabolol, and colloidal oat. Designed to repair compromised skin, reduce inflammation, and restore long-term hydration without fragrance, alcohol, or essential oils.

2.5% Pure Ceramides Fragrance-Free Alcohol-Free Essential Oil-Free Cruelty-Free Self-Preserving Formula Pregnancy-Safe Sensitive Skin Friendly Dermatologist-Tested
Pregnancy
Yes
Fungal Acne
No
Comedogenic
2/5
Type
Barrier Cream
Size
50ml
Use
AM & PM
Ingredients
39 INCI
Origin
Canada
Real reviews · YouTube Shorts
Why it's different

2.5% Pure Ceramides

Over 10x the concentration of typical ceramide creams, in a clinically-validated 3:1:1:1 ratio with cholesterol and fatty acids.

01

Texture & feel

SENSORY
Consistency
Light Cream
Scent
Fragrance-Free
Absorption
60 seconds
Finish
Soft Satin

2.5% Pure Ceramides

Over 10x the concentration of typical ceramide creams, in a clinically-validated 3:1:1:1 ratio with cholesterol and fatty acids.

10-Ingredient Soothing Complex

5% panthenol, 1% colloidal oat, 1% glycyrrhetinic acid, 1% bisabolol, 0.5% allantoin, plus avenanthramides A–D and ginger extract.

Advanced Hydration Stack

5% glycerin paired with 2% isosorbide dicaprylate — clinical studies show this delivers up to 3x longer hydration than glycerin alone.

Self-Preserving Formula

No traditional preservatives — natural antimicrobial properties of the actives reduce irritation potential for sensitive skin.

PPAR Activator Complex

Palmitamide MEA, hydroxystearic acid, and avenanthramides activate skin's own lipid synthesis for long-term barrier reinforcement.

Transparent Concentrations

Every key active percentage is published on the label — no proprietary blends, no marketing fluff, just scientific receipts.

02

Safety & compatibility

SAFE
Pregnancy & Breastfeeding Safe

Contains no retinoids, salicylic acid, hydroquinone, or chemical sunscreens. All ingredients are considered safe during pregnancy and lactation.

Not Fungal Acne Safe

Contains fatty acids (linoleic, linolenic, myristic, hydroxystearic), cetearyl glucoside, and laureth-7 which can feed Malassezia yeast.

Layers with All Actives

Compatible with retinol, vitamin C, niacinamide, AHAs, BHAs, and azelaic acid. Often recommended as a buffer to reduce irritation from strong actives.

Sensitive Skin Tested

Free of common irritants: fragrance, essential oils, alcohol, denatured alcohol, and known sensitizers. Designed for reactive and barrier-compromised skin.

Mildly Comedogenic Potential

Petrolatum and certain fatty alcohols may pose minor concerns for very acne-prone skin. Most users report no breakouts, but patch test first.

Cruelty-Free & Vegan

Never tested on animals. The cholesterol and ceramides are synthetically produced or plant-derived.

03

Ingredient breakdown

INGREDIENTS

Ceramides EOP + NP 2.5%Proven

The hero of C.R.E.A.M. 2.0. Two pure ceramides in a 3:1:1:1 ratio with cholesterol and fatty acids — mimicking the lipid composition of healthy skin. At 2.5% total, this is over ten times the concentration found in most drugstore ceramide creams.

  • Clinical research: Ceramides at 2.5%+ have been shown to significantly reduce transepidermal water loss in barrier-compromised skin.
  • Ratio matters: The 3:1:1:1 ceramide-to-cholesterol-to-fatty-acid balance is considered the gold standard for atopic and reactive skin.
  • Skin-identical: Ceramide NP and EOP naturally occur in the stratum corneum and bind directly into the skin's lipid matrix.
One of the highest published ceramide concentrations on the consumer market today.

Panthenol (Pro-Vitamin B5) 5%Proven

A powerhouse humectant and skin-soothing agent. At 5%, this is a treatment-level dose — far higher than the 0.5–2% typical of most moisturizers.

  • Barrier support: Panthenol stimulates fibroblast proliferation and helps the skin produce more of its own lipids.
  • Anti-inflammatory: Studies show it can reduce irritation triggered by other actives, fragrances, and chemical sunscreens.
  • Wound healing: Used clinically to support recovery after laser, micro-needling, and other procedures.

Glycerin 5%Proven

The most studied humectant in skincare. Pulls water from deeper layers of the skin and the environment to keep the surface hydrated.

  • Effective threshold: Research confirms benefits begin at 3% and scale up to 20–40% for severely dry skin.
  • Antimicrobial: At higher concentrations, glycerin contributes to the formula's self-preserving properties.
  • 2016 study: Found glycerin to be more effective than AHAs and hyaluronic acid as a humectant.

Petrolatum ~3-5%Proven

The most effective occlusive agent known to dermatology. Reduces transepidermal water loss by up to 99% — a level no plant oil can match.

  • Gold standard occlusive: Recommended by the American Academy of Dermatology for eczema, dermatitis, and barrier repair.
  • Non-comedogenic at cosmetic grades: Highly purified USP-grade petrolatum does not clog pores in most users.
  • Inert & hypoallergenic: Does not absorb into skin and has no known allergens.

Isosorbide Dicaprylate 2%Promising

A next-generation humectant from sugar beets that signals skin to produce more of its own moisturizing molecules (AQP3 and CD44).

  • Clinical study: A 2% lotion kept skin three times more hydrated than 2% glycerin in real-user testing.
  • Anti-inflammatory: In-vitro lab tests showed it calmed irritation and supported healthier skin cell renewal.
  • Long-term effect: Activates the skin's natural hydration mechanisms rather than just sitting on the surface.

Bisabolol 1%Proven

A natural soothing compound derived from chamomile. Clinically shown to reduce redness and calm inflamed skin.

  • Anti-irritant: Inhibits inflammatory cytokines (IL-1, TNF-α) that drive sensitivity flare-ups.
  • Penetration enhancer: Helps other beneficial actives reach deeper layers of the skin.
  • Suitable for rosacea: Frequently recommended for chronically reactive and red skin.

Glycyrrhetinic Acid (Licorice Root) 1%Proven

An active compound from licorice root with potent anti-inflammatory and brightening properties.

  • Cortisone-like action: Mimics topical hydrocortisone in calming flare-ups, without steroid side effects.
  • Pigmentation support: Inhibits tyrosinase to gradually fade post-inflammatory dark marks.
  • Eczema relief: Studied in atopic dermatitis treatment with positive outcomes.

Colloidal Oat & Avenanthramides 1% + extractsProven

Avena Sativa kernel flour and extract, plus standardized avenanthramides A, B, C, and D — the most potent anti-inflammatory compounds in oats.

  • FDA-recognized: Colloidal oat is approved as a skin protectant for eczema and irritation.
  • Itch relief: Avenanthramides reduce histamine-driven itching and redness.
  • Antioxidant: Avenanthramides have anti-aging benefits beyond soothing.

Allantoin 0.5%Proven

A skin protectant that promotes cell turnover and softens flaky, rough texture.

  • Keratolytic: Gently removes dead surface cells without abrasion or irritation.
  • Healing booster: Used clinically to support recovery from minor wounds and burns.

Cholesterol + Fatty Acid Complex ~5% totalProven

Linoleic acid, linolenic acid, palmitamide MEA, myristic acid, and hydroxystearic acid round out the lipid matrix alongside cholesterol.

  • Barrier-identical lipids: These match the natural fatty composition of the stratum corneum.
  • PPAR activation: Palmitamide MEA and hydroxystearic acid trigger the skin's own lipid synthesis pathways.
  • Linoleic acid benefit: Studies suggest it may help reduce comedone formation in acne-prone users.

39 ingredients

Water, Glycerin, Petrolatum, Panthenol, Pentylene Glycol, Behenyl Alcohol, Butylene Glycol, Dimethicone, Decyl Glucoside, Polysilicone-11, Isosorbide Dicaprylate, Arachidyl Alcohol, Arachidyl Glucoside, Cetearyl Alcohol, Cetearyl Glucoside, Bisabolol, Ceramide EOP, Ceramide NP, 4-T-Butylcyclohexanol, Avena Sativa (Oat) Kernel Flour, Glycyrrhetinic Acid, Allantoin, Linoleic Acid, Linolenic Acid, Palmitamide MEA, Cholesterol, Myristic Acid, Hydroxystearic Acid, Zingiber Officinale (Ginger) Root Extract, Avena Sativa (Oat) Kernel Extract, Avenanthramides, Hydroxymethoxyphenyl Decanone, Tocopherol, Lactic Acid, Polyacrylamide, C13-14 Isoparaffin, Tetrasodium Glutamate Diacetate, Laureth-7, Potassium Sorbate.

FREE FROM: Fragrance · Essential Oils · Alcohol (denat.) · Parabens · Sulfates · Silicones (other than dimethicone) · Hidden Preservatives · Mineral Oil (uses petrolatum) · Synthetic Dyes · Phthalates · Formaldehyde Releasers · Animal Testing.
04

Where it fits in your routine

ROUTINE
1
Cleanser
2
Toner
3
Treatment Serum
4
Hydrating Serum
5
C.R.E.A.M. 2.0
6
SPF (AM)

C.R.E.A.M. 2.0 is the final hydration step before SPF in the morning, or the last step of your evening routine. It locks in everything underneath while reinforcing the barrier overnight.

05

How to use

HOW TO USE
1

Cleanse & Apply Serums

Start with clean, slightly damp skin. Apply your treatment serums (vitamin C, retinol, niacinamide, etc.) and let them absorb for 30–60 seconds.

2

Dispense a Pea-Sized Amount

A small dab is enough thanks to the improved spreadability of the 2.0 formula. Use more on dry zones or for full neck and chest.

3

Press & Smooth Across Face

Warm between fingertips and press gently into the skin, then smooth outward across the face and neck. Avoid rubbing.

4

Use Twice Daily

Apply morning and night. In the AM, follow with broad-spectrum SPF 30+. For very irritated skin, brand recommends use as an in-shower moisturizer before drying off.

5

Multi-Use Tip

Excellent on chapped lips, cuticles, dry elbows, or post-procedure skin. Also doubles as an overnight slugging alternative for those who don't tolerate pure petrolatum.

06

Who is it for?

WHO

Perfect for you if:

  • You have a damaged or compromised skin barrier
  • Your skin is dry, dehydrated, flaky, or tight
  • You experience eczema, dermatitis, or chronic redness
  • You use strong actives (retinoids, AHAs, BHAs) and need a buffer
  • You have post-procedure or post-irritation skin
  • You prefer fragrance-free, science-backed formulas
  • You want one moisturizer that works AM and PM, year-round
  • You're pregnant or breastfeeding and need a safe moisturizer

Consider alternatives if:

  • You have fungal acne (Malassezia folliculitis)
  • You prefer ultra-light gels for very oily skin in humid climates
  • You dislike richer, slightly occlusive textures
  • You have a known allergy to oats or licorice extract
  • You want a tinted or anti-aging-focused moisturizer with peptides
  • You're on a tight budget and can find acceptable drugstore alternatives
07

Skin type compatibility

SKIN TYPES
Dry Skin
Excellent

Designed for this exact concern. Petrolatum, ceramides, and isosorbide dicaprylate deliver deep, long-lasting hydration.

Sensitive Skin
Excellent

Fragrance-free, alcohol-free, with a 10-ingredient soothing complex. Excellent for eczema-prone and reactive skin.

Combination
Good

Works well, though oilier zones may prefer a thinner layer. Reformulated 2.0 spreads more easily than the original.

Oily Skin
Moderate

Effective for barrier repair, but the petrolatum-rich base may feel heavy on very oily skin in summer or humid climates.

Acne-Prone
Good

Most acne sufferers tolerate it well. Linoleic acid may even help. However, not safe for fungal acne — patch test first.

Mature Skin
Excellent

High-ceramide formulas are ideal for mature skin where natural lipid production declines. Pairs beautifully with retinol.

08

Results timeline

6–8 WEEKS
Immediately

Soft, Comforted Skin

Tightness disappears within minutes. Skin feels soothed, plumper, and smoother to the touch immediately after application.

95% noticed
3–7 Days

Reduced Redness & Irritation

The 10-ingredient soothing complex calms visible inflammation. Reactive flare-ups, post-active stinging, and rough patches start to fade.

82% noticed
2–4 Weeks

Stronger Barrier & Even Tone

Transepidermal water loss decreases. Skin tolerates actives better. Texture is more uniform and breakouts heal faster without lingering marks.

76% noticed
6–8 Weeks

Long-Term Resilience

Skin maintains hydration longer between applications. Sensitivity to weather, fragrance, and acids drops noticeably. Overall skin "health score" improves.

68% noticed
09

Ratings by platform

2K+ REVIEWS
Regimen Lab (Brand Site)
4.7
Rating
2,500+
Reviews
Main complaint: 50ml size feels small for the price; some wish for a 100ml option.
SkinSort
4.8
Community Rating
123+
Routines Using
Main complaint: Not Malassezia (fungal acne) safe due to fatty acids and esters in formula.
WIMJ (What's In My Jar)
100/100
Promises Score
Low
Irritancy
Main complaint: Several fatty alcohols and esters with mild comedogenic potential noted.
Reddit (r/SkincareAddiction)
4.6
Community Sentiment
"HG"
Holy Grail Status
Main complaint: Premium price compared to drugstore ceramide creams like CeraVe.
10

Pros & cons

BALANCED

Praised

  • Industry-leading 2.5% pure ceramide concentration
  • Transparent, published percentages of all key actives
  • Repairs barrier visibly within 2–4 weeks
  • Fragrance-free and very low irritation potential
  • Excellent buffer for retinol, AHA, and BHA users
  • Self-preserving formula minimizes added preservatives
  • Comforts eczema, post-procedure, and reactive skin
  • Pregnancy and breastfeeding safe

Criticized

  • Premium price (~$44 for 50ml)
  • Not fungal acne (Malassezia) safe
  • 50ml size depletes quickly with full face + neck use
  • May feel slightly heavy on oily skin in hot weather
  • Mostly direct-to-consumer (limited retail availability)
  • International shipping costs can be high
11

Budget-friendly alternatives (dupes)

DUPES
72% Match
Moisturizing Cream
$19.99
Budget Pick

Contains the same 3 ceramides but at significantly lower concentration. Lacks the soothing complex (no panthenol at 5%, no bisabolol, no licorice). Solid barrier basics, but less specialized for compromised skin.

68% Match
Toleriane Double Repair Face Moisturizer
$22.99
Budget Pick

Includes ceramides, niacinamide, and prebiotic thermal water. Lighter texture but lower ceramide percentage. Good drugstore option for sensitive skin without the premium pricing.

82% Match
Ceramidin Ultra Moisture Cream
$48.00
Similar Price

K-beauty rival with five ceramides plus ceramide-stimulating peptides. Slightly heavier finish, more "balm-like." Better for very dry winter skin, but lacks the soothing complex depth.

65% Match
Natural Moisturizing Factors + HA
$14.50
Budget Pick

Lower-cost barrier-style moisturizer with NMF, amino acids, and HA. No active ceramide percentage disclosed; lacks soothing complex. Good entry-level option but far less repair-focused.

12

Comparison with competitors

SIDE-BY-SIDE
Moisturizing Cream
Ceramide Concentration Undisclosed (low)
Soothing Complex None
Size 340g
Fragrance None
Disclosed Percentages No
Country of Origin USA
Best For Daily basics, body use, budget
Ceramidin Ultra Moisture Cream
Ceramide Concentration 5 ceramide types (undisclosed %)
Soothing Complex Limited (panthenol, allantoin)
Size 50ml
Fragrance Light fragrance
Disclosed Percentages No
Country of Origin South Korea
Best For Very dry, mature, winter use
Triple Lipid Restore 2:4:2
Ceramide Concentration 2% (with 4% cholesterol, 2% FAs)
Soothing Complex Limited
Size 48ml
Fragrance Fragranced
Disclosed Percentages Yes
Country of Origin USA
Best For Mature, anti-aging, luxury tier
13

Storage & shelf life

12 MONTHS
Period After Opening (PAO)

12 months after opening

Storage

Store in a cool, dry place away from direct sunlight. Avoid bathroom humidity for longer shelf life.

Packaging

Airless pump tube (50ml) — minimizes air exposure and preserves active ingredient stability.

Travel Friendly

Yes — under 100ml, TSA-compliant for carry-on luggage. Pump format prevents leaks.

13

Frequently asked questions

FAQ

Yes. C.R.E.A.M. 2.0 contains no retinoids, salicylic acid, hydroquinone, or chemical sunscreen filters — the main categories that pregnant or breastfeeding individuals are advised to avoid. Its ingredients (ceramides, panthenol, glycerin, petrolatum, oat, licorice) are widely considered safe during pregnancy and lactation. As always, consult your OB-GYN or dermatologist if you have specific concerns.

No. The formula contains several ingredients that can feed Malassezia yeast: linoleic acid, linolenic acid, myristic acid, hydroxystearic acid, cetearyl glucoside, and laureth-7. If you have confirmed fungal acne (small uniform itchy bumps, often on forehead, chest, or back), this is not the ideal choice. Look for fungal-acne-safe alternatives based on glycerin, propylene glycol, and squalane instead.

Absolutely — in fact, this is one of its primary use cases. C.R.E.A.M. 2.0 is widely recommended as a buffer or finishing moisturizer to reduce irritation from retinol, tretinoin, vitamin C (ascorbic acid), glycolic acid, lactic acid, salicylic acid, and azelaic acid. Apply your active first, wait 60 seconds, then layer C.R.E.A.M. 2.0 on top to lock in benefits and minimize stinging or peeling.

It performs best on dry, dehydrated, sensitive, and barrier-compromised skin. Mature skin and eczema-prone skin also benefit greatly. Combination skin tolerates it well year-round. Oily skin can use it in winter or as a night cream, but may find it slightly heavy in summer or humid climates. Acne-prone (non-fungal) users typically tolerate it without breakouts due to its low comedogenic profile.

Comfort and softness are immediate. Visible reduction in redness and irritation typically shows within 3–7 days. Stronger, more resilient barrier function (less reactivity, fewer flare-ups, better tolerance to actives) develops over 2–4 weeks of consistent twice-daily use. Long-term skin "health" benefits — including improved tone, texture, and reduced sensitivity to weather — are reported around 6–8 weeks.

It is the final hydration step, applied after cleanser, toner, and any treatment or hydrating serums — but before SPF in the morning. In the evening, it is typically the last step. The brand also recommends it as an in-shower moisturizer for severely irritated skin, applied to damp skin before towel drying.

It carries a moderate-low comedogenic rating of approximately 2/5. Petrolatum and certain fatty alcohols (cetearyl alcohol, behenyl alcohol) have theoretical pore-clogging potential, but in practice the vast majority of acne-prone users report no breakouts. Linoleic acid in the formula may even support clearer pores. If you are highly comedogenic-reactive, patch test on the jawline for 2 weeks before full-face use.

The Period After Opening (PAO) is 12 months. The airless pump packaging helps preserve the formula by limiting air and contamination exposure, but for optimal performance use within one year of opening. Store away from direct sunlight and high heat. Despite being a "self-preserving" formula, hygiene practices (clean hands, no double-dipping) help extend shelf life.

— Skincarisma verdict
4.7 / 5 ★★★★★

Verdict: Regimen Lab C.R.E.A.M. 2.0 sits in a small group of moisturizers that genuinely deliver on the "barrier repair" promise — and back it up with disclosed percentages, peer-reviewed actives, and a 10-ingredient soothing complex you'd typically only find in a dedicated treatment serum. With 2.5% pure ceramides (over 10x most drugstore competitors), 5% panthenol, and clinically-validated isosorbide dicaprylate, it punches well above its $44 price tag for science-driven users dealing with sensitivity, dryness, eczema, or post-active irritation. The trade-offs are real — it is not fungal-acne safe, the 50ml size depletes quickly, and oily skin in summer may want something lighter. But for anyone serious about repairing a compromised barrier without fragrance, alcohol, or marketing fluff, this is one of the most thoughtfully formulated moisturizers on the market today.

Product Overview

question
lightbulb What are Quick Product Notes?

Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.

muscle Pro Tip Alert!

Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.

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Quick Product Notes

Click on icons for more information
question
lightbulb What are Notable Effects & Ingredients?

Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging «promises» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.

We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.

muscle Pro Tip Alert!

Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.

Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you

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Notable Effects & Ingredients

anti-aging Anti-Aging from 3 ingredient(s):
Ceramide NP Tocopherol Lactic Acid
brightening Brightening from 2 ingredient(s):
Glycerin Lactic Acid
wound Promotes Wound Healing from 6 ingredient(s):
Glycerin Panthenol Allantoin Linoleic Acid Zingiber Officinale Root Extract Tocopherol
question
lightbulb What are Ingredients Related to Skin Type?

Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.

We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.

muscle Pro Tip Alert!

A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.

One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!

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Ingredients Related to Skin Types

Click on icons for more information
dry-skin Dry Skin
4
oily-skin Oily/Acne-Prone Skin
1
sensitive-skin Sensitive Skin
1
question
lightbulb What is the Ingredient Safety Breakdown?

Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.

muscle Pro Tip Alert!

EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.

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Ingredient Safety Breakdown

EWG Health Ratings
Low risk
Medium risk
High risk
Unknown risk
51% 10% 38%

Product ingredient list

Showing first 5 of 39 ingredients
EWG CIR Ingredient Name & Cosmetic Functions Notes
2 A
Glycerin
Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant, Skin Conditioning
brightening Brightening
Promotes Wound Healing
Hydrating
4 Unknown
Petrolatum
Emollient, Hair Conditioning, Skin Protecting, Uv Absorber, Moisturising, Skin-Conditioning Agent - Occlusive
1 A
Panthenol
Skin Conditioning, Antistatic Agent, Hair Conditioning
Promotes Wound Healing
Hydrating
Redness
Irritation
1 A
Pentylene Glycol
Solvent, Skin Conditioning
1 A
Behenyl Alcohol
Emollient, Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Binding Agent, Binding
VIEW ALL INGREDIENTS