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Cicabio Crème+

Cicabio Crème+

Product Description

Product overview

Made in France FRENCH BEAUTY

An ultra-repairing soothing cream that accelerates skin recovery from day one. Powered by Antalgicine™ technology and Optimal Repair complex, Cicabio Crème+ deeply restores damaged, irritated, and fragile skin on face, body, and intimate areas while relieving discomfort and itching.

Fragrance-Free Paraben-Free Hypoallergenic Dermatologically Tested Pediatric Tested Gynecologically Tested Non-Comedogenic Silicone-Free Alcohol-Free
Pregnancy
Yes
Fungal Acne
No
Comedogenic
1/5
Size
40ml / 100ml
Type
Repair Cream
Concern
Damaged Skin
pH Level
Physiological
Age
From Birth
Real reviews · YouTube Shorts
Why it's different

Antalgicine™ Technology

Exclusive biomimetic peptide (Acetyl Dipeptide-1 Cetyl Ester) that reduces discomfort sensations and itching, preventing scratching that disrupts healing.

01

Texture & feel

SENSORY
Consistency
Rich cream
Scent
Fragrance-free
Absorption
1–2 minutes
Finish
Semi-matte film

Antalgicine™ Technology

Exclusive biomimetic peptide (Acetyl Dipeptide-1 Cetyl Ester) that reduces discomfort sensations and itching, preventing scratching that disrupts healing.

Optimal Repair Complex

Proprietary blend of Xylose, Fructooligosaccharides, and Rhamnose that promotes skin repair at all levels: epidermis, dermal-epidermal junction, and dermis.

Microbiome-Centric Formula

Restores cutaneous microbiome diversity in just 3 hours with biomimetic lipids, physiological pH, and no antibacterial agents.

Protective Healing Texture

Creates a breathable, plaster-like film that shields damaged skin from external aggressors while facilitating scar massage.

02

Safety & compatibility

SAFE
Pregnancy & Breastfeeding Safe

Free from retinoids, salicylic acid, hydroquinone, and chemical UV filters. All ingredients are considered safe during pregnancy and breastfeeding.

Not Fungal Acne (Malassezia) Safe

Contains Caprylic/Capric Triglyceride, Rapeseed Seed Oil, Hydrogenated Rapeseed Oil, and Sunflower Seed Oil which can feed malassezia yeast.

Low Comedogenic Risk (1/5)

Non-comedogenic formula with squalane (0), jojoba oil (2), and glycerin (0). Clinically tested not to clog pores.

Safe for Babies (From Birth)

Pediatrically tested and suitable for newborns (except premature infants). Can be used on diaper area and around the mouth.

Post-Procedure Safe

Ideal after chemical peels, laser treatments, microneedling, waxing, and tattoo aftercare. Gynecologically tested for intimate areas.

Usage Precautions

Do not apply to open or oozing wounds. Avoid eye contour area. For children under 36 months, consult a healthcare professional. Does not contain sunscreen — apply SPF separately.

03

Ingredient breakdown

INGREDIENTS

Acetyl Dipeptide-1 Cetyl Ester (Antalgicine™) ~0.15–0.30%Proven

Bioderma's patented biomimetic peptide that mimics the body's own mechanisms to reduce discomfort sensations, itching, and the urge to scratch — allowing the skin to heal undisturbed.

  • Clinical Data: -88% reduction in discomfort and itching in Bioderma's clinical studies
  • Mechanism: Modulates skin nerve signals to calm reactivity at the source
  • Benefit: Prevents scratching-induced damage that can worsen scarring

Sodium HyaluronateProven

The salt form of hyaluronic acid, a naturally occurring molecule in skin. Provides deep hydration by attracting and retaining water in the upper skin layers, supporting optimal conditions for skin repair.

  • Function: Holds up to 1,000x its weight in water for intense moisture
  • Role in formula: Maintains hydration levels essential during the skin repair process

SqualaneProven

A plant-derived, biomimetic lipid that closely resembles the skin's own sebum. Restores the lipid barrier without feeling greasy, providing emollient protection and locking in moisture.

  • Comedogenic rating: 0 — will not clog pores
  • Benefit: Strengthens the skin's natural barrier and supports microbiome restoration

Sodium PolyglutamatePromising

A next-generation humectant derived from fermented soybeans. Delivers superior hydration compared to traditional humectants and enhances the skin's natural moisturizing factor (NMF).

  • Research: Studies suggest it can inhibit hyaluronidase, helping the skin retain more of its own hyaluronic acid
  • Benefit: Creates a moisture-retaining film on the skin surface

Fructooligosaccharides + Rhamnose + Xylitol + MannitolProven

Bioderma's Optimal Repair complex — a synergistic blend of sugars and sugar derivatives that work at multiple levels to accelerate epidermal repair, strengthen the dermal-epidermal junction, and support collagen production in the dermis.

  • Clinical Data: +88% skin repair acceleration from day 1
  • Mechanism: Fructooligosaccharides act as prebiotics for the skin microbiome; Rhamnose stimulates cell renewal; Xylose boosts glycosaminoglycan synthesis

Tocopherol (Vitamin E)Proven

A potent fat-soluble antioxidant that protects skin cells from free radical damage and supports the healing process. Also acts as a natural preservative in the formula.

  • Benefit: Protects fragile, repairing skin from oxidative stress
  • Source: Derived from Sunflower Seed Oil in this formula

28 ingredients

Aqua/Water/Eau, Caprylic/Capric Triglyceride, Glycerin, Polyglyceryl-3 Polyricinoleate, Brassica Campestris (Rapeseed) Seed Oil, Butylene Glycol, Tapioca Starch, Hydrogenated Rapeseed Oil, Xylose, Polyglyceryl-3 Diisostearate, Simmondsia Chinensis (Jojoba) Seed Oil, Magnesium Sulfate, Pentylene Glycol, Squalane, 1,2-Hexanediol, Caprylyl Glycol, Sodium Polyglutamate, Sodium Citrate, Xanthan Gum, Sodium Hyaluronate, Tocopherol, Mannitol, Rhamnose, Xylitol, Acetyl Dipeptide-1 Cetyl Ester, Helianthus Annuus (Sunflower) Seed Oil, Citric Acid, Fructooligosaccharides.

FREE FROM: Fragrance, Parabens, Silicones, Alcohol, Sulfates, Mineral Oil, Colorants, Common Allergens, Gluten, Coconut derivatives, Petroleum-based ingredients, Drying alcohols
04

Where it fits in your routine

ROUTINE
1
Cleanser
2
Toner
3
Serum
4
Cicabio Crème+
5
Moisturizer
6
Sunscreen

Apply as a treatment cream after cleansing. Can replace your moisturizer on damaged areas. When used on the full face, skip additional moisturizer. Always follow with sunscreen during the day.

05

How to use

HOW TO USE
1

Cleanse Gently

Clean the damaged area with a mild cleanser (Bioderma recommends Cicabio Baume lavant). Pat dry thoroughly before application.

2

Apply Generously

Apply a thick layer of Cicabio Crème+ directly to the affected area. Can be used on face, body, lips, and intimate areas.

3

Massage for Scars (Optional)

For scar care: use flat hand massage along the scar direction, then fingertip circular motions, then palpate-and-roll technique to soften tissue.

4

Repeat Twice Daily

Use morning and evening until the skin is fully repaired. Apply sunscreen over it during the day, as this product does not contain UV protection.

06

Who is it for?

WHO

Perfect for you if:

  • You have irritated, chapped, or damaged skin needing repair
  • You're recovering from a dermatological procedure (laser, peel, microneedling)
  • You need post-surgical scar care (caesarean section, episiotomy)
  • You want a baby-safe product for diaper rash or dry patches
  • You use tretinoin/retinol and experience peeling or irritation
  • You need a fragrance-free, multi-use healing cream for the whole family

Consider alternatives if:

  • You have fungal acne (malassezia) — this formula contains trigger ingredients
  • You need a lightweight, non-occlusive daytime moisturizer
  • You prefer a product with built-in sun protection
  • You want an active treatment cream (retinol, acids) rather than a repair cream
  • You have open, oozing wounds — wait until the wound closes first
07

Skin type compatibility

SKIN TYPES
Dry Skin
Excellent

Rich, nourishing formula with squalane, jojoba oil, and rapeseed oil provides deep repair and lasting hydration for compromised dry skin.

Sensitive Skin
Excellent

Hypoallergenic, fragrance-free, and dermatologically tested. Antalgicine™ actively calms discomfort and itching sensations.

Normal Skin
Good

Effective as a targeted treatment for damaged areas. May feel too rich for daily full-face use on healthy normal skin.

Oily Skin
Moderate

Rich texture may feel heavy on oily skin types. Best used as a targeted spot treatment rather than an all-over moisturizer. Can leave a slightly sticky film.

Combination Skin
Good

Works well on dry, damaged patches. Apply only to affected areas to avoid excess oiliness in the T-zone.

Acne-Prone Skin
Good

Non-comedogenic and clinically tested. Safe for acne-prone skin, but not suitable for fungal acne. Use as targeted treatment on irritated areas.

08

Results timeline

4–6 WEEKS
Immediately

Instant Comfort & Protection

The cream forms a protective, breathable film over damaged skin. Antalgicine™ begins reducing sensations of discomfort and itching immediately upon application.

88% felt reduced discomfort
3 Hours

Microbiome Restoration

Clinical studies show that the cutaneous microbiome diversity (Shannon index) is restored within 3 hours after application compared to untreated disinfected skin.

Clinically measured
Day 1–3

Visible Skin Repair Begins

Accelerated epidermal repair is measurable from day 1. By day 3, dermatologist-scored improvement is visible with reduced redness and smoother texture on treated areas.

+88% skin repair from day 1
1–2 Weeks

Significant Healing Progress

Skin barrier is substantially restored. Minor cuts, abrasions, and post-procedure skin show major improvement. Scars become softer and flatter with consistent scar massage technique.

75% reported visible improvement
4–6 Weeks

Complete Skin Recovery

Full repair for most skin damage types. Continued use for scar care can further improve the appearance, texture, and flexibility of scar tissue over time.

90% satisfaction rate
09

Ratings by platform

1K+ REVIEWS
Amazon
4.4
Rating
850+
Reviews
Main complaint: Sticky texture that doesn't layer well under other products or makeup
iHerb
4.3
Rating
120+
Reviews
Main complaint: Heavy texture not suitable for oily skin; small tube size for the price
Influenster
4.8
Rating
40+
Reviews
Main complaint: Tube packaging requires firm squeezing when product is running low
MakeupAlley
4.2
Rating
30+
Reviews
Main complaint: New Crème+ formula is greasier than original; concerns about product authenticity on some platforms
10

Pros & cons

BALANCED

Praised

  • Clinically proven to accelerate skin repair from day 1 (+88%)
  • Antalgicine™ effectively relieves itching and discomfort immediately
  • Versatile: safe for face, body, lips, intimate areas, and babies
  • Fragrance-free, hypoallergenic, and dermatologically tested
  • Restores skin microbiome in just 3 hours
  • Non-comedogenic — won't clog pores despite rich texture
  • Excellent post-procedure recovery (laser, peels, microneedling)
  • Clean ingredient list with only 28 ingredients, no common irritants

Criticized

  • Sticky, occlusive texture that doesn't layer well under other products or makeup
  • Not fungal acne safe due to plant oils and fatty acid esters
  • Small 40ml tube can run out quickly with full-body use
  • No built-in sun protection — requires additional sunscreen
  • Rich formula may feel too heavy for oily skin types
  • New Crème+ formula is greasier than the discontinued original
  • Beige tint from natural ingredients may be visible on very pale skin
11

Budget-friendly alternatives (dupes)

DUPES
85% Match
Cicaplast Baume B5+
$15.99
Budget Pick

The closest alternative with similar repair focus. Uses panthenol (5%) + madecassoside instead of Antalgicine™. Slightly more moisturizing with shea butter, widely available, and often less expensive per ml. More popular globally.

75% Match
Cicalfate+ Restorative Protective Cream
$20.00
Similar Price

Uses sucralfate + Avène Thermal Spring Water + C+-Restore postbiotic complex. Thicker, more occlusive texture. Better for heavily damaged skin but less moisturizing. Contains zinc oxide for mineral UV protection and antibacterial effect.

65% Match
A-Derma Epitheliale A.H Ultra Repairing Cream
$18.00
Similar Price

Another French pharmacy repair cream using Rhealba Oat extract + hyaluronic acid. Lighter texture than Cicabio Crème+ but less comprehensive repair complex. Good option for those who find Cicabio too rich.

12

Comparison with competitors

SIDE-BY-SIDE
Cicaplast Baume B5+
Key Active Panthenol 5% + Madecassoside
Size 40ml / 100ml
Texture Baume, creamy-thick
Fragrance None
Pregnancy Safe Yes
Fungal Acne Safe No
Baby Safe Yes
Unique Strength High panthenol dose + shea butter hydration
Cicalfate+ Restorative Protective Cream
Key Active Sucralfate + C+-Restore + Thermal Water
Size 40ml / 100ml
Texture Thick, very occlusive
Fragrance None
Pregnancy Safe Yes
Fungal Acne Safe No
Baby Safe Yes
Unique Strength Medical-grade sucralfate + postbiotic technology

A-Derma Epitheliale A.H Ultra

Key Active Rhealba Oat + Hyaluronic Acid
Size 40ml / 100ml
Texture Light cream, non-sticky
Fragrance None
Pregnancy Safe Yes
Fungal Acne Safe Check formula
Baby Safe Yes
Unique Strength Lightest texture among repair creams
13

Storage & shelf life

6 MONTHS
Period After Opening (PAO)

6 months after opening

Storage

Store in a cool, dry place below 25°C (77°F). Keep away from direct sunlight and heat sources.

Packaging

Squeeze tube with screw cap. Hygienic dispensing minimizes contamination risk.

Travel Friendly

Yes — 40ml tube is under the 100ml carry-on liquid limit. Compact size fits easily in travel bags.

13

Frequently asked questions

FAQ

Yes. Cicabio Crème+ does not contain retinoids, salicylic acid, hydroquinone, chemical sunscreens, or any other ingredients flagged as unsafe during pregnancy or breastfeeding. The formula is built on gentle plant oils (rapeseed, jojoba, sunflower), squalane, glycerin, and biocompatible repair peptides. It is safe to use on the body, including post-caesarean scars and around the breast area (wash off before nursing). Always consult your healthcare provider if you have specific concerns.

No. Cicabio Crème+ is not fungal acne safe. It contains several ingredients that can feed malassezia yeast, including Caprylic/Capric Triglyceride, Brassica Campestris (Rapeseed) Seed Oil, Hydrogenated Rapeseed Oil, Simmondsia Chinensis (Jojoba) Seed Oil, and Helianthus Annuus (Sunflower) Seed Oil. If you are prone to fungal acne, look for an alternative repair cream without oils and fatty acid esters.

Yes — in fact, Cicabio Crème+ is an excellent companion to active ingredients. Many users apply it after retinol or tretinoin to buffer irritation and prevent peeling. You can also layer it over areas treated with vitamin C, AHAs, or BHAs. However, avoid mixing it directly with strong actives on freshly damaged or broken skin. If using actives, apply them first, wait for absorption, then apply Cicabio Crème+ as a soothing, protective layer.

Cicabio Crème+ works best for dry, sensitive, and damaged skin types. Its rich, nourishing formula with squalane, jojoba oil, and rapeseed oil provides deep repair and lasting hydration. It is dermatologically, pediatrically, and gynecologically tested for maximum compatibility. Oily skin types can still benefit but should use it as a targeted treatment on damaged areas rather than an all-over moisturizer, as the texture can feel heavy and leave a film.

Results are rapid. Clinical studies show +88% skin repair from day 1, with microbiome restoration in just 3 hours. Most users report immediate soothing and comfort upon first application. Visible skin improvement (reduced redness, smoother texture) is typically seen within 1–3 days. Full skin repair for minor damage takes 1–2 weeks. For scar care, consistent use with massage technique for 4–6 weeks or longer yields the best results.

Apply Cicabio Crème+ after cleansing and any serums or treatments, in the moisturizer/treatment step of your routine. On damaged areas, it can replace your regular moisturizer entirely. During the day, always follow with a separate sunscreen, as Cicabio Crème+ does not contain UV protection. At night, it can be your final skincare step, applied in a thick layer for intensive overnight repair.

Cicabio Crème+ is clinically tested as non-comedogenic, with a comedogenic rating of approximately 1 out of 5. Its key emollients — squalane (comedogenic rating 0) and jojoba oil (rating 2) — are among the least pore-clogging oils available. Despite its rich texture, it has been clinically validated not to clog pores. However, individual skin reactions vary, so if you are highly acne-prone, consider patch testing first.

Cicabio Crème+ has a Period After Opening (PAO) of 6 months. After opening, use the product within 6 months for optimal efficacy and safety. The squeeze tube packaging helps minimize contamination from air and fingers. Store in a cool, dry place below 25°C and away from direct sunlight. The 40ml tube typically lasts 4–6 weeks with twice-daily face application, while the 100ml tube is more economical for body use.

— Skincarisma verdict
4.3 / 5 ★★★★☆

Verdict: Bioderma Cicabio Crème+ is a highly effective, clinically-backed repair cream from one of France's most trusted dermo-cosmetic brands. Its unique Antalgicine™ technology sets it apart from competitors by actively reducing discomfort and itching — something Cicaplast and Cicalfate cannot match. The reformulated Crème+ version adds microbiome-centric benefits with proven 3-hour microbiome restoration. It excels for post-procedure recovery, scar care, baby skin, and any situation where damaged skin needs gentle yet powerful repair. The main drawbacks are its sticky texture (which can be tricky to layer), the fact that it is not fungal acne safe, and its relatively short 6-month PAO. For everyday use on healthy skin, competitors like Cicaplast offer lighter textures. But for serious skin repair needs, Cicabio Crème+ delivers science-backed results that justify its place in any medicine cabinet.

Product Overview

question
lightbulb What are Quick Product Notes?

Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.

muscle Pro Tip Alert!

Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.

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Quick Product Notes

Click on icons for more information
question
lightbulb What are Notable Effects & Ingredients?

Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging «promises» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.

We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.

muscle Pro Tip Alert!

Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.

Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you

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Notable Effects & Ingredients

anti-aging Anti-Aging from 3 ingredient(s):
Tocopherol Acetyl Dipeptide-1 Cetyl Ester Citric Acid
brightening Brightening from 2 ingredient(s):
Glycerin Citric Acid
wound Promotes Wound Healing from 5 ingredient(s):
Glycerin Simmondsia Chinensis Seed Oil Sodium Hyaluronate Tocopherol Citric Acid
question
lightbulb What are Ingredients Related to Skin Type?

Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.

We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.

muscle Pro Tip Alert!

A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.

One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!

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Ingredients Related to Skin Types

Click on icons for more information
dry-skin Dry Skin
4
oily-skin Oily/Acne-Prone Skin
1
sensitive-skin Sensitive Skin
question
lightbulb What is the Ingredient Safety Breakdown?

Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.

muscle Pro Tip Alert!

EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.

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Ingredient Safety Breakdown

EWG Health Ratings
Low risk
Medium risk
High risk
Unknown risk
66% 33%

Product ingredient list

Showing first 5 of 27 ingredients
EWG CIR Ingredient Name & Cosmetic Functions Notes
1 Unknown
Water
Solvent, Skin Conditioning
1 A
Caprylic/Capric Triglyceride
Solvent, Skin Conditioning, Masking, Perfuming, Emollient
2 A
Glycerin
Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant, Skin Conditioning
brightening Brightening
Promotes Wound Healing
Hydrating
0 Unknown
Polyglyceryl-3 Polyricinoleate
Emulsifying
1 A
Butylene Glycol
Solvent, Skin Conditioning, Masking, Fragrance, Humectant, Viscosity Controlling, Viscositydecreasing Agent
Hydrating
VIEW ALL INGREDIENTS