Cicalfate+ Repairing Protective Cream
Cicalfate+ Repairing Protective Cream
Product Description
Product overview
A rich, nourishing multi-purpose repair cream formulated with postbiotic C+-Restore technology to restore damaged skin barriers in 48 hours. Clinically proven with 45 uses from cuts and scrapes to post-procedure care. Safe for infants, children, and adults.
Postbiotic C+-Restore Technology
Patented ingredient derived from Aquaphilus Dolomiae bacterium found in Avène Thermal Spring Water. Supports microbiome and accelerates skin repair.
Texture & feel
SENSORYPostbiotic C+-Restore Technology
Patented ingredient derived from Aquaphilus Dolomiae bacterium found in Avène Thermal Spring Water. Supports microbiome and accelerates skin repair.
Antibacterial Protection
Copper and Zinc Sulfates work together to limit bacterial proliferation while promoting healing. Clinically tested for wound care.
Avène Thermal Spring Water
Rich in minerals and trace elements. Backed by 150+ studies proving soothing, softening, and anti-inflammatory properties.
Safe for Whole Family
Clinically tested under dermatological, pediatric, and gynecological control. Safe for infants, children, and adults including sensitive intimate areas.
Safety & compatibility
SAFEConfirmed safe by Avène. No retinoids, salicylic acid, or harmful ingredients. Dermatologist-recommended during pregnancy for dry, irritated skin.
Safe to use while nursing. Can be applied to cracked nipples (wipe before feeding). No harmful substances that could transfer to baby.
Contains Polyglyceryl-2 Sesquiisostearate, beeswax, and arginine which can feed Malassezia yeast. Avoid if prone to fungal acne.
Accepted by the National Eczema Association (NEA). Formulated to minimize allergic reactions. Ideal for atopic skin conditions.
Recommended by dermatologists after laser treatments, chemical peels, microneedling, and minor surgical procedures.
Rich, occlusive texture may feel heavy on oily skin. Best used at night or as a spot treatment rather than full-face daily moisturizer.
Ingredient breakdown
INGREDIENTSC+-Restore (Aquaphilus Dolomiae Ferment Filtrate)Proven
Patented postbiotic ingredient derived from a unique bacterium found exclusively in Avène Thermal Spring Water. This breakthrough technology supports the skin microbiome and accelerates the natural repair process.
- Clinical Study: Restored skin barrier 4x faster than untreated skin in controlled trials
- Mechanism: Rich in proteins that promote epidermal regeneration
- Research: Tested in 150+ clinical studies including oncology patients
Copper & Zinc Sulfates ComplexProven
Dual-action antibacterial complex that helps limit bacterial proliferation on damaged skin while supporting the healing process. Long-established in wound care medicine.
- Copper Sulfate: Antimicrobial properties, reduces infection risk
- Zinc Sulfate: Promotes wound healing, reduces inflammation
- Synergy: Combined effect provides purifying protection during repair
Avène Thermal Spring Water 45%+Proven
Natural mineral water sourced from the Cévennes Mountains in France. Rich in silicates, trace elements, and has a unique mineral composition that soothes and calms irritated skin.
- 150+ Studies: Proven soothing, softening, and anti-irritating properties
- Mineral Balance: Low mineral content with optimal Ca/Mg ratio
- History: Used therapeutically since 1736 for skin conditions
Zinc OxideProven
Physical barrier-forming mineral with broad-spectrum protective properties. Creates an occlusive shield that protects healing skin from external aggressors while allowing the skin to breathe.
- Barrier Function: Creates protective layer on damaged skin
- Anti-inflammatory: Reduces redness and irritation
- UV Protection: Provides incidental mineral sun protection
GlycerinProven
Gold-standard humectant that draws moisture into the skin and helps maintain optimal hydration levels. Essential for supporting the skin barrier repair process.
- Hydration: Attracts and retains water in the epidermis
- Barrier Support: Maintains skin lipids in healthy state
- Tolerance: Effective and well-tolerated at various concentrations
18 ingredients
Water (Avène Thermal Spring Water), Caprylic/Capric Triglyceride, Mineral Oil (Paraffinum Liquidum), Glycerin, Hydrogenated Vegetable Oil, Zinc Oxide, Propylene Glycol, Polyglyceryl-2 Sesquiisostearate, PEG-22/Dodecyl Glycol Copolymer, Aluminum Stearate, Aquaphilus Dolomiae Ferment Filtrate, Arginine, Beeswax (Cire d'Abeille), Copper Sulfate, Magnesium Stearate, Microcrystalline Wax, Tromethamine, Zinc Sulfate
Where it fits in your routine
ROUTINEApply as final step in PM routine or over retinoids. For daytime, follow with sunscreen. Can replace moisturizer for damaged/compromised skin.
How to use
HOW TO USECleanse Thoroughly
Start with clean, dry skin. For extra soothing, mist with Avène Thermal Spring Water beforehand and pat dry.
Apply Thin Layer
Dispense a pea-sized amount and gently massage into affected areas. A little goes a long way due to the rich texture.
Allow Absorption
Wait 2-3 minutes for the cream to absorb. The protective film you feel is intentional for barrier protection.
Apply Twice Daily
Use morning and evening for best results. Continue until skin is fully restored, typically 7-21 days depending on concern.
Who is it for?
WHOPerfect for you if:
- You have a damaged or compromised skin barrier
- You're recovering from dermatological procedures
- You experience eczema, rosacea, or chronic dryness
- You use retinoids and need barrier support
- You need a multi-purpose healing product for the whole family
- You want a pregnancy-safe repair cream
- You have cuts, scrapes, or minor burns
- You need post-tattoo or post-waxing care
Consider alternatives if:
- You have fungal acne (malassezia folliculitis)
- You prefer lightweight, fast-absorbing textures
- You have very oily skin and want daytime use
- You dislike mineral oil in your skincare
- You need a mattifying moisturizer
- You're looking for anti-aging benefits
Skin type compatibility
SKIN TYPESRich, occlusive formula provides intense nourishment and locks in moisture. Perfect as a daily moisturizer for chronically dry skin.
Hypoallergenic, fragrance-free formula. NEA accepted. Formulated specifically for ultra-sensitive and reactive skin types.
Best used as a night treatment or targeted on dry patches. May feel too rich for T-zone during the day.
Too heavy for full-face daily use. Best as occasional repair treatment or for specific concerns. Use sparingly at night.
Non-comedogenic claim. Good for healing post-acne irritation but avoid if you have fungal acne. Use as spot treatment.
Results timeline
2-3 WEEKSInstant Soothing & Comfort
Skin feels immediately calmed, protected, and comfortable. The rich texture creates a noticeable protective barrier on application.
95% noticed soothing effectVisible Barrier Restoration
Clinical studies show skin barrier restoration begins. Redness and irritation significantly reduced. Damaged skin shows improvement.
Clinically proven restorationSignificant Healing Progress
Minor cuts, scrapes, and irritations well on their way to healing. Post-procedure redness substantially diminished.
85% reported healingComplete Recovery
Most skin concerns fully resolved. Barrier function restored. Skin texture improved. Scarring minimized with continued use.
91% satisfied with resultsRatings by platform
12K+ REVIEWSPros & cons
BALANCEDPraised
- Exceptional healing for damaged skin barriers
- Multi-purpose: 45 clinical indications
- Safe for whole family including infants
- Fragrance-free, hypoallergenic formula
- NEA accepted for eczema-prone skin
- Works brilliantly after retinoid use
- Clinically proven postbiotic technology
- Great for post-procedure recovery
- Pregnancy and breastfeeding safe
Criticized
- Heavy texture not suitable for oily skin
- Can separate in extreme temperatures
- Not fungal acne safe
- Contains mineral oil (concern for some)
- Takes time to fully absorb
- Higher price point than drugstore options
- May feel greasy under makeup
- 40ml tube runs out quickly with daily use
Budget-friendly alternatives (dupes)
DUPESUses panthenol and madecassoside instead of postbiotic. Lighter texture, absorbs faster. Contains shea butter for extra moisture. Better for oily skin types.
Petrolatum-based ointment formula. More occlusive but lacks antibacterial benefits and postbiotic technology. Better for pure occlusion needs.
Contains ceramides and hyaluronic acid. Good barrier support but lacks the antibacterial copper-zinc complex and thermal water benefits.
Ultra-simple formula for sensitive skin. Free from dyes, fragrance, and common irritants but lacks active healing ingredients.
Comparison with competitors
SIDE-BY-SIDEAvène Cicalfate+ (Featured)
Storage & shelf life
6 MONTHS6 months after opening. Note the date you first open the tube for optimal efficacy.
Store below 25°C (77°F) in a cool, dry place. Avoid freezing - temperatures below 0°C may cause formula separation.
Metal-lined tube with screw cap. Protects formula from air and light oxidation. Squeeze from bottom for best dispensing.
Yes - 40ml is under TSA 100ml limit. Metal tube is durable for travel. Keep in temperature-controlled carry-on.
Frequently asked questions
FAQYes, Avène Cicalfate+ is safe during pregnancy and breastfeeding. According to Avène's official FAQ, it is specifically listed as safe to use during these periods. The formula contains no retinoids, salicylic acid, hydroquinone, or other ingredients of concern during pregnancy. Many dermatologists recommend it for dry, irritated pregnancy skin. It can even be used on cracked nipples during breastfeeding (wipe clean before nursing).
No, Avène Cicalfate+ is NOT fungal acne safe. The formula contains several ingredients that can feed Malassezia yeast, including Polyglyceryl-2 Sesquiisostearate (an ester), Beeswax, and Arginine (in the presence of lipids). If you're prone to fungal acne or pityrosporum folliculitis, consider La Roche-Posay Cicaplast Gel B5 as an alternative, though even that should be patch-tested.
Yes! Cicalfate+ is actually ideal for buffering the irritation from active ingredients. Apply your retinol, vitamin C, or exfoliating acids first, wait 10-15 minutes, then apply Cicalfate+ as an occlusive final layer. This "retinoid sandwich" method helps minimize irritation while allowing actives to work. The cream's barrier-repairing properties are perfect for counteracting the dryness and sensitivity caused by potent treatments.
Cicalfate+ is best suited for dry, sensitive, and compromised skin types. It's excellent for those with eczema, rosacea, or dermatitis. The rich, occlusive texture provides maximum protection for damaged barriers. However, if you have oily skin, it may feel too heavy for full-face daily use - in that case, use it as a nighttime treatment or targeted spot treatment. Combination skin types can use it on dry patches only.
You'll feel immediate soothing and comfort upon first application. Clinical studies show visible barrier restoration within 48 hours of consistent use. For minor cuts, scrapes, or irritations, expect significant improvement within 1 week. Full healing for more serious concerns (post-procedure, deeper damage) typically occurs within 2-3 weeks with twice-daily application. Scar appearance may continue improving with extended use.
Apply Cicalfate+ as your last skincare step (before sunscreen in AM). The typical order is: Cleanser → Toner → Serum → Treatment → Cicalfate+. Its rich, occlusive texture is designed to seal in previous products and create a protective barrier. In the morning, always follow with sunscreen. At night, it can be your final step, acting as an overnight healing mask.
Avène Cicalfate+ is officially labeled non-comedogenic and has a low comedogenic rating of 1/5. However, individual responses vary. The formula contains mineral oil and beeswax which some people find pore-clogging. If you're acne-prone, start with spot testing and use as a targeted treatment rather than all-over moisturizer. Many acne-prone users successfully use it to heal post-acne irritation without breakouts.
Cicalfate+ has a PAO (Period After Opening) of 6 months. The product should be used within 6 months of first opening for optimal efficacy. The 40ml tube typically lasts 6-8 weeks with twice-daily facial use, while the 100ml tube can last 3-4 months. Store below 25°C and avoid freezing, as extreme temperatures can cause formula separation. If the product separates, it's still safe but may be less effective.
Verdict: Avène Cicalfate+ is a gold-standard repair cream backed by serious science. The patented C+-Restore postbiotic technology sets it apart from generic healing ointments, and the antibacterial copper-zinc complex provides genuine clinical benefit. It's the perfect medicine cabinet essential for everything from retinoid recovery to minor wounds. The only drawbacks are its heavy texture (not for oily skin) and lack of fungal acne safety. For damaged barriers, post-procedure care, or anyone needing serious skin repair, it delivers on its promises. A French pharmacy hero that lives up to the hype.
Product Overview
Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.
Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.
Quick Product Notes
Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging «promises» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.
We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.
Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.
Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you
Notable Effects & Ingredients
Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.
We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.
A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.
One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!
Ingredients Related to Skin Types
Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.
EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.
Ingredient Safety Breakdown
Product ingredient list
| EWG | CIR | Ingredient Name & Cosmetic Functions | Notes |
|---|---|---|---|
| 1 |
Caprylic/Capric Triglyceride
Solvent, Skin Conditioning, Masking, Perfuming, Emollient
|
|
|
| 0 |
Paraffinum Liquidum
Emollient, Skin Protecting, Solvent
|
|
|
| 2 |
Glycerin
Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant, Skin Conditioning
|
Promotes Wound Healing
Hydrating
|
|
| 1 |
Hydrogenated Vegetable Oil
Skin Conditioning, Emollient, Viscosity Increasing Agent
|
Hydrating
|
|
| 2 |
Zinc Oxide
Skin Protecting, Sunscreen Agent, Cosmetic Colorant
|
UV Protection
|





