Clindamycin Phosphate Topical Lotion 1%
Clindamycin Phosphate Topical Lotion 1%
Product Description
Product overview
A prescription-strength topical antibiotic lotion that delivers 1% clindamycin phosphate directly to acne-affected skin. This moisturizing lotion formulation kills acne-causing bacteria (C. acnes), reduces inflammation, and helps clear mild to moderate inflammatory acne without the harshness of alcohol-based solutions.
Kills Acne Bacteria
Clindamycin inhibits bacterial protein synthesis by binding to 23S RNA of the 50S ribosomal subunit, effectively stopping C. acnes growth and reproduction.
Texture & feel
SENSORYKills Acne Bacteria
Clindamycin inhibits bacterial protein synthesis by binding to 23S RNA of the 50S ribosomal subunit, effectively stopping C. acnes growth and reproduction.
Anti-Inflammatory Action
Reduces free fatty acid concentration in sebum from approximately 14% down to 2%, helping calm redness and swelling associated with inflammatory acne lesions.
Moisturizing Lotion Base
Unlike alcohol-based solutions, this lotion contains glycerin and emollients that hydrate while treating, making it ideal for those with dry or sensitive skin.
Minimal Systemic Absorption
Topical application results in very low serum levels (0–3 ng/mL) with less than 0.2% of the dose recovered systemically, reducing risk of internal side effects.
Safety & compatibility
SAFEFDA formerly Category B. Studies in pregnant women during 2nd/3rd trimester show no increased birth defect risk. However, no adequate first-trimester studies exist. Topical use results in minimal systemic absorption. Consult your doctor before use during pregnancy.
Topical application has minimal absorption and is unlikely to affect breast milk. However, avoid applying to the chest area to prevent accidental infant ingestion. Oral/IV clindamycin does appear in breast milk.
Contains cetostearyl alcohol, stearic acid, and isostearyl alcohol — fatty acids and alcohols that can feed Malassezia yeast. Clindamycin itself is inactive against fungi. Not suitable for pityrosporum folliculitis.
Contains cetostearyl alcohol and isostearyl alcohol which have a mild comedogenic potential, but overall the formulation is well-tolerated by most skin types. Patch test recommended for acne-prone skin.
Long-term use of clindamycin alone can promote antibiotic-resistant bacteria. Dermatologists recommend pairing with benzoyl peroxide to reduce resistance risk. Limit treatment courses to 12 weeks when possible.
Topical clindamycin can be absorbed systemically. In rare cases, it may cause diarrhea or pseudomembranous colitis. Discontinue and consult a doctor if severe diarrhea develops.
Free from the top 11 most common allergens as determined by Mayo Clinic research. Fragrance-free, propylene glycol-free (lotion form), nickel-free, and gluten-free.
This is a prescription medication (Rx only). It must be prescribed by a licensed healthcare provider such as a dermatologist or physician. Not available over the counter.
Ingredient breakdown
INGREDIENTSClindamycin Phosphate 1%Proven
A water-soluble ester prodrug that converts to active clindamycin in the skin. It inhibits bacterial protein synthesis and is bacteriostatic against Cutibacterium acnes (formerly P. acnes). Also reduces free fatty acid levels in sebum and may inhibit leukocyte chemotaxis to reduce inflammation.
- Mechanism: Binds to 23S RNA of the 50S ribosomal subunit, halting bacterial protein production
- Efficacy: Clinical studies show significant reduction in inflammatory acne lesions after 8–12 weeks of twice-daily application
- Sebum Effect: Reduces free fatty acids on skin surface from ~14% to ~2%
- Absorption: Serum levels of 0–3 ng/mL after topical application; less than 0.2% recovered in urine
GlycerinProven
A powerful humectant that draws water into the skin barrier. Helps counteract potential dryness from the antibiotic treatment and keeps the skin hydrated and supple throughout the day.
- Function: Humectant and skin-conditioning agent that strengthens the moisture barrier
- Benefit: Prevents the dryness and flaking commonly associated with topical acne treatments
Cetostearyl Alcohol 2.5%Emollient
A mixture of cetyl and stearyl alcohol used as an emollient and emulsifier. Gives the lotion its smooth, creamy texture and helps stabilize the formulation. Despite the name, it is a fatty alcohol (not a drying alcohol) and is generally well-tolerated.
- Function: Emollient, emulsifier, and texture enhancer
- Safety: FDA recognizes fatty alcohols as non-irritating; products with fatty alcohols can still be labeled "alcohol-free"
Methylparaben 0.3%Preservative
A preservative that prevents microbial growth in the product. Used at a low concentration of 0.3% to ensure product stability and safety throughout its shelf life.
- Function: Antimicrobial preservative to prevent bacterial and fungal contamination
- Safety: Widely used in pharmaceuticals and cosmetics at concentrations up to 0.4%; considered safe by FDA and CIR
Sodium Lauroyl SarcosinateSurfactant
A mild amino acid-based surfactant derived from sarcosine. Acts as a gentle cleansing and conditioning agent in the formulation, helping the lotion spread evenly on the skin without stripping natural oils.
- Function: Mild surfactant and skin-conditioning agent
- Benefit: Gentler alternative to SLS/SLES; suitable for sensitive skin formulations
10 ingredients
Clindamycin Phosphate (1%), Cetostearyl Alcohol (2.5%), Glycerin, Glyceryl Stearate SE (with Potassium Monostearate), Isostearyl Alcohol (2.5%), Methylparaben (0.3%), Sodium Lauroyl Sarcosinate, Stearic Acid, Purified Water
Where it fits in your routine
ROUTINEApply twice daily (AM & PM) after cleansing. Wait 1–2 minutes before layering moisturizer. In the morning, always finish with sunscreen. If using benzoyl peroxide, apply at a different time of day to avoid irritation.
How to use
HOW TO USEShake Well
Shake the bottle well immediately before each use. The lotion is a suspension and ingredients can separate if left standing.
Cleanse & Dry
Wash the affected area with a mild, non-comedogenic cleanser. Gently pat skin completely dry with a clean towel.
Apply a Thin Film
Apply a thin layer of the lotion to all acne-affected areas — not just individual pimples. Cover the entire zone prone to breakouts (face, chest, or back as prescribed).
Let It Absorb
Allow 1–2 minutes for the lotion to absorb before applying moisturizer, sunscreen, or makeup. Wash hands after application. Avoid contact with eyes, nose, and mouth.
Who is it for?
WHOPerfect for you if:
- You have mild to moderate inflammatory acne (papules, pustules)
- You prefer a moisturizing lotion over harsh alcohol-based solutions
- Your dermatologist has prescribed a topical antibiotic
- You experience hormonal acne flare-ups (jawline, chin, cheeks)
- You want an acne treatment that does not cause purging
- You have dry or sensitive skin that reacts to harsher acne treatments
Consider alternatives if:
- You have fungal acne (Malassezia folliculitis) — this product can worsen it
- You primarily have non-inflammatory acne (blackheads, whiteheads only)
- You have a history of colitis, C. difficile, or GI sensitivity to antibiotics
- You are allergic to clindamycin or lincomycin
- You want an over-the-counter solution (this requires a prescription)
- You have severe nodular/cystic acne that may need oral medication
Skin type compatibility
SKIN TYPESEffectively targets acne-causing bacteria common in oily skin. Lotion base may feel slightly emollient; some users report a dewy finish. Pair with oil-free moisturizer.
The moisturizing lotion base with glycerin and emollients is ideal for dry skin. Much gentler than alcohol-based clindamycin solutions or gels.
Balances well across different face zones. Hydrating enough for dry areas while not overly heavy for the T-zone.
Fragrance-free, alcohol-free lotion form is the gentlest clindamycin vehicle available. Top allergen free per SkinSAFE rating. Ideal for reactive skin.
Directly targets inflammatory acne bacteria. Comedogenic rating of 2/5 — low risk but not zero. Best combined with benzoyl peroxide for optimal results and resistance prevention.
Results timeline
WEEKS 8–12Early Inflammation Reduction
Active pimples may begin to decrease in redness and swelling. Some users report overnight reduction of cystic swelling within the first few applications. No purging effect since this is an antibiotic, not a retinoid.
30% noticed improvementVisible Clearing Begins
Noticeable decline in new breakouts. Existing inflammatory lesions shrink and begin healing. Skin texture starts improving. Oil production on the skin surface begins to normalize.
55% noticed improvementSignificant Improvement
Substantial reduction in both the number and severity of acne lesions. Post-inflammatory redness begins fading. Skin tone appears more even and smoother overall.
75% noticed improvementFull Treatment Course Results
Maximum therapeutic benefit typically achieved. Clinical studies show significant reduction in inflammatory lesion counts. Discuss with your dermatologist whether to continue, switch, or add complementary treatments.
85% noticed improvementRatings by platform
400+ REVIEWSPros & cons
BALANCEDPraised
- Fast-acting — many users see improvement within the first week
- Moisturizing lotion base is gentler than gel or solution forms
- Fragrance-free and top allergen free formulation
- Does not cause purging like retinoids
- Effective against inflammatory and cystic acne
- Can be used during pregnancy with doctor approval (Category B)
- Minimal systemic absorption when applied topically
- Works well in combination with benzoyl peroxide and retinoids
Criticized
- Requires a prescription — not available over the counter
- Lotion can feel greasy or oily on already oily skin
- Risk of antibiotic resistance with prolonged solo use
- Not effective for non-inflammatory acne (blackheads/whiteheads)
- Not fungal acne safe due to fatty alcohol content
- Small 60 mL bottle may not last long with full-face application
- Rare but serious risk of pseudomembranous colitis
- Acne may return after discontinuing treatment
Budget-friendly alternatives (dupes)
DUPESNearly identical formulation from a different generic manufacturer (Israel-based Padagis). Same active ingredient at 1%, same lotion vehicle with cetearyl alcohol and glycerin. Used in 35+ routines on SkinSort.
Another generic clindamycin lotion from India-based Encube. Same 1% concentration in a lotion base. Very similar inactive ingredients. Used in 269 routines on SkinSort. May be more affordable depending on pharmacy.
Same 1% clindamycin in a gel base instead of lotion. Better for oily skin as it is lighter and less emollient. Contains allantoin for soothing. However, contains propylene glycol which the lotion form avoids.
Comparison with competitors
SIDE-BY-SIDEBenzaClin (Clindamycin 1% + BP 5%)
Storage & shelf life
3 MONTHSUse within 3 months of opening or as directed by your pharmacist. Check expiration date on bottle. Prescription medications have specific expiry dates printed on the label.
Store at controlled room temperature 20°–25°C (68°–77°F). Protect from freezing. Keep container tightly closed. Keep out of reach of children.
60 mL plastic squeeze bottle. Shake well before each use as this is a suspension formula. Keep tightly closed when not in use.
Yes — 60 mL is under the 100 mL TSA/airline liquid limit. Keep at room temperature during travel and protect from extreme heat or freezing.
Frequently asked questions
FAQTopical clindamycin was formerly classified as FDA Pregnancy Category B, meaning animal studies showed no fetal harm and there are limited human studies. Systemic studies during the 2nd and 3rd trimesters have not shown increased birth defect risk. Topical use results in minimal systemic absorption (less than 0.2%). However, no adequate first-trimester studies exist, so use only if clearly needed and prescribed by your doctor. For breastfeeding, topical application is unlikely to reach breast milk in significant amounts, but avoid applying to the chest area. Always consult your healthcare provider.
No, this product is NOT fungal acne safe. The lotion formulation contains cetostearyl alcohol (2.5%), isostearyl alcohol (2.5%), stearic acid, and glyceryl stearate — all of which are fatty acids/alcohols that can feed Malassezia yeast and worsen pityrosporum folliculitis. Additionally, clindamycin itself is an antibacterial agent that is inactive against fungi. If you suspect fungal acne, consult your dermatologist for appropriate antifungal treatments instead. The clindamycin solution form (alcohol-based) may be a better alternative as it lacks these fatty ingredients.
Yes, clindamycin can generally be combined with other actives, but timing matters. It pairs especially well with tretinoin (retinoids) — in fact, combination products like Ziana exist for this purpose. You can use retinol or tretinoin at night and clindamycin in the morning, or vice versa. With AHA/BHA, apply them at different times to avoid irritation. Vitamin C (ascorbic acid) can be used in the same routine but apply it first, wait a few minutes, then apply clindamycin. The most important pairing is with benzoyl peroxide to prevent antibiotic resistance — use BP at a different time of day.
The lotion form is best suited for dry, sensitive, and combination skin types. Its moisturizing base with glycerin and emollients provides hydration while treating acne — making it the gentlest clindamycin vehicle available. Those with very oily skin may find the lotion too emollient and prefer the gel or solution forms instead. It is ideal for anyone who experienced dryness, burning, or irritation from alcohol-based clindamycin solutions.
Many users notice initial improvement within the first 1–2 weeks, particularly reduced redness and swelling of active pimples. Significant clearing typically occurs between weeks 4–8 of consistent twice-daily use. Full treatment benefit is usually achieved by 8–12 weeks. However, if your acne has not improved after 6 weeks or gets worse, consult your dermatologist. Do not stop using the medication early just because symptoms improve — completing the treatment course helps prevent recurrence.
Apply after cleansing and toning, but before moisturizer and sunscreen. The typical order is: (1) Gentle cleanser, (2) Toner (optional), (3) Clindamycin lotion (thin film to affected areas), (4) Wait 1–2 minutes, (5) Moisturizer, (6) Sunscreen (AM only). Apply twice daily, morning and evening, as prescribed. If using benzoyl peroxide, use it at the opposite time of day to minimize irritation while still preventing antibiotic resistance.
The comedogenic rating is approximately 2 out of 5 — a low to moderate risk. The formulation contains cetostearyl alcohol and isostearyl alcohol (each at 2.5%) which have mild pore-clogging potential. However, most users tolerate the lotion well without increased breakouts. The lotion actually helps reduce comedone-causing free fatty acids in sebum. If you are extremely acne-prone or have experienced breakouts from fatty alcohol-containing products before, the gel or solution form may be preferable.
As a prescription pharmaceutical, the product should be used according to the expiration date printed on the bottle/label by your pharmacy — typically within 12 months of dispensing. Once opened, use as directed by your pharmacist. Store at room temperature (20°–25°C / 68°–77°F), protect from freezing, and keep the container tightly closed. Shake well before each use as the formula is a suspension. Discard any medication that appears discolored, has an unusual odor, or has passed its expiration date.
Verdict: Greenstone Clindamycin Phosphate Topical Lotion 1% is a dermatologist-trusted, FDA-approved prescription antibiotic for mild to moderate inflammatory acne. Its moisturizing lotion base sets it apart from harsher gel and solution formulations, making it the top choice for those with dry, sensitive, or combination skin. It works quickly — often within the first week — by directly targeting acne-causing bacteria while reducing inflammation. However, it is not suitable for fungal acne, must be paired with benzoyl peroxide to prevent resistance, and requires a prescription. For the right candidate, it is a highly effective and well-tolerated cornerstone of a comprehensive acne treatment regimen.
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Product Overview
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Quick Product Notes
Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging «promises» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.
We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.
Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.
Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you
Notable Effects & Ingredients
Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.
We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.
A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.
One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!
Ingredients Related to Skin Types
Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.
EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.
Ingredient Safety Breakdown
Product ingredient list
| EWG | CIR | Ingredient Name & Cosmetic Functions | Notes |
|---|---|---|---|
| 2 |
Glycerin
Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant, Skin Conditioning
|
Promotes Wound Healing
Hydrating
|
|
| 1 |
Glyceryl Stearate
Emollient, Emulsifying
|
|
|
| 0 |
Clindamycin Phosphate
|
|
|
| 1 |
Stearic Acid
Masking, Fragrance, Emulsion Stabilising, Emulsifying, Sufactant, Refatting, Cleansing
|
|
|
| 0 |
Isostearyl Alcohol
Emollient, Skin Conditioning
|
|




