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Clindamycin Phosphate Topical Lotion 1%

Clindamycin Phosphate Topical Lotion 1%

Product Description

Product overview

Made in Various INTERNATIONAL

A prescription-strength topical antibiotic lotion that delivers 1% clindamycin phosphate directly to acne-affected skin. This moisturizing lotion formulation kills acne-causing bacteria (C. acnes), reduces inflammation, and helps clear mild to moderate inflammatory acne without the harshness of alcohol-based solutions.

Prescription Antibiotic Fragrance-Free Dermatologist Prescribed FDA-Approved for Acne Alcohol-Free (Lotion Form) SkinSAFE Top Allergen Free
Pregnancy
Caution
Fungal Acne
No
Comedogenic
2/5
Type
Rx Antibiotic
Size
60 mL
Concern
Acne Vulgaris
Usage
Twice Daily
Brand
Greenstone
Real reviews · YouTube Shorts
Why it's different

Kills Acne Bacteria

Clindamycin inhibits bacterial protein synthesis by binding to 23S RNA of the 50S ribosomal subunit, effectively stopping C. acnes growth and reproduction.

01

Texture & feel

SENSORY
Consistency
Thin lotion
Scent
Fragrance-free
Absorption
1–2 minutes
Finish
Slightly dewy

Kills Acne Bacteria

Clindamycin inhibits bacterial protein synthesis by binding to 23S RNA of the 50S ribosomal subunit, effectively stopping C. acnes growth and reproduction.

Anti-Inflammatory Action

Reduces free fatty acid concentration in sebum from approximately 14% down to 2%, helping calm redness and swelling associated with inflammatory acne lesions.

Moisturizing Lotion Base

Unlike alcohol-based solutions, this lotion contains glycerin and emollients that hydrate while treating, making it ideal for those with dry or sensitive skin.

Minimal Systemic Absorption

Topical application results in very low serum levels (0–3 ng/mL) with less than 0.2% of the dose recovered systemically, reducing risk of internal side effects.

02

Safety & compatibility

SAFE
Pregnancy: Use with Caution

FDA formerly Category B. Studies in pregnant women during 2nd/3rd trimester show no increased birth defect risk. However, no adequate first-trimester studies exist. Topical use results in minimal systemic absorption. Consult your doctor before use during pregnancy.

Breastfeeding: Use with Caution

Topical application has minimal absorption and is unlikely to affect breast milk. However, avoid applying to the chest area to prevent accidental infant ingestion. Oral/IV clindamycin does appear in breast milk.

Not Fungal Acne (Malassezia) Safe

Contains cetostearyl alcohol, stearic acid, and isostearyl alcohol — fatty acids and alcohols that can feed Malassezia yeast. Clindamycin itself is inactive against fungi. Not suitable for pityrosporum folliculitis.

Low Comedogenic Risk (2/5)

Contains cetostearyl alcohol and isostearyl alcohol which have a mild comedogenic potential, but overall the formulation is well-tolerated by most skin types. Patch test recommended for acne-prone skin.

Antibiotic Resistance Risk

Long-term use of clindamycin alone can promote antibiotic-resistant bacteria. Dermatologists recommend pairing with benzoyl peroxide to reduce resistance risk. Limit treatment courses to 12 weeks when possible.

GI Side Effect Risk

Topical clindamycin can be absorbed systemically. In rare cases, it may cause diarrhea or pseudomembranous colitis. Discontinue and consult a doctor if severe diarrhea develops.

Top Allergen Free

Free from the top 11 most common allergens as determined by Mayo Clinic research. Fragrance-free, propylene glycol-free (lotion form), nickel-free, and gluten-free.

Prescription Required

This is a prescription medication (Rx only). It must be prescribed by a licensed healthcare provider such as a dermatologist or physician. Not available over the counter.

03

Ingredient breakdown

INGREDIENTS

Clindamycin Phosphate 1%Proven

A water-soluble ester prodrug that converts to active clindamycin in the skin. It inhibits bacterial protein synthesis and is bacteriostatic against Cutibacterium acnes (formerly P. acnes). Also reduces free fatty acid levels in sebum and may inhibit leukocyte chemotaxis to reduce inflammation.

  • Mechanism: Binds to 23S RNA of the 50S ribosomal subunit, halting bacterial protein production
  • Efficacy: Clinical studies show significant reduction in inflammatory acne lesions after 8–12 weeks of twice-daily application
  • Sebum Effect: Reduces free fatty acids on skin surface from ~14% to ~2%
  • Absorption: Serum levels of 0–3 ng/mL after topical application; less than 0.2% recovered in urine
Do not use clindamycin as monotherapy long-term. Pair with benzoyl peroxide to minimize antibiotic resistance. Discontinue if severe diarrhea occurs.

GlycerinProven

A powerful humectant that draws water into the skin barrier. Helps counteract potential dryness from the antibiotic treatment and keeps the skin hydrated and supple throughout the day.

  • Function: Humectant and skin-conditioning agent that strengthens the moisture barrier
  • Benefit: Prevents the dryness and flaking commonly associated with topical acne treatments

Cetostearyl Alcohol 2.5%Emollient

A mixture of cetyl and stearyl alcohol used as an emollient and emulsifier. Gives the lotion its smooth, creamy texture and helps stabilize the formulation. Despite the name, it is a fatty alcohol (not a drying alcohol) and is generally well-tolerated.

  • Function: Emollient, emulsifier, and texture enhancer
  • Safety: FDA recognizes fatty alcohols as non-irritating; products with fatty alcohols can still be labeled "alcohol-free"
May not be suitable for fungal acne (Malassezia folliculitis) as fatty alcohols can feed Malassezia yeast.

Methylparaben 0.3%Preservative

A preservative that prevents microbial growth in the product. Used at a low concentration of 0.3% to ensure product stability and safety throughout its shelf life.

  • Function: Antimicrobial preservative to prevent bacterial and fungal contamination
  • Safety: Widely used in pharmaceuticals and cosmetics at concentrations up to 0.4%; considered safe by FDA and CIR

Sodium Lauroyl SarcosinateSurfactant

A mild amino acid-based surfactant derived from sarcosine. Acts as a gentle cleansing and conditioning agent in the formulation, helping the lotion spread evenly on the skin without stripping natural oils.

  • Function: Mild surfactant and skin-conditioning agent
  • Benefit: Gentler alternative to SLS/SLES; suitable for sensitive skin formulations

10 ingredients

Clindamycin Phosphate (1%), Cetostearyl Alcohol (2.5%), Glycerin, Glyceryl Stearate SE (with Potassium Monostearate), Isostearyl Alcohol (2.5%), Methylparaben (0.3%), Sodium Lauroyl Sarcosinate, Stearic Acid, Purified Water

FREE FROM: Fragrance, Propylene Glycol, Parabens (except Methylparaben), SLS/SLES, Gluten, Nickel, Coconut derivatives, Lanolin, Dyes, Formaldehyde, Phthalates, Alcohol (ethanol/isopropyl), Retinoids, Benzoyl Peroxide
04

Where it fits in your routine

ROUTINE
1
Cleanser
2
Toner
3
Clindamycin Lotion
4
Moisturizer
5
Sunscreen (AM)

Apply twice daily (AM & PM) after cleansing. Wait 1–2 minutes before layering moisturizer. In the morning, always finish with sunscreen. If using benzoyl peroxide, apply at a different time of day to avoid irritation.

05

How to use

HOW TO USE
1

Shake Well

Shake the bottle well immediately before each use. The lotion is a suspension and ingredients can separate if left standing.

2

Cleanse & Dry

Wash the affected area with a mild, non-comedogenic cleanser. Gently pat skin completely dry with a clean towel.

3

Apply a Thin Film

Apply a thin layer of the lotion to all acne-affected areas — not just individual pimples. Cover the entire zone prone to breakouts (face, chest, or back as prescribed).

4

Let It Absorb

Allow 1–2 minutes for the lotion to absorb before applying moisturizer, sunscreen, or makeup. Wash hands after application. Avoid contact with eyes, nose, and mouth.

06

Who is it for?

WHO

Perfect for you if:

  • You have mild to moderate inflammatory acne (papules, pustules)
  • You prefer a moisturizing lotion over harsh alcohol-based solutions
  • Your dermatologist has prescribed a topical antibiotic
  • You experience hormonal acne flare-ups (jawline, chin, cheeks)
  • You want an acne treatment that does not cause purging
  • You have dry or sensitive skin that reacts to harsher acne treatments

Consider alternatives if:

  • You have fungal acne (Malassezia folliculitis) — this product can worsen it
  • You primarily have non-inflammatory acne (blackheads, whiteheads only)
  • You have a history of colitis, C. difficile, or GI sensitivity to antibiotics
  • You are allergic to clindamycin or lincomycin
  • You want an over-the-counter solution (this requires a prescription)
  • You have severe nodular/cystic acne that may need oral medication
07

Skin type compatibility

SKIN TYPES
Oily Skin
Good

Effectively targets acne-causing bacteria common in oily skin. Lotion base may feel slightly emollient; some users report a dewy finish. Pair with oil-free moisturizer.

Dry Skin
Excellent

The moisturizing lotion base with glycerin and emollients is ideal for dry skin. Much gentler than alcohol-based clindamycin solutions or gels.

Combination Skin
Excellent

Balances well across different face zones. Hydrating enough for dry areas while not overly heavy for the T-zone.

Sensitive Skin
Excellent

Fragrance-free, alcohol-free lotion form is the gentlest clindamycin vehicle available. Top allergen free per SkinSAFE rating. Ideal for reactive skin.

Acne-Prone Skin
Good

Directly targets inflammatory acne bacteria. Comedogenic rating of 2/5 — low risk but not zero. Best combined with benzoyl peroxide for optimal results and resistance prevention.

08

Results timeline

WEEKS 8–12
Days 1–7

Early Inflammation Reduction

Active pimples may begin to decrease in redness and swelling. Some users report overnight reduction of cystic swelling within the first few applications. No purging effect since this is an antibiotic, not a retinoid.

30% noticed improvement
Weeks 2–4

Visible Clearing Begins

Noticeable decline in new breakouts. Existing inflammatory lesions shrink and begin healing. Skin texture starts improving. Oil production on the skin surface begins to normalize.

55% noticed improvement
Weeks 4–8

Significant Improvement

Substantial reduction in both the number and severity of acne lesions. Post-inflammatory redness begins fading. Skin tone appears more even and smoother overall.

75% noticed improvement
Weeks 8–12

Full Treatment Course Results

Maximum therapeutic benefit typically achieved. Clinical studies show significant reduction in inflammatory lesion counts. Discuss with your dermatologist whether to continue, switch, or add complementary treatments.

85% noticed improvement
09

Ratings by platform

400+ REVIEWS
Drugs.com
7.4/10
Rating
150+
Reviews
Main complaint: Some users report skin getting worse initially or becoming overly greasy/oily with the lotion form
WebMD
3.7/5
Rating
200+
Reviews
Main complaint: Rare but serious reports of GI issues (diarrhea); some experience allergic rash or burning sensation
Acne.org
3.2/5
Rating
50+
Reviews
Main complaint: Lotion form may feel too greasy for oily skin types; some report it worsened their breakouts
SkinSort
Popular
Community
912
Routines
Main concern: Contains fatty alcohols and stearic acid that may trigger fungal acne or worsen oily skin
10

Pros & cons

BALANCED

Praised

  • Fast-acting — many users see improvement within the first week
  • Moisturizing lotion base is gentler than gel or solution forms
  • Fragrance-free and top allergen free formulation
  • Does not cause purging like retinoids
  • Effective against inflammatory and cystic acne
  • Can be used during pregnancy with doctor approval (Category B)
  • Minimal systemic absorption when applied topically
  • Works well in combination with benzoyl peroxide and retinoids

Criticized

  • Requires a prescription — not available over the counter
  • Lotion can feel greasy or oily on already oily skin
  • Risk of antibiotic resistance with prolonged solo use
  • Not effective for non-inflammatory acne (blackheads/whiteheads)
  • Not fungal acne safe due to fatty alcohol content
  • Small 60 mL bottle may not last long with full-face application
  • Rare but serious risk of pseudomembranous colitis
  • Acne may return after discontinuing treatment
11

Budget-friendly alternatives (dupes)

DUPES
90% Match
Clindamycin Phosphate Topical Lotion 1%
$15–$30
Generic Alternative

Nearly identical formulation from a different generic manufacturer (Israel-based Padagis). Same active ingredient at 1%, same lotion vehicle with cetearyl alcohol and glycerin. Used in 35+ routines on SkinSort.

70% Match
Clindamycin Phosphate Topical Lotion 1%
$10–$25
Budget Pick

Another generic clindamycin lotion from India-based Encube. Same 1% concentration in a lotion base. Very similar inactive ingredients. Used in 269 routines on SkinSort. May be more affordable depending on pharmacy.

65% Match
Clindamycin Phosphate Topical Gel 1% (Generic)
$15–$40
Different Vehicle

Same 1% clindamycin in a gel base instead of lotion. Better for oily skin as it is lighter and less emollient. Contains allantoin for soothing. However, contains propylene glycol which the lotion form avoids.

12

Comparison with competitors

SIDE-BY-SIDE
Clindamycin Phosphate Gel USP 1%
Active Ingredient Clindamycin 1%
Vehicle Clear Gel
Size 30–60g
Alcohol-Free Yes
Fragrance-Free Yes
Rx Required Yes
Fungal Acne Safe No
Active Ingredient Clindamycin 1%
Vehicle Alcohol Solution
Size 30–60 mL
Alcohol-Free No (50% isopropyl)
Fragrance-Free Yes
Rx Required Yes
Fungal Acne Safe Yes

BenzaClin (Clindamycin 1% + BP 5%)

Active Ingredient Clindamycin 1% + Benzoyl Peroxide 5%
Vehicle Gel
Size 25–50g
Alcohol-Free Yes
Fragrance-Free Yes
Rx Required Yes
Fungal Acne Safe Varies
13

Storage & shelf life

3 MONTHS
Period After Opening (PAO)

Use within 3 months of opening or as directed by your pharmacist. Check expiration date on bottle. Prescription medications have specific expiry dates printed on the label.

Storage

Store at controlled room temperature 20°–25°C (68°–77°F). Protect from freezing. Keep container tightly closed. Keep out of reach of children.

Packaging

60 mL plastic squeeze bottle. Shake well before each use as this is a suspension formula. Keep tightly closed when not in use.

Travel Friendly

Yes — 60 mL is under the 100 mL TSA/airline liquid limit. Keep at room temperature during travel and protect from extreme heat or freezing.

13

Frequently asked questions

FAQ

Topical clindamycin was formerly classified as FDA Pregnancy Category B, meaning animal studies showed no fetal harm and there are limited human studies. Systemic studies during the 2nd and 3rd trimesters have not shown increased birth defect risk. Topical use results in minimal systemic absorption (less than 0.2%). However, no adequate first-trimester studies exist, so use only if clearly needed and prescribed by your doctor. For breastfeeding, topical application is unlikely to reach breast milk in significant amounts, but avoid applying to the chest area. Always consult your healthcare provider.

No, this product is NOT fungal acne safe. The lotion formulation contains cetostearyl alcohol (2.5%), isostearyl alcohol (2.5%), stearic acid, and glyceryl stearate — all of which are fatty acids/alcohols that can feed Malassezia yeast and worsen pityrosporum folliculitis. Additionally, clindamycin itself is an antibacterial agent that is inactive against fungi. If you suspect fungal acne, consult your dermatologist for appropriate antifungal treatments instead. The clindamycin solution form (alcohol-based) may be a better alternative as it lacks these fatty ingredients.

Yes, clindamycin can generally be combined with other actives, but timing matters. It pairs especially well with tretinoin (retinoids) — in fact, combination products like Ziana exist for this purpose. You can use retinol or tretinoin at night and clindamycin in the morning, or vice versa. With AHA/BHA, apply them at different times to avoid irritation. Vitamin C (ascorbic acid) can be used in the same routine but apply it first, wait a few minutes, then apply clindamycin. The most important pairing is with benzoyl peroxide to prevent antibiotic resistance — use BP at a different time of day.

The lotion form is best suited for dry, sensitive, and combination skin types. Its moisturizing base with glycerin and emollients provides hydration while treating acne — making it the gentlest clindamycin vehicle available. Those with very oily skin may find the lotion too emollient and prefer the gel or solution forms instead. It is ideal for anyone who experienced dryness, burning, or irritation from alcohol-based clindamycin solutions.

Many users notice initial improvement within the first 1–2 weeks, particularly reduced redness and swelling of active pimples. Significant clearing typically occurs between weeks 4–8 of consistent twice-daily use. Full treatment benefit is usually achieved by 8–12 weeks. However, if your acne has not improved after 6 weeks or gets worse, consult your dermatologist. Do not stop using the medication early just because symptoms improve — completing the treatment course helps prevent recurrence.

Apply after cleansing and toning, but before moisturizer and sunscreen. The typical order is: (1) Gentle cleanser, (2) Toner (optional), (3) Clindamycin lotion (thin film to affected areas), (4) Wait 1–2 minutes, (5) Moisturizer, (6) Sunscreen (AM only). Apply twice daily, morning and evening, as prescribed. If using benzoyl peroxide, use it at the opposite time of day to minimize irritation while still preventing antibiotic resistance.

The comedogenic rating is approximately 2 out of 5 — a low to moderate risk. The formulation contains cetostearyl alcohol and isostearyl alcohol (each at 2.5%) which have mild pore-clogging potential. However, most users tolerate the lotion well without increased breakouts. The lotion actually helps reduce comedone-causing free fatty acids in sebum. If you are extremely acne-prone or have experienced breakouts from fatty alcohol-containing products before, the gel or solution form may be preferable.

As a prescription pharmaceutical, the product should be used according to the expiration date printed on the bottle/label by your pharmacy — typically within 12 months of dispensing. Once opened, use as directed by your pharmacist. Store at room temperature (20°–25°C / 68°–77°F), protect from freezing, and keep the container tightly closed. Shake well before each use as the formula is a suspension. Discard any medication that appears discolored, has an unusual odor, or has passed its expiration date.

— Skincarisma verdict
4.0 / 5 ★★★★☆

Verdict: Greenstone Clindamycin Phosphate Topical Lotion 1% is a dermatologist-trusted, FDA-approved prescription antibiotic for mild to moderate inflammatory acne. Its moisturizing lotion base sets it apart from harsher gel and solution formulations, making it the top choice for those with dry, sensitive, or combination skin. It works quickly — often within the first week — by directly targeting acne-causing bacteria while reducing inflammation. However, it is not suitable for fungal acne, must be paired with benzoyl peroxide to prevent resistance, and requires a prescription. For the right candidate, it is a highly effective and well-tolerated cornerstone of a comprehensive acne treatment regimen.

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Product Overview

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lightbulb What are Quick Product Notes?

Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.

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Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.

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Quick Product Notes

Click on icons for more information
question
lightbulb What are Notable Effects & Ingredients?

Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging «promises» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.

We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.

muscle Pro Tip Alert!

Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.

Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you

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Notable Effects & Ingredients

brightening Brightening from 1 ingredient(s):
Glycerin
wound Promotes Wound Healing from 1 ingredient(s):
Glycerin
ache Ache-fighting from 1 ingredient(s):
Clindamycin Phosphate
question
lightbulb What are Ingredients Related to Skin Type?

Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.

We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.

muscle Pro Tip Alert!

A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.

One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!

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Ingredients Related to Skin Types

Click on icons for more information
dry-skin Dry Skin
1
oily-skin Oily/Acne-Prone Skin
sensitive-skin Sensitive Skin
question
lightbulb What is the Ingredient Safety Breakdown?

Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.

muscle Pro Tip Alert!

EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.

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Ingredient Safety Breakdown

EWG Health Ratings
Low risk
Medium risk
High risk
Unknown risk
50% 10% 40%

Product ingredient list

Showing first 5 of 10 ingredients
EWG CIR Ingredient Name & Cosmetic Functions Notes
2 A
Glycerin
Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant, Skin Conditioning
brightening Brightening
Promotes Wound Healing
Hydrating
1 A
Glyceryl Stearate
Emollient, Emulsifying
0 Unknown
Clindamycin Phosphate
ache Ache-fighting
1 A
Stearic Acid
Masking, Fragrance, Emulsion Stabilising, Emulsifying, Sufactant, Refatting, Cleansing
0 Unknown
Isostearyl Alcohol
Emollient, Skin Conditioning
VIEW ALL INGREDIENTS