CoEnzyme Q10 Serum
CoEnzyme Q10 Serum
Product Description
Product overview
A lightweight, antioxidant-rich anti-aging serum combining 2% Coenzyme Q10, 8% Matrixyl 3000 peptides, and 1% Hyaluronic Acid to energize skin cells, boost collagen production, and smooth fine lines & wrinkles. By Timeless Skin Care.
Cellular Energy Boost
2% CoQ10 (Ubiquinone) energizes skin cells by supporting ATP production, helping rebuild lost collagen and elastin for firmer skin.
Texture & feel
SENSORYCellular Energy Boost
2% CoQ10 (Ubiquinone) energizes skin cells by supporting ATP production, helping rebuild lost collagen and elastin for firmer skin.
Peptide Powerhouse
8% Matrixyl 3000 (Palmitoyl Tripeptide-1 & Tetrapeptide-7) can increase collagen synthesis by up to 258%, serving as a safe retinoid alternative.
Deep Hydration
1% pure Hyaluronic Acid binds up to 1000x its weight in water, plumping skin and smoothing texture from within.
Antioxidant Defense
CoQ10 and Vitamin E work together to neutralize free radicals and protect against environmental damage and premature aging.
Safety & compatibility
SAFEContains no retinoids, salicylic acid, hydroquinone, or chemical sunscreens. The brand confirms this serum is suitable for use during pregnancy and breastfeeding when used as directed.
Contains Polysorbate 20 and Palmitoyl peptides (palmitic acid base) within the Matrixyl 3000 complex, which may feed malassezia yeast in susceptible individuals. Patch test recommended.
Oil-free, silicone-free formula with no heavy occlusives. Very unlikely to clog pores. Suitable for acne-prone skin.
Fragrance-free, paraben-free, dye-free formula with only 13 ingredients. Gentle enough for sensitive skin. No known irritants aside from the mild preservative benzyl alcohol.
CoQ10 may support skin-brightening effects. If you have vitiligo, consult your dermatologist before use, as uneven tone may become more noticeable.
Safe to layer with Vitamin C, retinol, AHAs, and BHAs. Peptides and CoQ10 complement these actives without causing irritation or interaction issues.
Ingredient breakdown
INGREDIENTSUbiquinone (Coenzyme Q10) 2%Proven
A naturally occurring antioxidant found in every cell of the body, essential for energy (ATP) production. Levels in the skin decline significantly with age. Topical application replenishes these levels, helping protect against oxidative stress and supporting collagen preservation.
- Research: Studies show topical CoQ10 at 0.3%+ can reduce wrinkle depth and protect against UV-induced oxidative damage.
- Mechanism: Supports mitochondrial function and ATP production in skin cells, boosting cellular energy for repair and regeneration.
- Concentration: 2% is a high and effective concentration, well above the levels shown effective in clinical studies.
Matrixyl 3000 (Palmitoyl Tripeptide-1 & Palmitoyl Tetrapeptide-7) 8%Proven
A renowned anti-aging peptide complex that stimulates fibroblast cells to produce collagen and elastin. Composed of two signal peptides that work synergistically to rebuild skin structure and reduce inflammation.
- Research: Clinical studies by Sederma show Matrixyl 3000 can increase collagen synthesis by up to 258% and significantly reduce wrinkle depth.
- Palmitoyl Tripeptide-1: A signal peptide (pal-GHK) that tells skin to produce more collagen, supporting firmness and plumpness.
- Palmitoyl Tetrapeptide-7: Reduces production of interleukin-6 (IL-6), limiting inflammation and slowing collagen degradation.
Hyaluronic Acid 1%Proven
A powerful humectant naturally found in the skin's extracellular matrix. Capable of binding up to 1000 times its weight in water, it draws moisture into the skin to plump and hydrate, reducing the appearance of fine lines.
- Function: Acts as a surface-level humectant, attracting water to the upper skin layers for immediate plumping and smoothing effects.
- Skin-Identical: HA is a natural moisturizing factor already present in your skin, making it extremely well-tolerated.
Tocopherol (Vitamin E) <1%Proven
A fat-soluble antioxidant that protects cell membranes from free radical damage. Works synergistically with CoQ10 to enhance overall antioxidant protection and improve moisture retention.
- Synergy: Vitamin E regenerates after neutralizing free radicals, especially when paired with other antioxidants like CoQ10.
- Barrier Support: Helps strengthen the skin's lipid barrier and reduce transepidermal water loss.
Aloe Barbadensis (Aloe Vera) <1%Promising
A well-known soothing and hydrating botanical extract with anti-inflammatory properties. Helps calm the skin and supports its natural healing processes.
- Benefits: Contains natural humectants that help attract moisture to the skin while providing a soothing, calming effect.
- Skin Repair: Traditionally used to support wound healing and reduce inflammation, though clinical evidence varies.
13 ingredients
Water, Glycerin, Butylene Glycol, Carbomer, Polysorbate 20, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Ubiquinone, Aloe Barbadensis Extract, Hyaluronic Acid, Tocopherol, Benzyl Alcohol, Dehydroacetic Acid
Where it fits in your routine
ROUTINEApply from thinnest to thickest consistency. Use AM and/or PM. Shake well before use — natural separation may occur. Layer under moisturizer for best results.
How to use
HOW TO USECleanse & Prep
Start with freshly cleansed skin. Pat dry or leave slightly damp for enhanced absorption of the hyaluronic acid.
Shake the Bottle
Give the bottle a good shake before each use. Natural ingredient separation can occur — if the dropper looks clear, shake it until the product appears evenly mixed.
Apply 2–3 Drops
Dispense 2–3 drops onto your fingertips and spread the serum evenly over your face and neck. Gently pat into the skin until fully absorbed.
Wait & Follow Up
Allow the serum to fully absorb before applying your next product. Follow with your favorite moisturizer. Apply sunscreen in the morning for UV protection.
Who is it for?
WHOPerfect for you if:
- You want to address fine lines, wrinkles, and loss of firmness
- You prefer a minimalist, clean ingredient formula
- You need a pregnancy-safe anti-aging serum
- You want a retinoid-free alternative for sensitive skin
- You prefer fragrance-free, affordable skincare
- You want high concentrations of actives at a budget price
- You use prescription retinoids and need a gentle hydrating serum
Consider alternatives if:
- You have vitiligo or hypopigmentation concerns
- You are prone to fungal acne (contains Polysorbate 20 and palmitoyl peptides)
- You want an all-in-one serum with niacinamide, ceramides, or SPF
- You prefer a thick, creamy serum texture over a watery liquid
- You want a larger bottle size for the face and body
Skin type compatibility
SKIN TYPESOil-free, lightweight watery texture absorbs quickly without adding any shine or greasiness. Will not clog pores.
Hyaluronic acid and glycerin provide hydration, but very dry skin will need a rich moisturizer layered on top for adequate moisture.
Lightweight formula balances well across different face zones — hydrating dry areas without adding oil to the T-zone.
Fragrance-free, minimal ingredient formula with only 13 ingredients. Widely praised by users with sensitive and reactive skin. No irritation reported.
Non-comedogenic, oil-free, and silicone-free. However, those with fungal acne should be cautious due to Polysorbate 20 and palmitoyl peptides.
Results timeline
MONTH 4+Immediate Hydration & Plumpness
Skin feels noticeably softer, smoother, and more hydrated thanks to Hyaluronic Acid and Glycerin. A subtle dewy glow appears, and the skin barrier feels more comfortable.
80% noticed improved hydrationImproved Texture & Smoothness
Fine lines begin to look softer as peptides stimulate collagen synthesis. Skin texture becomes smoother and more even. Many reviewers report visible improvement within the first month.
65% noticed smoother skin textureVisible Wrinkle Reduction & Firmness
With consistent twice-daily use, deeper wrinkles appear diminished. Skin looks firmer and more resilient. The combined effects of CoQ10 and Matrixyl 3000 become more apparent over time.
55% noticed reduced wrinkle depthLong-Term Anti-Aging Protection
Continued antioxidant protection helps prevent new damage. Collagen levels are maintained, and the skin appears more youthful, resilient, and evenly toned with sustained daily use.
70% reported overall younger-looking skinRatings by platform
4K+ REVIEWSPros & cons
BALANCEDPraised
- High concentration of actives (2% CoQ10, 8% Matrixyl 3000, 1% HA) at an affordable price
- Minimalist formula with only 13 ingredients — no fillers
- Completely fragrance-free, paraben-free, cruelty-free, and vegan
- Lightweight, non-greasy texture absorbs quickly and layers well
- Safe for pregnancy and breastfeeding
- Noticeable hydration and smoothing results within weeks
- Works well under makeup and sunscreen without pilling
- Available in cost-effective 4oz refill size
Criticized
- Small 1oz bottle only lasts about 1 month with twice-daily use
- Formula separates naturally and requires shaking before each use
- Results may plateau after initial improvement period
- Not suitable for people with vitiligo
- Contains Polysorbate 20 — not ideal for fungal acne prone skin
- Watery texture can feel insufficient for very dry skin without layering
Budget-friendly alternatives (dupes)
DUPES
Contains CoQ10 with Squalane and Syn-Tacks peptide instead of Matrixyl 3000. Includes silicones (dimethicone). Cheaper per oz but lower concentration of Q10 and different peptide complex.
Contains Matrixyl 3000 plus additional peptide complexes (Syn-Ake, Relistase) and HA, but lacks CoQ10 antioxidant. More peptide variety but no antioxidant component.
Same Matrixyl 3000 peptide and HA formula from Timeless, but without the CoQ10 antioxidant. Ideal if you already use another antioxidant or cannot tolerate Ubiquinone.
Comparison with competitors
SIDE-BY-SIDETimeless CoQ10 Serum
Storage & shelf life
24 MONTHS24 months from the date of manufacture. Refrigeration is suggested to help extend shelf life and maintain freshness.
Store in a cool, dry place away from direct sunlight. Refrigeration is recommended for optimal potency and freshness.
Opaque glass dropper bottle that protects ingredients from light degradation. Also available in single-use pouch packaging (28 per box).
Yes, 30ml / 1 oz is under the 100ml TSA carry-on limit. Single-use pouches are also available for travel convenience.
Frequently asked questions
FAQYes. Timeless Skin Care confirms this serum is suitable for use during pregnancy and breastfeeding when used as directed. It contains no retinoids, salicylic acid, hydroquinone, or chemical sunscreens — the common ingredients flagged for pregnancy. The formula is gentle with only 13 clean ingredients. As always, consult your healthcare provider if you have specific concerns.
Use with caution. The Matrixyl 3000 complex contains Polysorbate 20 and palmitoyl peptides (which have a palmitic acid base), both of which may feed malassezia yeast in susceptible individuals. If you are prone to fungal acne, consider Timeless' Matrixyl 3000 Serum (which has the same concerns) or look for a CoQ10 product specifically formulated without these ingredients. A patch test is recommended.
Yes. CoQ10 and Matrixyl 3000 peptides are compatible with virtually all common actives including retinol, vitamin C, AHAs (glycolic, lactic acid), and BHAs (salicylic acid). Many users layer this serum with Timeless' own Vitamin C serum or with prescription retinoids like Retin-A. The CoQ10 actually provides complementary antioxidant protection that pairs well with these actives.
This serum is recommended for all skin types, especially those showing visible signs of aging. The lightweight, oil-free formula works particularly well for oily, combination, and sensitive skin. Dry skin types will benefit from the hyaluronic acid but should layer a richer moisturizer on top. The only exception: it is not recommended for people with vitiligo, as CoQ10 may affect pigmentation.
Most users notice improved hydration and a smoother, plumper skin texture within the first 1–2 weeks. Visible reduction in fine lines typically becomes apparent after 4–8 weeks of consistent twice-daily use. Deeper wrinkle improvements generally require 2–3 months of regular use. Results may vary — some reviewers report dramatic improvements within days, while others see gradual progress.
Apply after cleansing and toning, but before heavier serums and moisturizers. The general rule is thinnest to thickest. A typical routine: Cleanser → Toner → Vitamin C Serum (if using) → CoQ10 Serum → Moisturizer → Sunscreen (AM). It can be used both morning and evening. Many users find evening application particularly effective, especially when paired with a retinol or prescription retinoid.
This serum has a comedogenic rating of 1 out of 5, meaning it is very unlikely to clog pores. The formula is oil-free, silicone-free, and contains no heavy occlusives or emollients. It is well-suited for acne-prone skin. Multiple reviewers confirm they experienced no breakouts from this product, even those with sensitive, acne-prone complexions.
The serum is effective for 24 months from the date of manufacture. For best results, use upon receipt and store in the refrigerator. With the suggested 2–3 drops per use, a 1oz bottle lasts approximately 1 month with daily use. A 4oz refill bottle is available for better long-term value. Remember to shake well before each use, as natural separation of ingredients can occur.
Verdict: The Timeless Skin Care CoEnzyme Q10 Serum delivers an impressive amount of proven anti-aging actives — 2% CoQ10, 8% Matrixyl 3000, and 1% Hyaluronic Acid — in a minimalist, 13-ingredient formula at a price that undercuts most competitors. It earns high marks for its clean, transparent formulation with clearly disclosed concentrations and its suitability for sensitive and pregnancy-safe routines. The lightweight texture layers beautifully and works for virtually all skin types. Points are deducted for the small 1oz bottle size, the need to shake before use due to natural separation, and its unsuitability for fungal acne-prone skin. Overall, this is one of the best-value anti-aging peptide serums on the market — a cult favorite for good reason.
Product Overview
What are Quick Product Notes?
Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.
Pro Tip Alert!
Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.
Quick Product Notes
Paraben-Free
Paraben-Free
Understanding Parabens
Parabens are a large group of preservatives which are used to prevent bacteria growing in cosmetic formulations. There has been some healthy controversy surrounding them due to a few studies finding paraben presence in breast tumours and breast tissue. However, the majority of the scientific community have deemed these findings non-conclusive due to the limitations of these studies. There's still a lot of support for avoiding parabens following the better safe than sorry route. If you do we completely support you! If you are concerned about the health safety of parabens, then feel free to avoid them by looking out for the Paraben-Free icon. If not, don't worry about it - they do have had one of the longest safety records as preservatives!
Which Ingredients are classified as Paraben?
A product will be paraben-free if it does not contain any of the following parabens:
- Sodium Isobutylparaben
- Sodium Ethylparaben
- Sodium Butylparaben
- Propylparaben
- Isopropylparaben
- Isobutylparaben
- Sodium Propylparaben
- Butylparaben
- Ethylparaben
- Sodium Methylparaben
- Methylparaben
Sulfate-Free
Sulfate-Free
Understanding Sulfates
Sulfates are a large group of ingredients which act as cleansing agents in Cosmetics. They help loosen up the dirt and grime from your skin and hair to allow for water to wash it away with ease. However some sulfates are so good at their job, they can wash off your skin’s own natural oils that keep it moisturised and protected which can lead to dryness and irritation. Most people will find no issues with sulfate, however if you find your skin doesn't like sulfates then free feel to avoid them by looking out for the sulfate-free icon on Skincarisma.
Which ingredients are classified as sulfates?
We've taken the Sulfates which are considered more harsh for our Sulfate-Free status. A product will be Sulfate-Free if it does not contain any of the following Sulfates:
- TEA-Dodecylbenzenesulfonate
- Ammonium Laureth Sulfate
- Sodium Lauryl Sulfate
- PEG-15 Cocamine
- Sodium Laureth Sulfate
- Sodium Cocoyl Sarcosinate
- Sodium C14-16 Olefin Sulfonate
- Dioctyl Sodium Sulfosuccinate
- Ammonium Xylenesulfonate
- Ammonium Lauryl Sulfate
- Sodium Xylenesulfonate
- Sodium Myreth Sulfate
- Sodium Lauryl Sulfoacetate
Alcohol-Free
Alcohol-Free
Understanding Simple Alcohols
Alcohol ingredients are widely used in cosmetics and come in different types. For the most part alcohols are not problematic at all. However one type of alcohols, simple alcohols can be quite drying to the skin because it evaporates very quickly. This can cause irritation which can also lead to other skin complications. These alcohols should never be used alone on your skin, but combined with other cosmetic ingredients, they are normally without issue. However, for some people with sensitive and easily irritable skin, avoiding products with these simple alcohols may be beneficial. If you find your skin doesn't like these simple alcohols, then free feel to avoid them by looking out for the Alcohol-Free icon.
Which Ingredients are classified as Alcohol?
A product will be alcohol-free if it does not contain any of the following alcohol ingredients:
- SD Alcohol
- Alcohol Denat
- Isopropyl Alcohol
- Alcohol
Silicone-Free
Silicone-Free
Understanding Silicones
If you've ever used a skincare, makeup or beauty product that's made your skin look and feel smoother tempoarily - it's likely contained Silicone. They are a popular class of ingredients found in cosmetics due to their smooth, soft, easy-to-spread and smooth properties that help creates an artificial layer/barrier on top of skin or hair (commonly found in conditioners).
For the same reasons they are popularly used, they are also commonly avoided. Anecdotally, many individuals have reported that Silicones cause/excerbate breakouts, irritation, cause a feeling of skin being unable to breathe, cause clumping of cosmetic products and find it difficult to wash off. As a result, those who find them problematic are avoiding them and increasingly, cosmetic companies are avoiding them as well.
If you have had bad experiences with Silicones in the past, or suspect they are problematic then look out for the tick on the Silicone-free label.
Disclaimer
The Silicone-free label only includes the most common Silicone ingredients that have indentified been reported by individuals that could potentially cause issues.
These include: Amodimethicone, Behenoxy Dimethicone, Bis-Aminopropyl Dimethicone, Cetearyl Methicone, Cetyl Dimethicone, Cyclomethicone, Cyclopentasiloxane, Dimethicone, Dimethicone Copolyol, Dimethiconol, Methicone, Phenyl Trimethicone, Phenyl Trimethicone, Stearoxy Dimethicone, Stearyl Dimethicone, Trimethylsilylamodimethicone.
Note, that this does not include all ingredients part of the Silicone class of ingredients.
EU Allergen-Free
EU Allergen-Free
Understanding the Identified Contact Allergens
The EU's Scientific Committee on Consumer Safety (SCCS) has identified and established 26 cosmetic ingredients that are likely contact allergens (potential to cause skin allergies) as demonstrated in clinical or epidemiological studies. The EU's SCCS have recommend cosmetic companies to disclose them on the labels if used and in cases where the concentration exceeds 0.001% in leave-on products and 0.01% in rinse-off products, then they must be labelled.
Look out for the tick on the EU-Allergen free label to know your cosmetic is free from any of the 26 identified cosmetic ingredients.
For more information regarding the EU's Scientific Committee on Consumer Safety, please visit their official website.
Disclaimer
The EU Allergen Free label is for the 26 ingredients identified by the EU SCCS and products will be only flagged if a suspected ingredient is on it's ingredient list. It is possible for cosmetics to contain one of the suspect ingredients without it appearing on the ingredient list due to it not reaching the concentration threshold to disclose it and cosmetic manufacturers choice to not disclose it.
Also note, the EU Allergen Free label is not personalized for your own allergies you may have and it does not constitute as medical advice. For your specific case, always consult your medical professiona such as dermatologist, physician, pharmacist, or health care provider - please read our medical disclaimer for more information.
Fungal Acne (Molassezia) Safe
Fungal Acne (Molassezia) Safe
Understanding Fungal Acne (Pityrosporum Folliculitis/Malassezia Folliculitis)
Pityrosporum Folliculitis/Malassezia folliculitis or simply known as Fungal Acne is a persistent acne-like condition that commonly responds poorly to traditional acne-treating methods. Unlike most cases of Acne where bacteria is the culprit, Fungi is the culprit of Fungal Acne (Hence the name!). There are certain classes & groups of ingredients that have been shown to promote and feed the growth of the Fungal Acne, Fungi such as fatty acids, oils, esters, polysorbates and fermented ingredients.
For more information regarding Fungal Acne, please visit Simple Skincare Science (f.c) - #3 of our Recommend Skincare Resources for an amazing comprehensive guide!
Please Read: How to use the Fungal Acne (Malassezia) Label
At SkinCarisma, we've done our best to identify as many ingredients as possible but note the fungal-free label may not be 100% accurate due to the complexconditions and combination of ingredients that malezzeria can thrive on.
Additionally, products that may contain ingredients that have shown to feed Malassezia may not neccessarily exacerbate the condition due to concentration of ingredient used in the product, this information is simply not available on the products.
As a result, please note this is only an experimental label that can be best used to possible identify problematic products you have used in the past. It is in no way a perfect identifier nor a predictor in whether or not it will exacerbate or cause fungal acne. It will continue to be worked on as more information and research comes to light.
If you find any ingredients you believe should be included, please email us at snails@skincarisma.com.
Disclaimer
Due to the lack of substantial research into this area it is very likely there are other ingredients and class/groups of ingredients that could feed Fungal Acne which have not been indentified.
The Fungal-Safe label does not constitute as medical advice. For your specific case, always consult your medical professiona such as dermatologist, physician, pharmacist, or health care provider - please read our medical disclaimer for more information.
What are Notable Effects & Ingredients?
Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging «promises» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.
We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.
Pro Tip Alert!
Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.
Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you
Notable Effects & Ingredients
Anti-Aging from 5 ingredient(s):
Brightening from 2 ingredient(s):
Promotes Wound Healing from 3 ingredient(s):
What are Ingredients Related to Skin Type?
Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.
We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.
Pro Tip Alert!
A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.
One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!
Ingredients Related to Skin Types
Dry Skin
Oily/Acne-Prone Skin
Sensitive Skin
What is the Ingredient Safety Breakdown?
Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.
Pro Tip Alert!
EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.
Ingredient Safety Breakdown
Product ingredient list
| EWG | CIR | Ingredient Name & Cosmetic Functions | Notes |
|---|---|---|---|
| 1 |
Water
Solvent, Skin Conditioning
|
|
|
| 2 |
Glycerin
Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant, Skin Conditioning
|
Brightening
Promotes Wound Healing
Hydrating
|
|
| 1 |
Butylene Glycol
Solvent, Skin Conditioning, Masking, Fragrance, Humectant, Viscosity Controlling, Viscositydecreasing Agent
|
Hydrating
|
|
| 1 |
Carbomer
Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Gel Forming
|
|
|
| 3 |
Polysorbate 20
Surfactant, Emulsifying
|
|