Cold Plasma Plus+ The Essence
Cold Plasma Plus+ The Essence
Product Description
Product overview
A lightweight, fast-absorbing essence powered by Copper Tripeptide-1, Niacinamide, and a 6-peptide complex. Uses a proprietary liquid crystal delivery system to visibly improve radiance, texture, tone, and hydration. Clinically shown to boost skin hydration by 93% in 4 weeks.
Liquid Crystal Delivery System
Proprietary technology that mimics the skin's natural lipid structure for faster, more effective absorption of active ingredients into the skin's surface.
Texture & feel
SENSORYLiquid Crystal Delivery System
Proprietary technology that mimics the skin's natural lipid structure for faster, more effective absorption of active ingredients into the skin's surface.
6-Peptide Complex
Contains Copper Tripeptide-1, Argireline, and four additional signal peptides that work synergistically to support collagen production and firm the skin.
Multi-Concern Targeting
Addresses radiance, texture, tone, pore size, redness, and hydration in a single lightweight step. Clinically validated across multiple concerns.
Intense Hydration Boost
Combines Hyaluronic Acid, Glycerin, and Rice Ferment Filtrate to deliver deep hydration. 93% showed significant improvement in hydration after 4 weeks.
Safety & compatibility
SAFEContains Copper Tripeptide-1, which lacks comprehensive pregnancy safety data. No retinoids, salicylic acid, or hydroquinone present. Consult your doctor before use.
Not fungal acne safe. Contains Saccharomyces/Rice Ferment Filtrate, Polysorbate 20, Linoleic Acid, and Linolenic Acid which can feed Malassezia yeast.
Fragrance-free, alcohol-free formula with a low irritation profile. Suitable for sensitive skin, though patch testing is always recommended with peptide-rich formulas.
Rated 1/5 for comedogenicity. Oil-free, silicone-free formula is unlikely to clog pores. Safe for acne-prone skin (unless you have fungal acne).
Can be used alongside retinol, vitamin C, and AHAs/BHAs. The niacinamide and peptides may help buffer potential irritation from actives.
Copper Tripeptide-1 should not be used at the same time as strong direct acids (like glycolic at high %) or pure Vitamin C (L-Ascorbic Acid) to avoid oxidation. Space application by 30 minutes.
Ingredient breakdown
INGREDIENTSCopper Tripeptide-1 (GHK-Cu)Proven
A naturally occurring copper-peptide complex with potent wound healing, collagen-stimulating, and anti-inflammatory properties. The signature blue-hued ingredient in the Cold Plasma Plus+ line that helps firm, smooth, and revitalize aging skin.
- Collagen Production: Stimulates synthesis of collagen, elastin, and glycosaminoglycans for firmer, more elastic skin.
- Wound Healing: Promotes breakdown of damaged collagen in scar tissue and replaces it with healthy new collagen.
- Clinical Evidence: Studies show GHK-Cu can improve skin elasticity, clarity, firmness, and reduce fine lines and wrinkles.
- Antioxidant: Significant anti-inflammatory and antioxidant effects protect against environmental damage.
Niacinamide (Vitamin B3) ~3-5%Proven
A powerhouse brightening and barrier-strengthening ingredient listed 5th in the INCI, suggesting a meaningful concentration. Targets uneven tone, enlarged pores, and inflammation.
- Brightening: Inhibits melanin transfer to reduce hyperpigmentation and dark spots over time.
- Pore Minimizing: Helps regulate sebum production and visibly reduces pore size with consistent use.
- Barrier Support: Boosts ceramide production to strengthen the skin's moisture barrier.
3-O-Ethyl Ascorbic AcidProven
A stabilized, water-soluble derivative of Vitamin C that resists oxidation better than pure L-Ascorbic Acid. Provides antioxidant protection and brightening benefits without the instability issues of pure vitamin C.
- Stability: More stable than L-Ascorbic Acid, maintaining potency throughout the product's shelf life.
- Antioxidant: Neutralizes free radicals from UV exposure and environmental pollution.
- Brightening: Helps reduce hyperpigmentation and even out skin tone with consistent use.
Hyaluronic AcidProven
A powerful humectant that can hold up to 1,000 times its weight in water. Draws moisture to the skin's surface for immediate plumping and hydration.
- Hydration: Attracts and retains moisture in the upper skin layers for a plump, dewy look.
- Skin Barrier: Helps strengthen the skin's moisture barrier and prevents transepidermal water loss.
Acetyl Hexapeptide-8 (Argireline)Promising
Known as "topical Botox," this peptide helps relax facial muscles to reduce the appearance of expression lines, particularly around the forehead and eyes.
- Mechanism: Inhibits SNARE complex formation, reducing neurotransmitter release that triggers muscle contraction.
- Clinical Data: Studies show up to 30% reduction in wrinkle depth after 30 days of consistent use at effective concentrations.
Saccharomyces/Rice Ferment FiltratePromising
Listed 2nd in the ingredient list, this fermented rice extract is a key component of the formula. Rich in amino acids, vitamins, and minerals that nourish and brighten the skin.
- Brightening: Fermented ingredients contain kojic acid and other compounds that help even skin tone.
- Nutrient-Rich: Provides amino acids, B vitamins, and minerals to nourish and revitalize dull skin.
29 ingredients
Water/Aqua/Eau, Saccharomyces/Rice Ferment Filtrate, Glycerin, Pentylene Glycol, Niacinamide, Butylene Glycol, 1,2-Hexanediol, Polysorbate 20, Dimethyl Isosorbide, Chlorphenesin, Copper Tripeptide-1, 3-O-Ethyl Ascorbic Acid, Hyaluronic Acid, Sodium Phytate, Sodium Citrate, Carbomer, Phenoxyethanol, Citric Acid, Phosphatidylcholine, Linoleic Acid, Potassium Sorbate, Acetyl Hexapeptide-8, Acetyl Tetrapeptide-11, Acetyl Tetrapeptide-9, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Linolenic Acid, Tocopherol, Ascorbyl Palmitate
Where it fits in your routine
ROUTINEApply after cleansing on bare skin or after toner. Use morning and evening. Allow to absorb fully before layering serums or moisturizers.
How to use
HOW TO USECleanse Your Face
Start with clean, dry skin. Use your favorite gentle cleanser and pat dry with a soft towel.
Dispense the Essence
Pour about two shakes of the essence into the palm of your hand. Press palms together to wet both hands evenly.
Pat Onto Face and Neck
Gently pat and press the essence onto your face and neck to ensure even coverage. Do not rub — patting helps the liquid crystal system absorb more effectively.
Wait and Layer
Allow a few minutes for full absorption before applying your next treatment, serum, or moisturizer. Use morning and evening for best results.
Who is it for?
WHOPerfect for you if:
- You want a lightweight, multi-tasking essence that targets multiple signs of aging
- You have dull, uneven skin tone or texture concerns
- You prefer fragrance-free, clean formulas with clinical backing
- You want peptide-powered anti-aging without heavy creams
- You need a hydrating prep step that boosts your entire routine
- You have normal, dry, oily, or combination skin
Consider alternatives if:
- You have fungal acne (Malassezia) — this formula contains ferments and fatty acids
- You are pregnant or breastfeeding and want to avoid copper peptides without doctor approval
- You are on a strict budget — at $105, this is a premium investment
- You prefer a thick, rich texture — this is very lightweight and watery
- You need intensive anti-wrinkle treatment — consider their Advanced Serum Concentrate instead
Skin type compatibility
SKIN TYPESLightweight, watery texture absorbs instantly without adding oil or shine. Niacinamide helps regulate sebum. Oil-free and silicone-free formula.
Provides excellent hydration boost with HA and glycerin, but very dry skin will need a richer moisturizer on top. Best used as a hydrating prep layer.
Balances beautifully across different face zones. Hydrates dry areas without overloading oily zones. Ideal lightweight layer for combination skin.
Fragrance-free with low irritation potential. Niacinamide is anti-inflammatory. Patch test recommended as copper peptides may cause sensitivity in reactive skin.
Non-comedogenic (1/5) and oil-free. Good for regular acne-prone skin. However, not suitable for fungal acne due to ferment and polysorbate content.
Excellent for aging concerns. Copper peptides and the 6-peptide complex target firmness, fine lines, and collagen production. Clinically validated results for mature skin.
Results timeline
WEEK 8+Instant Hydration & Softness
Skin feels instantly hydrated, soft to the touch, and refreshed. The liquid crystal delivery system provides an immediate dewy, plump feeling.
84% noticed immediate softnessImproved Skin Texture
Skin surface begins to feel smoother and more refined. The essence preps skin more effectively for subsequent products, boosting their performance.
89% felt smoother skinVisible Hydration & Radiance
Significant improvement in skin hydration levels clinically measured. Skin appears more radiant, brighter, and healthier with a visible glow.
93% showed improved hydrationTone, Texture & Pore Improvement
Significant improvement in skin tone, pore size, radiance, brightness, texture, and reduction in redness. The full peptide complex shows cumulative anti-aging benefits.
87% reported more radiant skinRatings by platform
680+ REVIEWSPros & cons
BALANCEDPraised
- Lightweight, fast-absorbing texture that layers beautifully under other products
- Clinically proven hydration improvement (93% in 4 weeks)
- Impressive 6-peptide complex including Copper Tripeptide-1 and Argireline
- Fragrance-free, paraben-free, vegan, and cruelty-free formula
- Visibly improves radiance, tone, and texture with consistent use
- Suitable for all skin types — works for oily, dry, and combination skin
- Clean ingredient list with only 29 ingredients
- HSA/FSA eligible purchase
Criticized
- Premium price at $105 for 4.7 oz may be prohibitive for some budgets
- Not fungal acne safe due to fermented ingredients and polysorbate
- Copper peptide can have a slight metallic scent that some find off-putting
- Very lightweight — those with very dry skin may need additional moisture
- Anti-wrinkle results require patience (8+ weeks for visible improvement)
- Bottle may run out quickly with recommended twice-daily use
- Cannot be layered directly with pure L-Ascorbic Acid vitamin C serums
Budget-friendly alternatives (dupes)
DUPESContains the same key Copper Tripeptide-1 plus a multi-peptide complex. Serum consistency instead of essence. Lacks the rice ferment filtrate and liquid crystal delivery system, but delivers comparable peptide benefits at a fraction of the cost.
Different active mechanism (snail mucin vs. copper peptide) but targets the same concerns: hydration, texture, tone, and skin repair. Lighter on peptides but excellent for hydration and soothing. Much more affordable at 100ml.
Also features a ferment filtrate base with niacinamide for brightening and hydration. Lacks the advanced peptide complex and copper tripeptide but delivers similar radiance and tone-evening effects at a significantly lower price point.
Comparison with competitors
SIDE-BY-SIDEStorage & shelf life
12 MONTHS12 months after opening
Store in a cool, dry place away from direct sunlight. Keep the cap tightly closed. No refrigeration required, but avoid storing in humid bathrooms.
Opaque plastic bottle with pour cap. The opaque packaging helps protect light-sensitive ingredients like Vitamin C derivatives and copper peptide.
Yes — 4.7 oz (139ml) exceeds the 100ml TSA carry-on limit, so you would need to check it or decant into a smaller travel container. The 7.2 oz size is definitely check-in only.
Frequently asked questions
FAQUse with caution. While this essence does not contain retinoids, salicylic acid, hydroquinone, or chemical sunscreens, it does contain Copper Tripeptide-1 (GHK-Cu), which lacks comprehensive safety data during pregnancy and breastfeeding. The niacinamide, hyaluronic acid, and vitamin C derivative in the formula are generally considered pregnancy-safe. We recommend consulting your OB-GYN or dermatologist before using copper peptide products during pregnancy or while nursing.
No, this product is not fungal acne safe. It contains several ingredients that can feed Malassezia yeast: Saccharomyces/Rice Ferment Filtrate (fermented ingredient, listed 2nd), Polysorbate 20 (emulsifier), Linoleic Acid, and Linolenic Acid (fatty acids). If you are prone to fungal acne, consider alternatives like simple hyaluronic acid serums or essences specifically formulated without ferments, fatty acids, and polysorbates.
Yes, with one important caveat. This essence pairs well with retinol, AHAs, and BHAs — the niacinamide and peptides can actually help buffer irritation from these actives. However, avoid applying pure L-Ascorbic Acid (vitamin C) at the exact same time as this product, as copper can oxidize pure vitamin C. If you use a pure vitamin C serum, apply it in the morning and use this essence in the evening, or wait 30 minutes between applications. The stabilized vitamin C derivative already in this formula is formulated to work alongside the copper peptide.
This essence is designed for all skin types and performs especially well on oily, combination, and mature skin. Its lightweight, watery texture absorbs quickly without adding heaviness, making it ideal for oily skin. The peptide and niacinamide content makes it excellent for aging and mature skin. Dry skin types will enjoy the hydration boost but should follow with a richer moisturizer. Sensitive skin types generally tolerate it well thanks to the fragrance-free formula, though patch testing is recommended.
You will feel immediate hydration and softness after the first application. Within 1-2 weeks, most users notice smoother skin texture. Clinical studies show that after 4 weeks, 93% of participants demonstrated significant improvement in skin hydration. By 8 weeks of consistent twice-daily use, significant improvements in skin tone, pore size, radiance, brightness, texture, and redness reduction become visible. For full anti-aging peptide benefits, allow 8-12 weeks of consistent use.
Apply this essence as Step 3 in your routine: after cleansing and toner, but before serums, moisturizers, and sunscreen. Pour about two shakes into your palms, press hands together, and pat onto face and neck. Wait a few minutes for full absorption before layering your next products. Use morning and evening for optimal results. This essence is designed to prep your skin and enhance the absorption of subsequent treatments.
This essence has a low comedogenic rating of 1 out of 5, meaning it is very unlikely to clog pores. The formula is oil-free, silicone-free, and does not contain heavy occlusive ingredients. The Niacinamide can actually help minimize pore appearance and regulate sebum production. Clinical studies showed improvement in pore size after 8 weeks. However, individual reactions vary — a small number of users with very reactive skin have reported occasional small breakouts during the initial adjustment period.
The product has a PAO (Period After Opening) of 12 months. With the recommended twice-daily use (about two shakes per application on face and neck), the 4.7 oz / 139ml bottle typically lasts approximately 2-3 months. The larger 7.2 oz / 213ml size will last approximately 3-4 months. Store in a cool, dry place away from direct sunlight and keep the cap tightly closed to maintain potency of the copper peptide and vitamin C ingredients.
Verdict: Perricone MD Cold Plasma Plus+ The Essence is a scientifically impressive, peptide-rich essence that delivers real results for hydration, radiance, and skin texture. The standout Copper Tripeptide-1, combined with a 6-peptide complex and Niacinamide, makes it one of the most ingredient-dense essences in its class. Its lightweight texture, clean formula (fragrance-free, vegan, cruelty-free), and clinical backing justify the premium price for those targeting multiple signs of aging. However, it falls short for fungal acne sufferers due to its ferment-based formula, and the $105 price tag is a significant investment. Best suited for normal, oily, combination, and mature skin types who want a multi-tasking anti-aging essence with proven active ingredients.
Product Overview
Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.
Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.
Quick Product Notes
Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging «promises» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.
We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.
Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.
Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you
Notable Effects & Ingredients
Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.
We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.
A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.
One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!
Ingredients Related to Skin Types
Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.
EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.
Ingredient Safety Breakdown
Product ingredient list
| EWG | CIR | Ingredient Name & Cosmetic Functions | Notes |
|---|---|---|---|
| 1 |
Water
Solvent, Skin Conditioning
|
|
|
| 0 |
Saccharomyces/Rice Ferment Filtrate
Skin Conditioning
|
Hydrating
|
|
| 2 |
Glycerin
Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant, Skin Conditioning
|
Promotes Wound Healing
Hydrating
|
|
| 1 |
Pentylene Glycol
Solvent, Skin Conditioning
|
|
|
| 1 |
Niacinamide
Skin Conditioning, Hair Conditioning, Smoothing
|
Promotes Wound Healing
Redness
Irritation
Dark Spots
Pores
|








