Custom Prescription
Custom Prescription
Product Description
Product overview
A personalized, prescription-strength skincare formula custom-compounded by board-certified dermatologists to target your specific skin concerns including acne, aging, hyperpigmentation, and texture with powerful active ingredients like tretinoin, niacinamide, azelaic acid, and clindamycin.
Custom Compounded Formula
Up to 5 active ingredients blended specifically for your skin concerns by licensed pharmacists.
Texture & feel
SENSORYCustom Compounded Formula
Up to 5 active ingredients blended specifically for your skin concerns by licensed pharmacists.
Board-Certified Dermatologists
Your treatment plan is created and monitored by real dermatology experts, not algorithms.
Convenient Telehealth
No office visits required. Complete your consultation online and receive treatment at your door.
Adjustable Formulations
Your formula can be modified over time as your skin improves or concerns change.
Safety & compatibility
SAFETretinoin is FDA Category C. Studies show potential fetal harm. Avoid during pregnancy and stop 1 month before trying to conceive.
Low systemic absorption means minimal transfer to breast milk, but most dermatologists advise against use. Avoid applying near chest area.
Tretinoin itself is FA-safe and may help, but some inactive ingredients like Glyceryl Stearate can trigger Malassezia. Request gel formulation if FA-prone.
Tretinoin significantly increases photosensitivity. Daily SPF 30+ sunscreen is mandatory. Apply treatment at night only.
Ingredient breakdown
INGREDIENTSTretinoin 0.025-0.1%Gold Standard
The most powerful, clinically-proven retinoid available. Tretinoin (retinoic acid) works immediately without conversion, accelerating cell turnover, boosting collagen production, and regulating sebum to treat both acne and aging simultaneously.
- Acne: 40+ years of clinical evidence as first-line treatment for acne vulgaris
- Anti-Aging: Only topical proven to reverse photoaging and rebuild collagen
- Cell Turnover: Increases from 30 to 14 days, revealing fresher skin
Niacinamide 4%Multi-Tasker
Vitamin B3 derivative that strengthens the skin barrier, reduces inflammation, and brightens skin tone. Works synergistically with tretinoin to minimize irritation while enhancing results.
- Barrier Repair: Increases ceramide and fatty acid production by 34%
- Brightening: Inhibits melanin transfer to reduce dark spots
- Oil Control: Regulates sebum production without over-drying
Azelaic Acid Up to 15%Optional Add-On
A naturally-occurring dicarboxylic acid with antibacterial, anti-inflammatory, and tyrosinase-inhibiting properties. Excellent for acne, rosacea, and hyperpigmentation.
- Antibacterial: Kills P. acnes bacteria without antibiotic resistance risk
- Brightening: FDA-approved for melasma treatment
- Anti-Inflammatory: Reduces redness and inflammatory lesions
Clindamycin 1%Optional Add-On
A topical antibiotic that targets acne-causing bacteria (C. acnes) while reducing inflammation. Often combined with tretinoin for enhanced acne treatment.
- Mechanism: Inhibits bacterial protein synthesis
- Efficacy: 2024 review confirms it as key player in acne management
- Combination: Works best with benzoyl peroxide or tretinoin to prevent resistance
9 ingredients (typical formula)
Active Ingredients: Tretinoin 0.1%, Niacinamide 4%
Inactive Ingredients: BHT, C12-15 Alkyl Benzoate, Caprylic/Capric Triglyceride, Cetyl Alcohol, Ethylhexylglycerin, Glycerin, Glyceryl Stearate, Water
Where it fits in your routine
ROUTINEApply at NIGHT only. Wait 20-30 minutes after cleansing for skin to fully dry before application.
How to use
HOW TO USECleanse Gently
Remove all makeup with a gentle, non-foaming cleanser. Pat dry and wait 20-30 minutes until skin is completely dry.
Apply Pea-Sized Amount
Dispense a pea-sized amount onto fingertips. Dot on forehead, cheeks, chin, and nose. Spread in thin, even layer avoiding eye area, lips, and nostrils.
Wait Before Moisturizing
Allow 15-20 minutes for full absorption before applying moisturizer. This prevents dilution and maximizes efficacy.
Start Slow, Build Up
Beginners: Apply every 3rd night for 2 weeks, then every other night for 2 weeks, then nightly. Reduce frequency if irritation occurs.
Who is it for?
WHOPerfect for you if:
- You have persistent acne that OTC products cannot control
- You want proven anti-aging results backed by decades of research
- You struggle with hyperpigmentation, melasma, or uneven skin tone
- You prefer the convenience of telehealth over in-office visits
- You want a dermatologist-supervised treatment plan
- You are patient and willing to work through an adjustment period
Consider alternatives if:
- You are pregnant, planning pregnancy, or breastfeeding
- You have extremely sensitive skin or active eczema/dermatitis
- You cannot commit to daily sunscreen use
- You need immediate results (tretinoin takes 8-12 weeks)
- You prefer non-prescription skincare approaches
- You have a history of allergic reactions to retinoids
Skin type compatibility
SKIN TYPESTretinoin regulates sebum production and unclogs pores. Ideal candidate with best tolerance to potential dryness.
Can work well with extra moisturization and slower introduction. May experience more peeling initially.
Balances oily T-zone while hydrating dry areas. Apply heavier moisturizer to dry zones.
Requires very gradual introduction. Start with lowest strength (0.025%) and buffer with moisturizer if needed.
First-line treatment for acne. Expect initial purging (2-6 weeks) as tretinoin accelerates comedone clearing.
Results timeline
MONTH 4-6Adjustment Period Begins
Mild dryness, tightness, and flaking may occur as skin adapts. Some redness is normal. This is your skin adjusting to increased cell turnover.
85% experience mild irritationThe Purge Phase
Existing comedones are pushed to surface faster, potentially causing temporary breakouts. This is a sign the product is working—stay consistent!
60% experience purgingVisible Improvements
Acne begins to clear significantly. Skin texture smooths out. Early signs of brightening and reduced hyperpigmentation appear.
75% see noticeable improvementTransformative Results
Major reduction in acne, visible improvement in fine lines and wrinkles. Dark spots fade substantially. Skin appears healthier and more radiant.
90% report dramatic improvementRatings by platform
5K+ REVIEWSPros & cons
BALANCEDPraised
- Access to prescription-strength tretinoin without office visits
- Personalized formulas with up to 5 active ingredients
- Board-certified dermatologists create treatment plans
- Fast turnaround (treatment plan within 24-48 hours)
- Convenient home delivery every 3 months
- Ability to adjust formula as skin improves
- Dramatic improvements in acne and aging reported
- Clean formula free from common irritants
Criticized
- More expensive than generic tretinoin from pharmacy
- Confusing subscription model and auto-billing
- Small product size for the price
- Cannot use with FSA/HSA easily (documentation issues)
- Not available in all states
- Initial purging phase can be discouraging
- Requires strict sun protection commitment
- No refunds on shipped medications
Budget-friendly alternatives (dupes)
DUPESSimilar teledermatology model with up to 3 active ingredients. Free initial consultation vs $20. Slightly lower tretinoin concentrations available (0.009-0.05%).
UK-based service now available in US. Uses similar active ingredients. SmartBase formula includes ceramides and hyaluronic acid for better tolerance.
Use GoodRx for $18 generic tretinoin from local pharmacy plus any 5% niacinamide serum. Same actives, but not combined and requires separate prescriber visit.
From Curology founders, focused on anti-aging. Premium positioning with similar ingredients. Better for aging concerns than acne-focused.
Comparison with competitors
SIDE-BY-SIDECurology
Dermatica
Traditional Dermatologist
Storage & shelf life
6 MONTHS6 months after opening. Tretinoin degrades with light and air exposure.
Store at room temperature (59-77°F). Keep away from direct sunlight and heat. Some users refrigerate to extend stability.
Opaque tube or airless pump to protect light-sensitive tretinoin from degradation.
Yes, TSA-compliant size under 100ml. Keep in carry-on to avoid extreme temperatures in checked luggage.
Frequently asked questions
FAQPregnancy: NO. Tretinoin is FDA Category C and is NOT recommended during pregnancy. Animal studies show potential fetal harm, and there are case reports of birth defects. Stop use at least 1 month before trying to conceive.Breastfeeding: Use with extreme caution. While topical absorption is low, most dermatologists advise against use. Apostrophe does offer tretinoin-free formulas with azelaic acid and niacinamide that are considered safer options for nursing mothers.
It depends on the formula. Tretinoin itself is fungal acne safe and may actually help by increasing cell turnover. However, standard cream formulations contain ingredients like Glyceryl Stearate and Cetyl Alcohol that can feed Malassezia yeast. If you have fungal acne, request a GEL formulation or ask your provider about an FA-safe base. The gel version of tretinoin is typically safer for fungal acne sufferers.
Proceed with caution. When first starting tretinoin, avoid all other actives for at least 4-6 weeks until skin adjusts. After your skin has acclimated:Vitamin C: Use in morning, tretinoin at night.AHAs/BHAs: Avoid combining—use on alternate nights if needed.Retinol: Not necessary—tretinoin is stronger.Niacinamide: Safe to combine (often included in formula).Benzoyl Peroxide: Can be used AM while tretinoin is PM.
Apostrophe works for ALL skin types but performs best onoily and combination skin which tolerate tretinoin with less irritation. These skin types also benefit most from tretinoin's sebum-regulating effects. Dry and sensitive skin types can still use it successfully but require more gradual introduction (every 3rd night), lower concentrations (0.025%), and robust moisturization. Your dermatologist will customize the strength and frequency based on your skin type.
Expect 8-12 weeks for significant improvement. Timeline: Weeks 1-2 show adjustment (dryness, peeling). Weeks 3-6 often include purging (temporary worsening). Weeks 8-12 deliver visible improvement in acne, texture, and tone. Months 4-6 show dramatic results in fine lines and hyperpigmentation. Full anti-aging benefits continue building for 1-2 years of consistent use. Patience is essential—tretinoin is a long-term treatment, not a quick fix.
Apply atNIGHT ONLY after cleansing and before moisturizer. Full routine: 1) Gentle cleanser, 2) Wait 20-30 min for skin to dry completely, 3) Apply pea-sized amount of Custom Rx, 4) Wait 15-20 min for absorption, 5) Apply moisturizer. In the morning, use a gentle cleanser, any serums (vitamin C okay), moisturizer, and SPF 30+ sunscreen. Never apply tretinoin in daytime or skip sunscreen.
No, the formula is non-comedogenic. Tretinoin actually UNCLOGS pores by accelerating cell turnover and preventing the formation of comedones (blackheads and whiteheads). The base ingredients have a comedogenic rating of 0-1. However, during the first 4-6 weeks, you may experience "purging"—existing clogged pores coming to the surface faster. This is temporary and indicates the product is working. If breakouts persist beyond 8 weeks, consult your provider.
6 months after opening (6M PAO). Tretinoin is photosensitive and degrades when exposed to light, air, and heat. The opaque packaging helps protect it, but efficacy decreases over time. Each shipment is compounded fresh for optimal potency. Tips to extend shelf life: Store in a cool, dark place (some refrigerate it), always close the cap tightly, don't leave in bathroom with high humidity, and use within the 3-month subscription cycle.
Verdict: Apostrophe Custom Prescription delivers the gold standard of skincare—prescription tretinoin—with unmatched convenience. The ability to access board-certified dermatologists, custom-compounded formulas with up to 5 active ingredients, and oral medications without office visits makes it a compelling option for anyone serious about treating acne or aging. The formula is clean, effective, and backed by decades of clinical research. However, the premium pricing ($30/month vs $18 for generic tretinoin), confusing subscription practices, and small bottle sizes are valid criticisms.Best for: Those who want professional-grade results without the hassle of traditional dermatology visits and are willing to invest in a comprehensive, supervised treatment plan. Not ideal for budget-conscious users who can access generic tretinoin through traditional prescribers.
Product Overview
Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.
Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.
Quick Product Notes
Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging «promises» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.
We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.
Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.
Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you
Notable Effects & Ingredients
Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.
We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.
A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.
One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!
Ingredients Related to Skin Types
Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.
EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.
Ingredient Safety Breakdown
Product ingredient list
| EWG | CIR | Ingredient Name & Cosmetic Functions | Notes |
|---|---|---|---|
| 0 |
Tretinoin
Skin Conditioning
|
Promotes Wound Healing
Dark Spots
Texture
Pores
|
|
| 1 |
Niacinamide
Skin Conditioning, Hair Conditioning, Smoothing
|
Promotes Wound Healing
Redness
Irritation
Dark Spots
Pores
|
|
| 6 |
BHT
Masking, Fragrance, Antioxidant
|
|
|
| 1 |
C12-15 Alkyl Benzoate
Skin Conditioning, Emollient, Antimicrobial
|
|
|
| 1 |
Caprylic/Capric Triglyceride
Solvent, Skin Conditioning, Masking, Perfuming, Emollient
|
|


