Daily Serum
Daily Serum
Product Description
Plated Skin Science DAILY Serum is a lightweight, deeply hydrating regenerative serum powered by 7.5+ billion platelet-derived exosomes (Renewosomeβ’ technology). Developed with Mayo Clinic physician-scientists, it is clinically shown to visibly minimize wrinkles, redness, and brown spots while strengthening the skin barrier for everyday "glass-skin" glow.
β¨ Texture & Feel
Platelet-Derived Exosomes
7.5+ billion intact, "whole" exosomes deliver growth factors, peptides, and phosphoproteins that signal skin to renew itself.
Mayo Clinic Science
Renewosomeβ’ technology built on 15+ years of regenerative research and 10+ peer-reviewed clinical studies.
Calms Redness
Soothing, anti-inflammatory action visibly reduces redness and supports sensitive, rosacea-prone skin.
Barrier Reinforcing
Daily use strengthens the moisture barrier so skin holds hydration and reacts less to environmental stress.
π‘οΈ Safety & Compatibility
No retinoids, acids, or hydroquinone, but growth factors are not well studied in pregnancy. Check with your OB/derm before use.
No oils, esters, or fatty acids that feed malassezia. The formula is largely fungal-acne friendly.
Compatible with retinoids, vitamin C, niacinamide, and exfoliating acids β apply Plated first, let it dry, then layer.
Fragrance-free, alcohol-free, allergen-free and non-irritating; well tolerated by reactive and rosacea-prone skin.
Contains human platelet extract and hydrolyzed gelatin (animal-derived). Platelets are ethically sourced from FDA-regulated US blood banks.
Contains no oxybenzone, octinoxate, or other reef-damaging UV filters.
π¬ Ingredient Breakdown
𧬠Human Platelet Extract (Exosomes) 7.5B+ / bottle Proven
The hero ingredient and Renewosomeβ’ powerhouse. These platelet-derived exosomes are nano-sized vesicles carrying growth factors, peptides, phosphoproteins, and antioxidants that signal skin cells to repair, renew, and produce collagen.
- Source: 2022 POSH study (Wyles SP, Aesthetic Surgery Journal, 55 participants) found statistically significant improvements in redness, brown spots, wrinkles, color evenness, and luminosity by week 6.
- Source: 98% of trial participants said they would continue using the product.
- Source: Platelets ethically sourced from FDA-regulated US blood banks; exosomes kept intact ("whole") to preserve potency.
π§ Glycerin High (2nd in INCI) Proven
A foundational humectant naturally found in skin. Its low molecular weight lets it pull water into the deeper layers, keeping skin plump, hydrated, and barrier-supported.
- Source: A 2016 study found glycerin to be a more effective humectant than AHAs and hyaluronic acid.
- Source: Also shown to have antimicrobial and skin-protecting properties.
πΎ Pentylene Glycol Undisclosed Promising
A plant-derived humectant and texture enhancer that draws moisture to the skin, smooths the serum's feel, and acts as a mild, gentle preservative to keep the formula microbe-free.
- Source: Part of the 1,2-glycol family; hydrophilic structure makes it an effective moisture binder.
𧴠Caprylyl Glycol & 1,2-Hexanediol Undisclosed Proven
A multitasking duo that hydrates and softens skin while boosting the antimicrobial activity of the system β allowing a clean, fragrance-free, paraben-free preservation approach.
- Source: Caprylyl glycol is a fatty-alcohol-derived humectant that supports a healthy barrier without drying.
- Source: 1,2-Hexanediol functions as humectant, emollient, solvent, and preservative booster.
𧩠Silanetriol & Hydrolyzed Gelatin Undisclosed Promising
Silanetriol (a bioavailable silicon source) and hydrolyzed gelatin support a smoother, firmer-looking surface and help condition the skin alongside the exosome complex.
- Source: Silicon-based actives are associated in research with connective-tissue and skin-conditioning support.
π Arginine Low (end of INCI) Promising
An amino acid the body uses to build collagen and keratin. As a topical it offers antioxidant benefits and helps support repair of damaged skin.
- Source: Arginine can be fungal-acne triggering only in the presence of oils/esters β none of which appear in this oil-free formula.
13 ingredients
Water (Purified Water), Glycerin, Pentylene Glycol, Polyacrylate Crosspolymer-6, Human Platelet Extract, Caprylyl Glycol, 1,2-Hexanediol, Hydrolyzed Gelatin, Silanetriol, Arginine, Sodium Benzoate, Avena Sativa (Oat) Kernel Extract, Potassium Sorbate.
π Where It Fits in Your Routine
Apply Plated FIRST, on clean dry skin, before any other product. Let it fully dry (~5 minutes), then layer the rest of your routine β including retinoids, vitamin C, or acids.
π How to Use
Cleanse & dry
Wash your face and pat completely dry. Exosomes are best applied to bare, clean skin for maximum absorption.
Apply 1 pump
Dispense one pump and gently press over the face and neck once daily (morning or evening). Avoid direct eye contact.
Let it absorb
Wait about 5 minutes until fully dry. This protects the exosomes and lets them go to work before layering.
Seal & protect
Follow with moisturizer and, in the AM, a broad-spectrum SPF. Exfoliate regularly to manage increased cell turnover.
π€ Who Is It For?
β Perfect for you if:
- You want everyday anti-aging with cutting-edge exosome technology
- You have mild-to-moderate fine lines, dullness, or uneven tone
- Your skin is sensitive, reactive, or rosacea/redness-prone
- You're maintaining results after a 6β12 week INTENSE Serum protocol
- You want a fragrance-free, oil-free, barrier-supporting "glow" serum
β Consider alternatives if:
- You're on a tight budget ($258 is a premium investment)
- You're pregnant or breastfeeding and want to avoid growth factors
- You follow a strictly vegan/plant-only routine
- You have deep, stubborn wrinkles needing the stronger INTENSE Serum
- You want a single product that replaces SPF or heavy moisturizer
π― Skin Type Compatibility
Oil-free, lightweight fluid that absorbs fast and adds glow without greasiness or clogged pores.
Glycerin-rich and hydrating, but very dry skin will want a richer moisturizer layered on top.
Balances hydration and renewal across both oily and dry zones for an even, healthy finish.
Fragrance-free, allergen-free and clinically calming β a standout for redness and rosacea-prone skin.
Non-comedogenic and fungal-acne friendly; also valued for fading the look of acne scarring over time.
Targets fine lines, firmness, and brown spots; ideal for daily maintenance of regenerative results.
π Results Timeline
Calmer, more hydrated skin
Many users report visibly reduced redness, a softer feel, and a fresh, dewy hydration boost early on.
Early respondersVisible clinical improvement
The Mayo Clinic POSH study recorded statistically significant gains in redness, brown spots, wrinkles, color evenness, and luminosity by six weeks.
98% would continueTone & texture transformation
A 2023 clinical study reported improvements in redness, irritation, tone, texture, and smoothness for the full panel by week nine.
100% improvedSustained renewal
With continued daily use, most participants saw lasting improvement in facial aging, including reduced pigmentation and sun damage.
87.3% improvedβ Ratings by Platform
βοΈ Pros & Cons
β Praised
- Genuine, peer-reviewed clinical backing from Mayo Clinic scientists
- Gentle yet effective β calms redness without irritation
- Fast-absorbing, fragrance-free, oil-free dewy finish
- Visibly improves tone, texture, fine lines, and brown spots
- Shelf-stable (no fridge) with eco-friendly refillable packaging
β Criticized
- Expensive β a significant investment per bottle
- Small 30 ml bottle / roughly 30β50 day supply
- Not vegan (human platelet extract + hydrolyzed gelatin)
- Requires regular exfoliation to avoid dullness
- Sold mainly direct or via aesthetic providers, not big-box retailers
π° Budget-Friendly Alternatives (Dupes)
Peptide- and HA-driven anti-aging at a fraction of the cost. No exosomes or growth factors and far less clinical depth, but a solid entry-level option for fine lines and hydration.
Uses a barley-derived EGF (single growth factor) rather than a full exosome complex. Regenerative and well-studied, but a narrower mechanism than platelet-derived exosomes.
Delivers stem-cell conditioned media (cord-lining derived) for renewal. Comparable regenerative goal, but a different biological source and less data than Plated's platelet exosomes.
π Comparison with Competitors
Plated DAILY Serum (Featured)
$258.00SkinMedica TNS Advanced+ Serum
$295.00BIOEFFECT EGF Serum
$160.00Calecim Professional Multi-Action
$190.00π¦ Storage & Shelf Life
6 months after opening (use within the 30β50 day supply for best potency)
Store at room temperature, away from direct sunlight. No refrigeration needed; stable up to 18 months unopened.
Airless refillable pump with reusable bottle and eco-friendly refill cartridges
Yes β 30 ml is well under the 100 ml carry-on limit
β Frequently Asked Questions
The formula contains no retinoids, salicylic acid, hydroquinone, or chemical sunscreens, which is reassuring. However, its key actives are platelet-derived exosomes and growth factors, which have not been well studied in pregnancy or breastfeeding. Because of this theoretical gap, dermatologists generally advise caution. Please consult your OB-GYN or dermatologist before using it while pregnant or nursing.
Yes, largely. The serum contains no oils, esters, fatty acids, or polysorbates that typically feed malassezia. The only flagged ingredient, arginine, is associated with fungal acne only when combined with lipids β which are absent here. Most fungal-acne-prone users tolerate it well, but as always, patch test first.
Yes. The brand confirms it can be layered with other actives, including retinoids. Apply Plated first on clean dry skin, let it dry for about 5 minutes, then apply your retinol, vitamin C, niacinamide, or exfoliating acids. Because exosomes speed up cell turnover, regular gentle exfoliation actually helps keep skin from looking dull.
It's formulated for all skin types β dry, normal, oily, combination, and sensitive. It's especially loved by those with redness, rosacea-prone, or reactive skin thanks to its calming, fragrance-free profile, and by anyone with mild-to-moderate signs of aging wanting an everyday "glow" serum.
Many users notice calmer, more hydrated skin within the first one to two weeks. Clinical studies recorded statistically significant improvements in redness, wrinkles, and brown spots by six weeks, with continued gains through 12 weeks and beyond when used consistently every day.
It goes FIRST, immediately after cleansing (and toner, if you use one), on clean dry skin before all other products. Let it absorb and dry fully for about 5 minutes, then follow with your other serums, moisturizer, and SPF.
No. It's oil-free, silicone-free, and rates very low on the comedogenic scale (about 1 out of 5). The lightweight, fast-absorbing texture is non-comedogenic and suitable for acne-prone and breakout-prone skin.
Use it within about 6 months of opening for peak potency. Unopened, it stays shelf-stable at room temperature for up to 18 months β no refrigeration required. Since a 30 ml bottle is roughly a 30β50 day supply, most people finish it well within the PAO window.
Verdict: Plated Skin Science DAILY Serum is one of the most credible exosome serums on the market β genuinely backed by Mayo Clinic research and peer-reviewed clinical data, not just marketing. It earns top marks for visibly calming redness, boosting glow, and gently improving tone and texture across all skin types, including sensitive and rosacea-prone skin. The main drawbacks are the premium price, small bottle, and non-vegan formula. If you want everyday, science-led anti-aging and your budget allows, it's a standout investment in long-term skin health.
Product Overview
What are Quick Product Notes?
Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.
Pro Tip Alert!
Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.
Quick Product Notes
Paraben-Free
Paraben-Free
Understanding Parabens
Parabens are a large group of preservatives which are used to prevent bacteria growing in cosmetic formulations. There has been some healthy controversy surrounding them due to a few studies finding paraben presence in breast tumours and breast tissue. However, the majority of the scientific community have deemed these findings non-conclusive due to the limitations of these studies. There's still a lot of support for avoiding parabens following the better safe than sorry route. If you do we completely support you! If you are concerned about the health safety of parabens, then feel free to avoid them by looking out for the Paraben-Free icon. If not, don't worry about it - they do have had one of the longest safety records as preservatives!
Which Ingredients are classified as Paraben?
A product will be paraben-free if it does not contain any of the following parabens:
- Sodium Isobutylparaben
- Sodium Ethylparaben
- Sodium Butylparaben
- Propylparaben
- Isopropylparaben
- Isobutylparaben
- Sodium Propylparaben
- Butylparaben
- Ethylparaben
- Sodium Methylparaben
- Methylparaben
Sulfate-Free
Sulfate-Free
Understanding Sulfates
Sulfates are a large group of ingredients which act as cleansing agents in Cosmetics. They help loosen up the dirt and grime from your skin and hair to allow for water to wash it away with ease. However some sulfates are so good at their job, they can wash off your skinβs own natural oils that keep it moisturised and protected which can lead to dryness and irritation. Most people will find no issues with sulfate, however if you find your skin doesn't like sulfates then free feel to avoid them by looking out for the sulfate-free icon on Skincarisma.
Which ingredients are classified as sulfates?
We've taken the Sulfates which are considered more harsh for our Sulfate-Free status. A product will be Sulfate-Free if it does not contain any of the following Sulfates:
- TEA-Dodecylbenzenesulfonate
- Ammonium Laureth Sulfate
- Sodium Lauryl Sulfate
- PEG-15 Cocamine
- Sodium Laureth Sulfate
- Sodium Cocoyl Sarcosinate
- Sodium C14-16 Olefin Sulfonate
- Dioctyl Sodium Sulfosuccinate
- Ammonium Xylenesulfonate
- Ammonium Lauryl Sulfate
- Sodium Xylenesulfonate
- Sodium Myreth Sulfate
- Sodium Lauryl Sulfoacetate
Alcohol-Free
Alcohol-Free
Understanding Simple Alcohols
Alcohol ingredients are widely used in cosmetics and come in different types. For the most part alcohols are not problematic at all. However one type of alcohols, simple alcohols can be quite drying to the skin because it evaporates very quickly. This can cause irritation which can also lead to other skin complications. These alcohols should never be used alone on your skin, but combined with other cosmetic ingredients, they are normally without issue. However, for some people with sensitive and easily irritable skin, avoiding products with these simple alcohols may be beneficial. If you find your skin doesn't like these simple alcohols, then free feel to avoid them by looking out for the Alcohol-Free icon.
Which Ingredients are classified as Alcohol?
A product will be alcohol-free if it does not contain any of the following alcohol ingredients:
- SD Alcohol
- Alcohol Denat
- Isopropyl Alcohol
- Alcohol
Silicone-Free
Silicone-Free
Understanding Silicones
If you've ever used a skincare, makeup or beauty product that's made your skin look and feel smoother tempoarily - it's likely contained Silicone. They are a popular class of ingredients found in cosmetics due to their smooth, soft, easy-to-spread and smooth properties that help creates an artificial layer/barrier on top of skin or hair (commonly found in conditioners).
For the same reasons they are popularly used, they are also commonly avoided. Anecdotally, many individuals have reported that Silicones cause/excerbate breakouts, irritation, cause a feeling of skin being unable to breathe, cause clumping of cosmetic products and find it difficult to wash off. As a result, those who find them problematic are avoiding them and increasingly, cosmetic companies are avoiding them as well.
If you have had bad experiences with Silicones in the past, or suspect they are problematic then look out for the tick on the Silicone-free label.
Disclaimer
The Silicone-free label only includes the most common Silicone ingredients that have indentified been reported by individuals that could potentially cause issues.
These include: Amodimethicone, Behenoxy Dimethicone, Bis-Aminopropyl Dimethicone, Cetearyl Methicone, Cetyl Dimethicone, Cyclomethicone, Cyclopentasiloxane, Dimethicone, Dimethicone Copolyol, Dimethiconol, Methicone, Phenyl Trimethicone, Phenyl Trimethicone, Stearoxy Dimethicone, Stearyl Dimethicone, Trimethylsilylamodimethicone.
Note, that this does not include all ingredients part of the Silicone class of ingredients.
EU Allergen-Free
EU Allergen-Free
Understanding the Identified Contact Allergens
The EU's Scientific Committee on Consumer Safety (SCCS) has identified and established 26 cosmetic ingredients that are likely contact allergens (potential to cause skin allergies) as demonstrated in clinical or epidemiological studies. The EU's SCCS have recommend cosmetic companies to disclose them on the labels if used and in cases where the concentration exceeds 0.001% in leave-on products and 0.01% in rinse-off products, then they must be labelled.
Look out for the tick on the EU-Allergen free label to know your cosmetic is free from any of the 26 identified cosmetic ingredients.
For more information regarding the EU's Scientific Committee on Consumer Safety, please visit their official website.
Disclaimer
The EU Allergen Free label is for the 26 ingredients identified by the EU SCCS and products will be only flagged if a suspected ingredient is on it's ingredient list. It is possible for cosmetics to contain one of the suspect ingredients without it appearing on the ingredient list due to it not reaching the concentration threshold to disclose it and cosmetic manufacturers choice to not disclose it.
Also note, the EU Allergen Free label is not personalized for your own allergies you may have and it does not constitute as medical advice. For your specific case, always consult your medical professiona such as dermatologist, physician, pharmacist, or health care provider - please read our medical disclaimer for more information.
Fungal Acne (Molassezia) Safe
Fungal Acne (Molassezia) Safe
Understanding Fungal Acne (Pityrosporum Folliculitis/Malassezia Folliculitis)
Pityrosporum Folliculitis/Malassezia folliculitis or simply known as Fungal Acne is a persistent acne-like condition that commonly responds poorly to traditional acne-treating methods. Unlike most cases of Acne where bacteria is the culprit, Fungi is the culprit of Fungal Acne (Hence the name!). There are certain classes & groups of ingredients that have been shown to promote and feed the growth of the Fungal Acne, Fungi such as fatty acids, oils, esters, polysorbates and fermented ingredients.
For more information regarding Fungal Acne, please visit Simple Skincare Science (f.c) - #3 of our Recommend Skincare Resources for an amazing comprehensive guide!
Please Read: How to use the Fungal Acne (Malassezia) Label
At SkinCarisma, we've done our best to identify as many ingredients as possible but note the fungal-free label may not be 100% accurate due to the complexconditions and combination of ingredients that malezzeria can thrive on.
Additionally, products that may contain ingredients that have shown to feed Malassezia may not neccessarily exacerbate the condition due to concentration of ingredient used in the product, this information is simply not available on the products.
As a result, please note this is only an experimental label that can be best used to possible identify problematic products you have used in the past. It is in no way a perfect identifier nor a predictor in whether or not it will exacerbate or cause fungal acne. It will continue to be worked on as more information and research comes to light.
If you find any ingredients you believe should be included, please email us at snails@skincarisma.com.
Disclaimer
Due to the lack of substantial research into this area it is very likely there are other ingredients and class/groups of ingredients that could feed Fungal Acne which have not been indentified.
The Fungal-Safe label does not constitute as medical advice. For your specific case, always consult your medical professiona such as dermatologist, physician, pharmacist, or health care provider - please read our medical disclaimer for more information.
What are Notable Effects & Ingredients?
Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging Β«promisesΒ» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.
We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.
Pro Tip Alert!
Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.
Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you
Notable Effects & Ingredients
Brightening from 1 ingredient(s):
Promotes Wound Healing from 2 ingredient(s):
What are Ingredients Related to Skin Type?
Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.
We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.
Pro Tip Alert!
A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.
One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!
Ingredients Related to Skin Types
Dry Skin
Oily/Acne-Prone Skin
Sensitive Skin
What is the Ingredient Safety Breakdown?
Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.
Pro Tip Alert!
EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.
Ingredient Safety Breakdown
Product ingredient list
| EWG | CIR | Ingredient Name & Cosmetic Functions | Notes |
|---|---|---|---|
| 1 |
Water
Solvent, Skin Conditioning
|
|
|
| 2 |
Glycerin
Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant, Skin Conditioning
|
Brightening
Promotes Wound Healing
Hydrating
|
|
| 1 |
Pentylene Glycol
Solvent, Skin Conditioning
|
|
|
| 1 |
Polyacrylate Crosspolymer-6
Viscosity Controlling, Emulsion Stabilising
|
|
|
| 0 |
Human Platelet Extract
Skin Conditioning
|
|