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Effaclar H Iso-Biome Moisturiser

Effaclar H Iso-Biome Moisturiser

Product Description

A microbiome-powered, ultra-lightweight moisturiser formulated for oily and acne-prone skin fragilised by drying treatments. Enriched with prebiotic Aqua Posae Filiformis, Niacinamide, Squalane, and Vitamin B5, it intensely hydrates while soothing redness and visibly reducing blemish marks β€” leaving skin comfortable and shine-free for up to 48 hours.

πŸ‡«πŸ‡· French Pharmacy Β· Made in France
βœ” Dermatologist Tested βœ” Non-Comedogenic βœ” Physiological pH βœ” Prebiotic Microbiome Formula βœ” Alcohol-Free βœ” For Oily & Acne-Prone Skin βœ” 48H Hydration Claim βœ” Parabens-Free
Pregnancy Safe
Caution ⚠️
Fungal Acne Safe
No βœ—
Comedogenic Rating
2/5
πŸ“¦
Size
40 ml
🎯
Skin Type
Oily / Acne-Prone
βš—οΈ
pH Level
Physiological
🌿
Vegan
No
🐰
Cruelty-Free
No

✨ Texture & Feel

πŸ’§
Consistency
Ultra-Fine Cream
πŸ‘ƒ
Scent
Light Fragrance
⏱️
Absorption
~30 Seconds
🎯
Finish
Natural / Dewy
🦠

Prebiotic Microbiome Technology

Aqua Posae Filiformis (Vitreoscilla Ferment), La Roche-Posay's exclusive prebiotic biomass, reinforces the skin's natural microbiome to strengthen the barrier and resist external aggressors.

✨

Niacinamide for Blemish Reduction

Clinically proven niacinamide (~2%) visibly reduces redness, post-acne marks, and uneven skin tone while supporting the skin barrier β€” without irritating fragile, treatment-stressed skin.

πŸ’¦

Squalane + Vitamin B5 Deep Hydration

Skin-identical squalane locks in moisture while panthenol (Pro-Vitamin B5) attracts water and promotes the skin's own lipid production β€” delivering clinically observed 48-hour hydration.

🌿

Bixa Orellana (Annatto) Seed Extract

This unique botanical extract from the achiote plant helps reduce visible imperfections and post-acne marks, offering a compensating anti-blemish action without drying or irritating the skin.

πŸ’Ž

La Roche-Posay Thermal Spring Water

Sourced from La Roche-Posay in France, the thermal spring water is naturally rich in selenium and has been used in dermatology for over 50 years to soothe reactive, sensitive skin conditions.

πŸ›‘οΈ

Non-Greasy Compensating Formula

Specifically designed to counteract the over-drying effects of acne treatments like isotretinoin, benzoyl peroxide, and strong exfoliants β€” replenishing moisture without adding shine or heaviness.

πŸ›‘οΈ Safety & Compatibility

⚠️
Pregnancy & Breastfeeding β€” Caution

The formula contains no retinoids, salicylic acid, or hydroquinone, which is reassuring. However, it does contain Parfum (fragrance), which some healthcare professionals advise minimising during pregnancy. Generally considered low-risk, but consult your OB-GYN or midwife before use.

❌
Fungal Acne (Malassezia) β€” Not Safe

This product contains Vitreoscilla Ferment (a fermented ingredient), as well as several fatty acid esters (Myristyl Myristate, Glyceryl Stearate SE) and fatty acids (Palmitic Acid, Stearic Acid, Myristic Acid) that can feed Malassezia yeast. Not recommended for fungal acne sufferers.

⚠️
Comedogenic Rating β€” 2/5 (Low–Moderate)

Most ingredients are non-comedogenic (glycerin, squalane, niacinamide, panthenol). However, Myristyl Myristate has a high individual comedogenicity score (5/5), which may cause congestion for some. The brand markets it as non-comedogenic β€” individual reactions may vary.

βœ…
Alcohol-Free

Contains no drying or irritating alcohols (no denatured alcohol, SD alcohol, or isopropyl alcohol). Safe for dry, sensitised, and compromised skin barrier conditions.

βœ…
Parabens-Free & Sulfates-Free

Free from parabens (traditional preservatives) and sulfate-based surfactants. Uses Hydroxyacetophenone and Caprylyl Glycol as mild, modern preservative alternatives.

βœ…
Retinoid-Free

Contains no retinol, retinaldehyde, or prescription retinoids. Perfectly safe to use alongside retinoid treatments as a compensating, soothing moisturiser to offset dryness and irritation.

ℹ️
Fragrance Present (Parfum)

The full INCI list includes Parfum/Fragrance as the last ingredient, indicating a very low concentration. Most users report the scent is barely perceptible, but those with fragrance sensitivity or contact allergy should patch test first.

βœ…
Compatible with Acne Treatments

Specifically formulated to be used alongside isotretinoin (Roaccutane/Accutane), benzoyl peroxide, adapalene, and other drying acne treatments. Clinically tested on skin undergoing such treatments under dermatological control.

πŸ”¬ Ingredient Breakdown

πŸ’§ Glycerin ~5–10% Proven

A skin-identical humectant appearing as the second ingredient, glycerin is one of the most well-researched moisturising actives in dermatology. It draws water from the environment and deeper skin layers into the stratum corneum, providing immediate and lasting hydration.

  • Function: Humectant, skin-identical ingredient, moisture-binding
  • Science: Demonstrated to increase skin hydration, improve barrier function, and accelerate stratum corneum repair in multiple peer-reviewed studies
  • Comedogenic Rating: 0/5 β€” universally non-comedogenic
βœ…
Safe for all skin types including sensitised, compromised, and pregnancy skin. An essential workhorse of effective moisturisation.

✨ Squalane ~3–7% Proven

A skin-identical emollient derived from sugarcane or olives, squalane mimics the natural squalene produced by human sebaceous glands. It forms a light, non-occlusive barrier on the skin surface that reduces transepidermal water loss without clogging pores.

  • Function: Skin-identical emollient, antioxidant, TEWL reduction
  • Science: Research confirms squalane is non-irritating at all concentrations and provides antioxidant protection against oxidative stress
  • Comedogenic Rating: 1/5 β€” essentially non-comedogenic
⚠️
If derived from olive oil rather than sugarcane, squalane may contain trace impurities relevant to fungal acne (Malassezia). Look for sugarcane-derived squalane if you have FA concerns.

πŸ’Š Panthenol (Vitamin B5) ~1–3% Proven

Pro-Vitamin B5 is a multi-tasking superstar. In the skin, it converts to pantothenic acid and plays a critical role in wound healing, barrier repair, and anti-inflammatory response. It also stimulates the production of skin-strengthening lipids and promotes fibroblast proliferation.

  • Function: Humectant, soothing agent, barrier repair, wound-healing support
  • Science: A 2016 study in Skin Pharmacology and Physiology showed panthenol significantly reduces skin irritation caused by other formulation components. Studies also confirm its role in promoting lipid synthesis in keratinocytes.
  • Comedogenic Rating: 0/5
βœ…
Excellent soothing and healing ingredient β€” particularly valuable in a product designed for skin damaged by aggressive acne treatments.

🌟 Niacinamide (Vitamin B3) ~1.4–2.1% Proven

Niacinamide is one of the most clinically validated multifunctional actives in skincare. At the concentration present in this formula (~2%), it supports barrier repair, reduces inflammation, visibly fades post-acne marks, and helps regulate sebum production β€” without irritating compromised skin.

  • Function: Anti-blemish, skin-brightening, barrier repair, anti-inflammatory, cell-communicating
  • Science: Multiple RCTs confirm niacinamide reduces hyperpigmentation, sebum output, and inflammatory acne lesions. At 2%, it is effective for barrier support and tone-evening; concentrations of 4–6% are more potent for sebum control.
  • Estimated concentration: 1.40–2.10% (per WIMJ analysis)
⚠️
The ~2% concentration is effective for barrier and brightening but lower than what studies suggest for maximum sebum reduction. Those seeking stronger anti-acne action may benefit from a dedicated niacinamide serum (5–10%) layered underneath.

🦠 Vitreoscilla Ferment (Aqua Posae Filiformis) trace–1% Promising

La Roche-Posay's proprietary prebiotic active, derived from the Vitreoscilla filiformis bacteria found in the thermal spring water of La Roche-Posay. This fermented biomass acts as a prebiotic, selectively nourishing beneficial skin bacteria to help restore and maintain a healthy skin microbiome.

  • Function: Prebiotic, microbiome modulation, barrier strengthening
  • Science: Studies on Vitreoscilla Ferment demonstrate positive effects on microbiome diversity, reduction in Staphylococcus aureus colonisation, and improved skin hydration in atopic dermatitis subjects
  • Note: As a fermented ingredient, it is not considered safe for fungal acne (Malassezia folliculitis)
⚠️
Fermented ingredients can feed Malassezia yeast. If you have fungal acne or are prone to it, this ingredient makes the product unsuitable for your concerns.

🌺 Bixa Orellana (Annatto) Seed Extract trace Promising

Extracted from the seeds of the achiote plant (Bixa orellana), this botanical is rich in carotenoids including bixin and norbixin. La Roche-Posay incorporates it in the Effaclar range for its anti-sebum and anti-marks properties, helping to reduce the appearance of post-acne pigmentation and imperfections.

  • Function: Anti-sebum, anti-marks, antioxidant, skin-tone evening
  • Science: Early research suggests carotenoid-rich botanicals can reduce oxidative stress and support melanin regulation in post-inflammatory hyperpigmentation
βœ…
A gentle plant-based complement to niacinamide for reducing the appearance of residual acne marks. Concentrations in skincare are typically low but supportive.

25 ingredients

Aqua/Water, Glycerin, Squalane, Dimethicone, Panthenol, Zea Mays Starch/Corn Starch, Niacinamide, Ammonium Polyacryloyldimethyl Taurate, Myristyl Myristate, Bixa Orellana Seed Extract, Stearic Acid, Potassium Cetyl Phosphate, Glyceryl Stearate SE, Sodium Hydroxide, Myristic Acid, 2-Oleamido-1,3-Octadecanediol, Palmitic Acid, Hydroxyacetophenone, Capryloyl Glycine, Caprylyl Glycol, Vitreoscilla Ferment, Citric Acid, Maltodextrin, Xanthan Gum, Parfum/Fragrance

FREE FROM: Parabens Β· Drying alcohols (denat.) Β· Sulfates Β· Retinoids Β· Hydroquinone Β· Mineral oil Β· Chemical UV filters Β· Phthalates Β· Bisphenols Β· PFAS Β· Talc

πŸ”„ Where It Fits in Your Routine

1
Cleanser
2
Toner / Essence
3
Serum / Treatment
4
Effaclar H Iso-Biome ← Here
5
SPF (AM only)

Apply morning and evening after cleansing. During the day, always follow with a broad-spectrum SPF 30+. At night, apply after actives (retinoids, AHAs, benzoyl peroxide) to compensate for their drying effects.

πŸ“ How to Use

1

Cleanse Your Face

Start with a gentle, pH-balanced cleanser suited to your skin type. The Effaclar H Iso-Biome Cleansing Cream from the same range is an ideal companion, as it's formulated to work synergistically with this moisturiser.

2

Apply Toner or Treatment (Optional)

If you use a toner, essence, or targeted treatment serum (such as a niacinamide or azelaic acid serum), apply these to dry skin before the moisturiser. Allow each layer to absorb for 20–30 seconds.

3

Apply a Thin Layer of Effaclar H Iso-Biome

Dispense a pea-sized to dime-sized amount and spread evenly across the entire face, including the under-eye area if needed. Use gentle upward and outward strokes with your fingertips. There is no need to massage aggressively β€” the ultra-fine texture absorbs quickly.

4

Morning: Follow with SPF

In the morning, finish with a broad-spectrum sunscreen (SPF 30 or higher). This moisturiser does not contain UV filters, so sun protection is essential β€” particularly if you are using photosensitising acne treatments like retinoids or AHAs.

5

Use Twice Daily for Best Results

Apply every morning and evening consistently. Clinical testing of the Effaclar H range has been conducted with twice-daily use. Consistent application for at least 4 weeks is recommended to appreciate the full soothing and barrier-repair benefits.

πŸ‘€ Who Is It For?

βœ… Perfect for you if:

  • Your skin is oily or acne-prone and currently undergoing drying treatments (isotretinoin, benzoyl peroxide, strong retinoids, or prescription topicals)
  • Your skin feels tight, rough, or irritated after your acne skincare routine
  • You want a lightweight moisturiser that won't undo your acne-fighting efforts
  • You're dealing with post-acne redness or lingering blemish marks
  • You need a moisturiser that layers seamlessly under SPF without pilling
  • You prefer French pharmacy dermocosmetics backed by clinical testing
  • You want prebiotic microbiome support for long-term skin health

❌ Consider alternatives if:

  • You have fungal acne (Malassezia folliculitis) β€” the ferment and fatty acid esters will likely trigger breakouts
  • You have very dry or dehydrated skin and need a richer, occlusive moisturiser
  • You are highly fragrance-sensitive β€” the formula does contain Parfum
  • You are seeking a fully vegan and cruelty-free option (the brand is not certified)
  • You need strong niacinamide action at 5–10% for sebum control
  • You have a known sensitivity or allergy to Myristyl Myristate

🎯 Skin Type Compatibility

Oily Skin β˜…β˜…β˜…β˜…β˜… Excellent

The ultra-fine, non-greasy texture was engineered specifically for oily skin fragilised by drying treatments. Absorbs in seconds without adding shine or heaviness β€” the ideal companion for oil-control routines.

Combination Skin β˜…β˜…β˜…β˜…β˜… Excellent

Balances beautifully across T-zone and drier cheek areas. Provides adequate hydration without overwhelming oilier zones β€” a versatile everyday option for combination skin.

Acne-Prone Skin β˜…β˜…β˜…β˜…β˜† Good

Excellent compensating moisturiser for skin stressed by acne treatments. Clinically tested under dermatological control. Note: Myristyl Myristate may cause congestion for a small subset of highly acne-prone individuals β€” patch test first.

Sensitive / Reactive Skin β˜…β˜…β˜…β˜…β˜† Good

Formulated with a physiological pH and soothing actives (panthenol, thermal spring water, glycerin). However, the presence of fragrance means those with fragrance sensitivity should patch test before committing to full use.

Dry Skin β˜…β˜…β˜…β˜†β˜† Moderate

The lightweight texture may not provide sufficient occlusion for very dry or severely dehydrated skin. Those with dry skin may find it works better as a day cream layered under a richer night cream, rather than as a standalone moisturiser.

πŸ“ˆ Results Timeline

Days 1–3

Immediate Soothing & Comfort

Skin feels less tight, dry, and irritated almost immediately. Glycerin and panthenol deliver rapid relief from the discomfort caused by drying acne treatments. The ultra-fine texture absorbs cleanly without the sticky or greasy residue common in richer creams.

~90% noticed soothing relief
Week 1–2

Improved Skin Comfort & Reduced Tightness

Consistent twice-daily application restores baseline hydration. Skin texture begins to smooth out; patches of flakiness from retinoid or benzoyl peroxide use become less visible. The barrier begins to recover from treatment-induced compromise.

~75% reported improved comfort
Week 3–4

Visible Reduction in Redness & Dryness

Niacinamide and the prebiotic complex begin to show more visible skin-calming effects. Redness and irritation decrease noticeably. A clinical study on the Effaclar H range recorded a 64% reduction in skin dryness scores after 4 weeks of use.

~64% reduction in dryness (clinical)
Week 6–8

Post-Acne Marks Fading

With consistent use, the combined action of niacinamide and Bixa Orellana extract begins to visibly lighten post-acne erythema (red marks) and hyperpigmentation. Skin tone appears more even. Pore appearance may look refined thanks to better sebum regulation.

~60% noticed improved skin tone
Month 3+

Microbiome Rebalancing & Long-Term Barrier Strength

Aqua Posae Filiformis (Vitreoscilla Ferment) works cumulatively to strengthen the skin microbiome, leading to more resilient skin that's less reactive and better equipped to handle ongoing acne treatments. Overall skin comfort and health improve significantly.

~70% reported long-term skin resilience

⭐ Ratings by Platform

🏠 Boots UK (Brand Retailer)
β˜…β˜…β˜…β˜… 3.7
Rating
199+
Reviews
⚠️ Main complaint: 40ml feels small for the price; some users found it insufficient for very dry skin and needed a heavier cream on top.
πŸ’„ Cult Beauty
β˜…β˜…β˜…β˜… 4.2
Rating
80+
Reviews
⚠️ Main complaint: Some customers noted minimal visible difference for those not using drying acne treatments β€” the product's true benefit is compensating context-specific use.
🏠 La Roche-Posay Website
β˜…β˜…β˜…β˜… 4.0
Rating
500+
Reviews
⚠️ Main complaint: A subset of users on Isotretinoin reported needing to layer it with a richer cream at night for adequate moisture during peak treatment dryness.
🌿 WIMJ / Skincare Analysis
β˜…β˜…β˜…β˜…β˜… 100
Promises Fulfilled
Medium
Irritation Potential
⚠️ Expert note: WIMJ's science-based review scores Promises Fulfilled at 100/100 but rates irritation potential as medium, primarily due to fragrance and Myristyl Myristate.

βš–οΈ Pros & Cons

βœ… Praised

  • Ultra-lightweight, non-greasy texture ideal for oily skin
  • Absorbs fast β€” no sticky or heavy residue
  • Genuinely soothes skin stressed by acne treatments
  • Clinically proven 64% reduction in dryness in 4 weeks
  • Prebiotic Aqua Posae Filiformis for microbiome health
  • Physiological pH β€” kind to the skin barrier
  • Effectively reduces post-acne redness (niacinamide)
  • Layers beautifully under SPF without pilling
  • Free from parabens, harsh alcohols, and sulfates
  • Dermatologically tested on acne treatment skin

❌ Criticized

  • Small 40ml tube feels insufficient for the price
  • Contains Parfum (fragrance) β€” not truly fragrance-free
  • Not safe for fungal acne (Malassezia folliculitis)
  • Myristyl Myristate may cause congestion for some users
  • Niacinamide at ~2% is lower than the 5–10% clinical range for sebum control
  • Not vegan; not cruelty-free certified
  • May not provide enough moisture for very dry or severely compromised skin
  • Limited availability in the USA (mainly via international or French pharmacy retailers)

πŸ’° Budget-Friendly Alternatives (Dupes)

75% Match
Neutrogena Hydro Boost Oil-Free Gel-Cream for Oily Skin
~$14.00 Budget Pick

Shares the lightweight gel-cream texture and non-greasy finish. Key humectants include hyaluronic acid rather than glycerin + panthenol. Lacks Effaclar H's prebiotic complex and niacinamide, but delivers excellent oil-free hydration for acne-prone skin at a fraction of the cost. Widely available. Not FA-safe either.

70% Match
CeraVe PM Facial Moisturizing Lotion
~$16.00 Budget Pick

Contains niacinamide (4%), hyaluronic acid, and three essential ceramides β€” arguably stronger barrier repair than Effaclar H. The MVE (MultiVesicular Emulsion) technology provides sustained release of actives. However, it lacks the prebiotic technology and Bixa Orellana extract. Fragrance-free β€” better choice for fragrance-sensitive users.

60% Match
Paula's Choice RESIST Anti-Aging Clear Skin Hydrator
~$30.00 Similar Price

A lightweight serum-moisturiser hybrid for acne-prone skin. Contains niacinamide, glycerin, and soothing agents. Well-formulated and fragrance-free, but heavier texture and higher price than Effaclar H. No prebiotic component. Better suited to those who want zero fragrance and a brand with transparent formulation philosophy.

πŸ”„ Comparison with Competitors

Bioderma SΓ©bium Hydra Compensating Moisturiser

~Β£15 / ~$19
Key Actives Fluidactiv, Zinc, Niacinamide
Size 40 ml
Texture Rich cream
Prebiotic Technology No
Fragrance-Free Yes
Fungal Acne Safe No
Comedogenic Rating 2/5
Dermatologist Tested Yes

Avène Cleanance Hydra Soothing Cream

~Β£16 / ~$20
Key Actives Avène Thermal Spring Water, Glycerin
Size 40 ml
Texture Light cream
Prebiotic Technology No
Fragrance-Free Yes
Fungal Acne Safe No
Comedogenic Rating 1/5
Dermatologist Tested Yes

Neutrogena Hydro Boost Gel-Cream (Oil-Free)

~Β£12 / ~$14
Key Actives Hyaluronic Acid, Glycerin
Size 50 ml
Texture Water-gel, ultra-light
Prebiotic Technology No
Fragrance-Free Yes
Fungal Acne Safe Varies by region
Comedogenic Rating 1/5
Dermatologist Tested Yes

πŸ“¦ Storage & Shelf Life

πŸ“…
Period After Opening (PAO)

12 months after opening. Look for the open jar symbol on the packaging confirming this. Use the product within 12 months of first opening for optimal efficacy and safety.

🏠
Storage

Store at room temperature (below 25Β°C / 77Β°F), away from direct sunlight, heat sources, and humidity. Do not refrigerate unless advised on packaging β€” extreme cold can affect the emulsion texture.

πŸ“¦
Packaging

Comes in a 40ml aluminium or plastic tube with a screw cap. The tube format is hygienic (minimises product-air contact) and allows controlled dispensing of the amount needed per application.

✈️
Travel Friendly

Yes β€” at 40ml, it is well within the 100ml liquid limit for carry-on baggage on most airlines (EU, UK, US TSA standards). Place in your clear toiletry bag for security checks.

❓ Frequently Asked Questions

Generally considered low-risk during pregnancy and breastfeeding, as it contains no retinoids, salicylic acid, hydroquinone, or chemical UV filters β€” the four main categories of skincare ingredients typically restricted during pregnancy. However, it does contain Parfum (fragrance), which some healthcare professionals advise minimising as a precaution. The fragrance is listed as the last ingredient, indicating a very low concentration. We always recommend consulting your OB-GYN, midwife, or dermatologist before introducing any new skincare product during pregnancy or breastfeeding.

No β€” this product is not considered safe for fungal acne (Malassezia folliculitis). It contains several ingredients that can feed Malassezia yeast, including Vitreoscilla Ferment (a fermented ingredient), Myristyl Myristate, Glyceryl Stearate SE (esters), and fatty acids including Palmitic Acid, Stearic Acid, and Myristic Acid. If you are dealing with fungal acne, look for a moisturiser that is explicitly fungal-acne safe, such as one formulated without ferments, fatty acid esters, and long-chain fatty acids.

Yes β€” and in fact, this moisturiser was specifically designed to be used alongside such actives. It is an ideal compensating moisturiser for skin that has become dry, irritated, or sensitised from retinoids (retinol, tretinoin, adapalene), chemical exfoliants (AHAs like glycolic and lactic acid, BHAs like salicylic acid), benzoyl peroxide, or other potent acne treatments. Apply your active treatments first and allow them to absorb, then apply Effaclar H Iso-Biome on top. In the morning, always follow with SPF β€” especially if you are using photosensitising actives.

It is best suited to oily and acne-prone skin types, particularly those currently undergoing drying acne treatments (isotretinoin, benzoyl peroxide, retinoids, prescription topicals). Combination skin types also respond very well to its balancing formula. It is suitable for sensitive skin as long as fragrance is not a trigger. Those with very dry skin may find it provides insufficient moisture as a standalone product and may need to layer it under a richer night cream. It is not recommended for those with fungal acne.

Soothing and comfort benefits are typically felt within the first 1–3 days of use. Visible reduction in redness, dryness, and irritation is generally reported within 1–2 weeks. Clinical testing on the Effaclar H range demonstrated a 64% reduction in skin dryness scores after 4 weeks of consistent twice-daily use. Improvements in post-acne marks and skin tone become more noticeable from weeks 6–8 onwards, as niacinamide and the Bixa Orellana extract work cumulatively. For microbiome rebalancing, the full benefit is seen after 2–3 months of consistent use.

Effaclar H Iso-Biome Moisturiser is applied as the final step before sunscreen in your AM routine. In your PM routine, it is the last step overall (unless you apply a facial oil on top). The correct order is: Cleanser β†’ Toner or Essence (optional) β†’ Serum or Treatment (retinoid, vitamin C, AHA/BHA, etc.) β†’ Effaclar H Iso-Biome Moisturiser β†’ SPF (morning only). Apply to dry skin and allow to absorb before applying sunscreen to prevent pilling.

La Roche-Posay markets the product as non-comedogenic, and it has been clinically tested. The majority of ingredients are rated 0–1 on the comedogenicity scale (glycerin, squalane, panthenol, niacinamide, dimethicone). However, the formula does contain Myristyl Myristate, an emollient that carries an individual comedogenicity score of 5/5 on some reference scales. In practice, comedogenicity is dose- and skin-dependent β€” many people with acne-prone skin use this product without experiencing breakouts. We assign it an overall rating of 2/5, and always recommend patch testing on your jawline for 1–2 weeks before applying it to your entire face.

The Period After Opening (PAO) for Effaclar H Iso-Biome Moisturiser is 12 months, indicated by the open jar symbol on the packaging. With twice-daily use (a pea-sized to dime-sized amount per application), the 40ml tube typically lasts approximately 6–8 weeks of consistent use, well within the 12-month PAO window. Store at room temperature, away from heat and direct sunlight, to maintain formula stability and efficacy throughout its lifespan.

β˜…β˜…β˜…β˜…β˜†
4.2 out of 5

Verdict: La Roche-Posay Effaclar H Iso-Biome Moisturiser is a standout compensating moisturiser for anyone whose skin is being compromised by heavy-duty acne treatments. Its prebiotic microbiome technology (Aqua Posae Filiformis), combined with squalane, niacinamide, and Vitamin B5, delivers science-backed relief and real, clinically measured results β€” a 64% reduction in dryness scores in just 4 weeks. The ultra-fine texture absorbs without greasiness, making it a reliable daily companion for oily and combination skin types. The main caveats β€” a compact 40ml size, the presence of fragrance, and fatty acid esters that disqualify it for fungal acne sufferers β€” keep it from a perfect score. But for its intended audience (oily, acne-prone skin fragilised by drying treatments), few French pharmacy moisturisers do the job as elegantly and effectively as this one.

Product Overview

question
lightbulb What are Quick Product Notes?

Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.

muscle Pro Tip Alert!

Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.

Awesome, I Understand!

Quick Product Notes

Click on icons for more information
question
lightbulb What are Notable Effects & Ingredients?

Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging Β«promisesΒ» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.

We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.

muscle Pro Tip Alert!

Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.

Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you

Awesome, I Understand!

Notable Effects & Ingredients

anti-aging Anti-Aging from 2 ingredient(s):
Niacinamide Citric Acid
brightening Brightening from 3 ingredient(s):
Glycerin Niacinamide Citric Acid
wound Promotes Wound Healing from 4 ingredient(s):
Glycerin Panthenol Niacinamide Citric Acid
ache Ache-fighting from 1 ingredient(s):
Niacinamide
question
lightbulb What are Ingredients Related to Skin Type?

Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.

We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.

muscle Pro Tip Alert!

A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.

One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!

Awesome, I Understand!

Ingredients Related to Skin Types

Click on icons for more information
dry-skin Dry Skin
2
oily-skin Oily/Acne-Prone Skin
2
sensitive-skin Sensitive Skin
question
lightbulb What is the Ingredient Safety Breakdown?

Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.

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EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.

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Ingredient Safety Breakdown

EWG Health Ratings
Low risk
Medium risk
High risk
Unknown risk
72% 8% 20%

Product ingredient list

Showing first 5 of 25 ingredients
EWG CIR Ingredient Name & Cosmetic Functions Notes
1 Unknown
Water
Solvent, Skin Conditioning
2 A
Glycerin
Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant, Skin Conditioning
brightening Brightening
Promotes Wound Healing
Hydrating
1 A
Squalane
Skin Conditioning, Emollient, Hair Conditioning, Refatting
Hydrating
3 A
Dimethicone
Skin Conditioning, Emollient, Antifoaming Agent, Skin Protecting
1 A
Panthenol
Skin Conditioning, Antistatic Agent, Hair Conditioning
Promotes Wound Healing
Hydrating
Redness
Irritation
VIEW ALL INGREDIENTS