EGF Serum
EGF Serum
Product Description
Product overview
A groundbreaking, award-winning biotech serum featuring plant-based Epidermal Growth Factor (EGF) produced in barley. This minimalist 7-ingredient formula targets visible signs of aging while enhancing hydration, supporting natural collagen production for smoother, firmer, and more youthful-looking skin.
Nobel Prize Research
Built on EGF discovery that earned a Nobel Prize in 1986. First plant-based EGF produced using advanced biotechnology in barley plants.
Texture & feel
SENSORYNobel Prize Research
Built on EGF discovery that earned a Nobel Prize in 1986. First plant-based EGF produced using advanced biotechnology in barley plants.
Minimalist Formula
Only 7 pure ingredients for maximum efficacy and minimal irritation risk. No fillers, fragrances, or unnecessary additives.
Collagen Support
Barley EGF helps support skin's natural collagen production for improved density, firmness, and reduced appearance of fine lines.
Sustainable Biotech
Produced in Iceland's geothermal greenhouse powered by renewable energy. Uses pure Icelandic water filtered through volcanic lava.
Safety & compatibility
SAFEContains no retinoids, salicylic acid, or other pregnancy-restricted ingredients. EGF is considered a safe retinol alternative during pregnancy.
Zero fungal acne triggers. Contains no ferments, problematic fatty acids, esters, or polysorbates that feed malassezia yeast.
Comedogenic rating 0/5. All ingredients (glycerin, hyaluronic acid, water) have zero comedogenic potential. Won't clog pores.
Fragrance-free, alcohol-free, and preservative-free. Minimal ingredient list reduces irritation risk. Patch test recommended for very reactive skin.
Contains barley-derived ingredients. Those with barley or gluten allergies should consult a dermatologist before use.
If you have a history of skin cancer, numerous moles, or excessive sun damage, consult your physician before using growth factor products.
Ingredient breakdown
INGREDIENTSBarley EGF (SH-Oligopeptide-1)Proven
The star ingredient - a plant-based replica of human Epidermal Growth Factor produced through advanced biotechnology in barley plants. This signaling protein helps stimulate cell renewal and supports natural collagen production.
- Nobel Prize: EGF discovery by Stanley Cohen earned the 1986 Nobel Prize in Physiology or Medicine
- Clinical Study: 63% reduction in appearance of wrinkles after 3 months of use (BIOEFFECT in-house study)
- Mechanism: Binds to EGF receptors to signal cell proliferation and wound healing processes
Sodium HyaluronateProven
The salt form of hyaluronic acid, known for its exceptional ability to hold up to 1,000 times its weight in water. Provides immediate and lasting hydration to plump and smooth skin.
- Hydration: Attracts and retains moisture in the skin's upper layers
- Plumping: Helps reduce the appearance of fine lines through hydration
- Compatibility: Naturally found in skin, excellent tolerability
GlycerinProven
A powerful humectant that draws moisture into the skin and helps maintain the skin's lipid barrier. Provides long-lasting hydration without heaviness.
- Study: More effective as a humectant than AHAs and hyaluronic acid alone (2016 research)
- Barrier Support: Helps maintain skin's natural moisture barrier
- Safety: Comedogenic rating 0, irritancy rating 0
Icelandic Water Base
Pure Icelandic water geologically filtered through layers of volcanic lava. Exceptionally soft and pure, free from hard minerals that can dry or irritate skin.
- Purity: Low concentration of calcium and magnesium for optimal skin compatibility
- Source: Naturally filtered through ancient lava fields in Iceland
Barley Seed ExtractPromising
Peptide-rich extract from barley that helps keep growth factors stable in the formula. Provides additional antioxidant and barrier-supporting benefits.
- Stability: Helps maintain EGF potency throughout product shelf life
- Antioxidant: Protects against UV radiation and environmental pollutants
7 ingredients
Glycerin, Water (Aqua), Sodium Hyaluronate, Tromethamine, Sodium Chloride, Barley (Hordeum Vulgare) Seed Extract, EGF (Barley SH-Oligopeptide-1)
Where it fits in your routine
ROUTINEApply to clean skin after toner. Wait 3-5 minutes before layering moisturizer or makeup. For best results, apply on slightly damp skin. Works well with the BIOEFFECT EGF Essence as a prep step.
How to use
HOW TO USECleanse & Prep
Start with freshly cleansed skin. For enhanced absorption, use a hydrating toner or the BIOEFFECT EGF Essence first.
Apply 2-4 Drops
Dispense 2-4 drops onto fingertips. A little goes a long way - using too much may cause stickiness.
Gently Press & Pat
Apply to face, neck, and décolleté using gentle upward motions. Pat gently to help absorption.
Wait Before Layering
Allow 3-5 minutes for full absorption before applying moisturizer, sunscreen, or makeup. Do not mix with other products immediately.
Who is it for?
WHOPerfect for you if:
- You want to target fine lines and wrinkles without using retinol
- You're pregnant or breastfeeding and need a safe anti-aging option
- You have sensitive skin and need a gentle, minimal formula
- You prefer clean, science-backed skincare with proven ingredients
- You have fungal acne and struggle to find safe anti-aging products
- You want to maintain youthful skin and prevent signs of aging
- You appreciate luxurious, high-quality skincare investments
Consider alternatives if:
- You're on a tight budget (this is a premium-priced product)
- You have a barley or gluten allergy
- You prefer rich, creamy textures over lightweight serums
- You have a history of skin cancer (consult doctor first)
- You want instant results (this works gradually over weeks)
- You dislike products with a slightly tacky feel during absorption
Skin type compatibility
SKIN TYPESHyaluronic acid and glycerin provide deep hydration. Works best when layered under a moisturizer to seal in benefits.
Lightweight, oil-free, water-based formula absorbs quickly without adding shine or greasiness to the skin.
Balances well across different face zones. Hydrates dry areas without overloading oily T-zone.
Fragrance-free, minimal ingredients make it highly tolerable. Patch test for 3 days recommended for very reactive skin.
Non-comedogenic (rating 0/5) and fungal acne safe. Oil-free formula won't trigger breakouts or clog pores.
Specifically designed to target signs of aging. EGF supports collagen production for improved firmness and density.
Results timeline
MONTH 3+Immediate Hydration Boost
Skin feels more hydrated and plump. Surface smoothing effect visible. Some users notice an immediate glow and improved skin texture.
85% noticed improved hydrationTexture Improvement
Skin texture becomes smoother and more refined. Fine lines appear softer. Overall radiance and evenness improve noticeably.
72% saw texture improvementVisible Wrinkle Reduction
Significant reduction in the appearance of fine lines and wrinkles. Skin looks firmer and more elastic. Clinical studies show up to 63% wrinkle reduction.
63% reduction in wrinkle appearanceLong-Term Transformation
Continued improvement in skin density and firmness. Up to 68% improvement in elasticity. Best results with consistent twice-daily use.
68% improved skin elasticityRatings by platform
2K+ REVIEWSPros & cons
BALANCEDPraised
- Award-winning, clinically-proven formula with visible results
- Minimal 7-ingredient formula reduces irritation risk
- Safe for pregnancy, breastfeeding, and fungal acne
- Fragrance-free and suitable for sensitive skin
- Lightweight, fast-absorbing texture
- Sustainable production using geothermal energy
- Excellent alternative to retinol without irritation
- Works well for all skin types including acne-prone
Criticized
- Premium price point (~$175 for 15ml)
- Can feel sticky if too much is applied
- Results take 4-8 weeks to become visible
- Small bottle size for the price
- Not hydrating enough alone for very dry skin
- Contains barley (not suitable for gluten allergies)
- Needs 3-5 minute wait time before layering
Budget-friendly alternatives (dupes)
DUPESFeatures 3 plant-based growth factors (EGF, IGF, TGF) at an unbeatable price. Lighter texture, similar goals. May not have the same bioavailability as BIOEFFECT's barley-derived EGF.
Combines plant-derived EGF with Vitamin C for brightening. Different formula focus but targets similar aging concerns at a fraction of the price.
Different active (snail mucin) but similar skin-regenerating and hydrating benefits. More hydrating texture. Budget-friendly K-beauty option for repair and renewal.
Vegan synthetic EGF in a booster format. Can be mixed into other products. Similar price tier with slightly different delivery system and formula.
Comparison with competitors
SIDE-BY-SIDE
SkinMedica TNS Advanced+ Serum
Storage & shelf life
12 MONTHS12 months after opening. Use consistently twice daily to finish within recommended timeframe.
Store at room temperature or below. Keep out of direct sunlight. Do not expose to extreme heat.
Airless pump dropper bottle. Preserves formula integrity and prevents contamination.
Yes, under 100ml/3.4oz TSA limit. Compact size perfect for travel skincare routines.
Frequently asked questions
FAQYes, BIOEFFECT EGF Serum is considered safe during pregnancy and breastfeeding. The formula contains no retinoids, salicylic acid, hydroquinone, or other pregnancy-restricted ingredients. EGF (Epidermal Growth Factor) is naturally present in the body and is considered a safe alternative to retinol during pregnancy. However, as with any skincare product, it's always recommended to consult with your healthcare provider before introducing new products during pregnancy or nursing.
Yes, BIOEFFECT EGF Serum is fungal acne safe with zero malassezia triggers. The formula contains no ferments, problematic fatty acids, esters, or polysorbates that can feed malassezia yeast. Its minimal 7-ingredient formula consisting of glycerin, water, sodium hyaluronate, tromethamine, sodium chloride, barley seed extract, and EGF is completely safe for those dealing with fungal acne.
Yes, EGF can be used alongside retinol, Vitamin C, and AHA/BHA acids. However, for best results, consider using them at different times of day: EGF in the morning, and stronger actives like retinol or acids in the evening. Some dermatologists suggest that using EGF after retinol can help soothe skin and enhance repair. Always wait for the serum to fully absorb (3-5 minutes) before layering other products.
BIOEFFECT EGF Serum is suitable for all skin types including dry, oily, combination, sensitive, acne-prone, and mature skin. Its lightweight, oil-free, water-based formula makes it particularly excellent for oily and combination skin, while the hyaluronic acid and glycerin provide adequate hydration for dry skin when layered under a moisturizer. The fragrance-free, minimal formula is ideal for sensitive skin types.
Most users notice improved hydration and a subtle glow within the first 1-2 weeks. Visible improvements in skin texture typically appear around weeks 3-4. Significant reduction in fine lines and wrinkles (up to 63%) is generally observed after 2-3 months of consistent twice-daily use. For best results, use morning and night for at least 3 months. Results are cumulative and improve with continued use.
Apply BIOEFFECT EGF Serum after cleansing and toning, before moisturizer. For optimal results: 1) Cleanse, 2) Apply toner or essence (optional - the BIOEFFECT EGF Essence works perfectly as prep), 3) Apply 2-4 drops of EGF Serum, 4) Wait 3-5 minutes for absorption, 5) Apply moisturizer, 6) Sunscreen (morning only). The serum can be used both morning and evening.
No, BIOEFFECT EGF Serum has a comedogenic rating of 0/5 and will not clog pores. All ingredients in the formula (glycerin, water, sodium hyaluronate, tromethamine, sodium chloride, barley seed extract, and EGF) have zero to negligible comedogenic potential. The oil-free, water-based formula is specifically designed to be non-pore-clogging and is safe for acne-prone skin.
BIOEFFECT EGF Serum should be used within 12 months after opening (PAO: 12M). The airless pump packaging helps preserve the formula's integrity and prevents contamination. For best results, use consistently twice daily - at this rate, a 15ml bottle typically lasts 2-3 months. Store at room temperature, away from direct sunlight and extreme temperatures.
Verdict: BIOEFFECT EGF Serum is a premium, science-backed anti-aging serum that delivers on its promises for those willing to invest. The Nobel Prize-winning research behind EGF, combined with a minimalist 7-ingredient formula, makes it ideal for sensitive skin types and those seeking a retinol alternative. While the price point is high, the clinically-proven results (up to 63% wrinkle reduction) and excellent safety profile for pregnancy, breastfeeding, and fungal acne sufferers justify the investment for many users. Best suited for those who prioritize clean formulations, gentle yet effective anti-aging, and sustainable biotech skincare.
Product Overview
Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.
Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.
Quick Product Notes
Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging «promises» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.
We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.
Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.
Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you
Notable Effects & Ingredients
Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.
We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.
A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.
One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!
Ingredients Related to Skin Types
Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.
EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.
Ingredient Safety Breakdown
Product ingredient list
| EWG | CIR | Ingredient Name & Cosmetic Functions | Notes |
|---|---|---|---|
| 2 |
Glycerin
Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant, Skin Conditioning
|
Promotes Wound Healing
Hydrating
|
|
| 1 |
Water
Solvent, Skin Conditioning
|
|
|
| 1 |
Sodium Hyaluronate
Skin Conditioning, Humectant
|
Promotes Wound Healing
Hydrating
|
|
| 0 |
Tromethamine
|
|
|
| 1 |
Sodium Chloride
Masking, Viscosity Controlling, Bulking Agent
|
|






