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EGF Serum

EGF Serum

Product Description

Product overview

Made in Various INTERNATIONAL

A groundbreaking, award-winning biotech serum featuring plant-based Epidermal Growth Factor (EGF) produced in barley. This minimalist 7-ingredient formula targets visible signs of aging while enhancing hydration, supporting natural collagen production for smoother, firmer, and more youthful-looking skin.

Fragrance-Free Oil-Free Alcohol-Free Paraben-Free No Preservatives Fungal Acne Safe Pregnancy Safe All Skin Types Nobel Prize Research
Pregnancy
Yes
Fungal Acne
Yes
Comedogenic
0/5
Size
15ml / 30ml
Formula
Water-Based
Concern
Anti-Aging
Use
AM & PM
Key Active
Barley EGF
Real reviews · YouTube Shorts
Why it's different

Nobel Prize Research

Built on EGF discovery that earned a Nobel Prize in 1986. First plant-based EGF produced using advanced biotechnology in barley plants.

01

Texture & feel

SENSORY
Consistency
Lightweight Gel
Scent
Fragrance-Free
Absorption
30-60 seconds
Finish
Dewy Hydrated

Nobel Prize Research

Built on EGF discovery that earned a Nobel Prize in 1986. First plant-based EGF produced using advanced biotechnology in barley plants.

Minimalist Formula

Only 7 pure ingredients for maximum efficacy and minimal irritation risk. No fillers, fragrances, or unnecessary additives.

Collagen Support

Barley EGF helps support skin's natural collagen production for improved density, firmness, and reduced appearance of fine lines.

Sustainable Biotech

Produced in Iceland's geothermal greenhouse powered by renewable energy. Uses pure Icelandic water filtered through volcanic lava.

02

Safety & compatibility

SAFE
Pregnancy & Breastfeeding Safe

Contains no retinoids, salicylic acid, or other pregnancy-restricted ingredients. EGF is considered a safe retinol alternative during pregnancy.

Fungal Acne (Malassezia) Safe

Zero fungal acne triggers. Contains no ferments, problematic fatty acids, esters, or polysorbates that feed malassezia yeast.

Non-Comedogenic

Comedogenic rating 0/5. All ingredients (glycerin, hyaluronic acid, water) have zero comedogenic potential. Won't clog pores.

Sensitive Skin Friendly

Fragrance-free, alcohol-free, and preservative-free. Minimal ingredient list reduces irritation risk. Patch test recommended for very reactive skin.

Barley Allergy Warning

Contains barley-derived ingredients. Those with barley or gluten allergies should consult a dermatologist before use.

Skin Cancer Precaution

If you have a history of skin cancer, numerous moles, or excessive sun damage, consult your physician before using growth factor products.

03

Ingredient breakdown

INGREDIENTS

Barley EGF (SH-Oligopeptide-1)Proven

The star ingredient - a plant-based replica of human Epidermal Growth Factor produced through advanced biotechnology in barley plants. This signaling protein helps stimulate cell renewal and supports natural collagen production.

  • Nobel Prize: EGF discovery by Stanley Cohen earned the 1986 Nobel Prize in Physiology or Medicine
  • Clinical Study: 63% reduction in appearance of wrinkles after 3 months of use (BIOEFFECT in-house study)
  • Mechanism: Binds to EGF receptors to signal cell proliferation and wound healing processes
First plant-based EGF in skincare. Safer and more stable than bacteria-derived or animal-derived alternatives.

Sodium HyaluronateProven

The salt form of hyaluronic acid, known for its exceptional ability to hold up to 1,000 times its weight in water. Provides immediate and lasting hydration to plump and smooth skin.

  • Hydration: Attracts and retains moisture in the skin's upper layers
  • Plumping: Helps reduce the appearance of fine lines through hydration
  • Compatibility: Naturally found in skin, excellent tolerability

GlycerinProven

A powerful humectant that draws moisture into the skin and helps maintain the skin's lipid barrier. Provides long-lasting hydration without heaviness.

  • Study: More effective as a humectant than AHAs and hyaluronic acid alone (2016 research)
  • Barrier Support: Helps maintain skin's natural moisture barrier
  • Safety: Comedogenic rating 0, irritancy rating 0

Icelandic Water Base

Pure Icelandic water geologically filtered through layers of volcanic lava. Exceptionally soft and pure, free from hard minerals that can dry or irritate skin.

  • Purity: Low concentration of calcium and magnesium for optimal skin compatibility
  • Source: Naturally filtered through ancient lava fields in Iceland

Barley Seed ExtractPromising

Peptide-rich extract from barley that helps keep growth factors stable in the formula. Provides additional antioxidant and barrier-supporting benefits.

  • Stability: Helps maintain EGF potency throughout product shelf life
  • Antioxidant: Protects against UV radiation and environmental pollutants

7 ingredients

Glycerin, Water (Aqua), Sodium Hyaluronate, Tromethamine, Sodium Chloride, Barley (Hordeum Vulgare) Seed Extract, EGF (Barley SH-Oligopeptide-1)

FREE FROM: Parabens, Sulfates, Phthalates, Mineral Oil, Silicones, Synthetic Fragrance, Artificial Colors, Alcohol, PEGs, Formaldehyde, Hydroquinone, Retinoids, Fermented Ingredients, Fatty Acids, Esters, Essential Oils
04

Where it fits in your routine

ROUTINE
1
Cleanser
2
Toner/Essence
3
EGF Serum
4
Moisturizer
5
Sunscreen (AM)

Apply to clean skin after toner. Wait 3-5 minutes before layering moisturizer or makeup. For best results, apply on slightly damp skin. Works well with the BIOEFFECT EGF Essence as a prep step.

05

How to use

HOW TO USE
1

Cleanse & Prep

Start with freshly cleansed skin. For enhanced absorption, use a hydrating toner or the BIOEFFECT EGF Essence first.

2

Apply 2-4 Drops

Dispense 2-4 drops onto fingertips. A little goes a long way - using too much may cause stickiness.

3

Gently Press & Pat

Apply to face, neck, and décolleté using gentle upward motions. Pat gently to help absorption.

4

Wait Before Layering

Allow 3-5 minutes for full absorption before applying moisturizer, sunscreen, or makeup. Do not mix with other products immediately.

06

Who is it for?

WHO

Perfect for you if:

  • You want to target fine lines and wrinkles without using retinol
  • You're pregnant or breastfeeding and need a safe anti-aging option
  • You have sensitive skin and need a gentle, minimal formula
  • You prefer clean, science-backed skincare with proven ingredients
  • You have fungal acne and struggle to find safe anti-aging products
  • You want to maintain youthful skin and prevent signs of aging
  • You appreciate luxurious, high-quality skincare investments

Consider alternatives if:

  • You're on a tight budget (this is a premium-priced product)
  • You have a barley or gluten allergy
  • You prefer rich, creamy textures over lightweight serums
  • You have a history of skin cancer (consult doctor first)
  • You want instant results (this works gradually over weeks)
  • You dislike products with a slightly tacky feel during absorption
07

Skin type compatibility

SKIN TYPES
Dry Skin
Excellent

Hyaluronic acid and glycerin provide deep hydration. Works best when layered under a moisturizer to seal in benefits.

Oily Skin
Excellent

Lightweight, oil-free, water-based formula absorbs quickly without adding shine or greasiness to the skin.

Combination Skin
Excellent

Balances well across different face zones. Hydrates dry areas without overloading oily T-zone.

Sensitive Skin
Excellent

Fragrance-free, minimal ingredients make it highly tolerable. Patch test for 3 days recommended for very reactive skin.

Acne-Prone Skin
Excellent

Non-comedogenic (rating 0/5) and fungal acne safe. Oil-free formula won't trigger breakouts or clog pores.

Mature Skin
Excellent

Specifically designed to target signs of aging. EGF supports collagen production for improved firmness and density.

08

Results timeline

MONTH 3+
Week 1-2

Immediate Hydration Boost

Skin feels more hydrated and plump. Surface smoothing effect visible. Some users notice an immediate glow and improved skin texture.

85% noticed improved hydration
Week 3-4

Texture Improvement

Skin texture becomes smoother and more refined. Fine lines appear softer. Overall radiance and evenness improve noticeably.

72% saw texture improvement
Month 2-3

Visible Wrinkle Reduction

Significant reduction in the appearance of fine lines and wrinkles. Skin looks firmer and more elastic. Clinical studies show up to 63% wrinkle reduction.

63% reduction in wrinkle appearance
Month 3+

Long-Term Transformation

Continued improvement in skin density and firmness. Up to 68% improvement in elasticity. Best results with consistent twice-daily use.

68% improved skin elasticity
09

Ratings by platform

2K+ REVIEWS
Amazon
4.4
Rating
500+
Reviews
Main complaint: High price point for small bottle size. Some find texture sticky if too much is applied.
Sephora
4.3
Rating
150+
Reviews
Main complaint: Results take time to appear. Expensive compared to drugstore options.
Brand Website
4.8
Rating
2,000+
Reviews
Main complaint: Wish the bottle was larger. Some need to pair with extra moisturizer in winter.
Dermstore
4.6
Rating
300+
Reviews
Main complaint: Premium price makes repurchasing difficult for some budgets.
10

Pros & cons

BALANCED

Praised

  • Award-winning, clinically-proven formula with visible results
  • Minimal 7-ingredient formula reduces irritation risk
  • Safe for pregnancy, breastfeeding, and fungal acne
  • Fragrance-free and suitable for sensitive skin
  • Lightweight, fast-absorbing texture
  • Sustainable production using geothermal energy
  • Excellent alternative to retinol without irritation
  • Works well for all skin types including acne-prone

Criticized

  • Premium price point (~$175 for 15ml)
  • Can feel sticky if too much is applied
  • Results take 4-8 weeks to become visible
  • Small bottle size for the price
  • Not hydrating enough alone for very dry skin
  • Contains barley (not suitable for gluten allergies)
  • Needs 3-5 minute wait time before layering
11

Budget-friendly alternatives (dupes)

DUPES
85% Match
GF 15% Solution
$15.50
Budget Pick

Features 3 plant-based growth factors (EGF, IGF, TGF) at an unbeatable price. Lighter texture, similar goals. May not have the same bioavailability as BIOEFFECT's barley-derived EGF.

70% Match
15% Vitamin C And EGF Serum
$16.99
Budget Pick

Combines plant-derived EGF with Vitamin C for brightening. Different formula focus but targets similar aging concerns at a fraction of the price.

65% Match
Advanced Snail 96 Mucin Power Essence
$25.00
Budget Pick

Different active (snail mucin) but similar skin-regenerating and hydrating benefits. More hydrating texture. Budget-friendly K-beauty option for repair and renewal.

55% Match
Glo Skin Beauty Bio-Renew EGF Drops
$125.00
Similar Tier

Vegan synthetic EGF in a booster format. Can be mixed into other products. Similar price tier with slightly different delivery system and formula.

12

Comparison with competitors

SIDE-BY-SIDE
TNS® Advanced+ Serum

SkinMedica TNS Advanced+ Serum

Key Ingredient Human Fibroblast Media
Size 28ml / 1 fl oz
Ingredient Count 40+ ingredients
Fragrance-Free No
Clinical Studies Yes - Extensive
Cost Per ml $10.54/ml
GF 15% Solution
Key Ingredient Plant-Based EGF/IGF/TGF
Size 30ml / 1 fl oz
Ingredient Count 10 ingredients
Fragrance-Free Yes
Clinical Studies Limited
Cost Per ml $0.52/ml
Advanced Night Repair Eye Supercharged Complex
Key Ingredient Bifidus Ferment Lysate
Size 50ml / 1.7 fl oz
Ingredient Count 50+ ingredients
Fragrance-Free No - Contains Fragrance
Clinical Studies Yes - Extensive
Cost Per ml $2.10/ml
13

Storage & shelf life

12 MONTHS
Period After Opening (PAO)

12 months after opening. Use consistently twice daily to finish within recommended timeframe.

Storage

Store at room temperature or below. Keep out of direct sunlight. Do not expose to extreme heat.

Packaging

Airless pump dropper bottle. Preserves formula integrity and prevents contamination.

Travel Friendly

Yes, under 100ml/3.4oz TSA limit. Compact size perfect for travel skincare routines.

13

Frequently asked questions

FAQ

Yes, BIOEFFECT EGF Serum is considered safe during pregnancy and breastfeeding. The formula contains no retinoids, salicylic acid, hydroquinone, or other pregnancy-restricted ingredients. EGF (Epidermal Growth Factor) is naturally present in the body and is considered a safe alternative to retinol during pregnancy. However, as with any skincare product, it's always recommended to consult with your healthcare provider before introducing new products during pregnancy or nursing.

Yes, BIOEFFECT EGF Serum is fungal acne safe with zero malassezia triggers. The formula contains no ferments, problematic fatty acids, esters, or polysorbates that can feed malassezia yeast. Its minimal 7-ingredient formula consisting of glycerin, water, sodium hyaluronate, tromethamine, sodium chloride, barley seed extract, and EGF is completely safe for those dealing with fungal acne.

Yes, EGF can be used alongside retinol, Vitamin C, and AHA/BHA acids. However, for best results, consider using them at different times of day: EGF in the morning, and stronger actives like retinol or acids in the evening. Some dermatologists suggest that using EGF after retinol can help soothe skin and enhance repair. Always wait for the serum to fully absorb (3-5 minutes) before layering other products.

BIOEFFECT EGF Serum is suitable for all skin types including dry, oily, combination, sensitive, acne-prone, and mature skin. Its lightweight, oil-free, water-based formula makes it particularly excellent for oily and combination skin, while the hyaluronic acid and glycerin provide adequate hydration for dry skin when layered under a moisturizer. The fragrance-free, minimal formula is ideal for sensitive skin types.

Most users notice improved hydration and a subtle glow within the first 1-2 weeks. Visible improvements in skin texture typically appear around weeks 3-4. Significant reduction in fine lines and wrinkles (up to 63%) is generally observed after 2-3 months of consistent twice-daily use. For best results, use morning and night for at least 3 months. Results are cumulative and improve with continued use.

Apply BIOEFFECT EGF Serum after cleansing and toning, before moisturizer. For optimal results: 1) Cleanse, 2) Apply toner or essence (optional - the BIOEFFECT EGF Essence works perfectly as prep), 3) Apply 2-4 drops of EGF Serum, 4) Wait 3-5 minutes for absorption, 5) Apply moisturizer, 6) Sunscreen (morning only). The serum can be used both morning and evening.

No, BIOEFFECT EGF Serum has a comedogenic rating of 0/5 and will not clog pores. All ingredients in the formula (glycerin, water, sodium hyaluronate, tromethamine, sodium chloride, barley seed extract, and EGF) have zero to negligible comedogenic potential. The oil-free, water-based formula is specifically designed to be non-pore-clogging and is safe for acne-prone skin.

BIOEFFECT EGF Serum should be used within 12 months after opening (PAO: 12M). The airless pump packaging helps preserve the formula's integrity and prevents contamination. For best results, use consistently twice daily - at this rate, a 15ml bottle typically lasts 2-3 months. Store at room temperature, away from direct sunlight and extreme temperatures.

— Skincarisma verdict
4.5 / 5 ★★★★★

Verdict: BIOEFFECT EGF Serum is a premium, science-backed anti-aging serum that delivers on its promises for those willing to invest. The Nobel Prize-winning research behind EGF, combined with a minimalist 7-ingredient formula, makes it ideal for sensitive skin types and those seeking a retinol alternative. While the price point is high, the clinically-proven results (up to 63% wrinkle reduction) and excellent safety profile for pregnancy, breastfeeding, and fungal acne sufferers justify the investment for many users. Best suited for those who prioritize clean formulations, gentle yet effective anti-aging, and sustainable biotech skincare.

Product Overview

question
lightbulb What are Quick Product Notes?

Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.

muscle Pro Tip Alert!

Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.

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Quick Product Notes

Click on icons for more information
question
lightbulb What are Notable Effects & Ingredients?

Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging «promises» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.

We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.

muscle Pro Tip Alert!

Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.

Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you

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Notable Effects & Ingredients

brightening Brightening from 1 ingredient(s):
Glycerin
wound Promotes Wound Healing from 2 ingredient(s):
Glycerin Sodium Hyaluronate
question
lightbulb What are Ingredients Related to Skin Type?

Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.

We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.

muscle Pro Tip Alert!

A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.

One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!

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Ingredients Related to Skin Types

Click on icons for more information
dry-skin Dry Skin
2
oily-skin Oily/Acne-Prone Skin
sensitive-skin Sensitive Skin
question
lightbulb What is the Ingredient Safety Breakdown?

Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.

muscle Pro Tip Alert!

EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.

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Ingredient Safety Breakdown

EWG Health Ratings
Low risk
Medium risk
High risk
Unknown risk
71% 28%

Product ingredient list

Showing first 5 of 7 ingredients
EWG CIR Ingredient Name & Cosmetic Functions Notes
2 A
Glycerin
Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant, Skin Conditioning
brightening Brightening
Promotes Wound Healing
Hydrating
1 Unknown
Water
Solvent, Skin Conditioning
1 A
Sodium Hyaluronate
Skin Conditioning, Humectant
Promotes Wound Healing
Hydrating
0 Unknown
Tromethamine
1 Unknown
Sodium Chloride
Masking, Viscosity Controlling, Bulking Agent
VIEW ALL INGREDIENTS