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Gentle Clear Triple Action Acne Serum

Gentle Clear Triple Action Acne Serum

Product Description

Product overview

Made in USA CLINICAL

A gentle yet effective milky-gel serum with 0.5% salicylic acid that improves the appearance of breakouts in just 3 days. Formulated with PHA, succinic acid, niacinamide, and zinc for sensitive, acne-prone skin with 24-hour hydration.

Dermatologist Recommended Fragrance-Free Hypoallergenic Non-Comedogenic Oil-Free HSA/FSA Eligible Clinically Tested
Pregnancy
Caution
Fungal Acne
No
Comedogenic
1/5
Size
1 fl oz (30mL)
Price
~$14.97
Active
0.5% Salicylic Acid
pH Level
~3.5-4.0
Rating
4.3/5
Real reviews · YouTube Shorts
Why it's different

Triple-Action Formula

Treats current acne, prevents future breakouts, and reduces the appearance of post-acne marks with one serum.

01

Texture & feel

SENSORY
Consistency
Milky-Gel
Scent
Fragrance-Free
Absorption
30-60 seconds
Finish
Natural/Matte

Triple-Action Formula

Treats current acne, prevents future breakouts, and reduces the appearance of post-acne marks with one serum.

24-Hour Hydration

Unlike harsh acne treatments, this formula provides all-day moisture while treating breakouts without over-drying.

Sensitive Skin Friendly

Hypoallergenic, fragrance-free, and oil-free formula designed specifically for sensitive, acne-prone skin.

Multi-Acid Exfoliation

Combines BHA (salicylic acid) with PHA (gluconolactone) and succinic acid for gentle yet effective exfoliation.

02

Safety & compatibility

SAFE
Pregnancy & Breastfeeding

Contains 0.5% salicylic acid. While under the 2% threshold considered safe by ACOG, consult your healthcare provider before use during pregnancy or breastfeeding.

Fungal Acne (Malassezia)

Not fungal acne safe. Contains Coco-Caprylate/Caprate, an ester that can feed malassezia yeast and worsen fungal acne.

Sensitive Skin

Hypoallergenic, fragrance-free, and dermatologist-tested. Defends against 5 signs of skin sensitivity.

Non-Comedogenic

Won't clog pores. Low comedogenic rating of 1/5 makes it suitable for acne-prone skin.

03

Ingredient breakdown

INGREDIENTS

Salicylic Acid 0.5%Proven

A beta-hydroxy acid (BHA) that penetrates pores to dissolve oil, dead skin cells, and debris. Effective at treating and preventing acne breakouts.

  • Mechanism: Oil-soluble acid that exfoliates inside pores
  • Benefits: Unclogs pores, reduces blackheads and whiteheads, anti-inflammatory
  • Studies: Proven effective for mild-to-moderate acne
Lower concentration (0.5%) is gentler than typical 2% formulas but may be less potent for severe acne.

Gluconolactone (PHA) ~2-3%Proven

A polyhydroxy acid that gently exfoliates while providing hydration. Larger molecular size makes it gentler than AHAs.

  • Mechanism: Gentle exfoliation with humectant properties
  • Benefits: Brightens skin, smooths texture, attracts moisture
  • Studies: Well-tolerated even by sensitive and rosacea-prone skin
Ideal for sensitive skin as it exfoliates without irritation.

Niacinamide (Vitamin B3) ~1-2%Proven

A multi-tasking ingredient that strengthens skin barrier, regulates oil production, and reduces inflammation.

  • Mechanism: Increases ceramide synthesis, reduces sebum
  • Benefits: Minimizes pores, fades dark spots, calms redness
  • Studies: Effective at 2-5% for acne and hyperpigmentation

Succinic Acid ~1%Promising

An organic acid with antimicrobial and anti-inflammatory properties, particularly effective against acne-causing bacteria.

  • Mechanism: Inhibits P. acnes bacteria growth
  • Benefits: Reduces inflammation, soothes breakouts
  • Studies: Emerging research shows promise for acne treatment

Zinc Gluconate ~0.5%Proven

A zinc salt with antibacterial and sebum-regulating properties, proven effective for inflammatory acne.

  • Mechanism: Inhibits 5α-reductase, reduces oil production
  • Benefits: Antibacterial, wound healing, oil control
  • Studies: Oral zinc shown 31.2% success rate for acne

17 ingredients

Salicylic Acid (0.5%), Water, Glycerin, Coco-Caprylate/Caprate, Gluconolactone, Propanediol, Sodium Hydroxide, Succinic Acid, Panthenol, Niacinamide, Lysolecithin, Sclerotium Gum, Zinc Gluconate, Pullulan, Xanthan Gum, Pantolactone, Citric Acid, Silica

FREE FROM: Fragrance, Parabens, Sulfates, Alcohol (Drying), Silicones, Phthalates, Mineral Oil, Artificial Dyes
04

Where it fits in your routine

ROUTINE
1
Cleanser
2
Toner
3
This Serum
4
Moisturizer
5
Sunscreen (AM)

Use morning and/or evening. Start with once daily and increase to 2-3 times daily as tolerated. Always apply sunscreen in the morning as salicylic acid increases sun sensitivity.

05

How to use

HOW TO USE
1

Cleanse Thoroughly

Start with clean skin. Use a gentle, non-stripping cleanser and pat dry.

2

Apply Thin Layer

Squeeze a small amount onto fingertips and apply a thin layer to entire face, avoiding eye area.

3

Allow Absorption

Wait 1-2 minutes for complete absorption before applying next product.

4

Follow with Moisturizer

Apply your regular moisturizer. In the morning, always finish with SPF 30+.

06

Who is it for?

WHO

Perfect for you if:

  • You have sensitive, acne-prone skin
  • You experience mild to moderate breakouts
  • Harsh acne treatments irritate your skin
  • You want to prevent and treat acne simultaneously
  • You prefer fragrance-free, gentle formulas
  • You want to fade post-acne marks

Consider alternatives if:

  • You have severe cystic acne (need stronger treatment)
  • You have fungal acne/malassezia folliculitis
  • You're pregnant (consult doctor first)
  • You need a higher % salicylic acid (2%)
  • You have a salicylate allergy
07

Skin type compatibility

SKIN TYPES
Oily Skin
Excellent

Zinc and salicylic acid help control excess oil while keeping skin hydrated without greasiness.

Combination Skin
Excellent

Balances oily T-zone while providing hydration to drier areas. Well-suited for mixed skin.

Sensitive Skin
Good

Gentle formula with low 0.5% salicylic acid. Some may experience initial dryness—start slowly.

Dry Skin
Moderate

May cause dryness despite hydrating ingredients. Layer with a heavier moisturizer.

Acne-Prone Skin
Excellent

Non-comedogenic with proven acne-fighting ingredients. Great for mild-moderate acne.

08

Results timeline

4-8 WEEKS
3 Days

Visible Improvement in Active Breakouts

Clinically proven to improve the appearance of breakouts within the first 3 days. Reduced redness and inflammation.

93% trust it to clear breakouts
1 Week

Clearer Skin & Refined Texture

Clinically shown to improve the look of blemishes. Pores appear smaller, skin feels smoother.

90% felt more confident
2-4 Weeks

Reduced Breakout Frequency

With consistent use, experience fewer new breakouts. Oil production becomes more balanced.

Most users see significant improvement
4-8 Weeks

Fading Post-Acne Marks

Continued use helps fade post-acne discoloration. Skin tone appears more even and radiant.

Visible improvement in skin tone
09

Ratings by platform

860+ REVIEWS
Cetaphil.com
4.3
Rating
210+
Reviews
Main complaint: Can be drying for very sensitive skin if used too frequently
Amazon
4.2
Rating
500+
Reviews
Main complaint: Small bottle size for the price (1 oz)
iHerb
4.0
Rating
50+
Reviews
Main complaint: Takes time to show results; pricey for travel size
Influenster
4.4
Rating
100+
Reviews
Main complaint: Packaging looks like a cleanser, can be confusing
10

Pros & cons

BALANCED

Praised

  • Gentle enough for sensitive skin
  • Works fast—visible results in 3 days
  • Non-irritating, no burning or stinging
  • Fragrance-free formula
  • Hydrating despite being an acne treatment
  • Doesn't bleach clothes or bedding
  • Silky texture, absorbs quickly
  • Tube packaging is hygienic and travel-friendly

Criticized

  • Small bottle size (1 oz) for the price
  • May be too gentle for severe acne
  • Can cause dryness with frequent use
  • Lower salicylic acid % than some competitors
  • Not fungal acne safe
  • Tube looks like a cleanser—confusing packaging
  • Takes consistent use to see full results
11

Budget-friendly alternatives (dupes)

DUPES
85% Match
Salicylic Acid 2% Solution
$6.80
Budget Pick

Higher 2% salicylic acid concentration. Simpler formula without PHA or niacinamide. More potent but potentially more drying. Fungal acne safe.

75% Match
Acne Control Gel
$16.99
Similar Price

Contains 2% salicylic acid plus ceramides and niacinamide. Gel texture vs milky-gel. Added ceramides for barrier support. Larger 1.35 oz size.

70% Match
Stubborn Acne AM Face Treatment
$9.99
Budget Pick

Contains 2.5% benzoyl peroxide instead of salicylic acid. Stronger antibacterial action but may bleach fabrics. Different mechanism of action.

12

Comparison with competitors

SIDE-BY-SIDE
Skin Perfecting 2% BHA Liquid Exfoliant
Active Ingredient 2% Salicylic Acid
Size 4 fl oz (118mL)
Price per oz $8.75/oz
Fragrance Fragrance-Free
Best For All Skin Types, Pores
EFFACLAR K+
Active Ingredient Glycolic + Salicylic Acid
Size 1 fl oz (30mL)
Price per oz $39.99/oz
Fragrance Contains Fragrance
Best For Post-Acne Marks
Salicylic Acid 2% Solution
Active Ingredient 2% Salicylic Acid
Size 1 fl oz (30mL)
Price per oz $6.80/oz
Fragrance Fragrance-Free
Best For Budget-Conscious, Oily
13

Storage & shelf life

12 MONTHS
Period After Opening (PAO)

12 months after opening

Storage

Store at room temperature in a cool, dry place. Keep away from direct sunlight and heat.

Packaging

Squeeze tube with flip-top cap. Hygienic design prevents contamination.

Travel Friendly

Yes, 1 oz (30mL) is TSA-approved for carry-on luggage.

13

Frequently asked questions

FAQ

Use with caution. This product contains 0.5% salicylic acid, which is below the 2% threshold the American College of Obstetricians and Gynecologists considers safe during pregnancy. However, salicylic acid can be absorbed through the skin, so it's best to consult your healthcare provider before use during pregnancy or breastfeeding. If you choose to use it while breastfeeding, avoid applying to chest areas.

No, this serum is NOT fungal acne safe. It contains Coco-Caprylate/Caprate, an ester derived from coconut that can feed malassezia yeast and potentially worsen fungal acne. If you have fungal acne or pityrosporum folliculitis, consider alternatives like The Ordinary Salicylic Acid 2% Solution, which has a simpler, fungal acne-safe formula.

Yes, but with caution. This serum already contains multiple acids (salicylic acid, gluconolactone, succinic acid), so adding more actives may cause irritation. If using retinol, apply them on alternate nights. Vitamin C can be used in the morning while this serum is used at night. Avoid layering with other strong AHAs/BHAs to prevent over-exfoliation. Start slowly and monitor your skin's response.

This serum is best for sensitive, oily, combination, and acne-prone skin types experiencing mild to moderate breakouts. The gentle 0.5% salicylic acid concentration with hydrating ingredients makes it ideal for those who find stronger acne treatments too harsh. Those with dry skin may need to layer with a heavier moisturizer. It's not recommended for severe cystic acne or fungal acne.

Clinically proven to improve the appearance of breakouts in just 3 days. Most users notice reduced redness and smaller pimples within the first week. Significant improvement in overall skin clarity typically occurs within 2-4 weeks of consistent use. For post-acne marks, expect to see visible fading after 4-8 weeks. Results vary based on severity of acne and consistency of use.

Apply after cleansing and toning (if using a toner), but before moisturizer and sunscreen. The order is: Cleanser → Toner (optional) → This Serum → Moisturizer → Sunscreen (AM only). Wait 1-2 minutes after applying the serum before layering other products. Always use sunscreen during the day as salicylic acid increases sun sensitivity.

No, this serum is labeled non-comedogenic and has a low comedogenic rating of 1/5. It's oil-free and specifically designed not to clog pores. The salicylic acid actually helps unclog existing pores by dissolving the oil and dead skin cells trapped inside. However, everyone's skin is different—if you notice increased breakouts after starting use, discontinue and consult a dermatologist.

This product has a Period After Opening (PAO) of 12 months. Once opened, use within one year for optimal effectiveness and safety. The squeeze tube design helps minimize air exposure and contamination. Store in a cool, dry place away from direct sunlight. If the product changes color, texture, or smell, discard it regardless of the time since opening.

— Skincarisma verdict
4.3 / 5 ★★★★☆

Verdict: Cetaphil Gentle Clear Triple-Action Acne Serum is an excellent choice for those with sensitive, acne-prone skin who need a gentle yet effective treatment. The low 0.5% salicylic acid combined with PHA, niacinamide, and zinc provides multi-action benefits without the harshness of typical acne products. Clinically proven to show results in 3 days, it's dermatologist-recommended and HSA/FSA eligible. The main drawbacks are its small size for the price and that it's not suitable for fungal acne or severe cystic acne. For those seeking a beginner-friendly, non-irritating acne serum from a trusted drugstore brand, this is a solid choice.

Product Overview

question
lightbulb What are Quick Product Notes?

Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.

muscle Pro Tip Alert!

Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.

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Quick Product Notes

Click on icons for more information
question
lightbulb What are Notable Effects & Ingredients?

Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging «promises» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.

We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.

muscle Pro Tip Alert!

Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.

Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you

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Notable Effects & Ingredients

anti-aging Anti-Aging from 3 ingredient(s):
Gluconolactone Niacinamide Citric Acid
brightening Brightening from 4 ingredient(s):
Salicylic Acid Glycerin Niacinamide Citric Acid
wound Promotes Wound Healing from 4 ingredient(s):
Glycerin Panthenol Niacinamide Citric Acid
ache Ache-fighting from 2 ingredient(s):
Salicylic Acid Niacinamide
question
lightbulb What are Ingredients Related to Skin Type?

Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.

We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.

muscle Pro Tip Alert!

A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.

One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!

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Ingredients Related to Skin Types

Click on icons for more information
dry-skin Dry Skin
2
oily-skin Oily/Acne-Prone Skin
2 1
sensitive-skin Sensitive Skin
question
lightbulb What is the Ingredient Safety Breakdown?

Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.

muscle Pro Tip Alert!

EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.

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Ingredient Safety Breakdown

EWG Health Ratings
Low risk
Medium risk
High risk
Unknown risk
72% 16% 11%

Product ingredient list

Showing first 5 of 18 ingredients
EWG CIR Ingredient Name & Cosmetic Functions Notes
4 B
Salicylic Acid
Skin Conditioning, Masking, Fragrance, Hair Conditioning, Antidandruff Agent, Antiacne Agent, Denaturant, Preservative, Exfoliant, Keratolytic, Corn/Callus/Wart Remover
brightening Brightening
ache Ache-fighting
Pores
1 Unknown
Water
Solvent, Skin Conditioning
2 A
Glycerin
Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant, Skin Conditioning
brightening Brightening
Promotes Wound Healing
Hydrating
1 B
Coco-Caprylate/Caprate
Emollient, Skin Conditioning
1 Unknown
Gluconolactone
Solvent, Fragrance, Humectant, Skin Conditioning
anti-aging Anti-Aging
VIEW ALL INGREDIENTS