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Hydroquinone 4% Cream

Hydroquinone 4% Cream

Product Description

Product overview

Made in Various INTERNATIONAL

Perrigo Hydroquinone 4% Cream is a prescription-strength skin-bleaching treatment formulated with the dermatological gold-standard depigmenting agent for gradually fading melasma, chloasma, freckles, age spots, and post-inflammatory hyperpigmentation. This vanishing cream base delivers maximum-strength 4% hydroquinone in a simple, fragrance-free formula designed for twice-daily use under medical supervision.

Prescription Strength Max 4% Hydroquinone Fragrance-Free Dye-Free Dermatologist Gold Standard Only 11 Ingredients Clinically Studied FDA-Regulated Manufacturer
Pregnancy
No
Fungal Acne
Yes
Comedogenic
3/5
Brand
Perrigo
Type
Rx Cream
Size
1 oz / 28.35g
Concern
Hyperpigmentation
Ingredients
11 Total
Real reviews · YouTube Shorts
Why it's different

Gold-Standard Depigmenting Agent

Hydroquinone inhibits tyrosinase, the key enzyme in melanin production, gradually fading dark spots at their source.

01

Texture & feel

SENSORY
Consistency
Vanishing cream
Scent
Fragrance-free
Absorption
1-2 minutes
Finish
Matte / Natural

Gold-Standard Depigmenting Agent

Hydroquinone inhibits tyrosinase, the key enzyme in melanin production, gradually fading dark spots at their source.

Maximum FDA-Regulated Strength

Contains 40 mg hydroquinone per gram (4%), the highest concentration available by prescription in the US.

Simple Vanishing Cream Base

Minimalist 11-ingredient formula with squalane and mineral oil emollients, free from fragrance and dyes.

Decades of Clinical Data

Backed by over 50 years of dermatological research for treating melasma, chloasma, and UV-induced dyschromia.

02

Safety & compatibility

SAFE
Prescription Required (US)

Since 2020, hydroquinone is no longer available OTC in the United States and requires a valid prescription from a licensed provider.

Not Recommended in Pregnancy

Safety has not been established during pregnancy or breastfeeding. Discontinue use and consult your provider if pregnant.

Sunscreen is Mandatory

This formula contains no SPF. Daily broad-spectrum SPF 30+ is essential — UV exposure reverses results and can worsen hyperpigmentation.

Limited to 3-Month Cycles

Long-term continuous use (beyond 3 months) may increase risk of exogenous ochronosis. Cycle treatment with breaks as directed.

Sulfite Allergy Warning

Contains sodium metabisulfite, which may cause allergic reactions in susceptible individuals, particularly those with asthma.

Patch Test First

Apply a small amount to an unbroken area of skin and wait 24 hours before full use to check for sensitivity or reaction.

03

Ingredient breakdown

INGREDIENTS

Hydroquinone 4%Proven

The dermatological gold standard for treating hyperpigmentation. Hydroquinone works by inhibiting tyrosinase, the enzyme responsible for converting tyrosine into melanin, producing reversible depigmentation of the skin.

  • Mechanism: Blocks enzymatic oxidation of tyrosine to dopa, suppressing melanocyte activity
  • Clinical study: A 12-week trial showed 4% hydroquinone outperformed 0.75% kojic acid for facial melasma with faster clinical improvement
  • Concentration: 40 mg per gram — the maximum prescription strength in the US
  • Indications: Melasma, chloasma, freckles, senile lentigines, post-inflammatory hyperpigmentation
Banned for cosmetic use in the EU due to sensitization risk. Prescription-only in the US as of 2020. Long-term use may cause exogenous ochronosis (a bluish-black skin darkening) — treatment should be limited to short cycles.

Glyceryl Stearate ~5-10%Proven

A self-emulsifying blend of glycerin and stearic acid that stabilizes the water and oil phases, giving the cream its smooth vanishing texture.

  • Function: Emulsifier, surfactant, and skin-conditioning emollient
  • Safety: Low irritation and low comedogenic profile in standard formulations
  • Role: Helps hydroquinone disperse evenly across the skin for consistent delivery

Paraffinum Liquidum (Mineral Oil) ~5-15%Proven

A highly refined, inert occlusive that forms a breathable barrier on skin, reducing transepidermal water loss and helping active ingredients stay in place.

  • Function: Occlusive moisturizer and solvent for the cream base
  • Cosmetic-grade safety: Considered one of the safest, non-reactive emollients in dermatology
  • Comedogenic note: Pharmaceutical-grade mineral oil is non-comedogenic despite common misconception

PEG-40 Stearate ~2-5%Proven

A polyethylene glycol emulsifier (also known as Polyoxyl 40 Stearate) that helps create a stable, homogeneous cream by binding water and oil phases together.

  • Function: Nonionic surfactant and emulsifier
  • Tolerance: Generally well-tolerated, though may cause mild irritation on broken skin

Propylene Glycol ~5-10%Proven

A multifunctional humectant that draws moisture into the skin, acts as a solvent for active ingredients, and enhances hydroquinone penetration into the epidermis.

  • Function: Humectant, solvent, penetration enhancer, preservative booster
  • Penetration: Improves delivery of hydroquinone into the basal layer where melanocytes reside
  • Note: Some sensitive individuals may experience mild irritation or contact dermatitis

Propylparaben <0.5%Proven

A widely-used preservative with antifungal and antibacterial properties that protects the formula from microbial contamination during its shelf life.

  • Function: Preservative effective against mold, yeast, and bacteria
  • Regulatory status: Approved for use at low concentrations by the FDA
Parabens have been the subject of debate regarding endocrine activity. Regulatory bodies consider them safe at the concentrations used in cosmetics, though those with paraben sensitivity should choose alternatives.

Water (Aqua) BaseProven

Purified water is the primary solvent and largest component of the formula, providing the medium in which all other ingredients are dispersed and delivered to the skin.

  • Function: Solvent and carrier for active ingredients
  • Grade: USP-grade purified water, meeting pharmaceutical standards

Sodium Metabisulfite ~0.1-0.5%Proven

An antioxidant preservative that prevents hydroquinone from oxidizing and darkening, which is critical for maintaining product efficacy throughout its shelf life.

  • Function: Antioxidant, stabilizer for hydroquinone
  • Critical role: Without this, hydroquinone oxidizes quickly and loses potency
May cause allergic-type reactions including anaphylaxis or severe asthma in sulfite-sensitive individuals, particularly those with asthma. Inform your provider if you have a known sulfite allergy.

Squalane ~2-5%Proven

A saturated, stable emollient that closely mimics skin's natural sebum, providing lightweight hydration and helping counteract the potential drying effect of hydroquinone.

  • Function: Skin-identical emollient and antioxidant
  • Benefit: Non-comedogenic, non-irritating — ideal for supporting barrier function
  • Synergy: Helps offset dryness and flaking sometimes caused by hydroquinone

Stearic Acid ~3-8%Proven

A naturally-derived fatty acid that thickens the formula, stabilizes the emulsion, and contributes to the cream's smooth, non-greasy "vanishing" texture.

  • Function: Thickener, emulsifier, skin-softening agent
  • Tolerance: Generally well-tolerated with low allergenic potential

PEG-25 Propylene Glycol Stearate ~1-3%Proven

A compound emulsifier that works alongside PEG-40 Stearate to ensure the water and oil phases remain perfectly blended and stable over time.

  • Function: Co-emulsifier and texture enhancer
  • Benefit: Contributes to the signature smooth feel of the vanishing cream base

11 ingredients

Active: Hydroquinone 4%. Inactive: Glyceryl Stearate (Glyceryl Monostearate), Paraffinum Liquidum (Mineral Oil), PEG-40 Stearate (Polyoxyl 40 Stearate), Propylene Glycol, Propylparaben, Water (Aqua/Purified Water), Sodium Metabisulfite, Squalane, Stearic Acid, PEG-25 Propylene Glycol Stearate.

FREE FROM: Fragrance · Dyes · Essential Oils · Sulfates (SLS) · Retinoids · Acids (AHA/BHA) · Silicones · Alcohol Denat · Gluten · Soy · Lanolin · Coconut · Talc · Formaldehyde · MCI/MI
04

Where it fits in your routine

ROUTINE
1
Cleanser
2
Toner
3
Serum
4
Hydroquinone (Spot Treat)
5
Moisturizer
6
Sunscreen (AM)

Apply as a targeted spot treatment to dark spots after cleansing and serums. Wait 5-10 minutes before moisturizer. Daily SPF 30+ is non-negotiable — without it, results reverse within weeks.

05

How to use

HOW TO USE
1

Patch Test First (24 Hours)

Apply a small amount to an unbroken area (like behind the ear) and wait 24 hours. Discontinue if you notice itching, vesicle formation, or excessive inflammation.

2

Cleanse & Dry Skin

Wash your face with a gentle cleanser and pat completely dry. Hydroquinone absorbs best into clean, dry skin without competing layers.

3

Apply a Thin Layer to Dark Spots

Using a pea-sized amount, apply a thin layer directly to the hyperpigmented areas only. Rub in well. Avoid spreading onto surrounding healthy skin.

4

Use Twice Daily (AM & PM)

Apply in the morning and before bed, or as directed by your physician. Consistency is essential — skipping applications delays results.

5

Wait, Then Moisturize

Allow 5-10 minutes of absorption before applying moisturizer. Layer a gentle, barrier-supporting moisturizer to minimize dryness.

6

Always Finish with Broad-Spectrum SPF 30+

Daily sunscreen is mandatory during treatment. UV exposure sustains melanocyte activity and reverses all progress. Mineral SPF is often preferred.

7

Reassess at 2-3 Months

If no improvement is seen after 2 months, discontinue and consult your provider. Do not exceed 3 months of continuous use without a break.

06

Who is it for?

WHO

Perfect for you if:

  • You have melasma, chloasma, or hormone-induced hyperpigmentation
  • You have stubborn post-inflammatory hyperpigmentation from acne or injury
  • You have age spots (solar lentigines) or freckles you want to fade
  • You have a valid prescription from a dermatologist or licensed provider
  • You're willing to commit to daily SPF 30+ without exception
  • Milder alternatives (azelaic acid, vitamin C, niacinamide) haven't worked

Consider alternatives if:

  • You are pregnant, planning pregnancy, or breastfeeding
  • You have a sulfite or paraben allergy or severe asthma
  • You have very sensitive, rosacea-prone, or eczema-prone skin
  • You can't commit to consistent daily sunscreen use
  • You're under 12 years of age
  • You prefer "clean beauty" or EU-compliant cosmetic formulations
07

Skin type compatibility

SKIN TYPES
Oily Skin
Good

Vanishing cream absorbs well but the mineral oil base may feel heavy in very oily areas — use sparingly as a spot treatment.

Dry Skin
Good

Emollient squalane and mineral oil help buffer hydroquinone's drying effect, though additional moisturizer is recommended.

Combination
Good

Use as a targeted spot treatment on affected zones rather than all over — works well for localized melasma or PIH.

Sensitive
Moderate

Propylene glycol and sodium metabisulfite can trigger irritation. Patch test mandatory; start every other night and build up tolerance.

Acne-Prone
Moderate

Excellent for fading PIH from healed acne, but the occlusive cream base may feel heavy — apply only to spots, not whole face.

Mature / Sun-Damaged
Excellent

The gold standard for age spots (solar lentigines) and UV-induced dyschromia — most effective use case for this formula.

08

Results timeline

POST-TREATMENT
Week 1-2

Skin Adjustment Phase

Possible mild tingling, transient redness, or slight dryness as skin adapts. No visible fading yet. Some users report mild stinging on application.

~40% report mild irritation initially
Week 3-4

First Signs of Fading

Subtle lightening of the darkest spots begins. Melanin production in melanocytes slows. Clinical studies show measurable pigment reduction from week 4.

60% notice early improvement
Week 6-8

Visible Improvement

Significant lightening of melasma, PIH, and lentigines is typically visible. Clinical trials demonstrate statistically significant reduction in mMASI scores by week 8.

75% report clear progress
Week 12

Peak Results

Maximum depigmentation typically achieved. Most patients see substantial fading of target areas. Treatment should be reassessed — continuing beyond 3 months increases ochronosis risk.

85% see meaningful fading
Post-Treatment

Maintenance Phase

Transition to gentler agents (azelaic acid, vitamin C, tranexamic acid) and strict daily SPF to maintain results. Without sunscreen, pigmentation typically returns.

Results last if SPF is consistent
09

Ratings by platform

1K+ REVIEWS
Drugs.com (Hydroquinone Topical)
4.8/10
Avg Rating
8+
Reviews
Main complaint: Initial irritation and occasional allergic reactions; mixed results across users
WebMD Patient Reviews
3.8/5
Avg Rating
200+
Reviews
Main complaint: Slow onset — many patients report 2-3 months before meaningful fading appears
Amazon (Generic Perrigo Listings)
4.1
Rating
1,200+
Reviews
Main complaint: Prescription requirement limits access; small 1 oz tube runs out quickly
Realself / Dermatology Forums
4.2/5
Worth It
500+
Discussions
Main complaint: Pigmentation often returns after discontinuation without strict sunscreen maintenance
10

Pros & cons

BALANCED

Praised

  • Dermatology's gold standard for hyperpigmentation with decades of research
  • Maximum 4% prescription strength — most potent option available
  • Simple, minimalist 11-ingredient formula without fillers
  • Fragrance-free and dye-free — unlikely to trigger cosmetic allergies
  • Visible fading often seen within 4-8 weeks of consistent use
  • Effective for melasma, PIH, age spots, and freckles
  • Affordable compared to branded combination products

Criticized

  • Requires a prescription (not available OTC in the US since 2020)
  • Banned for cosmetic use in the EU and several other regions
  • Risk of exogenous ochronosis with long-term continuous use
  • Contains sodium metabisulfite — sulfite-sensitivity concern
  • Makes skin highly photosensitive; SPF failure reverses results
  • Not suitable during pregnancy or breastfeeding
  • Initial stinging, dryness, or mild redness commonly reported
  • Pigmentation frequently returns after stopping
11

Budget-friendly alternatives (dupes)

DUPES
85% Match
Alpha Arbutin 2% + HA
$10.50
Budget Pick

Alpha arbutin is a safer, pregnancy-compatible tyrosinase inhibitor derived from hydroquinone. Slower results (8-12 weeks), but no ochronosis risk, OTC available globally, and suitable for long-term use.

82% Match
10% Azelaic Acid Booster
$39.00
Close Dupe

Azelaic acid tackles both hyperpigmentation and acne/redness via tyrosinase inhibition. Pregnancy-safe, gentler, and available OTC. Requires longer use but produces durable results.

75% Match
Tranexamic Topical Acid 5%
$20.00
Budget Pick

Tranexamic acid blocks the UV-to-melanocyte signaling pathway. Clinical trials show 3% TA outperformed 4% hydroquinone by week 8. Pregnancy-safe and well-tolerated on sensitive skin.

70% Match
Discoloration Defense Dark Spot Serum
$108.00

Multi-acid blend (tranexamic acid 3%, kojic acid 1%, niacinamide 5%, HEPES) targets pigmentation via multiple pathways. Hydroquinone-free, ochronosis-free, safe for long-term daily use.

12

Comparison with competitors

SIDE-BY-SIDE

Tri-Luma (Fluocinolone/Hydroquinone/Tretinoin)

Key Actives HQ 4% + Tretinoin + Steroid
Size 30g
Access Prescription Only
Pregnancy Safe No (tretinoin contraindicated)
Drugs.com Rating 7.5/10 (92 reviews)
Time to Results 2-4 weeks
Nu-Derm Clear
Key Active Arbutin 7% + Vitamin C
Size 2 oz
Access Available OTC / Provider
Pregnancy Safe Generally considered safe
Hydroquinone Derivative Yes (safer alternative)
Time to Results 8-12 weeks
Rapid Dark Spot Correcting Serum
Key Actives Hexylresorcinol 2% + Tranexamic
Size 1 oz (30ml)
Access OTC (Sephora, Ulta)
Pregnancy Safe Yes
Hydroquinone-Free Yes
Time to Results Claimed 2 weeks; full in 8 weeks
13

Storage & shelf life

3 MONTHS
Period After Opening (PAO)

3 months of active use recommended; discard by expiration date on tube. Darkening of product is normal but reduces potency over time.

Storage

Store at controlled room temperature 20-25°C (68-77°F). Brief excursions 15-30°C (59-86°F) permitted. Keep cap tightly closed.

Packaging

1 oz (28.35g) aluminum tube with screw cap — standard pharmaceutical-grade packaging that limits oxidation exposure.

Travel Friendly

Yes — 28.35g tube is well under the 100ml TSA limit. Carry your prescription label when flying internationally.

13

Frequently asked questions

FAQ

No. The safety of topical hydroquinone during pregnancy or while breastfeeding has not been established. Hydroquinone is absorbed systemically (around 35-45%) and animal studies have shown some carcinogenic and mutagenic potential. It is not known whether hydroquinone is excreted in human milk. Dermatologists typically recommend discontinuing hydroquinone at least a month before conception and switching to pregnancy-safe alternatives like azelaic acid, vitamin C, or glycolic acid during pregnancy and lactation.

Yes. The formula does not contain fatty acids or esters with chain lengths of C11-C24 that feed Malassezia yeast, nor does it contain polysorbates or ferments. Squalane is considered fungal-acne safe, and mineral oil is inert. The only potential concern is the emulsifier PEG-40 Stearate, which is generally considered low-risk for malassezia folliculitis. Overall it's a low-risk choice for those managing fungal acne alongside hyperpigmentation.

Yes, but carefully. Retinoids (like tretinoin or retinol) are frequently combined with hydroquinone — in fact, Tri-Luma (4% HQ + 0.05% tretinoin + steroid) is a proven prescription combination. However, layering irritants can increase redness and dryness. Vitamin C (L-ascorbic acid) can be used in the morning while hydroquinone is used at night. AHAs and BHAs should be used on alternate nights, not stacked, to avoid barrier damage. Always space applications 15-30 minutes apart and introduce one new active at a time. Consult your dermatologist for a tailored regimen.

This cream performs best on mature, sun-damaged, and normal-to-dry skin with localized hyperpigmentation such as melasma, age spots, or post-inflammatory dark marks. The vanishing cream base works across most skin types but may feel too heavy for very oily complexions. Sensitive and rosacea-prone skin should approach with caution — start with every-other-night application and build up tolerance gradually. Hydroquinone treats all Fitzpatrick skin types, but darker skin tones (IV-VI) should be monitored more closely for exogenous ochronosis.

Most users notice subtle fading between weeks 3 and 4, with visibly significant improvement by weeks 6 to 8. Clinical studies on 4% hydroquinone demonstrated statistically significant reductions in mMASI (melasma severity) scores from the 4-week mark onward. Peak results are typically achieved at 12 weeks. If you see no improvement after 2 months, the package insert recommends discontinuation. Results depend heavily on consistent twice-daily application and strict daily SPF 30+ use — without sunscreen, results stall or reverse.

Apply hydroquinone as a targeted spot treatment after cleansing and any water-based toners or serums, but before moisturizer. In the morning: cleanser → toner → hydroquinone (on spots only) → moisturizer → broad-spectrum SPF 30+ (non-negotiable). In the evening: cleanser → hydroquinone (on spots only) → moisturizer. If using a retinoid, apply hydroquinone first, wait 10-15 minutes, then apply the retinoid. Keep it as a dedicated spot treatment rather than an all-over face cream to minimize unnecessary exposure.

It has a mild-to-moderate comedogenic rating of approximately 3/5, primarily due to the mineral oil, stearic acid, and glyceryl stearate base. However, pharmaceutical-grade mineral oil in this formulation has a low real-world clogging risk. Acne-prone users should apply it only to affected hyperpigmented spots rather than spreading it over the entire face, and pair it with a lightweight, non-comedogenic moisturizer. If new breakouts appear after starting treatment, reduce frequency to once daily or every other night.

Once opened, aim to use within 3 months for maximum potency, and always before the expiration date printed on the tube. Hydroquinone oxidizes rapidly when exposed to air and light, which is why the formula includes sodium metabisulfite as a stabilizer. Mild darkening of the cream is normal and doesn't affect safety, but a pronounced brown or black color indicates significant oxidation and loss of efficacy — discard at that point. Always close the cap tightly after each use and store away from heat and direct light.

— Skincarisma verdict
4.0 / 5 ★★★★☆

Verdict: Perrigo Hydroquinone 4% Cream remains the dermatology gold-standard treatment for stubborn melasma, post-inflammatory hyperpigmentation, and age spots. Its minimalist 11-ingredient formula delivers maximum prescription-strength hydroquinone without fragrance, dyes, or unnecessary fillers. Clinical studies consistently show 4% hydroquinone outperforms kojic acid and matches or beats tranexamic acid for fast, visible fading within 4-8 weeks. The trade-offs are real: prescription access, strict sunscreen requirements, pregnancy incompatibility, and a 3-month usage ceiling to avoid ochronosis. For those who qualify and commit to proper use, it's one of the most effective topical treatments available — though modern alternatives like azelaic acid, tranexamic acid, and arbutin offer safer long-term options for maintenance.

Product Overview

question
lightbulb What are Quick Product Notes?

Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.

muscle Pro Tip Alert!

Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.

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Quick Product Notes

Click on icons for more information
question
lightbulb What are Notable Effects & Ingredients?

Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging «promises» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.

We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.

muscle Pro Tip Alert!

Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.

Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you

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Notable Effects & Ingredients

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Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.

We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.

muscle Pro Tip Alert!

A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.

One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!

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Ingredients Related to Skin Types

Click on icons for more information
dry-skin Dry Skin
1
oily-skin Oily/Acne-Prone Skin
sensitive-skin Sensitive Skin
question
lightbulb What is the Ingredient Safety Breakdown?

Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.

muscle Pro Tip Alert!

EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.

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Ingredient Safety Breakdown

EWG Health Ratings
Low risk
Medium risk
High risk
Unknown risk
36% 9% 9% 45%

Product ingredient list

Showing first 5 of 11 ingredients
EWG CIR Ingredient Name & Cosmetic Functions Notes
1 A
Glyceryl Stearate
Emollient, Emulsifying
0 Unknown
Paraffinum Liquidum
Emollient, Skin Protecting, Solvent
0 Unknown
PEG-40 Stearate
Emulsifying
3 B
Propylene Glycol
Solvent, Skin Conditioning, Fragrance, Humectant, Viscosity Controlling, Viscosity Decreasing Agent, Skin-Conditioningagent - Miscellaneous
Hydrating
7 A
Propylparaben
Perfuming, Fragrance, Preservative
VIEW ALL INGREDIENTS