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Hypochlorous Acid Daily Facial Mist

Hypochlorous Acid Daily Facial Mist

Product Description

Product overview

Made in Various INTERNATIONAL

A pH-balanced facial mist powered by 150ppm Hypochlorous Acid and 2% Niacinamide that soothes redness, purifies pores, and delivers lightweight hydration. Clinically tested to inhibit 96.3% of acne-causing C. acnes bacteria, this versatile spray works after cleansing, over makeup, post-workout, or anytime skin needs calming relief.

Non-Comedogenic 0.00% Irritation Index Pregnancy Safe Fungal Acne Safe Fragrance-Free Paraben-Free Silicone-Free Sulfate-Free Clinically Tested pH-Balanced
Pregnancy
Yes
Fungal Acne
Yes
Comedogenic
0/5
Size
125ml / 4.22 fl.oz
Type
Facial Mist / Toner
Key Active
HOCl 150ppm
Concern
Acne & Redness
PAO
6 Months
Real reviews · YouTube Shorts
Why it's different

96.3% Bacterial Inhibition

Clinically verified to reduce C. acnes bacteria on the skin at 50% concentration, helping prevent and soothe breakouts.

01

Texture & feel

SENSORY
Consistency
Watery Mist
Scent
Fragrance-Free
Absorption
Instant (air dry)
Finish
Dewy / Fresh

96.3% Bacterial Inhibition

Clinically verified to reduce C. acnes bacteria on the skin at 50% concentration, helping prevent and soothe breakouts.

Skin Barrier Support

Shown to improve the skin barrier by 13.2% after just one use. Niacinamide and panthenol strengthen the moisture barrier over time.

Natural Defense Booster

HOCl is naturally produced by your body's white blood cells. This mist supplements your skin's own immune defense system.

Versatile Anytime Use

Spray after cleansing, over makeup, post-workout, during travel, or anytime skin needs a soothing refresh without disruption.

02

Safety & compatibility

SAFE
Pregnancy & Breastfeeding Safe

No retinoids, salicylic acid, hydroquinone, or chemical sunscreens. All ingredients are considered safe during pregnancy and breastfeeding. Always consult your doctor.

Fungal Acne (Malassezia) Safe

Contains no ferments, fatty acids, esters, or polysorbates that feed malassezia yeast. Confirmed fungal acne safe by SkinSort ingredient analysis.

Non-Comedogenic (0/5)

Clinically tested with a 0.00% irritation index. Lightweight watery formula does not clog pores or contribute to breakouts.

Retinol & Active Compatible

Safe to layer with retinol, vitamin C, AHA, and BHA. HOCl can help soothe irritation caused by strong actives. Apply before or after actives.

Contains Essential Oils

Includes eucalyptus, rosemary, and tea tree leaf oils in small amounts for antibacterial benefit. May cause sensitivity in very reactive skin types. Patch test recommended.

pH-Balanced Formula

Stabilized with sodium citrate and citric acid to maintain optimal pH for HOCl efficacy and skin compatibility.

03

Ingredient breakdown

INGREDIENTS

Hypochlorous Acid (HOCl) 150ppmProven

A powerful antimicrobial naturally produced by your white blood cells to fight infection. At 150ppm, it effectively purifies skin, kills acne-causing bacteria, and reduces inflammation without irritating or drying the skin.

  • Clinical: 96.33% inhibition rate against C. acnes at 50% concentration
  • Mechanism: Disrupts bacterial cell membranes while being biocompatible with human tissue
  • Safety: Used in wound care and post-surgical settings; FDA-cleared in medical devices
HOCl is one of the gentlest yet most effective antimicrobials available in skincare. Safe for daily use on all skin types including sensitive and eczema-prone skin.

Niacinamide (Vitamin B3) 2%Proven

A well-researched multifunctional ingredient that improves uneven skin tone, reduces pore appearance, and strengthens the skin barrier. At 2%, it provides visible brightening benefits without the irritation risk of higher concentrations.

  • Brightening: Inhibits melanosome transfer to reduce hyperpigmentation and dark spots
  • Barrier: Increases ceramide synthesis for stronger, healthier skin
  • Sebum: Helps regulate oil production at concentrations as low as 2%

Panthenol (Pro-Vitamin B5)Proven

A humectant and skin-conditioning agent that attracts and retains moisture. Converts to pantothenic acid (vitamin B5) in the skin, promoting wound healing and reducing irritation from other ingredients.

  • Hydration: Draws water into the skin and prevents transepidermal water loss
  • Healing: Promotes fibroblast proliferation, aiding skin repair and collagen production
  • Soothing: Proven anti-inflammatory that reduces irritation from actives and environmental stressors

AllantoinProven

A gentle soothing and moisturizing agent known for its protective properties. Helps calm irritation and supports skin healing, making it ideal for sensitive and compromised skin.

  • Soothing: Reduces redness and irritation on contact
  • Protection: Forms a protective layer that shields skin from environmental damage

Tea Tree Leaf OilProven

A well-established essential oil with strong antibacterial, antiviral, and antifungal properties. Works synergistically with HOCl to combat acne-causing bacteria. Present in a low concentration for antibacterial benefit without significant irritation risk.

  • Anti-Acne: Studies show 5% TTO is comparable to 5% benzoyl peroxide for treating acne
  • Antifungal: Effective against a wide range of fungi and yeasts
Essential oils including tea tree, eucalyptus, and rosemary are present in small amounts. Those with very sensitive or reactive skin should patch test first.

17 ingredients

Water, Niacinamide, Butylene Glycol, Hydroxyacetophenone, Panthenol, Octyldodeceth-16, C12-14 Alketh-12, Sodium Gluconate, Sodium Citrate, Ethylhexylglycerin, Allantoin, Citric Acid, Hypochlorous Acid (150ppm), Eucalyptus Globulus Leaf Oil, Rosmarinus Officinalis (Rosemary) Leaf Oil, Melaleuca Alternifolia (Tea Tree) Leaf Oil, Sodium Chloride

FREE FROM: Parabens, Silicones, Sulfates, Harsh Alcohols, Added Fragrance, Mineral Oil, Formaldehyde, Phthalates, Hydroquinone, Retinoids, Phenoxyethanol
04

Where it fits in your routine

ROUTINE
1
Cleanser
2
This Mist
3
Toner
4
Serum
5
Moisturizer
6
Sunscreen

Use AM & PM after cleansing, or spritz anytime throughout the day over makeup, after workouts, or during travel. Can also be applied between any skincare steps for an extra calming boost.

05

How to use

HOW TO USE
1

Cleanse Your Face

Start with clean skin. Use your regular cleanser to remove makeup, sunscreen, and impurities.

2

Close Eyes & Spray

Hold the bottle at a comfortable distance (about 15-20cm) from your face. Close your eyes and mist 3-5 sprays evenly across your face and neck.

3

Let It Air Dry

Allow the mist to absorb and air dry naturally. Do not rub or pat in. The fine mist settles quickly without leaving residue.

4

Continue Your Routine

Follow with toner, serum, moisturizer, and sunscreen (AM). Use morning and evening, or spritz anytime your skin needs a soothing refresh.

06

Who is it for?

WHO

Perfect for you if:

  • You struggle with acne, breakouts, or clogged pores
  • Your skin gets red, irritated, or inflamed easily
  • You want a soothing post-workout or post-sun refresh
  • You need a gentle antibacterial step without harsh ingredients
  • You have a compromised or weakened skin barrier
  • You wear masks regularly and experience maskne
  • You are pregnant or breastfeeding and need safe acne care

Consider alternatives if:

  • You need intense hydration (this is a lightweight mist, not a heavy moisturizer)
  • You are highly sensitive to essential oils (contains tea tree, eucalyptus, rosemary)
  • You want a strong anti-aging treatment with retinol or peptides
  • You prefer a non-spray format (this is exclusively a mist)
07

Skin type compatibility

SKIN TYPES
Oily Skin
Excellent

Ultra-lightweight watery mist adds zero oiliness. HOCl helps control acne-causing bacteria and niacinamide regulates sebum production.

Dry Skin
Good

Provides light hydration via panthenol and allantoin, but dry skin types will need a richer moisturizer layered on top for sufficient moisture.

Combination Skin
Excellent

Balances beautifully across oily and dry zones. Purifies the T-zone without stripping drier areas. Ideal all-over mist for mixed skin.

Sensitive Skin
Good

Tested at 0.00% irritation index and pH-balanced. Contains small amounts of essential oils, so patch test if extremely reactive.

Acne-Prone Skin
Excellent

Non-comedogenic, fungal acne safe, and clinically proven to inhibit 96.3% of C. acnes bacteria. Ideal daily defense for breakout-prone skin.

08

Results timeline

MONTH 2+
Immediately

Instant Soothing & Barrier Boost

Skin feels refreshed and calm on contact. The fine mist delivers a cooling sensation that reduces the feeling of irritation. Clinical testing showed a 13.2% skin barrier improvement after just one application.

Noticeable from first use
Week 1-2

Reduced Redness & Fewer New Breakouts

Visible calming of redness and inflammation as HOCl continuously reduces bacterial load on the skin surface. Existing breakouts begin to heal faster.

5.48% redness improvement (clinical study)
Week 2-4

Clearer, More Even Complexion

With consistent daily use, skin appears clearer and more balanced. Niacinamide begins visibly evening skin tone. Dry, flaky patches noticeably reduce.

52.4% improvement in dry/flaky skin
Month 2+

Strengthened Barrier & Long-Term Clarity

Cumulative benefits become apparent with a stronger skin barrier, fewer recurring breakouts, improved skin texture, and a more consistent, healthy-looking glow.

Best results with continued daily use
09

Ratings by platform

580+ REVIEWS
Amazon
4.6
Rating
450+
Reviews
Main complaint: Bottle runs out quickly with frequent daily use; some wish for a larger size option
Ulta Beauty
5.0
Rating
4+
Reviews
Main complaint: Limited reviews so far; newer product on the platform
StyleKorean
4.7
Rating
26+
Reviews
Main complaint: Shipping time from Korea can take 1-3 weeks depending on location
Medicube US
4.8
Rating
100+
Reviews
Main complaint: Some users wish the spray nozzle produced an even finer mist
10

Pros & cons

BALANCED

Praised

  • Clinically proven antibacterial activity (96.3% against C. acnes)
  • Extremely gentle with 0.00% irritation index
  • Versatile use: face, body, over makeup, post-workout
  • Clean, minimal 17-ingredient formula
  • Fungal acne safe and non-comedogenic
  • Pregnancy and breastfeeding safe
  • Soothes redness and irritation on contact
  • Contains niacinamide for added brightening and barrier support

Criticized

  • 125ml bottle can run out fast with heavy daily use
  • Contains essential oils (eucalyptus, rosemary, tea tree) that may bother very sensitive skin
  • HOCl has a limited shelf life; effectiveness decreases after opening
  • Lightweight formula alone may not provide enough hydration for very dry skin
  • Higher price per ml compared to some basic HOCl sprays
11

Budget-friendly alternatives (dupes)

DUPES
65% Match
Topical Skin Spray
$15.95
Budget Pick

Pure HOCl spray (0.014%) with only 3 ingredients: electrolyzed water, sea salt, and hypochlorous acid. Much simpler formula without niacinamide, panthenol, or allantoin. Larger 240ml bottle at a lower price, but lacks the skin-conditioning and brightening benefits of Medicube.

60% Match
Antimicrobial Facial Cleanser for Acne
$16.99
Budget Pick

Contains 0.018% HOCl with ionized water and salt. Marketed more as a facial cleanser than a toner/mist. No niacinamide or soothing agents. Larger 8 fl.oz bottle is great value, but primarily focuses on antibacterial action without the skincare extras.

50% Match
Curativa Bay Advanced Hypochlorous Skin Spray
$21.00
Similar Price

Higher HOCl concentration (0.02%) in a simple electrolyzed water + salt formula. 237ml bottle. Good for overall skin health but, like other pure HOCl sprays, lacks the multi-active approach (niacinamide, panthenol, allantoin) that Medicube offers.

12

Comparison with competitors

SIDE-BY-SIDE
SOS Daily Rescue Facial Spray
HOCl Concentration 0.015%
Bonus Actives None (only electrolyzed water + salt)
Total Ingredients 3
Size 120ml (4 fl.oz)
Price per oz $7.00/oz
Fungal Acne Safe Yes
Clinical Testing Limited
Topical Skin Spray
HOCl Concentration 0.014%
Bonus Actives None (only electrolyzed water + salt)
Total Ingredients 3
Size 240ml (8 fl.oz)
Price per oz $1.99/oz
Fungal Acne Safe Yes
Clinical Testing NIH tested purity

Active Skin Repair Spray

HOCl Concentration 0.012%
Bonus Actives Sodium Hypochlorite, Phosphates
Total Ingredients 5
Size 88ml (3 fl.oz)
Price per oz $8.33/oz
Fungal Acne Safe Yes
Clinical Testing Wound care focused
13

Storage & shelf life

6 MONTHS
Period After Opening (PAO)

6 months after opening. HOCl naturally degrades over time, so use promptly after opening for maximum efficacy.

Storage

Store in a cool, dry place away from direct sunlight and heat. Refrigeration is not required but can extend freshness. Keep cap sealed when not in use.

Packaging

Opaque spray bottle with fine mist nozzle. The opaque container helps protect HOCl from light degradation.

Travel Friendly

Yes, the 125ml size exceeds the 100ml carry-on limit. A 50ml travel size (1.69 fl.oz) is available and TSA-approved for flights.

13

Frequently asked questions

FAQ

Yes. This product contains no retinoids, salicylic acid, hydroquinone, chemical sunscreens, or any other ingredients flagged as unsafe during pregnancy or breastfeeding. Hypochlorous acid is naturally produced by the human body and is considered safe for topical use. Niacinamide and panthenol are also pregnancy-safe. As always, consult your OB-GYN or dermatologist before introducing new products during pregnancy.

Yes. This product is confirmed fungal acne (malassezia) safe by SkinSort ingredient analysis. It contains no ferments, fatty acids, esters, or polysorbates that feed the malassezia yeast responsible for fungal acne. In fact, the HOCl and tea tree oil may actively help fight fungal overgrowth thanks to their antimicrobial properties.

Yes. Hypochlorous acid is compatible with all common actives including retinol, vitamin C (ascorbic acid), AHAs (glycolic, lactic acid), and BHAs (salicylic acid). In fact, using this mist before or after strong actives can help soothe and calm the skin, reducing the irritation and redness that actives sometimes cause. There are no known negative interactions. Simply spray the mist, let it air dry, then apply your actives as usual.

This mist is formulated for all skin types and is especially well-suited for oily, combination, and acne-prone skin. It was clinically tested with a 0.00% irritation index, making it appropriate for sensitive skin as well. Dry skin types will benefit from the soothing and barrier-boosting properties but should follow with a richer moisturizer. It is ideal for anyone dealing with breakouts, redness, irritation, maskne, or a compromised skin barrier.

Many users notice an immediate soothing and refreshing effect from the first spray. Clinical studies showed a 13.2% skin barrier improvement after just one use. Visible reduction in redness (5.48%) was observed after 2 weeks of consistent use. For significant improvement in breakouts, skin clarity, and overall texture, expect to see noticeable results within 2-4 weeks of daily AM/PM use.

Use it immediately after cleansing as the first step in your routine, before toner, serum, and moisturizer. It can also be used anytime throughout the day — over makeup, after workouts, during travel, or whenever your skin needs a calming refresh. The beauty of this mist is its versatility: there is no wrong time to use it.

No. This product has been clinically tested and confirmed non-comedogenic with a 0.00% irritation index. It has a comedogenic rating of 0 out of 5. The lightweight watery mist contains no heavy oils, silicones, or pore-clogging ingredients. It is specifically designed for acne-prone and breakout-prone skin and is safe for daily use without risk of clogging pores.

Hypochlorous acid naturally degrades over time, so it is recommended to use this product within 6 months of opening for best results. The formula is stabilized with sodium citrate and citric acid to help maintain freshness and pH balance, but efficacy will gradually decrease. Store in a cool, dry place away from direct sunlight and keep the cap sealed when not in use.

— Skincarisma verdict
4.5 / 5 ★★★★★

Verdict: The Medicube Hypochlorous Acid Daily Facial Mist stands out in the crowded HOCl spray market thanks to its multi-active formula. While competitors like Tower 28 and Briotech offer pure HOCl-and-salt sprays, Medicube goes further by adding 2% niacinamide, panthenol, and allantoin for brightening, barrier support, and soothing hydration. Backed by clinical data showing 96.3% bacterial inhibition and 13.2% barrier improvement, it delivers real results. The only drawbacks are the relatively small 125ml bottle size for the price, the 6-month PAO due to HOCl instability, and the inclusion of essential oils that may not suit the most reactive skin types. Overall, an excellent daily-use mist for anyone battling acne, redness, or irritation — especially if you want more than just antibacterial action from your HOCl spray.

Product Overview

question
lightbulb What are Quick Product Notes?

Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.

muscle Pro Tip Alert!

Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.

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Quick Product Notes

Click on icons for more information
question
lightbulb What are Notable Effects & Ingredients?

Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging «promises» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.

We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.

muscle Pro Tip Alert!

Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.

Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you

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Notable Effects & Ingredients

anti-aging Anti-Aging from 2 ingredient(s):
Niacinamide Citric Acid
brightening Brightening from 2 ingredient(s):
Niacinamide Citric Acid
wound Promotes Wound Healing from 4 ingredient(s):
Niacinamide Panthenol Allantoin Citric Acid
ache Ache-fighting from 2 ingredient(s):
Niacinamide Hypochlorous Acid
question
lightbulb What are Ingredients Related to Skin Type?

Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.

We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.

muscle Pro Tip Alert!

A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.

One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!

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Ingredients Related to Skin Types

Click on icons for more information
dry-skin Dry Skin
2
oily-skin Oily/Acne-Prone Skin
3
sensitive-skin Sensitive Skin
1
question
lightbulb What is the Ingredient Safety Breakdown?

Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.

muscle Pro Tip Alert!

EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.

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Ingredient Safety Breakdown

EWG Health Ratings
Low risk
Medium risk
High risk
Unknown risk
70% 29%

Product ingredient list

Showing first 5 of 17 ingredients
EWG CIR Ingredient Name & Cosmetic Functions Notes
1 Unknown
Water
Solvent, Skin Conditioning
1 A
Niacinamide
Skin Conditioning, Hair Conditioning, Smoothing
brightening Brightening
ache Ache-fighting
anti-aging Anti-Aging
Promotes Wound Healing
Redness
Irritation
Dark Spots
Pores
1 A
Butylene Glycol
Solvent, Skin Conditioning, Masking, Fragrance, Humectant, Viscosity Controlling, Viscositydecreasing Agent
Hydrating
0 Unknown
Hydroxyacetophenone
Irritation
1 A
Panthenol
Skin Conditioning, Antistatic Agent, Hair Conditioning
Promotes Wound Healing
Hydrating
Redness
Irritation
VIEW ALL INGREDIENTS