Hypochlorous Acid Daily Facial Mist
Hypochlorous Acid Daily Facial Mist
Product Description
Product overview
A pH-balanced facial mist powered by 150ppm Hypochlorous Acid and 2% Niacinamide that soothes redness, purifies pores, and delivers lightweight hydration. Clinically tested to inhibit 96.3% of acne-causing C. acnes bacteria, this versatile spray works after cleansing, over makeup, post-workout, or anytime skin needs calming relief.
96.3% Bacterial Inhibition
Clinically verified to reduce C. acnes bacteria on the skin at 50% concentration, helping prevent and soothe breakouts.
Texture & feel
SENSORY96.3% Bacterial Inhibition
Clinically verified to reduce C. acnes bacteria on the skin at 50% concentration, helping prevent and soothe breakouts.
Skin Barrier Support
Shown to improve the skin barrier by 13.2% after just one use. Niacinamide and panthenol strengthen the moisture barrier over time.
Natural Defense Booster
HOCl is naturally produced by your body's white blood cells. This mist supplements your skin's own immune defense system.
Versatile Anytime Use
Spray after cleansing, over makeup, post-workout, during travel, or anytime skin needs a soothing refresh without disruption.
Safety & compatibility
SAFENo retinoids, salicylic acid, hydroquinone, or chemical sunscreens. All ingredients are considered safe during pregnancy and breastfeeding. Always consult your doctor.
Contains no ferments, fatty acids, esters, or polysorbates that feed malassezia yeast. Confirmed fungal acne safe by SkinSort ingredient analysis.
Clinically tested with a 0.00% irritation index. Lightweight watery formula does not clog pores or contribute to breakouts.
Safe to layer with retinol, vitamin C, AHA, and BHA. HOCl can help soothe irritation caused by strong actives. Apply before or after actives.
Includes eucalyptus, rosemary, and tea tree leaf oils in small amounts for antibacterial benefit. May cause sensitivity in very reactive skin types. Patch test recommended.
Stabilized with sodium citrate and citric acid to maintain optimal pH for HOCl efficacy and skin compatibility.
Ingredient breakdown
INGREDIENTSHypochlorous Acid (HOCl) 150ppmProven
A powerful antimicrobial naturally produced by your white blood cells to fight infection. At 150ppm, it effectively purifies skin, kills acne-causing bacteria, and reduces inflammation without irritating or drying the skin.
- Clinical: 96.33% inhibition rate against C. acnes at 50% concentration
- Mechanism: Disrupts bacterial cell membranes while being biocompatible with human tissue
- Safety: Used in wound care and post-surgical settings; FDA-cleared in medical devices
Niacinamide (Vitamin B3) 2%Proven
A well-researched multifunctional ingredient that improves uneven skin tone, reduces pore appearance, and strengthens the skin barrier. At 2%, it provides visible brightening benefits without the irritation risk of higher concentrations.
- Brightening: Inhibits melanosome transfer to reduce hyperpigmentation and dark spots
- Barrier: Increases ceramide synthesis for stronger, healthier skin
- Sebum: Helps regulate oil production at concentrations as low as 2%
Panthenol (Pro-Vitamin B5)Proven
A humectant and skin-conditioning agent that attracts and retains moisture. Converts to pantothenic acid (vitamin B5) in the skin, promoting wound healing and reducing irritation from other ingredients.
- Hydration: Draws water into the skin and prevents transepidermal water loss
- Healing: Promotes fibroblast proliferation, aiding skin repair and collagen production
- Soothing: Proven anti-inflammatory that reduces irritation from actives and environmental stressors
AllantoinProven
A gentle soothing and moisturizing agent known for its protective properties. Helps calm irritation and supports skin healing, making it ideal for sensitive and compromised skin.
- Soothing: Reduces redness and irritation on contact
- Protection: Forms a protective layer that shields skin from environmental damage
Tea Tree Leaf OilProven
A well-established essential oil with strong antibacterial, antiviral, and antifungal properties. Works synergistically with HOCl to combat acne-causing bacteria. Present in a low concentration for antibacterial benefit without significant irritation risk.
- Anti-Acne: Studies show 5% TTO is comparable to 5% benzoyl peroxide for treating acne
- Antifungal: Effective against a wide range of fungi and yeasts
17 ingredients
Water, Niacinamide, Butylene Glycol, Hydroxyacetophenone, Panthenol, Octyldodeceth-16, C12-14 Alketh-12, Sodium Gluconate, Sodium Citrate, Ethylhexylglycerin, Allantoin, Citric Acid, Hypochlorous Acid (150ppm), Eucalyptus Globulus Leaf Oil, Rosmarinus Officinalis (Rosemary) Leaf Oil, Melaleuca Alternifolia (Tea Tree) Leaf Oil, Sodium Chloride
Where it fits in your routine
ROUTINEUse AM & PM after cleansing, or spritz anytime throughout the day over makeup, after workouts, or during travel. Can also be applied between any skincare steps for an extra calming boost.
How to use
HOW TO USECleanse Your Face
Start with clean skin. Use your regular cleanser to remove makeup, sunscreen, and impurities.
Close Eyes & Spray
Hold the bottle at a comfortable distance (about 15-20cm) from your face. Close your eyes and mist 3-5 sprays evenly across your face and neck.
Let It Air Dry
Allow the mist to absorb and air dry naturally. Do not rub or pat in. The fine mist settles quickly without leaving residue.
Continue Your Routine
Follow with toner, serum, moisturizer, and sunscreen (AM). Use morning and evening, or spritz anytime your skin needs a soothing refresh.
Who is it for?
WHOPerfect for you if:
- You struggle with acne, breakouts, or clogged pores
- Your skin gets red, irritated, or inflamed easily
- You want a soothing post-workout or post-sun refresh
- You need a gentle antibacterial step without harsh ingredients
- You have a compromised or weakened skin barrier
- You wear masks regularly and experience maskne
- You are pregnant or breastfeeding and need safe acne care
Consider alternatives if:
- You need intense hydration (this is a lightweight mist, not a heavy moisturizer)
- You are highly sensitive to essential oils (contains tea tree, eucalyptus, rosemary)
- You want a strong anti-aging treatment with retinol or peptides
- You prefer a non-spray format (this is exclusively a mist)
Skin type compatibility
SKIN TYPESUltra-lightweight watery mist adds zero oiliness. HOCl helps control acne-causing bacteria and niacinamide regulates sebum production.
Provides light hydration via panthenol and allantoin, but dry skin types will need a richer moisturizer layered on top for sufficient moisture.
Balances beautifully across oily and dry zones. Purifies the T-zone without stripping drier areas. Ideal all-over mist for mixed skin.
Tested at 0.00% irritation index and pH-balanced. Contains small amounts of essential oils, so patch test if extremely reactive.
Non-comedogenic, fungal acne safe, and clinically proven to inhibit 96.3% of C. acnes bacteria. Ideal daily defense for breakout-prone skin.
Results timeline
MONTH 2+Instant Soothing & Barrier Boost
Skin feels refreshed and calm on contact. The fine mist delivers a cooling sensation that reduces the feeling of irritation. Clinical testing showed a 13.2% skin barrier improvement after just one application.
Noticeable from first useReduced Redness & Fewer New Breakouts
Visible calming of redness and inflammation as HOCl continuously reduces bacterial load on the skin surface. Existing breakouts begin to heal faster.
5.48% redness improvement (clinical study)Clearer, More Even Complexion
With consistent daily use, skin appears clearer and more balanced. Niacinamide begins visibly evening skin tone. Dry, flaky patches noticeably reduce.
52.4% improvement in dry/flaky skinStrengthened Barrier & Long-Term Clarity
Cumulative benefits become apparent with a stronger skin barrier, fewer recurring breakouts, improved skin texture, and a more consistent, healthy-looking glow.
Best results with continued daily useRatings by platform
580+ REVIEWSPros & cons
BALANCEDPraised
- Clinically proven antibacterial activity (96.3% against C. acnes)
- Extremely gentle with 0.00% irritation index
- Versatile use: face, body, over makeup, post-workout
- Clean, minimal 17-ingredient formula
- Fungal acne safe and non-comedogenic
- Pregnancy and breastfeeding safe
- Soothes redness and irritation on contact
- Contains niacinamide for added brightening and barrier support
Criticized
- 125ml bottle can run out fast with heavy daily use
- Contains essential oils (eucalyptus, rosemary, tea tree) that may bother very sensitive skin
- HOCl has a limited shelf life; effectiveness decreases after opening
- Lightweight formula alone may not provide enough hydration for very dry skin
- Higher price per ml compared to some basic HOCl sprays
Budget-friendly alternatives (dupes)
DUPESPure HOCl spray (0.014%) with only 3 ingredients: electrolyzed water, sea salt, and hypochlorous acid. Much simpler formula without niacinamide, panthenol, or allantoin. Larger 240ml bottle at a lower price, but lacks the skin-conditioning and brightening benefits of Medicube.
Contains 0.018% HOCl with ionized water and salt. Marketed more as a facial cleanser than a toner/mist. No niacinamide or soothing agents. Larger 8 fl.oz bottle is great value, but primarily focuses on antibacterial action without the skincare extras.
Higher HOCl concentration (0.02%) in a simple electrolyzed water + salt formula. 237ml bottle. Good for overall skin health but, like other pure HOCl sprays, lacks the multi-active approach (niacinamide, panthenol, allantoin) that Medicube offers.
Comparison with competitors
SIDE-BY-SIDEActive Skin Repair Spray
Storage & shelf life
6 MONTHS6 months after opening. HOCl naturally degrades over time, so use promptly after opening for maximum efficacy.
Store in a cool, dry place away from direct sunlight and heat. Refrigeration is not required but can extend freshness. Keep cap sealed when not in use.
Opaque spray bottle with fine mist nozzle. The opaque container helps protect HOCl from light degradation.
Yes, the 125ml size exceeds the 100ml carry-on limit. A 50ml travel size (1.69 fl.oz) is available and TSA-approved for flights.
Frequently asked questions
FAQYes. This product contains no retinoids, salicylic acid, hydroquinone, chemical sunscreens, or any other ingredients flagged as unsafe during pregnancy or breastfeeding. Hypochlorous acid is naturally produced by the human body and is considered safe for topical use. Niacinamide and panthenol are also pregnancy-safe. As always, consult your OB-GYN or dermatologist before introducing new products during pregnancy.
Yes. This product is confirmed fungal acne (malassezia) safe by SkinSort ingredient analysis. It contains no ferments, fatty acids, esters, or polysorbates that feed the malassezia yeast responsible for fungal acne. In fact, the HOCl and tea tree oil may actively help fight fungal overgrowth thanks to their antimicrobial properties.
Yes. Hypochlorous acid is compatible with all common actives including retinol, vitamin C (ascorbic acid), AHAs (glycolic, lactic acid), and BHAs (salicylic acid). In fact, using this mist before or after strong actives can help soothe and calm the skin, reducing the irritation and redness that actives sometimes cause. There are no known negative interactions. Simply spray the mist, let it air dry, then apply your actives as usual.
This mist is formulated for all skin types and is especially well-suited for oily, combination, and acne-prone skin. It was clinically tested with a 0.00% irritation index, making it appropriate for sensitive skin as well. Dry skin types will benefit from the soothing and barrier-boosting properties but should follow with a richer moisturizer. It is ideal for anyone dealing with breakouts, redness, irritation, maskne, or a compromised skin barrier.
Many users notice an immediate soothing and refreshing effect from the first spray. Clinical studies showed a 13.2% skin barrier improvement after just one use. Visible reduction in redness (5.48%) was observed after 2 weeks of consistent use. For significant improvement in breakouts, skin clarity, and overall texture, expect to see noticeable results within 2-4 weeks of daily AM/PM use.
Use it immediately after cleansing as the first step in your routine, before toner, serum, and moisturizer. It can also be used anytime throughout the day — over makeup, after workouts, during travel, or whenever your skin needs a calming refresh. The beauty of this mist is its versatility: there is no wrong time to use it.
No. This product has been clinically tested and confirmed non-comedogenic with a 0.00% irritation index. It has a comedogenic rating of 0 out of 5. The lightweight watery mist contains no heavy oils, silicones, or pore-clogging ingredients. It is specifically designed for acne-prone and breakout-prone skin and is safe for daily use without risk of clogging pores.
Hypochlorous acid naturally degrades over time, so it is recommended to use this product within 6 months of opening for best results. The formula is stabilized with sodium citrate and citric acid to help maintain freshness and pH balance, but efficacy will gradually decrease. Store in a cool, dry place away from direct sunlight and keep the cap sealed when not in use.
Verdict: The Medicube Hypochlorous Acid Daily Facial Mist stands out in the crowded HOCl spray market thanks to its multi-active formula. While competitors like Tower 28 and Briotech offer pure HOCl-and-salt sprays, Medicube goes further by adding 2% niacinamide, panthenol, and allantoin for brightening, barrier support, and soothing hydration. Backed by clinical data showing 96.3% bacterial inhibition and 13.2% barrier improvement, it delivers real results. The only drawbacks are the relatively small 125ml bottle size for the price, the 6-month PAO due to HOCl instability, and the inclusion of essential oils that may not suit the most reactive skin types. Overall, an excellent daily-use mist for anyone battling acne, redness, or irritation — especially if you want more than just antibacterial action from your HOCl spray.
Product Overview
Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.
Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.
Quick Product Notes
Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging «promises» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.
We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.
Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.
Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you
Notable Effects & Ingredients
Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.
We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.
A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.
One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!
Ingredients Related to Skin Types
Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.
EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.
Ingredient Safety Breakdown
Product ingredient list
| EWG | CIR | Ingredient Name & Cosmetic Functions | Notes |
|---|---|---|---|
| 1 |
Water
Solvent, Skin Conditioning
|
|
|
| 1 |
Niacinamide
Skin Conditioning, Hair Conditioning, Smoothing
|
Promotes Wound Healing
Redness
Irritation
Dark Spots
Pores
|
|
| 1 |
Butylene Glycol
Solvent, Skin Conditioning, Masking, Fragrance, Humectant, Viscosity Controlling, Viscositydecreasing Agent
|
Hydrating
|
|
| 0 |
Hydroxyacetophenone
|
Irritation
|
|
| 1 |
Panthenol
Skin Conditioning, Antistatic Agent, Hair Conditioning
|
Promotes Wound Healing
Hydrating
Redness
Irritation
|





