Mandelic Serum 5%
Mandelic Serum 5%
Product Description
A gentle yet powerful exfoliating serum by Lissy Skincare, formulated with 5% L-Mandelic Acid alongside Niacinamide, Lactic Acid, Hyaluronic Acid, Glycerin, and Licorice Root Extract. Designed by a licensed Master Esthetician to tackle acne, fungal acne, hyperpigmentation, and dull skin while staying safe for all skin tones, sensitive skin, and use throughout pregnancy and breastfeeding.
β¨ Texture & Feel
Gentle Exfoliation at 5%
L-Mandelic Acid's larger molecular size means it penetrates slowly and evenly, delivering effective AHA exfoliation with far less irritation than glycolic or lactic acid β ideal for beginners and sensitive skin.
Fights Acne & Fungal Acne
Mandelic acid's natural antibacterial and antifungal properties make this serum one of the few exfoliants that address both bacterial acne and Malassezia-related fungal acne in a single formula.
Brightens & Fades Marks
Niacinamide teams up with Licorice Root Extract (Glycyrrhiza Glabra) to visibly reduce post-acne hyperpigmentation, dark spots, and uneven tone over time without bleaching agents.
Hydrating While Exfoliating
Hyaluronic Acid, Glycerin, Sodium PCA, and Sodium Lactate provide multi-layer hydration, preventing the dryness and irritation commonly associated with exfoliating acids.
Safe for Pregnancy & Breastfeeding
Formulated without retinoids, hydroquinone, salicylic acid, or chemical sunscreens. The brand confirms all ingredients are generally considered safe for topical use during pregnancy when applied in small amounts.
Esthetician-Formulated
Created by Lissy, a licensed Master Esthetician who struggled with acne for years. Every ingredient is chosen with purpose β no fillers, no harsh additives, no parabens, and no sulfates.
π‘οΈ Safety & Compatibility
Contains no retinoids, hydroquinone, salicylic acid, or chemical sunscreens. The brand states all ingredients are generally safe for topical use during pregnancy. Always confirm with your healthcare provider.
Confirmed fungal acne safe by third-party analysis on SkinSort. Contains no ferments, fatty acid esters, polysorbates, or oils that feed Malassezia yeast. Safe for pityrosporum folliculitis.
No oils, silicones, or pore-clogging ingredients. The formula is lightweight and water-based, making it extremely unlikely to clog pores. Rated 1 out of 5 on the comedogenic scale.
Contains no added fragrances, essential oils, common allergens, parabens, sulfates, or harsh alcohols. Suitable for reactive and sensitized skin types.
Mandelic and lactic acids increase photosensitivity. Always apply SPF 30+ the following morning. Best used as part of a PM routine. Avoid if you skip sunscreen.
Some users report a 1β2 week purging phase as the acid accelerates cell turnover and brings congestion to the surface. This is normal and typically resolves as skin adjusts.
Mandelic acid is widely recommended for deeper skin tones because its slower absorption minimizes post-inflammatory hyperpigmentation risk compared to glycolic acid.
No oxybenzone, octinoxate, or marine-harmful ingredients. Formula is 100% vegan β no animal-derived ingredients β and cruelty-free with no animal testing at any stage.
π¬ Ingredient Breakdown
π L-Mandelic Acid 5% Proven
The star active in this serum. L-Mandelic Acid is an alpha hydroxy acid (AHA) derived from bitter almonds. Its larger molecular size (152 Da vs glycolic acid's 76 Da) means slower, more even skin penetration β making it significantly gentler while still delivering effective exfoliation, antibacterial, and antifungal benefits.
- Mechanism: Breaks desmosomes (bonds between dead skin cells), accelerating natural cell turnover to reveal brighter, smoother skin
- Acne: Antibacterial action inhibits P. acnes bacteria; antifungal properties simultaneously address Malassezia overgrowth
- Hyperpigmentation: Inhibits tyrosinase enzyme activity, reducing melanin overproduction and fading post-acne marks
- Skin Tone: Studies indicate mandelic acid is safer than glycolic acid for darker skin tones due to reduced inflammation risk
π Niacinamide est. 2β4% Proven
Vitamin B3 in its most bioavailable form. Niacinamide is one of the most well-researched skincare actives β a true multi-tasker that strengthens the skin barrier, controls sebum, minimizes pores, and fades dark spots, all while being exceptionally well-tolerated by sensitive skin.
- Barrier support: Stimulates ceramide and fatty acid synthesis in the stratum corneum, improving moisture retention
- Brightening: Inhibits melanosome transfer from melanocytes to keratinocytes, visibly reducing hyperpigmentation
- Anti-acne: Reduces sebum excretion rates and calms acne-related inflammation
- Pore appearance: Firms skin around pores and reduces their visible size over 8β12 weeks of consistent use
π₯ Lactic Acid est. 1β3% Proven
A secondary AHA derived from milk (though this formula is vegan, so it's likely synthetically derived or fermentation-derived). Lactic acid is larger than glycolic acid and gentler, making it ideal as a supporting exfoliant. It also acts as a humectant, attracting moisture to the skin while it exfoliates.
- Exfoliation: Loosens corneocyte bonds to promote faster, smoother cell shedding at low concentrations
- Hydration: Acts as a natural moisturizing factor (NMF) component, boosting the skin's own hydration capacity
- Smoothing: Improves texture and softness with consistent use, complementing mandelic acid's deeper exfoliating action
π§ Sodium Hyaluronate (Hyaluronic Acid) est. 0.1β1% Proven
The sodium salt form of hyaluronic acid β smaller molecular weight than standard HA, allowing deeper penetration into the epidermis. It binds up to 1,000x its weight in water, delivering intensive, lasting hydration that counteracts any dryness from the exfoliating acids.
- Hydration: Attracts and retains water molecules in the skin, plumping fine lines and improving skin resilience
- Barrier support: Forms a moisture-holding film on the skin surface while also hydrating from within
- Irritation buffer: Helps soothe and calm skin during the adjustment period when starting acid exfoliation
π Glycerin est. 1β5% Proven
A powerhouse humectant naturally found in healthy skin. Glycerin draws moisture from the environment and deeper skin layers to the outer skin surface. Research shows it may outperform AHAs and hyaluronic acid as a pure humectant, making it one of the most effective moisturizing ingredients available.
- Humectancy: Draws moisture from the dermis and external environment into the epidermis
- Barrier repair: Supports lamellar body secretion, helping restore lipid-depleted skin barriers
- Low comedogenicity: Rated 0β1 on the comedogenic scale; safe for acne-prone skin
πΏ Glycyrrhiza Glabra Root Extract (Licorice Root) est. <1% Proven
Licorice root extract, standardized for its key active glabridin and glycyrrhizin. A powerfully soothing and brightening botanical with a strong safety record. A natural alternative to kojic acid and hydroquinone for hyperpigmentation.
- Brightening: Glabridin inhibits UVB-induced pigmentation and tyrosinase activity β reducing dark spots without harsh bleaching
- Anti-inflammatory: Glycyrrhizin blocks pro-inflammatory enzymes (phospholipase A2, cyclooxygenase), calming redness and irritation
- Antioxidant: Neutralizes free radicals that accelerate pigmentation and skin aging
12 ingredients
Water, L-Mandelic Acid, Lactic Acid, Sodium PCA, Niacinamide, Sodium Hyaluronate, Sodium Lactate, Glycerin, Witch Hazel Extract (Hamamelis Virginiana Leaf Extract), Licorice Root Extract (Glycyrrhiza Glabra Root Extract), Camellia Extract (Camellia Sinensis Leaf Extract), Xanthan Gum
π Where It Fits in Your Routine
Best used in your PM routine after cleansing and toning. Apply before heavier serums, creams, and oils. Follow with a non-comedogenic moisturizer to lock in hydration. Always wear SPF 30+ the following morning.
π How to Use
Cleanse Thoroughly
Start with a gentle, non-stripping cleanser to remove makeup, SPF, and impurities. Pat skin dry β do not apply to wet skin as this can increase irritation.
Apply Toner (Optional)
If using a hydrating or balancing toner, apply it first and allow it to absorb for 30 seconds before continuing to the serum.
Dispense 3β5 Drops
Pump or pour 3β5 drops of the Mandelic Serum 5% onto clean fingertips. A little goes a long way β avoid using excessive amounts, especially when starting out.
Press Into Skin
Gently press and pat the serum across your face and neck, avoiding the eye area. Do not rub β pressing helps absorption and minimizes potential irritation.
Follow with Moisturizer
Apply a non-comedogenic moisturizer over the serum to seal in hydration and support your skin barrier. This is especially important during the first 2β4 weeks of use.
Apply SPF Every Morning
AHA exfoliants increase photosensitivity. Apply SPF 30 or higher every morning β rain or shine β to protect your freshly revealed skin and prevent new sun-induced pigmentation.
π€ Who Is It For?
β Perfect for you if:
- You struggle with hormonal, cystic, or fungal acne
- You have post-acne marks, uneven tone, or dull skin
- You have sensitive skin that reacts to glycolic acid
- You are pregnant or breastfeeding and need a safe acid
- You have deeper skin tone and want to avoid PIH risk
- You are new to chemical exfoliation and want a gentle start
- You want an all-in-one exfoliant, brightener, and hydrator
β Consider alternatives if:
- You skip sunscreen daily (AHAs require SPF protection)
- You have an active sunburn or broken skin barrier
- You want a higher-strength acid (8β10%) for severe cases
- You are already using tretinoin or strong retinoids nightly
- You are looking for a physical/mechanical exfoliant
π― Skin Type Compatibility
Mandelic acid regulates sebum production and unclogs pores. Niacinamide further controls oil shine. The lightweight, water-based formula absorbs without adding greasiness.
Directly targets bacterial and fungal acne causes. Non-comedogenic rating of 1/5. Fades post-acne marks with niacinamide and licorice root. Hundreds of verified customer transformations.
Mandelic acid's large molecule size makes it the gentlest AHA available. Fragrance-free and allergen-free formula. Start every other night and patch test first. Discontinue if persistent irritation occurs.
Exfoliates congested areas while hydrating dry patches. Niacinamide balances sebum in the T-zone without over-drying cheeks. A versatile workhorse for mixed skin needs.
Lactic acid and glycerin add hydration while exfoliating. Best paired with a richer moisturizer on top. May need to limit use to 2β3x per week to prevent over-exfoliation of already dry skin.
π Results Timeline
Skin Adjustment & Possible Purge
As cell turnover accelerates, some users experience a temporary purge where congestion is brought to the surface. Skin may feel slightly tingly on application. This is normal and should not be confused with a reaction.
~30% experience mild purgingSmoother Texture & Fewer Breakouts
Dead skin cells exfoliate away revealing noticeably smoother skin. Active breakouts begin to decrease in frequency and severity. Skin starts to look clearer and feel softer to the touch.
~70% notice texture improvementVisible Brightening & Pore Refinement
Post-acne marks begin to fade as niacinamide and licorice root inhibit melanin transfer. Pore appearance improves. Skin tone looks more even and radiant. Most users see their clearest skin by week 5.
~80% see significant clearingSustained Clarity & Long-Term Results
Consistent use delivers cumulative benefits. Acne scarring fades progressively, overall tone becomes dramatically more even, and the skin's barrier strengthens. Many users describe this as a long-term skin transformation.
~90% would repurchaseβ Ratings by Platform
βοΈ Pros & Cons
β Praised
- Effective against both bacterial acne and fungal acne
- Pregnancy and breastfeeding safe β rare for an exfoliating serum
- Gentle enough for sensitive and reactive skin
- Fragrance-free, allergen-free, vegan, and cruelty-free
- Hydrating formula β doesn't strip or over-dry skin
- Safe for all skin tones including deeper complexions
- Impressive before-and-after results shared by community
- Esthetician-formulated with clean, purposeful ingredients
- Non-comedogenic β won't clog pores
β Criticized
- Premium price at ~$52 for 50ml
- Initial 1β2 week purging period surprises some users
- Only available at 5% concentration (no stronger option)
- Requires daily SPF commitment to use safely
- International shipping costs can be high
- Not widely available in physical retail stores
π° Budget-Friendly Alternatives (Dupes)
Higher mandelic acid concentration (10%) but lacks niacinamide and licorice root brighteners. Anhydrous formula with a different texture. Can be harsh for sensitive skin. Not explicitly certified pregnancy or fungal acne safe by the brand.
Also fungal acne safe and vegan with a clean formula. Uses phytic acid and gluconolactone alongside mandelic acid. However, it lacks niacinamide and licorice root β meaning less brightening and pore-refining action. Smaller bottle.
Wider availability in US retailers. Higher 12% concentration for more experienced acid users. Includes squalane for extra hydration. However, higher concentration increases irritation risk for sensitive skin, and not branded as pregnancy safe.
π Comparison with Competitors
Lissy Skincare Mandelic Serum 5% β Featured
$52.00The Ordinary Mandelic Acid 10% + HA
~$9.90Good Molecules Mandelic Acid Serum
~$12.00Naturium Mandelic Topical Acid 12%
~$22.00π¦ Storage & Shelf Life
12 months after opening. Use consistently within one year for best potency and efficacy of active acids.
Store in a cool, dry place away from direct sunlight and heat. Do not refrigerate unless noted. Keep out of reach of children.
50ml / 1.7 fl oz pump or dropper bottle. Minimizes air exposure to preserve acid potency. Clean, no-frills packaging consistent with the brand's esthetician-first ethos.
Yes β at 50ml / 1.7 fl oz, it meets most airline carry-on liquid requirements (under 100ml). Compact enough to fit in any toiletry bag.
β Frequently Asked Questions
Yes. The Lissy Skincare Mandelic Serum 5% is considered safe to use during pregnancy and breastfeeding. The formula contains no retinoids, hydroquinone, salicylic acid, or chemical sunscreens β the ingredients most commonly flagged as unsafe during pregnancy. The brand states on their website that all ingredients are generally considered safe for topical use during pregnancy when applied in small amounts. As always, consult with your OB-GYN or midwife before adding any new skincare product during pregnancy, especially those containing active acids.
Yes. This is one of the standout features of this serum. It is confirmed fungal acne safe by independent third-party ingredient analysis on SkinSort. The formula contains no fatty acid esters, ferments, oils, polysorbates, or other ingredients known to feed Malassezia yeast. Furthermore, mandelic acid itself has documented antifungal properties, making this serum one of the only exfoliants that can actively help treat fungal acne (pityrosporum folliculitis) rather than simply not worsening it.
It depends on the ingredient. Avoid using this serum on the same night as retinol, tretinoin, or other AHA/BHA exfoliants (such as glycolic acid or salicylic acid toners), as this can cause over-exfoliation, irritation, and barrier damage. You can alternate nights β mandelic serum on some evenings, retinol on others. With Vitamin C (L-ascorbic acid), it's generally fine to use them in separate routines (e.g. vitamin C in the morning, mandelic serum at night), or layer vitamin C first if it's a stable derivative at a neutral pH. Always patch test and introduce new actives slowly.
The Mandelic Serum 5% is suitable for all skin types and is particularly excellent for oily, acne-prone, and combination skin. It is also a top choice for sensitive skin types that cannot tolerate stronger acids like glycolic acid. Because mandelic acid has a large molecular size and penetrates slowly, it is far less likely to cause stinging, redness, or irritation. It is also specifically recommended for deeper skin tones, as it carries less risk of causing post-inflammatory hyperpigmentation than glycolic acid. Dry skin types can use it too, though a richer moisturizer afterward is recommended.
Most users begin noticing smoother skin texture within the first 2β3 weeks of consistent use. Visible reduction in active breakouts typically occurs by weeks 3β5. Significant fading of post-acne marks and improvement in overall skin tone is usually apparent by weeks 6β8. Some users report a brief purging phase during the first 1β2 weeks where congestion surfaces before clearing β this is a normal part of the cell turnover process. For best results, use consistently every evening and always wear SPF the next morning. Full skin transformation typically takes 8β12 weeks of regular use.
Apply the Mandelic Serum 5% as your first active serum step after cleansing and toning, before any heavier serums, moisturizers, or facial oils. The general rule for layering is thinnest-to-thickest texture. This serum is best used in your PM (nighttime) routine because AHA acids increase photosensitivity β always follow with SPF 30 or higher the next morning. Full routine order: Cleanser β Toner (optional) β Mandelic Serum 5% β Other Serums β Moisturizer β (AM only) SPF 30+.
No. The Mandelic Serum 5% is non-comedogenic with a very low comedogenic rating of 1 out of 5. The formula contains no oils, silicones, waxes, or pore-clogging ingredients. It is entirely water-based and lightweight. In fact, mandelic acid's exfoliating action actively helps to decongest clogged pores by breaking down the buildup of dead skin cells and sebum that leads to blackheads, whiteheads, and closed comedones. This makes it an excellent choice for acne-prone individuals specifically concerned about pore congestion.
The Mandelic Serum 5% has a Period After Opening (PAO) of 12 months. Once opened, use within one year for optimal potency. The efficacy of mandelic acid and other active ingredients can diminish over time when exposed to air and light. To maximize shelf life: store in a cool, dry place away from direct sunlight, keep the cap tightly sealed after each use, and avoid introducing water or contaminants into the bottle. At a typical usage rate of 3β5 drops per evening, a 50ml bottle lasts approximately 3β5 months, well within the PAO window.
Verdict: The Lissy Skincare Mandelic Serum 5% earns its place as one of the most thoughtfully formulated exfoliating serums on the indie beauty market. By pairing 5% L-Mandelic Acid with Niacinamide, Lactic Acid, Hyaluronic Acid, Glycerin, and Licorice Root Extract, it delivers a rare combination β effective exfoliation, brightening, hydration, and acne control in a single lightweight serum. What sets it apart is its accessibility: safe for pregnant and breastfeeding individuals, confirmed fungal acne safe, gentle enough for sensitive skin and deeper skin tones, and free from nearly every common skincare irritant. The price reflects premium formulation and esthetician expertise, and the community results speak for themselves. If you are battling acne, fungal acne, post-acne marks, or uneven texture and want one serum that works gently but effectively, this is it.
Product Overview
Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.
Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.
Quick Product Notes
Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging Β«promisesΒ» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.
We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.
Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.
Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you
Notable Effects & Ingredients
Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.
We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.
A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.
One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!
Ingredients Related to Skin Types
Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.
EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.
Ingredient Safety Breakdown
Product ingredient list
| EWG | CIR | Ingredient Name & Cosmetic Functions | Notes |
|---|---|---|---|
| 1 |
Mandelic Acid
Antimicrobial
|
|
|
| 1 |
Niacinamide
Skin Conditioning, Hair Conditioning, Smoothing
|
Promotes Wound Healing
Redness
Irritation
Dark Spots
Pores
|
|
| 0 |
Lactic Acid
|
|
|
| 0 |
Hyaluronic Acid
Humectant, Moisturising, Skin Conditioning
|
Promotes Wound Healing
Hydrating
|
|
| 2 |
Glycerin
Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant, Skin Conditioning
|
Promotes Wound Healing
Hydrating
|

