Mix-01 Serum
Mix-01 Serum
Product Description
Product overview
A multifunctional anti-acne treatment serum combining four powerhouse actives — 5% Niacinamide, 4% Glycolic Acid, 3% Tranexamic Acid, and 2% Salicylic Acid — in a lightweight, oil-free formula that targets breakouts, blackheads, dark spots, excess oil, and enlarged pores all at once.
4-in-1 Active Powerhouse
Combines AHA, BHA, niacinamide, and tranexamic acid in a single serum for multi-target treatment of acne, pigmentation, and texture.
Texture & feel
SENSORY4-in-1 Active Powerhouse
Combines AHA, BHA, niacinamide, and tranexamic acid in a single serum for multi-target treatment of acne, pigmentation, and texture.
Oil-Free Mattifying Formula
Lightweight, fast-absorbing texture disappears into skin with zero residue — perfect for oily and combination skin types.
Clinically-Backed Concentrations
Each active is dosed at scientifically effective percentages: 5% niacinamide, 4% glycolic, 3% tranexamic, 2% salicylic acid.
Minimalist Clean Formula
Only 15 ingredients. Free from parabens, silicones, fragrance, dyes, petrolatum, and gluten. No unnecessary fillers.
Exceptional Value
Often called "the Brazilian Ordinary" for delivering high-performance actives at a fraction of luxury brand pricing.
Suitable for All Skin Types
Formulated for universal compatibility. Particularly effective for oily, combination, and acne-prone skin.
Safety & compatibility
SAFENot recommended. Contains 2% salicylic acid (BHA), which is generally advised against during pregnancy. Glycolic acid may also increase skin sensitivity. Consult your OB/GYN before use.
No oils, fatty acids, esters, ferments, or polysorbates. The formula contains no ingredients known to feed Malassezia yeast.
Comedogenic rating 0/5. Completely oil-free and silicone-free formula will not clog pores or contribute to breakouts.
Contains AHA (glycolic acid) and BHA (salicylic acid) which increase photosensitivity. Use only in the evening and apply broad-spectrum SPF 30+ every morning.
May cause temporary tingling, mild burning, or dryness during the first week. Start on alternate nights and gradually increase to nightly use.
According to the brand, there are virtually no restrictions on combining Mix-01 with other actives. However, avoid layering with additional strong acids or retinol on the same night.
Ingredient breakdown
INGREDIENTSNiacinamide (Vitamin B3) 5%Proven
A multitasking form of vitamin B3 that strengthens the skin barrier, regulates sebum production, reduces pore appearance, fades dark spots, and improves overall skin texture. One of the most well-researched and versatile skincare actives.
- Sebum Control: Studies show 5% niacinamide significantly reduces sebum excretion rate after 4 weeks of use.
- Barrier Support: Boosts ceramide synthesis and strengthens the lipid barrier, reducing transepidermal water loss.
- Pigmentation: Inhibits melanosome transfer from melanocytes to keratinocytes, helping to fade dark spots over time.
Glycolic Acid (AHA) 4%Proven
The smallest and most penetrating alpha hydroxy acid, derived from sugar cane. Dissolves the bonds between dead skin cells to accelerate cell turnover, revealing smoother, brighter skin underneath. Stimulates collagen production over time.
- Exfoliation: Its small molecular size (76 Da) allows deeper penetration than other AHAs for effective chemical exfoliation.
- Cell Renewal: Promotes natural regeneration by accelerating the shedding of dead skin cells.
- Pore Refinement: Clears dead cell buildup from pore walls, helping minimize their visible appearance.
Tranexamic Acid 3%Promising
A synthetic amino acid derivative originally used in medicine to reduce bleeding. In skincare, it inhibits melanin production by blocking the plasminogen/plasmin pathway, making it a powerful brightening agent for stubborn hyperpigmentation and post-inflammatory marks.
- Hyperpigmentation: Clinical trials show significant improvement in melasma and post-inflammatory hyperpigmentation with topical use at 2-5%.
- Gentle Brightening: Works differently than hydroquinone with a much lower risk of irritation or rebound pigmentation.
- Synergy: Works synergistically with niacinamide for enhanced brightening and anti-inflammatory effects.
Salicylic Acid (BHA) 2%Proven
The gold standard beta hydroxy acid for acne-prone skin. Unlike AHAs, salicylic acid is oil-soluble, allowing it to penetrate deep into pores to dissolve sebum plugs, reduce inflammation, and prevent new breakouts from forming.
- Pore Penetration: Oil-soluble nature allows it to work inside clogged pores where AHAs cannot reach.
- Anti-Inflammatory: Structurally related to aspirin, providing soothing and anti-inflammatory benefits to irritated, acne-prone skin.
- FDA Recognized: 2% is the maximum OTC concentration recognized by the U.S. FDA for topical acne treatment.
Sodium Hyaluronate <1%Proven
The sodium salt form of hyaluronic acid with a smaller molecular weight, allowing deeper skin penetration. Attracts and holds up to 1,000 times its weight in water, providing hydration to counterbalance the drying effects of the acids in this formula.
- Hydration: Acts as a powerful humectant, drawing moisture from the environment into the skin layers.
- Barrier Support: Helps maintain skin hydration and plumpness even while using exfoliating acids.
15 ingredients
Aqua, Xanthan Gum, Propanediol, Ethoxydiglycol, Sodium Hyaluronate, Sodium Hydroxide, Niacinamide, Tranexamic Acid, Citric Acid, Glycolic Acid, Salicylic Acid, Benzyl Alcohol, Benzoic Acid, Dehydroacetic Acid, Alcohol
Where it fits in your routine
ROUTINEUse in the PM only. Apply on clean, dry skin before heavier products. 89% of community routines use this serum in the evening as step 3.
How to use
HOW TO USECleanse Your Face
Start with clean, dry skin. Remove all makeup and impurities with a gentle cleanser and pat dry completely.
Dispense a Few Drops
Without touching the cannula to the skin, dispense 3-4 drops onto your fingertips or directly onto your face.
Spread Gently
Gently spread the serum evenly over your entire face, avoiding the eye area, eyelids, and outer corners of the nose and mouth.
Follow with Moisturizer
Allow the serum to absorb for 1-2 minutes, then apply a hydrating moisturizer suited to your skin type to lock in benefits.
Apply Sunscreen in the Morning
The next morning, always apply a broad-spectrum sunscreen SPF 30+ to protect skin from UV sensitivity caused by acids.
Who is it for?
WHOPerfect for you if:
- You struggle with acne, blackheads, and clogged pores
- You have oily or combination skin with excess shine
- You want to fade dark spots and post-acne marks
- You prefer a minimalist, multi-active approach
- You are looking for an affordable yet effective acid serum
- You want a fragrance-free, clean formula
Consider alternatives if:
- You are pregnant or breastfeeding (contains salicylic acid)
- You have very dry or dehydrated skin without oiliness
- You are extremely sensitive and cannot tolerate any acids
- You are already using multiple strong acid products
- You need a morning serum (this is PM-only due to photosensitivity)
Skin type compatibility
SKIN TYPESIdeal match. BHA and niacinamide work together to control sebum, while the oil-free formula absorbs instantly without adding shine.
Lightweight fluid balances well across oily and dry zones. AHA/BHA combo addresses T-zone congestion without over-drying cheeks.
Non-comedogenic, fungal-acne safe, oil-free formula with both AHA and BHA to clear existing breakouts and prevent new ones.
Good for refining texture and brightening, though the full acid combo may be more than normal skin needs. Can use 2-3 times per week.
Fragrance-free is a plus, but the 4-acid combination may cause stinging or redness. Start very slowly and apply hyaluronic acid underneath to buffer.
AHA and BHA can exacerbate dryness. If you do use it, limit to 1-2 nights per week and always follow with a rich moisturizer.
Results timeline
WEEK 8-12Initial Adjustment & Purging
Mild tingling and possible purging as acids accelerate cell turnover and bring underlying congestion to the surface. Skin may appear slightly drier as it adjusts.
Common for first-time acid usersSmoother Texture & Reduced Oiliness
Skin texture begins to feel noticeably smoother and softer. Sebum production starts to normalize. Blackheads visibly diminish as BHA clears pore congestion.
97% noticed reduced oiliness by day 30Visible Brightening & Fewer Breakouts
Dark spots and post-acne marks start to fade thanks to tranexamic acid and niacinamide. Active breakouts are significantly reduced. Pore size appears minimized.
90% noticed improved radianceFull Results & Skin Transformation
Cumulative effects of all four actives reach peak performance. Skin appears clearer, brighter, and more even-toned. Firmness and elasticity noticeably improved.
83% noticed reduced pore sizeRatings by platform
11K+ REVIEWSPros & cons
BALANCEDPraised
- Four proven actives at effective concentrations in one serum
- Exceptional value — high-performance formula at a budget price
- Lightweight, fast-absorbing, non-greasy texture
- Visibly reduces blackheads and acne within weeks
- Clean, minimalist 15-ingredient formula
- Free from parabens, silicones, fragrance, dyes, and gluten
- Cruelty-free and vegan
- Fungal acne safe formulation
Criticized
- Noticeable alcohol scent that some find unpleasant
- Can cause stinging and burning on sensitive skin initially
- Small 30ml bottle may run out quickly
- PM-only use limits versatility
- Not pregnancy or breastfeeding safe
- Limited availability outside of Brazil
- May cause purging during the first 1-2 weeks
Budget-friendly alternatives (dupes)
DUPESShares the niacinamide for oil control and pore refinement, but lacks glycolic acid, tranexamic acid, and salicylic acid. You would need to layer separate acid products to replicate the full Mix-01 effect.
Contains both AHA (glycolic) and BHA (salicylic) for exfoliation and pore clearing. However, concentrations are lower, lacks niacinamide and tranexamic acid, and comes in a toner format rather than a treatment serum.
Combines niacinamide with tranexamic acid for brightening, but lacks the AHA/BHA exfoliating component. Better for pigmentation-only concerns without the acne-fighting power.
Focused on 2% salicylic acid (BHA) for pore clearing and acne treatment. Simpler formula that addresses only the BHA component of Mix-01 without AHA, niacinamide, or tranexamic acid.
Comparison with competitors
SIDE-BY-SIDEStorage & shelf life
6 MONTHS6 months after opening
Store in a cool, dry place away from direct sunlight. Keep tightly sealed after each use. No refrigeration required.
Amber glass bottle with dropper/cannula tip to protect light-sensitive active ingredients and ensure precise application.
Yes, 30ml is under the 100ml/3.4oz TSA carry-on limit. Glass bottle — pack carefully in toiletry bag.
Frequently asked questions
FAQNo. Principia Mix-01 contains 2% salicylic acid (BHA), which is generally recommended to avoid during pregnancy and breastfeeding. It also contains 4% glycolic acid (AHA), which may cause increased skin sensitivity. Most dermatologists advise against using BHA products while pregnant or nursing. Please consult your OB/GYN or dermatologist for personalized guidance.
Yes. Principia Mix-01 is fungal acne safe. Its formula contains no oils, fatty acids, fatty acid esters, ferments, or polysorbates — the common triggers that feed Malassezia yeast. The oil-free, silicone-free formula with only 15 ingredients makes it one of the cleanest options for fungal acne sufferers who also want acid exfoliation.
According to the brand, there are virtually no restrictions on using Mix-01 with other actives. However, since Mix-01 already contains both AHA (glycolic) and BHA (salicylic), layering additional acid exfoliants on the same night may cause excessive irritation. If you use retinol, alternate nights: Mix-01 one evening, retinol the next. Vitamin C is best used in the morning while Mix-01 is used at night.
Principia Mix-01 is best suited for oily, combination, and acne-prone skin types. Its oil-free, lightweight formula controls sebum, clears pores with salicylic acid, and smooths texture with glycolic acid. Those with normal skin can also benefit by using it 2-3 times per week. It may be too active for very dry or extremely sensitive skin without careful introduction.
Most users report smoother texture and reduced oiliness within 2-4 weeks. Visible improvement in blackheads and acne typically appears by week 4. Dark spot fading and improved radiance take 4-8 weeks. Full results including pore refinement and even tone are generally seen at the 8-12 week mark with consistent nightly use.
Apply Mix-01 as step 3 in your evening routine: (1) Cleanser, (2) Toner (optional), (3) Mix-01 Serum on clean, dry skin, (4) Moisturizer. In the morning, apply sunscreen. During the first week, use on alternate nights only. The brand recommends using it before creams, sunscreen, and makeup.
No. Principia Mix-01 has a comedogenic rating of 0/5. It is completely oil-free, silicone-free, and contains no known pore-clogging ingredients. In fact, the salicylic acid (BHA) in the formula actively works to unclog pores, while glycolic acid (AHA) clears dead cell buildup from pore walls. It is recommended for acne-prone skin.
Principia Mix-01 should be used within 6 months after opening (6M PAO). The amber glass bottle helps protect the active acids from light degradation. Store in a cool, dry place with the cap tightly sealed. If the product changes color, consistency, or develops an unusual odor, discontinue use.
Verdict: Principia Mix-01 delivers exceptional multi-active performance at an unbeatable price point. Combining four clinically-backed ingredients — niacinamide, glycolic acid, tranexamic acid, and salicylic acid — in a clean 15-ingredient formula, it effectively addresses acne, blackheads, dark spots, and oiliness simultaneously. The minimalist, oil-free formulation is ideal for oily and acne-prone skin types seeking a streamlined routine. While the strong alcohol scent and initial adjustment period may deter some users, the results speak for themselves: smoother texture, fewer breakouts, and visibly brighter skin within weeks. Often compared to The Ordinary for its transparent, no-frills approach, this Brazilian gem is a standout choice for anyone looking for maximum active performance without the premium price tag.
Product Overview
Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.
Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.
Quick Product Notes
Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging «promises» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.
We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.
Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.
Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you
Notable Effects & Ingredients
Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.
We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.
A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.
One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!
Ingredients Related to Skin Types
Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.
EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.
Ingredient Safety Breakdown
Product ingredient list
| EWG | CIR | Ingredient Name & Cosmetic Functions | Notes |
|---|---|---|---|
| 1 |
Water
Solvent, Skin Conditioning
|
|
|
| 1 |
Xanthan Gum
Binding Agent, Emulsion Stabilising, Skin Conditioning, Surfactant -Emulsifying Agent, Viscosity Increasing Agent, Binding, Gel Forming, Viscosity Controlling
|
|
|
| 1 |
Propanediol
Solvent, Viscosity Controlling, Viscosity Decreasing Agent
|
|
|
| 1 |
Ethoxydiglycol
Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent
|
|
|
| 1 |
Sodium Hyaluronate
Skin Conditioning, Humectant
|
Promotes Wound Healing
Hydrating
|









