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Modulating Glucosides

Modulating Glucosides

Product Description

Product overview

Made in Various INTERNATIONAL

A sophisticated concentrated emulsion featuring bio-active glucosides to target signs of skin sensitivity, redness, and irritation. This advanced formula supports barrier function, hydration, and general dermal repair while reducing stinging by up to 78% within 3 minutes of application.

Vegan Cruelty-Free Alcohol-Free Fragrance-Free Silicone-Free Paraben-Free 9 Advanced Technologies 11 Amino Acids
Pregnancy
Yes
Fungal Acne
No
Comedogenic
1/5
Size
30ml
Price
$35
pH Level
4.5-5.5
Ingredients
54
PAO
6 Months
Real reviews · YouTube Shorts
Why it's different

Bio-Active Glucosides Complex

Four plant-derived glucosides work synergistically to intercept sensitivity triggers and deliver potent antioxidant protection.

01

Texture & feel

SENSORY
Consistency
Lightweight Emulsion
Scent
Mild Chemical
Absorption
30-60 seconds
Finish
Slightly Dewy

Bio-Active Glucosides Complex

Four plant-derived glucosides work synergistically to intercept sensitivity triggers and deliver potent antioxidant protection.

Multi-Molecular Lipid Complex

Oat synthetic analogues, ceramides, and ginger root reduce signs of redness, itching, stinging, and burning.

SymSitive Technology

4-T-Butylcyclohexanol reduces stinging by 78% and burning by 80% within just 3 minutes of application.

11 Amino Acids

Comprehensive amino acid complex supports wound healing, barrier repair, and skin resilience.

02

Safety & compatibility

SAFE
Pregnancy & Breastfeeding Safe

No retinoids, salicylic acid, hydroquinone, or chemical sunscreens. Safe for use during pregnancy and breastfeeding.

Not Fungal Acne (Malassezia) Safe

Contains Caprylic/Capric Triglyceride, Stearic Acid, and Isodecyl Neopentanoate which may feed malassezia.

Low Comedogenic Risk

Rating 1/5. Squalane and glycerin are non-comedogenic. Suitable for most acne-prone skin types.

Retinol Compatible

Excellent companion for retinol/tretinoin users. Helps buffer irritation and supports barrier recovery.

Patch Test Recommended

Contains plant extracts. Patch test advised for those with plant allergies or extremely reactive skin.

Active Ingredient Compatible

Works well with Vitamin C, AHAs, BHAs, and other actives. Helps reduce irritation from strong treatments.

03

Ingredient breakdown

INGREDIENTS

Epigallocatechin Gallatyl GlucosideProven

A stabilized, glucose-modified form of EGCG from green tea. Provides powerful antioxidant and anti-inflammatory benefits while enhancing skin hydration through the attached glucose molecule.

  • Function: Antioxidant, anti-inflammatory, hydrating
  • Source: Green tea extract modified with glucose
  • Benefits: Reduces oxidative stress, calms inflammation, boosts hydration
Part of the signature 4-glucoside complex that gives this product its name and primary soothing action.

BisabololProven

The active soothing component derived from chamomile. Known for powerful anti-inflammatory properties that calm irritated, reactive skin.

  • Function: Anti-inflammatory, soothing, healing
  • Source: Chamomile plant (purified levomenol form)
  • Clinical Evidence: Extensively studied for reducing skin inflammation and redness

4-T-Butylcyclohexanol (SymSitive)Proven

A cutting-edge sensory modulator that intercepts irritation signals before they reach neuro-receptors, providing rapid relief from stinging and burning sensations.

  • Clinical Results: Reduces stinging by 78% and burning by 80% within 3 minutes
  • Mechanism: Blocks neuro-receptor signaling pathways
  • Benefit: Immediate comfort for sensitized skin

Squalane High PositionProven

A lightweight, skin-identical lipid that mimics natural sebum. Provides excellent hydration without clogging pores or leaving a greasy residue.

  • Comedogenic Rating: 0 (non-comedogenic)
  • Irritancy: 0 (non-irritating)
  • Benefits: Barrier repair, hydration, antioxidant protection

Palmitoyl Tripeptide-8Promising

A soothing peptide that helps calm skin reactivity and reduce visible signs of irritation. Offers immediate calming effects while supporting long-term skin resilience.

  • Function: Anti-inflammatory peptide
  • Mechanism: Modulates inflammatory response pathways
  • Benefit: Reduces redness and supports barrier function

Superoxide DismutaseProven

A powerful antioxidant enzyme naturally present in skin. Neutralizes free radicals and protects against oxidative stress that can trigger inflammation and premature aging.

  • Source: Yeast-derived
  • Function: Antioxidant, anti-inflammatory
  • Clinical Use: Used in medications for eczema and psoriasis

54 ingredients

Aqua (Water), Squalane, Isodecyl Neopentanoate, Glycerin, Caprylic/Capric Triglyceride, Pentylene Glycol, Propanediol, Hexyldecanol, Bisabolol, Butylene Glycol, Epigallocatechin Gallatyl Glucoside, Rosmarinyl Glucoside, Caffeyl Glucoside, Gallyl Glucoside, Tetrasodium Tetracarboxymethyl Naringeninchalcone, Hydroxymethoxyphenyl Decanone, 4-T-Butylcyclohexanol, Cetylhydroxyproline Palmitamide, Hydroxyphenyl Propamidobenzoic Acid, Palmitoyl Tripeptide-8, Superoxide Dismutase, Sodium PCA, PCA, Arginine, Glycine, Alanine, Serine, Valine, Isoleucine, Proline, Threonine, Histidine, Phenylalanine, Aspartic Acid, Sodium Lactate, Mirabilis Jalapa Callus Extract, Tasmannia Lanceolata Fruit/Leaf Extract, Zingiber Officinale (Ginger) Root Extract, Curculigo Orchioides Root Extract, Isochrysis Galbana Extract, Brassica Campestris (Rapeseed) Sterols, Stearic Acid, Dextran, Isoceteth-20, Polyacrylate Crosspolymer-6, Xanthan Gum, Tocopherol, Propyl Gallate, Tromethamine, Dehydroacetic Acid, 1,2-Hexanediol, Benzyl Alcohol, Phenoxyethanol

FREE FROM: Parabens, Sulfates, Mineral Oil, Silicones, Artificial Fragrances, Alcohol (Denatured), Essential Oils, Retinoids, Hydroquinone, Formaldehyde Releasers
04

Where it fits in your routine

ROUTINE
1
Cleanser
2
Toner
3
Actives/Acids
4
This Serum
5
Moisturizer
6
Sunscreen (AM)

If using with NIOD regimen, apply after CAIS (Copper Amino Isolate Serum) but before MMHC (Multi-Molecular Hyaluronic Complex). Use AM and PM.

05

How to use

HOW TO USE
1

Cleanse Your Skin

Start with a clean face using a gentle, non-stripping cleanser. Pat skin dry.

2

Apply a Few Drops

Using the dropper, dispense 3-4 drops onto fingertips. A little goes a long way with this concentrated formula.

3

Gently Press Into Skin

Apply to face and neck using gentle pressing motions. The lightweight emulsion absorbs quickly without rubbing.

4

Layer Additional Products

Wait 30-60 seconds for absorption, then follow with moisturizer. Apply SPF 30+ during daytime use.

06

Who is it for?

WHO

Perfect for you if:

  • You have sensitive, reactive, or redness-prone skin
  • You experience rosacea flare-ups or facial flushing
  • You're using retinoids/tretinoin and need barrier support
  • Your skin feels uncomfortable after using active ingredients
  • You want to strengthen your skin barrier long-term
  • You experience stinging, burning, or itching sensations
  • You're looking for a science-backed soothing treatment

Consider alternatives if:

  • You have fungal acne (malassezia folliculitis)
  • You prefer a water-based, ultra-lightweight texture
  • You have very oily skin and want a matte finish
  • You're sensitive to plant extracts
  • You need a longer PAO (product has 6-month shelf life)
  • You prefer fragrance-free products (has slight chemical scent)
07

Skin type compatibility

SKIN TYPES
Sensitive Skin
Excellent

Specifically designed for sensitive and reactive skin. Gentle formula with proven soothing ingredients.

Dry Skin
Excellent

Rich in squalane and glycerin for deep hydration. Emulsion texture provides lasting moisture.

Combination Skin
Good

Works well for combination skin, especially during winter. May feel slightly rich for oily zones in summer.

Oily Skin
Moderate

Emulsion texture may feel slightly rich for very oily skin. Can leave a dewy finish. Best used PM only.

Acne-Prone Skin
Good

Low comedogenic rating (1/5). Good for acne-prone skin, but avoid if you have fungal acne.

Rosacea-Prone
Excellent

Highly recommended for rosacea sufferers. Clinically formulated to reduce redness and visible irritation.

08

Results timeline

WEEK 8+
Immediate (3 min)

Stinging & Burning Relief

SymSitive technology provides rapid relief from sensory irritation. Skin feels noticeably calmer and more comfortable.

78% reduction in stinging
Week 1-2

Visible Redness Reduction

Daily use begins to reduce visible redness and reactive flare-ups. Skin appears calmer and more even-toned.

65% noticed improvement
Week 4-6

Barrier Strengthening

Skin barrier becomes notably stronger. Less reactive to environmental triggers and active ingredients.

80% reported calmer skin
Week 8+

Long-Term Resilience

Skin develops lasting resilience. Users report being able to tolerate stronger actives with less irritation.

90% would repurchase
09

Ratings by platform

850+ REVIEWS
NIOD / DECIEM Website
4.5
Rating
500+
Reviews
Main complaint: Scent is unusual (described as "paint-like"), short 6-month PAO
Amazon
4.3
Rating
150+
Reviews
Main complaint: Texture can feel heavy on oily skin, dropper packaging
Cult Beauty / Look Fantastic
4.7
Rating
200+
Reviews
Main complaint: Frequently out of stock, price point higher than The Ordinary alternatives
Beauty Blogs & Derms
4.5
Rating
Expert
Reviews
Main complaint: Complex ingredient list intimidating, "slow burner" product - effects build over time
10

Pros & cons

BALANCED

Praised

  • Highly effective for redness and sensitivity
  • Excellent companion for retinoid users
  • Science-backed formulation with 9 technologies
  • Noticeable calming effect within minutes
  • Supports long-term barrier health
  • Vegan and cruelty-free
  • Good value compared to prescription options
  • Works on sensitive, rosacea-prone skin

Criticized

  • Short 6-month shelf life after opening
  • Scent described as "paint-like" or chemical
  • Not fungal acne safe
  • Slightly heavy texture for oily skin
  • Dropper packaging can be messy
  • Results require consistent use over weeks
  • Complex ingredient list may intimidate beginners
  • Frequently sells out at retailers
11

Budget-friendly alternatives (dupes)

DUPES
85% Match
Soothing & Barrier Support Serum
$14.90
Budget Pick

Same parent company (DECIEM). Contains similar soothing glucosides but with fewer antioxidants. Simpler formula with niacinamide and centella. Great entry point for sensitive skin.

75% Match
Toleriane Ultra Dermallergo Serum
$28.00
Similar

French pharmacy alternative with Neurosensine technology. More watery texture preferred by oily skin types. Allergy-tested, fragrance-free. Less complex but still effective.

70% Match
Calm Repairing Serum
$38.00
Similar

Contains ceramides, licorice root, and willow herb. More gel-like texture. Also targets redness but with different actives. Better for those who want ceramide-focused barrier repair.

65% Match
Geek & Gorgeous Stress Less Serum
$12.00
Budget Pick

Simple centella-based formula. More lightweight and basic. Good for mild sensitivity but may not address severe reactivity as effectively as NIOD.

12

Comparison with competitors

SIDE-BY-SIDE
Soothing & Barrier Support Serum
Key Technology Centella + Niacinamide + Glucosides
Size 30ml (better value)
Texture Creamy emulsion
Barrier Support Good (simpler formula)
Fungal Acne Safe No
Calm Repairing Serum
Key Technology Ceramides + Licorice + Beta-Glucan
Size 30ml
Texture Lightweight gel (oily skin friendly)
Barrier Support Good (ceramide-focused)
Fungal Acne Safe No
Toleriane Ultra Dermallergo Serum
Key Technology Neurosensine + Thermal Water
Size 20ml
Texture Watery serum (very light)
Barrier Support Moderate
Fungal Acne Safe Yes
13

Storage & shelf life

6 MONTHS
Period After Opening (PAO)

6 months after opening. Mark the date when you first open the product to track usage.

Storage

Store in a cool, dry place away from direct sunlight. No refrigeration required but can be stored cool for a refreshing application.

Packaging

Dark glass dropper bottle. The amber glass helps protect light-sensitive ingredients from UV degradation.

Travel Friendly

Yes, under 100ml. TSA-approved carry-on size. Glass bottle requires careful packing.

13

Frequently asked questions

FAQ

Yes, NIOD Modulating Glucosides is considered safe during pregnancy and breastfeeding. The formula contains no retinoids, salicylic acid, hydroquinone, or chemical sunscreens. All active ingredients are soothing botanicals and peptides. However, always consult with your healthcare provider before adding new products to your routine during pregnancy.

No, this product is NOT fungal acne safe. It contains several ingredients that can potentially feed malassezia yeast, including Caprylic/Capric Triglyceride, Isodecyl Neopentanoate, and Stearic Acid. If you have fungal acne, consider alternatives like La Roche-Posay Toleriane Ultra Dermallergo Serum instead.

Absolutely! This serum is specifically designed to support skin when using active ingredients. It helps buffer irritation from retinoids, vitamin C, and exfoliating acids. Apply your actives first (after cleansing), then follow with Modulating Glucosides to soothe and protect. Many users report being able to tolerate stronger actives when using this product.

This product is best suited for sensitive, dry, and rosacea-prone skin types. It also works excellently for anyone using retinoids or strong actives. Those with oily skin may find the emulsion texture slightly rich and prefer using it only at night. Combination skin types generally do well with this product, especially in colder months.

You'll feel immediate soothing effects within 3 minutes of application thanks to the SymSitive technology. Visible reduction in redness typically appears within 1-2 weeks of consistent use. Significant barrier strengthening and long-term resilience develops over 4-8 weeks. This is a "slow burner" product that builds cumulative benefits with continued use.

Apply after cleansing, toning, and any water-based actives (like vitamin C serums or exfoliating acids). Apply before heavier creams, oils, and moisturizers. If using the NIOD regimen, apply after CAIS (Copper Amino Isolate Serum) but before MMHC (Multi-Molecular Hyaluronic Complex). Use both morning and evening for best results.

The product has a low comedogenic rating of 1/5. Key ingredients like squalane and glycerin are non-comedogenic (rated 0). While it contains some emollients, the overall formula is designed to be non-pore-clogging and is suitable for most acne-prone skin. However, patch testing is recommended for those highly prone to breakouts.

The product has a PAO (Period After Opening) of 6 months. This is shorter than many skincare products due to the active botanical ingredients. Mark the opening date on the bottle and try to use it within this timeframe. The 30ml size is designed to be used up within this period with twice-daily application.

— Skincarisma verdict
4.5 / 5 ★★★★★

Verdict: NIOD Modulating Glucosides is a sophisticated, science-backed treatment for sensitive and reactive skin. The combination of bio-active glucosides, SymSitive technology, and 11 amino acids delivers both immediate comfort and long-term barrier strengthening. It's particularly excellent for rosacea sufferers and retinoid users. The main drawbacks are the short 6-month shelf life, unusual scent, and incompatibility with fungal acne. For those with reactive skin looking for a research-driven solution, this is one of the most comprehensive options on the market. The price point is justified by the advanced formulation and clinical results.

Product Overview

question
lightbulb What are Quick Product Notes?

Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.

muscle Pro Tip Alert!

Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.

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Quick Product Notes

Click on icons for more information
question
lightbulb What are Notable Effects & Ingredients?

Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging «promises» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.

We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.

muscle Pro Tip Alert!

Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.

Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you

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Notable Effects & Ingredients

anti-aging Anti-Aging from 3 ingredient(s):
Superoxide Dismutase Histidine Tocopherol
brightening Brightening from 1 ingredient(s):
Glycerin
wound Promotes Wound Healing from 6 ingredient(s):
Glycerin Arginine Histidine Phenylalanine Zingiber Officinale Root Extract Tocopherol
question
lightbulb What are Ingredients Related to Skin Type?

Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.

We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.

muscle Pro Tip Alert!

A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.

One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!

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Ingredients Related to Skin Types

Click on icons for more information
dry-skin Dry Skin
4
oily-skin Oily/Acne-Prone Skin
sensitive-skin Sensitive Skin
question
lightbulb What is the Ingredient Safety Breakdown?

Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.

muscle Pro Tip Alert!

EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.

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Ingredient Safety Breakdown

EWG Health Ratings
Low risk
Medium risk
High risk
Unknown risk
38% 61%

Product ingredient list

Showing first 5 of 54 ingredients
EWG CIR Ingredient Name & Cosmetic Functions Notes
1 Unknown
Water
Solvent, Skin Conditioning
1 A
Squalane
Skin Conditioning, Emollient, Hair Conditioning, Refatting
Hydrating
1 B
Isodecyl Neopentanoate
Skin Conditioning, Emollient
2 A
Glycerin
Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant, Skin Conditioning
brightening Brightening
Promotes Wound Healing
Hydrating
1 A
Caprylic/Capric Triglyceride
Solvent, Skin Conditioning, Masking, Perfuming, Emollient
VIEW ALL INGREDIENTS