OS-01 EYE
OS-01 EYE
Product Description
Product overview
OneSkin OS-01 EYE is a lightweight, fragrance-free peptide eye cream built around the brand's proprietary OS-01 Peptide™ — a lab-developed "senescence-blocking" peptide designed to target skin aging at the cellular level. Formulated for the ultra-delicate skin around the eyes, it hydrates, firms, and softens the look of fine lines, crow's feet, and tired-looking eyes, with a creamy texture that absorbs fast and layers cleanly under makeup.
Senolytic OS-01 Peptide™
The headline active is a proprietary peptide developed to target senescent "zombie" cells that build up in skin and accelerate visible aging.
Texture & feel
SENSORYSenolytic OS-01 Peptide™
The headline active is a proprietary peptide developed to target senescent "zombie" cells that build up in skin and accelerate visible aging.
Clinically Tested Around the Eye
In a 12-week third-party study, 73% of participants saw improved firmness and skin barrier function rose by an average of +17%.
Layered Hydration
Sodium hyaluronate crosspolymer, glycerin, panthenol, squalane, and shea butter plump, soften, and comfort thin under-eye skin.
Antioxidant Defense
CoQ10 (ubiquinone), vitamin E, niacinamide, and coffee seed extract help defend against free-radical and environmental stress.
Safety & compatibility
SAFENo retinoids, salicylic acid, or hydroquinone. Built on peptides, niacinamide, and hyaluronic acid that are generally considered pregnancy-friendly. Always confirm with your OB/GYN.
Not malassezia-safe. Contains olive-derived emulsifiers, shea butter, jojoba oil, lecithin, and fatty-acid esters that can feed malassezia yeast.
Fragrance-free and dermatologist tested; marketed as safe for sensitive skin. A patch test is still wise because of the low-level alcohol.
Denatured alcohol sits low in the ingredient list, but a minority of users report slight dryness or stinging near the eyes.
Plays nicely with retinol, vitamin C, niacinamide, and AHA/BHA. Peptides are gentle and rarely conflict when used at separate steps.
No animal testing and no animal-derived ingredients, with a formula free from common allergens, parabens, silicones, and sulfates.
Ingredient breakdown
INGREDIENTSOS-01 Peptide™ (Proprietary) Highest in lineProven
OneSkin's signature senescence-blocking peptide and the reason this eye cream exists. It is designed to reduce the burden of senescent cells in skin, supporting collagen production and a "younger" cellular profile. OS-01 EYE carries the highest concentration of the peptide in the OneSkin range.
- Source: Lab studies showed OS-01 increased collagen by an average of +130% in human skin samples.
- Source: Peer-reviewed work (Zonari et al., Int. J. Cosmet. Sci., 2025) evaluated OS-01 specifically for periorbital skin aging.
Niacinamide ~2-4% (est.)Proven
Vitamin B3 is a true multitasker: it strengthens the skin barrier, helps fade dark spots and uneven tone, supports the look of firmness, and is well tolerated by most skin types, including sensitive and reactive skin.
- Source: Converted in skin to NAD, a coenzyme that supports repair, barrier function, and defense against UV and pollution.
- Source: Around 5% is the commonly studied level for brightening; lower levels still support barrier and tone.
Sodium Hyaluronate Crosspolymer HAProven
A modified, cross-linked form of hyaluronic acid that sits longer in the upper layers of skin than standard HA, delivering more sustained hydration and a plumping, smoothing effect on fine, crepey under-eye skin.
- Source: HA is a humectant that binds water in the skin; the crosspolymer structure extends its hydrating action.
- Source: 88% of participants reported improved hydration with OS-01 EYE in OneSkin's reported data.
Acetyl Hexapeptide-8 (Argireline) ~0.2-0.35%Promising
A popular "Botox-like" peptide that may relax the micro-movements that etch expression lines. Often used in the eye area to soften the look of crow's feet, and it may lend modest support to collagen.
- Source: Estimated at roughly 0.2-0.35% based on third-party ingredient analysis (placement in the INCI list).
- Source: Evidence is encouraging but less robust than for retinoids; results are subtle and build with use.
Gluconolactone (PHA) PHAPromising
A polyhydroxy acid that gently encourages surface cell turnover for smoother texture and brightness, but with far less irritation than AHAs — a sensible choice for the thin, reactive skin near the eyes.
- Source: PHAs have larger molecules than AHAs, so they exfoliate more gently and are better tolerated by sensitive skin.
- Source: A 2004 study found gluconolactone helped protect skin cells from UV damage and did not increase sun sensitivity.
40 ingredients
Water, Glycerin, Sorbitan Olivate, Squalane, Cetearyl Olivate, Butyrospermum Parkii Butter, Simmondsia Chinensis Seed Oil, Cystoseira Humilis Extract, Panthenol, Bentonite, Cetyl Palmitate, Sodium Hyaluronate Crosspolymer, Caprylhydroxamic Acid, Sorbitan Palmitate, Cellulose, Coffea Arabica Seedcake Extract, Allantoin, Fucus Vesiculosus Extract, Gluconolactone, Niacinamide, Sh-Polypeptide-121, Sisymbrium Irio Seed Oil, Tocopheryl Acetate, Sorbic Acid, Caprylic/Capric Triglyceride, Ubiquinone, Lecithin, Decapeptide-52, Sodium Chloride, Maltodextrin, Acetyl Hexapeptide-8, Moringa Oleifera Seed Extract, Glyceryl Caprylate, Caprylyl Glycol, Tetrasodium Glutamate Diacetate, Alcohol, Sodium Benzoate, Phenoxyethanol, Xanthan Gum, Pentapeptide-8.
Where it fits in your routine
ROUTINEApply OS-01 EYE after lightweight serums and before richer creams or facial oils. In the morning, always finish the surrounding skin with SPF.
How to use
HOW TO USEStart Clean
Cleanse and lightly pat dry. OneSkin suggests pairing with its PREP cleanser, but any gentle cleanser works.
Dispense One Pump
A single pump is enough for both eyes — a little goes a long way, which helps stretch the 20 mL bottle.
Tap, Don't Tug
Gently tap in a semi-circle around each eye, from the under-eye to the eyelid and beneath the brow bone.
AM and/or PM
Use 1-2 times daily, then follow with your moisturizer. Consistency over months is where the peptide pays off.
Who is it for?
WHOPerfect for you if:
- You want a peptide-forward, fragrance-free eye cream
- You're focused on long-term, preventative anti-aging
- You have sensitive or reactive skin and dislike retinol stinging
- You want firming plus hydration in one lightweight step
- You value brands with published clinical research
Consider alternatives if:
- You're managing fungal acne (malassezia) around the eyes
- You want a drugstore price point
- You need instant dark-circle color correction (caffeine / pigment)
- You avoid any alcohol in your formulas
- You expect overnight, dramatic results
Skin type compatibility
SKIN TYPESThe core use case — peptide and collagen support targeting fine lines, crepiness, and loss of firmness.
Fragrance-free and dermatologist tested. Patch test first due to the small amount of alcohol.
Shea, squalane, and HA crosspolymer deliver comforting hydration; layer a richer cream on top in winter.
Lightweight and fast-absorbing around the eye without feeling heavy or greasy.
Non-comedogenic and lightweight, but it is not fungal-acne safe — skip if malassezia is a concern.
Results timeline
6 MONTHS+Hydration & Brightness
Early users most often notice a brighter, more rested look and smoother, better-hydrated under-eye skin.
88% reported improved hydrationSofter Fine Lines
Crow's feet and fine expression lines begin to look softer as peptides and PHA support texture.
Many noticed smoother textureFirmer, Stronger Skin
In a 12-week clinical study, firmness improved by an average of +10.19% and barrier function rose by +17%.
73% saw improved firmnessLong-Term Renewal
The longevity payoff: continued peptide use supports collagen and the cellular health of delicate eye-area skin.
Best with consistent daily useRatings by platform
1K+ REVIEWSPros & cons
BALANCEDPraised
- Backed by peer-reviewed clinical research
- Silky, lightweight, fast-absorbing texture
- Fragrance-free and sensitive-skin friendly
- Visible firming, hydration, and brightening over time
- Refillable, eco-conscious packaging
Criticized
- Premium price (~$109 for 20 mL)
- Not fungal-acne (malassezia) safe
- Contains alcohol — mild dryness for some
- Dark circles improve slowly, if at all
- Peptides require disciplined, long-term use
Budget-friendly alternatives (dupes)
DUPES
Stacks several proven peptide technologies (Matrixyl synthe'6, Eyeseryl, Argireline-type) plus niacinamide for a fraction of the price. Lacks the senolytic OS-01 peptide and the longevity research, and the texture is a watery serum rather than a cream.
Caffeine-focused for puffiness and dark circles with light hydration. Great value for tired eyes, but it isn't built around collagen-supporting peptides or aging at the cellular level.
Ceramides, niacinamide, and hyaluronic acid for barrier repair and basic hydration. A solid, fragrance-free everyday option, but no peptide actives and no firming or anti-senescence claims.
Comparison with competitors
SIDE-BY-SIDE
Storage & shelf life
6 MONTHSUse within about 6 months of opening for peak peptide potency (unopened shelf life is up to 24 months).
Store at room temperature, away from direct sunlight and heat. Peptides are light- and heat-sensitive.
Airless pump with a refillable outer housing — one pump dispenses the right dose for both eyes.
Yes — the 20 mL size is TSA-friendly, and a 7 mL travel size is also available.
Frequently asked questions
FAQIt's generally considered low-risk. The formula contains no retinoids, salicylic acid, or hydroquinone — the ingredients most often flagged during pregnancy. Its core actives (peptides, niacinamide, hyaluronic acid, panthenol) are widely regarded as pregnancy-friendly. That said, ingredient tolerance is individual, so confirm with your OB/GYN or midwife before adding any new product.
No. It contains several ingredients that can feed malassezia yeast, including sorbitan olivate and cetearyl olivate (olive-derived), shea butter, jojoba seed oil, cetyl palmitate, lecithin, and caprylic/capric triglyceride. If you're actively managing fungal acne around the eyes, this is not the right pick.
Yes. Peptides are gentle and don't typically conflict with other actives. Many people use a retinoid or vitamin C elsewhere in the routine and apply OS-01 EYE around the eyes at a separate step. If your skin is sensitive, introduce one new active at a time and watch for irritation, especially given the cream's small alcohol content.
It suits most skin types and shines for mature, dry, and sensitive skin focused on firmness, hydration, and fine lines. It's also fine for combination and oily skin thanks to its lightweight feel. The main exception is anyone managing fungal acne, who should look elsewhere.
Hydration and a brighter, more rested look often show within the first 1-2 weeks. Smoother fine lines tend to appear around 4 weeks, while firmness and barrier improvements were measured at the 12-week mark in clinical testing. Dark circles are the slowest to change. Like all peptide products, it rewards consistent daily use.
After cleansing and any lightweight serums, and before heavier creams or facial oils. Gently tap one pump in a semi-circle around each eye, from the under-eye to the eyelid and beneath the brow bone. Use morning and/or night, and always finish your AM routine with SPF.
It's marketed as non-comedogenic and earns a low comedogenic rating (around 2/5). It does contain richer emollients like shea butter and jojoba oil, so very congestion-prone users should apply it precisely around the orbital bone rather than across the whole face.
For best potency, use it within about 6 months of opening, since peptides degrade with exposure to light and heat. Unopened, the product has a shelf life of up to 24 months. Keep it at room temperature, away from direct sun — a closed drawer is ideal.
Verdict: OneSkin OS-01 EYE is one of the most science-forward eye creams on the market, built around a peer-reviewed senolytic peptide that targets aging at the cellular level rather than just smoothing the surface. Expect a lightweight, fragrance-free cream that hydrates immediately and delivers firmer, smoother-looking eyes with patient daily use — backed by 12-week clinical data on firmness and barrier function. The trade-offs are real: it's expensive for 20 mL, it's not fungal-acne safe, and it won't fix structural dark circles. But for sensitive or mature skin focused on long-term prevention, it's a standout. Budget shoppers can get most of the peptide benefit from The Ordinary Multi-Peptide Eye Serum for a fraction of the price.
Product Overview
What are Quick Product Notes?
Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.
Pro Tip Alert!
Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.
Quick Product Notes
Paraben-Free
Paraben-Free
Understanding Parabens
Parabens are a large group of preservatives which are used to prevent bacteria growing in cosmetic formulations. There has been some healthy controversy surrounding them due to a few studies finding paraben presence in breast tumours and breast tissue. However, the majority of the scientific community have deemed these findings non-conclusive due to the limitations of these studies. There's still a lot of support for avoiding parabens following the better safe than sorry route. If you do we completely support you! If you are concerned about the health safety of parabens, then feel free to avoid them by looking out for the Paraben-Free icon. If not, don't worry about it - they do have had one of the longest safety records as preservatives!
Which Ingredients are classified as Paraben?
A product will be paraben-free if it does not contain any of the following parabens:
- Sodium Isobutylparaben
- Sodium Ethylparaben
- Sodium Butylparaben
- Propylparaben
- Isopropylparaben
- Isobutylparaben
- Sodium Propylparaben
- Butylparaben
- Ethylparaben
- Sodium Methylparaben
- Methylparaben
Sulfate-Free
Sulfate-Free
Understanding Sulfates
Sulfates are a large group of ingredients which act as cleansing agents in Cosmetics. They help loosen up the dirt and grime from your skin and hair to allow for water to wash it away with ease. However some sulfates are so good at their job, they can wash off your skin’s own natural oils that keep it moisturised and protected which can lead to dryness and irritation. Most people will find no issues with sulfate, however if you find your skin doesn't like sulfates then free feel to avoid them by looking out for the sulfate-free icon on Skincarisma.
Which ingredients are classified as sulfates?
We've taken the Sulfates which are considered more harsh for our Sulfate-Free status. A product will be Sulfate-Free if it does not contain any of the following Sulfates:
- TEA-Dodecylbenzenesulfonate
- Ammonium Laureth Sulfate
- Sodium Lauryl Sulfate
- PEG-15 Cocamine
- Sodium Laureth Sulfate
- Sodium Cocoyl Sarcosinate
- Sodium C14-16 Olefin Sulfonate
- Dioctyl Sodium Sulfosuccinate
- Ammonium Xylenesulfonate
- Ammonium Lauryl Sulfate
- Sodium Xylenesulfonate
- Sodium Myreth Sulfate
- Sodium Lauryl Sulfoacetate
Alcohol-Free
Alcohol-Free
Understanding Simple Alcohols
Alcohol ingredients are widely used in cosmetics and come in different types. For the most part alcohols are not problematic at all. However one type of alcohols, simple alcohols can be quite drying to the skin because it evaporates very quickly. This can cause irritation which can also lead to other skin complications. These alcohols should never be used alone on your skin, but combined with other cosmetic ingredients, they are normally without issue. However, for some people with sensitive and easily irritable skin, avoiding products with these simple alcohols may be beneficial. If you find your skin doesn't like these simple alcohols, then free feel to avoid them by looking out for the Alcohol-Free icon.
Which Ingredients are classified as Alcohol?
A product will be alcohol-free if it does not contain any of the following alcohol ingredients:
- SD Alcohol
- Alcohol Denat
- Isopropyl Alcohol
- Alcohol
Silicone-Free
Silicone-Free
Understanding Silicones
If you've ever used a skincare, makeup or beauty product that's made your skin look and feel smoother tempoarily - it's likely contained Silicone. They are a popular class of ingredients found in cosmetics due to their smooth, soft, easy-to-spread and smooth properties that help creates an artificial layer/barrier on top of skin or hair (commonly found in conditioners).
For the same reasons they are popularly used, they are also commonly avoided. Anecdotally, many individuals have reported that Silicones cause/excerbate breakouts, irritation, cause a feeling of skin being unable to breathe, cause clumping of cosmetic products and find it difficult to wash off. As a result, those who find them problematic are avoiding them and increasingly, cosmetic companies are avoiding them as well.
If you have had bad experiences with Silicones in the past, or suspect they are problematic then look out for the tick on the Silicone-free label.
Disclaimer
The Silicone-free label only includes the most common Silicone ingredients that have indentified been reported by individuals that could potentially cause issues.
These include: Amodimethicone, Behenoxy Dimethicone, Bis-Aminopropyl Dimethicone, Cetearyl Methicone, Cetyl Dimethicone, Cyclomethicone, Cyclopentasiloxane, Dimethicone, Dimethicone Copolyol, Dimethiconol, Methicone, Phenyl Trimethicone, Phenyl Trimethicone, Stearoxy Dimethicone, Stearyl Dimethicone, Trimethylsilylamodimethicone.
Note, that this does not include all ingredients part of the Silicone class of ingredients.
EU Allergen-Free
EU Allergen-Free
Understanding the Identified Contact Allergens
The EU's Scientific Committee on Consumer Safety (SCCS) has identified and established 26 cosmetic ingredients that are likely contact allergens (potential to cause skin allergies) as demonstrated in clinical or epidemiological studies. The EU's SCCS have recommend cosmetic companies to disclose them on the labels if used and in cases where the concentration exceeds 0.001% in leave-on products and 0.01% in rinse-off products, then they must be labelled.
Look out for the tick on the EU-Allergen free label to know your cosmetic is free from any of the 26 identified cosmetic ingredients.
For more information regarding the EU's Scientific Committee on Consumer Safety, please visit their official website.
Disclaimer
The EU Allergen Free label is for the 26 ingredients identified by the EU SCCS and products will be only flagged if a suspected ingredient is on it's ingredient list. It is possible for cosmetics to contain one of the suspect ingredients without it appearing on the ingredient list due to it not reaching the concentration threshold to disclose it and cosmetic manufacturers choice to not disclose it.
Also note, the EU Allergen Free label is not personalized for your own allergies you may have and it does not constitute as medical advice. For your specific case, always consult your medical professiona such as dermatologist, physician, pharmacist, or health care provider - please read our medical disclaimer for more information.
Fungal Acne (Molassezia) Safe
Fungal Acne (Molassezia) Safe
Understanding Fungal Acne (Pityrosporum Folliculitis/Malassezia Folliculitis)
Pityrosporum Folliculitis/Malassezia folliculitis or simply known as Fungal Acne is a persistent acne-like condition that commonly responds poorly to traditional acne-treating methods. Unlike most cases of Acne where bacteria is the culprit, Fungi is the culprit of Fungal Acne (Hence the name!). There are certain classes & groups of ingredients that have been shown to promote and feed the growth of the Fungal Acne, Fungi such as fatty acids, oils, esters, polysorbates and fermented ingredients.
For more information regarding Fungal Acne, please visit Simple Skincare Science (f.c) - #3 of our Recommend Skincare Resources for an amazing comprehensive guide!
Please Read: How to use the Fungal Acne (Malassezia) Label
At SkinCarisma, we've done our best to identify as many ingredients as possible but note the fungal-free label may not be 100% accurate due to the complexconditions and combination of ingredients that malezzeria can thrive on.
Additionally, products that may contain ingredients that have shown to feed Malassezia may not neccessarily exacerbate the condition due to concentration of ingredient used in the product, this information is simply not available on the products.
As a result, please note this is only an experimental label that can be best used to possible identify problematic products you have used in the past. It is in no way a perfect identifier nor a predictor in whether or not it will exacerbate or cause fungal acne. It will continue to be worked on as more information and research comes to light.
If you find any ingredients you believe should be included, please email us at snails@skincarisma.com.
Disclaimer
Due to the lack of substantial research into this area it is very likely there are other ingredients and class/groups of ingredients that could feed Fungal Acne which have not been indentified.
The Fungal-Safe label does not constitute as medical advice. For your specific case, always consult your medical professiona such as dermatologist, physician, pharmacist, or health care provider - please read our medical disclaimer for more information.
What are Notable Effects & Ingredients?
Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging «promises» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.
We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.
Pro Tip Alert!
Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.
Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you
Notable Effects & Ingredients
Anti-Aging from 4 ingredient(s):
Brightening from 2 ingredient(s):
Promotes Wound Healing from 5 ingredient(s):
Ache-fighting from 1 ingredient(s):
What are Ingredients Related to Skin Type?
Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.
We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.
Pro Tip Alert!
A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.
One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!
Ingredients Related to Skin Types
Dry Skin
Oily/Acne-Prone Skin
Sensitive Skin
What is the Ingredient Safety Breakdown?
Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.
Pro Tip Alert!
EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.
Ingredient Safety Breakdown
Product ingredient list
| EWG | CIR | Ingredient Name & Cosmetic Functions | Notes |
|---|---|---|---|
| 1 |
Water
Solvent, Skin Conditioning
|
|
|
| 2 |
Glycerin
Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant, Skin Conditioning
|
Brightening
Promotes Wound Healing
Hydrating
|
|
| 1 |
Sorbitan Olivate
Surfactant, Emulsifying
|
|
|
| 1 |
Squalane
Skin Conditioning, Emollient, Hair Conditioning, Refatting
|
Hydrating
|
|
| 1 |
Cetearyl Olivate
Hair Conditioning
|
|