PDRN Hyaluronic Acid 100 Moisturizing Cream
PDRN Hyaluronic Acid 100 Moisturizing Cream
Product Description
Product overview
A lightweight, fast-absorbing moisturizing cream enriched with low-molecular PDRN (salmon DNA), 10 types of hyaluronic acid, and hydrolyzed collagen. Clinically tested to support collagen improvement by up to 68.3% while delivering 100-hour deep hydration for plump, glass-like skin.
Low-Molecular PDRN Technology
Salmon DNA-derived ingredient with enhanced absorption that stimulates cell regeneration and supports collagen production from within.
Texture & feel
SENSORYLow-Molecular PDRN Technology
Salmon DNA-derived ingredient with enhanced absorption that stimulates cell regeneration and supports collagen production from within.
10 Types of Hyaluronic Acid
Multi-molecular weight HA complex provides hydration at every skin layer, from surface to deep dermis, for 100-hour moisture retention.
Collagen Boosting Complex
Clinically tested to improve collagen by 68.3%, combining hydrolyzed collagen with PDRN for firmer, more elastic skin.
Centella Asiatica Extract
Soothing botanical with madecassoside and asiaticoside to calm irritation and support skin barrier repair.
Safety & compatibility
SAFEFree from retinoids, salicylic acid, hydroquinone, and chemical sunscreens. All ANUA products are EWG Green grade certified. Consult your physician if you have concerns.
Contains squalane which may trigger fungal acne depending on the source (olive vs. sugarcane derived). Contact brand for squalane source if concerned.
Fragrance-free, colorant-free formula with soothing Centella Asiatica. Dermatologist tested and hypoallergenic.
PDRN is derived from salmon sperm cells. Not suitable for vegans or those with fish allergies.
Ingredient breakdown
INGREDIENTSPDRN (Sodium DNA)Promising
Polydeoxyribonucleotide derived from salmon DNA. This innovative ingredient activates adenosine A2A receptors to stimulate fibroblast activity, promote collagen synthesis, and support tissue repair at the cellular level.
- Research: Studies show PDRN promotes angiogenesis, cellular activity, and collagen synthesis
- Mechanism: Activates adenosine receptors and supports the skin's "salvage pathway" for DNA repair
- Clinical Use: Originally used in wound healing and tissue regeneration medicine
10 Types of Hyaluronic AcidProven
Multi-molecular weight complex including Sodium Hyaluronate, Hydrolyzed HA, Potassium Hyaluronate, Hydroxypropyltrimonium Hyaluronate, and more. Provides layered hydration from surface to deep dermis.
- Hydration: HA can hold up to 1,000x its weight in water
- Low-MW HA: Penetrates deeper for internal hydration and elasticity
- High-MW HA: Forms protective film for instant surface hydration
Hydrolyzed CollagenProven
Low-molecular weight collagen peptides that support skin structure, firmness, and elasticity. Works synergistically with PDRN for enhanced anti-aging benefits.
- Clinical Result: 68.3% improvement in collagen support (brand claim)
- Plumping: 10.79% improvement in moisture plumping effect
- Structure: Strengthens skin's structural matrix for bounce and firmness
Niacinamide Top 10Proven
Vitamin B3 derivative that brightens skin, minimizes pores, strengthens the skin barrier, and regulates sebum production.
- Brightening: Inhibits melanin transfer for even skin tone
- Barrier: Increases ceramide production to strengthen skin barrier
- Anti-aging: Reduces fine lines and improves skin elasticity
SqualaneProven
Lightweight, non-greasy emollient that mimics skin's natural sebum. Provides moisture without clogging pores and helps other ingredients penetrate better.
- Compatibility: Biocompatible with human skin sebum
- Absorption: Quickly absorbs without greasy residue
- Barrier: Locks in moisture and protects skin barrier
48 ingredients
Water, Squalane, Glycerin, Niacinamide, Pentylene Glycol, 1,2-Hexanediol, Sodium DNA, Hydrolyzed Collagen, Sodium Hyaluronate, Melia Azadirachta Leaf Extract, Hydrolyzed Hyaluronic Acid, Melia Azadirachta Flower Extract, Coccinia Indica Fruit Extract, Hyaluronic Acid, Aloe Barbadensis Flower Extract, Solanum Melongena (Eggplant) Fruit Extract, Ocimum Sanctum Leaf Extract, Corallina Officinalis Extract, Curcuma Longa (Turmeric) Root Extract, Centella Asiatica Leaf Extract, Diphenylsiloxy Phenyl Trimethicone, PCA Dimethicone, Butylene Glycol, Propanediol, Ammonium Acryloyldimethyltaurate/VP Copolymer, Diglycerin, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, C12-20 Alkyl Glucoside, Methylpropanediol, Ethylhexylglycerin, Adenosine, Sodium Phytate, Aminomethyl Propanediol, PVM/MA Copolymer, Madecassoside, C12-13 Alketh-9, Dimethylsilanol Hyaluronate, Hydrolyzed Sodium Hyaluronate, Asiaticoside, Potassium Hyaluronate, Hydroxypropyltrimonium Hyaluronate, Sodium Hyaluronate Crosspolymer, Sodium Acetylated Hyaluronate
Where it fits in your routine
ROUTINEApply as the final step of your skincare routine. Use morning and night. Always follow with SPF 30+ during daytime.
How to use
HOW TO USEDispense Product
Use the dropper-type tip to dispense a pea-sized amount onto your fingertips for hygienic application.
Apply to Face
Dot the cream across your forehead, cheeks, nose, and chin. Gently spread evenly across your entire face.
Pat for Absorption
Use gentle patting motions to help the cream absorb fully. The formula melts into skin without stickiness.
Follow with SPF (AM)
In the morning, always finish with a broad-spectrum sunscreen SPF 30 or higher to protect your skin.
Who is it for?
WHOPerfect for you if:
- You want glass skin with a dewy, plump finish
- Your skin is dehydrated, dull, or showing early signs of aging
- You need barrier repair after harsh treatments or breakouts
- You prefer lightweight, non-sticky moisturizers
- You want K-beauty innovation with clinical backing
- You need a fragrance-free option for sensitive skin
Consider alternatives if:
- You follow a strictly vegan skincare routine (contains salmon DNA)
- You have a fish allergy
- You need very rich, heavy moisturization for extremely dry skin
- You have active fungal acne and are concerned about squalane
- You prefer matte-finish moisturizers
Skin type compatibility
SKIN TYPESLightweight gel-cream texture absorbs quickly without adding shine. Non-greasy, non-sticky finish perfect for oily skin.
Provides excellent hydration with 10 types of HA. Very dry skin may benefit from layering or adding a heavier occlusive on top.
Ideal balance of hydration without heaviness. Works well across different face zones without causing oiliness in T-zone.
Fragrance-free, colorant-free with soothing Centella Asiatica. EWG Green grade certified and dermatologist tested.
Low comedogenic rating (1/5). Great for post-acne inflammation. Those with fungal acne should check squalane source first.
Results timeline
WEEK 4-8Instant Hydration & Plumping
Skin feels immediately hydrated, plump, and refreshed with a dewy glass-skin finish. No stickiness or residue.
95% noticed instant hydrationImproved Skin Texture
Skin begins to feel smoother and softer. Barrier repair and texture improvements become noticeable with consistent use.
80% noticed smoother skinEnhanced Radiance & Firmness
Visible improvement in skin radiance and bounce. PDRN and collagen work together to improve skin elasticity and glow.
70% noticed improved firmnessReduced Fine Lines & Lasting Results
With continued use, expect visible reduction in fine lines, improved collagen production, and overall healthier-looking skin.
65% noticed fine line reductionRatings by platform
530+ REVIEWSPros & cons
BALANCEDPraised
- Lightweight, fast-absorbing, non-sticky formula
- Delivers instant plumping and glass-skin effect
- Clinically tested with impressive results
- Fragrance-free and EWG Green certified
- Works beautifully under makeup without pilling
- Innovative PDRN technology backed by science
- 10 types of hyaluronic acid for multi-layer hydration
- Suitable for sensitive skin
Criticized
- Not vegan (contains salmon DNA)
- 60ml size may not last long for daily AM/PM use
- Higher price point than basic moisturizers
- Squalane source not specified (fungal acne concern)
- May not be rich enough for extremely dry skin
- Emerald tint may initially look unusual
Budget-friendly alternatives (dupes)
DUPES
Larger 100ml size with 5 types of HA. No PDRN or collagen but excellent hydration with panthenol and allantoin. Vegan-friendly option.
Uses snail mucin instead of PDRN for regeneration. Similar hydrating/plumping effects. Lightweight texture but different active mechanism.
Basic hydration with HA and amino acids. No PDRN, collagen, or advanced technology. Good entry-level option but less sophisticated formula.
Comparison with competitors
SIDE-BY-SIDEANUA PDRN HA 100 Cream
Storage & shelf life
12 MONTHS12 months after opening
Store in a cool, dry place away from direct sunlight. Keep out of reach of children.
Dropper-type dispenser tip for hygienic application. Emerald-tinted cream in opaque container.
Yes, 60ml is under the 100ml TSA liquid limit for carry-on luggage.
Frequently asked questions
FAQYes, this cream is considered pregnancy and breastfeeding safe. It contains no retinoids, salicylic acid, hydroquinone, or chemical sunscreens. All ANUA products are EWG Green grade certified, meaning they don't contain harmful ingredients. However, pregnancy can cause hormonal changes that may trigger new skin reactions, so patch testing is recommended. Always consult your physician if you have specific concerns.
Caution is advised. The formula contains squalane, which may or may not be fungal acne safe depending on its source. Olive-derived squalane can contain impurities like fatty acids, while sugarcane-derived squalane is generally safer for malassezia concerns. The brand has not disclosed the squalane source. If you have fungal acne, contact ANUA directly to confirm the source before purchasing.
Yes, this moisturizer is compatible with most active ingredients. The formula is gentle, fragrance-free, and contains soothing ingredients like Centella Asiatica. It works well as the moisturizing step after applying actives. For best results: use retinol or exfoliating acids first, wait for absorption, then apply this cream to lock in moisture and soothe the skin. Vitamin C can be used in AM with this cream followed by sunscreen.
This cream is excellent for all skin types, particularly: combination skin (balances hydration without heaviness), oily skin (lightweight, non-greasy formula), sensitive skin (fragrance-free, EWG certified), and normal skin seeking anti-aging benefits. It's also good for dry skin, though those with very dry skin may want to layer it with a heavier occlusive or sleeping mask.
Results vary by individual, but typical timeline: Immediate – instant hydration, plumping, and dewy finish. Week 1-2 – smoother skin texture and improved barrier function. Week 2-4 – enhanced radiance, firmness, and bounce. Week 4-8 – visible reduction in fine lines with continued collagen support. Clinical testing showed 68.3% collagen improvement and 10.79% moisture plumping effect.
Apply as the final step of your skincare routine (before sunscreen in AM). The recommended order is: 1) Cleanser, 2) Toner, 3) Serum/Essence (like ANUA PDRN Serum), 4) This Cream, 5) Sunscreen (morning only). Use both AM and PM. The dropper-type dispenser allows hygienic application. Pat gently until absorbed.
No, this cream has a low comedogenic rating of 1/5. The formula is lightweight, non-greasy, and absorbs quickly without leaving residue. It doesn't contain heavy oils, parabens, or pore-clogging ingredients. The non-sticky formula is suitable for acne-prone skin and works well under makeup without causing pilling or breakouts.
The Period After Opening (PAO) is 12 months. Store in a cool, dry place away from direct sunlight. The 60ml size with daily AM/PM use typically lasts 2-3 months depending on how much product you apply. The dropper-type dispenser helps maintain hygiene and prevents contamination.
Verdict: The ANUA PDRN Hyaluronic Acid 100 Moisturizing Cream delivers on its promise of glass-skin hydration with innovative K-beauty technology. The combination of low-molecular PDRN, 10 types of hyaluronic acid, and hydrolyzed collagen creates a powerful anti-aging moisturizer that's lightweight yet deeply effective. Clinical testing backs up the impressive collagen and hydration claims. While the price point is higher than basic moisturizers and the 60ml size is modest, the quality ingredients and results justify the investment for those seeking serious skincare benefits. Not suitable for vegans due to salmon DNA, but excellent for anyone wanting plump, dewy, youthful-looking skin.
Product Overview
What are Quick Product Notes?
Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.
Pro Tip Alert!
Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.
Quick Product Notes
Paraben-Free
Paraben-Free
Understanding Parabens
Parabens are a large group of preservatives which are used to prevent bacteria growing in cosmetic formulations. There has been some healthy controversy surrounding them due to a few studies finding paraben presence in breast tumours and breast tissue. However, the majority of the scientific community have deemed these findings non-conclusive due to the limitations of these studies. There's still a lot of support for avoiding parabens following the better safe than sorry route. If you do we completely support you! If you are concerned about the health safety of parabens, then feel free to avoid them by looking out for the Paraben-Free icon. If not, don't worry about it - they do have had one of the longest safety records as preservatives!
Which Ingredients are classified as Paraben?
A product will be paraben-free if it does not contain any of the following parabens:
- Sodium Isobutylparaben
- Sodium Ethylparaben
- Sodium Butylparaben
- Propylparaben
- Isopropylparaben
- Isobutylparaben
- Sodium Propylparaben
- Butylparaben
- Ethylparaben
- Sodium Methylparaben
- Methylparaben
Sulfate-Free
Sulfate-Free
Understanding Sulfates
Sulfates are a large group of ingredients which act as cleansing agents in Cosmetics. They help loosen up the dirt and grime from your skin and hair to allow for water to wash it away with ease. However some sulfates are so good at their job, they can wash off your skin’s own natural oils that keep it moisturised and protected which can lead to dryness and irritation. Most people will find no issues with sulfate, however if you find your skin doesn't like sulfates then free feel to avoid them by looking out for the sulfate-free icon on Skincarisma.
Which ingredients are classified as sulfates?
We've taken the Sulfates which are considered more harsh for our Sulfate-Free status. A product will be Sulfate-Free if it does not contain any of the following Sulfates:
- TEA-Dodecylbenzenesulfonate
- Ammonium Laureth Sulfate
- Sodium Lauryl Sulfate
- PEG-15 Cocamine
- Sodium Laureth Sulfate
- Sodium Cocoyl Sarcosinate
- Sodium C14-16 Olefin Sulfonate
- Dioctyl Sodium Sulfosuccinate
- Ammonium Xylenesulfonate
- Ammonium Lauryl Sulfate
- Sodium Xylenesulfonate
- Sodium Myreth Sulfate
- Sodium Lauryl Sulfoacetate
Alcohol-Free
Alcohol-Free
Understanding Simple Alcohols
Alcohol ingredients are widely used in cosmetics and come in different types. For the most part alcohols are not problematic at all. However one type of alcohols, simple alcohols can be quite drying to the skin because it evaporates very quickly. This can cause irritation which can also lead to other skin complications. These alcohols should never be used alone on your skin, but combined with other cosmetic ingredients, they are normally without issue. However, for some people with sensitive and easily irritable skin, avoiding products with these simple alcohols may be beneficial. If you find your skin doesn't like these simple alcohols, then free feel to avoid them by looking out for the Alcohol-Free icon.
Which Ingredients are classified as Alcohol?
A product will be alcohol-free if it does not contain any of the following alcohol ingredients:
- SD Alcohol
- Alcohol Denat
- Isopropyl Alcohol
- Alcohol
Silicone-Free
Silicone-Free
Understanding Silicones
If you've ever used a skincare, makeup or beauty product that's made your skin look and feel smoother tempoarily - it's likely contained Silicone. They are a popular class of ingredients found in cosmetics due to their smooth, soft, easy-to-spread and smooth properties that help creates an artificial layer/barrier on top of skin or hair (commonly found in conditioners).
For the same reasons they are popularly used, they are also commonly avoided. Anecdotally, many individuals have reported that Silicones cause/excerbate breakouts, irritation, cause a feeling of skin being unable to breathe, cause clumping of cosmetic products and find it difficult to wash off. As a result, those who find them problematic are avoiding them and increasingly, cosmetic companies are avoiding them as well.
If you have had bad experiences with Silicones in the past, or suspect they are problematic then look out for the tick on the Silicone-free label.
Disclaimer
The Silicone-free label only includes the most common Silicone ingredients that have indentified been reported by individuals that could potentially cause issues.
These include: Amodimethicone, Behenoxy Dimethicone, Bis-Aminopropyl Dimethicone, Cetearyl Methicone, Cetyl Dimethicone, Cyclomethicone, Cyclopentasiloxane, Dimethicone, Dimethicone Copolyol, Dimethiconol, Methicone, Phenyl Trimethicone, Phenyl Trimethicone, Stearoxy Dimethicone, Stearyl Dimethicone, Trimethylsilylamodimethicone.
Note, that this does not include all ingredients part of the Silicone class of ingredients.
EU Allergen-Free
EU Allergen-Free
Understanding the Identified Contact Allergens
The EU's Scientific Committee on Consumer Safety (SCCS) has identified and established 26 cosmetic ingredients that are likely contact allergens (potential to cause skin allergies) as demonstrated in clinical or epidemiological studies. The EU's SCCS have recommend cosmetic companies to disclose them on the labels if used and in cases where the concentration exceeds 0.001% in leave-on products and 0.01% in rinse-off products, then they must be labelled.
Look out for the tick on the EU-Allergen free label to know your cosmetic is free from any of the 26 identified cosmetic ingredients.
For more information regarding the EU's Scientific Committee on Consumer Safety, please visit their official website.
Disclaimer
The EU Allergen Free label is for the 26 ingredients identified by the EU SCCS and products will be only flagged if a suspected ingredient is on it's ingredient list. It is possible for cosmetics to contain one of the suspect ingredients without it appearing on the ingredient list due to it not reaching the concentration threshold to disclose it and cosmetic manufacturers choice to not disclose it.
Also note, the EU Allergen Free label is not personalized for your own allergies you may have and it does not constitute as medical advice. For your specific case, always consult your medical professiona such as dermatologist, physician, pharmacist, or health care provider - please read our medical disclaimer for more information.
Fungal Acne (Molassezia) Safe
Fungal Acne (Molassezia) Safe
Understanding Fungal Acne (Pityrosporum Folliculitis/Malassezia Folliculitis)
Pityrosporum Folliculitis/Malassezia folliculitis or simply known as Fungal Acne is a persistent acne-like condition that commonly responds poorly to traditional acne-treating methods. Unlike most cases of Acne where bacteria is the culprit, Fungi is the culprit of Fungal Acne (Hence the name!). There are certain classes & groups of ingredients that have been shown to promote and feed the growth of the Fungal Acne, Fungi such as fatty acids, oils, esters, polysorbates and fermented ingredients.
For more information regarding Fungal Acne, please visit Simple Skincare Science (f.c) - #3 of our Recommend Skincare Resources for an amazing comprehensive guide!
Please Read: How to use the Fungal Acne (Malassezia) Label
At SkinCarisma, we've done our best to identify as many ingredients as possible but note the fungal-free label may not be 100% accurate due to the complexconditions and combination of ingredients that malezzeria can thrive on.
Additionally, products that may contain ingredients that have shown to feed Malassezia may not neccessarily exacerbate the condition due to concentration of ingredient used in the product, this information is simply not available on the products.
As a result, please note this is only an experimental label that can be best used to possible identify problematic products you have used in the past. It is in no way a perfect identifier nor a predictor in whether or not it will exacerbate or cause fungal acne. It will continue to be worked on as more information and research comes to light.
If you find any ingredients you believe should be included, please email us at snails@skincarisma.com.
Disclaimer
Due to the lack of substantial research into this area it is very likely there are other ingredients and class/groups of ingredients that could feed Fungal Acne which have not been indentified.
The Fungal-Safe label does not constitute as medical advice. For your specific case, always consult your medical professiona such as dermatologist, physician, pharmacist, or health care provider - please read our medical disclaimer for more information.
What are Notable Effects & Ingredients?
Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging «promises» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.
We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.
Pro Tip Alert!
Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.
Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you
Notable Effects & Ingredients
What are Ingredients Related to Skin Type?
Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.
We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.
Pro Tip Alert!
A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.
One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!
Ingredients Related to Skin Types
Dry Skin
Oily/Acne-Prone Skin
Sensitive Skin
What is the Ingredient Safety Breakdown?
Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.
Pro Tip Alert!
EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.