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PDRN Hyaluronic Capsule 100 Serum

PDRN Hyaluronic Capsule 100 Serum

Product Description

Product overview

Made in South Korea K-BEAUTY

A deeply hydrating emerald-toned serum featuring 100ppm PDRN (salmon DNA), 11 types of hyaluronic acid, and hydrolyzed collagen. This 2024 Glow Pick Award winner uses Smart Capsule Technology to deliver intense moisture, support skin regeneration, and create that coveted Korean glass skin glow.

Fragrance-Free 2024 Glow Pick Award 11 Types of Hyaluronic Acid Smart Capsule Technology Dermatologist Tested Low Irritation Tested
Pregnancy
Yes
Fungal Acne
No
Comedogenic
1/5
Size
30ml
PDRN
100ppm
HA Types
11 Types
Skin Type
All Types
Use
AM/PM
Why it's different

PDRN Technology

100ppm salmon DNA-derived PDRN supports skin cell regeneration and promotes collagen synthesis for firmer, more elastic skin.

01

Texture & feel

SENSORY
Consistency
Watery-Oily
Scent
Fragrance-Free
Absorption
Fast (15-30s)
Finish
Dewy Glass Skin

PDRN Technology

100ppm salmon DNA-derived PDRN supports skin cell regeneration and promotes collagen synthesis for firmer, more elastic skin.

Multi-Weight Hyaluronic Acid

11 types of HA at varying molecular weights penetrate different skin layers for comprehensive, long-lasting hydration.

Smart Capsule Technology

Ultra-low-molecular liposome encapsulation ensures active ingredients reach deeper skin layers for maximum efficacy.

Triple Complex Formula

PDRN + Hyaluronic Acid + Collagen work synergistically to hydrate, plump, and strengthen the skin barrier.

02

Safety & compatibility

SAFE
Pregnancy & Breastfeeding Safe

Free from retinoids, salicylic acid, and other pregnancy-concerning ingredients. Contains gentle, hydrating actives safe for expecting mothers.

Not Fungal Acne Safe

Contains Glyceryl Oleate and Polyglyceryl-6 Laurate which may feed malassezia yeast. Those prone to fungal acne should avoid.

Low Irritation Tested

Clinically tested for low irritation. Fragrance-free formula suitable for sensitive skin types. Patch test recommended.

Fish Allergy Warning

PDRN is derived from salmon DNA. Those with severe fish or seafood allergies should consult a dermatologist before use.

03

Ingredient breakdown

INGREDIENTS

PDRN (Sodium DNA) 100ppmPromising

Polydeoxyribonucleotide derived from salmon DNA. Supports skin cell regeneration, collagen production, and wound healing. Popular in Korean aesthetic treatments.

  • Function: Activates A2A adenosine receptors to stimulate tissue repair and reduce inflammation
  • Clinical Use: Originally used in medical wound healing; now trending in K-beauty for anti-aging
  • Penetration: Smart Capsule Technology helps deliver PDRN to deeper skin layers
Most PDRN research is on injectable forms. Topical efficacy may be milder but users report visible improvements in skin texture and healing.

Hydrolyzed Hyaluronic Acid 29,049ppm (~3%)Proven

Low-molecular-weight hyaluronic acid that penetrates deeper into skin layers. Part of the 11-type HA complex for comprehensive hydration.

  • Efficacy: Clinical tests showed 24.64% improvement in deep skin hydration after single use
  • Mechanism: Attracts and holds up to 1000x its weight in water
  • Synergy: Multiple HA molecular weights target different skin layers simultaneously
Gold-standard hydrating ingredient with decades of research supporting its moisturizing benefits.

Hydrolyzed Collagen PresentProven

Low-molecular collagen peptides that support skin structure and barrier function. Works synergistically with PDRN and HA.

  • Clinical Result: Formula shown to increase skin collagen by 67.6% in efficacy testing
  • Function: Strengthens skin barrier and improves elasticity
  • Absorption: Hydrolyzed form allows better penetration than intact collagen

Niacinamide PresentProven

Vitamin B3 derivative that brightens, strengthens skin barrier, and helps regulate sebum production.

  • Benefits: Reduces hyperpigmentation, minimizes pores, improves skin texture
  • Compatibility: Works well with most other actives including HA and peptides
  • Safety: Well-tolerated by most skin types including sensitive skin

Glutathione PresentPromising

Powerful antioxidant that protects against oxidative stress and supports skin brightening.

  • Function: Master antioxidant that neutralizes free radicals
  • Brightening: May help reduce melanin production for more even skin tone

34 ingredients

Water, Butylene Glycol, Propanediol, Glycerin, Hydrolyzed Hyaluronic Acid (29,049ppm), 1,2-Hexanediol, Niacinamide, Glyceryl Oleate, Lauryl Glucoside, Myristyl Glucoside, Polyglyceryl-6 Laurate, Hydrogenated Lecithin, Glutathione, Hydrolyzed Collagen, Sodium Hyaluronate (800ppm), Coptis Japonica Root Extract, Adenosine, Sodium DNA (100ppm), Hyaluronic Acid (30ppm), Hydrolyzed Sodium Hyaluronate (30ppm), Hydroxypropyltrimonium Hyaluronate (30ppm), Potassium Hyaluronate (30ppm), Sodium Hyaluronate Crosspolymer (30ppm), Sodium Acetylated Hyaluronate (1ppm), Melia Azadirachta Leaf Extract, Melia Azadirachta Flower Extract, Coccinia Indica Fruit Extract, Solanum Melongena (Eggplant) Fruit Extract, Ocimum Sanctum Leaf Extract, Citric Acid, Curcuma Longa (Turmeric) Root Extract, Corallina Officinalis Extract, Sodium Citrate, Pentylene Glycol

FREE FROM: Artificial Fragrance, Parabens, Sulfates, Mineral Oil, Artificial Colors, Silicones, Essential Oils
04

Where it fits in your routine

ROUTINE
1
Cleanser
2
Toner
3
This Serum
4
Treatment
5
Moisturizer
6
Sunscreen

Apply after toner on damp skin. Can be layered 2-3x at night as a sleeping treatment, or mixed with foundation for a dewy finish.

05

How to use

HOW TO USE
1

Daily Care (AM/PM)

After cleansing and toning, dispense 2-3 drops onto fingertips. Gently pat and press into face and neck until fully absorbed.

2

Night Care (Intensive)

Layer the serum 2-3 times in place of a sleeping mask. Allow each layer to absorb before applying the next for plump, hydrated skin by morning.

3

Makeup Care (Glass Skin Hack)

Add 1-2 drops to your foundation or base makeup and mix before application for a radiant, dewy finish.

06

Who is it for?

WHO

Perfect for you if:

  • You want intense hydration and glass skin glow
  • Your skin is dehydrated, dull, or rough-textured
  • You're looking for gentle anti-aging support
  • You want to try the trending PDRN ingredient
  • You're recovering from skin irritation or procedures
  • You're pregnant or breastfeeding and need safe hydration

Consider alternatives if:

  • You have fungal acne (contains FA triggers)
  • You have a severe fish or seafood allergy
  • You prefer matte finishes over dewy looks
  • You need aggressive anti-aging (try retinol instead)
  • You want a richer, cream-based hydrator
07

Skin type compatibility

SKIN TYPES
Dry Skin
Excellent

Outstanding for dry skin. Multi-weight HA provides deep, lasting hydration. May need moisturizer on top in winter.

Oily Skin
Good

Lightweight enough for oily skin, though the dewy finish may feel too much for some. Use sparingly.

Combination
Excellent

Balances well across different zones. Hydrates dry areas without overwhelming oily T-zone.

Sensitive
Excellent

Fragrance-free and low irritation tested. PDRN supports skin healing. Patch test first for very reactive skin.

Acne-Prone
Moderate

Low comedogenic rating, but NOT fungal acne safe. Safe for regular acne but avoid if you have malassezia issues.

08

Results timeline

8+ WEEKS
Immediately

Instant Hydration & Glow

Skin feels immediately plumper, softer, and more radiant. The dewy glass skin effect is visible right after application.

95% noticed instant hydration
1-2 Weeks

Improved Texture & Smoothness

Rough patches become smoother. Skin feels consistently more hydrated throughout the day. Fine dehydration lines diminish.

80% reported smoother skin
4-6 Weeks

Barrier Strengthening & Healing

Skin barrier feels stronger and more resilient. Users recovering from irritation notice faster healing. Overall complexion looks healthier.

70% noticed improved skin health
8+ Weeks

Cumulative Anti-Aging Benefits

With consistent use, some users report subtle improvements in skin elasticity and firmness. PDRN's regenerative effects become more apparent.

60% noticed firmer skin
09

Ratings by platform

680+ REVIEWS
ANUA Official
4.8
Rating
30+
Reviews
Main complaint: Runny texture can drip if not careful with dropper application
Olive Young
4.7
Rating
500+
Reviews
Main complaint: Small bottle size (30ml) runs out quickly with daily use
YesStyle
4.5
Rating
100+
Reviews
Main complaint: May be too dewy/oily for those preferring matte finishes
Amazon
4.4
Rating
50+
Reviews
Main complaint: Newer product with fewer reviews compared to established serums
10

Pros & cons

BALANCED

Praised

  • Instant glass skin glow and plumping effect
  • Deep, long-lasting hydration
  • Fragrance-free and gentle formula
  • Fast-absorbing, non-sticky texture
  • Multi-use (serum, sleeping mask, makeup mixer)
  • 2024 Glow Pick Award winner
  • Helps with post-procedure healing
  • Pregnancy and breastfeeding safe

Criticized

  • Small 30ml size runs out quickly
  • Not fungal acne safe
  • Very watery texture can drip
  • May be too dewy for oily skin
  • PDRN content (100ppm) is relatively low
  • Not suitable for fish allergy sufferers
  • Anti-aging effects are subtle, not dramatic
11

Budget-friendly alternatives (dupes)

DUPES
85% Match
Hyaluronic Acid 2% + B5 Serum
$8.90
Budget Pick

Similar multi-weight HA formula without PDRN. Excellent basic hydration at a fraction of the price. No regenerative benefits but great for pure moisture.

70% Match
PDRN Pink Peptide Serum
$17-37
Similar Price

Higher PDRN concentration (10,000ppm) plus peptides for stronger anti-aging. Less hydrating, more firming. Better for mature skin concerns.

65% Match
PDRN Essence 100
$25
Similar Price

Vegan PDRN alternative derived from ginseng instead of salmon. Good for those avoiding fish-derived ingredients. Milkier texture with ceramides.

12

Comparison with competitors

SIDE-BY-SIDE
PDRN Pink Peptide Serum
Key Ingredient PDRN 10,000ppm + 5 Peptides
Best For Anti-Aging + Firming
Texture Lightweight, Quick Absorbing
Pregnancy Safe Yes
FA Safe No
Turnover Ampoule
Key Ingredient c-PDRN® + Antioxidants
Best For Skin Regeneration + Healing
Texture Comfort-First Serum
Pregnancy Safe Consult Doctor
FA Safe No
PDRN Essence 100
Key Ingredient Ginseng PDRN + 5 Ceramides
Best For Barrier Repair + Vegan Option
Texture Milky, Rich
Pregnancy Safe Yes
FA Safe Check Formula
13

Storage & shelf life

12 MONTHS
Period After Opening (PAO)

12 months after opening

Storage

Store in a cool, dry place away from direct sunlight. Refrigeration optional but can enhance the cooling effect.

Packaging

Glass dropper bottle with emerald-toned serum visible. Protects formula from light degradation.

Travel Friendly

Yes, 30ml is under 100ml TSA limit. Glass bottle—pack carefully to prevent breakage.

13

Frequently asked questions

FAQ

Yes, this serum is considered safe for pregnancy and breastfeeding. It contains no retinoids, salicylic acid, hydroquinone, or other ingredients typically flagged during pregnancy. The formula focuses on gentle hydrating ingredients like hyaluronic acid, niacinamide, and PDRN. However, if you have concerns, always consult your healthcare provider before adding new products to your routine.

No, this serum is NOT fungal acne safe. It contains Glyceryl Oleate and Polyglyceryl-6 Laurate, which are known triggers for malassezia yeast. If you're prone to fungal acne or pityrosporum folliculitis, consider the ANUA PDRN Hyaluronic Acid 100 Moisturizing Cream instead, which has been reported as FA-safe, or look for alternative PDRN serums with cleaner ingredient lists.

Yes! This serum is highly compatible with other actives. It pairs especially well with vitamin C (apply PDRN serum after vitamin C) and can be used alongside retinol to provide extra hydration and support barrier recovery. For AHA/BHA, apply acids first, wait a few minutes, then use this serum to soothe and hydrate. The formula is gentle enough to complement most active-heavy routines.

This serum excels for dry, dehydrated, combination, and sensitive skin types. It's particularly excellent for those seeking intense hydration and the glass skin glow. Oily skin types may find it slightly too dewy—use sparingly or as a night treatment. It's not recommended for those with fungal acne due to potential trigger ingredients.

Hydration benefits are immediate—you'll notice plumper, dewier skin right after application. Texture improvements typically appear within 1-2 weeks of consistent use. For barrier strengthening and the cumulative benefits of PDRN (improved elasticity, faster healing), expect 4-8 weeks of regular use. Anti-aging effects are subtle and build gradually over 2-3 months.

Apply after cleansing and toning, before heavier treatments, moisturizer, and sunscreen. The order is: Cleanser → Toner → (Vitamin C if using) → ANUA PDRN Serum → Other serums/treatments → Moisturizer → Sunscreen (AM). At night, you can layer it 2-3 times as a sleeping treatment or mix it with your night cream.

This serum has a low comedogenic rating of 1/5 and is unlikely to clog pores for most people. The water-based, lightweight formula absorbs quickly without leaving heavy residue. However, it does contain ingredients that may trigger fungal acne specifically (different from regular comedogenic acne). If you have congestion-prone skin but not fungal acne, it should be well-tolerated.

The serum has a PAO (Period After Opening) of 12 months. Store in a cool, dry place away from direct sunlight to maintain efficacy. The 30ml bottle typically lasts 1-2 months with regular twice-daily use (2-3 drops per application). If you notice any changes in color, texture, or smell before the 12-month mark, discontinue use.

— Skincarisma verdict
4.5 / 5 ★★★★★

Verdict: The ANUA PDRN Hyaluronic Acid Capsule 100 Serum delivers on its promise of intense hydration and glass skin glow. The combination of 11 types of hyaluronic acid with PDRN and collagen creates a genuinely effective hydrating serum that outperforms basic HA serums. While the PDRN concentration (100ppm) is lower than competitors like Medicube, the overall formula excels at moisture delivery and barrier support. Best for those prioritizing hydration over aggressive anti-aging. The main drawbacks are the small 30ml size, inability to work for fungal acne sufferers, and somewhat premium pricing. If you want a daily hydrating serum with gentle regenerative benefits and don't have FA concerns, this is an excellent choice that earned its Glow Pick Award recognition.

Browse related

Product Overview

question
lightbulb What are Quick Product Notes?

Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.

muscle Pro Tip Alert!

Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.

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Quick Product Notes

Click on icons for more information
question
lightbulb What are Notable Effects & Ingredients?

Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging «promises» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.

We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.

muscle Pro Tip Alert!

Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.

Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you

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Notable Effects & Ingredients

anti-aging Anti-Aging from 7 ingredient(s):
Hydrolyzed Hyaluronic Acid Niacinamide Hydrolyzed Collagen Adenosine Sodium DNA Hyaluronic Acid Citric Acid
brightening Brightening from 6 ingredient(s):
Glycerin Hydrolyzed Hyaluronic Acid Niacinamide Glutathione Hyaluronic Acid Citric Acid
wound Promotes Wound Healing from 8 ingredient(s):
Glycerin Hydrolyzed Hyaluronic Acid Niacinamide Sodium Hyaluronate Adenosine Hyaluronic Acid Hydrolyzed Sodium Hyaluronate Citric Acid
ache Ache-fighting from 1 ingredient(s):
Niacinamide
question
lightbulb What are Ingredients Related to Skin Type?

Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.

We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.

muscle Pro Tip Alert!

A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.

One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!

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Ingredients Related to Skin Types

Click on icons for more information
dry-skin Dry Skin
3
oily-skin Oily/Acne-Prone Skin
2
sensitive-skin Sensitive Skin
question
lightbulb What is the Ingredient Safety Breakdown?

Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.

muscle Pro Tip Alert!

EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.

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Ingredient Safety Breakdown

EWG Health Ratings
Low risk
Medium risk
High risk
Unknown risk
61% 38%

Product ingredient list

Showing first 5 of 34 ingredients
EWG CIR Ingredient Name & Cosmetic Functions Notes
1 Unknown
Water
Solvent, Skin Conditioning
1 A
Butylene Glycol
Solvent, Skin Conditioning, Masking, Fragrance, Humectant, Viscosity Controlling, Viscositydecreasing Agent
Hydrating
1 Unknown
Propanediol
Solvent, Viscosity Controlling, Viscosity Decreasing Agent
2 A
Glycerin
Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant, Skin Conditioning
brightening Brightening
Promotes Wound Healing
Hydrating
0 Unknown
Hydrolyzed Hyaluronic Acid
Humectant, Skin Conditioning
brightening Brightening
anti-aging Anti-Aging
Promotes Wound Healing
Hydrating
VIEW ALL INGREDIENTS