Peptide 500
Peptide 500
Product Description
Product overview
A lightweight, fast-absorbing anti-aging ampoule serum packed with 45% peptide solution including Copper Tripeptide-1 (GHK-Cu) at 500ppm and Argireline to boost collagen production, firm skin, and visibly reduce fine lines and wrinkles.
9 Peptide Technologies
A comprehensive blend of Copper Tripeptide-1 (GHK-Cu), Argireline, Matrixyl, growth factors, and more to target multiple signs of aging simultaneously.
Texture & feel
SENSORY9 Peptide Technologies
A comprehensive blend of Copper Tripeptide-1 (GHK-Cu), Argireline, Matrixyl, growth factors, and more to target multiple signs of aging simultaneously.
Multi-Weight Hyaluronic Acid
Sodium Hyaluronate provides deep hydration while the ultra-lightweight texture absorbs instantly without any sticky residue.
Centella Asiatica & Beta-Glucan
Soothing botanical extracts calm irritation, strengthen the skin barrier, and support skin repair alongside the peptide complex.
Adenosine Anti-Wrinkle
FDA-recognized anti-wrinkle functional ingredient that boosts collagen production and improves skin firmness from within.
Safety & compatibility
SAFENo retinoids, salicylic acid, hydroquinone, or chemical sunscreens. All peptide and hyaluronic acid ingredients are considered safe during pregnancy.
Contains PEG-60 Hydrogenated Castor Oil, which some databases flag as a potential trigger. Most FA-safe databases rate this product as safe, but sensitive individuals should patch test.
No comedogenic ingredients detected. Oil-free, lightweight formula won't clog pores.
Fragrance-free, alcohol-free, paraben-free, and silicone-free. Centella Asiatica and Beta-Glucan help soothe reactive skin.
Do not use Copper Tripeptide-1 in the same routine as strong Vitamin C (L-Ascorbic Acid) or direct acids (AHA/BHA) as they can reduce peptide effectiveness. Use in separate AM/PM routines.
Can be layered with retinol in the same routine. Peptides and retinoids complement each other well for anti-aging benefits.
Ingredient breakdown
INGREDIENTSCopper Tripeptide-1 (GHK-Cu) 500ppmProven
A naturally occurring copper-peptide complex that stimulates collagen, elastin, and glycosaminoglycan production. One of the most studied peptides in dermatology for wound healing and anti-aging.
- Mechanism: Signals skin to break down damaged collagen and produce new, healthy collagen fibers
- Study: A 1998 study found increased procollagen production in 7 out of 10 participants using copper tripeptide after one month
- Benefits: Improves skin elasticity, clarity, firmness, and reduces fine lines and wrinkles
Acetyl Hexapeptide-8 (Argireline) ActiveProven
Often called "Botox in a jar," this peptide targets expression-related wrinkles by reducing muscle micro-contractions. While not as powerful as Botox, it can smooth dynamic lines with consistent use.
- Mechanism: Inhibits SNARE complex formation, reducing neurotransmitter release at the neuromuscular junction
- Target areas: Forehead lines, crow's feet, and smile lines caused by repeated facial expressions
- Studies: Manufacturer studies show measurable wrinkle reduction with consistent topical application
Adenosine ~1.1-1.4%Proven
A gold-standard anti-wrinkle ingredient recognized by Korean FDA as a functional wrinkle-care active. Naturally found in all living cells, it boosts collagen production and improves tissue repair.
- Function: Stimulates collagen synthesis and improves skin firmness
- Benefit: Smooths skin texture and reduces the appearance of fine lines
- Safety: Naturally occurring compound — extremely well-tolerated by all skin types
Sodium Hyaluronate HumectantProven
The salt form of Hyaluronic Acid — one of the best moisturizing ingredients in skincare. Attracts and holds water in the upper layers of skin for plump, hydrated, dewy-looking skin.
- Mechanism: Can hold up to 1,000x its weight in water, drawing moisture from the environment into skin
- Benefit: Plumps fine lines, improves skin barrier function, and creates a smooth base for other products
Centella Asiatica Extract 0.45-0.7%Proven
A revered K-beauty ingredient containing centelloids (asiaticoside, madecassoside) that reduce inflammation, support skin barrier restoration, and promote collagen synthesis.
- Anti-inflammatory: Clinically shown to calm irritated, red, and sensitive skin
- Barrier repair: Strengthens the skin's natural moisture barrier
- Synergy: Complements peptides by providing a calm, receptive environment for active ingredients
Beta-Glucan SupportingPromising
A polysaccharide derived from yeast or oats that provides deep hydration, antioxidant protection, and skin barrier support. Helps fight free radical damage from environmental stressors.
- Hydration: Penetrates deeper than Hyaluronic Acid for long-lasting moisturization
- Antioxidant: Neutralizes free radicals from UV and pollution exposure
20 ingredients
Water, Methylpropanediol, Butylene Glycol, Glycerin, Pentylene Glycol, PEG-60 Hydrogenated Castor Oil, 1,2-Hexanediol, Sodium Hyaluronate, Propanediol, Ethylhexylglycerin, Copper Tripeptide-1, Adenosine, Beta-Glucan, Disodium EDTA, Centella Asiatica Extract, Houttuynia Cordata Extract, Salvia Hispanica Seed Extract, Caprylyl Glycol, Acetyl Hexapeptide-8, Phenoxyethanol
Where it fits in your routine
ROUTINEApply after cleanser and toner, before heavier serums and moisturizer. Pairs especially well with the Mizon Peptide Ampoule Cream for a complete peptide routine. Use AM & PM.
How to use
HOW TO USECleanse & Tone
Start with a clean face. Apply your toner and let it absorb before moving to the next step.
Dispense 2-3 Drops
Use the dropper to place 2-3 drops into your palm. A little goes a long way — the watery formula spreads easily.
Pat & Press Into Skin
Gently pat and press the ampoule onto your face, neck, and décolleté using upward and outward motions. Avoid rubbing.
Follow with Moisturizer
Allow 30 seconds for absorption, then layer your serum and/or moisturizer. In the AM, finish with sunscreen.
Who is it for?
WHOPerfect for you if:
- You want to address early signs of aging (fine lines, loss of firmness)
- You prefer lightweight, fast-absorbing textures
- You want a fragrance-free, gentle anti-aging product
- You are looking for a peptide serum at an affordable price point
- You want to layer easily under makeup without pilling
- You have sensitive skin and need a non-irritating anti-aging option
Consider alternatives if:
- You have deep, advanced wrinkles — may need stronger actives like retinol
- You prefer rich, thick serum textures — this feels almost like water
- You want visible results in under 2 weeks — peptides work gradually
- You use high-strength L-Ascorbic Acid Vitamin C — conflicts with copper peptides
Skin type compatibility
SKIN TYPESUltra-lightweight, watery texture absorbs instantly. No greasiness, no shine. Oil-free formula won't contribute to excess sebum.
Provides hydration via Hyaluronic Acid and glycerin, but you'll need a richer moisturizer on top. Best as a treatment step, not a standalone hydrator.
Balances beautifully across oily and dry zones. Lightweight enough for the T-zone, hydrating enough for cheeks.
Fragrance-free, alcohol-free, with soothing Centella Asiatica and Beta-Glucan. Minimal ingredient list (20 ingredients) reduces irritation risk.
Non-comedogenic (0/5) and oil-free. Won't clog pores. Contains PEG-60 Hydrogenated Castor Oil which some with fungal acne may want to avoid.
Excellent for early aging signs. For advanced wrinkles and significant sagging, best combined with retinol in a separate routine step.
Results timeline
MONTH 3+Immediate Hydration & Smoothness
Skin feels softer, more supple, and better hydrated. The lightweight formula absorbs instantly and improves overall skin texture.
85% noticed smoother skinImproved Firmness & Elasticity
Copper peptides and Adenosine begin stimulating collagen production. Skin starts to feel tighter and more resilient. Fine lines appear less noticeable.
70% noticed firming effectsVisible Wrinkle Reduction
With consistent twice-daily use, fine lines and expression wrinkles (especially crow's feet and forehead) begin to visibly diminish. Skin tone becomes more even.
60% noticed reduced fine linesCumulative Anti-Aging Benefits
Maximum peptide benefits develop over time. Noticeable improvement in overall skin density, firmness, and youthful appearance. Best results with long-term consistent use.
55% noticed significant improvementRatings by platform
1K+ REVIEWSPros & cons
BALANCEDPraised
- Ultra-lightweight, absorbs instantly without any sticky residue
- Fragrance-free and gentle — suitable for sensitive skin
- Noticeable firming and tightening effect with consistent use
- Layers perfectly under other products and makeup without pilling
- Excellent value for a multi-peptide serum with copper peptides
- Clean, minimal 20-ingredient formula without unnecessary fillers
- Visible improvement in skin texture and smoothness
Criticized
- Very watery texture may feel insubstantial to some users
- Small 30ml bottle may not last long with twice-daily use
- Results are gradual — requires patience (4-8 weeks)
- May not be hydrating enough as a standalone product for dry skin
- Advanced wrinkles and significant sagging may need stronger treatments
- Some users reported occasional breakouts during initial use
Budget-friendly alternatives (dupes)
DUPES
Contains 5 peptide technologies (25.1% actives) including Matrixyl and Argireline with amino acids and HA. Slightly thicker texture. No copper peptides in the base version — need the +Copper Peptides variant for GHK-Cu.
Focused formula with Matrixyl 3000 and Matrixyl Synthe'6 at 10% concentration. Fewer peptide types but higher concentration of Matrixyl. No copper peptides or Argireline. Great entry-level option.
Contains peptides and copper tripeptides to smooth wrinkles and fine lines. Similar lightweight feel. Fewer amino acids and botanical extracts compared to Mizon formula.
Comparison with competitors
SIDE-BY-SIDE
SKIN1004 Matrixyl 10% Boosting Shot Ampoule
COSRX 5 PDRN Collagen Intense Serum
Storage & shelf life
12 MONTHS12 months after opening
Store in a cool, dry place away from direct sunlight. Keep the dropper cap tightly closed after each use to prevent oxidation of copper peptides.
Glass dropper bottle with pipette applicator for precise dispensing
Yes — 30ml is well under the 100ml carry-on limit. Glass bottle, so pack carefully.
Frequently asked questions
FAQYes. Mizon Peptide 500 does not contain retinoids, salicylic acid, hydroquinone, chemical sunscreens, or any other ingredients commonly flagged as unsafe during pregnancy. Peptides, hyaluronic acid, adenosine, and centella asiatica are all considered safe for use during pregnancy and breastfeeding. As always, consult your healthcare provider if you have specific concerns.
This is rated with caution. The formula contains PEG-60 Hydrogenated Castor Oil, which some fungal acne databases (like Skincarisma) flag as a potential malassezia trigger due to its ethoxylated oil structure. However, other databases (SkinSort) rate the product as fungal-acne safe. If you are highly sensitive to fungal acne triggers, patch test first or consider an alternative without PEG-based emulsifiers.
Retinol: Yes — peptides and retinol work well together. You can use them in the same routine (peptide first, then retinol). Vitamin C: Use caution — Copper Tripeptide-1 can interact with L-Ascorbic Acid (pure Vitamin C), potentially reducing the effectiveness of both. Use them in separate routines (e.g., Vitamin C in the AM, Peptide 500 in the PM). AHA/BHA: Avoid using in the same routine — low pH environments from acids can destabilize peptides and reduce their efficacy. Use acids and peptides at different times of day.
Mizon Peptide 500 works well for all skin types. Its ultra-lightweight, watery texture is especially well-suited for oily and combination skin. Sensitive skin types benefit from its fragrance-free, minimal formula with soothing centella and beta-glucan. Dry skin types can use it effectively but should layer a richer moisturizer on top for adequate hydration.
Most users notice improved hydration and skin smoothness within the first 1-2 weeks. Firming and elasticity improvements typically become noticeable around weeks 3-4. Visible reduction in fine lines and wrinkles usually takes 6-8 weeks of consistent twice-daily use. Peptides work cumulatively, so the best results come with long-term use over 3+ months.
Apply after cleansing and toning, but before heavier serums, essences, and moisturizers. As a watery ampoule, it follows the "thinnest to thickest" layering rule. Use it as step 3 in your routine: Cleanser → Toner → Peptide 500 → Serum → Moisturizer → Sunscreen (AM). Mizon recommends pairing it with their Peptide Ampoule Cream for enhanced results.
No. Mizon Peptide 500 has a comedogenic rating of 0/5. Multiple ingredient analysis databases (WIMJ, SkinSort) detect zero comedogenic ingredients. The formula is oil-free and water-based, making it very unlikely to clog pores. It is suitable for acne-prone skin.
The Period After Opening (PAO) is 12 months. The 30ml glass dropper bottle should last approximately 6-8 weeks with twice-daily use (2-3 drops per application). Store in a cool, dry place away from direct sunlight and keep the dropper cap tightly sealed to prevent oxidation of the copper peptides.
Verdict: Mizon Peptide 500 is an outstanding value in the peptide serum category, delivering 9 peptide technologies — including the well-researched Copper Tripeptide-1 and Argireline — in a clean, fragrance-free, 20-ingredient formula. Its ultra-lightweight, watery texture absorbs instantly and layers beautifully, making it ideal for layering-heavy K-beauty routines. While it won't replace professional treatments for deep wrinkles, it offers meaningful firming, smoothing, and hydrating benefits for anyone looking to introduce peptides into their routine without breaking the bank. Best for preventing and addressing early signs of aging with consistent, long-term use.
Product Overview
What are Quick Product Notes?
Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.
Pro Tip Alert!
Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.
Quick Product Notes
Paraben-Free
Paraben-Free
Understanding Parabens
Parabens are a large group of preservatives which are used to prevent bacteria growing in cosmetic formulations. There has been some healthy controversy surrounding them due to a few studies finding paraben presence in breast tumours and breast tissue. However, the majority of the scientific community have deemed these findings non-conclusive due to the limitations of these studies. There's still a lot of support for avoiding parabens following the better safe than sorry route. If you do we completely support you! If you are concerned about the health safety of parabens, then feel free to avoid them by looking out for the Paraben-Free icon. If not, don't worry about it - they do have had one of the longest safety records as preservatives!
Which Ingredients are classified as Paraben?
A product will be paraben-free if it does not contain any of the following parabens:
- Sodium Isobutylparaben
- Sodium Ethylparaben
- Sodium Butylparaben
- Propylparaben
- Isopropylparaben
- Isobutylparaben
- Sodium Propylparaben
- Butylparaben
- Ethylparaben
- Sodium Methylparaben
- Methylparaben
Sulfate-Free
Sulfate-Free
Understanding Sulfates
Sulfates are a large group of ingredients which act as cleansing agents in Cosmetics. They help loosen up the dirt and grime from your skin and hair to allow for water to wash it away with ease. However some sulfates are so good at their job, they can wash off your skin’s own natural oils that keep it moisturised and protected which can lead to dryness and irritation. Most people will find no issues with sulfate, however if you find your skin doesn't like sulfates then free feel to avoid them by looking out for the sulfate-free icon on Skincarisma.
Which ingredients are classified as sulfates?
We've taken the Sulfates which are considered more harsh for our Sulfate-Free status. A product will be Sulfate-Free if it does not contain any of the following Sulfates:
- TEA-Dodecylbenzenesulfonate
- Ammonium Laureth Sulfate
- Sodium Lauryl Sulfate
- PEG-15 Cocamine
- Sodium Laureth Sulfate
- Sodium Cocoyl Sarcosinate
- Sodium C14-16 Olefin Sulfonate
- Dioctyl Sodium Sulfosuccinate
- Ammonium Xylenesulfonate
- Ammonium Lauryl Sulfate
- Sodium Xylenesulfonate
- Sodium Myreth Sulfate
- Sodium Lauryl Sulfoacetate
Alcohol-Free
Alcohol-Free
Understanding Simple Alcohols
Alcohol ingredients are widely used in cosmetics and come in different types. For the most part alcohols are not problematic at all. However one type of alcohols, simple alcohols can be quite drying to the skin because it evaporates very quickly. This can cause irritation which can also lead to other skin complications. These alcohols should never be used alone on your skin, but combined with other cosmetic ingredients, they are normally without issue. However, for some people with sensitive and easily irritable skin, avoiding products with these simple alcohols may be beneficial. If you find your skin doesn't like these simple alcohols, then free feel to avoid them by looking out for the Alcohol-Free icon.
Which Ingredients are classified as Alcohol?
A product will be alcohol-free if it does not contain any of the following alcohol ingredients:
- SD Alcohol
- Alcohol Denat
- Isopropyl Alcohol
- Alcohol
Silicone-Free
Silicone-Free
Understanding Silicones
If you've ever used a skincare, makeup or beauty product that's made your skin look and feel smoother tempoarily - it's likely contained Silicone. They are a popular class of ingredients found in cosmetics due to their smooth, soft, easy-to-spread and smooth properties that help creates an artificial layer/barrier on top of skin or hair (commonly found in conditioners).
For the same reasons they are popularly used, they are also commonly avoided. Anecdotally, many individuals have reported that Silicones cause/excerbate breakouts, irritation, cause a feeling of skin being unable to breathe, cause clumping of cosmetic products and find it difficult to wash off. As a result, those who find them problematic are avoiding them and increasingly, cosmetic companies are avoiding them as well.
If you have had bad experiences with Silicones in the past, or suspect they are problematic then look out for the tick on the Silicone-free label.
Disclaimer
The Silicone-free label only includes the most common Silicone ingredients that have indentified been reported by individuals that could potentially cause issues.
These include: Amodimethicone, Behenoxy Dimethicone, Bis-Aminopropyl Dimethicone, Cetearyl Methicone, Cetyl Dimethicone, Cyclomethicone, Cyclopentasiloxane, Dimethicone, Dimethicone Copolyol, Dimethiconol, Methicone, Phenyl Trimethicone, Phenyl Trimethicone, Stearoxy Dimethicone, Stearyl Dimethicone, Trimethylsilylamodimethicone.
Note, that this does not include all ingredients part of the Silicone class of ingredients.
EU Allergen-Free
EU Allergen-Free
Understanding the Identified Contact Allergens
The EU's Scientific Committee on Consumer Safety (SCCS) has identified and established 26 cosmetic ingredients that are likely contact allergens (potential to cause skin allergies) as demonstrated in clinical or epidemiological studies. The EU's SCCS have recommend cosmetic companies to disclose them on the labels if used and in cases where the concentration exceeds 0.001% in leave-on products and 0.01% in rinse-off products, then they must be labelled.
Look out for the tick on the EU-Allergen free label to know your cosmetic is free from any of the 26 identified cosmetic ingredients.
For more information regarding the EU's Scientific Committee on Consumer Safety, please visit their official website.
Disclaimer
The EU Allergen Free label is for the 26 ingredients identified by the EU SCCS and products will be only flagged if a suspected ingredient is on it's ingredient list. It is possible for cosmetics to contain one of the suspect ingredients without it appearing on the ingredient list due to it not reaching the concentration threshold to disclose it and cosmetic manufacturers choice to not disclose it.
Also note, the EU Allergen Free label is not personalized for your own allergies you may have and it does not constitute as medical advice. For your specific case, always consult your medical professiona such as dermatologist, physician, pharmacist, or health care provider - please read our medical disclaimer for more information.
Fungal Acne (Molassezia) Safe
Fungal Acne (Molassezia) Safe
Understanding Fungal Acne (Pityrosporum Folliculitis/Malassezia Folliculitis)
Pityrosporum Folliculitis/Malassezia folliculitis or simply known as Fungal Acne is a persistent acne-like condition that commonly responds poorly to traditional acne-treating methods. Unlike most cases of Acne where bacteria is the culprit, Fungi is the culprit of Fungal Acne (Hence the name!). There are certain classes & groups of ingredients that have been shown to promote and feed the growth of the Fungal Acne, Fungi such as fatty acids, oils, esters, polysorbates and fermented ingredients.
For more information regarding Fungal Acne, please visit Simple Skincare Science (f.c) - #3 of our Recommend Skincare Resources for an amazing comprehensive guide!
Please Read: How to use the Fungal Acne (Malassezia) Label
At SkinCarisma, we've done our best to identify as many ingredients as possible but note the fungal-free label may not be 100% accurate due to the complexconditions and combination of ingredients that malezzeria can thrive on.
Additionally, products that may contain ingredients that have shown to feed Malassezia may not neccessarily exacerbate the condition due to concentration of ingredient used in the product, this information is simply not available on the products.
As a result, please note this is only an experimental label that can be best used to possible identify problematic products you have used in the past. It is in no way a perfect identifier nor a predictor in whether or not it will exacerbate or cause fungal acne. It will continue to be worked on as more information and research comes to light.
If you find any ingredients you believe should be included, please email us at snails@skincarisma.com.
Disclaimer
Due to the lack of substantial research into this area it is very likely there are other ingredients and class/groups of ingredients that could feed Fungal Acne which have not been indentified.
The Fungal-Safe label does not constitute as medical advice. For your specific case, always consult your medical professiona such as dermatologist, physician, pharmacist, or health care provider - please read our medical disclaimer for more information.
What are Notable Effects & Ingredients?
Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging «promises» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.
We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.
Pro Tip Alert!
Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.
Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you
Notable Effects & Ingredients
Anti-Aging from 5 ingredient(s):
Brightening from 1 ingredient(s):
Promotes Wound Healing from 5 ingredient(s):
What are Ingredients Related to Skin Type?
Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.
We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.
Pro Tip Alert!
A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.
One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!
Ingredients Related to Skin Types
Dry Skin
Oily/Acne-Prone Skin
Sensitive Skin
What is the Ingredient Safety Breakdown?
Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.
Pro Tip Alert!
EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.
Ingredient Safety Breakdown
Product ingredient list
| EWG | CIR | Ingredient Name & Cosmetic Functions | Notes |
|---|---|---|---|
| 1 |
Water
Solvent, Skin Conditioning
|
|
|
| 1 |
Methylpropanediol
Solvent
|
|
|
| 1 |
Butylene Glycol
Solvent, Skin Conditioning, Masking, Fragrance, Humectant, Viscosity Controlling, Viscositydecreasing Agent
|
Hydrating
|
|
| 2 |
Glycerin
Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant, Skin Conditioning
|
Brightening
Promotes Wound Healing
Hydrating
|
|
| 1 |
Pentylene Glycol
Solvent, Skin Conditioning
|
|