Re: Pigment
Re: Pigment
Product Description
Product overview
A highly-saturated, ultra-lightweight brightening serum that uses multi-pathway biotechnology and peptide science to visibly counteract hyperpigmentation, dark spots, and uneven skin tone. Seven distinct active technologies work through different melanin pathways for a comprehensive approach to one of skincare's most stubborn concerns.
Multi-Pathway Brightening
Seven distinct active technologies target melanin production through different mechanisms, preventing adaptation and maximizing efficacy over time.
Texture & feel
SENSORYMulti-Pathway Brightening
Seven distinct active technologies target melanin production through different mechanisms, preventing adaptation and maximizing efficacy over time.
Biotechnology-Driven Actives
Diglucosyl Gallic Acid (Brightenyl) is 60x more potent than kojic acid in brightening skin tone, activated by the skin's own microbiome.
White Shiitake Ferment
An extraordinarily high concentration of purified bio-derivative targets the appearance of dark spots starting within less than a week of use.
Patented Peptide Complex
Four peptides including Tetrapeptide-30 and Oligopeptide-68 reduce UV-induced pigmentation and even out skin contrast areas.
Red Evodia Fruit Derivatives
Borrowed from traditional Chinese medicine, this high-purity extract encourages radiance and evenness from the very first application.
Azelaic Acid Derivative
Potassium Azeloyl Diglycinate offers superior brightening and anti-redness activity compared to azelaic acid itself, with better water solubility.
Safety & compatibility
SAFEContains no retinoids, hydroquinone, salicylic acid, or chemical sunscreens. Independently verified as pregnancy-safe by dermatology reviewers. Always consult your doctor for personalized advice.
Contains Polysorbate 20 and Glycine Soja Oil, which are potential malassezia triggers. Myristoyl Nonapeptide-3 is also flagged. Those with active fungal acne should patch test carefully or choose an alternative.
Lightweight, water-based formula with minimal pore-clogging ingredients. Glycine Soja Oil is present in a low concentration near the bottom of the INCI list.
Do not use in the same routine as Direct Acids, Direct Vitamin C (L-Ascorbic Acid), Resveratrol & Ferulic Acid, or Salicylic Acid. These can destabilize the formula or cause irritation.
Free from alcohol, fragrance, parabens, and silicones. Some users may experience mild tingling upon initial application, which typically subsides quickly.
Avoid unprotected UV exposure when using this formula. Always apply broad-spectrum SPF 30+ during the day, as brightening actives can increase photosensitivity.
Ingredient breakdown
INGREDIENTSWhite Shiitake Ferment (Lentinus Edodes Mycelium Extract) #1 IngredientPromising
A purified bio-derivative from the white shiitake mushroom listed as the very first ingredient, indicating a high concentration. Targets dark spots through a novel mechanism of action distinct from traditional brighteners.
- Mechanism: Works through mushroom-derived tyrosinase inhibition and melanin transfer modulation
- Timeline: NIOD claims visible dark spot targeting begins within less than one week of use
- Position: Listed first on the INCI — before water — indicating an extremely high concentration
Diglucosyl Gallic Acid (Brightenyl / THBG)Proven
A biotechnologically created molecule activated by the skin's own microbiome. Converted to THGA on the skin's surface by resident microorganisms, it acts as a potent brightener, anti-inflammatory, and photoprotectant.
- Potency: 60x more potent than kojic acid in visibly brightening skin tone per manufacturer's clinical data
- Clinical Study: Double-blind, 12-week study on 20 subjects showed visible improvement in skin tone, UV spots, and brightness
- Dual Action: Inhibits melanin synthesis while also modulating skin brightness, yellowness, and redness
Potassium Azeloyl Diglycinate (Azeloyl Glycine)Proven
A patented derivative formed through the condensation of azelaic acid and glycine. Offers superior brightening and anti-redness activity compared to azelaic acid itself, with the advantage of being water-soluble for easier formulation.
- Dual Action: Inhibits tyrosinase activity to reduce melanin production and helps reduce sebum output
- Clinical Evidence: Studies show effective reduction in melanin production after 6 weeks when combined with niacinamide
- Anti-Redness: Successfully used in clinical studies for both rosacea management and melasma treatment
Acetyl Glycyl Beta-Alanine (GenoWhite)Promising
A patented brightening peptide with a very low molecular weight of less than 200 daltons, enabling extremely efficient skin penetration. Inhibits melanin-generating enzymes and hinders the transport of melanin to upper skin layers.
- Molecular Weight: Under 200 daltons — enables deep penetration through the stratum corneum
- Mechanism: Dual action: inhibits tyrosinase and blocks melanin migration to the skin surface
Tetrapeptide-30 ~1.2–1.8%Proven
A patented high-saturation peptide that visibly reduces contrast between areas of varying dermal pigmentation. Clinically tested across multiple skin tones including Caucasian, Asian, and ethnic skin.
- Anti-Inflammatory: Dual action — inhibits tyrosinase and blocks melanin transfer to upper skin layers
- Clinical Testing: Demonstrated skin-brightening, reduction of age spots, decreased redness, and even reduction in acne lesions
- Synergy: Shows synergistic effects when combined with vitamin C derivatives (SAP)
Oligopeptide-68 ~0.95–1.45%Promising
A fully-solubilized, encapsulated liposomal oligopeptide complex that specifically targets UV-induced pigmentation. Delivered via liposomal encapsulation for enhanced stability and bioavailability.
- Clinical Data: A 2016 study found combination with sunscreen was effective and safe for facial melasma, showing results superior to hydroquinone
- UV Focus: Specifically targets the appearance of sun damage-related pigmentation
Red Evodia Fruit Extract (Evodia Rutaecarpa)Traditional
Borrowed from traditional Chinese medicine, this modern high-purity derivative encourages skin radiance and evenness. Provides immediate visible improvement from the first application while supporting long-term brightening.
- Heritage: Used in traditional Chinese medicine for centuries; now extracted using modern biotechnology methods
- Immediate Effect: NIOD claims visible radiance improvement starting with the very first application
27 ingredients
Lentinus Edodes Mycelium Extract, Aqua (Water), Glycerin, Propanediol, Potassium Azeloyl Diglycinate, Butylene Glycol, Acetyl Glycyl Beta-Alanine, Myristoyl Nonapeptide-3, Tetrapeptide-30, Oligopeptide-68, Diglucosyl Gallic Acid, Evodia Rutaecarpa Fruit Extract, Algae Extract, Glycine Soja (Soybean) Oil, Hydrogenated Lecithin, Sodium Oleate, Disodium EDTA, Trisodium Ethylenediamine Disuccinate, Pentylene Glycol, Dimethyl Isosorbide, Ethoxydiglycol, Polysorbate 20, Potassium Sorbate, Sodium Benzoate, 1,2-Hexanediol, Phenoxyethanol, Caprylyl Glycol
Where it fits in your routine
ROUTINEApply directly after cleansing on bare skin. In a NIOD regimen, use after CAIS (Copper Amino Isolate Serum) but before MMHC (Multi-Molecular Hyaluronic Complex). Use AM & PM. Always follow with SPF during the day.
How to use
HOW TO USEShake Lightly
Give the bottle a gentle shake before each use to ensure the active ingredients are evenly distributed throughout the formula.
Dispense 3–4 Drops
Using the dropper, apply 3–4 drops to your fingertips. A little goes a long way with this highly concentrated formula.
Apply to Clean, Dry Skin
Gently press and spread the serum across your entire face or target specific areas of concern. Avoid the eye area.
Allow to Absorb
Wait 1–3 minutes for the serum to fully absorb before layering additional products. Some mild tingling is normal upon first use.
Follow with Hydration & SPF
Layer your hydrating serum and moisturizer on top. During the day, always finish with SPF 30+ — this is essential when using brightening actives.
Who is it for?
WHOPerfect for you if:
- You have sun spots, age spots, or UV-induced hyperpigmentation
- You struggle with post-inflammatory hyperpigmentation (PIH) from acne
- You want a multi-pathway approach to stubborn pigmentation
- You prefer cutting-edge biotechnology-based skincare
- You want to brighten overall skin tone and reduce dullness
- You need a pregnancy-safe brightening option
- You experience redness alongside uneven pigmentation
Consider alternatives if:
- You have hormonal melasma — results may be limited (consider tranexamic acid instead)
- You want rapid results — this serum works gradually over months
- You have active fungal acne (contains potential triggers)
- You prefer to use direct acids or L-Ascorbic Acid in the same routine
- You are on a strict budget — at $72/30ml it is a premium investment
- You need a single all-in-one brightening and exfoliating product
Skin type compatibility
SKIN TYPESLightweight and absorbs well. Some users with oily skin note a slight oily feel from the emollient base — allow extra time to absorb or use only at night.
The emollient base provides a nourishing layer. Glycerin and humectants add hydration. Pairs perfectly with a richer moisturizer on top.
Adapts well across different face zones. Light enough for the T-zone while providing enough nourishment for drier cheeks.
Fragrance-free and alcohol-free. Some users experience mild tingling on first use that subsides. Patch testing is recommended for very reactive skin.
Low comedogenic rating (1/5) and contains anti-inflammatory azelaic acid derivative. Contains trace soybean oil — patch test if highly acne-prone.
Results timeline
MONTHS 4–6+Immediate Radiance Boost
Red Evodia fruit derivatives provide an immediate glow and radiance improvement. Skin feels smoother and more refined. Some users notice a subtle evening of overall tone.
60% noticed improved radianceEarly Brightening & Tone Improvement
White Shiitake Ferment begins targeting dark spots. Overall skin tone starts to look more even and luminous. Redness may begin to diminish thanks to the azelaic acid derivative.
45% noticed lighter spotsVisible Dark Spot Reduction
Multiple brightening pathways are now working synergistically. Users report tangible fading of sun spots and PIH. Overall complexion looks noticeably brighter and more even.
58% reported significant improvementCumulative Long-Term Results
Continued use delivers progressive improvements. Stubborn pigmentation continues to fade. Best results seen with consistent twice-daily use combined with diligent daily SPF protection.
70% satisfied with long-term resultsRatings by platform
45+ REVIEWSPros & cons
BALANCEDPraised
- Multi-pathway approach attacks pigmentation from 7 different angles
- Lightweight, fast-absorbing formula layers well under other products
- Pregnancy-safe — a rare quality in potent brightening serums
- Fragrance-free, alcohol-free, vegan, and cruelty-free formulation
- Actives listed at the top of the INCI — high active concentration
- Effective for UV-induced spots and post-inflammatory hyperpigmentation
- Gentle enough for twice-daily use without significant irritation
- Also helps with redness and overall skin tone evenness
Criticized
- Slow results — most users need 2–3+ months to see significant changes
- Expensive at $72/30ml, especially for long-term daily use
- 15ml bottle runs out quickly with twice-daily full-face application
- Less effective for deep hormonal melasma compared to prescription options
- Dropper packaging allows air in, potentially reducing shelf life
- Cannot be combined with direct acids or L-Ascorbic Acid in the same routine
- Slight oily consistency may not suit very oily skin types
- Limited independent clinical studies on the complete formula
Budget-friendly alternatives (dupes)
DUPESSingle-pathway brightener using alpha arbutin as a tyrosinase inhibitor. Much simpler formula without the peptide technology or multi-pathway approach, but effective for mild hyperpigmentation at a fraction of the price.
A stable vitamin C derivative that brightens skin tone and fights free radicals. Different mechanism of action (antioxidant vs. melanin pathway modulation) but achieves similar brightening results over time.
Shares peptide-based approach and some overlapping ingredients (46% ingredient match). Lacks the specific brightening actives like Brightenyl and White Shiitake Ferment, but offers general skin renewal benefits.
Comparison with competitors
SIDE-BY-SIDEPaula's Choice Discoloration Repair Serum
Storage & shelf life
6 MONTHS6 months after opening. Due to the dropper packaging allowing air exposure, use promptly once opened.
Store in a cool, dry place away from direct sunlight and heat. The dark glass bottle helps protect against light-induced degradation of active ingredients.
Dark glass dropper bottle — protects light-sensitive actives but allows some air exposure. Shake lightly before each use.
Yes — both 15ml and 30ml sizes are well under the 100ml carry-on limit. Glass bottle requires careful packing.
Frequently asked questions
FAQYes. NIOD RE: Pigment does not contain retinoids, hydroquinone, salicylic acid, or chemical sunscreens — the main ingredients to avoid during pregnancy. It has been independently verified as pregnancy-safe by dermatology-focused review sites. However, always consult your healthcare provider before introducing new products during pregnancy or breastfeeding.
Use with caution. While some databases label this product as fungal-acne-safe overall, it does contain a few potential malassezia triggers: Polysorbate 20, Glycine Soja (Soybean) Oil, and Myristoyl Nonapeptide-3. If you have active fungal acne, consider patch testing first or choosing an alternative brightening serum that is strictly FA-safe.
NIOD advises against using RE: Pigment in the same routine as Direct Acids (AHAs/BHAs), Direct Vitamin C (L-Ascorbic Acid), Resveratrol & Ferulic Acid, or Salicylic Acid. You can alternate them — for example, RE: Pigment in the morning and retinol at night, or use vitamin C derivatives like Ascorbyl Glucoside which are generally compatible. Niacinamide and hyaluronic acid are safe to layer with RE: Pigment.
RE: Pigment works well across most skin types. It is particularly excellent for combination and dry skin types. Oily skin types may notice a slight oily feel from the emollient base — if so, use at night only. Sensitive skin generally tolerates it well thanks to the fragrance-free, alcohol-free formula, though mild tingling upon first application is common.
Most users report improved radiance within the first 1–2 weeks. Visible dark spot reduction typically begins around weeks 4–6. Significant, tangible results with consistent use are usually seen at the 2–3 month mark. Stubborn pigmentation may require 6+ months of dedicated use. Patience and diligent SPF application are essential for best results.
Apply RE: Pigment directly after cleansing (and toning, if you use a toner) on bare skin, both AM and PM. In a full NIOD regimen, it goes after CAIS (Copper Amino Isolate Serum) but before MMHC (Multi-Molecular Hyaluronic Complex) and other water-based serums. Always follow with moisturizer and SPF in the morning.
RE: Pigment has a low comedogenic rating of approximately 1 out of 5. The formula is lightweight and primarily water-based. It does contain a small amount of Glycine Soja (Soybean) Oil, but this is listed low in the ingredient list, indicating a minimal concentration. Most users — including those with acne-prone skin — do not experience clogged pores or breakouts from this product.
NIOD RE: Pigment should be used within approximately 6 months after opening. The dropper bottle packaging does allow some air exposure, which can accelerate degradation of active ingredients over time. The dark glass bottle helps protect against light damage. Store in a cool, dry place and shake gently before each use to ensure consistent potency.
Verdict: NIOD RE: Pigment is a scientifically ambitious brightening serum that takes a genuinely unique multi-pathway approach to hyperpigmentation. With seven distinct active technologies — including the standout Brightenyl (claimed 60x more potent than kojic acid) and a high concentration of White Shiitake Ferment — it addresses pigmentation from multiple angles simultaneously. It excels for UV-induced dark spots and post-inflammatory hyperpigmentation, and is one of the few potent brightening serums that is pregnancy-safe. However, it demands patience (2–3+ months for significant results), comes at a premium price ($72/30ml), and shows more limited efficacy for deep hormonal melasma. Best suited for skincare enthusiasts willing to invest in cutting-edge biotechnology and commit to consistent, long-term use alongside diligent sun protection.
Product Overview
Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.
Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.
Quick Product Notes
Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging «promises» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.
We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.
Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.
Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you
Notable Effects & Ingredients
Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.
We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.
A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.
One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!
Ingredients Related to Skin Types
Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.
EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.
Ingredient Safety Breakdown
Product ingredient list
| EWG | CIR | Ingredient Name & Cosmetic Functions | Notes |
|---|---|---|---|
| 0 |
Lentinus Edodes Mycelium Extract
Skin Conditioning
|
|
|
| 1 |
Water
Solvent, Skin Conditioning
|
|
|
| 2 |
Glycerin
Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant, Skin Conditioning
|
Promotes Wound Healing
Hydrating
|
|
| 1 |
Propanediol
Solvent, Viscosity Controlling, Viscosity Decreasing Agent
|
|
|
| 0 |
Potassium Azeloyl Diglycinate
Skin Conditioning
|
Redness
Irritation
Dark Spots
|






