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Rescue Epidermal Repair Serum - Advanced Formula

Rescue Epidermal Repair Serum - Advanced Formula

Product Description

Product overview

Made in Various INTERNATIONAL

A physician-formulated repair serum powered by patented Trioxolane (ozonized ethyl oleate) technology, enhanced with Schisandra, Guava Leaf, and marine biotech ferments. Designed to calm redness, accelerate epidermal healing, neutralize free-radical damage, and dramatically improve skin texture for all skin types — especially those with rosacea, acne, or sensitized skin.

Patented Trioxolane Physician-Formulated Paraben-Free Fragrance-Free SLS-Free Phthalate-Free Cruelty-Free HSA/FSA Eligible 2024 Aestheticians' Choice Award
Pregnancy
Caution
Fungal Acne
No
Comedogenic
1/5
Size
30ml / 1 fl oz
Price
~$136
Type
Repair Serum
Packaging
Airless Pump
Award
2024 Best Serum
Real reviews · YouTube Shorts
Why it's different

Patented Trioxolane Technology

Ozonized Ethyl Oleate delivers stabilized oxygen molecules to repair free-radical and protein damage at the epidermal level.

01

Texture & feel

SENSORY
Consistency
Lightweight Gel
Scent
Mild Herbal/Medicinal
Absorption
Instant
Finish
Smooth / Natural

Patented Trioxolane Technology

Ozonized Ethyl Oleate delivers stabilized oxygen molecules to repair free-radical and protein damage at the epidermal level.

Powerful Anti-Inflammatory

Calms redness, soothes irritation, and reduces the appearance of rosacea and inflamed acne within days of use.

Enhanced Barrier Repair

Advanced formula with Schisandra and Guava Leaf Extract strengthens skin integrity and protects against environmental stressors.

Marine Biotech Ferment

Pseudoalteromonas Ferment Extract boosts skin renewal and radiance through cutting-edge marine biotechnology.

02

Safety & compatibility

SAFE
Pregnancy & Breastfeeding

No retinoids, salicylic acid, or hydroquinone. However, limited safety data on Ozonized Ethyl Oleate and Pseudoalteromonas Ferment Extract during pregnancy. Consult your healthcare provider before use.

Fungal Acne (Malassezia)

Not fungal acne safe. Contains Ozonized Ethyl Oleate (oleate ester) and Pseudoalteromonas Ferment Extract, both of which may feed malassezia yeast.

Low Comedogenic Risk

Rated 1/5 for comedogenicity. Lightweight gel formula is unlikely to clog pores. Suitable for acne-prone skin (non-fungal).

Sensitive Skin Friendly

Free from fragrances, parabens, sulfates, phthalates, and artificial colors. Chirally correct ingredients used where possible.

Retinol & Vitamin C Compatible

Can be layered with retinol, vitamin C, and AHA/BHA products. Its calming properties may actually help buffer irritation from actives.

Post-Procedure Use

Widely recommended by estheticians for post-treatment recovery including after laser, microneedling, chemical peels, and waxing.

03

Ingredient breakdown

INGREDIENTS

Ozonized Ethyl Oleate (Trioxolane) Key ActivePatented

The star ingredient and proprietary technology behind this serum. A natural plant extract derived from sweet wormwood with specialized stabilized oxygen molecules that repair free-radical damage, restore protein integrity, and complete the wound healing process at the cellular level.

  • Mechanism: Delivers active oxygen to skin cells, neutralizing toxins and supporting the immune response
  • Clinical Use: Patented by Osmosis Beauty; shown to calm inflammation, accelerate blemish healing, and improve skin texture
  • Versatility: Effective for rosacea, acne, age spots, uneven skin tone, and post-procedure recovery
Award-winning ingredient — 2024 Aestheticians' Choice Awards Runner Up for Best Face Serum

Schisandra Chinensis Fruit Extract AdaptogenPromising

A powerful adaptogenic berry extract from traditional Chinese medicine, known for its potent antioxidant and anti-inflammatory properties. Helps protect the skin from environmental stressors and blue light damage.

  • Antioxidant: Rich in lignans that scavenge free radicals and reduce oxidative stress on the skin
  • Barrier Support: Strengthens skin resilience against UV, pollution, and blue light exposure
  • Anti-Aging: Supports collagen integrity and helps improve skin firmness and elasticity

Pseudoalteromonas Ferment Extract BiotechPromising

A marine-derived ferment extract obtained from deep-sea bacteria. This biotechnology ingredient promotes skin renewal, enhances radiance, and supports the skin's natural repair mechanisms.

  • Source: Derived from extremophile bacteria found in deep-sea marine environments
  • Skin Renewal: Produces exopolysaccharides that help soothe, hydrate, and promote cell turnover
  • Protection: Helps shield the skin from environmental damage and blue light
Ferment ingredient — not recommended for those with fungal acne (malassezia) concerns

Psidium Guajava Leaf Extract BotanicalProven

Guava leaf extract is rich in morin, a flavonoid clinically shown to possess robust anti-inflammatory, antioxidant, and wound-healing properties.

  • Morin Content: High morin concentration provides clinically proven anti-inflammatory protection
  • Antioxidant: Rich in vitamin C and polyphenols that brighten skin and fight oxidative damage
  • Wound Healing: Supports the skin's natural repair process and accelerates recovery

Glycerin 3-5%Proven

A skin-identical humectant that draws moisture into the skin and maintains the lipid barrier in a healthy liquid crystal state. Non-comedogenic (0) and non-irritating (0).

  • Hydration: Effective from as low as 3%; draws water from the environment into the skin
  • Barrier: Helps maintain the skin's natural moisture barrier and protects against irritation

Hydroxypropyl Cyclodextrin Delivery SystemProven

An advanced delivery vehicle that enhances the penetration and bioavailability of active ingredients. Ensures the Trioxolane reaches deeper skin layers for maximum efficacy.

  • Function: Molecular encapsulation technology that improves ingredient stability and skin absorption
  • Enhancement: Boosts the delivery efficiency of the patented Trioxolane complex

12 ingredients

Water, Ozonized Ethyl Oleate, Hydroxypropyl Cyclodextrin, Glycerin, Schisandra Chinensis Fruit Extract, Pseudoalteromonas Ferment Extract, Psidium Guajava Leaf Extract, Carbomer, Sodium Hydroxide, Propanediol, Xanthan Gum, Glyceryl Caprylate

FREE FROM: Parabens, Sulfates (SLS/SLES), Phthalates, Artificial Fragrances, Artificial Colors, Retinoids, Salicylic Acid, Hydroquinone, Silicones, Mineral Oil, Formaldehyde, Chemical Sunscreens, Gluten, Alcohol (Denat.)
04

Where it fits in your routine

ROUTINE
1
Cleanser
2
Toner / Mist
3
This Serum
4
Treatment Serum
5
Moisturizer
6
Sunscreen (AM)

Apply as your first serum step on clean skin, morning and evening. For enhanced absorption, use after Osmosis Infuse or Boost Nutrient Mist while skin is still damp. Can be followed by additional serums, moisturizer, or SPF.

05

How to use

HOW TO USE
1

Cleanse

Start with a clean face. Use your preferred gentle cleanser to remove makeup, sunscreen, and impurities.

2

Mist (Optional)

Spritz Osmosis Infuse Nutrient Mist onto the face for enhanced penetration. Proceed while skin is still damp.

3

Apply 1–2 Pumps

Dispense 1–2 pumps of Rescue serum onto fingertips and gently massage into the face and neck until fully absorbed.

4

Follow Up

Layer additional serums if needed, then apply moisturizer. In the morning, finish with sunscreen. Use twice daily for best results.

06

Who is it for?

WHO

Perfect for you if:

  • You have rosacea, redness, or chronic skin irritation
  • You struggle with inflammatory or hormonal acne
  • Your skin barrier is compromised or sensitized
  • You want to improve skin texture and age spots
  • You need a post-procedure recovery serum
  • You prefer a clean, minimal ingredient formula
  • You want a physician-formulated, medical-grade product

Consider alternatives if:

  • You have fungal acne (malassezia) — contains oleate ester and ferment
  • You are on a strict budget — premium-priced at $136/30ml
  • You prefer fragrance-free with zero scent — has a mild herbal/medicinal odor
  • You want a deeply hydrating serum — better paired with a heavier moisturizer
  • You are pregnant or breastfeeding — consult your doctor first
07

Skin type compatibility

SKIN TYPES
Oily Skin
Excellent

Lightweight gel absorbs instantly without adding shine or greasiness. Helps control breakouts and reduces inflammation.

Dry Skin
Good

Provides calming and repair benefits, but not deeply hydrating on its own. Pair with a rich moisturizer or facial oil for best results.

Combination Skin
Excellent

Balances well across different face zones. Calms T-zone breakouts while soothing drier cheek areas without heaviness.

Sensitive / Rosacea
Excellent

This is the primary target audience. Fragrance-free, gentle formula specifically designed to calm redness, irritation, and rosacea flares.

Acne-Prone
Excellent

Low comedogenic rating (1/5). Accelerates blemish healing and reduces inflammatory acne. Not suitable for fungal acne specifically.

Mature / Aging Skin
Good

Helps improve texture, age spots, and uneven skin tone. For comprehensive anti-aging, pair with Osmosis StemFactor or a retinal serum.

08

Results timeline

MONTH 2–3
Days 1–3

Immediate Calming Effect

Noticeable reduction in skin redness and irritation. Skin feels soothed and more comfortable. Many users with rosacea report visible improvement within the first few days.

70% noticed calming
Week 1–2

Blemish Healing Acceleration

Active breakouts begin to heal faster. Inflammatory acne lesions flatten and calm down. Skin barrier feels stronger and more resilient.

65% noticed clearer skin
Week 3–4

Texture & Tone Improvement

Visible improvement in overall skin texture and evenness. Pores appear refined. Skin starts to look brighter and more radiant.

60% noticed smoother texture
Month 2–3

Significant Skin Transformation

Cumulative results become dramatic. Age spots and discoloration fade. Rosacea and acne are significantly more manageable. Skin looks healthier and more youthful overall.

80% noticed major improvement
09

Ratings by platform

240+ REVIEWS
Amazon
★★★★½ 4.5
Rating
50+
Reviews
Main complaint: High price point for 1 oz bottle; some note unusual medicinal scent
LovelySkin
4.8
Rating
60+
Reviews
Main complaint: Wish they made a bigger bottle; bottle redesign received mixed feedback
Dermstore
★★★★½ 4.6
Rating
30+
Reviews
Main complaint: Expensive per ounce; runs out quickly with twice-daily use
Brand Website
4.9
Rating
100+
Reviews
Main complaint: Frequently sold out due to high demand; "Sell Out Risk: HIGH"
10

Pros & cons

BALANCED

Praised

  • Dramatic reduction in redness and rosacea flares — many call it "magic in a bottle"
  • Patented Trioxolane technology not found in any other product
  • Minimal, clean ingredient list (only 12 ingredients)
  • Absorbs instantly with no greasy or tacky residue
  • Layers beautifully under makeup and other products
  • Versatile — works on face and body (shaving/waxing irritation)
  • HSA/FSA eligible with subscription savings available
  • Physician-formulated by Dr. Ben Johnson, MD

Criticized

  • Premium price at $136 for only 30ml (1 fl oz)
  • Small bottle runs out fast with twice-daily application
  • Unusual herbal/medicinal scent that takes getting used to
  • Not suitable for fungal acne sufferers
  • Color may change naturally over time (normal but alarming to some)
  • Recent bottle redesign received negative feedback from long-time users
11

Budget-friendly alternatives (dupes)

DUPES
60% Match
Cicaplast Baume B5+
$17.99
Budget Pick

A barrier-repair balm with panthenol (vitamin B5) and madecassoside. Excellent for calming irritation and redness, but thicker texture and different mechanism than Trioxolane. More hydrating but less targeted for acne.

55% Match
Azelaic Acid Suspension 10%
$8.90
Budget Pick

Targets redness and blemishes through azelaic acid rather than ozonized oils. Effective for rosacea and acne at a fraction of the price, but different texture (silicone-based) and can pill under products.

65% Match
Calm Repairing Serum
$34.00
Mid-Range

A calming serum with antioxidants and skin-soothing ingredients designed for sensitive, redness-prone skin. Similar calming approach but without the patented Trioxolane technology or epidermal repair claims.

12

Comparison with competitors

SIDE-BY-SIDE
Regenerating Skin Nectar
Key Ingredient TriHex Technology + Arnica
Size 29.6ml
Total Ingredients 20+
Best For Post-Procedure Recovery
Fragrance None
Price per ml $8.72/ml
Phyto Corrective Gel
Key Ingredient Botanical Blend + Hyaluronic Acid
Size 30ml
Total Ingredients 15+
Best For Sensitive, Discolored Skin
Fragrance None
Price per ml $2.33/ml
Pro-Heal Serum Advance
Key Ingredient Vitamin C + Olive Leaf + Vitamin E
Size 30ml
Total Ingredients 10+
Best For Post-Procedure, Rosacea
Fragrance None
Price per ml $5.27/ml
13

Storage & shelf life

12 MONTHS
Period After Opening (PAO)

12 months after opening

Storage

Store in a cool, dry place away from direct sunlight. Color may naturally change over time — this does not reduce efficacy.

Packaging

Airless pump bottle — protects formula from air and contamination for consistent dosing

Travel Friendly

Yes — 30ml is well under the 100ml TSA carry-on limit

13

Frequently asked questions

FAQ

Caution is advised. The Rescue Advanced Formula does not contain retinoids, salicylic acid, hydroquinone, or chemical sunscreens — the most commonly flagged pregnancy-unsafe ingredients. However, there is limited clinical safety data on Ozonized Ethyl Oleate (Trioxolane) and Pseudoalteromonas Ferment Extract during pregnancy or breastfeeding. We recommend consulting your OB-GYN or dermatologist before incorporating this serum into your routine during pregnancy.

No, this serum is not fungal acne safe. It contains Ozonized Ethyl Oleate, which is an oleate ester that can potentially feed malassezia yeast, and Pseudoalteromonas Ferment Extract, a ferment that is generally avoided by those with fungal acne concerns. If you are prone to fungal acne, consider alternatives like The Ordinary Azelaic Acid Suspension 10% or products verified as FA-safe on folliculitisscout.com.

Yes. Rescue Epidermal Repair Serum is compatible with retinol, vitamin C, AHAs, and BHAs. In fact, its calming and anti-inflammatory properties may help buffer the irritation that often accompanies these actives. Apply Rescue first as a soothing base layer, then follow with your active serum. Many Osmosis users pair it with their Correct Retinal Serum or Catalyst Vitamin C Serum.

Rescue is formulated for all skin types, but it particularly excels for sensitive skin, rosacea-prone skin, and inflammatory acne-prone skin. Reviewers with combination, oily, and dry skin all report positive results. It is especially recommended if your skin is sensitized, irritated, or recovering from a cosmetic procedure. The only exception is fungal acne, where the formula is not recommended.

Most users notice calming and redness reduction within the first 1–3 days. Blemish healing improvements are commonly reported within the first 1–2 weeks. Significant improvements in skin texture, age spots, and overall radiance typically develop over 4–8 weeks of consistent twice-daily use. Some users with chronic rosacea report that the serum becomes indispensable within the first month.

Apply Rescue as your first serum step after cleansing (and toning, if you use a toner). For best results, apply 1–2 pumps on clean skin, optionally after misting with Osmosis Infuse or Boost Nutrient Mist. Follow with additional treatment serums, moisturizer, and sunscreen (AM). Use morning and evening. It can also be applied to the body to soothe shaving or waxing irritation.

Rescue has a low comedogenic rating of 1 out of 5. The lightweight gel formula absorbs quickly and is unlikely to clog pores. Key ingredients like glycerin (comedogenic rating 0) and the overall minimal formula design minimize pore-clogging risk. Many acne-prone users report that this serum actually helps clear their skin rather than cause breakouts. However, as with any new product, patch testing is always recommended.

The Period After Opening (PAO) is 12 months. The airless pump packaging helps protect the formula from oxidation and contamination. Note that the color of the serum may naturally change or vary over time — this is normal and does not reduce the product's efficacy. Store in a cool, dry place away from direct sunlight for optimal shelf life.

— Skincarisma verdict
4.5 / 5 ★★★★★

Verdict: Osmosis Rescue Epidermal Repair Serum - Advanced Formula is a standout physician-formulated serum that delivers on its promise to calm, repair, and transform compromised skin. Its patented Trioxolane technology sets it apart from every competitor on the market, and the overwhelmingly positive reviews from rosacea and acne sufferers speak to its genuine efficacy. The minimal 12-ingredient formula is refreshingly clean. The main drawbacks are the premium $136 price tag for just 30ml and the fact that it is not fungal acne safe. If your primary concern is redness, rosacea, inflammatory acne, or a damaged skin barrier — and budget is not a barrier — this is one of the most effective calming repair serums available.

Product Overview

question
lightbulb What are Quick Product Notes?

Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.

muscle Pro Tip Alert!

Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.

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Quick Product Notes

Click on icons for more information
question
lightbulb What are Notable Effects & Ingredients?

Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging «promises» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.

We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.

muscle Pro Tip Alert!

Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.

Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you

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Notable Effects & Ingredients

brightening Brightening from 1 ingredient(s):
Glycerin
wound Promotes Wound Healing from 1 ingredient(s):
Glycerin
question
lightbulb What are Ingredients Related to Skin Type?

Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.

We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.

muscle Pro Tip Alert!

A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.

One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!

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Ingredients Related to Skin Types

Click on icons for more information
dry-skin Dry Skin
1
oily-skin Oily/Acne-Prone Skin
sensitive-skin Sensitive Skin
question
lightbulb What is the Ingredient Safety Breakdown?

Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.

muscle Pro Tip Alert!

EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.

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Ingredient Safety Breakdown

EWG Health Ratings
Low risk
Medium risk
High risk
Unknown risk
58% 8% 33%

Product ingredient list

Showing first 5 of 12 ingredients
EWG CIR Ingredient Name & Cosmetic Functions Notes
1 Unknown
Water
Solvent, Skin Conditioning
0 Unknown
Hydroxypropyl Cyclodextrin
Masking, Skin Conditioning
2 A
Glycerin
Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant, Skin Conditioning
brightening Brightening
Promotes Wound Healing
Hydrating
0 Unknown
Schisandra Chinensis Fruit Extract
Skin Conditioning
1 Unknown
Pseudoalteromonas Ferment Extract
Humectant
VIEW ALL INGREDIENTS