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Soybean Panthenol Ampoule

Soybean Panthenol Ampoule

Product Description

Product overview

Made in Various INTERNATIONAL

A barrier-repairing ampoule powered by black soybean extract (10,032 ppm) and panthenol (2,550 ppm) that delivers 10 layers of deep hydration while strengthening the skin barrier with a ceramide-cholesterol-fatty acid complex. Clinically shown to boost skin moisture by 599% and reduce transepidermal water loss by 31% in 2 weeks.

Dermatologist Tested Non-Irritating (Clinical Trial) Fragrance-Free Alcohol-Free No Parabens No Silicones Anti-Wrinkle Functional Sensitive Skin Approved
Pregnancy
Yes
Fungal Acne
Caution
Comedogenic
1/5
Size
50ml / 1.69 fl oz
Type
Ampoule
Concern
Barrier Repair
Key Active
Panthenol ~2.5%
pH Level
5.5 – 6.5
Real reviews · YouTube Shorts
Why it's different

10-Layer Moisture Barrier

Ceramide AP, Ceramide NP, cholesterol, and fatty acid complex mimics skin's natural lipid structure for deep, multi-layered hydration that lasts up to 120 hours.

01

Texture & feel

SENSORY
Consistency
Milky Essence
Scent
Fragrance-Free
Absorption
15–20 Seconds
Finish
Dewy, Non-Sticky

10-Layer Moisture Barrier

Ceramide AP, Ceramide NP, cholesterol, and fatty acid complex mimics skin's natural lipid structure for deep, multi-layered hydration that lasts up to 120 hours.

Jeongseon Black Soybean

Sourced from high-altitude Jeongseon, contains 19.5x more anthocyanins and isoflavones than regular soybeans for superior antioxidant and anti-aging benefits.

Nano Niosome Panthenol

Double-layered nanosome technology delivers panthenol (pro-vitamin B5) deep into skin layers, converting to vitamin B5 for enhanced moisture retention and barrier repair.

Clinically Proven Results

599% increase in skin moisturization and 31.08% reduction in transepidermal water loss after 2 weeks. 100% satisfaction in skin barrier improvement in clinical trials.

02

Safety & compatibility

SAFE
Pregnancy & Breastfeeding Safe

Free from retinoids, salicylic acid, hydroquinone, and chemical sunscreens. All ingredients are considered safe during pregnancy and breastfeeding.

Fungal Acne (Malassezia) — Use with Caution

Contains stearic acid, caprylic/capric triglyceride, polyglyceryl-10 stearate, and sorbitan olivate which may feed malassezia yeast. Check with your dermatologist if you are fungal acne prone.

Low Comedogenic Risk (1/5)

Formula is lightweight and non-comedogenic. Contains no heavy oils or known pore-clogging ingredients at significant concentrations. Suitable for acne-prone skin.

Sensitive Skin Certified

Passed clinical skin irritation test and certified as non-irritating. Fragrance-free, alcohol-free, and silicone-free formulation. Low irritation potential confirmed by WIMJ analysis.

Retinol & Actives Compatible

Safe to layer with retinol, vitamin C, AHA, BHA, and niacinamide. Panthenol and ceramides actually help buffer irritation from active ingredients.

Soy Allergy Note

Contains Glycine Max (Soybean) Seed Extract. If you have a known soy allergy, perform a patch test before full use or consult your dermatologist.

03

Ingredient breakdown

INGREDIENTS

Black Soybean (Glycine Max) Seed Extract ~1% (10,032 ppm)Proven

Sourced from the high-altitude Jeongseon region of South Korea, this black soybean extract is rich in proteins, isoflavones, anthocyanins, and vitamin B. It provides deep nourishment while supporting skin elasticity and tone evenness.

  • Antioxidant: Contains 19.5x more anthocyanins and isoflavones than regular soybeans, protecting against free radical damage
  • Anti-Aging: Rich in glycitein, a powerful anti-aging substance, at 4x the concentration of ordinary soybeans
  • Brightening: Genistein inhibits melanin production while vitamin E provides natural lightening properties for more even skin tone

Panthenol (Pro-Vitamin B5) ~2.5% (2,550 ppm)Proven

Delivered via nano niosome double-layered technology for enhanced penetration. Once absorbed, panthenol converts to vitamin B5, a potent humectant and barrier-repair agent that strengthens skin from within.

  • Hydration: Humectant that attracts and holds water in the upper skin layers, comparable to hyaluronic acid
  • Barrier Repair: Stimulates production of skin lipids crucial for a strong and healthy skin barrier
  • Anti-Inflammatory: Reduces irritation caused by other ingredients and environmental stressors
  • Wound Healing: Promotes fibroblast proliferation and collagen production for faster skin repair
Effective concentration range: 1.6%–2.4% per WIMJ analysis. This product delivers panthenol at the upper end of its effective range.

Ceramide Complex (AP + NP) Optimized RatioProven

Two types of ceramides naturally found in the skin's upper layer, combined with cholesterol and stearic acid (fatty acid) in a ratio that mimics the skin's own lipid structure for maximum barrier repair.

  • Barrier Function: Ceramides make up ~50% of the lipids between skin cells, essential for barrier integrity
  • Ceramide AP (Ceramide 6): Helps bond dead skin cells together to create a protective barrier
  • Ceramide NP (Ceramide 3): Works synergistically with Ceramide AP for enhanced moisture retention
  • Triple Lipid Complex: Ceramide + Cholesterol + Fatty Acid ratio mirrors natural skin composition

Adenosine Functional LevelProven

A KFDA-approved anti-wrinkle functional ingredient that stimulates collagen production and improves skin elasticity. Present at the concentration required for official anti-wrinkle classification in Korean cosmetics.

  • Anti-Wrinkle: Increases collagen production to reduce fine lines and improve skin firmness
  • Timeline: Results typically visible after 6+ weeks of consistent use

Sodium Hyaluronate 0.2%–0.8%Proven

The salt form of hyaluronic acid with a smaller molecular weight for better skin penetration. Attracts and retains up to 1,000x its weight in water for intense hydration.

  • Deep Hydration: Smaller molecular size than hyaluronic acid allows it to penetrate more deeply into the skin
  • Plumping Effect: Helps fill in fine lines and create a smoother, more supple skin surface

32 ingredients

Water, Glycerin, Dipropylene Glycol, 1,2-Hexanediol, Glycine Max (Soybean) Seed Extract (10,032ppm), Panthenol (2,550ppm), Ceramide AP, Ceramide NP, Stearic Acid, Cholesterol, Ulmus Davidiana Root Extract, Amaranthus Caudatus Seed Extract, Hydrogenated Lecithin, Sodium Hyaluronate, Pentaerythrityl Tetraethylhexanoate, Hexyldecyl Ethylhexanoate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Cetearyl Olivate, Sorbitan Olivate, Tromethamine, Butylene Glycol, Adenosine, Disodium EDTA, Polyglyceryl-10 Stearate, Caprylic/Capric Triglyceride, Glycosphingolipids, Glyceryl Stearate, Cetearyl Alcohol, Xanthan Gum, Tetraacetylphytosphingosine, Ethylhexylglycerin, Hydroxyacetophenone

FREE FROM: Fragrance, Alcohol (Denat.), Parabens, Sulfates, Silicones, Essential Oils, Mineral Oil, Artificial Colorants, PEGs, Phenoxyethanol
04

Where it fits in your routine

ROUTINE
1
Cleanser
2
Toner
3
Essence
4
This Ampoule
5
Moisturizer
6
Sunscreen

Use AM and PM after toner. Can be layered 2–3 times for extra hydration. Pairs perfectly with the Round Lab Soybean Panthenol Cream as a follow-up moisturizer.

05

How to use

HOW TO USE
1

Cleanse & Tone

Start with a clean face. Apply your toner and let it absorb fully before proceeding.

2

Dispense

Take 2–3 drops of the ampoule onto your fingertips or palm. A little goes a long way with this concentrated formula.

3

Apply & Pat

Spread evenly across your entire face and neck. Gently pat with your fingertips to promote full absorption into the skin.

4

Layer (Optional)

For extra hydration or severely dry/damaged skin, apply a second layer once the first has absorbed. Follow with moisturizer to seal in hydration.

06

Who is it for?

WHO

Perfect for you if:

  • Your skin barrier is damaged or compromised from over-exfoliation or harsh actives
  • You experience persistent dryness, flakiness, or rough texture
  • You want a fragrance-free, low-irritation hydrating ampoule
  • You need a soothing product to pair with retinol or AHA/BHA routines
  • You have sensitive skin that reacts to most serums
  • You want clinically proven barrier-repair benefits

Consider alternatives if:

  • You have confirmed fungal acne (contains potential FA triggers)
  • You prefer a completely watery, water-thin serum texture
  • You want a product with high-concentration actives like vitamin C or niacinamide
  • You have a known soy allergy
  • You want a multi-purpose serum targeting brightening or pigmentation
07

Skin type compatibility

SKIN TYPES
Dry Skin
Excellent

The ceramide-panthenol complex delivers exactly what dry skin needs: deep hydration and barrier repair. Layer multiple times for extra moisture.

Sensitive Skin
Excellent

Clinically certified as non-irritating. Fragrance-free, alcohol-free, and silicone-free. Panthenol actively soothes and calms reactive skin.

Combination Skin
Excellent

Milky essence texture absorbs quickly without feeling heavy. Hydrates dry zones without adding excess oiliness to the T-zone.

Oily Skin
Good

Lightweight and non-greasy formula. Use a single thin layer. The dewy finish may feel too rich for very oily skin in humid climates.

Acne-Prone Skin
Good

Low comedogenic rating (1/5) and no heavy oils. However, if your acne is fungal (malassezia), check the FA trigger ingredients first.

08

Results timeline

WEEK 6+
Day 1–3

Immediate Hydration Boost

Skin feels softer, smoother, and more comfortable immediately after application. The milky texture absorbs without stickiness, leaving a dewy glow.

90% noticed instant hydration
Week 1–2

Barrier Strengthening Begins

Transepidermal water loss reduced by up to 31.08%. Skin feels less tight and reactive. Flakiness and rough patches start to diminish. Clinical trials showed 100% satisfaction in improved skin barrier.

100% reported improved skin barrier (clinical trial)
Week 3–4

Visible Texture Improvement

Skin texture becomes noticeably smoother and more supple. Dead skin cells are alleviated. Overall complexion appears more even and healthy.

85% noticed smoother texture
Week 6+

Anti-Wrinkle & Long-Term Benefits

Adenosine's collagen-boosting effects become visible. Fine lines appear reduced, skin elasticity improves. Continued use maintains optimal barrier function and hydration.

75% noticed firmer, more elastic skin
09

Ratings by platform

730+ REVIEWS
Amazon
4.7
Rating
200+
Reviews
Main complaint: Small bottle size (50ml) for the price point
YesStyle
4.8
Rating
150+
Reviews
Main complaint: Shipping time from Asia can be long for international orders
Stylevana
4.7
Rating
80+
Reviews
Main complaint: Can feel too dewy for oily skin types in summer
Round Lab Official
4.9
Rating
300+
Reviews
Main complaint: Wish it came in a larger size for daily use
10

Pros & cons

BALANCED

Praised

  • Excellent barrier repair with clinically proven results (599% moisture increase)
  • Milky texture absorbs fast with zero stickiness
  • Fragrance-free, alcohol-free — ideal for sensitive and reactive skin
  • Triple ceramide-cholesterol-fatty acid complex mirrors skin's natural lipids
  • Can be layered without pilling or heaviness
  • Certified non-irritating through clinical trials
  • Works well under makeup and with other actives

Criticized

  • Small 50ml bottle may not last long with twice-daily use
  • Not fungal acne safe due to several FA triggers
  • May feel too dewy for very oily skin in humid climates
  • Panthenol concentration (~2.5%) is lower than some competitors (PURITO at 10%)
  • Contains soy — not suitable for those with soy allergies
  • Dropper packaging less hygienic than airless pump
11

Budget-friendly alternatives (dupes)

DUPES
70% Match
Balancium Comfort Ceramide Cream
$24.40
Similar Price

Higher panthenol concentration (10%) but in a cream format rather than ampoule. Contains silicones and sunflower seed oil. Lacks the ceramide-cholesterol-fatty acid triple complex and soybean extract. Better for those wanting pure panthenol power.

65% Match
Mighty Bamboo Panthenol Cream
$16.00
Budget Pick

Features 10% panthenol with bamboo extract instead of soybean. Includes niacinamide and squalane. Cream format (100ml) offers better value per ml. Lacks ceramide complex but adds centella-derived actives for soothing.

55% Match
COSRX Balancium B5 D-Panthenol Ampoule
$18.00
Budget Pick

Ultra-concentrated 30% panthenol ampoule (2x10ml) designed to be mixed into other products. Minimal formula with hyaluronic acid. No ceramides or soybean extract. Best as a booster rather than standalone product.

12

Comparison with competitors

SIDE-BY-SIDE
Mighty Bamboo Panthenol Cream
Key Actives Panthenol 10% + Niacinamide + Squalane
Size 100ml
Format Cream
Ceramides No
Fragrance None
Fungal Acne Safe Partially
Clinical Data Yes — 55.65% water loss improvement
Balancium Comfort Ceramide Cream
Key Actives Panthenol 10% + 5 Types Hyaluronic Acid
Size 50ml
Format Cream
Ceramides No
Fragrance None
Fungal Acne Safe No
Clinical Data Limited
Mighty Bamboo Panthenol Serum
Key Actives Panthenol 13% + Niacinamide + Ectoin
Size 50ml
Format Serum
Ceramides No
Fragrance None
Fungal Acne Safe Partially
Clinical Data Yes — barrier repair clinical study
13

Storage & shelf life

12 MONTHS
Period After Opening (PAO)

12 months after opening

Storage

Store in a cool, dry place away from direct sunlight. Keep the cap tightly closed after each use to preserve active ingredients.

Packaging

Glass bottle with dropper dispenser for controlled, hygienic application

Travel Friendly

Yes — 50ml is under the 100ml TSA carry-on limit. Glass bottle requires careful packing.

13

Frequently asked questions

FAQ

Yes. This ampoule is considered safe during pregnancy and breastfeeding. It contains no retinoids, salicylic acid, hydroquinone, chemical sunscreens, or any other ingredients flagged as unsafe for pregnant or nursing individuals. The key actives — panthenol, ceramides, glycerin, soybean extract, and hyaluronic acid — are all well-established as safe for use during pregnancy. As always, consult your healthcare provider if you have specific concerns.

Not entirely. While many of the core ingredients (panthenol, glycerin, sodium hyaluronate) are fungal acne safe, the formula contains several potential malassezia triggers: stearic acid, caprylic/capric triglyceride, polyglyceryl-10 stearate, sorbitan olivate, and glyceryl stearate. If you have confirmed fungal acne or are very prone to it, consider alternatives like the Round Lab 1025 Dokdo Ampoule or the Pine Calming Cica Ampoule, which are fungal acne safe according to SkinSort.

Yes, this ampoule is an excellent companion to active ingredients. Panthenol and ceramides help buffer irritation caused by retinol, AHAs, BHAs, and vitamin C. Apply your actives first (such as retinol or vitamin C serum), wait a few minutes, then apply the Soybean Panthenol Ampoule to soothe and protect the skin barrier. This layering approach helps you get the benefits of potent actives while minimizing dryness, redness, and irritation.

This ampoule is best suited for dry, sensitive, and combination skin types. It excels at repairing damaged skin barriers and providing deep hydration without heaviness. It's particularly ideal for those who have over-exfoliated, used too many actives, or have naturally thin and reactive skin. Oily skin types can also benefit but should apply a single thin layer. It's clinically certified as non-irritating, making it one of the gentlest barrier-repair options available.

Immediate hydration and skin softening are noticeable from the first application. Barrier repair and reduced transepidermal water loss (31.08% reduction) are clinically demonstrated within 2 weeks of consistent use. Texture improvements typically appear by weeks 3–4, while the anti-wrinkle benefits from adenosine require at least 6 weeks of continued use. For best results, use twice daily (AM and PM) without interruption.

Apply after cleansing and toning, in the ampoule/serum step of your routine (Step 4). The order is: Cleanser → Toner → Essence (optional) → This Ampoule → Moisturizer → Sunscreen (AM). If using actives like retinol or vitamin C, apply those before this ampoule. The brand also suggests it can be used as the last step, applied like a barrier-sealing layer over other products.

This ampoule has a low comedogenic rating of 1 out of 5. It does not contain heavy oils, mineral oil, or highly comedogenic ingredients at significant concentrations. The key actives (panthenol: comedogenic rating 0, glycerin: comedogenic rating 0) are non-pore-clogging. Cetearyl alcohol has a comedogenic rating of 2 but is present in a small amount as a texture agent. For most people, this product should not cause breakouts or clogged pores.

The Period After Opening (PAO) is 12 months. Once opened, use within one year for optimal efficacy. Store in a cool, dry place away from direct sunlight and high temperatures. Keep the dropper cap tightly sealed after each use to prevent contamination and oxidation of the active ingredients. The 50ml bottle typically lasts 6–8 weeks with twice-daily use.

— Skincarisma verdict
4.5 / 5 ★★★★★

Verdict: The Round Lab Soybean Panthenol Ampoule is an outstanding barrier-repair ampoule that delivers clinically proven hydration results. Its unique combination of nano niosome panthenol, Jeongseon black soybean extract, and a skin-identical ceramide-cholesterol-fatty acid complex sets it apart from competitors that rely on panthenol alone. The fragrance-free, non-irritating formula makes it a safe choice for sensitive and compromised skin. The only drawbacks are its small 50ml size and the presence of several fungal acne triggers. If your skin is dry, damaged, or in need of serious barrier support, this ampoule is one of the best K-beauty options available today.

Product Overview

question
lightbulb What are Quick Product Notes?

Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.

muscle Pro Tip Alert!

Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.

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Quick Product Notes

Click on icons for more information
question
lightbulb What are Notable Effects & Ingredients?

Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging «promises» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.

We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.

muscle Pro Tip Alert!

Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.

Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you

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Notable Effects & Ingredients

anti-aging Anti-Aging from 3 ingredient(s):
Ceramide AP Ceramide NP Adenosine
brightening Brightening from 1 ingredient(s):
Glycerin
wound Promotes Wound Healing from 4 ingredient(s):
Glycerin Panthenol Sodium Hyaluronate Adenosine
question
lightbulb What are Ingredients Related to Skin Type?

Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.

We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.

muscle Pro Tip Alert!

A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.

One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!

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Ingredients Related to Skin Types

Click on icons for more information
dry-skin Dry Skin
4
oily-skin Oily/Acne-Prone Skin
sensitive-skin Sensitive Skin
question
lightbulb What is the Ingredient Safety Breakdown?

Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.

muscle Pro Tip Alert!

EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.

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Ingredient Safety Breakdown

EWG Health Ratings
Low risk
Medium risk
High risk
Unknown risk
62% 37%

Product ingredient list

Showing first 5 of 32 ingredients
EWG CIR Ingredient Name & Cosmetic Functions Notes
1 Unknown
Water
Solvent, Skin Conditioning
2 A
Glycerin
Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant, Skin Conditioning
brightening Brightening
Promotes Wound Healing
Hydrating
1 A
Dipropylene Glycol
Fragrance, Solvent, Viscosity Decreasing Agent, Masking, Viscosity Controlling
1 A
1,2-Hexanediol
Solvent, Skin Conditioning
Hydrating
0 Unknown
Glycine Max Seed Extract
Skin Conditioning, Skin Protecting
VIEW ALL INGREDIENTS