Soybean Panthenol Ampoule
Soybean Panthenol Ampoule
Product Description
Product overview
A barrier-repairing ampoule powered by black soybean extract (10,032 ppm) and panthenol (2,550 ppm) that delivers 10 layers of deep hydration while strengthening the skin barrier with a ceramide-cholesterol-fatty acid complex. Clinically shown to boost skin moisture by 599% and reduce transepidermal water loss by 31% in 2 weeks.
10-Layer Moisture Barrier
Ceramide AP, Ceramide NP, cholesterol, and fatty acid complex mimics skin's natural lipid structure for deep, multi-layered hydration that lasts up to 120 hours.
Texture & feel
SENSORY10-Layer Moisture Barrier
Ceramide AP, Ceramide NP, cholesterol, and fatty acid complex mimics skin's natural lipid structure for deep, multi-layered hydration that lasts up to 120 hours.
Jeongseon Black Soybean
Sourced from high-altitude Jeongseon, contains 19.5x more anthocyanins and isoflavones than regular soybeans for superior antioxidant and anti-aging benefits.
Nano Niosome Panthenol
Double-layered nanosome technology delivers panthenol (pro-vitamin B5) deep into skin layers, converting to vitamin B5 for enhanced moisture retention and barrier repair.
Clinically Proven Results
599% increase in skin moisturization and 31.08% reduction in transepidermal water loss after 2 weeks. 100% satisfaction in skin barrier improvement in clinical trials.
Safety & compatibility
SAFEFree from retinoids, salicylic acid, hydroquinone, and chemical sunscreens. All ingredients are considered safe during pregnancy and breastfeeding.
Contains stearic acid, caprylic/capric triglyceride, polyglyceryl-10 stearate, and sorbitan olivate which may feed malassezia yeast. Check with your dermatologist if you are fungal acne prone.
Formula is lightweight and non-comedogenic. Contains no heavy oils or known pore-clogging ingredients at significant concentrations. Suitable for acne-prone skin.
Passed clinical skin irritation test and certified as non-irritating. Fragrance-free, alcohol-free, and silicone-free formulation. Low irritation potential confirmed by WIMJ analysis.
Safe to layer with retinol, vitamin C, AHA, BHA, and niacinamide. Panthenol and ceramides actually help buffer irritation from active ingredients.
Contains Glycine Max (Soybean) Seed Extract. If you have a known soy allergy, perform a patch test before full use or consult your dermatologist.
Ingredient breakdown
INGREDIENTSBlack Soybean (Glycine Max) Seed Extract ~1% (10,032 ppm)Proven
Sourced from the high-altitude Jeongseon region of South Korea, this black soybean extract is rich in proteins, isoflavones, anthocyanins, and vitamin B. It provides deep nourishment while supporting skin elasticity and tone evenness.
- Antioxidant: Contains 19.5x more anthocyanins and isoflavones than regular soybeans, protecting against free radical damage
- Anti-Aging: Rich in glycitein, a powerful anti-aging substance, at 4x the concentration of ordinary soybeans
- Brightening: Genistein inhibits melanin production while vitamin E provides natural lightening properties for more even skin tone
Panthenol (Pro-Vitamin B5) ~2.5% (2,550 ppm)Proven
Delivered via nano niosome double-layered technology for enhanced penetration. Once absorbed, panthenol converts to vitamin B5, a potent humectant and barrier-repair agent that strengthens skin from within.
- Hydration: Humectant that attracts and holds water in the upper skin layers, comparable to hyaluronic acid
- Barrier Repair: Stimulates production of skin lipids crucial for a strong and healthy skin barrier
- Anti-Inflammatory: Reduces irritation caused by other ingredients and environmental stressors
- Wound Healing: Promotes fibroblast proliferation and collagen production for faster skin repair
Ceramide Complex (AP + NP) Optimized RatioProven
Two types of ceramides naturally found in the skin's upper layer, combined with cholesterol and stearic acid (fatty acid) in a ratio that mimics the skin's own lipid structure for maximum barrier repair.
- Barrier Function: Ceramides make up ~50% of the lipids between skin cells, essential for barrier integrity
- Ceramide AP (Ceramide 6): Helps bond dead skin cells together to create a protective barrier
- Ceramide NP (Ceramide 3): Works synergistically with Ceramide AP for enhanced moisture retention
- Triple Lipid Complex: Ceramide + Cholesterol + Fatty Acid ratio mirrors natural skin composition
Adenosine Functional LevelProven
A KFDA-approved anti-wrinkle functional ingredient that stimulates collagen production and improves skin elasticity. Present at the concentration required for official anti-wrinkle classification in Korean cosmetics.
- Anti-Wrinkle: Increases collagen production to reduce fine lines and improve skin firmness
- Timeline: Results typically visible after 6+ weeks of consistent use
Sodium Hyaluronate 0.2%–0.8%Proven
The salt form of hyaluronic acid with a smaller molecular weight for better skin penetration. Attracts and retains up to 1,000x its weight in water for intense hydration.
- Deep Hydration: Smaller molecular size than hyaluronic acid allows it to penetrate more deeply into the skin
- Plumping Effect: Helps fill in fine lines and create a smoother, more supple skin surface
32 ingredients
Water, Glycerin, Dipropylene Glycol, 1,2-Hexanediol, Glycine Max (Soybean) Seed Extract (10,032ppm), Panthenol (2,550ppm), Ceramide AP, Ceramide NP, Stearic Acid, Cholesterol, Ulmus Davidiana Root Extract, Amaranthus Caudatus Seed Extract, Hydrogenated Lecithin, Sodium Hyaluronate, Pentaerythrityl Tetraethylhexanoate, Hexyldecyl Ethylhexanoate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Cetearyl Olivate, Sorbitan Olivate, Tromethamine, Butylene Glycol, Adenosine, Disodium EDTA, Polyglyceryl-10 Stearate, Caprylic/Capric Triglyceride, Glycosphingolipids, Glyceryl Stearate, Cetearyl Alcohol, Xanthan Gum, Tetraacetylphytosphingosine, Ethylhexylglycerin, Hydroxyacetophenone
Where it fits in your routine
ROUTINEUse AM and PM after toner. Can be layered 2–3 times for extra hydration. Pairs perfectly with the Round Lab Soybean Panthenol Cream as a follow-up moisturizer.
How to use
HOW TO USECleanse & Tone
Start with a clean face. Apply your toner and let it absorb fully before proceeding.
Dispense
Take 2–3 drops of the ampoule onto your fingertips or palm. A little goes a long way with this concentrated formula.
Apply & Pat
Spread evenly across your entire face and neck. Gently pat with your fingertips to promote full absorption into the skin.
Layer (Optional)
For extra hydration or severely dry/damaged skin, apply a second layer once the first has absorbed. Follow with moisturizer to seal in hydration.
Who is it for?
WHOPerfect for you if:
- Your skin barrier is damaged or compromised from over-exfoliation or harsh actives
- You experience persistent dryness, flakiness, or rough texture
- You want a fragrance-free, low-irritation hydrating ampoule
- You need a soothing product to pair with retinol or AHA/BHA routines
- You have sensitive skin that reacts to most serums
- You want clinically proven barrier-repair benefits
Consider alternatives if:
- You have confirmed fungal acne (contains potential FA triggers)
- You prefer a completely watery, water-thin serum texture
- You want a product with high-concentration actives like vitamin C or niacinamide
- You have a known soy allergy
- You want a multi-purpose serum targeting brightening or pigmentation
Skin type compatibility
SKIN TYPESThe ceramide-panthenol complex delivers exactly what dry skin needs: deep hydration and barrier repair. Layer multiple times for extra moisture.
Clinically certified as non-irritating. Fragrance-free, alcohol-free, and silicone-free. Panthenol actively soothes and calms reactive skin.
Milky essence texture absorbs quickly without feeling heavy. Hydrates dry zones without adding excess oiliness to the T-zone.
Lightweight and non-greasy formula. Use a single thin layer. The dewy finish may feel too rich for very oily skin in humid climates.
Low comedogenic rating (1/5) and no heavy oils. However, if your acne is fungal (malassezia), check the FA trigger ingredients first.
Results timeline
WEEK 6+Immediate Hydration Boost
Skin feels softer, smoother, and more comfortable immediately after application. The milky texture absorbs without stickiness, leaving a dewy glow.
90% noticed instant hydrationBarrier Strengthening Begins
Transepidermal water loss reduced by up to 31.08%. Skin feels less tight and reactive. Flakiness and rough patches start to diminish. Clinical trials showed 100% satisfaction in improved skin barrier.
100% reported improved skin barrier (clinical trial)Visible Texture Improvement
Skin texture becomes noticeably smoother and more supple. Dead skin cells are alleviated. Overall complexion appears more even and healthy.
85% noticed smoother textureAnti-Wrinkle & Long-Term Benefits
Adenosine's collagen-boosting effects become visible. Fine lines appear reduced, skin elasticity improves. Continued use maintains optimal barrier function and hydration.
75% noticed firmer, more elastic skinRatings by platform
730+ REVIEWSPros & cons
BALANCEDPraised
- Excellent barrier repair with clinically proven results (599% moisture increase)
- Milky texture absorbs fast with zero stickiness
- Fragrance-free, alcohol-free — ideal for sensitive and reactive skin
- Triple ceramide-cholesterol-fatty acid complex mirrors skin's natural lipids
- Can be layered without pilling or heaviness
- Certified non-irritating through clinical trials
- Works well under makeup and with other actives
Criticized
- Small 50ml bottle may not last long with twice-daily use
- Not fungal acne safe due to several FA triggers
- May feel too dewy for very oily skin in humid climates
- Panthenol concentration (~2.5%) is lower than some competitors (PURITO at 10%)
- Contains soy — not suitable for those with soy allergies
- Dropper packaging less hygienic than airless pump
Budget-friendly alternatives (dupes)
DUPESHigher panthenol concentration (10%) but in a cream format rather than ampoule. Contains silicones and sunflower seed oil. Lacks the ceramide-cholesterol-fatty acid triple complex and soybean extract. Better for those wanting pure panthenol power.
Features 10% panthenol with bamboo extract instead of soybean. Includes niacinamide and squalane. Cream format (100ml) offers better value per ml. Lacks ceramide complex but adds centella-derived actives for soothing.
Ultra-concentrated 30% panthenol ampoule (2x10ml) designed to be mixed into other products. Minimal formula with hyaluronic acid. No ceramides or soybean extract. Best as a booster rather than standalone product.
Comparison with competitors
SIDE-BY-SIDEStorage & shelf life
12 MONTHS12 months after opening
Store in a cool, dry place away from direct sunlight. Keep the cap tightly closed after each use to preserve active ingredients.
Glass bottle with dropper dispenser for controlled, hygienic application
Yes — 50ml is under the 100ml TSA carry-on limit. Glass bottle requires careful packing.
Frequently asked questions
FAQYes. This ampoule is considered safe during pregnancy and breastfeeding. It contains no retinoids, salicylic acid, hydroquinone, chemical sunscreens, or any other ingredients flagged as unsafe for pregnant or nursing individuals. The key actives — panthenol, ceramides, glycerin, soybean extract, and hyaluronic acid — are all well-established as safe for use during pregnancy. As always, consult your healthcare provider if you have specific concerns.
Not entirely. While many of the core ingredients (panthenol, glycerin, sodium hyaluronate) are fungal acne safe, the formula contains several potential malassezia triggers: stearic acid, caprylic/capric triglyceride, polyglyceryl-10 stearate, sorbitan olivate, and glyceryl stearate. If you have confirmed fungal acne or are very prone to it, consider alternatives like the Round Lab 1025 Dokdo Ampoule or the Pine Calming Cica Ampoule, which are fungal acne safe according to SkinSort.
Yes, this ampoule is an excellent companion to active ingredients. Panthenol and ceramides help buffer irritation caused by retinol, AHAs, BHAs, and vitamin C. Apply your actives first (such as retinol or vitamin C serum), wait a few minutes, then apply the Soybean Panthenol Ampoule to soothe and protect the skin barrier. This layering approach helps you get the benefits of potent actives while minimizing dryness, redness, and irritation.
This ampoule is best suited for dry, sensitive, and combination skin types. It excels at repairing damaged skin barriers and providing deep hydration without heaviness. It's particularly ideal for those who have over-exfoliated, used too many actives, or have naturally thin and reactive skin. Oily skin types can also benefit but should apply a single thin layer. It's clinically certified as non-irritating, making it one of the gentlest barrier-repair options available.
Immediate hydration and skin softening are noticeable from the first application. Barrier repair and reduced transepidermal water loss (31.08% reduction) are clinically demonstrated within 2 weeks of consistent use. Texture improvements typically appear by weeks 3–4, while the anti-wrinkle benefits from adenosine require at least 6 weeks of continued use. For best results, use twice daily (AM and PM) without interruption.
Apply after cleansing and toning, in the ampoule/serum step of your routine (Step 4). The order is: Cleanser → Toner → Essence (optional) → This Ampoule → Moisturizer → Sunscreen (AM). If using actives like retinol or vitamin C, apply those before this ampoule. The brand also suggests it can be used as the last step, applied like a barrier-sealing layer over other products.
This ampoule has a low comedogenic rating of 1 out of 5. It does not contain heavy oils, mineral oil, or highly comedogenic ingredients at significant concentrations. The key actives (panthenol: comedogenic rating 0, glycerin: comedogenic rating 0) are non-pore-clogging. Cetearyl alcohol has a comedogenic rating of 2 but is present in a small amount as a texture agent. For most people, this product should not cause breakouts or clogged pores.
The Period After Opening (PAO) is 12 months. Once opened, use within one year for optimal efficacy. Store in a cool, dry place away from direct sunlight and high temperatures. Keep the dropper cap tightly sealed after each use to prevent contamination and oxidation of the active ingredients. The 50ml bottle typically lasts 6–8 weeks with twice-daily use.
Verdict: The Round Lab Soybean Panthenol Ampoule is an outstanding barrier-repair ampoule that delivers clinically proven hydration results. Its unique combination of nano niosome panthenol, Jeongseon black soybean extract, and a skin-identical ceramide-cholesterol-fatty acid complex sets it apart from competitors that rely on panthenol alone. The fragrance-free, non-irritating formula makes it a safe choice for sensitive and compromised skin. The only drawbacks are its small 50ml size and the presence of several fungal acne triggers. If your skin is dry, damaged, or in need of serious barrier support, this ampoule is one of the best K-beauty options available today.
Product Overview
Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.
Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.
Quick Product Notes
Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging «promises» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.
We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.
Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.
Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you
Notable Effects & Ingredients
Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.
We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.
A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.
One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!
Ingredients Related to Skin Types
Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.
EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.
Ingredient Safety Breakdown
Product ingredient list
| EWG | CIR | Ingredient Name & Cosmetic Functions | Notes |
|---|---|---|---|
| 1 |
Water
Solvent, Skin Conditioning
|
|
|
| 2 |
Glycerin
Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant, Skin Conditioning
|
Promotes Wound Healing
Hydrating
|
|
| 1 |
Dipropylene Glycol
Fragrance, Solvent, Viscosity Decreasing Agent, Masking, Viscosity Controlling
|
|
|
| 1 |
1,2-Hexanediol
Solvent, Skin Conditioning
|
Hydrating
|
|
| 0 |
Glycine Max Seed Extract
Skin Conditioning, Skin Protecting
|
|





