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Superoxide Dismutase Saccharide Mist

Superoxide Dismutase Saccharide Mist

Product Description

Product overview

Made in Various INTERNATIONAL

A cutting-edge dermal treatment mist featuring 1% Superoxide Dismutase enzyme for powerful antioxidant protection against environmental stressors, water loss, and visible inflammation. This turquoise-colored mist delivers advanced anti-aging defense in a refreshing spray format.

Alcohol-Free Fragrance-Free Vegan Cruelty-Free 1% Superoxide Dismutase pH 6.0-7.0 240ml Large Format
Pregnancy
Caution
Fungal Acne
Caution
Comedogenic
1/5
Size
240ml
Price
$52 USD
pH Level
6.0-7.0
Key Active
SOD 1%
PAO
12M
Real reviews · YouTube Shorts
Why it's different

Antioxidant Protection

1% Superoxide Dismutase neutralizes superoxide radicals, the most common free radicals that cause inflammation and premature aging.

01

Texture & feel

SENSORY
Consistency
Lightweight Mist
Scent
Fragrance-Free
Absorption
30-60 seconds
Finish
Dewy

Antioxidant Protection

1% Superoxide Dismutase neutralizes superoxide radicals, the most common free radicals that cause inflammation and premature aging.

Malachite Mineral Complex

Copper-rich malachite extract provides additional antioxidant support and gives the mist its distinctive turquoise color.

Marine Hydration

Pseudoalteromonas Exopolysaccharides offer hyaluronic acid-like hydration with immediate and long-lasting moisture retention.

Anti-Inflammatory

Purified North American Four O'Clock Flower (Mirabilis Jalapa) reduces visible inflammation and soothes reactive skin.

02

Safety & compatibility

SAFE
Pregnancy & Breastfeeding

Contains Sodium Salicylate (salicylate). While topical use in low concentrations is generally considered low-risk, consult your healthcare provider before use during pregnancy or breastfeeding.

Fungal Acne (Malassezia)

Contains PEG-40 Hydrogenated Castor Oil which may potentially feed malassezia. Patch test recommended for those prone to fungal acne.

Retinol Compatible

Safe to use with retinoids. The soothing properties may actually help calm retinol-induced irritation.

Vitamin C Compatible

Can be used with Vitamin C serums. Apply mist first, let absorb, then layer Vitamin C products.

AHA/BHA Compatible

Works well with chemical exfoliants. The mist can help soothe skin post-exfoliation.

Sensitive Skin Note

The formula is designed to be gentle and soothing. Some users report a slight tingling sensation on sensitized or broken skin. Patch test recommended.

03

Ingredient breakdown

INGREDIENTS

Superoxide Dismutase 1%Proven

A powerful antioxidant enzyme naturally found in the body that neutralizes superoxide radicals—one of the most damaging free radicals responsible for inflammation and premature aging. Unlike non-enzymatic antioxidants, SOD regenerates itself during the neutralization process.

  • Mechanism: Converts superoxide radicals into molecular oxygen and hydrogen peroxide
  • Source: Yeast-derived from grape skin for optimal stability and bioavailability
  • Research: Studies show 1,100% increase in cell viability under UVB exposure when treated with SOD
Self-regenerating antioxidant that provides continuous protection unlike single-use antioxidants like Vitamin E.

Malachite ExtractPromising

A mineral extract from malachite stone, rich in copper which plays a role in skin formation and regeneration. Provides additional antioxidant protection and scavenges free radicals. Responsible for the product's distinctive turquoise color.

  • Copper Content: More than 50% copper by composition
  • Function: Supports collagen synthesis and provides antioxidant defense

Pseudoalteromonas ExopolysaccharidesProven

A biotechnological marine polysaccharide alternative to hyaluronic acid. Rich in glucuronic acid (the same monosaccharide found in HA) for comparable hydration benefits with improved skin feel.

  • Benefit: Immediate and long-lasting hydration
  • Effect: Reduces appearance of fine lines and skin roughness
  • Source: Sustainable marine bio-fermentation

Mirabilis Jalapa ExtractPromising

Purified extract from the North American Four O'Clock Flower, an Aztec plant studied for its anti-inflammatory properties. Targets pro-inflammatory mediators to reduce visible signs of inflammation and redness.

  • Action: Reduces pro-inflammatory mediators
  • Benefit: Calms reactive and sensitized skin

Polypodium Vulgare Rhizome ExtractPromising

A fern extract known as Polypody with film-forming, moisturizing, antioxidant, and skin-repairing properties.

  • Properties: Antioxidant and film-forming for barrier protection
  • Effect: Helps repair and moisturize compromised skin

ArginineProven

An essential amino acid that is a primary building block of hair keratin and skin collagen. Acts as a natural moisturizing factor and may help speed wound healing.

  • Function: Natural moisturizing factor (NMF)
  • Benefit: Skin conditioning and hydration support

22 ingredients

Aqua (Water), Superoxide Dismutase, Malachite Extract, Pseudoalteromonas Exopolysaccharides, Mirabilis Jalapa Extract, Polypodium Vulgare Rhizome Extract, Cetraria Islandica Thallus Extract, Sphagnum Magellanicum Extract, Arginine, Propanediol, Glycerin, Pentylene Glycol, Butylene Glycol, Sodium Salicylate, Gellan Gum, Sodium Chloride, PPG-26-Buteth-26, PEG-40 Hydrogenated Castor Oil, Citric Acid, Tromethamine, Phenoxyethanol, Chlorphenesin.

FREE FROM: Alcohol (Denat.), Fragrance/Parfum, Parabens, Sulfates, Silicones, Essential Oils, Artificial Colors
04

Where it fits in your routine

ROUTINE
1
Cleanser
2
SDSM2 Mist
3
Toner
4
Serum
5
Moisturizer
6
Sunscreen (AM)

Apply immediately after cleansing as the first step in your routine. Can also be used throughout the day for a hydration boost or after makeup application. When using with NIOD regimen, apply after LVCE and/or SS, but before CAIS3.

05

How to use

HOW TO USE
1

Cleanse Your Skin

Start with a clean, freshly washed face. Pat dry or leave slightly damp for enhanced absorption.

2

Mist Generously

Hold the bottle 6-8 inches from your face. Spray 2-3 pumps across face and neck with eyes closed. Can also be applied to body areas.

3

Pat or Let Absorb

Gently pat the mist into skin or allow it to air dry for 30-60 seconds. The slight tackiness will subside.

4

Continue Routine

Follow with your toner, serums, moisturizer, and sunscreen (AM). Use morning and evening for best results.

06

Who is it for?

WHO

Perfect for you if:

  • You want antioxidant protection beyond Vitamin C
  • Your skin is exposed to pollution and environmental stressors
  • You experience redness or inflammation
  • You're looking for preventative anti-aging care
  • You want a hydrating mist with active benefits
  • You use tretinoin and need soothing support
  • You prefer fragrance-free formulas

Consider alternatives if:

  • You have severe fungal acne (contains castor oil derivative)
  • You're pregnant and want to avoid salicylates completely
  • You prefer a completely matte finish
  • You want a very fine, ultra-lightweight mist
  • Budget is very limited (consider The Ordinary EUK 134)
  • You prefer scented products
07

Skin type compatibility

SKIN TYPES
Oily Skin
Good

Lightweight formula works well for most oily skin types. Some users report slight heaviness from castor oil derivative—let product fully absorb before layering.

Dry Skin
Excellent

Marine polysaccharides and humectants provide excellent hydration. Follow with moisturizer for optimal results.

Combination
Excellent

Balances well across different face zones. Hydrates dry areas without overwhelming oily T-zone.

Sensitive
Excellent

Fragrance-free with anti-inflammatory ingredients. The soothing Four O'Clock Flower extract helps calm reactive skin. May tingle briefly on compromised skin.

Acne-Prone
Good

Low comedogenic rating (1/5). However, contains castor oil derivative which may affect some fungal acne sufferers. Patch test recommended.

Mature Skin
Excellent

Ideal for preventative anti-aging. SOD targets the oxidative stress that accelerates aging. Excellent daily protection.

08

Results timeline

MONTH 2-3+
Immediate

Refreshing Hydration

Instant cooling sensation and hydration boost. Skin feels refreshed and plumped. The turquoise mist provides a pleasant sensory experience.

95% noticed
Week 1-2

Calmer, Less Reactive Skin

Reduction in daily redness and irritation. Skin appears more balanced and comfortable. Those using tretinoin may notice reduced sensitization.

78% noticed
Week 4-6

Improved Skin Resilience

Enhanced defense against environmental stressors. Skin maintains hydration better throughout the day. Overall skin quality appears improved.

65% noticed
Month 2-3+

Preventative Benefits

Long-term antioxidant protection helps delay visible signs of aging. Consistent users report maintained skin quality and continued protection against oxidative stress.

70% noticed
09

Ratings by platform

200+ REVIEWS
NIOD Official / Deciem
4.3
Rating
87%
Love It
Main complaint: Spray mechanism can be stiff and hard to push down initially
Cult Beauty
4.2
Rating
150+
Reviews
Main complaint: Effects are subtle and hard to notice for some users
Space NK
4.5
Rating
50+
Reviews
Main complaint: Premium price point, though large bottle offers good value
Beauty Bloggers
3.9
Avg Rating
High
Repurchase
Main complaint: Mist not as fine as some prefer; some find texture slightly heavy
10

Pros & cons

BALANCED

Praised

  • Effective antioxidant protection with 1% SOD
  • Soothing and calming for reactive skin
  • Large 240ml bottle lasts for months
  • Fragrance-free and alcohol-free
  • Works well with tretinoin routines
  • Can be used on face and body
  • Beautiful turquoise color from malachite
  • Good value per ml for the quality
  • Hydrating without feeling heavy for most

Criticized

  • Spray pump can be stiff and difficult initially
  • Results are preventative—not immediately visible
  • Some oily skin types find texture too heavy
  • Contains castor oil derivative (fungal acne concern)
  • Initial price point feels expensive
  • Mist is not ultra-fine like some competitors
  • Clear bottle not ideal for antioxidant stability
  • May tingle on sensitized or broken skin
11

Budget-friendly alternatives (dupes)

DUPES
85% Match
EUK 134 0.1%
$11.00
Budget Pick

Uses EUK-134, a mimetic of Superoxide Dismutase that provides similar antioxidant benefits. Oil-based serum format (not a mist). Smaller 30ml size but much lower price per ml. Cannot be mixed with Vitamin C.

65% Match
Fundamental Ampule Mist
$26.00
Similar Price

Hydrating mist with peptides and hyaluronic acid. Similar soothing benefits but lacks the specific SOD antioxidant. Better for pure hydration focus rather than antioxidant protection.

55% Match
Facial Spray With Aloe, Herbs and Rosewater
$7.00
Budget Pick

Popular hydrating mist with aloe and herbs. Very affordable but lacks sophisticated antioxidant technology. Good for basic hydration refresh but not comparable actives.

70% Match
Freshly Cosmetics Superoxide Dismutase Face Mist
$32.00
Similar Price

Contains actual Superoxide Dismutase like NIOD. Similar concept in mist format. Different supporting ingredients but closest true dupe available.

12

Comparison with competitors

SIDE-BY-SIDE

NIOD SDEM3 (Newer Version)

Key Ingredient SOD3 (Newest Form)
Size 50ml / 120ml
Price per ml $0.48/ml (50ml)
Format Enzyme Mist
Technology SOD3 works between cells
Beauty Elixir Face Mist
Key Ingredient Grape Extract + Essential Oils
Size 100ml
Price per ml $0.49/ml
Format Beauty Mist
Fragrance Contains Alcohol + Fragrance
EUK 134 0.1%
Key Ingredient 0.1% EUK-134 (SOD Mimetic)
Size 30ml
Price per ml $0.37/ml
Format Oil Serum (Not Mist)
Note Cannot mix with Vitamin C
13

Storage & shelf life

12 MONTHS
Period After Opening (PAO)

12 months after opening. A small amount of precipitate may appear over time—this is normal and will re-dissolve with a gentle shake.

Storage

Store in a cool, dry place away from direct sunlight. The clear bottle means light exposure should be minimized. Consider storing in a cabinet or drawer.

Packaging

Clear plastic spray bottle with pump mechanism. The pump may be stiff initially but loosens with use.

Travel Friendly

No, 240ml exceeds carry-on liquid limits (100ml). Consider decanting into a smaller spray bottle for travel.

13

Frequently asked questions

FAQ

SDSM2 contains Sodium Salicylate, a salicylate compound. While topical salicylic acid in low concentrations is generally considered low-risk during pregnancy, some healthcare providers advise caution with any salicylate-containing products. The concentration in SDSM2 is low and used as a preservative rather than an active, but if you want to be completely cautious, consult your doctor before use during pregnancy or breastfeeding.

SDSM2 contains PEG-40 Hydrogenated Castor Oil, which is flagged by some fungal acne resources as potentially feeding malassezia. If you're prone to fungal acne, patch test on a small area first. Some users with fungal acne report no issues, while others prefer to avoid it. Consider The Ordinary EUK 134 as an alternative if fungal acne is a major concern.

Yes! SDSM2 is compatible with most active ingredients including retinol, Vitamin C, and AHA/BHA acids. In fact, the soothing and anti-inflammatory properties make it particularly helpful when using tretinoin or other potentially irritating actives. Apply SDSM2 first after cleansing, let it absorb, then layer your other products. Unlike The Ordinary EUK 134, SDSM2 can be safely used with Vitamin C.

SDSM2 works well for most skin types but is particularly excellent for sensitive, dry, combination, and mature skin. Those with oily skin may find it slightly heavy due to the castor oil derivative—if so, use sparingly and allow full absorption before layering. It's ideal for anyone wanting preventative anti-aging, antioxidant protection, or soothing support for reactive skin.

You'll feel immediate hydration and refreshment from the first use. Soothing benefits for reactive skin typically appear within 1-2 weeks. However, SDSM2 is primarily a preventative antioxidant product—its main benefits (protection against environmental damage and delayed signs of aging) are long-term and cumulative. Think of it as daily protection rather than a quick-fix treatment.

Apply SDSM2 as the first step after cleansing, morning and evening. Mist onto clean skin, let absorb for 30-60 seconds, then continue with your toner, serums, moisturizer, and sunscreen (AM). It can also be used throughout the day for a hydration boost, over makeup, or on body areas. When using other NIOD products, apply after LVCE and/or SS, but before CAIS3.

SDSM2 has a low comedogenic rating of 1/5. The water-based formula with marine polysaccharides is unlikely to clog pores for most users. However, it does contain PEG-40 Hydrogenated Castor Oil which some acne-prone individuals may want to patch test. Overall, the formula is designed to be non-comedogenic and suitable for acne-prone skin.

SDSM2 has a Period After Opening (PAO) of 12 months. The 240ml bottle typically lasts 3-6 months with twice-daily use on face and neck, depending on how generously you apply. Over time, you may notice a small amount of precipitate—this is normal for the saturated SOD formula and will re-dissolve with a gentle shake. Store away from direct sunlight to maximize shelf life.

— Skincarisma verdict
4.3 / 5 ★★★★☆

Verdict: NIOD Superoxide Dismutase Saccharide Mist (SDSM2) is an innovative, science-backed treatment mist that delivers serious antioxidant protection in an enjoyable format. The 1% Superoxide Dismutase concentration offers powerful defense against environmental stressors and oxidative damage that accelerates aging. While results are preventative rather than immediately visible, consistent users appreciate the soothing benefits, especially alongside tretinoin. The 240ml bottle provides excellent value despite the premium price point. Best suited for those seeking advanced anti-aging protection, sensitive skin relief, or a sophisticated upgrade from basic hydrating mists. A standout product in the NIOD lineup.

Product Overview

question
lightbulb What are Quick Product Notes?

Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.

muscle Pro Tip Alert!

Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.

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Quick Product Notes

Click on icons for more information
question
lightbulb What are Notable Effects & Ingredients?

Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging «promises» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.

We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.

muscle Pro Tip Alert!

Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.

Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you

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Notable Effects & Ingredients

anti-aging Anti-Aging from 2 ingredient(s):
Superoxide Dismutase Citric Acid
brightening Brightening from 2 ingredient(s):
Glycerin Citric Acid
wound Promotes Wound Healing from 3 ingredient(s):
Arginine Glycerin Citric Acid
question
lightbulb What are Ingredients Related to Skin Type?

Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.

We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.

muscle Pro Tip Alert!

A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.

One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!

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Ingredients Related to Skin Types

Click on icons for more information
dry-skin Dry Skin
2
oily-skin Oily/Acne-Prone Skin
1
sensitive-skin Sensitive Skin
question
lightbulb What is the Ingredient Safety Breakdown?

Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.

muscle Pro Tip Alert!

EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.

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Ingredient Safety Breakdown

EWG Health Ratings
Low risk
Medium risk
High risk
Unknown risk
59% 9% 31%

Product ingredient list

Showing first 5 of 22 ingredients
EWG CIR Ingredient Name & Cosmetic Functions Notes
1 Unknown
Water
Solvent, Skin Conditioning
1 Unknown
Superoxide Dismutase
Reducing, Skin Conditioning, Antioxidant
anti-aging Anti-Aging
1 Unknown
Malachite Extract
Antioxidant
0 Unknown
Pseudoalteromonas Exopolysaccharides
Skin Conditioning
0 Unknown
Mirabilis Jalapa Extract
Skin Conditioning, Skin Protecting
VIEW ALL INGREDIENTS