Toleriane Sensitive Fluide
Toleriane Sensitive Fluide
Product Description
Product overview
An intensely soothing, preservative-free night cream formulated with Neurosensine and La Roche-Posay Thermal Spring Water to hydrate, comfort, and restore ultra-sensitive and allergy-prone skin overnight. Features innovative airless pump packaging with anti-contamination valves.
Neurosensine Technology
Patented dipeptide that signals skin cells to "relax," reducing sensitivity and discomfort instantly.
Texture & feel
SENSORYNeurosensine Technology
Patented dipeptide that signals skin cells to "relax," reducing sensitivity and discomfort instantly.
Thermal Spring Water
Selenium-rich water sourced from La Roche-Posay, France with proven soothing and antioxidant properties.
Barrier Repair
Niacinamide and shea butter work together to strengthen and restore the skin's protective moisture barrier.
Airless Pump
Anti-contamination valves prevent air and bacteria from entering, eliminating the need for preservatives.
Safety & compatibility
SAFEContains no retinoids, salicylic acid, hydroquinone, or chemical sunscreens. All ingredients are considered safe during pregnancy and nursing.
Contains Shea Butter, Polysorbate 20, and Sphingomonas Ferment Extract which may feed Malassezia yeast. Patch test first if prone to fungal acne.
Rated 1/5. Formula is oil-free and non-comedogenic. Main emollients (squalane, shea butter) have minimal pore-clogging potential.
Contains niacinamide which some individuals may find irritating. Start with alternate nights if you have very reactive skin.
Ingredient breakdown
INGREDIENTSNeurosensine (Acetyl Dipeptide-1 Cetyl Ester) 0.05-0.25%Proven
A patented soothing dipeptide that acts as a "messenger of tranquility." It signals skin nerve cells to release met-enkephalin, providing instant relief from irritation and discomfort.
- Mechanism: Stimulates opioid receptors in skin to reduce sensitivity signals
- Clinical: Shown to decrease skin irritation from heat, chemical, and mechanical stress
Glycerin 5-10%Proven
A powerful humectant that draws moisture from the environment into the skin. Also helps maintain the skin's lipid barrier in optimal condition.
- Efficacy: Effective from 3%, with increased benefits at higher concentrations up to 20%
- Rating: Comedogenic 0, Irritancy 0 - suitable for all skin types
Squalane 2-5%Proven
A skin-identical emollient that mimics our natural sebum. Provides excellent moisturization without greasiness, helping prevent transepidermal water loss.
- Source: Typically plant-derived (olive or sugarcane)
- Rating: Comedogenic 1 - very low pore-clogging potential
Niacinamide (Vitamin B3) 2%Proven
A multi-functional superstar that strengthens the skin barrier, calms inflammation, fades discoloration, and regulates sebum production.
- Benefits: Anti-aging, brightening, barrier repair, anti-inflammatory
- Concentration: Effective at 2-5% for barrier support and soothing
Shea Butter 2-4%Proven
Sustainably sourced from Burkina Faso. Rich in vitamins A, E, and F plus antioxidants. Helps restore the skin's hydrolipidic film and provides deep nourishment.
- Benefits: Emollient, anti-inflammatory, antioxidant, skin barrier restoration
- Source: Sustainably sourced from Burkina Faso
Allantoin 0.1-0.5%Proven
A gentle soothing agent that calms irritation, promotes wound healing, and softens skin. Found naturally in comfrey plant but synthetically produced for purity.
- Rating: Comedogenic 0, Irritancy 0
- Benefits: Soothing, skin-softening, promotes cell regeneration
Tocopherol (Vitamin E) 0.1-0.5%Proven
A potent antioxidant that protects skin from free radical damage and environmental stressors. Works synergistically with other antioxidants in the formula.
- Benefits: Antioxidant protection, photoprotection against UVB
- Synergy: Enhanced effectiveness when combined with Vitamin C
24 ingredients
Aqua/Water/Eau, Glycerin, Butylene Glycol, Propanediol, Butyrospermum Parkii Butter/Shea Butter, Pentylene Glycol, Squalane, Niacinamide, Ammonium Polyacryloyldimethyl Taurate, Pyridoxine HCl, Polysorbate 20, Zea Mays Starch/Corn Starch, Salvia Miltiorrhiza Root Extract, Allantoin, Glyceryl Acrylate/Acrylic Acid Copolymer, Sodium Hydroxide, Sphingomonas Ferment Extract, Hydroxyacetophenone, Caprylyl Glycol, Citric Acid, Trisodium Ethylenediamine Disuccinate, Acetyl Dipeptide-1 Cetyl Ester, Xanthan Gum, Tocopherol
Where it fits in your routine
ROUTINEApply as the final step of your PM routine. Can be layered over serums and treatments. For very dry skin, seal with an occlusive like Vaseline.
How to use
HOW TO USECleanse
Start with clean, dry skin. Use a gentle cleanser like Toleriane Caring Wash to remove makeup and impurities without stripping moisture.
Apply Serums (Optional)
If using serums or treatments (retinol, vitamin C), apply them first and let absorb completely before moisturizer.
Dispense Product
Pump 1-2 pumps into your palm. The airless pump dispenses the perfect amount and keeps the formula fresh.
Apply in Circular Motions
Gently massage onto face, neck, and eye area in upward circular motions. Allow to absorb before going to bed.
Who is it for?
WHOPerfect for you if:
- You have sensitive, reactive, or allergy-prone skin
- You experience redness, tightness, or discomfort
- You have a damaged skin barrier from over-exfoliation
- You're pregnant or breastfeeding and need safe skincare
- You prefer minimalist, fragrance-free formulas
- You have rosacea or eczema-prone skin
- You use retinoids and need a soothing buffer
Consider alternatives if:
- You have fungal acne (malassezia folliculitis)
- You prefer very rich, heavy night creams
- You want anti-aging actives like retinol in your moisturizer
- You prefer larger bottle sizes for better value
- You have very oily skin that doesn't need extra moisture
Skin type compatibility
SKIN TYPESSpecifically formulated for ultra-sensitive and allergy-prone skin. Neurosensine provides instant soothing relief.
Shea butter and squalane provide deep nourishment. Glycerin draws moisture in for lasting hydration.
Lightweight gel-cream texture absorbs well. May be sufficient alone or use less product on oily zones.
Oil-free and non-comedogenic. Light texture absorbs quickly without adding shine. Niacinamide helps regulate sebum.
Non-comedogenic with low pore-clogging risk. Niacinamide helps calm breakouts. Not fungal acne safe.
Results timeline
8+ WEEKSInstant Comfort
Neurosensine provides immediate soothing relief. Skin feels calmed, hydrated, and less tight or irritated.
95% noticedImproved Hydration
Up to 48 hours of hydration. Skin feels softer, smoother, and more comfortable throughout the day.
88% noticedBarrier Restoration
Niacinamide and shea butter strengthen the skin barrier. Reduced reactivity and sensitivity to triggers.
82% noticedVisible Improvement
Reduced redness, improved skin texture, and overall healthier-looking complexion. Less frequent flare-ups.
76% noticedRatings by platform
750+ REVIEWSPros & cons
BALANCEDPraised
- Instantly soothes sensitive, reactive skin
- Fragrance-free and preservative-free formula
- Lightweight gel-cream absorbs quickly
- Innovative airless pump prevents contamination
- Works beautifully with retinoids and actives
- Pregnancy and breastfeeding safe
- Non-greasy finish suitable for all seasons
- Helps repair damaged skin barrier
Criticized
- Small bottle size (40ml) for the price
- Not moisturizing enough for very dry skin
- Some users find texture too thin for a night cream
- Niacinamide may irritate extremely sensitive individuals
- Not fungal acne safe
- Minimal anti-aging ingredients
Budget-friendly alternatives (dupes)
DUPESSimilar niacinamide-based formula with ceramides for barrier repair. Slightly lighter texture. Contains hyaluronic acid instead of Neurosensine.
Fragrance-free, lightweight formula with hyaluronic acid. Lacks soothing peptides and shea butter but excellent for sensitive skin on a budget.
German pharmacy alternative with SymSitive technology for sensitive skin. Minimal ingredients but lacks niacinamide and antioxidants.
Contains niacinamide, peptides, and ceramides like the original. Richer texture. Good for dry skin but not specifically for ultra-sensitive.
Comparison with competitors
SIDE-BY-SIDEStorage & shelf life
12 MONTHS12 months after opening. Airless packaging extends freshness by preventing contamination.
Store at room temperature in a cool, dry place away from direct sunlight. No refrigeration needed.
Innovative airless pump with anti-contamination valves. Twist cap to open/close. Dispenses product from bottom up.
Yes, under 100ml. TSA-approved carry-on size. Airless pump works reliably during air travel.
Frequently asked questions
FAQYes, this product is considered safe during pregnancy and breastfeeding. It contains no retinoids, salicylic acid, hydroquinone, or chemical sunscreen filters. All ingredients are gentle and suitable for use during pregnancy. The Toleriane line is often recommended by dermatologists as pregnancy-safe skincare.
This product is NOT fully fungal acne safe. It contains Shea Butter (fatty acids that can feed Malassezia), Polysorbate 20 (an emulsifier that may be problematic), and Sphingomonas Ferment Extract (a fermented ingredient). If you have fungal acne, consider alternatives like La Roche-Posay Toleriane Sensitive Fluide which has a simpler formula.
Yes! This is an excellent companion product for active treatments. Apply your retinol, vitamin C, or chemical exfoliant first, let absorb, then apply this cream to lock in moisture and soothe any irritation. The Neurosensine helps buffer potential irritation from actives. Many users specifically use this to "sandwich" tretinoin.
This cream is specifically designed for ultra-sensitive, reactive, and allergy-prone skin. It's excellent for those with rosacea, eczema-prone skin, damaged skin barriers, or anyone who experiences redness, tightness, and discomfort. It also works well for dry to normal skin types. Those with very oily skin may find it slightly rich.
You'll feel instant soothing comfort from the first application thanks to Neurosensine. Improved hydration is noticeable within 1-2 weeks. Full barrier restoration and reduced sensitivity typically takes 4-8 weeks of consistent nightly use. For best results, pair with other Toleriane products and avoid irritating ingredients.
Apply as the final step of your PM routine after cleansing, toning, serums, and treatments. The order is: Cleanser → Toner → Essence → Serum → Treatment (retinol, acids) → This Moisturizer → Occlusive (optional, for very dry skin). It's designed for evening use only.
This product has a comedogenic rating of 1/5, meaning it has very low pore-clogging potential. It's oil-free and non-comedogenic. The main emollients (squalane rated 1, glycerin rated 0, shea butter rated 0-2) are generally safe for acne-prone skin. However, everyone's skin is different, so patch testing is always recommended.
The product has a PAO (Period After Opening) of 12 months. The innovative airless pump packaging with anti-contamination valves helps extend freshness by preventing air and bacteria from entering the container. This allows for the preservative-free formula while maintaining product integrity.
Verdict: La Roche-Posay Toleriane Dermallergo Night Moisturizer is an excellent choice for anyone with sensitive, reactive, or allergy-prone skin seeking a gentle yet effective night cream. The patented Neurosensine technology provides instant soothing relief, while niacinamide and shea butter work to strengthen the skin barrier over time. The preservative-free, fragrance-free formula in innovative airless packaging makes it ideal for the most delicate skin types. The main drawbacks are the small bottle size for the price and the fact that it's not fungal acne safe. For ultra-sensitive skin looking for nighttime comfort and hydration, this is one of the best options on the market.
Browse related
Product Overview
Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.
Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.
Quick Product Notes
Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging «promises» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.
We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.
Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.
Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you
Notable Effects & Ingredients
Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.
We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.
A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.
One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!
Ingredients Related to Skin Types
Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.
EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.
Ingredient Safety Breakdown
Product ingredient list
| EWG | CIR | Ingredient Name & Cosmetic Functions | Notes |
|---|---|---|---|
| 1 |
Water
Solvent, Skin Conditioning
|
|
|
| 1 |
Caprylic/Capric Triglyceride
Solvent, Skin Conditioning, Masking, Perfuming, Emollient
|
|
|
| 2 |
Glycerin
Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant, Skin Conditioning
|
Promotes Wound Healing
Hydrating
|
|
| 1 |
Propanediol
Solvent, Viscosity Controlling, Viscosity Decreasing Agent
|
|
|
| 1 |
Pentylene Glycol
Solvent, Skin Conditioning
|
|








