Up The Anti
Up The Anti
Product Description
A peptide-rich anti-aging night cream with niacinamide, botanical hyaluronic acid, and a trio of collagen-boosting peptides. Formulated with natural and organic ingredients to reduce fine lines, firm skin, and lock in overnight hydration while you sleep.
β¨ Texture & Feel
Triple Peptide Complex
Contains Palmitoyl Tetrapeptide-7, Tripeptide-1, and Tripeptide-5 to stimulate collagen production and improve skin elasticity overnight.
Niacinamide (Vitamin B3)
Boosts ceramide, elastin, and keratin production to strengthen the skin barrier, smooth texture, and fade hyperpigmentation.
Botanical Hyaluronic Acid
Plant-derived HA draws in and locks moisture into the skin, plumping fine lines and leaving skin hydrated through the night.
Organic Botanicals
Organic green tea, gotu kola, aloe, and dandelion extract deliver antioxidants and soothe skin while it repairs overnight.
π‘οΈ Safety & Compatibility
Contains lactic acid (sodium lactate) at a low concentration. No retinoids, salicylic acid, or hydroquinone. Consult your OB/GYN before use during pregnancy.
Not fungal acne safe. Contains isopropyl palmitate (ester), polysorbate 20, and several fatty acids/oils that can feed malassezia yeast.
Free from parabens, sulfates, synthetic fragrances, dyes, formaldehyde, and mineral oil. Dermatologist approved and clinically tested.
Certified cruelty-free. Made with natural and organic ingredients. Small batch processed in the USA with responsibly sourced ingredients.
No oxybenzone, octinoxate, or chemical UV filters. Safe for marine environments.
Contains plant-derived oils (safflower, sunflower, jojoba) and shea butter. Patch test if you have known nut or botanical allergies.
π¬ Ingredient Breakdown
𧬠Niacinamide (Vitamin B3) ~2-5% Proven
A powerhouse form of vitamin B3 that increases ceramide, elastin, and keratin production. Firms and smooths skin while helping to fade dark spots and uneven tone.
- Clinical Evidence: Studies show 2-5% niacinamide significantly reduces wrinkles, blotchiness, and redness after 12 weeks of use.
- Barrier Support: Strengthens the lipid barrier by boosting ceramide synthesis, improving moisture retention over time.
- Compatibility: Plays well with peptides and hyaluronic acid. Safe with most other actives.
π§ Botanical Hyaluronic Acid ~0.5-1% Proven
A plant-derived form of hyaluronic acid that can hold up to 1,000 times its weight in water. Draws moisture into the skin, plumping fine lines and delivering deep hydration.
- Hydration: HA significantly reduces skin dryness and improves elasticity with consistent use.
- Anti-Aging: Plumps the skin surface, visibly reducing the appearance of fine lines within weeks.
- Source: Botanical origin (plant-derived fermentation), not animal-sourced.
π§ͺ Palmitoyl Tripeptide-1 & Tripeptide-5 Signal peptides Promising
Signal peptides that mimic the skin's own collagen-building messages. Tripeptide-1 (also known as Matrixyl 3000 component) and Tripeptide-5 stimulate collagen I and III synthesis for firmer, more resilient skin.
- Collagen Boost: In vitro studies show palmitoyl tripeptide-1 can stimulate collagen production comparable to retinol without irritation.
- Synergy: When combined (as in this formula), these peptides work synergistically for enhanced anti-wrinkle results.
- Gentle: Peptides are non-irritating, making them ideal for nighttime repair in sensitive formulas.
π‘οΈ Palmitoyl Tetrapeptide-7 Signal peptide Promising
An anti-inflammatory peptide that reduces the release of interleukin-6 (IL-6), a chemical messenger involved in chronic inflammation and skin aging.
- Anti-Inflammaging: Helps prevent chronic low-grade inflammation that accelerates visible skin aging.
- Clinical Use: Often paired with Palmitoyl Tripeptide-1 in the Matrixyl 3000 complex for combined firming and soothing benefits.
πΏ Centella Asiatica (Gotu Kola) Organic Proven
A time-honored botanical known for wound healing and collagen support. Rich in madecassoside and asiaticoside, it calms irritation and supports skin repair.
- Repair: Stimulates type I collagen synthesis and promotes wound healing at the cellular level.
- Soothing: Clinically shown to reduce redness and inflammation in compromised skin.
π΅ Green Tea Extract Organic Proven
Rich in EGCG polyphenols, organic green tea provides potent antioxidant protection against free radical damage while calming inflammation and supporting skin repair overnight.
- Antioxidant: EGCG is one of the most powerful natural antioxidants studied in dermatology.
- Photo-Protection: May help reduce UV-induced damage when used as part of a complete routine.
41 ingredients
Aqua (Deionized Water), Aloe Barbadensis Leaf Juice (Organic Aloe), Carthamus Tinctorius Seed Oil (Safflower), Glycerin, Glyceryl Stearate, Stearic Acid, Helianthus Annuus Seed Oil (Organic Sunflower), Isopropyl Palmitate, Simmondsia Chinensis Seed Oil (Organic Jojoba), Tocopheryl Acetate (Vitamin E), Butyrospermum Parkii Butter (Shea Butter), Glyceryl Stearate Citrate, Panthenol (Vitamin B5), Sodium Carbomer, Ethylhexylglycerin, Sodium PCA, Sodium Lactate (Lactic Acid), Arginine, Camellia Sinensis Leaf Extract (Organic Green Tea), Caesalpinia Spinosa Gum, Botanical Hyaluronic Acid, Aspartic Acid, Niacinamide (Vitamin B3), Glycine, Alanine, Serine, Valine, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Palmitoyl Tripeptide-5, Isoleucine, Proline, Threonine, Carbomer, Histidine, Phenylalanine, Centella Asiatica Extract (Organic Gotu Kola), Equisetum Arvense Extract (Horsetail), Geranium Maculatum Extract (Wild Geranium), Taraxacum Officinale Extract (Organic Dandelion), Xanthan Gum, Polysorbate 20.
π Where It Fits in Your Routine
Use every evening as the last step of your PM skincare routine (or before a face oil). Pairs well with Eight Saints Night Shift Gel or Seeking C Serum.
π How to Use
Cleanse Your Skin
Start with a clean face. Remove makeup and wash with a gentle cleanser to ensure active ingredients can penetrate effectively.
Apply Serums & Eye Cream
Apply any water-based serums (like vitamin C or hyaluronic acid serums) and eye cream before the night cream.
Apply Up The Anti
Take a pea-sized amount and gently massage evenly onto face and neck using upward strokes. A little goes a long way.
Optional: Seal with Oil
For extra-dry skin, layer a botanical face oil on top to lock in all the active ingredients and boost overnight hydration.
π€ Who Is It For?
β Perfect for you if:
- You want to target fine lines, wrinkles, and loss of firmness
- You prefer natural and organic skincare formulas
- You need a nourishing night cream that hydrates without feeling greasy
- You want peptide-based anti-aging without retinol irritation
- You value cruelty-free, clean beauty brands
- You experience skin dullness and want to wake up with a glow
β Consider alternatives if:
- You have fungal acne (contains isopropyl palmitate and polysorbate 20)
- You prefer completely fragrance-free products (has a natural green tea scent)
- You want a lightweight gel texture for very oily skin
- You need a daytime moisturizer with SPF protection
- You are looking for high-concentration retinol or glycolic acid
π― Skin Type Compatibility
Rich, nourishing formula with shea butter, safflower oil, and hyaluronic acid delivers deep overnight hydration for parched skin.
Ideal balance of hydration and anti-aging actives. Absorbs well without feeling too heavy or too light.
Works well for nighttime use when oil production is lower. Apply a thinner layer on the T-zone for best results.
May feel too rich for very oily skin. Contains oils and shea butter. Consider the lighter Night Shift gel instead.
No harsh actives, paraben-free, and dermatologist approved. Contains soothing aloe and gotu kola. Patch test first if very reactive.
Purpose-built for aging concerns. Triple peptide complex + niacinamide tackle wrinkles, firmness, and dullness simultaneously.
π Results Timeline
Immediate Softness & Hydration
Skin feels noticeably softer and more hydrated upon waking. The botanical hyaluronic acid begins drawing moisture into the skin immediately.
100% noticed improved hydration (clinical study)Improved Texture & Glow
Skin starts looking brighter and more radiant. Niacinamide begins improving overall skin texture and smoothness. Fine lines appear slightly plumped.
80% reported brighter, more radiant skinVisible Anti-Aging Results
Fine lines appear visibly reduced. Skin feels firmer and more resilient. Smoother, more even-toned complexion. Peptides are actively stimulating collagen production.
80% reported fine lines appeared less harsh (clinical study)Cumulative Firming & Wrinkle Reduction
Continued use enhances collagen synthesis from the triple peptide complex. Wrinkles become less pronounced, skin elasticity improves, and overall radiance is sustained.
Consistent nightly use recommended for best long-term resultsβ Ratings by Platform
βοΈ Pros & Cons
β Praised
- Clinically tested β 5/5 testers felt more hydrated, softer skin after 28 days
- Triple peptide complex offers retinol-like benefits without irritation
- Natural and organic ingredients with transparent labeling
- A little goes a long way β 2 oz jar lasts 3β4 months
- Can be used on face and neck/dΓ©colletΓ©
- Made in USA, small batch, cruelty-free
- Non-greasy absorption despite rich texture
- Contains multiple amino acids that are skin-identical moisturizing factors
β Criticized
- Not fungal acne safe due to isopropyl palmitate and polysorbate 20
- Jar packaging exposes product to air and bacteria
- Natural green tea scent may bother fragrance-sensitive users
- Too rich for very oily skin types
- Peptide concentrations are not disclosed
- Price per oz is higher than some drugstore competitors
π° Budget-Friendly Alternatives (Dupes)
Contains amino acids and hyaluronic acid for barrier support, but lacks the triple peptide complex and niacinamide. Simpler moisturizer without strong anti-aging actives.
Contains peptides, niacinamide, and plant-based ingredients at a lower price. Most popular community-voted alternative. Vegan formula with similar anti-aging targets.
Peptide complex with ceramides and hyaluronic acid. Stronger barrier repair focus with MVE delivery technology. Lacks the natural/organic ingredient profile and botanical antioxidants.
π Comparison with Competitors
Eight Saints Up The Anti
$42.00Olay Regenerist Retinol 24 Night
$28.99CeraVe Skin Renewing Night Cream
$19.99Pacifica Future Youth Super Cream
$18.00π¦ Storage & Shelf Life
12 months after opening
Store in a cool, dry place away from direct sunlight. Keep lid tightly closed between uses to preserve active ingredients.
Glass jar with screw-top lid. Use a clean spatula or spoon to minimize bacterial contamination.
Yes β 2 oz (60 ml) is under the 100 ml TSA carry-on limit.
β Frequently Asked Questions
Use with caution. Up The Anti does not contain retinoids, salicylic acid, or hydroquinone β the most commonly flagged pregnancy ingredients. However, it does contain sodium lactate (lactic acid) at a low concentration. While this is generally considered low-risk, it is always best to consult with your OB/GYN or dermatologist before adding any new skincare product during pregnancy or breastfeeding.
No, Up The Anti is not fungal acne safe. It contains isopropyl palmitate (a fatty acid ester), polysorbate 20, and several plant oils (safflower, sunflower, jojoba) and shea butter β all of which can feed malassezia yeast and potentially trigger fungal acne breakouts. If you are prone to fungal acne, look for an oil-free, FA-safe alternative.
Yes, but with care. Niacinamide pairs well with most actives. If you use retinol, apply it before this cream as a buffer. Vitamin C is best used in the morning (AM) while Up The Anti is for nighttime (PM), so they naturally separate. If using AHA/BHA exfoliants, apply them before this cream and wait a few minutes for absorption. The peptides and HA in this formula are compatible with all common actives.
Up The Anti works best for dry, normal, and mature/aging skin types. Its rich, nourishing formula with shea butter, plant oils, and hyaluronic acid is ideal for skin that needs deep overnight hydration and anti-aging support. Combination skin can also benefit, especially at night. Very oily skin types may find it too heavy β consider Eight Saints Night Shift gel moisturizer as a lighter alternative.
Most users notice improved hydration and softness immediately after the first use. Visible improvements in skin texture and radiance typically appear within 1β2 weeks. In Eight Saints' 28-day clinical study, 5 out of 5 participants agreed their skin felt more hydrated and had a smoother texture, and 4 out of 5 reported brighter-looking skin and reduced fine lines. For maximum wrinkle-reduction benefits from the peptide complex, consistent use for 8β12 weeks is recommended.
Up The Anti is a night cream and should be the last or second-to-last step in your PM routine. Apply after cleansing, toning, serums, and eye cream. If you use a face oil (like Eight Saints High Society), apply that on top as the final step. Do not use under sunscreen or makeup β this is strictly a nighttime product.
Up The Anti has a comedogenic rating of approximately 2 out of 5. It contains isopropyl palmitate (comedogenic rating 4) and some plant oils, but these are balanced by non-comedogenic ingredients like glycerin, aloe, niacinamide, and hyaluronic acid. Most users report no breakouts, but if you are highly acne-prone, patch test first. The niacinamide in the formula may actually help reduce acne for some users.
Up The Anti has an estimated PAO (Period After Opening) of 12 months. Since it comes in a jar, use a clean spatula to scoop out product to minimize bacterial contamination. Keep the lid tightly closed and store away from direct sunlight and heat. Many users report the 2 oz jar lasting 3β4 months with nightly use on face and neck.
Verdict: Eight Saints Up The Anti is a well-formulated, clean anti-aging night cream that delivers on its hydration and firmness promises. The triple peptide complex combined with niacinamide and botanical hyaluronic acid offers a gentle yet effective approach to wrinkle reduction β ideal for those who want anti-aging results without retinol irritation. Backed by a 28-day clinical study and thousands of positive reviews, it excels for dry, normal, and mature skin types. Points deducted for jar packaging (not ideal for active ingredients), lack of fungal acne safety, undisclosed peptide concentrations, and a higher price point compared to drugstore alternatives. If you value clean, cruelty-free, USA-made skincare and want a nourishing peptide night cream, Up The Anti is an excellent choice.
Product Overview
Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.
Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.
Quick Product Notes
Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging Β«promisesΒ» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.
We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.
Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.
Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you
Notable Effects & Ingredients
Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.
We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.
A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.
One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!
Ingredients Related to Skin Types
Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.
EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.
Ingredient Safety Breakdown
Product ingredient list
| EWG | CIR | Ingredient Name & Cosmetic Functions | Notes |
|---|---|---|---|
| 1 |
Water
Solvent, Skin Conditioning
|
|
|
| 0 |
Aloe Ferox Leaf Juice
|
|
|
| 0 |
Carthamus Tinctorius Seed Oil
Masking, Skin Conditioning
|
Hydrating
|
|
| 2 |
Glycerin
Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant, Skin Conditioning
|
Promotes Wound Healing
Hydrating
|
|
| 1 |
Glyceryl Stearate
Emollient, Emulsifying
|
|

