Skip to content

25% Vitamin C + Glutathione Clinical Serum

25% Vitamin C + Glutathione Clinical Serum

Product Description

Product overview

Made in USA PROFESSIONAL

A highly stable, clinical-strength 25% vitamin C serum combining two forms of vitamin C (Tetrahexyldecyl Ascorbate + Ascorbyl Glucoside) with glutathione to visibly improve uneven tone, radiance, elasticity, and firmness without irritating skin.

25% Vitamin C Fragrance-Free Cruelty-Free Vegan Gluten-Free Oil-Soluble + Water-Soluble C Non-Irritating Formula
Pregnancy
Yes
Fungal Acne
No
Comedogenic
1/5
Size
30ml / 1 fl oz
Form
Serum
Concerns
Brightening, Firmness
Key Active
Vitamin C 25%
Price
$62 USD
Real reviews · YouTube Shorts
Why it's different

Clinical-Strength 25% Vitamin C

Two stable forms (23% THD Ascorbate + 2% Ascorbyl Glucoside) for maximum brightening without the irritation of pure L-ascorbic acid.

01

Texture & feel

SENSORY
Consistency
Creamy-silky
Scent
Fragrance-free
Absorption
30-60 seconds
Finish
Dewy glow

Clinical-Strength 25% Vitamin C

Two stable forms (23% THD Ascorbate + 2% Ascorbyl Glucoside) for maximum brightening without the irritation of pure L-ascorbic acid.

Glutathione + GAP Technology

Patented Glutathione Amino Acid Precursors help maintain skin's natural antioxidant levels and minimize oxidative stress.

Enhanced Stability

Oil-soluble vitamin C penetrates deeper into skin layers and remains stable longer than water-soluble forms.

Multi-Antioxidant Complex

Ergothioneine, Vitamin E, Apple Extract, and Rice Bran Extract provide comprehensive free radical protection.

02

Safety & compatibility

SAFE
Pregnancy & Breastfeeding Safe

Vitamin C (including Tetrahexyldecyl Ascorbate) is considered safe during pregnancy and breastfeeding. No retinoids, salicylic acid, or hydroquinone.

Not Fungal Acne (Malassezia) Safe

Contains Polysorbate 60, Sorbitan Isostearate, and Coco-Caprylate/Caprate which may feed Malassezia yeast.

Low Comedogenic Risk

Rated 1/5 comedogenic. Labeled non-comedogenic by the brand. Suitable for most acne-prone skin types.

Compatible with Retinol & AHAs/BHAs

Stable vitamin C derivatives work well with retinol, niacinamide, and exfoliating acids without pH conflicts.

03

Ingredient breakdown

INGREDIENTS

Tetrahexyldecyl Ascorbate 23%Proven

An oil-soluble, highly stable form of Vitamin C that penetrates deeper into skin than water-soluble L-ascorbic acid. Brightens, supports collagen, and provides antioxidant protection without the irritation or pH sensitivity of pure ascorbic acid.

  • Penetration: Oil-soluble nature allows deeper penetration into lipid layers of skin
  • Stability: Much more stable than L-ascorbic acid, less prone to oxidation
  • Gentle: Does not require low pH, making it less irritating
Higher concentrations (5%+) needed for visible brightening effects compared to pure vitamin C, which this formula provides at 23%.

Ascorbyl Glucoside 2%Proven

A water-soluble vitamin C derivative that converts to ascorbic acid in the skin. Works synergistically with the oil-soluble form to provide comprehensive vitamin C benefits across different skin layers.

  • Conversion: Enzymes in skin convert it to pure vitamin C
  • Stability: Very stable in formulations
  • Benefits: Brightening, collagen support, antioxidant protection

Glutathione ActiveProven

A powerful tripeptide antioxidant naturally found in the body. Helps protect skin from oxidative damage, supports vitamin C stability, and may help reduce melanin production for brighter skin.

  • Antioxidant: One of the body's most potent natural antioxidants
  • Synergy: Enhances vitamin C effectiveness and stability
  • Brightening: May help reduce hyperpigmentation

Ergothioneine ActivePromising

A rare amino acid antioxidant found in mushrooms. Supports skin's natural antioxidant defenses and helps protect against environmental stressors and UV-induced damage.

  • Unique: Accumulates in cells exposed to oxidative stress
  • Protection: Shields against UV and pollution damage
  • Support: Boosts skin's innate antioxidant systems

Supporting Antioxidants VariousSupporting

Apple Fruit Extract, Rice Bran Extract, Rosemary Leaf Extract, Sunflower Seed Extract, and Vitamin E (Tocopherol) provide additional antioxidant protection and skin-soothing benefits.

  • Vitamin E: Works synergistically with Vitamin C
  • Plant Extracts: Additional free radical neutralization
  • Hydration: Glycerin, Sodium Hyaluronate, Urea for moisture

41 ingredients

Water/Aqua/Eau, Tetrahexyldecyl Ascorbate, Dimethicone, Glycerin, C9-12 Alkane, Ascorbyl Glucoside, Silica, Pyrus Malus (Apple) Fruit Extract, Hydrogenated Lecithin, Polyglyceryl-6 Polyricinoleate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Xanthan Gum, Glutathione, Ergothioneine, Oryza Sativa (Rice) Bran Extract, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Cetyl Alcohol, Caprylyl Glycol, Lysine Carboxymethyl Cysteinate, Coco-Caprylate/Caprate, Tocopherol, Sodium Citrate, Sodium Phytate, Hexylene Glycol, Ethylhexylglycerin, Helianthus Annuus (Sunflower) Seed Extract, Urea, Mannitol, Caprylic/Capric Triglyceride, Sodium PCA, Rosmarinus Officinalis (Rosemary) Leaf Extract, Polysorbate 60, Sorbitan Isostearate, Trehalose, Ascorbic Acid, Glucose, Vanilla Planifolia Fruit Extract, Polyquaternium-51, Triacetin, Sodium Hyaluronate, Phenoxyethanol

FREE FROM: Parabens, Formaldehydes, Formaldehyde-releasing agents, Phthalates, Mineral Oil, Retinyl Palmitate, Oxybenzone, Coal Tar, Hydroquinone, Sulfates (SLS & SLES), Triclocarban, Triclosan, Added Fragrance
04

Where it fits in your routine

ROUTINE
1
Cleanser
2
Toner
3
Exfoliant
4
This Serum
5
Moisturizer
6
SPF (AM)

Use AM and/or PM. For daytime, always follow with SPF 30+. Can be used with retinol, niacinamide, and exfoliating acids.

05

How to use

HOW TO USE
1

Cleanse & Prep

Start with clean, dry skin. If using toner or exfoliant, apply those first and let absorb.

2

Dispense & Apply

Pump 1-2 pumps into palm. Apply an even layer to face and neck, avoiding direct eye contact.

3

Let Absorb

Allow 30-60 seconds for the serum to absorb before applying next products.

4

Follow Up

Apply moisturizer. In the morning, ALWAYS finish with SPF 30 or higher for best results and protection.

06

Who is it for?

WHO

Perfect for you if:

  • You have stubborn dark spots, sun damage, or hyperpigmentation
  • You want clinical-strength vitamin C without irritation
  • Previous vitamin C serums have irritated your skin
  • You want to improve skin firmness and elasticity
  • You need a stable vitamin C that won't oxidize quickly
  • You want to combine vitamin C with retinol in your routine

Consider alternatives if:

  • You have fungal acne (malassezia folliculitis)
  • You prefer pure L-ascorbic acid serums
  • You want a budget-friendly option under $30
  • You need a completely oil-free formula
  • You're looking for immediate tingling/active sensation
07

Skin type compatibility

SKIN TYPES
Oily Skin
Good

Works well but may feel slightly rich. Best applied at night or with lightweight moisturizer. Non-comedogenic formula won't clog pores.

Dry Skin
Excellent

Creamy texture provides hydration. Glycerin, sodium hyaluronate, and urea help attract and retain moisture.

Combination Skin
Excellent

Balances well across different face zones. Provides hydration where needed without excessive oiliness.

Sensitive Skin
Excellent

Specifically formulated to be non-irritating. Stable vitamin C derivatives don't require low pH, minimizing irritation risk.

Acne-Prone Skin
Good

Non-comedogenic and can help fade post-acne marks. Not suitable for fungal acne due to certain emulsifiers.

08

Results timeline

3+ MONTHS
Week 1-2

Initial Glow

Skin appears more radiant and hydrated. The antioxidant protection starts working immediately against daily environmental damage.

70% noticed immediate radiance
Week 4-6

Tone Improvement

Visible improvement in overall skin tone evenness. Early signs of dark spot fading. Skin texture feels smoother.

65% saw tone improvement
Week 8-12

Significant Brightening

Noticeable reduction in hyperpigmentation and dark spots. Improved firmness and elasticity. Continued brightening effects.

80% reported visible brightening
3+ Months

Optimal Results

Maximum brightening benefits achieved with consistent use. Continued improvement in firmness and prevention of new damage.

85% achieved desired results
09

Ratings by platform

2K+ REVIEWS
Sephora
4.4
Rating
600+
Reviews
Main complaint: Price point feels high for the 1oz size
Amazon
4.3
Rating
500+
Reviews
Main complaint: Some users find the texture slightly greasy
Paula's Choice
4.6
Rating
800+
Reviews
Main complaint: Results take time (8+ weeks for visible changes)
Dermstore
4.5
Rating
200+
Reviews
Main complaint: Some wish for a larger size option
10

Pros & cons

BALANCED

Praised

  • High 25% vitamin C concentration without irritation
  • Highly stable formula that won't oxidize quickly
  • Suitable for sensitive skin types
  • Can be combined with retinol and acids
  • Noticeable brightening and glow
  • Fragrance-free and vegan
  • Airless pump packaging protects formula
  • 60-day money-back guarantee from brand

Criticized

  • High price point ($62 for 1oz)
  • Some find texture slightly greasy/oily
  • Not suitable for fungal acne
  • Results take 8+ weeks to see
  • Small bottle size for the price
  • May not suit those who prefer pure L-ascorbic acid
11

Budget-friendly alternatives (dupes)

DUPES
70% Match
20% Vitamin C + E + Ferulic Acid Serum
$26
Budget Pick

Uses L-ascorbic acid instead of stable derivatives. More potent but less stable and may irritate sensitive skin. Requires refrigeration.

65% Match
Vitamin C Suspension 23% + HA Spheres 2%
$8
Budget Pick

Anhydrous (water-free) suspension formula. Gritty texture, requires mixing with other products. Much more affordable but different application experience.

75% Match
Vitamin C Serum
$30
Budget Pick

Uses Sodium Ascorbyl Phosphate (SAP). Lower concentration but very stable. Includes konjac root, ferulic acid, and hyaluronic acid. Good for sensitive skin.

85% Match
C15 Super Booster
$55
Same Brand

15% pure L-ascorbic acid with vitamin E and ferulic acid. More research-backed form but may cause more irritation. Good stepping stone to this product.

12

Comparison with competitors

SIDE-BY-SIDE

SkinCeuticals C E Ferulic

Vitamin C Type L-Ascorbic Acid
Concentration 15%
Stability Moderate (patented)
Irritation Risk Moderate
Size 30ml
C-Firma Fresh Day Serum
Vitamin C Type L-Ascorbic Acid
Concentration 15%
Stability Good (fresh activation)
Irritation Risk Moderate
Size 30ml
20% Vitamin C + E Ferulic Acid Serum
Vitamin C Type L-Ascorbic Acid
Concentration 20%
Stability Low (oxidizes quickly)
Irritation Risk Higher
Size 30ml
13

Storage & shelf life

12 MONTHS
Period After Opening (PAO)

12 months after opening

Storage

Store in a cool, dry place away from direct sunlight. Refrigeration not required but can extend shelf life.

Packaging

Opaque airless pump bottle protects formula from air and light oxidation

Travel Friendly

Yes, 30ml/1oz is under TSA liquid limits for carry-on luggage

13

Frequently asked questions

FAQ

Yes, this serum is considered safe during pregnancy and breastfeeding. Vitamin C (including the Tetrahexyldecyl Ascorbate and Ascorbyl Glucoside forms used) is generally recognized as safe for topical use during pregnancy. The formula contains no retinoids, salicylic acid, hydroquinone, or other ingredients typically avoided during pregnancy. However, always consult your healthcare provider before introducing new skincare products during pregnancy.

No, this serum is NOT fungal acne safe. It contains several ingredients that can feed Malassezia yeast, including Polysorbate 60, Sorbitan Isostearate, Coco-Caprylate/Caprate, and Polyglyceryl-6 Polyricinoleate. If you have fungal acne, look for vitamin C serums with simpler formulas that avoid these emulsifiers and esters.

Yes! Unlike pure L-ascorbic acid serums that require low pH and can conflict with other actives, this formula uses stable vitamin C derivatives that work well with other active ingredients. You can safely combine it with retinol, niacinamide, AHAs, and BHAs. Paula's Choice recommends starting slowly if using multiple actives and building up tolerance. Many users apply this serum in the AM and retinol at night.

This serum is formulated for all skin types, including sensitive skin. It's particularly well-suited for those with dry to combination skin who appreciate the creamy texture, and those with sensitive skin who have experienced irritation from traditional L-ascorbic acid serums. Those with very oily skin may find it slightly rich. It's ideal for anyone dealing with hyperpigmentation, uneven tone, dullness, or loss of firmness.

Most users notice an immediate radiance boost within the first week. Visible improvement in skin tone evenness typically appears around weeks 4-6. Significant brightening of dark spots and hyperpigmentation usually becomes noticeable at 8-12 weeks of consistent use. For maximum results, use consistently for 3+ months. Remember, topical vitamin C works gradually and prevention of future damage is equally important.

Apply this serum after cleansing, toning, and any watery serums or exfoliants, but before moisturizer and sunscreen. For AM use: Cleanser → Toner → Exfoliant (optional) → This Serum → Moisturizer → Sunscreen SPF 30+. For PM use: Same order, but you can follow with retinol if desired, then moisturizer. The stable formula doesn't require special layering considerations.

This serum has a low comedogenic rating of 1/5 and is labeled non-comedogenic by Paula's Choice. Most users, including those with acne-prone skin, do not experience clogged pores or breakouts. However, individual reactions vary, and if you're very acne-prone, patch testing is recommended. Note that while it's low comedogenic, it's not fungal acne safe.

The serum has a PAO (Period After Opening) of 12 months. Thanks to the stable vitamin C derivatives used and the protective airless pump packaging, this serum maintains its effectiveness much longer than traditional L-ascorbic acid serums. Store in a cool, dry place away from direct sunlight. If the product changes color significantly (turning dark brown/orange), it may have oxidized and should be replaced.

— Skincarisma verdict
4.4 / 5 ★★★★☆

Verdict: Paula's Choice 25% Vitamin C + Glutathione Clinical Serum is an excellent choice for those seeking a high-concentration vitamin C serum without the irritation of pure L-ascorbic acid. The stable formula with dual vitamin C forms, glutathione, and supporting antioxidants delivers visible brightening results over time. While the price point is higher than budget options, the stability, gentle nature, and ability to combine with other actives make it a worthwhile investment for those with sensitive skin or stubborn hyperpigmentation. Not recommended for fungal acne sufferers due to certain emulsifiers.

Product Overview

question
lightbulb What are Quick Product Notes?

Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.

muscle Pro Tip Alert!

Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.

Awesome, I Understand!

Quick Product Notes

Click on icons for more information
question
lightbulb What are Notable Effects & Ingredients?

Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging «promises» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.

We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.

muscle Pro Tip Alert!

Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.

Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you

Awesome, I Understand!

Notable Effects & Ingredients

anti-aging Anti-Aging from 3 ingredient(s):
Tetrahexyldecyl Ascorbate Tocopherol Ascorbic Acid
brightening Brightening from 5 ingredient(s):
Tetrahexyldecyl Ascorbate Glycerin Ascorbyl Glucoside Glutathione Ascorbic Acid
wound Promotes Wound Healing from 4 ingredient(s):
Glycerin Tocopherol Ascorbic Acid Sodium Hyaluronate
question
lightbulb What are Ingredients Related to Skin Type?

Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.

We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.

muscle Pro Tip Alert!

A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.

One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!

Awesome, I Understand!

Ingredients Related to Skin Types

Click on icons for more information
dry-skin Dry Skin
5
oily-skin Oily/Acne-Prone Skin
sensitive-skin Sensitive Skin
question
lightbulb What is the Ingredient Safety Breakdown?

Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.

muscle Pro Tip Alert!

EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.

Awesome, I Understand!

Ingredient Safety Breakdown

EWG Health Ratings
Low risk
Medium risk
High risk
Unknown risk
63% 7% 29%

Product ingredient list

Showing first 5 of 41 ingredients
EWG CIR Ingredient Name & Cosmetic Functions Notes
1 Unknown
Water
Solvent, Skin Conditioning
1 Unknown
Tetrahexyldecyl Ascorbate
Skin Conditioning, Antioxidant
brightening Brightening
anti-aging Anti-Aging
Redness
Texture
Pores
3 A
Dimethicone
Skin Conditioning, Emollient, Antifoaming Agent, Skin Protecting
2 A
Glycerin
Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant, Skin Conditioning
brightening Brightening
Promotes Wound Healing
Hydrating
0 Unknown
C9-12 Alkane
Solvent
VIEW ALL INGREDIENTS