25% Vitamin C + Glutathione Clinical Serum
25% Vitamin C + Glutathione Clinical Serum
Product Description
Product overview
A highly stable, clinical-strength 25% vitamin C serum combining two forms of vitamin C (Tetrahexyldecyl Ascorbate + Ascorbyl Glucoside) with glutathione to visibly improve uneven tone, radiance, elasticity, and firmness without irritating skin.
Clinical-Strength 25% Vitamin C
Two stable forms (23% THD Ascorbate + 2% Ascorbyl Glucoside) for maximum brightening without the irritation of pure L-ascorbic acid.
Texture & feel
SENSORYClinical-Strength 25% Vitamin C
Two stable forms (23% THD Ascorbate + 2% Ascorbyl Glucoside) for maximum brightening without the irritation of pure L-ascorbic acid.
Glutathione + GAP Technology
Patented Glutathione Amino Acid Precursors help maintain skin's natural antioxidant levels and minimize oxidative stress.
Enhanced Stability
Oil-soluble vitamin C penetrates deeper into skin layers and remains stable longer than water-soluble forms.
Multi-Antioxidant Complex
Ergothioneine, Vitamin E, Apple Extract, and Rice Bran Extract provide comprehensive free radical protection.
Safety & compatibility
SAFEVitamin C (including Tetrahexyldecyl Ascorbate) is considered safe during pregnancy and breastfeeding. No retinoids, salicylic acid, or hydroquinone.
Contains Polysorbate 60, Sorbitan Isostearate, and Coco-Caprylate/Caprate which may feed Malassezia yeast.
Rated 1/5 comedogenic. Labeled non-comedogenic by the brand. Suitable for most acne-prone skin types.
Stable vitamin C derivatives work well with retinol, niacinamide, and exfoliating acids without pH conflicts.
Ingredient breakdown
INGREDIENTSTetrahexyldecyl Ascorbate 23%Proven
An oil-soluble, highly stable form of Vitamin C that penetrates deeper into skin than water-soluble L-ascorbic acid. Brightens, supports collagen, and provides antioxidant protection without the irritation or pH sensitivity of pure ascorbic acid.
- Penetration: Oil-soluble nature allows deeper penetration into lipid layers of skin
- Stability: Much more stable than L-ascorbic acid, less prone to oxidation
- Gentle: Does not require low pH, making it less irritating
Ascorbyl Glucoside 2%Proven
A water-soluble vitamin C derivative that converts to ascorbic acid in the skin. Works synergistically with the oil-soluble form to provide comprehensive vitamin C benefits across different skin layers.
- Conversion: Enzymes in skin convert it to pure vitamin C
- Stability: Very stable in formulations
- Benefits: Brightening, collagen support, antioxidant protection
Glutathione ActiveProven
A powerful tripeptide antioxidant naturally found in the body. Helps protect skin from oxidative damage, supports vitamin C stability, and may help reduce melanin production for brighter skin.
- Antioxidant: One of the body's most potent natural antioxidants
- Synergy: Enhances vitamin C effectiveness and stability
- Brightening: May help reduce hyperpigmentation
Ergothioneine ActivePromising
A rare amino acid antioxidant found in mushrooms. Supports skin's natural antioxidant defenses and helps protect against environmental stressors and UV-induced damage.
- Unique: Accumulates in cells exposed to oxidative stress
- Protection: Shields against UV and pollution damage
- Support: Boosts skin's innate antioxidant systems
Supporting Antioxidants VariousSupporting
Apple Fruit Extract, Rice Bran Extract, Rosemary Leaf Extract, Sunflower Seed Extract, and Vitamin E (Tocopherol) provide additional antioxidant protection and skin-soothing benefits.
- Vitamin E: Works synergistically with Vitamin C
- Plant Extracts: Additional free radical neutralization
- Hydration: Glycerin, Sodium Hyaluronate, Urea for moisture
41 ingredients
Water/Aqua/Eau, Tetrahexyldecyl Ascorbate, Dimethicone, Glycerin, C9-12 Alkane, Ascorbyl Glucoside, Silica, Pyrus Malus (Apple) Fruit Extract, Hydrogenated Lecithin, Polyglyceryl-6 Polyricinoleate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Xanthan Gum, Glutathione, Ergothioneine, Oryza Sativa (Rice) Bran Extract, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Cetyl Alcohol, Caprylyl Glycol, Lysine Carboxymethyl Cysteinate, Coco-Caprylate/Caprate, Tocopherol, Sodium Citrate, Sodium Phytate, Hexylene Glycol, Ethylhexylglycerin, Helianthus Annuus (Sunflower) Seed Extract, Urea, Mannitol, Caprylic/Capric Triglyceride, Sodium PCA, Rosmarinus Officinalis (Rosemary) Leaf Extract, Polysorbate 60, Sorbitan Isostearate, Trehalose, Ascorbic Acid, Glucose, Vanilla Planifolia Fruit Extract, Polyquaternium-51, Triacetin, Sodium Hyaluronate, Phenoxyethanol
Where it fits in your routine
ROUTINEUse AM and/or PM. For daytime, always follow with SPF 30+. Can be used with retinol, niacinamide, and exfoliating acids.
How to use
HOW TO USECleanse & Prep
Start with clean, dry skin. If using toner or exfoliant, apply those first and let absorb.
Dispense & Apply
Pump 1-2 pumps into palm. Apply an even layer to face and neck, avoiding direct eye contact.
Let Absorb
Allow 30-60 seconds for the serum to absorb before applying next products.
Follow Up
Apply moisturizer. In the morning, ALWAYS finish with SPF 30 or higher for best results and protection.
Who is it for?
WHOPerfect for you if:
- You have stubborn dark spots, sun damage, or hyperpigmentation
- You want clinical-strength vitamin C without irritation
- Previous vitamin C serums have irritated your skin
- You want to improve skin firmness and elasticity
- You need a stable vitamin C that won't oxidize quickly
- You want to combine vitamin C with retinol in your routine
Consider alternatives if:
- You have fungal acne (malassezia folliculitis)
- You prefer pure L-ascorbic acid serums
- You want a budget-friendly option under $30
- You need a completely oil-free formula
- You're looking for immediate tingling/active sensation
Skin type compatibility
SKIN TYPESWorks well but may feel slightly rich. Best applied at night or with lightweight moisturizer. Non-comedogenic formula won't clog pores.
Creamy texture provides hydration. Glycerin, sodium hyaluronate, and urea help attract and retain moisture.
Balances well across different face zones. Provides hydration where needed without excessive oiliness.
Specifically formulated to be non-irritating. Stable vitamin C derivatives don't require low pH, minimizing irritation risk.
Non-comedogenic and can help fade post-acne marks. Not suitable for fungal acne due to certain emulsifiers.
Results timeline
3+ MONTHSInitial Glow
Skin appears more radiant and hydrated. The antioxidant protection starts working immediately against daily environmental damage.
70% noticed immediate radianceTone Improvement
Visible improvement in overall skin tone evenness. Early signs of dark spot fading. Skin texture feels smoother.
65% saw tone improvementSignificant Brightening
Noticeable reduction in hyperpigmentation and dark spots. Improved firmness and elasticity. Continued brightening effects.
80% reported visible brighteningOptimal Results
Maximum brightening benefits achieved with consistent use. Continued improvement in firmness and prevention of new damage.
85% achieved desired resultsRatings by platform
2K+ REVIEWSPros & cons
BALANCEDPraised
- High 25% vitamin C concentration without irritation
- Highly stable formula that won't oxidize quickly
- Suitable for sensitive skin types
- Can be combined with retinol and acids
- Noticeable brightening and glow
- Fragrance-free and vegan
- Airless pump packaging protects formula
- 60-day money-back guarantee from brand
Criticized
- High price point ($62 for 1oz)
- Some find texture slightly greasy/oily
- Not suitable for fungal acne
- Results take 8+ weeks to see
- Small bottle size for the price
- May not suit those who prefer pure L-ascorbic acid
Budget-friendly alternatives (dupes)
DUPESUses L-ascorbic acid instead of stable derivatives. More potent but less stable and may irritate sensitive skin. Requires refrigeration.
Anhydrous (water-free) suspension formula. Gritty texture, requires mixing with other products. Much more affordable but different application experience.
Uses Sodium Ascorbyl Phosphate (SAP). Lower concentration but very stable. Includes konjac root, ferulic acid, and hyaluronic acid. Good for sensitive skin.
15% pure L-ascorbic acid with vitamin E and ferulic acid. More research-backed form but may cause more irritation. Good stepping stone to this product.
Comparison with competitors
SIDE-BY-SIDEPaula's Choice 25% Vitamin C
SkinCeuticals C E Ferulic
Storage & shelf life
12 MONTHS12 months after opening
Store in a cool, dry place away from direct sunlight. Refrigeration not required but can extend shelf life.
Opaque airless pump bottle protects formula from air and light oxidation
Yes, 30ml/1oz is under TSA liquid limits for carry-on luggage
Frequently asked questions
FAQYes, this serum is considered safe during pregnancy and breastfeeding. Vitamin C (including the Tetrahexyldecyl Ascorbate and Ascorbyl Glucoside forms used) is generally recognized as safe for topical use during pregnancy. The formula contains no retinoids, salicylic acid, hydroquinone, or other ingredients typically avoided during pregnancy. However, always consult your healthcare provider before introducing new skincare products during pregnancy.
No, this serum is NOT fungal acne safe. It contains several ingredients that can feed Malassezia yeast, including Polysorbate 60, Sorbitan Isostearate, Coco-Caprylate/Caprate, and Polyglyceryl-6 Polyricinoleate. If you have fungal acne, look for vitamin C serums with simpler formulas that avoid these emulsifiers and esters.
Yes! Unlike pure L-ascorbic acid serums that require low pH and can conflict with other actives, this formula uses stable vitamin C derivatives that work well with other active ingredients. You can safely combine it with retinol, niacinamide, AHAs, and BHAs. Paula's Choice recommends starting slowly if using multiple actives and building up tolerance. Many users apply this serum in the AM and retinol at night.
This serum is formulated for all skin types, including sensitive skin. It's particularly well-suited for those with dry to combination skin who appreciate the creamy texture, and those with sensitive skin who have experienced irritation from traditional L-ascorbic acid serums. Those with very oily skin may find it slightly rich. It's ideal for anyone dealing with hyperpigmentation, uneven tone, dullness, or loss of firmness.
Most users notice an immediate radiance boost within the first week. Visible improvement in skin tone evenness typically appears around weeks 4-6. Significant brightening of dark spots and hyperpigmentation usually becomes noticeable at 8-12 weeks of consistent use. For maximum results, use consistently for 3+ months. Remember, topical vitamin C works gradually and prevention of future damage is equally important.
Apply this serum after cleansing, toning, and any watery serums or exfoliants, but before moisturizer and sunscreen. For AM use: Cleanser → Toner → Exfoliant (optional) → This Serum → Moisturizer → Sunscreen SPF 30+. For PM use: Same order, but you can follow with retinol if desired, then moisturizer. The stable formula doesn't require special layering considerations.
This serum has a low comedogenic rating of 1/5 and is labeled non-comedogenic by Paula's Choice. Most users, including those with acne-prone skin, do not experience clogged pores or breakouts. However, individual reactions vary, and if you're very acne-prone, patch testing is recommended. Note that while it's low comedogenic, it's not fungal acne safe.
The serum has a PAO (Period After Opening) of 12 months. Thanks to the stable vitamin C derivatives used and the protective airless pump packaging, this serum maintains its effectiveness much longer than traditional L-ascorbic acid serums. Store in a cool, dry place away from direct sunlight. If the product changes color significantly (turning dark brown/orange), it may have oxidized and should be replaced.
Verdict: Paula's Choice 25% Vitamin C + Glutathione Clinical Serum is an excellent choice for those seeking a high-concentration vitamin C serum without the irritation of pure L-ascorbic acid. The stable formula with dual vitamin C forms, glutathione, and supporting antioxidants delivers visible brightening results over time. While the price point is higher than budget options, the stability, gentle nature, and ability to combine with other actives make it a worthwhile investment for those with sensitive skin or stubborn hyperpigmentation. Not recommended for fungal acne sufferers due to certain emulsifiers.
Product Overview
Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.
Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.
Quick Product Notes
Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging «promises» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.
We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.
Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.
Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you
Notable Effects & Ingredients
Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.
We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.
A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.
One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!
Ingredients Related to Skin Types
Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.
EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.
Ingredient Safety Breakdown
Product ingredient list
| EWG | CIR | Ingredient Name & Cosmetic Functions | Notes |
|---|---|---|---|
| 1 |
Water
Solvent, Skin Conditioning
|
|
|
| 1 |
Tetrahexyldecyl Ascorbate
Skin Conditioning, Antioxidant
|
Redness
Texture
Pores
|
|
| 3 |
Dimethicone
Skin Conditioning, Emollient, Antifoaming Agent, Skin Protecting
|
|
|
| 2 |
Glycerin
Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant, Skin Conditioning
|
Promotes Wound Healing
Hydrating
|
|
| 0 |
C9-12 Alkane
Solvent
|
|







