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Bio Serum Firm

Bio Serum Firm

Product Description

Product overview

Made in Various INTERNATIONAL

A medical-grade anti-aging serum combining the highest concentration of human growth factors (PSP) with proprietary peptides to visibly firm, smooth, and brighten skin. Clinically shown to improve texture, hydration, and fine lines in as little as 6 days. Lightweight, fast-absorbing, and fragrance-free for all skin types.

Dermatologist Tested Non-Comedogenic Fragrance-Free Paraben-Free Oil-Free Gluten-Free Not Tested on Animals Dye-Free
Pregnancy
Caution
Fungal Acne
No
Comedogenic
1/5
Size
30 ml / 1 fl oz
Type
Serum
Concerns
Aging, Firmness
Key Active
Growth Factors + Peptides
Grade
Medical / Rx
Real reviews · YouTube Shorts
Why it's different

Human Growth Factors (PSP)

Exclusive cutaneous lysate supports collagen, elastin, and hyaluronic acid production to rejuvenate aging skin at the cellular level.

01

Texture & feel

SENSORY
Consistency
Lightweight serum
Scent
Fragrance-free
Absorption
30–60 seconds
Finish
Silky, natural

Human Growth Factors (PSP)

Exclusive cutaneous lysate supports collagen, elastin, and hyaluronic acid production to rejuvenate aging skin at the cellular level.

Triple Peptide Complex

Tetrapeptide-21, Palmitoyl Tripeptide-1 Acetate, and Trifluoroacetyl Tripeptide-2 (Progeline) work together to boost firmness, elasticity, and redefine facial contours.

Dual Hyaluronic Acid

Sodium Hyaluronate plus Hydrolyzed Sodium Hyaluronate penetrate multiple skin layers for deep, lasting hydration and plumping.

Brightening Complex

Aminopropyl Ascorbyl Phosphate (Vitamin C derivative) and Acetyl Glucosamine help even tone, reduce hyperpigmentation, and restore radiance.

02

Safety & compatibility

SAFE
Pregnancy & Breastfeeding

No retinoids, salicylic acid, or chemical sunscreens detected. However, growth factors (cutaneous lysate) lack dedicated safety data during pregnancy. Consult your physician before use.

Fungal Acne (Malassezia)

Contains Polysorbate 60 and Sorbitan Isostearate, which are known fungal acne triggers. Not recommended for those prone to fungal acne (pityrosporum folliculitis).

Non-Comedogenic

Dermatologist-tested and labeled non-comedogenic. Free of heavy oils and known pore-clogging ingredients. Comedogenic rating: 1/5.

Sensitive Skin Friendly

Fragrance-free, dye-free, paraben-free, and silicone-free formula. Low irritation potential. Patch test recommended for very reactive skin.

Retinol & Acid Compatible

Can be paired with retinol and vitamin C. When combining with exfoliating acids (AHA/BHA), alternate nights to minimize irritation risk.

Post-Procedure Use

Designed as a post-procedure product to support skin healing and recovery after aesthetic treatments such as lasers, peels, and microneedling.

03

Ingredient breakdown

INGREDIENTS

Cutaneous Lysate (PSP) ProprietaryProven

NEOCUTIS's signature ingredient: a unique blend of human growth factors, cytokines, and interleukins derived from a proprietary fibroblast culture. Stimulates the skin's natural repair mechanisms to promote collagen, elastin, and hyaluronic acid production.

  • Origin: Developed from pediatric wound-healing research at University Hospital of Lausanne, Switzerland
  • Clinical: 6-month study showed 64% improved facial tone/texture, 73% improved hydration, 91% would continue use
  • Mechanism: Provides a balanced cocktail of growth factors that signal fibroblasts to produce new extracellular matrix components

Tetrapeptide-21 ProprietaryPromising

A collagen-boosting peptide that stimulates type I collagen synthesis. Works alongside other peptides in the formula to improve skin firmness, density, and elasticity.

  • Function: Signals fibroblasts to increase collagen production, helping restore structural integrity
  • Synergy: Works in tandem with growth factors for amplified anti-aging effects

Trifluoroacetyl Tripeptide-2 (Progeline) ProprietaryPromising

An anti-sagging peptide that works by inhibiting progerin, a cell-aging accelerator protein. Helps redefine facial contours and counteract skin laxity.

  • In-vivo study: 2% Progeline cream lifted the sagging jawline by up to 10% in 56 days
  • Elasticity: Improved skin firmness and elasticity by approximately 20% in 28 days
  • Mechanism: Inhibits progerin production, bringing cell activity closer to that of younger cells

Sodium Hyaluronate + Hydrolyzed Sodium Hyaluronate Multi-weightProven

Two forms of hyaluronic acid at different molecular weights for multi-layer hydration. The standard form hydrates the surface, while the hydrolyzed form penetrates deeper for plumping from within.

  • Capacity: Hyaluronic acid can hold up to 1,000x its weight in water
  • Clinical benefit: Increases skin elasticity and seals in moisture for long-lasting hydration

Aminopropyl Ascorbyl Phosphate StabilizedPromising

A stable Vitamin C derivative that brightens the complexion, helps even skin tone, and provides antioxidant protection against free radical damage without the instability of pure ascorbic acid.

  • Stability: More stable than L-Ascorbic Acid; less prone to oxidation
  • Function: Supports collagen synthesis and helps neutralize UV-induced free radicals

Acetyl Glucosamine ActiveProven

An amino sugar that exfoliates gently, reduces hyperpigmentation, and supports hyaluronic acid synthesis in the skin. Clinically shown to help with both anti-aging and brightening.

  • Study: Topical application shown to reduce facial hyperpigmentation and improve skin smoothness
  • Mechanism: Inhibits melanin production and supports the skin's natural exfoliation process

35 ingredients

Water (Aqua), Glycerin, Caprylic/Capric Triglyceride, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Squalane, Aminopropyl Ascorbyl Phosphate, Sodium Hyaluronate, Hydrolyzed Sodium Hyaluronate, Cutaneous Lysate, Tetrapeptide-21, Palmitoyl Tripeptide-1 Acetate, Butylene Glycol, Ethylhexylglycerin, Pullulan, Acetyl Glucosamine, Ethylene/Acrylic Acid Copolymer, Polysorbate 60, Proline, Arginine, Glycine, Glutamine, Chlorphenesin, Nannochloropsis Oculata Extract, Capryloyl Carnosine, Poloxamer 338, Silica, Trifluoroacetyl Tripeptide-2, Dextran, Sorbitan Isostearate, Potassium Sorbate, Sodium Benzoate, Tocopherol, Disodium EDTA, Sodium Hydroxide, Phenoxyethanol

FREE FROM: Parabens, Fragrance, Dyes/Color Additives, Silicones, Sulfates, PEGs, Gluten, Mineral Oil, Petroleum, Alcohol (Drying), Retinoids, Hydroquinone, Coconut Derivatives
04

Where it fits in your routine

ROUTINE
1
Cleanser
2
Toner
3
Bio Serum Firm
4
Moisturizer
5
Eye Cream
6
Sunscreen (AM)

Apply morning and/or evening after cleansing. Follow with moisturizer (Journée Firm Riche AM / Bio Cream Firm PM). Always use SPF during the day.

05

How to use

HOW TO USE
1

Cleanse

Start with a gentle cleanser (such as NEOCUTIS Neo Cleanse) to remove makeup, dirt, and impurities. Pat skin dry.

2

Apply 2–3 Pumps

Dispense 2–3 pumps of Bio Serum Firm onto fingertips. Gently smooth over face, neck, and décolleté in upward motions, avoiding the immediate eye area.

3

Allow Absorption

Wait 60 seconds for the serum to fully absorb before applying the next product. The lightweight formula sinks in without residue.

4

Layer Moisturizer + SPF

Follow with your moisturizer. In the morning, finish with a broad-spectrum SPF 30+. For sensitive skin, start with every-other-night use and build up.

06

Who is it for?

WHO

Perfect for you if:

  • You want a medical-grade anti-aging serum with proven growth factor technology
  • You're concerned about loss of firmness, elasticity, and sagging skin
  • You have fine lines, wrinkles, or crepey texture on face, neck, or décolleté
  • You want brighter, more even skin tone alongside firming benefits
  • You prefer a fragrance-free, lightweight serum that layers well
  • You're recovering from aesthetic procedures (laser, peels, microneedling)

Consider alternatives if:

  • You're on a tight budget (this is a premium investment at ~$275/30ml)
  • You have fungal acne (malassezia) — formula contains known triggers
  • You're looking for a standalone moisturizer — this is a treatment serum
  • You want a vegan or plant-based product (contains human-derived growth factors)
  • You prefer products with a long list of natural/botanical ingredients
07

Skin type compatibility

SKIN TYPES
Normal Skin
Excellent

Ideal match. Lightweight formula absorbs perfectly, delivering growth factors and peptides without disrupting natural balance.

Dry Skin
Good

Provides hydration via dual hyaluronic acid and squalane, but very dry skin will need a richer moisturizer on top (such as Bio Cream Firm Riche).

Oily Skin
Good

Oil-free and lightweight with a non-greasy finish. Absorbs quickly without adding shine. Non-comedogenic formula is a plus.

Combination Skin
Excellent

Balances hydration across different zones. Silky texture works well for both oily T-zone and drier cheek areas.

Sensitive Skin
Good

Fragrance-free, dye-free, and dermatologist-tested. Many sensitive-skin users report excellent tolerance, but patch test first and start with every-other-night use.

Mature Skin
Excellent

Primary target audience. Growth factors and peptides specifically address age-related concerns like laxity, wrinkles, and loss of volume.

08

Results timeline

3–6 MONTHS
Day 6

Immediate Hydration & Smoothness

Skin feels smoother, tighter, firmer, and more hydrated. Clinical grader assessment confirms improved texture and brightness in under one week.

Noticeable from day 6
Week 2–4

Visible Firming & Glow

Users report a visible improvement in firmness, particularly around the mouth, chin, and jawline. Skin appears brighter and more plump with enhanced radiance.

88% noticed smoother skin
Week 8

Significant Anti-Aging Results

Clinical study data at 8 weeks shows meaningful reductions in the appearance of fine lines and wrinkles, with continued improvements in texture, brightness, and smoothness.

94% improved texture, 92% brightness, 77% fine lines
3–6 Months

Cumulative Rejuvenation

Long-term users report ongoing improvements in skin density, firmness, and overall youthful appearance. Collagen and elastin remodeling continues with consistent use.

Best results with consistent long-term use
09

Ratings by platform

593+ REVIEWS
Amazon
4.3
Rating
250+
Reviews
Main complaint: Very expensive for a 30ml bottle; some question value for money
Dermstore
4.2
Rating
120+
Reviews
Main complaint: A few users experienced breakouts; product runs out quickly with twice-daily use
LovelySkin
4.7
Rating
200+
Reviews
Main complaint: High price point; small bottle size doesn't last long enough
Walmart
4.3
Rating
23+
Reviews
Main complaint: Concerns about product authenticity from third-party sellers
10

Pros & cons

BALANCED

Praised

  • Clinically proven results visible in as little as 6 days
  • Highest concentration of growth factors + peptides from NEOCUTIS
  • Lightweight, silky texture absorbs quickly without residue
  • Fragrance-free and gentle enough for sensitive skin
  • Multi-tasking: firms, hydrates, brightens, and smooths in one step
  • Excellent for neck and décolleté firming (not just face)
  • Dermatologist-recommended and backed by clinical studies
  • Layers well under makeup and other products

Criticized

  • Premium price (~$275 for 30ml) puts it out of reach for many
  • Small bottle runs out quickly with recommended twice-daily use (4–6 weeks)
  • Some users report breakouts, particularly around the chin area
  • Not vegan — contains human-derived growth factors (cutaneous lysate)
  • Not fungal acne safe due to Polysorbate 60 and Sorbitan Isostearate
  • Results require ongoing, consistent use — stopping reverses benefits
  • Growth factor concentrations are proprietary (not disclosed)
11

Budget-friendly alternatives (dupes)

DUPES
65% Match
Multi-Peptide + HA Serum
$17.90
Budget Pick

Multi-peptide formula with hyaluronic acid targets similar concerns (wrinkles, firmness). Lacks growth factors entirely, so anti-aging potency is significantly lower. Great entry-level peptide serum at a fraction of the price.

60% Match
Regenerist Micro-Sculpting Cream Face Moisturizer
$28.99
Budget Pick

Contains niacinamide, peptides, and hyaluronic acid for firming and hydration. Drugstore price point but a cream formula (not serum), and lacks growth factor technology. Good for those wanting basic peptide benefits affordably.

70% Match
EGF Serum
$165.00
Mid-Range

Features barley-derived Epidermal Growth Factor (EGF) as the hero ingredient. Closer in concept with growth factor technology but plant-derived instead of human. Simpler formula without the peptide complex.

12

Comparison with competitors

SIDE-BY-SIDE
TNS® Advanced+ Serum

SkinMedica TNS Advanced+ Serum

Key Technology TNS (450+ Growth Factors + Peptides)
Size 28.4 g
Results Onset 2 weeks
Fragrance-Free Light scent
Texture Slightly thicker gel-cream
Best For Deep wrinkles, overall rejuvenation
The Rich Cream
Key Technology TFC8 (Trigger Factor Complex)
Size 50 ml
Results Onset 4–6 weeks
Fragrance-Free Yes
Texture Rich cream
Best For Hydration, barrier repair, overall renewal

SkinCeuticals C E Ferulic

Key Technology 15% Vitamin C + Vitamin E + Ferulic Acid
Size 30 ml
Results Onset 4–8 weeks
Fragrance-Free No (has scent)
Texture Liquid serum
Best For Antioxidant protection, brightening
13

Storage & shelf life

12 MONTHS
Period After Opening (PAO)

12 months after opening

Storage

Store at room temperature in a cool, dry place. Avoid direct sunlight and extreme heat. Do not refrigerate unless directed.

Packaging

Airless pump bottle — protects active ingredients from oxidation and ensures hygienic dispensing down to the last drop.

Travel Friendly

Yes, 30ml is under the 100ml TSA carry-on limit. Compact airless pump is leak-resistant.

13

Frequently asked questions

FAQ

Bio Serum Firm does not contain retinoids, salicylic acid, hydroquinone, or chemical sunscreens — the most commonly flagged pregnancy-unsafe ingredients. However, it does contain human growth factors (cutaneous lysate), and there is insufficient clinical data on their safety during pregnancy and breastfeeding. NEOCUTIS does not provide official pregnancy safety guidance. We recommend consulting your OB-GYN or dermatologist before using this product while pregnant or nursing.

No. Bio Serum Firm contains Polysorbate 60 and Sorbitan Isostearate, both of which are known triggers for malassezia (the yeast responsible for fungal acne). If you are prone to fungal acne or pityrosporum folliculitis, this product is not recommended. Consider a fungal-acne-safe alternative without polysorbates or fatty acid esters.

Yes, Bio Serum Firm is generally compatible with retinol, vitamin C, and chemical exfoliants. It already contains a stabilized vitamin C derivative (Aminopropyl Ascorbyl Phosphate). For retinol: apply Bio Serum Firm in the morning and retinol at night, or alternate nights. For AHA/BHA: avoid layering directly on the same application — use acids first and allow them to absorb, or use on alternate nights to minimize irritation risk.

Bio Serum Firm is formulated for all skin types: normal, dry, oily, combination, sensitive, and mature. It is particularly well-suited for mature and aging skin concerned with loss of firmness, fine lines, wrinkles, and uneven texture. The lightweight, oil-free formula absorbs well on oily skin, while the dual hyaluronic acid and squalane provide sufficient hydration for dry skin (though very dry skin may need additional moisturizer).

Clinical studies show initial improvements in hydration, smoothness, and brightness can be noticed in as little as 6 days. More significant firming and wrinkle reduction typically become visible at 4–8 weeks of consistent twice-daily use. At 8 weeks, clinical data showed 94% improvement in texture, 92% in brightness, 88% in smoothness, and 77% in fine lines. Results continue to improve with long-term use over 3–6 months.

Apply Bio Serum Firm after cleansing (and toning, if applicable) but before moisturizer. In a morning routine: Cleanser → Toner → Bio Serum Firm → Moisturizer → Sunscreen. In an evening routine: Cleanser → Toner → Bio Serum Firm → Night Cream. If using other serums, apply Bio Serum Firm first as it is a treatment-level product, then layer lighter hydrating serums on top.

Bio Serum Firm is labeled non-comedogenic and dermatologist-tested. It scores a 1 out of 5 on the comedogenic scale, meaning it has a very low likelihood of clogging pores. The formula is oil-free, silicone-free, and free of heavy occlusives. However, a small number of users have reported breakouts (particularly hormonal acne around the chin), so individual results may vary. If you are acne-prone, patch test first.

The estimated Period After Opening (PAO) is 12 months. However, due to the presence of active growth factors and peptides, using the product within 6–8 months of opening is ideal for maximum potency. The airless pump packaging helps protect the formula from oxidation and contamination. With twice-daily use (2–3 pumps per application), the 30ml bottle typically lasts 4–6 weeks.

— Skincarisma verdict
4.5 / 5 ★★★★★

Verdict: NEOCUTIS Bio Serum Firm is one of the most scientifically advanced anti-aging serums available, combining the highest concentration of human growth factors with a triple peptide complex in a lightweight, elegant formula. Clinical data showing visible results in 6 days is compelling, and the 8-week study results across texture (94%), brightness (92%), and fine lines (77%) are impressive. The fragrance-free, non-comedogenic formula suits most skin types beautifully. The main drawback is the premium price point (~$275 for 30ml), which means the bottle runs out quickly with regular use. It's also not suitable for those with fungal acne. For those willing to invest in medical-grade anti-aging, this serum delivers on its promises and has earned a devoted following among dermatologists and mature-skin users alike.

Product Overview

question
lightbulb What are Quick Product Notes?

Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.

muscle Pro Tip Alert!

Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.

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Quick Product Notes

Click on icons for more information
question
lightbulb What are Notable Effects & Ingredients?

Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging «promises» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.

We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.

muscle Pro Tip Alert!

Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.

Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you

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Notable Effects & Ingredients

anti-aging Anti-Aging from 1 ingredient(s):
Tocopherol
brightening Brightening from 3 ingredient(s):
Glycerin Aminopropyl Ascorbyl Phosphate Acetyl Glucosamine
wound Promotes Wound Healing from 5 ingredient(s):
Glycerin Sodium Hyaluronate Hydrolyzed Sodium Hyaluronate Arginine Tocopherol
question
lightbulb What are Ingredients Related to Skin Type?

Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.

We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.

muscle Pro Tip Alert!

A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.

One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!

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Ingredients Related to Skin Types

Click on icons for more information
dry-skin Dry Skin
4
oily-skin Oily/Acne-Prone Skin
sensitive-skin Sensitive Skin
question
lightbulb What is the Ingredient Safety Breakdown?

Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.

muscle Pro Tip Alert!

EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.

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Ingredient Safety Breakdown

EWG Health Ratings
Low risk
Medium risk
High risk
Unknown risk
44% 14% 41%

Product ingredient list

Showing first 5 of 34 ingredients
EWG CIR Ingredient Name & Cosmetic Functions Notes
1 Unknown
Water
Solvent, Skin Conditioning
2 A
Glycerin
Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant, Skin Conditioning
brightening Brightening
Promotes Wound Healing
Hydrating
1 A
Caprylic/Capric Triglyceride
Solvent, Skin Conditioning, Masking, Perfuming, Emollient
0 Unknown
Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Emulsion Stabilising
1 A
Squalane
Skin Conditioning, Emollient, Hair Conditioning, Refatting
Hydrating
VIEW ALL INGREDIENTS