Bio Serum Firm
Bio Serum Firm
Product Description
Product overview
A medical-grade anti-aging serum combining the highest concentration of human growth factors (PSP) with proprietary peptides to visibly firm, smooth, and brighten skin. Clinically shown to improve texture, hydration, and fine lines in as little as 6 days. Lightweight, fast-absorbing, and fragrance-free for all skin types.
Human Growth Factors (PSP)
Exclusive cutaneous lysate supports collagen, elastin, and hyaluronic acid production to rejuvenate aging skin at the cellular level.
Texture & feel
SENSORYHuman Growth Factors (PSP)
Exclusive cutaneous lysate supports collagen, elastin, and hyaluronic acid production to rejuvenate aging skin at the cellular level.
Triple Peptide Complex
Tetrapeptide-21, Palmitoyl Tripeptide-1 Acetate, and Trifluoroacetyl Tripeptide-2 (Progeline) work together to boost firmness, elasticity, and redefine facial contours.
Dual Hyaluronic Acid
Sodium Hyaluronate plus Hydrolyzed Sodium Hyaluronate penetrate multiple skin layers for deep, lasting hydration and plumping.
Brightening Complex
Aminopropyl Ascorbyl Phosphate (Vitamin C derivative) and Acetyl Glucosamine help even tone, reduce hyperpigmentation, and restore radiance.
Safety & compatibility
SAFENo retinoids, salicylic acid, or chemical sunscreens detected. However, growth factors (cutaneous lysate) lack dedicated safety data during pregnancy. Consult your physician before use.
Contains Polysorbate 60 and Sorbitan Isostearate, which are known fungal acne triggers. Not recommended for those prone to fungal acne (pityrosporum folliculitis).
Dermatologist-tested and labeled non-comedogenic. Free of heavy oils and known pore-clogging ingredients. Comedogenic rating: 1/5.
Fragrance-free, dye-free, paraben-free, and silicone-free formula. Low irritation potential. Patch test recommended for very reactive skin.
Can be paired with retinol and vitamin C. When combining with exfoliating acids (AHA/BHA), alternate nights to minimize irritation risk.
Designed as a post-procedure product to support skin healing and recovery after aesthetic treatments such as lasers, peels, and microneedling.
Ingredient breakdown
INGREDIENTSCutaneous Lysate (PSP) ProprietaryProven
NEOCUTIS's signature ingredient: a unique blend of human growth factors, cytokines, and interleukins derived from a proprietary fibroblast culture. Stimulates the skin's natural repair mechanisms to promote collagen, elastin, and hyaluronic acid production.
- Origin: Developed from pediatric wound-healing research at University Hospital of Lausanne, Switzerland
- Clinical: 6-month study showed 64% improved facial tone/texture, 73% improved hydration, 91% would continue use
- Mechanism: Provides a balanced cocktail of growth factors that signal fibroblasts to produce new extracellular matrix components
Tetrapeptide-21 ProprietaryPromising
A collagen-boosting peptide that stimulates type I collagen synthesis. Works alongside other peptides in the formula to improve skin firmness, density, and elasticity.
- Function: Signals fibroblasts to increase collagen production, helping restore structural integrity
- Synergy: Works in tandem with growth factors for amplified anti-aging effects
Trifluoroacetyl Tripeptide-2 (Progeline) ProprietaryPromising
An anti-sagging peptide that works by inhibiting progerin, a cell-aging accelerator protein. Helps redefine facial contours and counteract skin laxity.
- In-vivo study: 2% Progeline cream lifted the sagging jawline by up to 10% in 56 days
- Elasticity: Improved skin firmness and elasticity by approximately 20% in 28 days
- Mechanism: Inhibits progerin production, bringing cell activity closer to that of younger cells
Sodium Hyaluronate + Hydrolyzed Sodium Hyaluronate Multi-weightProven
Two forms of hyaluronic acid at different molecular weights for multi-layer hydration. The standard form hydrates the surface, while the hydrolyzed form penetrates deeper for plumping from within.
- Capacity: Hyaluronic acid can hold up to 1,000x its weight in water
- Clinical benefit: Increases skin elasticity and seals in moisture for long-lasting hydration
Aminopropyl Ascorbyl Phosphate StabilizedPromising
A stable Vitamin C derivative that brightens the complexion, helps even skin tone, and provides antioxidant protection against free radical damage without the instability of pure ascorbic acid.
- Stability: More stable than L-Ascorbic Acid; less prone to oxidation
- Function: Supports collagen synthesis and helps neutralize UV-induced free radicals
Acetyl Glucosamine ActiveProven
An amino sugar that exfoliates gently, reduces hyperpigmentation, and supports hyaluronic acid synthesis in the skin. Clinically shown to help with both anti-aging and brightening.
- Study: Topical application shown to reduce facial hyperpigmentation and improve skin smoothness
- Mechanism: Inhibits melanin production and supports the skin's natural exfoliation process
35 ingredients
Water (Aqua), Glycerin, Caprylic/Capric Triglyceride, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Squalane, Aminopropyl Ascorbyl Phosphate, Sodium Hyaluronate, Hydrolyzed Sodium Hyaluronate, Cutaneous Lysate, Tetrapeptide-21, Palmitoyl Tripeptide-1 Acetate, Butylene Glycol, Ethylhexylglycerin, Pullulan, Acetyl Glucosamine, Ethylene/Acrylic Acid Copolymer, Polysorbate 60, Proline, Arginine, Glycine, Glutamine, Chlorphenesin, Nannochloropsis Oculata Extract, Capryloyl Carnosine, Poloxamer 338, Silica, Trifluoroacetyl Tripeptide-2, Dextran, Sorbitan Isostearate, Potassium Sorbate, Sodium Benzoate, Tocopherol, Disodium EDTA, Sodium Hydroxide, Phenoxyethanol
Where it fits in your routine
ROUTINEApply morning and/or evening after cleansing. Follow with moisturizer (Journée Firm Riche AM / Bio Cream Firm PM). Always use SPF during the day.
How to use
HOW TO USECleanse
Start with a gentle cleanser (such as NEOCUTIS Neo Cleanse) to remove makeup, dirt, and impurities. Pat skin dry.
Apply 2–3 Pumps
Dispense 2–3 pumps of Bio Serum Firm onto fingertips. Gently smooth over face, neck, and décolleté in upward motions, avoiding the immediate eye area.
Allow Absorption
Wait 60 seconds for the serum to fully absorb before applying the next product. The lightweight formula sinks in without residue.
Layer Moisturizer + SPF
Follow with your moisturizer. In the morning, finish with a broad-spectrum SPF 30+. For sensitive skin, start with every-other-night use and build up.
Who is it for?
WHOPerfect for you if:
- You want a medical-grade anti-aging serum with proven growth factor technology
- You're concerned about loss of firmness, elasticity, and sagging skin
- You have fine lines, wrinkles, or crepey texture on face, neck, or décolleté
- You want brighter, more even skin tone alongside firming benefits
- You prefer a fragrance-free, lightweight serum that layers well
- You're recovering from aesthetic procedures (laser, peels, microneedling)
Consider alternatives if:
- You're on a tight budget (this is a premium investment at ~$275/30ml)
- You have fungal acne (malassezia) — formula contains known triggers
- You're looking for a standalone moisturizer — this is a treatment serum
- You want a vegan or plant-based product (contains human-derived growth factors)
- You prefer products with a long list of natural/botanical ingredients
Skin type compatibility
SKIN TYPESIdeal match. Lightweight formula absorbs perfectly, delivering growth factors and peptides without disrupting natural balance.
Provides hydration via dual hyaluronic acid and squalane, but very dry skin will need a richer moisturizer on top (such as Bio Cream Firm Riche).
Oil-free and lightweight with a non-greasy finish. Absorbs quickly without adding shine. Non-comedogenic formula is a plus.
Balances hydration across different zones. Silky texture works well for both oily T-zone and drier cheek areas.
Fragrance-free, dye-free, and dermatologist-tested. Many sensitive-skin users report excellent tolerance, but patch test first and start with every-other-night use.
Primary target audience. Growth factors and peptides specifically address age-related concerns like laxity, wrinkles, and loss of volume.
Results timeline
3–6 MONTHSImmediate Hydration & Smoothness
Skin feels smoother, tighter, firmer, and more hydrated. Clinical grader assessment confirms improved texture and brightness in under one week.
Noticeable from day 6Visible Firming & Glow
Users report a visible improvement in firmness, particularly around the mouth, chin, and jawline. Skin appears brighter and more plump with enhanced radiance.
88% noticed smoother skinSignificant Anti-Aging Results
Clinical study data at 8 weeks shows meaningful reductions in the appearance of fine lines and wrinkles, with continued improvements in texture, brightness, and smoothness.
94% improved texture, 92% brightness, 77% fine linesCumulative Rejuvenation
Long-term users report ongoing improvements in skin density, firmness, and overall youthful appearance. Collagen and elastin remodeling continues with consistent use.
Best results with consistent long-term useRatings by platform
593+ REVIEWSPros & cons
BALANCEDPraised
- Clinically proven results visible in as little as 6 days
- Highest concentration of growth factors + peptides from NEOCUTIS
- Lightweight, silky texture absorbs quickly without residue
- Fragrance-free and gentle enough for sensitive skin
- Multi-tasking: firms, hydrates, brightens, and smooths in one step
- Excellent for neck and décolleté firming (not just face)
- Dermatologist-recommended and backed by clinical studies
- Layers well under makeup and other products
Criticized
- Premium price (~$275 for 30ml) puts it out of reach for many
- Small bottle runs out quickly with recommended twice-daily use (4–6 weeks)
- Some users report breakouts, particularly around the chin area
- Not vegan — contains human-derived growth factors (cutaneous lysate)
- Not fungal acne safe due to Polysorbate 60 and Sorbitan Isostearate
- Results require ongoing, consistent use — stopping reverses benefits
- Growth factor concentrations are proprietary (not disclosed)
Budget-friendly alternatives (dupes)
DUPESMulti-peptide formula with hyaluronic acid targets similar concerns (wrinkles, firmness). Lacks growth factors entirely, so anti-aging potency is significantly lower. Great entry-level peptide serum at a fraction of the price.
Contains niacinamide, peptides, and hyaluronic acid for firming and hydration. Drugstore price point but a cream formula (not serum), and lacks growth factor technology. Good for those wanting basic peptide benefits affordably.
Features barley-derived Epidermal Growth Factor (EGF) as the hero ingredient. Closer in concept with growth factor technology but plant-derived instead of human. Simpler formula without the peptide complex.
Comparison with competitors
SIDE-BY-SIDE
SkinMedica TNS Advanced+ Serum
SkinCeuticals C E Ferulic
Storage & shelf life
12 MONTHS12 months after opening
Store at room temperature in a cool, dry place. Avoid direct sunlight and extreme heat. Do not refrigerate unless directed.
Airless pump bottle — protects active ingredients from oxidation and ensures hygienic dispensing down to the last drop.
Yes, 30ml is under the 100ml TSA carry-on limit. Compact airless pump is leak-resistant.
Frequently asked questions
FAQBio Serum Firm does not contain retinoids, salicylic acid, hydroquinone, or chemical sunscreens — the most commonly flagged pregnancy-unsafe ingredients. However, it does contain human growth factors (cutaneous lysate), and there is insufficient clinical data on their safety during pregnancy and breastfeeding. NEOCUTIS does not provide official pregnancy safety guidance. We recommend consulting your OB-GYN or dermatologist before using this product while pregnant or nursing.
No. Bio Serum Firm contains Polysorbate 60 and Sorbitan Isostearate, both of which are known triggers for malassezia (the yeast responsible for fungal acne). If you are prone to fungal acne or pityrosporum folliculitis, this product is not recommended. Consider a fungal-acne-safe alternative without polysorbates or fatty acid esters.
Yes, Bio Serum Firm is generally compatible with retinol, vitamin C, and chemical exfoliants. It already contains a stabilized vitamin C derivative (Aminopropyl Ascorbyl Phosphate). For retinol: apply Bio Serum Firm in the morning and retinol at night, or alternate nights. For AHA/BHA: avoid layering directly on the same application — use acids first and allow them to absorb, or use on alternate nights to minimize irritation risk.
Bio Serum Firm is formulated for all skin types: normal, dry, oily, combination, sensitive, and mature. It is particularly well-suited for mature and aging skin concerned with loss of firmness, fine lines, wrinkles, and uneven texture. The lightweight, oil-free formula absorbs well on oily skin, while the dual hyaluronic acid and squalane provide sufficient hydration for dry skin (though very dry skin may need additional moisturizer).
Clinical studies show initial improvements in hydration, smoothness, and brightness can be noticed in as little as 6 days. More significant firming and wrinkle reduction typically become visible at 4–8 weeks of consistent twice-daily use. At 8 weeks, clinical data showed 94% improvement in texture, 92% in brightness, 88% in smoothness, and 77% in fine lines. Results continue to improve with long-term use over 3–6 months.
Apply Bio Serum Firm after cleansing (and toning, if applicable) but before moisturizer. In a morning routine: Cleanser → Toner → Bio Serum Firm → Moisturizer → Sunscreen. In an evening routine: Cleanser → Toner → Bio Serum Firm → Night Cream. If using other serums, apply Bio Serum Firm first as it is a treatment-level product, then layer lighter hydrating serums on top.
Bio Serum Firm is labeled non-comedogenic and dermatologist-tested. It scores a 1 out of 5 on the comedogenic scale, meaning it has a very low likelihood of clogging pores. The formula is oil-free, silicone-free, and free of heavy occlusives. However, a small number of users have reported breakouts (particularly hormonal acne around the chin), so individual results may vary. If you are acne-prone, patch test first.
The estimated Period After Opening (PAO) is 12 months. However, due to the presence of active growth factors and peptides, using the product within 6–8 months of opening is ideal for maximum potency. The airless pump packaging helps protect the formula from oxidation and contamination. With twice-daily use (2–3 pumps per application), the 30ml bottle typically lasts 4–6 weeks.
Verdict: NEOCUTIS Bio Serum Firm is one of the most scientifically advanced anti-aging serums available, combining the highest concentration of human growth factors with a triple peptide complex in a lightweight, elegant formula. Clinical data showing visible results in 6 days is compelling, and the 8-week study results across texture (94%), brightness (92%), and fine lines (77%) are impressive. The fragrance-free, non-comedogenic formula suits most skin types beautifully. The main drawback is the premium price point (~$275 for 30ml), which means the bottle runs out quickly with regular use. It's also not suitable for those with fungal acne. For those willing to invest in medical-grade anti-aging, this serum delivers on its promises and has earned a devoted following among dermatologists and mature-skin users alike.
Product Overview
Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.
Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.
Quick Product Notes
Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging «promises» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.
We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.
Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.
Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you
Notable Effects & Ingredients
Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.
We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.
A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.
One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!
Ingredients Related to Skin Types
Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.
EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.
Ingredient Safety Breakdown
Product ingredient list
| EWG | CIR | Ingredient Name & Cosmetic Functions | Notes |
|---|---|---|---|
| 1 |
Water
Solvent, Skin Conditioning
|
|
|
| 2 |
Glycerin
Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant, Skin Conditioning
|
Promotes Wound Healing
Hydrating
|
|
| 1 |
Caprylic/Capric Triglyceride
Solvent, Skin Conditioning, Masking, Perfuming, Emollient
|
|
|
| 0 |
Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Emulsion Stabilising
|
|
|
| 1 |
Squalane
Skin Conditioning, Emollient, Hair Conditioning, Refatting
|
Hydrating
|






