Clinical Strength Shampoo
Clinical Strength Shampoo
Product Description
Product overview
A clinically proven, prescription-strength anti-dandruff shampoo powered by 1% Selenium Sulfide. Targets stubborn dandruff and seborrheic dermatitis at the source by fighting Malassezia yeast 2x faster than ordinary dandruff shampoos. Gentle enough for daily use while delivering maximum flake, itch, and dryness relief.
Kills Malassezia 2x Faster
1% Selenium Sulfide eliminates more dandruff-causing Malassezia yeast in 3 washes compared to 6 washes with ordinary anti-dandruff shampoos.
Texture & feel
SENSORYKills Malassezia 2x Faster
1% Selenium Sulfide eliminates more dandruff-causing Malassezia yeast in 3 washes compared to 6 washes with ordinary anti-dandruff shampoos.
Prescription-Strength Formula
Delivers flake protection comparable to prescription 2% ketoconazole shampoo, available over-the-counter without a doctor visit.
Cooling Menthol Relief
Peppermint oil and menthol provide an immediate cooling sensation that soothes scalp itch and irritation on contact.
Multi-Symptom Relief
Addresses flakes, itching, irritation, scaling, redness, and dryness associated with both dandruff and seborrheic dermatitis in a single wash.
Safety & compatibility
SAFESelenium sulfide is FDA Pregnancy Category C. No controlled human studies exist. Manufacturers advise against use during pregnancy under ordinary circumstances.
Minimal skin absorption, but avoid applying near the chest area. Wash hands thoroughly after use. WHO considers it compatible with breastfeeding when used topically on the scalp.
Selenium sulfide actively fights Malassezia yeast, making this an excellent choice for those with fungal acne. The formula does not contain ferments, fatty acid esters, or polysorbates that feed Malassezia.
From the #1 dermatologist-recommended dandruff brand in America. Clinically proven efficacy in multiple studies. Gentle enough for regular use.
Selenium sulfide may discolor bleached, tinted, grey, or permed hair. Rinse for at least 5 minutes after use on chemically treated hair to minimize risk.
Safety and effectiveness in children under 2 years of age have not been established. Use only under a doctor's supervision for children under 12.
Ingredient breakdown
INGREDIENTSSelenium Sulfide 1%Proven
The star active ingredient — a potent antifungal and keratolytic agent that slows the growth of skin cells on the scalp and follicular epithelium, directly targeting the Malassezia yeast responsible for dandruff and seborrheic dermatitis.
- Mechanism: Acts as both an antifungal (kills Malassezia) and a cytostatic agent (slows excessive skin cell turnover on the scalp)
- Clinical Study: A randomized trial of 246 people showed a 67% reduction in dandruff score with 2.5% selenium sulfide vs. 45% with placebo over 29 days
- Efficacy: On the WHO List of Essential Medicines for treatment of seborrheic dermatitis and dandruff
Menthol + Peppermint Oil <1%Proven
A cooling duo that activates cold-sensitive receptors on the scalp to provide immediate itch relief. Peppermint oil (Mentha Piperita) also has mild antimicrobial properties that complement the antifungal action of selenium sulfide.
- Action: Menthol activates TRPM8 receptors, producing a cooling sensation that temporarily overrides itch signals
- Bonus: Peppermint oil stimulates scalp microcirculation, promoting a healthier scalp environment
Dimethicone ~1-2%Proven
A silicone-based conditioning agent that coats and smooths the hair shaft, reducing friction and adding shine. Counteracts the potential drying effects of medicated shampoos, leaving hair feeling soft and manageable after washing.
- Function: Forms a protective film on hair strands, reducing static, frizz, and tangling
- Benefit: Helps offset the stripping effect of strong surfactants used in medicated formulas
Sodium Lauryl Sulfate + Sodium Laureth SulfateFunctional
Primary surfactants responsible for the shampoo's rich, effective lather. They lift oil, dirt, and flakes from the scalp for thorough cleansing. SLS provides deep cleaning power while SLES adds mildness and foaming.
- Purpose: Essential for removing sebum buildup that feeds Malassezia yeast on the scalp
- Buffered: Cocamidopropyl Betaine is included as a co-surfactant to reduce potential irritation from SLS
18 ingredients
Active: Selenium Sulfide 1%. Inactive: Water, Sodium Lauryl Sulfate, Glycol Distearate, Sodium Chloride, Cocamidopropyl Betaine, Sodium Citrate, Sodium Xylenesulfonate, Dimethicone, Menthol, Fragrance, Citric Acid, Sodium Benzoate, Tetrasodium EDTA, Mentha Piperita (Peppermint) Flower/Leaf/Stem Oil, Mentha Arvensis Leaf/Stem Oil, Hydrogen Peroxide, Sodium Laureth Sulfate.
Where it fits in your routine
ROUTINEUse at least twice a week or as directed by a doctor. For maximum dandruff control, use every time you shampoo. Shake well before each use.
How to use
HOW TO USEShake & Wet
Shake the bottle well before use. Thoroughly wet your hair and scalp with warm water to open follicles and prepare for cleansing.
Lather & Massage
Apply a generous amount to wet hair. Massage into the scalp with fingertips for 1-2 minutes, working into a full lather. Focus on problem areas.
Let It Sit
Allow the lather to remain on your scalp for 2-3 minutes to let the selenium sulfide work on Malassezia yeast. You will feel a cooling menthol sensation.
Rinse Thoroughly
Rinse completely with warm water. Repeat if desired. For color-treated, bleached, or permed hair, rinse with cool water for at least 5 minutes.
Follow Up
Apply conditioner to mid-lengths and ends if needed. Wash hands well and clean under nails after use. Remove jewelry before shampooing to prevent discoloration.
Who is it for?
WHOPerfect for you if:
- You have moderate to severe dandruff that regular shampoos can't control
- You've been diagnosed with seborrheic dermatitis
- You experience persistent scalp itching, flaking, and redness
- You want prescription-strength treatment without a prescription
- You have an oily scalp with excess sebum buildup
- You suffer from fungal acne (Malassezia folliculitis) on the scalp
Consider alternatives if:
- You are pregnant or planning to become pregnant
- You have bleached, blonde, grey, or heavily color-treated hair
- You have only mild, occasional dandruff (regular H&S may suffice)
- You prefer sulfate-free or all-natural shampoo formulas
- You have extremely sensitive or broken/inflamed scalp skin
- You need a shampoo for children under 2 years old
Scalp type compatibility
SKIN TYPESStrong surfactants effectively cut through excess oil and sebum. Selenium sulfide targets the yeast that thrives in oily environments. Ideal match.
The Dry Scalp Rescue variant is formulated specifically for this concern. Dimethicone helps condition, but follow up with a moisturizing conditioner.
Contains SLS and menthol which may cause stinging on very sensitive or irritated scalps. Patch test first. Do not use on broken or inflamed skin.
Effective for preventive dandruff control. Can be used 2-3 times per week and alternated with a regular daily shampoo for best results.
Specifically indicated for seborrheic dermatitis. Relieves flaking, itching, irritation, scaling, and redness. Clinically proven effectiveness.
Results timeline
WEEK 4+Immediate Scalp Relief
Cooling menthol sensation soothes itching on contact. Scalp feels cleaner and lighter after the first use. Visible flakes are physically removed during lathering.
85% noticed itch reliefReduced Flaking & Itch
Selenium sulfide begins killing excess Malassezia yeast. Noticeable reduction in visible flakes on shoulders and clothing. Scalp itching becomes less frequent.
70% noticed fewer flakesSignificant Improvement
Stubborn dandruff patches begin clearing. Redness and scaling visibly reduced. Many users report their scalp feels "normal" for the first time in months.
80% reported major improvementFull Dandruff Control
Up to 100% protection against visible flakes with regular use. Seborrheic dermatitis symptoms well-managed. Can reduce frequency to maintenance level (1-2x per week).
90% achieved full controlRatings by platform
30K+ REVIEWSPros & cons
BALANCEDPraised
- Prescription-strength dandruff control without needing a doctor visit
- Works fast — many users see results within the first week
- Effective against both dandruff and seborrheic dermatitis
- Affordable compared to prescription ketoconazole shampoos
- Cooling menthol provides instant itch relief
- From the #1 dermatologist-recommended dandruff brand
- Gentle enough for daily use when needed
- Multiple variants (Itch Relief, Dry Scalp, Oil Control)
Criticized
- Strong medicinal scent that may linger after rinsing
- Can discolor light, grey, or color-treated hair
- Contains SLS — may be too stripping for very dry hair
- Not safe for use during pregnancy (FDA Category C)
- May cause initial stinging on irritated or broken skin
- Contains fragrance — not ideal for fragrance-sensitive users
- 13.5 oz bottle feels small for frequent use; runs out quickly
Budget-friendly alternatives (dupes)
DUPESAlso contains 1% selenium sulfide as the active ingredient. Very similar mechanism of action and efficacy. Stronger medicinal scent but often available at a lower price point. Lacks the dimethicone conditioning agent.
Walmart store brand with 1% selenium sulfide. Nearly identical active ingredient at a fraction of the price. Less refined fragrance and texture. No menthol or peppermint for itch relief.
Uses pyrithione zinc (1%) instead of selenium sulfide. Gentler and more moisturizing formula suitable for mild-moderate dandruff. Better for color-treated hair but less effective on stubborn cases.
Comparison with competitors
SIDE-BY-SIDE
Neutrogena T/Gel Therapeutic Shampoo
Storage & shelf life
12 MONTHS12 months after opening
Store at room temperature (68°F to 77°F / 20°C to 25°C). Keep away from excessive heat and moisture. Do not freeze. Shake well before each use.
Opaque plastic squeeze bottle with flip-top cap. Product may darken over time — this is normal and does not affect efficacy.
No — 13.5 fl oz exceeds the 3.4 oz / 100ml TSA carry-on limit. Transfer to a travel container or pack in checked luggage.
Frequently asked questions
FAQSelenium sulfide is classified as FDA Pregnancy Category C, and manufacturers advise against use during pregnancy. No controlled human studies exist, and animal reproduction studies have not been conducted. For breastfeeding, the WHO considers it compatible when used on the scalp since virtually no selenium sulfide is absorbed through intact skin. However, avoid applying near the chest area, wash hands thoroughly, and consult your doctor before using while nursing.
Yes — this shampoo is not only safe for fungal acne but actively fights the Malassezia yeast that causes it. Selenium sulfide is a proven antifungal agent. The formula does not contain common Malassezia-feeding ingredients like fatty acid esters, polysorbates, or fermented extracts. Many dermatologists recommend medicated selenium sulfide washes as a treatment for Malassezia folliculitis (fungal acne) on the face, chest, and back when used as a short-contact wash.
Since this is a rinse-off shampoo, it has minimal interaction with other skincare actives used on the face. You can safely use retinol, vitamin C, AHA, and BHA products in your skincare routine alongside this shampoo. If you use scalp-specific AHA or BHA treatments, alternate their application days with this shampoo to avoid over-drying or irritation. The menthol in this shampoo may temporarily increase sensitivity, so avoid applying strong acids to the scalp immediately after washing.
This shampoo is best suited for oily scalps and those with moderate to severe dandruff or seborrheic dermatitis. The strong surfactant system effectively cuts through excess oil and buildup. It also works well for normal scalps as a maintenance treatment. Those with very dry or extremely sensitive scalps should use with caution — consider the Dry Scalp Rescue variant or follow up with a moisturizing conditioner.
Most users notice itch relief from the first wash thanks to the cooling menthol. Visible flake reduction typically begins within the first week (2-3 washes). The brand claims it fights dandruff 2x faster than ordinary anti-dandruff shampoos, killing more Malassezia yeast in 3 washes vs. 6 with regular formulas. Full dandruff control with regular use is generally achieved within 2-4 weeks. For seborrheic dermatitis, two applications per week for two weeks is the standard initial treatment protocol.
Use it as your first step — in place of your regular shampoo. Apply to wet hair, massage into the scalp, leave on for 2-3 minutes, then rinse thoroughly. You may repeat if desired. Follow with a conditioner on mid-lengths and ends. For best results, use at least twice a week. On non-wash days or for in-between washes, you can use a gentler daily shampoo if needed.
No — this shampoo has a comedogenic rating of approximately 1 out of 5, meaning it is very unlikely to clog pores. Selenium sulfide itself is non-comedogenic. The dimethicone in the formula is a high-molecular-weight silicone that sits on the hair shaft rather than penetrating pores. Since this is a rinse-off product that stays on for only a few minutes, the risk of pore-clogging is minimal. If you are concerned about breakouts along the hairline, rinse thoroughly and wash your face after shampooing.
The shampoo has a shelf life of approximately 12 months after opening. Store at room temperature between 68°F and 77°F (20°C to 25°C), away from excessive heat and moisture. The product may darken in color over time, but this is normal and does not affect its safety or effectiveness. Always shake well before use and keep the cap tightly closed between uses.
Verdict: Head & Shoulders Clinical Strength Shampoo is one of the most effective over-the-counter dandruff treatments available, delivering prescription-grade results at a drugstore price. The 1% selenium sulfide formula genuinely works faster than standard pyrithione zinc shampoos, and it is one of the few OTC options clinically proven against seborrheic dermatitis. The main trade-offs are the strong scent, potential for hair discoloration on light or treated hair, and SLS-based surfactants that can be drying. It is not suitable for pregnancy. For anyone battling stubborn, persistent dandruff or scalp fungal issues, this is a strong, well-priced first-line treatment before resorting to prescription ketoconazole.
Product Overview
What are Quick Product Notes?
Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.
Pro Tip Alert!
Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.
Quick Product Notes
Paraben-Free
Paraben-Free
Understanding Parabens
Parabens are a large group of preservatives which are used to prevent bacteria growing in cosmetic formulations. There has been some healthy controversy surrounding them due to a few studies finding paraben presence in breast tumours and breast tissue. However, the majority of the scientific community have deemed these findings non-conclusive due to the limitations of these studies. There's still a lot of support for avoiding parabens following the better safe than sorry route. If you do we completely support you! If you are concerned about the health safety of parabens, then feel free to avoid them by looking out for the Paraben-Free icon. If not, don't worry about it - they do have had one of the longest safety records as preservatives!
Which Ingredients are classified as Paraben?
A product will be paraben-free if it does not contain any of the following parabens:
- Sodium Isobutylparaben
- Sodium Ethylparaben
- Sodium Butylparaben
- Propylparaben
- Isopropylparaben
- Isobutylparaben
- Sodium Propylparaben
- Butylparaben
- Ethylparaben
- Sodium Methylparaben
- Methylparaben
Sulfate-Free
Sulfate-Free
Understanding Sulfates
Sulfates are a large group of ingredients which act as cleansing agents in Cosmetics. They help loosen up the dirt and grime from your skin and hair to allow for water to wash it away with ease. However some sulfates are so good at their job, they can wash off your skin’s own natural oils that keep it moisturised and protected which can lead to dryness and irritation. Most people will find no issues with sulfate, however if you find your skin doesn't like sulfates then free feel to avoid them by looking out for the sulfate-free icon on Skincarisma.
Which ingredients are classified as sulfates?
We've taken the Sulfates which are considered more harsh for our Sulfate-Free status. A product will be Sulfate-Free if it does not contain any of the following Sulfates:
- TEA-Dodecylbenzenesulfonate
- Ammonium Laureth Sulfate
- Sodium Lauryl Sulfate
- PEG-15 Cocamine
- Sodium Laureth Sulfate
- Sodium Cocoyl Sarcosinate
- Sodium C14-16 Olefin Sulfonate
- Dioctyl Sodium Sulfosuccinate
- Ammonium Xylenesulfonate
- Ammonium Lauryl Sulfate
- Sodium Xylenesulfonate
- Sodium Myreth Sulfate
- Sodium Lauryl Sulfoacetate
Alcohol-Free
Alcohol-Free
Understanding Simple Alcohols
Alcohol ingredients are widely used in cosmetics and come in different types. For the most part alcohols are not problematic at all. However one type of alcohols, simple alcohols can be quite drying to the skin because it evaporates very quickly. This can cause irritation which can also lead to other skin complications. These alcohols should never be used alone on your skin, but combined with other cosmetic ingredients, they are normally without issue. However, for some people with sensitive and easily irritable skin, avoiding products with these simple alcohols may be beneficial. If you find your skin doesn't like these simple alcohols, then free feel to avoid them by looking out for the Alcohol-Free icon.
Which Ingredients are classified as Alcohol?
A product will be alcohol-free if it does not contain any of the following alcohol ingredients:
- SD Alcohol
- Alcohol Denat
- Isopropyl Alcohol
- Alcohol
Silicone-Free
Silicone-Free
Understanding Silicones
If you've ever used a skincare, makeup or beauty product that's made your skin look and feel smoother tempoarily - it's likely contained Silicone. They are a popular class of ingredients found in cosmetics due to their smooth, soft, easy-to-spread and smooth properties that help creates an artificial layer/barrier on top of skin or hair (commonly found in conditioners).
For the same reasons they are popularly used, they are also commonly avoided. Anecdotally, many individuals have reported that Silicones cause/excerbate breakouts, irritation, cause a feeling of skin being unable to breathe, cause clumping of cosmetic products and find it difficult to wash off. As a result, those who find them problematic are avoiding them and increasingly, cosmetic companies are avoiding them as well.
If you have had bad experiences with Silicones in the past, or suspect they are problematic then look out for the tick on the Silicone-free label.
Disclaimer
The Silicone-free label only includes the most common Silicone ingredients that have indentified been reported by individuals that could potentially cause issues.
These include: Amodimethicone, Behenoxy Dimethicone, Bis-Aminopropyl Dimethicone, Cetearyl Methicone, Cetyl Dimethicone, Cyclomethicone, Cyclopentasiloxane, Dimethicone, Dimethicone Copolyol, Dimethiconol, Methicone, Phenyl Trimethicone, Phenyl Trimethicone, Stearoxy Dimethicone, Stearyl Dimethicone, Trimethylsilylamodimethicone.
Note, that this does not include all ingredients part of the Silicone class of ingredients.
EU Allergen-Free
EU Allergen-Free
Understanding the Identified Contact Allergens
The EU's Scientific Committee on Consumer Safety (SCCS) has identified and established 26 cosmetic ingredients that are likely contact allergens (potential to cause skin allergies) as demonstrated in clinical or epidemiological studies. The EU's SCCS have recommend cosmetic companies to disclose them on the labels if used and in cases where the concentration exceeds 0.001% in leave-on products and 0.01% in rinse-off products, then they must be labelled.
Look out for the tick on the EU-Allergen free label to know your cosmetic is free from any of the 26 identified cosmetic ingredients.
For more information regarding the EU's Scientific Committee on Consumer Safety, please visit their official website.
Disclaimer
The EU Allergen Free label is for the 26 ingredients identified by the EU SCCS and products will be only flagged if a suspected ingredient is on it's ingredient list. It is possible for cosmetics to contain one of the suspect ingredients without it appearing on the ingredient list due to it not reaching the concentration threshold to disclose it and cosmetic manufacturers choice to not disclose it.
Also note, the EU Allergen Free label is not personalized for your own allergies you may have and it does not constitute as medical advice. For your specific case, always consult your medical professiona such as dermatologist, physician, pharmacist, or health care provider - please read our medical disclaimer for more information.
Fungal Acne (Molassezia) Safe
Fungal Acne (Molassezia) Safe
Understanding Fungal Acne (Pityrosporum Folliculitis/Malassezia Folliculitis)
Pityrosporum Folliculitis/Malassezia folliculitis or simply known as Fungal Acne is a persistent acne-like condition that commonly responds poorly to traditional acne-treating methods. Unlike most cases of Acne where bacteria is the culprit, Fungi is the culprit of Fungal Acne (Hence the name!). There are certain classes & groups of ingredients that have been shown to promote and feed the growth of the Fungal Acne, Fungi such as fatty acids, oils, esters, polysorbates and fermented ingredients.
For more information regarding Fungal Acne, please visit Simple Skincare Science (f.c) - #3 of our Recommend Skincare Resources for an amazing comprehensive guide!
Please Read: How to use the Fungal Acne (Malassezia) Label
At SkinCarisma, we've done our best to identify as many ingredients as possible but note the fungal-free label may not be 100% accurate due to the complexconditions and combination of ingredients that malezzeria can thrive on.
Additionally, products that may contain ingredients that have shown to feed Malassezia may not neccessarily exacerbate the condition due to concentration of ingredient used in the product, this information is simply not available on the products.
As a result, please note this is only an experimental label that can be best used to possible identify problematic products you have used in the past. It is in no way a perfect identifier nor a predictor in whether or not it will exacerbate or cause fungal acne. It will continue to be worked on as more information and research comes to light.
If you find any ingredients you believe should be included, please email us at snails@skincarisma.com.
Disclaimer
Due to the lack of substantial research into this area it is very likely there are other ingredients and class/groups of ingredients that could feed Fungal Acne which have not been indentified.
The Fungal-Safe label does not constitute as medical advice. For your specific case, always consult your medical professiona such as dermatologist, physician, pharmacist, or health care provider - please read our medical disclaimer for more information.
What are Notable Effects & Ingredients?
Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging «promises» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.
We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.
Pro Tip Alert!
Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.
Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you
Notable Effects & Ingredients
Anti-Aging from 1 ingredient(s):
Brightening from 1 ingredient(s):
Promotes Wound Healing from 1 ingredient(s):
What are Ingredients Related to Skin Type?
Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.
We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.
Pro Tip Alert!
A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.
One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!
Ingredients Related to Skin Types
Dry Skin
Oily/Acne-Prone Skin
Sensitive Skin
What is the Ingredient Safety Breakdown?
Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.
Pro Tip Alert!
EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.
Ingredient Safety Breakdown
Product ingredient list
| EWG | CIR | Ingredient Name & Cosmetic Functions | Notes |
|---|---|---|---|
| 0 |
Selenium Sulfide
|
|
|
| 1 |
Water
Solvent, Skin Conditioning
|
|
|
| 0 |
Ammonium Laureth Sulfate
Cleansing, Foaming
|
|
|
| 1 |
Ammonium Lauryl Sulfate
Surfactant, Cleansing, Foaming
|
|
|
| 1 |
Glycol Distearate
Skin Conditioning, Emollient, Viscosity Controlling, Viscosity Increasing Agent, Emulsifying, Opacifying
|
|