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Effaclar H Iso-Biome Cleansing Cream

Effaclar H Iso-Biome Cleansing Cream

Product Description

Product overview

Made in France FRENCH BEAUTY

A soothing, hydrating cream cleanser specifically formulated for acne-prone skin weakened by drying treatments like isotretinoin. Enriched with Niacinamide, Shea Butter, and La Roche-Posay's exclusive Aqua Posae Filiformis prebiotic to gently cleanse while restoring the skin's microbiome balance.

Dermatologist Tested Non-Comedogenic Physiological pH Isotretinoin Compatible Microbiome Science Paraben-Free
Pregnancy
Yes
Fungal Acne
No
Comedogenic
1/5
Size
200ml / 390ml
Skin Type
Oily, Acne-Prone
Formula
Cream-Gel
pH Level
Physiological
Key Active
Niacinamide
Real reviews · YouTube Shorts
Why it's different

Microbiome Science

Contains Aqua Posae Filiformis, a prebiotic exclusive to La Roche-Posay that helps rebalance the skin's microbiome and strengthen the barrier.

01

Texture & feel

SENSORY
Consistency
Cream-Gel
Scent
Light, Clean
Absorption
Rinse-Off
Finish
Soft, Hydrated

Microbiome Science

Contains Aqua Posae Filiformis, a prebiotic exclusive to La Roche-Posay that helps rebalance the skin's microbiome and strengthen the barrier.

Treatment Compatible

Tested and proven safe for use alongside drying acne treatments including oral isotretinoin (Accutane), retinoids, and benzoyl peroxide.

Soothing Formula

Enriched with Shea Butter, Glycerin, and Niacinamide to calm irritation, reduce redness, and restore comfort to compromised skin.

Anti-Imperfection

Bixa Orellana (Annatto) Seed Extract helps reduce imperfections and marks while maintaining optimal hydration levels.

02

Safety & compatibility

SAFE
Pregnancy & Breastfeeding Safe

Free from retinoids, high-concentration salicylic acid, and other pregnancy-contraindicated ingredients. Safe for use during pregnancy and breastfeeding.

Not Fungal Acne Safe

Contains Polysorbate 20, PEG-200 Hydrogenated Glyceryl Palmate, Shea Butter, and Glycol Distearate which may feed Malassezia yeast.

Low Comedogenic Rating

Formulated to be non-comedogenic. As a rinse-off product, potentially comedogenic ingredients have minimal pore-clogging risk.

Contains Fragrance

Contains Parfum/Fragrance. Those with extreme sensitivity or fragrance allergies should patch test first.

Isotretinoin Compatible

Clinically tested for use alongside oral isotretinoin treatment. Helps counteract the drying side effects of Accutane.

Contains SLES

Contains Sodium Laureth Sulfate (SLES) - a mild surfactant. Though gentler than SLS, those seeking sulfate-free options should consider alternatives.

03

Ingredient breakdown

INGREDIENTS

Niacinamide (Vitamin B3)Proven

A powerhouse ingredient that brightens skin, reduces redness, minimizes pores, and strengthens the skin barrier. Helps regulate sebum production and reduce acne-related inflammation.

  • Benefits: Anti-inflammatory, brightening, pore-minimizing, barrier-strengthening
  • Research: Multiple studies confirm efficacy at 2-5% concentration for acne and redness reduction
  • Synergy: Works well with most other skincare actives including retinoids
Well-tolerated by sensitive skin. Can be used morning and evening.

Vitreoscilla Ferment (Aqua Posae Filiformis)Proven

La Roche-Posay's patented prebiotic biomass derived from their thermal spring water. Helps restore the skin's microbiome balance and strengthen the protective barrier.

  • Benefits: Microbiome support, anti-inflammatory, barrier repair
  • Research: Proprietary LRP ingredient clinically proven to support skin barrier function
  • Best for: Compromised, sensitized, or treatment-damaged skin

Shea Butter (Butyrospermum Parkii Butter)Proven

Rich emollient that provides deep nourishment and helps repair the skin's moisture barrier. Particularly beneficial for skin dried out by acne treatments.

  • Benefits: Moisturizing, anti-inflammatory, healing
  • Components: Vitamins A, E, F + essential fatty acids
  • Note: In a wash-off formula, comedogenic concerns are minimized

Bixa Orellana Seed Extract (Annatto)Promising

A botanical extract with antioxidant and anti-inflammatory properties. Helps reduce imperfections and supports skin healing without compromising hydration.

  • Benefits: Anti-imperfection, antioxidant, soothing
  • Traditional use: Long history in wound healing and skin protection

GlycerinProven

A gold-standard humectant that attracts and retains moisture in the skin. Naturally present in skin and extremely well-tolerated by all skin types.

  • Benefits: Hydrating, skin-identical, barrier supporting
  • Comedogenic rating: 0 - will not clog pores
  • Concentration: Effective from 3% upward

23 ingredients

Aqua/Water, Glycerin, Sodium Laureth Sulfate, PEG-200 Hydrogenated Glyceryl Palmate, Coco-Betaine, Polysorbate 20, Citric Acid, PEG-7 Glyceryl Cocoate, Niacinamide, Bixa Orellana Seed Extract, Butyrospermum Parkii Butter (Shea Butter), Cocamide MEA, Glycol Distearate, Sodium Chloride, Sodium Hydroxide, Mannose, Disodium EDTA, Vitreoscilla Ferment, Maltodextrin, Polyquaternium-11, Acrylates Copolymer, Sodium Benzoate, Parfum/Fragrance

FREE FROM: Parabens, Silicones, Oils, Harsh Alcohols, Common Allergens, SLS (contains gentler SLES)
04

Where it fits in your routine

ROUTINE
1
This Product
2
Toner
3
Serum
4
Treatment
5
Moisturizer
6
Sunscreen (AM)

Use as your primary cleanser morning and evening. Can be used alone or as a second cleanse after an oil cleanser for double cleansing. Pairs perfectly with Effaclar H Iso-Biome Moisturizer.

05

How to use

HOW TO USE
1

Wet Your Face

Splash lukewarm water on your face. Avoid hot water which can strip the skin and increase sensitivity.

2

Lather in Hands

Dispense a small amount (about a pump) into wet hands and create a gentle lather with water.

3

Massage Gently

Apply to damp face using fingertips, starting between eyebrows to hairline, then spreading outward in circular motions. Include neck if desired.

4

Rinse Thoroughly

Rinse completely with lukewarm water. Pat dry with a clean, soft towel - avoid rubbing sensitive skin.

5

Follow with Care

Immediately follow with your toner, treatment products, and moisturizer while skin is still slightly damp for best absorption.

06

Who is it for?

WHO

Perfect for you if:

  • You're on isotretinoin (Accutane) or other drying acne treatments
  • Your skin feels tight, dry, or irritated from actives
  • You have sensitive, acne-prone skin
  • You need a gentle cleanser that won't strip your barrier
  • You're looking for microbiome-supportive skincare
  • You want to reduce redness and calm inflammation
  • You're pregnant or breastfeeding with breakout-prone skin

Consider alternatives if:

  • You have fungal acne (Malassezia folliculitis)
  • You need a fragrance-free product (contains Parfum)
  • You prefer completely sulfate-free cleansers
  • You want a deep-cleansing, oil-controlling formula
  • You have very oily skin without sensitivity issues
  • You're looking for an exfoliating cleanser
07

Skin type compatibility

SKIN TYPES
Oily Skin
Good

Cleanses effectively without over-stripping. Best for oily skin compromised by treatments. Very oily skin without sensitivity may prefer deeper-cleansing options.

Dry Skin
Excellent

Hydrating formula leaves skin comfortable, not tight. Shea Butter and Glycerin help maintain moisture levels during cleansing.

Combination Skin
Excellent

Balances cleansing and hydration perfectly for combination skin. Won't dry out dry areas or leave oily zones feeling greasy.

Sensitive Skin
Excellent

Specifically formulated for sensitized skin. 97% of dermatologists rated tolerance as "very good" in clinical studies.

Acne-Prone Skin
Excellent

Non-comedogenic, dermatologist-tested formula. Ideal for acne-prone skin on treatments. Clinical study showed 88.9% improvement in acne scores.

08

Results timeline

WEEK 12+
Day 1

Immediate Comfort

Skin feels clean, soft, and comfortably hydrated. No tightness or dryness after cleansing. Reduced stinging sensations for sensitized skin.

95% noticed reduced discomfort
Week 1-2

Reduced Irritation

Visible reduction in redness and irritation. Skin barrier begins to recover. Treatment side effects like flaking and tightness diminish.

90% reported reduced dryness
Week 4-8

Improved Skin Quality

Skin microbiome more balanced. Noticeable improvement in overall skin texture and resilience. Better tolerance to acne treatments.

88.9% showed improved acne scores
Week 12+

Optimal Results

Full benefits realized. Strengthened skin barrier, balanced hydration, reduced imperfections, and improved treatment efficacy.

94% overall patient satisfaction
09

Ratings by platform

1K+ REVIEWS
La Roche-Posay UK
2.6
Rating
74
Reviews
Main complaint: Mixed results - some find it drying despite hydrating claims
Cocooncenter
★★★★½ 4.5
Rating
192
Reviews
Main complaint: Contains fragrance which bothers some sensitive users
Influenster
4.2
Rating
500+
Reviews
Main complaint: Price point higher than drugstore alternatives
Amazon EU
4.3
Rating
1,200+
Reviews
Main complaint: Some users experienced breakouts initially
10

Pros & cons

BALANCED

Praised

  • Excellent for skin on isotretinoin/Accutane
  • Doesn't leave skin tight or stripped
  • Gentle enough for twice-daily use
  • Reduces redness and irritation
  • Dermatologist-developed formula
  • Clinically proven efficacy
  • Microbiome-supportive technology
  • A little product goes a long way

Criticized

  • Contains fragrance (potential irritant)
  • Not fungal acne safe
  • Contains SLES (not sulfate-free)
  • Mixed reviews on some platforms
  • Can cause breakouts for some users initially
  • Higher price than basic drugstore cleansers
  • May not be cleansing enough for very oily skin
11

Budget-friendly alternatives (dupes)

DUPES
59% Match
Cleanance Hydra Soothing Cleansing Cream
$14.00
Similar Price

Same purpose: skin on drying acne treatments. Contains Avène Thermal Water instead of LRP's prebiotic. More minimal ingredient list, no sulfates. Best for extremely sensitive skin.

65% Match
Hydrating Facial Cleanser
$10.99
Budget Pick

Contains ceramides and hyaluronic acid for hydration. Fragrance-free option. Less focused on acne-treatment compatibility but excellent for sensitive, dry skin. Better value per ml.

55% Match
Sensibio Gel Moussant
$12.50
Budget Pick

Micellar technology for gentle cleansing. Fragrance-free and soap-free. Better suited for general sensitive skin than specifically acne-treatment-damaged skin.

50% Match
Toleriane Hydrating Gentle Cleanser
$15.99
Same Brand

Same brand, different line. Contains ceramides and niacinamide. Fragrance-free. Better for general sensitive skin but lacks the acne-specific and microbiome benefits.

12

Comparison with competitors

SIDE-BY-SIDE
Cleanance Hydra Soothing Cream
Key Technology Avène Thermal Water
Size 200ml
Isotretinoin Tested Yes
Fragrance Fragrance-Free
Fungal Acne Safe Partial
Hydrating Cleanser
Key Technology 3 Essential Ceramides
Size 237ml (Better Value)
Isotretinoin Tested Not Specific
Fragrance Fragrance-Free
Fungal Acne Safe No
Sensibio Gel Moussant
Key Technology Micellar Technology
Size 200ml
Isotretinoin Tested Not Specific
Fragrance Fragrance-Free
Fungal Acne Safe Partial
13

Storage & shelf life

12 MONTHS
Period After Opening (PAO)

12 months after opening

Storage

Store in a cool, dry place away from direct sunlight. Keep at room temperature (15-25°C / 59-77°F).

Packaging

Plastic tube with flip-top cap. 200ml standard size, 390ml jumbo size available.

Travel Friendly

200ml exceeds 100ml carry-on limit. Purchase travel size or decant for air travel.

13

Frequently asked questions

FAQ

Yes, this cleanser is considered safe for pregnancy and breastfeeding. It does not contain retinoids, high-concentration salicylic acid, hydroquinone, or chemical sunscreens - the main ingredients to avoid during pregnancy. The formula focuses on gentle, hydrating ingredients like Niacinamide, Glycerin, and Shea Butter which are all pregnancy-safe. Always consult your healthcare provider if you have specific concerns.

No, this product is NOT fungal acne safe. It contains several ingredients that can feed Malassezia yeast including: Polysorbate 20, PEG-200 Hydrogenated Glyceryl Palmate, PEG-7 Glyceryl Cocoate, Glycol Distearate, and Butyrospermum Parkii Butter (Shea Butter). If you have fungal acne, consider alternatives like La Roche-Posay Toleriane Hydrating Gentle Cleanser or a specifically FA-safe cleanser.

Yes! This cleanser is specifically designed for skin using active treatments. It's tested and compatible with isotretinoin, prescription retinoids, over-the-counter retinol, vitamin C, and chemical exfoliants (AHA/BHA). The hydrating formula helps counteract the drying effects of these actives. Just ensure you're not over-exfoliating - the cleanser helps support your skin while actives do their work.

This cleanser is ideal for: (1) Acne-prone skin on drying treatments like isotretinoin, retinoids, or benzoyl peroxide; (2) Sensitive, compromised, or reactive skin; (3) Combination to dry skin types; (4) Skin with damaged barriers needing gentle cleansing. It may not be ideal for very oily skin without sensitivity issues, as it's designed for hydration rather than deep oil control.

Results timeline: Immediate (Day 1) - skin feels comfortable, hydrated, not tight after cleansing. Week 1-2 - visible reduction in redness and irritation, decreased treatment side effects. Week 4-8 - improved skin texture and barrier function. Week 12+ - optimal results with balanced microbiome and strengthened barrier. A clinical study of 306 patients showed 88.9% improvement in acne scores after 12 weeks of use alongside acne treatments.

This is a cleanser, so it's Step 1 of your routine. Use morning and evening on damp skin, massage gently, then rinse thoroughly. Follow with your toner, serums, treatments, moisturizer, and sunscreen (AM only). It can be used alone or as the second cleanser in a double-cleansing routine after an oil-based cleanser to remove makeup and sunscreen.

This product is formulated to be non-comedogenic and is labeled as such by La Roche-Posay. While it contains some potentially comedogenic ingredients like Shea Butter (rating 0-2), because it's a rinse-off product, these ingredients don't stay on your skin long enough to clog pores. The overall comedogenic rating is estimated at 1/5 - very low risk of clogging pores. It's dermatologist-tested specifically for acne-prone skin.

The Period After Opening (PAO) is 12 months. Once opened, use within 12 months for best efficacy and safety. Store in a cool, dry place away from direct sunlight and extreme temperatures. The 200ml tube typically lasts 2-3 months with twice-daily use, well within the PAO limit. Check the packaging for the PAO symbol (open jar icon) with "12M" indicated.

— Skincarisma verdict
4.0 / 5 ★★★★☆

Verdict: La Roche-Posay Effaclar H Iso-Biome Cleansing Cream is an excellent choice for anyone with acne-prone skin undergoing drying treatments. Its unique prebiotic technology, combined with soothing Niacinamide and Shea Butter, makes it stand out from typical gentle cleansers. While it's not suitable for fungal acne sufferers and contains fragrance, its clinically-proven efficacy (88.9% improvement in acne scores) and dermatologist-developed formula make it a worthy investment. Particularly recommended for isotretinoin users seeking a gentle yet effective cleanser that won't compromise their treatment results.

Product Overview

question
lightbulb What are Quick Product Notes?

Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.

muscle Pro Tip Alert!

Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.

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Quick Product Notes

Click on icons for more information
question
lightbulb What are Notable Effects & Ingredients?

Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging «promises» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.

We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.

muscle Pro Tip Alert!

Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.

Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you

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Notable Effects & Ingredients

anti-aging Anti-Aging from 2 ingredient(s):
Citric Acid Niacinamide
brightening Brightening from 3 ingredient(s):
Glycerin Citric Acid Niacinamide
wound Promotes Wound Healing from 3 ingredient(s):
Glycerin Citric Acid Niacinamide
ache Ache-fighting from 1 ingredient(s):
Niacinamide
question
lightbulb What are Ingredients Related to Skin Type?

Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.

We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.

muscle Pro Tip Alert!

A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.

One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!

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Ingredients Related to Skin Types

Click on icons for more information
dry-skin Dry Skin
1
oily-skin Oily/Acne-Prone Skin
2
sensitive-skin Sensitive Skin
question
lightbulb What is the Ingredient Safety Breakdown?

Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.

muscle Pro Tip Alert!

EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.

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Ingredient Safety Breakdown

EWG Health Ratings
Low risk
Medium risk
High risk
Unknown risk
54% 22% 22%

Product ingredient list

Showing first 5 of 22 ingredients
EWG CIR Ingredient Name & Cosmetic Functions Notes
1 Unknown
Water
Solvent, Skin Conditioning
2 A
Glycerin
Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant, Skin Conditioning
brightening Brightening
Promotes Wound Healing
Hydrating
3 Unknown
Sodium Laureth Sulfate
Surfactant, Emulsifying, Cleansing, Foaming
3 Unknown
PEG-200 Hydrogenated Glyceryl Palmate
Solvent, Surfactant, Emulsifying, Cleansing
1 B
Coco-Betaine
Skin Conditioning, Viscosity Controlling, Viscosity Increasing Agent, Antistatic Agent, Hair Conditioning, Sufactant, Foam Boosting
VIEW ALL INGREDIENTS