L-Glutathione Flexible Liposome
L-Glutathione Flexible Liposome
Product Description
A high-potency brightening ampoule featuring 5% liposomal L-Glutathione (88 billion molecules/mL) with flexible liposome technology for deep skin penetration. Combined with Niacinamide, Tranexamic Acid, and Vitamin E to target dark spots, uneven skin tone, and hyperpigmentation while supporting skin barrier health.
โจ Texture & Feel
Flexible Liposome Technology
Encapsulates glutathione in hydrogenated lecithin and cholesterol liposomes for enhanced skin penetration and stability.
High-Potency Brightening
Contains 5% pure L-Glutathione (50,000ppm) to inhibit melanin production and reduce hyperpigmentation.
Multi-Action Formula
Synergistic blend of Niacinamide, Tranexamic Acid, and Vitamin E for comprehensive skin tone correction.
Barrier Support
Glycerin, Betaine, and Panthenol provide hydration while Licorice Root Extract (Dipotassium Glycyrrhizate) soothes and calms.
๐ก๏ธ Safety & Compatibility
Limited research on topical glutathione during pregnancy. Contains no retinoids or hydroquinone. Consult your healthcare provider before use.
Contains Hydrogenated Lecithin which may be a concern for some FA-prone skin. Patch test recommended if you have malassezia sensitivity.
Dermatologist-tested formula. Free from fragrances, parabens, sulfates, and harsh alcohols. Most users report no irritation.
Can be layered with other actives. Apply this serum first as a booster, then follow with your treatment serums.
Natural sulfurous smell from glutathione (similar to eggs). This is normal and indicates active ingredient potency. Scent dissipates quickly after application.
Oil-free, silicone-free formula with a comedogenic rating of 1/5. Unlikely to clog pores for most skin types.
๐ฌ Ingredient Breakdown
โก L-Glutathione 5% (50,000ppm) Star Ingredient
A powerful tripeptide antioxidant naturally produced in the body. Inhibits tyrosinase enzyme to reduce melanin production, providing skin brightening and anti-aging benefits.
- Function: Master antioxidant, melanin inhibitor, free radical scavenger
- Research: Studies show glutathione can help protect skin from UV-B induced damage and reduce oxidative stress
- Delivery: Encapsulated in flexible liposomes for enhanced penetration
๐ Niacinamide (Vitamin B3) Proven
Multitasking powerhouse that strengthens skin barrier, reduces pores and dark spots, regulates oil production, and improves signs of aging.
- Benefits: Brightening, barrier repair, oil control, anti-aging
- Synergy: Works synergistically with glutathione to enhance brightening effects
- Safety: Well-tolerated by most skin types including sensitive skin
๐ Tranexamic Acid Proven
Clinically proven ingredient that targets stubborn hyperpigmentation and melasma by inhibiting the pathway that leads to melanin production.
- Research: Multiple studies show effectiveness for melasma and post-inflammatory hyperpigmentation
- Safety: Generally considered safe for topical use, gentler alternative to hydroquinone
- Action: Blocks plasmin activity to prevent UV-induced pigmentation
๐งฌ Liposome Complex Delivery System
Advanced delivery technology using Hydrogenated Lecithin and Cholesterol to encapsulate active ingredients for deeper skin penetration.
- Hydrogenated Lecithin: Creates flexible liposome structure for enhanced absorption
- Cholesterol: Skin-identical lipid that strengthens barrier and stabilizes liposomes
- Benefit: Improves bioavailability of glutathione and other actives
๐ฟ Supporting Ingredients Soothing & Hydrating
Carefully selected ingredients to hydrate, soothe, and support overall skin health.
- Panthenol (Vitamin B5): Hydrates and promotes wound healing
- Tocopherol (Vitamin E): Antioxidant protection and moisture retention
- Dipotassium Glycyrrhizate: Licorice root extract for soothing and anti-inflammatory benefits
- Betaine: Natural humectant for hydration
- Cysteine & Glycine: Amino acids that support glutathione synthesis
21 ingredients
Water, Butylene Glycol, Glycerin, Glutathione (50,000ppm), 1,2-Hexanediol, Niacinamide, Tranexamic Acid, Cysteine, Glycine, Tocopherol, Betaine, Panthenol, Carnitine, Ethylhexylglycerin, Sodium Citrate, Citric Acid, Hydrogenated Lecithin, Cholesterol, Dipotassium Glycyrrhizate, Sodium Cocoyl Isethionate, Xanthan Gum
๐ Where It Fits in Your Routine
๐ก Apply immediately after cleansing on bare, dry skin for best absorption. This product acts as a booster to enhance the efficacy of your following skincare steps.
๐ How to Use
Cleanse Your Face
Start with a clean, dry face. Pat skin dry completely - this product works best on dry skin for optimal absorption.
Dispense Product
Pump 2-3 drops onto your fingertips or palm. A little goes a long way due to the concentrated formula.
Apply & Pat
Gently apply to entire face, patting lightly to aid absorption. Focus on areas with dark spots or uneven tone.
Wait & Continue
Allow 1-2 minutes for complete absorption before applying toner and other products. Use morning and/or night.
๐ค Who Is It For?
โ Perfect for you if:
- You have dark spots, hyperpigmentation, or melasma
- Your skin looks dull and lacks radiance
- You want a brightening product without hydroquinone
- You prefer lightweight, fast-absorbing textures
- You want to enhance absorption of other products
- You have acne scars or post-inflammatory pigmentation
โ Consider alternatives if:
- You are highly sensitive to sulfurous smells
- You have active fungal acne and are sensitive to lecithin
- You are pregnant/breastfeeding (consult doctor first)
- You need a product that also provides heavy moisture
- You expect overnight dramatic results
๐ฏ Skin Type Compatibility
Watery, oil-free formula absorbs instantly without adding shine or greasiness. Niacinamide helps regulate sebum.
Provides light hydration but will need a heavier moisturizer on top. Glycerin and Betaine offer some moisture.
Lightweight texture works well across different face zones. Balances oily T-zone without drying cheeks.
Dermatologist-tested and fragrance-free. Some may experience mild tingling initially. Patch test recommended.
Non-comedogenic (1/5), oil-free formula. Great for fading acne scars. Check lecithin sensitivity if fungal acne prone.
๐ Results Timeline
Hydration & Glow Boost
Skin feels more hydrated and looks more luminous. Some users notice an immediate radiance boost after application.
70% noticed improved glowTone Evening Begins
Overall complexion starts to look clearer and more even. Dullness decreases noticeably. Skin texture may feel smoother.
65% saw clearer complexionVisible Brightening
Dark spots and hyperpigmentation start to fade. Users report noticeable difference between treated and untreated areas.
60% noticed spot reductionContinued Improvement
With consistent use, skin tone becomes more uniform. Best results seen with continued daily use alongside sun protection.
55% achieved desired resultsโญ Ratings by Platform
โ๏ธ Pros & Cons
โ Praised
- High concentration of glutathione (5%) with liposome delivery
- Noticeable brightening effect within weeks
- Lightweight, fast-absorbing watery texture
- Clean formula free from harmful ingredients
- Dermatologist tested for sensitive skin
- Enhances absorption of other skincare products
- Airless pump preserves formula integrity
- Layers well under makeup and other products
โ Criticized
- Strong sulfurous/egg smell (glutathione characteristic)
- Small bottle (30ml) runs out quickly with daily use
- Results vary significantly between individuals
- Some users experience initial breakouts (purging)
- Not moisturizing enough for very dry skin alone
- Can feel slightly sticky before fully absorbed
- Higher price point compared to basic serums
๐ฐ Budget-Friendly Alternatives (Dupes)
Contains glutathione with liposome technology plus Vitamin C. Larger 50ml size but lower glutathione concentration. More ingredients including centella and ceramides.
Different active (alpha arbutin) but same brightening goal. Much more affordable. No glutathione or liposome technology, but proven melanin inhibitor.
Focuses on Vitamin C and fermented ingredients for brightening. No glutathione but includes niacinamide. Better value but different mechanism of action.
Contains glutathione with high-concentration Vitamin C (25%). More expensive but stronger antioxidant protection. Better for mature skin concerns.
๐ Comparison with Competitors
PURCELL L-Glutathione (This Product)
$28-35Abib Glutathiosome Dark Spot Serum
$26Paula's Choice Vitamin C + Glutathione
$55The Ordinary Alpha Arbutin 2%
$9.90๐ฆ Storage & Shelf Life
12 months after opening
Store in a cool, dry place away from direct sunlight. Refrigeration optional but can help preserve potency.
Airless pump bottle that protects formula from oxidation and contamination
Yes, 30ml is under 100ml TSA limit for carry-on luggage
โ Frequently Asked Questions
There is limited research on topical glutathione during pregnancy and breastfeeding. While glutathione is naturally present in the body and the formula contains no known harmful ingredients (no retinoids, hydroquinone, or chemical sunscreens), we recommend consulting your healthcare provider before use during pregnancy or while nursing.
This product contains Hydrogenated Lecithin as part of its liposome delivery system, which may be a concern for some individuals with fungal acne sensitivity. While the formula is oil-free and free from common FA triggers like fatty acids and esters, those with severe malassezia should patch test first or consult a dermatologist.
Yes, this serum can be layered with other actives. Apply PURCELL first on clean, dry skin as a booster, then follow with your other serums. When using with retinol or strong acids, you may want to use them at different times of day (glutathione AM, retinol PM) to minimize potential irritation.
This serum is best for oily, combination, and normal skin types due to its lightweight, watery texture. Dry skin types can use it but will need a heavier moisturizer. It's excellent for anyone dealing with dullness, dark spots, uneven skin tone, or hyperpigmentation. The dermatologist-tested formula is also suitable for sensitive skin.
Most users notice improved radiance and glow within 1-2 weeks. Visible brightening and reduction in dark spots typically begin around weeks 3-4, with more significant results at 6-8 weeks of consistent use. Results vary by individual - some respond better to glutathione than others. Always use sunscreen during the day for best results.
Apply immediately after cleansing on bare, dry skin - before toner. This is unusual compared to most serums, but the manufacturer recommends this order for optimal absorption. The product acts as a booster to enhance the efficacy of your following skincare steps.
No, this serum has a comedogenic rating of 1/5 (very low). It's oil-free, silicone-free, and formulated with non-comedogenic ingredients. The lightweight, watery texture absorbs quickly without leaving residue. However, as with any new product, some users may experience initial purging if they have clogged pores.
The product has a 12-month Period After Opening (PAO). The airless pump packaging helps protect the formula from oxidation and contamination. Store in a cool, dry place away from direct sunlight. If you notice any changes in color, smell, or texture, discontinue use.
The sulfurous or "egg-like" smell is natural and comes from the high concentration of glutathione, which is a sulfur-containing compound. This is actually a sign of product potency. The scent dissipates quickly after application and does not linger on the skin once absorbed. Many users report getting used to it quickly.
Verdict: PURCELL L-Glutathione Flexible Liposome is an impressive K-beauty brightening serum featuring one of the highest glutathione concentrations on the market (5%) with advanced liposome delivery technology. The combination of glutathione, niacinamide, and tranexamic acid creates a powerful yet gentle brightening trio. While the sulfurous scent may take some getting used to, users consistently praise its fast-absorbing texture and visible brightening results within weeks. Best for those seeking a clinical-strength brightening treatment without hydroquinone. The main drawbacks are the small bottle size and the fact that results vary significantly between individuals - glutathione works better for some people than others. A solid choice for anyone serious about targeting hyperpigmentation and achieving a more radiant complexion.
Product Overview
What are Quick Product Notes?
Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.
Pro Tip Alert!
Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.
Quick Product Notes
Paraben-Free
Paraben-Free
Understanding Parabens
Parabens are a large group of preservatives which are used to prevent bacteria growing in cosmetic formulations. There has been some healthy controversy surrounding them due to a few studies finding paraben presence in breast tumours and breast tissue. However, the majority of the scientific community have deemed these findings non-conclusive due to the limitations of these studies. There's still a lot of support for avoiding parabens following the better safe than sorry route. If you do we completely support you! If you are concerned about the health safety of parabens, then feel free to avoid them by looking out for the Paraben-Free icon. If not, don't worry about it - they do have had one of the longest safety records as preservatives!
Which Ingredients are classified as Paraben?
A product will be paraben-free if it does not contain any of the following parabens:
- Sodium Isobutylparaben
- Sodium Ethylparaben
- Sodium Butylparaben
- Propylparaben
- Isopropylparaben
- Isobutylparaben
- Sodium Propylparaben
- Butylparaben
- Ethylparaben
- Sodium Methylparaben
- Methylparaben
Sulfate-Free
Sulfate-Free
Understanding Sulfates
Sulfates are a large group of ingredients which act as cleansing agents in Cosmetics. They help loosen up the dirt and grime from your skin and hair to allow for water to wash it away with ease. However some sulfates are so good at their job, they can wash off your skinโs own natural oils that keep it moisturised and protected which can lead to dryness and irritation. Most people will find no issues with sulfate, however if you find your skin doesn't like sulfates then free feel to avoid them by looking out for the sulfate-free icon on Skincarisma.
Which ingredients are classified as sulfates?
We've taken the Sulfates which are considered more harsh for our Sulfate-Free status. A product will be Sulfate-Free if it does not contain any of the following Sulfates:
- TEA-Dodecylbenzenesulfonate
- Ammonium Laureth Sulfate
- Sodium Lauryl Sulfate
- PEG-15 Cocamine
- Sodium Laureth Sulfate
- Sodium Cocoyl Sarcosinate
- Sodium C14-16 Olefin Sulfonate
- Dioctyl Sodium Sulfosuccinate
- Ammonium Xylenesulfonate
- Ammonium Lauryl Sulfate
- Sodium Xylenesulfonate
- Sodium Myreth Sulfate
- Sodium Lauryl Sulfoacetate
Alcohol-Free
Alcohol-Free
Understanding Simple Alcohols
Alcohol ingredients are widely used in cosmetics and come in different types. For the most part alcohols are not problematic at all. However one type of alcohols, simple alcohols can be quite drying to the skin because it evaporates very quickly. This can cause irritation which can also lead to other skin complications. These alcohols should never be used alone on your skin, but combined with other cosmetic ingredients, they are normally without issue. However, for some people with sensitive and easily irritable skin, avoiding products with these simple alcohols may be beneficial. If you find your skin doesn't like these simple alcohols, then free feel to avoid them by looking out for the Alcohol-Free icon.
Which Ingredients are classified as Alcohol?
A product will be alcohol-free if it does not contain any of the following alcohol ingredients:
- SD Alcohol
- Alcohol Denat
- Isopropyl Alcohol
- Alcohol
Silicone-Free
Silicone-Free
Understanding Silicones
If you've ever used a skincare, makeup or beauty product that's made your skin look and feel smoother tempoarily - it's likely contained Silicone. They are a popular class of ingredients found in cosmetics due to their smooth, soft, easy-to-spread and smooth properties that help creates an artificial layer/barrier on top of skin or hair (commonly found in conditioners).
For the same reasons they are popularly used, they are also commonly avoided. Anecdotally, many individuals have reported that Silicones cause/excerbate breakouts, irritation, cause a feeling of skin being unable to breathe, cause clumping of cosmetic products and find it difficult to wash off. As a result, those who find them problematic are avoiding them and increasingly, cosmetic companies are avoiding them as well.
If you have had bad experiences with Silicones in the past, or suspect they are problematic then look out for the tick on the Silicone-free label.
Disclaimer
The Silicone-free label only includes the most common Silicone ingredients that have indentified been reported by individuals that could potentially cause issues.
These include: Amodimethicone, Behenoxy Dimethicone, Bis-Aminopropyl Dimethicone, Cetearyl Methicone, Cetyl Dimethicone, Cyclomethicone, Cyclopentasiloxane, Dimethicone, Dimethicone Copolyol, Dimethiconol, Methicone, Phenyl Trimethicone, Phenyl Trimethicone, Stearoxy Dimethicone, Stearyl Dimethicone, Trimethylsilylamodimethicone.
Note, that this does not include all ingredients part of the Silicone class of ingredients.
EU Allergen-Free
EU Allergen-Free
Understanding the Identified Contact Allergens
The EU's Scientific Committee on Consumer Safety (SCCS) has identified and established 26 cosmetic ingredients that are likely contact allergens (potential to cause skin allergies) as demonstrated in clinical or epidemiological studies. The EU's SCCS have recommend cosmetic companies to disclose them on the labels if used and in cases where the concentration exceeds 0.001% in leave-on products and 0.01% in rinse-off products, then they must be labelled.
Look out for the tick on the EU-Allergen free label to know your cosmetic is free from any of the 26 identified cosmetic ingredients.
For more information regarding the EU's Scientific Committee on Consumer Safety, please visit their official website.
Disclaimer
The EU Allergen Free label is for the 26 ingredients identified by the EU SCCS and products will be only flagged if a suspected ingredient is on it's ingredient list. It is possible for cosmetics to contain one of the suspect ingredients without it appearing on the ingredient list due to it not reaching the concentration threshold to disclose it and cosmetic manufacturers choice to not disclose it.
Also note, the EU Allergen Free label is not personalized for your own allergies you may have and it does not constitute as medical advice. For your specific case, always consult your medical professiona such as dermatologist, physician, pharmacist, or health care provider - please read our medical disclaimer for more information.
Fungal Acne (Molassezia) Safe
Fungal Acne (Molassezia) Safe
Understanding Fungal Acne (Pityrosporum Folliculitis/Malassezia Folliculitis)
Pityrosporum Folliculitis/Malassezia folliculitis or simply known as Fungal Acne is a persistent acne-like condition that commonly responds poorly to traditional acne-treating methods. Unlike most cases of Acne where bacteria is the culprit, Fungi is the culprit of Fungal Acne (Hence the name!). There are certain classes & groups of ingredients that have been shown to promote and feed the growth of the Fungal Acne, Fungi such as fatty acids, oils, esters, polysorbates and fermented ingredients.
For more information regarding Fungal Acne, please visit Simple Skincare Science (f.c) - #3 of our Recommend Skincare Resources for an amazing comprehensive guide!
Please Read: How to use the Fungal Acne (Malassezia) Label
At SkinCarisma, we've done our best to identify as many ingredients as possible but note the fungal-free label may not be 100% accurate due to the complexconditions and combination of ingredients that malezzeria can thrive on.
Additionally, products that may contain ingredients that have shown to feed Malassezia may not neccessarily exacerbate the condition due to concentration of ingredient used in the product, this information is simply not available on the products.
As a result, please note this is only an experimental label that can be best used to possible identify problematic products you have used in the past. It is in no way a perfect identifier nor a predictor in whether or not it will exacerbate or cause fungal acne. It will continue to be worked on as more information and research comes to light.
If you find any ingredients you believe should be included, please email us at snails@skincarisma.com.
Disclaimer
Due to the lack of substantial research into this area it is very likely there are other ingredients and class/groups of ingredients that could feed Fungal Acne which have not been indentified.
The Fungal-Safe label does not constitute as medical advice. For your specific case, always consult your medical professiona such as dermatologist, physician, pharmacist, or health care provider - please read our medical disclaimer for more information.
What are Notable Effects & Ingredients?
Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging ยซpromisesยป it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.
We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.
Pro Tip Alert!
Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.
Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you
Notable Effects & Ingredients
Anti-Aging from 3 ingredient(s):
Brightening from 4 ingredient(s):
Promotes Wound Healing from 5 ingredient(s):
Ache-fighting from 1 ingredient(s):
What are Ingredients Related to Skin Type?
Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.
We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.
Pro Tip Alert!
A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.
One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!
Ingredients Related to Skin Types
Dry Skin
Oily/Acne-Prone Skin
Sensitive Skin
What is the Ingredient Safety Breakdown?
Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.
Pro Tip Alert!
EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.
Ingredient Safety Breakdown
Product ingredient list
| EWG | CIR | Ingredient Name & Cosmetic Functions | Notes |
|---|---|---|---|
| 1 |
Water
Solvent, Skin Conditioning
|
|
|
| 1 |
Butylene Glycol
Solvent, Skin Conditioning, Masking, Fragrance, Humectant, Viscosity Controlling, Viscositydecreasing Agent
|
Hydrating
|
|
| 2 |
Glycerin
Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant, Skin Conditioning
|
Brightening
Promotes Wound Healing
Hydrating
|
|
| 1 |
Glutathione
Fragrance, Reducing
|
Brightening
Dark Spots
|
|
| 1 |
1,2-Hexanediol
Solvent, Skin Conditioning
|
Hydrating
|