One Day Zero Exosome Shot
One Day Zero Exosome Shot
Product Description
Product overview
A viral K-beauty liquid microneedling ampoule featuring 7,500 PPM exosome-coated spicules (Hydrolyzed Sponge), Medicube's patented Lacto Exosome complex, and a triple acid blend (AHA + BHA + PHA). Inspired by professional microneedling, the micro-sized needle-shaped spicules physically deliver active ingredients deep into pores for daily at-home treatment — clinically validated to reduce pore visibility by 21.1% and boost absorption of subsequent skincare by 242%.
At-Home Liquid Microneedling
Micro-sized, needle-shaped spicules derived from marine sponge physically penetrate the epidermal layer, mimicking professional microneedling to deliver actives directly into pores for intensive daily care.
Texture & feel
SENSORYAt-Home Liquid Microneedling
Micro-sized, needle-shaped spicules derived from marine sponge physically penetrate the epidermal layer, mimicking professional microneedling to deliver actives directly into pores for intensive daily care.
+242% Absorption Boost
Clinically tested to enhance the uptake of active ingredients from subsequently applied skincare products by 242% compared to using them without the Exosome Shot.
Patented Lacto Exosome Complex
Medicube's proprietary exosome derived from Lactobacillus bacteria is packed with peptides, amino acids, glutathione, and vitamins to restore vitality, reinforce the skin barrier, and support natural skin health.
Triple Acid Exfoliation (AHA + BHA + PHA)
Betaine Salicylate (BHA), Citric Acid (AHA), and Gluconolactone (PHA) work together to dissolve dead skin cells, resurface textured skin, and minimize the appearance of enlarged pores — all without harsh irritation.
Niacinamide + Panthenol Barrier Support
A supporting duo of Niacinamide (brightening, barrier-strengthening) and Panthenol (soothing, moisture-binding) counterbalances the exfoliating actives and keeps skin balanced and hydrated.
Dermatologist & Lab Validated
Tested by the Global Institute of Dermatological Science. Non-comedogenic, low-irritation, gluten-free, and free from artificial colors. 100% of participants in a consumer study reported satisfaction equivalent to professional clinic care.
Safety & compatibility
SAFEContains Betaine Salicylate, a BHA derivative chemically related to salicylic acid. While typically found at low concentrations, it is advised to consult your healthcare provider before use during pregnancy or breastfeeding. No retinoids, hydroquinone, or high-dose chemical exfoliants are present.
Contains Ethylhexyl Palmitate, a fatty acid ester (palmitic acid C16) known to feed Malassezia yeast. This product is NOT recommended for those managing active fungal acne (pityrosporum folliculitis). Consider a spicule serum without fatty acid esters as an alternative.
Classified as non-comedogenic by the brand and confirmed by lab testing. Ethylhexyl Palmitate has a rating of ~2/5 but is present in a supporting role; the overall formula is unlikely to clog pores. Suitable for acne-prone skin.
The spicule technology causes intentional tingling, redness, and mild heat on application — a normal reaction as actives penetrate the skin. First-time users should always patch test on the inner wrist. Start 2–3 nights per week before building frequency.
Both products can be used in the same routine but not on the same night. Use the Exosome Shot 2–3x per week on alternating nights with retinol to avoid over-exfoliation, barrier disruption, or excessive irritation.
The formula already contains a full AHA + BHA + PHA acid blend. Do not apply additional exfoliating acids (like The Ordinary AHA 30%, toner pads, or BHA serums) on the same evening to prevent over-exfoliation and skin barrier damage.
Generally compatible when used on separate steps or separate evenings. If applying both in a PM routine, apply Vitamin C first and allow full absorption before the Exosome Shot, or alternate nights for a less reactive approach.
The formula already contains Niacinamide, making it seamlessly compatible with other niacinamide-containing products. No risk of "niacinamide flushing" myth — this is a non-issue in modern formulations.
Ingredient breakdown
INGREDIENTSLactobacillus Extracellular Vesicles (Lacto Exosome) 7,500 PPM (Strong)Patented
Medicube's proprietary exosome derived from Lactobacillus bacteria. Exosomes are nano-sized extracellular vesicles that act as biological messengers, delivering a payload of peptides, amino acids, glutathione, and vitamins directly into the skin. They are thought to support cellular communication, skin repair, and resilience.
- Mechanism: Nano-vesicles carry bioactive cargo including growth-factor-like peptides and antioxidants across the skin barrier
- Barrier effect: Clinical data shows +54.2% skin barrier enhancement after consistent use
- Pigmentation: Reported -7.4% melanin pigmentation improvement in brand test reports
- Radiance: +51.7% enhancement of radiance reported in self-assessment study
Hydrolyzed Sponge (Exosome-Coated Spicule) 2,000–25,000 PPMProven
Microscopic needle-shaped structures derived from marine sea sponge (Spongilla lacustris). These naturally occurring silica spicules are 200–300 µm in length and physically micro-puncture the outer epidermis, creating micro-channels for enhanced delivery of active ingredients — earning the product its "liquid microneedling" reputation.
- Penetration depth: Penetrates the epidermal layer to deliver actives beyond the stratum corneum
- Pore care: -21.1% decrease in pore visibility; -15.3% reduction in pore area; -16.7% reduction in pore volume
- Dead skin cells: +88.7% improvement in dead skin cell accumulation
- Absorption uplift: Boosts absorption of subsequent products by +242%
Niacinamide (Vitamin B3) ~2–5%Proven
One of the most well-researched skincare ingredients. Niacinamide helps regulate sebum production, minimizes pore appearance, brightens uneven skin tone, inhibits melanin transfer, strengthens the skin's moisture barrier, and has anti-inflammatory properties — making it ideal alongside the exfoliating and penetrating actives in this formula.
- Barrier function: Increases ceramide and fatty acid synthesis in the stratum corneum
- Pore size: Multiple peer-reviewed studies show reduction in pore appearance with regular use
- Brightening: Inhibits melanosome transfer from melanocytes to keratinocytes
Panthenol (Provitamin B5) ~1%Proven
A humectant and skin-conditioning agent that converts to Pantothenic Acid (Vitamin B5) in the skin. It binds and retains moisture, supports wound healing, reduces transepidermal water loss (TEWL), and soothes mild irritation — serving as a calming counterpart to the active exfoliating and penetrating ingredients in this formula.
- Hydration: Proven humectant; helps maintain optimal moisture levels after exfoliation
- Wound healing: Supports epidermal regeneration following micro-channel formation by spicules
- Tolerance: Well-tolerated even by sensitive skin types
Betaine Salicylate (BHA) + Citric Acid (AHA) + Gluconolactone (PHA) Low-ModerateProven
A triple chemical exfoliant system. Betaine Salicylate is a gentler BHA that loosens debris within pores; Citric Acid (AHA) resurfaces the skin surface and promotes cell turnover; Gluconolactone (PHA) offers the mildest exfoliation with added antioxidant and humectant properties — suitable for sensitive skin. Together they keep pores clear and texture smooth on a cellular level.
- BHA (Betaine Salicylate): Oil-soluble, penetrates into pores to dissolve sebum plugs and blackheads
- AHA (Citric Acid): Water-soluble exfoliant that breaks down the bonds between dead skin cells
- PHA (Gluconolactone): Large molecule, slow penetration, gentle exfoliation with antioxidant co-benefits
Adenosine ListedProven
A naturally occurring nucleoside that has strong anti-aging properties. Clinically shown to stimulate collagen synthesis, improve skin firmness and elasticity, and reduce the appearance of fine lines and wrinkles with consistent use. Adenosine is recognized by the Korean Ministry of Food and Drug Safety as a functional anti-wrinkle ingredient.
- Collagen synthesis: Activates fibroblast activity to promote natural collagen production
- Line volume care: Brand data reports +10.4% line volume improvement
- Regulatory status: Listed as a functional anti-wrinkle active by KFDA
27 ingredients
Water, Dipropylene Glycol, Glycerin, Butylene Glycol, 1,2-Hexanediol, Niacinamide, Sodium Polyacrylate, Ethylhexyl Palmitate, Hydrolyzed Sponge, C12-14 Alketh-12, Hydrogenated Polydecene, Ethylhexylglycerin, Adenosine, Caprylyl/Capryl Glucoside, Disodium EDTA, Panthenol, Calcium Silicate, Lactobacillus Extracellular Vesicles, Campsis Grandiflora Flower Extract, Pueraria Lobata Root Extract, Pinus Palustris Leaf Extract, Oenothera Biennis (Evening Primrose) Flower Extract, Ulmus Davidiana Root Extract, Sodium Silicate, Betaine Salicylate, Citric Acid, Gluconolactone
Where it fits in your routine
ROUTINEBest used as thefirst active step after cleansing (or after a hydrating toner for sensitive skin). The spicules work most effectively on freshly cleansed skin with open pores. Apply PM only, 2–3 nights per week for beginners; increase frequency as skin adapts. Always follow with moisturizer and apply SPF every morning.
How to use
HOW TO USECleanse Thoroughly
Wash your face with your regular cleanser and pat dry. For beginners, you may apply a hydrating toner first to act as a buffer and reduce sensitivity from the spicules.
Dispense & Apply
Shake gently, then apply 2–3 pumps to your entire face, avoiding the eye area and lips. For targeted use, apply only to areas with enlarged pores, uneven texture, or rough patches.
Rub & Press In
Gently rub and press the serum into your skin using your fingertips — do not tug or pull. The needle-shaped spicules need friction to penetrate. You will feel a tingling or warming sensation; this is normal and expected.
Wait 30–60 Seconds
Allow the formula to absorb before layering subsequent products. The spicules will continue working for several days, shedding naturally along with dead skin cells.
Follow With Moisturizer
Apply a water-based moisturizer (such as Medicube's Collagen Jelly Cream or your preferred cream) to seal in hydration and support barrier recovery. Your moisturizer will absorb up to 242% more effectively when layered after this product.
Pro Tip — AGE-R Booster Pro
For amplified results, apply the Exosome Shot immediately after using the "Air Shot Mode" of the Medicube AGE-R Booster Pro device. Not recommended for beginners or those new to spicule-based products.
Who is it for?
WHOPerfect for you if:
- You have enlarged, visible pores you want to minimize
- Your skin texture is uneven, rough, or bumpy
- You want at-home microneedling-like benefits without the clinic cost
- You struggle with blackheads or congested pores
- You want to boost the effectiveness of your existing serums and moisturizers
- You have oily or combination skin and want to control excess sebum
- You are interested in cutting-edge K-beauty technology
- Your skin is used to active ingredients like AHAs and BHAs
Consider alternatives if:
- You are pregnant or breastfeeding (consult your doctor first)
- You have active fungal acne (pityrosporum folliculitis)
- Your skin barrier is currently compromised or severely inflamed
- You have active rosacea or very reactive skin (start with 2,000 PPM or avoid)
- You are looking for a simple, one-step hydrating serum without actives
- You are new to acids and have never used BHA or AHA products before
- You plan to use it alongside retinol every night (alternate nights are fine)
Skin type compatibility
SKIN TYPESLightweight, non-greasy formula absorbs quickly without adding shine. The BHA (Betaine Salicylate) penetrates pores to dissolve excess sebum, while Niacinamide helps regulate oil production over time. Ideal for oily skin types battling enlarged pores and blackheads.
Handles well across different facial zones. The triple acid blend targets oily T-zone congestion while Panthenol and Niacinamide maintain balance in drier areas. One of the best skin types for this product.
Works beautifully for maintenance and enhancement. Normal skin tolerates the spicule technology well and will see brightening, texture refinement, and improved product absorption with regular use.
Effective but requires a richer moisturizer layered on top. The exfoliating acids may increase dryness initially; use 2x per week maximum and always follow with an occlusive or nourishing cream. May increase sensitivity in very dry skin.
Proceed with caution. The spicule technology intentionally causes a tingling and heat sensation that can be overwhelming for highly reactive skin. Start with the 2,000 PPM version, always patch test, and apply a hydrating toner as a buffer before use. Not suitable for active rosacea or compromised barriers.
Non-comedogenic and clinically tested for low irritation. The BHA content helps unclog pores and reduce blackheads. However, NOT safe for fungal acne due to Ethylhexyl Palmitate. Suitable for hormonal or bacterial acne types when the skin barrier is intact.
Results timeline
MONTH 2–3Immediate Brightness & Tingling Activation
Within minutes of application, users report a noticeable brightening effect and smooth skin surface as the spicules begin micro-channeling the skin. The characteristic tingling confirms the active delivery system is working. Some users report mild redness that subsides within 30–60 minutes.
~85% noticed immediate brightnessTexture Refinement & Pore Tightening Begins
Dead skin cell accumulation begins to improve significantly. Skin feels smoother and looks more even. Pore congestion starts to loosen. Some users notice their other skincare products feeling more effective, confirming the enhanced absorption benefit.
+88.7% dead skin cell improvement reportedVisible Pore Reduction & Radiance Boost
Measurable reduction in pore visibility and pore area. Skin radiance improves notably. Sebum regulation begins showing results for oily skin types. Skin barrier becomes noticeably stronger, reducing sensitivity to other actives.
-21.1% pore visibility reduction; +51.7% radianceComprehensive Skin Improvement
Cumulative benefits include improved skin firmness from Adenosine, brighter and more even skin tone, ongoing pore volume reduction, reduced fine line appearance, and a strengthened skin barrier. Results are most pronounced for those using 3–4 times per week consistently.
+54.2% barrier enhancement; -10.4% line volumeRatings by platform
3K+ REVIEWSPros & cons
BALANCEDPraised
- Unique liquid microneedling technology at an accessible price point
- Noticeable results from the very first use — immediate brightening
- Boosts effectiveness of all subsequent skincare products
- Fragrance-free, no artificial colors, hypoallergenic formula
- Contains multiple proven actives: Niacinamide, Adenosine, Panthenol
- Three strength levels (2,000 / 7,500 / 25,000 PPM) for all experience levels
- Clinically validated and dermatologist-tested
- Non-comedogenic — suitable for pore-prone skin
- Viral TikTok and press sensation backed by real user results
Criticized
- NOT fungal acne safe (Ethylhexyl Palmitate)
- Tingling sensation can be intense or alarming for first-time users
- Small 30ml bottle — frequent buyers needed for continuous use
- Requires cautious use during pregnancy due to BHA content
- Cannot stack with other AHA/BHA products on the same evening
- Topical exosome science is still emerging — long-term efficacy not fully established by independent research
- Not suitable for very sensitive or rosacea-prone skin without careful introduction
Budget-friendly alternatives (dupes)
DUPESUses the same spicule (reedle) technology derived from Spongilla, providing the tingling microneedling sensation. Does not contain exosomes or the triple acid blend, but is a great entry-level spicule serum. Available in strengths from 100 to 700. Widely available on YesStyle and Amazon.
Delivers the same AHA + BHA + PHA exfoliation blend at a lower cost and without spicules. Great for pore care and texture improvement through chemical exfoliation alone. No spicule delivery system or exosome technology. Fungal acne safe version available. Suitable for beginners.
An affordable chemical exfoliant peel-off treatment with high-strength AHAs and BHA. No exosomes, no spicules, and used as a rinse-off mask rather than a leave-on serum. Much stronger chemical exfoliation but lacks the penetration-boosting and delivery benefits of the Exosome Shot's spicule technology.
Comparison with competitors
SIDE-BY-SIDEDr. Jart+ Cicapair Tiger Grass Serum
Storage & shelf life
12 MONTHS12 months after opening. Use within this window for best efficacy and safety of the active ingredients, especially the exosome complex and acid blend.
Store in a cool, dry place away from direct sunlight and heat. Avoid storing in humid bathroom environments. Refrigerating the product is optional but can help extend freshness and provide a soothing effect on application.
Pump bottle (30 ml / 1.01 fl.oz). The pump dispensing system minimizes product oxidation and contamination between uses. Shake gently before use as the spicule particles may settle.
Yes — 30 ml is under the 100 ml carry-on liquid limit for most international flights. Compact pump bottle design is travel-friendly and leak-resistant.
Frequently asked questions
FAQExercise caution. The formula contains Betaine Salicylate, a BHA (beta-hydroxy acid) derivative related to salicylic acid. Salicylic acid is generally advised to be avoided during pregnancy, especially in leave-on formulas and at higher concentrations. While Betaine Salicylate is considered a gentler derivative and is present at a low concentration in this product, the current consensus among dermatologists is to err on the side of caution. No retinoids, hydroquinone, or high-dose chemical sunscreens are present. We strongly recommend consulting your OB/GYN or dermatologist before incorporating this product into your routine during pregnancy or while breastfeeding.
No — this product is NOT considered safe for fungal acne (malassezia folliculitis / pityrosporum folliculitis). The formula contains Ethylhexyl Palmitate, a C16 fatty acid ester derived from palmitic acid, which is a known feedstock for Malassezia yeast. If you are prone to fungal acne, applying this product may worsen or trigger breakouts. We recommend seeking an alternative spicule-based serum that is specifically formulated without fatty acid esters. You may want to check products like VT Cosmetics Reedle Shot or exfoliation serums verified as fungal-acne-safe on resources like HyFa (Holy Snails Fungal Acne Database).
Retinol: Do not use on the same night. Alternate evenings — for example, use the Exosome Shot Monday, Wednesday, and Friday; use retinol on Tuesday and Thursday. Using both the same night significantly increases the risk of over-exfoliation, sensitization, and barrier damage. Vitamin C: Generally compatible when applied on separate steps or separate evenings. If using both in a PM routine, apply Vitamin C first, allow it to fully absorb, then follow with the Exosome Shot. AHA/BHA/PHA: Do not stack additional exfoliating acids on the same evening — the formula already contains a triple acid blend. Applying a separate AHA toner, BHA serum, or exfoliating pad afterward would constitute over-exfoliation and may cause redness, peeling, or barrier impairment. Use the Exosome Shot on nights when you skip all other exfoliants.
This product is marketed and clinically tested for all skin types, and it performs especially well for oily, combination, and normal skin types dealing with enlarged pores, uneven texture, blackheads, or dull complexions. Those with dry skin can use it successfully but should follow up with a richer moisturizer and limit use to 2 nights per week initially. Sensitive skin types can use it with caution — starting with the 2,000 PPM version, applying a hydrating toner first as a buffer, and patch testing before full-face application. It is NOT recommended for active fungal acne, rosacea flare-ups, or compromised skin barriers.
Many users report visible brightening and smoother texture from the very first application. At the 1–2 week mark, most users notice improved skin texture and reduced congestion. By week 3–4 of consistent use (2–4 times per week), measurable pore reduction and enhanced radiance become visible — brand clinical data reports a 21.1% decrease in pore visibility and a 51.7% enhancement in radiance at this stage. Full benefits including barrier strengthening and anti-aging effects from Adenosine typically require 2–3 months of consistent use. Individual results will vary depending on skin type, the PPM version used, and how consistently the product is applied.
Apply it as the first active product after cleansing — or after a hydrating toner if your skin is sensitive. This is because the spicules work most effectively on freshly cleansed, bare skin, where they can physically micro-channel the epidermis to boost absorption. The routine order is: Cleanser → (Optional Hydrating Toner) → Exosome Shot → Serum/Essence → Moisturizer → Sunscreen (AM only). Apply only in the PM, 2–4 nights per week. Never apply immediately before sunscreen application in your AM routine — use this product at night only. Always apply SPF the following morning, as exfoliating acids increase photosensitivity.
The product is officially classified as non-comedogenic and has been validated by dermatologist testing. Its overall comedogenic rating is 1 out of 5 — considered very low. The formula is lightweight and designed specifically to target and minimize pores rather than clog them. The BHA component (Betaine Salicylate) actively works to dissolve sebum and debris within pores. However, Ethylhexyl Palmitate has a comedogenic rating of ~2/5, and individual skin reactions vary. If you have extremely pore-sensitive skin, monitor your skin closely during the first 2–3 weeks of use.
The Period After Opening (PAO) is 12 months. Once the pump is first used, the product should be consumed within one year for optimal efficacy and safety. At a typical usage of 2–4 pumps per application, 3–4 times per week, a 30 ml bottle should last approximately 6–8 weeks. Store in a cool, dry location away from direct sunlight. Shake gently before each use as spicule particles may settle between applications. Refrigeration is optional but recommended for extending freshness in warmer climates.
Verdict: The Medicube One Day Zero Exosome Shot is a genuinely innovative K-beauty product that delivers on its core promise: at-home microneedling-like benefits through an accessible, leave-on liquid ampoule. The combination of exosome-coated spicules, triple acid exfoliation (AHA + BHA + PHA), Niacinamide, Adenosine, and Panthenol makes it a multi-tasking powerhouse for pore minimization, texture refinement, and radiance enhancement. Clinical data showing a 242% boost in subsequent skincare absorption is its most compelling selling point. The biggest limitations are its unsuitability for fungal acne, the need for caution during pregnancy, and the intense tingling that can deter sensitive skin newcomers. Start at 2,000 PPM if you're new to spicules, work up to 7,500 PPM for visible results, and always follow with SPF the next morning. For anyone serious about pore care and skin texture, this product earns its viral reputation.
Product Overview
Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.
Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.
Quick Product Notes
Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging «promises» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.
We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.
Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.
Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you
Notable Effects & Ingredients
Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.
We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.
A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.
One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!
Ingredients Related to Skin Types
Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.
EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.
Ingredient Safety Breakdown
Product ingredient list
| EWG | CIR | Ingredient Name & Cosmetic Functions | Notes |
|---|---|---|---|
| 1 |
Water
Solvent, Skin Conditioning
|
|
|
| 1 |
Dipropylene Glycol
Fragrance, Solvent, Viscosity Decreasing Agent, Masking, Viscosity Controlling
|
|
|
| 2 |
Glycerin
Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant, Skin Conditioning
|
Promotes Wound Healing
Hydrating
|
|
| 1 |
Butylene Glycol
Solvent, Skin Conditioning, Masking, Fragrance, Humectant, Viscosity Controlling, Viscositydecreasing Agent
|
Hydrating
|
|
| 1 |
1,2-Hexanediol
Solvent, Skin Conditioning
|
Hydrating
|






