PDRN Collagen Cream
PDRN Collagen Cream
Product Description
Product overview
A lightweight, deeply hydrating gel-cream powered by plant-based PDRN (from rice), low-molecular collagen, and copper tripeptide-1. This triple-action formula restores elasticity, strengthens the moisture barrier, and leaves skin plump, dewy, and resilient. Clinically tested for low irritation and suitable for sensitive skin.
Plant-Based PDRN Complex
Derived from rice (Sodium DNA), this vegan PDRN supports skin regeneration, barrier repair, and overall vitality without animal-sourced ingredients.
Texture & feel
SENSORYPlant-Based PDRN Complex
Derived from rice (Sodium DNA), this vegan PDRN supports skin regeneration, barrier repair, and overall vitality without animal-sourced ingredients.
Low-Molecular Collagen
Smaller collagen fragments are more easily absorbed by skin, helping to improve elasticity and promote a firmer, smoother complexion.
Copper Tripeptide-1 (GHK-Cu)
A powerful peptide complex that stimulates healthy collagen production, supports wound healing, and provides antioxidant protection.
Triple Hydration System
Glycerin, Betaine, and Hydrolyzed Hyaluronic Acid work together to attract and lock in moisture at multiple skin layers for all-day plumpness.
Niacinamide Brightening
Vitamin B3 fades dark spots, strengthens the skin barrier, and helps regulate sebum production for a brighter, more even complexion.
Rice Ferment Filtrate
Saccharomyces/Rice Ferment Filtrate is rich in amino acids and nutrients that brighten, condition, and revitalize tired, dull skin.
Safety & compatibility
SAFENo retinoids, salicylic acid, hydroquinone, or chemical sunscreens. All ingredients are considered safe for use during pregnancy and breastfeeding.
Contains Saccharomyces/Rice Ferment Filtrate (a ferment) which may trigger fungal acne in susceptible individuals. Patch test recommended if you are prone to malassezia.
Free from oils, heavy butters, and known pore-clogging ingredients. Non-comedogenic formula suitable for acne-prone skin.
Clinically tested for low irritation at the Korea Dermatology Research Institute. No fragrance, no harsh alcohols, no common allergens.
No ingredients that conflict with retinol, vitamin C, AHAs, or BHAs. Safe to layer with actives in your routine.
Unlike most PDRN products that use salmon-derived DNA, mixsoon sources its PDRN from rice, making this a plant-based, vegan-friendly formula. Note: Collagen Extract is typically animal-derived.
Ingredient breakdown
INGREDIENTSSodium DNA (PDRN)Promising
Polydeoxyribonucleotide (PDRN) is a DNA-based active derived here from rice. It works as a skin activator — stimulating cell regeneration, supporting barrier repair, and encouraging the skin's natural healing processes.
- Mechanism: Activates adenosine A2A receptors, promoting tissue repair and anti-inflammatory responses.
- Research Note: Most clinical PDRN studies involve injectable forms; topical research is still emerging but shows good biocompatibility with human skin.
- Source: Plant-based (rice-derived), making this a vegan alternative to traditional salmon PDRN.
Collagen ExtractProven
Low-molecular weight collagen fragments that are small enough to be absorbed into the upper skin layers, helping to improve hydration, plumpness, and the appearance of fine lines.
- Function: Acts as a humectant and skin-conditioning agent, attracting moisture and improving skin texture.
- Clinical Use: Low-MW collagen has shown improvements in wrinkle appearance and elasticity in small clinical trials over 4–8 weeks.
Copper Tripeptide-1 (GHK-Cu)Proven
A naturally occurring copper-peptide complex with potent wound healing, anti-aging, and collagen-boosting properties. One of the most well-researched peptides in skincare.
- Collagen Synthesis: Stimulates production of collagen, elastin, and glycosaminoglycans for firmer skin.
- Wound Healing: Breaks down unhealthy scar tissue collagen and promotes healthy collagen production.
- Antioxidant: Significant anti-inflammatory and free-radical scavenging activity.
Niacinamide (Vitamin B3) Top 3 in INCIProven
A multifunctional skincare superstar. Fades dark spots, smooths wrinkles, strengthens the barrier, reduces redness, and helps control oil production.
- Brightening: Inhibits melanosome transfer to reduce hyperpigmentation and even skin tone.
- Barrier Support: Increases ceramide synthesis for stronger, more hydrated skin.
- Anti-Acne: Helps improve acne, rosacea, and atopic dermatitis at 4–5% concentrations.
Hydrolyzed Hyaluronic AcidProven
A low-molecular weight form of hyaluronic acid that penetrates deeper into the skin compared to regular HA, providing multi-layer hydration from within.
- Penetration: Smaller molecular size allows it to reach deeper skin layers for lasting hydration.
- Plumping: Attracts and holds up to 1,000x its weight in water, visibly plumping fine lines.
Saccharomyces/Rice Ferment FiltratePromising
A fermented rice extract rich in amino acids, vitamins, and minerals. Brightens dull skin, conditions the complexion, and supports the skin's natural microbiome.
- Brightening: Rich in kojic acid and ferulic acid precursors for natural radiance enhancement.
- Nourishing: Provides essential amino acids and minerals that support skin health and resilience.
24 ingredients
Water/Aqua, Glycerin, Niacinamide, 1,2-Hexanediol, Ammonium Acryloyldimethyltaurate/VP Copolymer, Glyceryl Acrylate/Acrylic Acid Copolymer, Betaine, Sodium Polyacryloyldimethyl Taurate, Melia Azadirachta Leaf Extract, Ethylhexylglycerin, Melia Azadirachta Flower Extract, Adenosine, Curcuma Longa (Turmeric) Root Extract, Sodium Phytate, Ocimum Sanctum Leaf Extract, Cyanocobalamin, Corallina Officinalis Extract, Hydrolyzed Hyaluronic Acid, Saccharomyces/Rice Ferment Filtrate, Pentylene Glycol, Butylene Glycol, Sodium DNA, Collagen Extract, Copper Tripeptide-1.
Where it fits in your routine
ROUTINEUse as the final moisturizing step in your routine, morning and evening. The lightweight gel-cream texture layers well under sunscreen without pilling.
How to use
HOW TO USECleanse & Tone
Start with a clean face. After cleansing, apply your toner and any treatment serums as usual.
Scoop & Apply
Take a small amount (about a pea-sized dollop) and dot it across your forehead, cheeks, nose, and chin.
Pat & Press
Gently pat and press the cream into your skin using your fingertips. Avoid rubbing — patting helps the gel-cream absorb faster and more evenly.
Layer if Needed
For extra hydration, apply a second thin layer on dry areas. In the morning, follow with sunscreen. At night, this can be your final step.
Who is it for?
WHOPerfect for you if:
- You want lightweight hydration that doesn't feel greasy or heavy
- Your skin is dry, dehydrated, or has a weakened moisture barrier
- You're looking for early anti-aging with peptides and collagen support
- You prefer a clean, minimal ingredient list (only 24 ingredients)
- You want a vegan PDRN product without salmon-derived DNA
- You need a moisturizer safe for sensitive or irritation-prone skin
- You want a dewy, glass-skin finish
Consider alternatives if:
- You have very oily skin and prefer a fully matte finish
- You need heavy-duty occlusive moisture for extremely dry or cracked skin
- You are prone to fungal acne and react to fermented ingredients
- You want clinically proven retinol-level anti-aging results
- You prefer a richer, thicker cream texture
Skin type compatibility
SKIN TYPESDeeply hydrating formula with glycerin, betaine, and hyaluronic acid replenishes dry skin. Layer for extra moisture in winter.
Lightweight gel-cream absorbs quickly without leaving a greasy residue. The dewy finish may be too much for very oily skin — use a thin layer.
Balances well across different face zones. Hydrates dry areas without overloading the T-zone. Perfect gel-cream weight.
Clinically tested for low irritation. Fragrance-free with soothing neem, turmeric, and holy basil extracts. Ideal for reactive skin.
Non-comedogenic (1/5) and oil-free. Niacinamide helps with acne. However, the ferment ingredient may not suit fungal acne-prone skin.
PDRN, collagen, and copper peptide support firmness and elasticity. For deep wrinkles, pair with retinol at night for enhanced results.
Results timeline
WEEK 6–8Immediate Hydration Boost
Skin feels noticeably more hydrated, plump, and dewy right after application. The gel-cream texture delivers an instant moisture layer.
90% noticed immediate hydrationImproved Skin Texture
Skin starts to feel smoother and softer. Niacinamide begins to refine texture and reduce the appearance of pores. Less tightness and dryness throughout the day.
75% noticed smoother textureBarrier Strengthening & Firmness
The PDRN and peptide complex support barrier repair and early firming effects. Skin appears more resilient, with a more even, brighter tone.
65% noticed improved firmnessVisible Anti-Aging Benefits
With consistent use, fine lines appear softened, elasticity improves, and the complexion looks healthier overall. Copper peptide and collagen effects become more apparent.
55% noticed reduced fine linesRatings by platform
9+ REVIEWSPros & cons
BALANCEDPraised
- Lightweight gel-cream texture absorbs quickly without stickiness
- Vegan PDRN from rice — unique in a market dominated by salmon-derived PDRN
- Clean, minimal 24-ingredient formula without fragrance, parabens, or silicones
- Clinically tested for low irritation — great for sensitive skin
- Delivers a natural dewy, glass-skin finish
- Contains proven actives: niacinamide, copper peptide, adenosine
- Layers well under makeup and sunscreen without pilling
- Affordable for K-beauty with premium peptide ingredients ($25 for 50ml)
Criticized
- 50ml size feels small — runs out quickly with twice-daily use
- Contains a ferment ingredient that may trigger fungal acne
- Topical PDRN research is still emerging — not yet on par with retinol evidence
- May not provide enough moisture for very dry or mature skin in winter
- Jar packaging (not airless pump) can expose product to air and bacteria
- Collagen Extract is typically animal-derived despite the vegan PDRN claim
Budget-friendly alternatives (dupes)
DUPESSimilar lightweight gel-cream texture with barrier-supporting and hydrating benefits. Uses snail mucin instead of PDRN for skin repair. Larger 100ml size at a lower price. No peptides or collagen.
Lightweight, soothing cream focused on barrier repair with centella asiatica. No PDRN or collagen, but excellent for sensitive skin. A gentler alternative if you react to ferments.
Multi-weight hyaluronic acid hydration in a lightweight cream. Similar dewy finish and sensitive-skin-friendly formula. No PDRN, collagen, or peptides. Great pure hydration option.
Comparison with competitors
SIDE-BY-SIDEnumbuzin No.2 Rose PDRN Collagen Plumping Serum
Storage & shelf life
12 MONTHS12 months after opening
Store in a cool, dry place away from direct sunlight. Refrigeration is not required but can enhance the cooling gel-cream experience.
Jar with screw-top lid. Use a clean spatula to maintain hygiene and prevent contamination.
Yes — 50ml is under the 100ml TSA carry-on limit for flights.
Frequently asked questions
FAQYes. This cream does not contain retinoids, salicylic acid, hydroquinone, chemical sunscreens, or any other ingredients commonly flagged as unsafe during pregnancy or breastfeeding. All ingredients are considered low-risk. As always, consult your healthcare provider if you have specific concerns.
Use with caution. The formula contains Saccharomyces/Rice Ferment Filtrate, which is a fermented ingredient that may feed malassezia yeast in some individuals. If you are prone to fungal acne, patch test on a small area first and monitor for breakouts over 1–2 weeks before full-face use.
Yes. This cream is formulated without any ingredients that conflict with common actives. You can safely layer it over retinol, vitamin C serums, AHAs (glycolic, lactic acid), and BHAs (salicylic acid). In fact, the niacinamide and soothing extracts can help calm irritation from these actives. Apply your actives first, wait a minute, then follow with this cream.
This cream is excellent for dry, dehydrated, combination, and sensitive skin types. Its lightweight gel-cream texture also works well for oily skin when applied in a thin layer. It is especially suited for those seeking hydration, barrier repair, and early anti-aging benefits. Mature skin can benefit from the peptide and collagen complex, though pairing it with a richer night cream may be advisable in colder months.
Hydration and plumpness are noticeable from the first application. Improved skin texture typically appears within 1–2 weeks. For firming, barrier repair, and anti-aging benefits from the PDRN, collagen, and copper peptide complex, expect to see gradual improvements over 4–8 weeks of consistent daily use, morning and evening.
Use it as your moisturizer — the final step before sunscreen (AM) or as the last step (PM). Apply after cleansing, toner, and any treatment serums or essences. Its gel-cream texture seals in previous layers of hydration without feeling heavy. The brand recommends using it morning and evening.
This cream has a comedogenic rating of 1 out of 5, meaning it has a very low risk of clogging pores. The formula is free from oils, silicones, and common pore-clogging ingredients. It is described as non-comedogenic by the brand and is suitable for acne-prone skin. However, individual skin responses can vary, so patch testing is always recommended.
The Period After Opening (PAO) is 12 months. Once opened, use the product within one year for optimal freshness and efficacy. Store in a cool, dry place away from direct sunlight. Since it comes in a jar, use a clean spatula or scoop to minimize bacterial contamination and extend product life.
Verdict: The mixsoon PDRN Collagen Cream is an excellent lightweight moisturizer for anyone seeking hydration, barrier repair, and gentle anti-aging in a clean formula. Its standout feature is the vegan, rice-derived PDRN — a refreshing alternative in a market dominated by salmon DNA products. Combined with proven actives like niacinamide, copper tripeptide-1, and hydrolyzed hyaluronic acid in a minimal 24-ingredient formula, it delivers real results without unnecessary irritants. The main limitations are its small 50ml size, the ferment that may not suit fungal acne-prone skin, and the fact that topical PDRN research is still maturing. For the price point ($25), it offers strong value as a daily moisturizer with modern K-beauty innovation.
Product Overview
Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.
Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.
Quick Product Notes
Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging «promises» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.
We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.
Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.
Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you
Notable Effects & Ingredients
Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.
We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.
A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.
One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!
Ingredients Related to Skin Types
Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.
EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.
Ingredient Safety Breakdown
Product ingredient list
| EWG | CIR | Ingredient Name & Cosmetic Functions | Notes |
|---|---|---|---|
| 1 |
Water
Solvent, Skin Conditioning
|
|
|
| 2 |
Glycerin
Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant, Skin Conditioning
|
Promotes Wound Healing
Hydrating
|
|
| 1 |
Niacinamide
Skin Conditioning, Hair Conditioning, Smoothing
|
Promotes Wound Healing
Redness
Irritation
Dark Spots
Pores
|
|
| 1 |
1,2-Hexanediol
Solvent, Skin Conditioning
|
Hydrating
|
|
| 1 |
Ammonium Acryloyldimethyltaurate/VP Copolymer
Viscosity Controlling
|
|







