Advanced PDRN Repair Cream
Advanced PDRN Repair Cream
Product Description
Product overview
A lightweight, fast-absorbing gel-cream featuring 1,200ppm of 99% pure Salmon PDRN (Polydeoxyribonucleotide) combined with Niacinamide, Panthenol, and Hydrolyzed Collagen. Developed by doctors and pharmacists, this pharmacy-exclusive K-beauty cream supports skin regeneration, barrier repair, and overnight recovery for visibly smoother, firmer, and more radiant skin.
Optimal PDRN Concentration
Contains 1,200ppm PDRN - clinically supported as the optimal range for skin regeneration without diminishing returns.
Texture & feel
SENSORYOptimal PDRN Concentration
Contains 1,200ppm PDRN - clinically supported as the optimal range for skin regeneration without diminishing returns.
Developed by Experts
Created by doctors and pharmacists. Trusted by 5,000+ Korean pharmacies and beauty clinics.
99% Pure Salmon DNA
Advanced purification methods ensure high purity PDRN with uniform micro-sized particles for smooth absorption.
Dermatest Certified
Rated "Excellent" by Germany Dermatest for skin compatibility with a 0.00 irritation index.
Safety & compatibility
SAFELimited research on topical PDRN during pregnancy. No known harmful ingredients (retinoids, salicylic acid), but consult your doctor before use.
Contains silicones, polysorbates, and fatty acid esters that may feed malassezia. Not recommended for fungal acne-prone skin.
Dermatologically tested with 0.00 irritation index. Gentle enough for the delicate eye area.
Excellent for recovery after microneedling, laser treatments, and chemical peels. Supports wound healing.
PDRN is derived from salmon DNA. Those with severe fish or seafood allergies should avoid this product or patch test first.
Will not clog pores. Dermatest certified as non-comedogenic with rating of 1/5.
Ingredient breakdown
INGREDIENTSPDRN (Sodium DNA) 1,200ppmProven
Polydeoxyribonucleotide derived from 99% pure salmon DNA. Activates A2A adenosine receptors to reduce inflammation and support tissue regeneration at a cellular level.
- Mechanism: Provides nucleotides and nucleosides that serve as building blocks for DNA synthesis and cell regeneration
- Research: Extensively studied in injectable form for wound healing and skin rejuvenation since the 1990s
- Concentration: 1,200ppm is clinically supported as optimal - higher concentrations show no additional benefits
Niacinamide (Vitamin B3) 2%Proven
A multi-tasking powerhouse that strengthens the skin barrier, reduces pores and dark spots, regulates oil production, and improves signs of aging.
- Brightening: Inhibits melanosome transfer to reduce hyperpigmentation and even skin tone
- Barrier Support: Increases ceramide production to strengthen the skin's moisture barrier
- Anti-Aging: Boosts NAD+ levels to support cellular repair and collagen production
Hydrolyzed Collagen 20,000ppmPromising
Low molecular weight (300 Dalton) collagen peptides that provide surface hydration and temporary plumping effect. Helps improve skin texture and firmness.
- Hydration: Acts as a humectant to attract and retain moisture in the skin
- Texture: Creates a smooth, bouncy feel on the skin surface
- Note: Cannot replace natural collagen at deeper levels but supports surface hydration
Panthenol (Pro-Vitamin B5) 1%Proven
A gentle, effective moisturizer that soothes irritation, supports wound healing, and helps maintain the skin's protective barrier.
- Barrier Repair: Converted to pantothenic acid in skin to support barrier function
- Soothing: Calms redness and irritation, making it ideal for sensitive skin
- Comedogenicity: Rating of 0 - will not clog pores
Sodium Hyaluronate IncludedProven
The salt form of hyaluronic acid that can bind up to 1,000 times its weight in water, providing deep hydration and plumping effects.
- Hydration: Attracts and holds water molecules to keep skin hydrated
- Penetration: Smaller molecular size allows better absorption than hyaluronic acid
31 ingredients
Water, Glycerin, Butylene Glycol, Cyclopentasiloxane, Dimethicone, 1,2-Hexanediol, Niacinamide, Hydrolyzed Collagen, Cyclohexasiloxane, Sodium Hyaluronate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Cetearyl Olivate, Arginine, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Sorbitan Olivate, Polyacrylamide, C13-14 Isoalkane, Dimethiconol, Sodium DNA (PDRN 1,200ppm), Cellulose Gum, Allantoin, Laureth-7, Fragrance, Adenosine, Sorbitan Isostearate, Melia Azadirachta Leaf Extract, Melia Azadirachta Flower Extract, Panthenol, Betaine, Coccinia Indica Fruit Extract, Corallina Officinalis Extract
Where it fits in your routine
ROUTINEUse as final step at night or before moisturizer. Can replace moisturizer for oily skin types. Allow full absorption before layering.
How to use
HOW TO USECleanse & Prep
After cleansing and applying toner/essence, ensure skin is slightly damp for better absorption.
Apply to Face
Take a small amount (pea-sized) and gently massage over face and neck in upward motions until fully absorbed.
Target Areas
Can be applied to delicate eye area and targeted on areas needing extra repair like acne scars or post-procedure skin.
Daily Use
Use morning and evening for best results. For daytime, allow full absorption before applying sunscreen or makeup.
Who is it for?
WHOPerfect for you if:
- You want to support skin regeneration and repair
- You're recovering from microneedling, lasers, or chemical peels
- You have dull, tired-looking skin that needs revitalization
- You want lightweight hydration without heaviness
- You have oily, combination, or normal skin
- You want to improve skin texture and firmness
- You prefer gel-cream textures that absorb quickly
Consider alternatives if:
- You have fungal acne (malassezia folliculitis)
- You have severe fish or seafood allergies
- You need very heavy, occlusive moisture (dry skin)
- You're pregnant/breastfeeding and want to avoid caution ingredients
- You prefer fragrance-free products (light scent present)
- You want a larger size (only comes in 20g)
Skin type compatibility
SKIN TYPESLightweight gel texture absorbs quickly without adding shine. Can be used as a standalone moisturizer.
Balances well across different face zones. Hydrates dry areas without overwhelming oily T-zone.
Perfect daily cream for maintaining healthy, balanced skin with regenerative benefits.
Provides hydration but may need a heavier moisturizer layered on top for very dry skin.
Dermatest certified with 0.00 irritation index. Light fragrance present - patch test if very reactive.
Non-comedogenic but not fungal acne safe. Good for traditional acne healing, avoid if you have malassezia.
Results timeline
WEEK 8+Immediate Hydration & Comfort
Skin feels instantly hydrated and comfortable. Post-shower tightness disappears. No new breakouts or irritation.
90% noticed improved hydrationSmoother Texture
Visible improvement in skin smoothness. Refined pores and silky texture that makes you want to keep touching your face.
75% noticed smoother skinVisible Glow & Brightness
Noticeable improvement in skin radiance and brightness. Can skip vitamin C on lazy mornings without looking sallow.
70% noticed improved glowFirmness & Recovery
Improved skin elasticity and firmness. Enhanced healing of minor scars and blemishes. Overall healthier-looking skin.
65% noticed firmer skinRatings by platform
700+ REVIEWSPros & cons
BALANCEDPraised
- Lightweight gel texture absorbs beautifully
- Excellent post-procedure recovery support
- Highest PDRN concentration (1,200ppm) among competitors
- Non-comedogenic with 0.00 irritation index
- Noticeable hydration and glow within 1-2 weeks
- Developed by doctors and pharmacists
- Great for oily and combination skin
- Can be used morning and night
Criticized
- Small size (20g) for premium price
- Not fungal acne safe
- Contains fragrance (light but present)
- Topical PDRN won't match injectable results
- May not be enough for very dry skin
- Contains silicones (some prefer silicone-free)
- Not suitable for fish allergy sufferers
- Pregnancy safety not fully established
Budget-friendly alternatives (dupes)
DUPESSimilar PDRN + HA formula in a larger 60ml size. Fragrance-free option. Lower PDRN concentration but better value per ml.
100,000ppm vegan PDRN from ginseng (not salmon). Visible capsules, 5-ceramide complex. Great for those avoiding fish-derived ingredients.
Unique dual-texture with pink capsules. Customizable ratio. More focus on collagen and peptides. Popular TikTok viral option.
Original pharmacy PDRN cream with 800ppm. Richer, more occlusive texture. Better for very dry skin. Made by PDRN injection manufacturer.
Comparison with competitors
SIDE-BY-SIDERejuall PDRN Cream
Pharmaresearch Rejuvenex
Storage & shelf life
12 MONTHS12 months after opening
Store in a cool, dry place away from direct sunlight. Refrigeration not required but can extend freshness.
Tube packaging with screw cap. Protects formula from air and light exposure.
Yes, 20g/0.7oz is well under the 100ml TSA limit. Compact tube fits easily in travel bags.
Frequently asked questions
FAQThere is limited research on topical PDRN during pregnancy and breastfeeding. The formula does not contain known pregnancy-unsafe ingredients like retinoids, salicylic acid, or hydroquinone. However, due to the lack of comprehensive safety data on PDRN specifically, we recommend consulting with your healthcare provider before use during pregnancy or while breastfeeding.
No, this product is not fungal acne safe. It contains silicones (cyclopentasiloxane, dimethicone), polysorbates, and fatty acid esters that can feed malassezia yeast. If you're prone to fungal acne or pityrosporum folliculitis, consider alternatives like VT Cosmetics vegan PDRN products or consult the fungal acne safe product lists.
Yes, PDRN cream is generally compatible with most active ingredients. However, for optimal results: use vitamin C in the morning and PDRN at night; wait 15-20 minutes between applying strong acids (AHA/BHA) and this cream; when using retinol, apply the PDRN cream first as a buffer layer or on alternate nights if your skin is sensitive. The soothing properties of PDRN can actually help calm skin irritated by other actives.
This cream is best suited for oily, combination, and normal skin types due to its lightweight gel-cream texture. It absorbs quickly without leaving residue or greasiness. Those with dry skin can still use it but may need to layer a heavier moisturizer on top. The formula is dermatologically tested and suitable for sensitive skin, though those with very reactive skin should patch test first due to the light fragrance.
Results timeline varies by concern: immediate hydration within the first use; smoother texture and comfort within 1-2 weeks; visible glow and brightness at 4-6 weeks; improved firmness and scar healing at 8+ weeks of consistent use. For post-procedure recovery (microneedling, lasers), many users report faster healing within 1-2 weeks. Note that topical PDRN results will be more gradual than injectable treatments.
Use this cream as the final step of your skincare routine at night, or before moisturizer/sunscreen in the morning. The typical order is: Cleanser → Toner → Essence/Serum → Rejuall PDRN Cream → Heavier Moisturizer (if needed) → Sunscreen (AM only). For oily skin, this cream can be used as your only moisturizer. Always allow it to absorb fully before layering additional products.
No, this product is non-comedogenic with a rating of 1/5. It has been certified by Germany's Dermatest with a 0.00 irritation index and confirmed as non-pore-clogging. The lightweight gel-cream formula is designed to absorb quickly without leaving pore-clogging residue. However, it is not fungal acne safe due to certain emollients and emulsifiers in the formula.
The product has a PAO (Period After Opening) of 12 months. Store in a cool, dry place away from direct sunlight to maintain efficacy. The 20g tube typically lasts 6-8 weeks with twice-daily use on face and neck. While refrigeration is not required, it can help extend freshness and provide a cooling sensation upon application.
Verdict: Rejuall Advanced PDRN Repair Cream delivers on its promise as a premium K-beauty repair cream with the highest PDRN concentration (1,200ppm) among competitors. The lightweight gel-cream texture is perfect for oily to normal skin types, absorbing quickly without greasiness. While topical PDRN won't replicate injectable results, this formula excels at hydration, post-procedure recovery, and supporting overall skin health. The main drawbacks are the small 20g size for the price point and lack of fungal acne safety. Best for: Anyone seeking lightweight, science-backed regenerative skincare, especially those recovering from procedures or wanting to improve skin texture and glow.
Product Overview
Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.
Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.
Quick Product Notes
Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging «promises» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.
We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.
Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.
Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you
Notable Effects & Ingredients
Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.
We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.
A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.
One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!
Ingredients Related to Skin Types
Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.
EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.
Ingredient Safety Breakdown
Product ingredient list
| EWG | CIR | Ingredient Name & Cosmetic Functions | Notes |
|---|---|---|---|
| 1 |
Water
Solvent, Skin Conditioning
|
|
|
| 2 |
Glycerin
Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant, Skin Conditioning
|
Promotes Wound Healing
Hydrating
|
|
| 1 |
Butylene Glycol
Solvent, Skin Conditioning, Masking, Fragrance, Humectant, Viscosity Controlling, Viscositydecreasing Agent
|
Hydrating
|
|
| 3 |
Cyclopentasiloxane
Solvent, Skin Conditioning, Emollient, Hair Conditioning
|
|
|
| 3 |
Dimethicone
Skin Conditioning, Emollient, Antifoaming Agent, Skin Protecting
|
|





