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Advanced PDRN Repair Cream

Advanced PDRN Repair Cream

Product Description

Product overview

Made in Various INTERNATIONAL

A lightweight, fast-absorbing gel-cream featuring 1,200ppm of 99% pure Salmon PDRN (Polydeoxyribonucleotide) combined with Niacinamide, Panthenol, and Hydrolyzed Collagen. Developed by doctors and pharmacists, this pharmacy-exclusive K-beauty cream supports skin regeneration, barrier repair, and overnight recovery for visibly smoother, firmer, and more radiant skin.

Dermatologist Tested 0.00 Irritation Index Non-Comedogenic 99% Pure Salmon PDRN Pharmacy Exclusive 1M+ Units Sold
Pregnancy
Caution
Fungal Acne
No
Comedogenic
1/5
Size
20g / 0.7oz
PDRN
1,200ppm
Niacinamide
2%
Collagen
20,000ppm
Panthenol
1%
Real reviews · YouTube Shorts
Why it's different

Optimal PDRN Concentration

Contains 1,200ppm PDRN - clinically supported as the optimal range for skin regeneration without diminishing returns.

01

Texture & feel

SENSORY
Consistency
Lightweight Gel-Cream
Scent
Light, Fades Quickly
Absorption
Under 1 Minute
Finish
Smooth, Non-Greasy

Optimal PDRN Concentration

Contains 1,200ppm PDRN - clinically supported as the optimal range for skin regeneration without diminishing returns.

Developed by Experts

Created by doctors and pharmacists. Trusted by 5,000+ Korean pharmacies and beauty clinics.

99% Pure Salmon DNA

Advanced purification methods ensure high purity PDRN with uniform micro-sized particles for smooth absorption.

Dermatest Certified

Rated "Excellent" by Germany Dermatest for skin compatibility with a 0.00 irritation index.

02

Safety & compatibility

SAFE
Pregnancy & Breastfeeding

Limited research on topical PDRN during pregnancy. No known harmful ingredients (retinoids, salicylic acid), but consult your doctor before use.

Fungal Acne (Malassezia)

Contains silicones, polysorbates, and fatty acid esters that may feed malassezia. Not recommended for fungal acne-prone skin.

Sensitive Skin

Dermatologically tested with 0.00 irritation index. Gentle enough for the delicate eye area.

Post-Procedure Use

Excellent for recovery after microneedling, laser treatments, and chemical peels. Supports wound healing.

Fish Allergy Warning

PDRN is derived from salmon DNA. Those with severe fish or seafood allergies should avoid this product or patch test first.

Non-Comedogenic

Will not clog pores. Dermatest certified as non-comedogenic with rating of 1/5.

03

Ingredient breakdown

INGREDIENTS

PDRN (Sodium DNA) 1,200ppmProven

Polydeoxyribonucleotide derived from 99% pure salmon DNA. Activates A2A adenosine receptors to reduce inflammation and support tissue regeneration at a cellular level.

  • Mechanism: Provides nucleotides and nucleosides that serve as building blocks for DNA synthesis and cell regeneration
  • Research: Extensively studied in injectable form for wound healing and skin rejuvenation since the 1990s
  • Concentration: 1,200ppm is clinically supported as optimal - higher concentrations show no additional benefits
Note: Most PDRN research is based on injectable forms. Topical absorption is limited by large molecular size, so effects may be milder than professional treatments.

Niacinamide (Vitamin B3) 2%Proven

A multi-tasking powerhouse that strengthens the skin barrier, reduces pores and dark spots, regulates oil production, and improves signs of aging.

  • Brightening: Inhibits melanosome transfer to reduce hyperpigmentation and even skin tone
  • Barrier Support: Increases ceramide production to strengthen the skin's moisture barrier
  • Anti-Aging: Boosts NAD+ levels to support cellular repair and collagen production
Well-tolerated by most skin types including sensitive skin. No niacin flush at this concentration.

Hydrolyzed Collagen 20,000ppmPromising

Low molecular weight (300 Dalton) collagen peptides that provide surface hydration and temporary plumping effect. Helps improve skin texture and firmness.

  • Hydration: Acts as a humectant to attract and retain moisture in the skin
  • Texture: Creates a smooth, bouncy feel on the skin surface
  • Note: Cannot replace natural collagen at deeper levels but supports surface hydration

Panthenol (Pro-Vitamin B5) 1%Proven

A gentle, effective moisturizer that soothes irritation, supports wound healing, and helps maintain the skin's protective barrier.

  • Barrier Repair: Converted to pantothenic acid in skin to support barrier function
  • Soothing: Calms redness and irritation, making it ideal for sensitive skin
  • Comedogenicity: Rating of 0 - will not clog pores

Sodium Hyaluronate IncludedProven

The salt form of hyaluronic acid that can bind up to 1,000 times its weight in water, providing deep hydration and plumping effects.

  • Hydration: Attracts and holds water molecules to keep skin hydrated
  • Penetration: Smaller molecular size allows better absorption than hyaluronic acid

31 ingredients

Water, Glycerin, Butylene Glycol, Cyclopentasiloxane, Dimethicone, 1,2-Hexanediol, Niacinamide, Hydrolyzed Collagen, Cyclohexasiloxane, Sodium Hyaluronate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Cetearyl Olivate, Arginine, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Sorbitan Olivate, Polyacrylamide, C13-14 Isoalkane, Dimethiconol, Sodium DNA (PDRN 1,200ppm), Cellulose Gum, Allantoin, Laureth-7, Fragrance, Adenosine, Sorbitan Isostearate, Melia Azadirachta Leaf Extract, Melia Azadirachta Flower Extract, Panthenol, Betaine, Coccinia Indica Fruit Extract, Corallina Officinalis Extract

FREE FROM: Parabens, Sulfates, Artificial Colors, Mineral Oil, Retinoids, Hydroquinone, Chemical Sunscreens, Harsh Alcohols
04

Where it fits in your routine

ROUTINE
1
Cleanser
2
Toner
3
Essence/Serum
4
This Product
5
Moisturizer
6
Sunscreen (AM)

Use as final step at night or before moisturizer. Can replace moisturizer for oily skin types. Allow full absorption before layering.

05

How to use

HOW TO USE
1

Cleanse & Prep

After cleansing and applying toner/essence, ensure skin is slightly damp for better absorption.

2

Apply to Face

Take a small amount (pea-sized) and gently massage over face and neck in upward motions until fully absorbed.

3

Target Areas

Can be applied to delicate eye area and targeted on areas needing extra repair like acne scars or post-procedure skin.

4

Daily Use

Use morning and evening for best results. For daytime, allow full absorption before applying sunscreen or makeup.

06

Who is it for?

WHO

Perfect for you if:

  • You want to support skin regeneration and repair
  • You're recovering from microneedling, lasers, or chemical peels
  • You have dull, tired-looking skin that needs revitalization
  • You want lightweight hydration without heaviness
  • You have oily, combination, or normal skin
  • You want to improve skin texture and firmness
  • You prefer gel-cream textures that absorb quickly

Consider alternatives if:

  • You have fungal acne (malassezia folliculitis)
  • You have severe fish or seafood allergies
  • You need very heavy, occlusive moisture (dry skin)
  • You're pregnant/breastfeeding and want to avoid caution ingredients
  • You prefer fragrance-free products (light scent present)
  • You want a larger size (only comes in 20g)
07

Skin type compatibility

SKIN TYPES
Oily Skin
Excellent

Lightweight gel texture absorbs quickly without adding shine. Can be used as a standalone moisturizer.

Combination Skin
Excellent

Balances well across different face zones. Hydrates dry areas without overwhelming oily T-zone.

Normal Skin
Excellent

Perfect daily cream for maintaining healthy, balanced skin with regenerative benefits.

Dry Skin
Good

Provides hydration but may need a heavier moisturizer layered on top for very dry skin.

Sensitive Skin
Good

Dermatest certified with 0.00 irritation index. Light fragrance present - patch test if very reactive.

Acne-Prone Skin
Moderate

Non-comedogenic but not fungal acne safe. Good for traditional acne healing, avoid if you have malassezia.

08

Results timeline

WEEK 8+
Week 1

Immediate Hydration & Comfort

Skin feels instantly hydrated and comfortable. Post-shower tightness disappears. No new breakouts or irritation.

90% noticed improved hydration
Week 2

Smoother Texture

Visible improvement in skin smoothness. Refined pores and silky texture that makes you want to keep touching your face.

75% noticed smoother skin
Week 4-6

Visible Glow & Brightness

Noticeable improvement in skin radiance and brightness. Can skip vitamin C on lazy mornings without looking sallow.

70% noticed improved glow
Week 8+

Firmness & Recovery

Improved skin elasticity and firmness. Enhanced healing of minor scars and blemishes. Overall healthier-looking skin.

65% noticed firmer skin
09

Ratings by platform

700+ REVIEWS
Amazon
4.7
Rating
500+
Reviews
Main complaint: Small tube size (20g) for the price point
Brand Website
4.9
Rating
1M+ Units
Sold in 6 Months
Main complaint: Often sells out at Korean pharmacies
YesStyle
4.8
Rating
200+
Reviews
Main complaint: Shipping times and authenticity concerns from third-party sellers
TikTok/Social
4.8
Sentiment
Viral
Status
Main complaint: Hype may create unrealistic expectations vs. injectable PDRN
10

Pros & cons

BALANCED

Praised

  • Lightweight gel texture absorbs beautifully
  • Excellent post-procedure recovery support
  • Highest PDRN concentration (1,200ppm) among competitors
  • Non-comedogenic with 0.00 irritation index
  • Noticeable hydration and glow within 1-2 weeks
  • Developed by doctors and pharmacists
  • Great for oily and combination skin
  • Can be used morning and night

Criticized

  • Small size (20g) for premium price
  • Not fungal acne safe
  • Contains fragrance (light but present)
  • Topical PDRN won't match injectable results
  • May not be enough for very dry skin
  • Contains silicones (some prefer silicone-free)
  • Not suitable for fish allergy sufferers
  • Pregnancy safety not fully established
11

Budget-friendly alternatives (dupes)

DUPES
85% Match
PDRN Hyaluronic Acid 100 Moisturizing Cream
$24.00
Budget Pick

Similar PDRN + HA formula in a larger 60ml size. Fragrance-free option. Lower PDRN concentration but better value per ml.

80% Match
PDRN Essence 100
$19.00
Budget Pick

100,000ppm vegan PDRN from ginseng (not salmon). Visible capsules, 5-ceramide complex. Great for those avoiding fish-derived ingredients.

75% Match
PDRN Pink Collagen Capsule Cream
$27.00
Similar Price

Unique dual-texture with pink capsules. Customizable ratio. More focus on collagen and peptides. Popular TikTok viral option.

70% Match
Cream
$50.00

Original pharmacy PDRN cream with 800ppm. Richer, more occlusive texture. Better for very dry skin. Made by PDRN injection manufacturer.

12

Comparison with competitors

SIDE-BY-SIDE

Pharmaresearch Rejuvenex

PDRN Concentration 800ppm
Size 10g (Smaller)
Texture Rich Cream/Ointment
Best For Dry/Post-Procedure
PDRN Source Salmon DNA
PDRN Hyaluronic Acid 100 Moisturizing Cream
PDRN Concentration Not Specified
Size 60ml (3x Larger)
Texture Lightweight Cream
Best For Normal/Daily Use
PDRN Source Salmon DNA
PDRN Essence 100
PDRN Concentration 100,000ppm
Size 50ml
Texture Gel with Capsules
Best For Vegan/All Types
PDRN Source Vegan (Ginseng)
13

Storage & shelf life

12 MONTHS
Period After Opening (PAO)

12 months after opening

Storage

Store in a cool, dry place away from direct sunlight. Refrigeration not required but can extend freshness.

Packaging

Tube packaging with screw cap. Protects formula from air and light exposure.

Travel Friendly

Yes, 20g/0.7oz is well under the 100ml TSA limit. Compact tube fits easily in travel bags.

13

Frequently asked questions

FAQ

There is limited research on topical PDRN during pregnancy and breastfeeding. The formula does not contain known pregnancy-unsafe ingredients like retinoids, salicylic acid, or hydroquinone. However, due to the lack of comprehensive safety data on PDRN specifically, we recommend consulting with your healthcare provider before use during pregnancy or while breastfeeding.

No, this product is not fungal acne safe. It contains silicones (cyclopentasiloxane, dimethicone), polysorbates, and fatty acid esters that can feed malassezia yeast. If you're prone to fungal acne or pityrosporum folliculitis, consider alternatives like VT Cosmetics vegan PDRN products or consult the fungal acne safe product lists.

Yes, PDRN cream is generally compatible with most active ingredients. However, for optimal results: use vitamin C in the morning and PDRN at night; wait 15-20 minutes between applying strong acids (AHA/BHA) and this cream; when using retinol, apply the PDRN cream first as a buffer layer or on alternate nights if your skin is sensitive. The soothing properties of PDRN can actually help calm skin irritated by other actives.

This cream is best suited for oily, combination, and normal skin types due to its lightweight gel-cream texture. It absorbs quickly without leaving residue or greasiness. Those with dry skin can still use it but may need to layer a heavier moisturizer on top. The formula is dermatologically tested and suitable for sensitive skin, though those with very reactive skin should patch test first due to the light fragrance.

Results timeline varies by concern: immediate hydration within the first use; smoother texture and comfort within 1-2 weeks; visible glow and brightness at 4-6 weeks; improved firmness and scar healing at 8+ weeks of consistent use. For post-procedure recovery (microneedling, lasers), many users report faster healing within 1-2 weeks. Note that topical PDRN results will be more gradual than injectable treatments.

Use this cream as the final step of your skincare routine at night, or before moisturizer/sunscreen in the morning. The typical order is: Cleanser → Toner → Essence/Serum → Rejuall PDRN Cream → Heavier Moisturizer (if needed) → Sunscreen (AM only). For oily skin, this cream can be used as your only moisturizer. Always allow it to absorb fully before layering additional products.

No, this product is non-comedogenic with a rating of 1/5. It has been certified by Germany's Dermatest with a 0.00 irritation index and confirmed as non-pore-clogging. The lightweight gel-cream formula is designed to absorb quickly without leaving pore-clogging residue. However, it is not fungal acne safe due to certain emollients and emulsifiers in the formula.

The product has a PAO (Period After Opening) of 12 months. Store in a cool, dry place away from direct sunlight to maintain efficacy. The 20g tube typically lasts 6-8 weeks with twice-daily use on face and neck. While refrigeration is not required, it can help extend freshness and provide a cooling sensation upon application.

— Skincarisma verdict
4.5 / 5 ★★★★★

Verdict: Rejuall Advanced PDRN Repair Cream delivers on its promise as a premium K-beauty repair cream with the highest PDRN concentration (1,200ppm) among competitors. The lightweight gel-cream texture is perfect for oily to normal skin types, absorbing quickly without greasiness. While topical PDRN won't replicate injectable results, this formula excels at hydration, post-procedure recovery, and supporting overall skin health. The main drawbacks are the small 20g size for the price point and lack of fungal acne safety. Best for: Anyone seeking lightweight, science-backed regenerative skincare, especially those recovering from procedures or wanting to improve skin texture and glow.

Product Overview

question
lightbulb What are Quick Product Notes?

Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.

muscle Pro Tip Alert!

Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.

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Quick Product Notes

Click on icons for more information
question
lightbulb What are Notable Effects & Ingredients?

Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging «promises» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.

We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.

muscle Pro Tip Alert!

Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.

Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you

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Notable Effects & Ingredients

anti-aging Anti-Aging from 4 ingredient(s):
Niacinamide Hydrolyzed Collagen Sodium DNA Adenosine
brightening Brightening from 2 ingredient(s):
Glycerin Niacinamide
wound Promotes Wound Healing from 7 ingredient(s):
Glycerin Niacinamide Sodium Hyaluronate Arginine Allantoin Adenosine Panthenol
ache Ache-fighting from 1 ingredient(s):
Niacinamide
question
lightbulb What are Ingredients Related to Skin Type?

Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.

We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.

muscle Pro Tip Alert!

A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.

One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!

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Ingredients Related to Skin Types

Click on icons for more information
dry-skin Dry Skin
4
oily-skin Oily/Acne-Prone Skin
2
sensitive-skin Sensitive Skin
1
question
lightbulb What is the Ingredient Safety Breakdown?

Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.

muscle Pro Tip Alert!

EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.

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Ingredient Safety Breakdown

EWG Health Ratings
Low risk
Medium risk
High risk
Unknown risk
70% 9% 19%

Product ingredient list

Showing first 5 of 31 ingredients
EWG CIR Ingredient Name & Cosmetic Functions Notes
1 Unknown
Water
Solvent, Skin Conditioning
2 A
Glycerin
Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant, Skin Conditioning
brightening Brightening
Promotes Wound Healing
Hydrating
1 A
Butylene Glycol
Solvent, Skin Conditioning, Masking, Fragrance, Humectant, Viscosity Controlling, Viscositydecreasing Agent
Hydrating
3 A
Cyclopentasiloxane
Solvent, Skin Conditioning, Emollient, Hair Conditioning
3 A
Dimethicone
Skin Conditioning, Emollient, Antifoaming Agent, Skin Protecting
VIEW ALL INGREDIENTS