Skip to content

Multi-Action Cream

Multi-Action Cream

Product Description

Product overview

Made in Various INTERNATIONAL

A corrective treatment cream powered by patented PTT-6® stem cell technology. Derived from red deer umbilical cord lining extract, this intensive formula delivers over 3,000 growth factors and exosomes to actively lift, firm, and rebuild skin structure. Visible improvements in as little as 2 weeks, with optimal results at 90 days.

Fragrance-Free Dermatologist-Tested Patented PTT-6® Technology Post-Procedure Safe Cruelty-Free Pregnancy Safe ISO-Certified Lab
Pregnancy
Yes
Fungal Acne
No
Comedogenic
3/5
Size
50g / 1.76 oz
Price
$200.00
Type
Treatment Cream
Target
Anti-Aging
Use
AM & PM
Real reviews · YouTube Shorts
Why it's different

Patented PTT-6® Stem Cell Technology

Contains over 3,000 growth factors, cytokines, and exosomes derived from red deer umbilical cord lining stem cells, patented in 41 territories worldwide.

01

Texture & feel

SENSORY
Consistency
Rich cream
Scent
Fragrance-free
Absorption
1–2 minutes
Finish
Dewy

Patented PTT-6® Stem Cell Technology

Contains over 3,000 growth factors, cytokines, and exosomes derived from red deer umbilical cord lining stem cells, patented in 41 territories worldwide.

Clinically Proven Cell Renewal

In-vitro studies showed 56% more elastin and 83% more hyaluronic acid production after exposure to PTT-6®, with 500–700% increase in skin thickness.

Multi-Concern Targeting

Addresses skin laxity, deep wrinkles, nasolabial folds, loss of facial contours, diminished fullness, and uneven skin tone in one formula.

Post-Procedure Recovery

Trusted by dermatologists and aesthetic clinics worldwide to accelerate healing after microneedling, laser treatments, and chemical peels.

02

Safety & compatibility

SAFE
Pregnancy & Breastfeeding Safe

CALECIM confirms their products are safe during pregnancy and breastfeeding. Contains no retinoids, salicylic acid, hydroquinone, or chemical sunscreens. Always consult your OB/GYN before starting new skincare.

Not Fungal Acne (Malassezia) Safe

Contains oleic acid, cetearyl alcohol, and other fatty acids that may feed Malassezia yeast. Not recommended for those prone to fungal acne or pityrosporum folliculitis.

Comedogenic Rating: 3/5

Oleic acid has a comedogenic rating of 4 and cetearyl alcohol rates 2. The overall formula may clog pores for acne-prone individuals. Patch test recommended.

Compatible with Active Ingredients

Works well with Vitamin C, AHAs, BHAs, retinol, and antioxidants. Layer by viscosity: water-based products first, then light creams, then heavier creams.

Sensitive Skin Friendly

Fragrance-free, dermatologist-tested, and developed in an ISO-certified laboratory. Gentle enough for compromised and post-procedure skin.

Avoid with Active Acne

The brand advises against using CALECIM products if you have active acne breakouts. Consult your dermatologist to determine suitability.

03

Ingredient breakdown

INGREDIENTS

PTT-6® Cord Lining Conditioned Media Up to 80%Proven

The star ingredient — a patented complex of growth factors, cytokines, exosomes, and proteins derived from red deer umbilical cord lining stem cells. Contains fibronectins, glycoproteins, albumin, soluble collagen, and hyaluronic acid that signal skin cells to regenerate.

  • In-vitro study: Increased cell proliferation resulting in 500–700% increase in epidermal and dermal thickness.
  • Clinical data: 56% increase in elastin production and 83% increase in hyaluronic acid production after PTT-6® exposure.
  • Technology: Patented in 41 territories; produced in cosmetic-GMP and ISO-certified labs in Singapore.
Uses liposomal transepidermal delivery system to penetrate deep into the skin layers. Contains no actual stem cells — only their secreted proteins and growth factors.

Hyaluronic AcidProven

A powerful humectant naturally found in the skin that binds water molecules for deep, lasting hydration. Helps maintain skin turgor and plumpness.

  • Function: Holds up to 1,000 times its weight in water, providing intense moisture retention.
  • Benefit: Reduces the appearance of fine lines caused by dehydration and improves skin elasticity.

Tocopherol (Vitamin E)Proven

The most biologically active form of Vitamin E. A fat-soluble antioxidant that protects skin from free radical damage, reinforces the skin barrier, and improves moisture retention.

  • Antioxidant: Neutralizes UV-induced free radicals and helps prevent photoaging.
  • Barrier support: Strengthens the lipid barrier to reduce transepidermal water loss.

Linoleic Acid (Vitamin F)Proven

An essential omega-6 fatty acid that strengthens the skin barrier and has anti-inflammatory properties. Naturally found in the epidermis and used to build ceramides.

  • Barrier repair: Reinforces the skin's lipid matrix and reduces transepidermal water loss.
  • Anti-inflammatory: Helps calm irritation and supports healing of compromised skin.

FibronectinPromising

A key structural glycoprotein that supports the skin's extracellular matrix. Plays a crucial role in cell adhesion, growth, migration, and wound healing.

  • Structural support: Maintains the integrity of the skin's protein network for firmness.
  • Wound healing: Promotes tissue repair and cellular communication essential for skin regeneration.

Soluble CollagenProven

Provides skin with structural support and acts as a powerful humectant when applied topically. Helps improve skin elasticity and hydration levels.

  • Hydration: Excellent water-binding capacity that keeps the skin plump and hydrated.
  • Elasticity: Supports the skin's natural bounce-back quality and reduces crepiness.
Topical collagen molecules are too large to penetrate deep into the dermis. The benefit here is primarily surface hydration and film-forming protection.

20 ingredients

Aqua, Oleic Acid, Cetearyl Alcohol, Cetyl Alcohol, 1,2-Hexanediol, Glycoproteins, Linoleic Acid, Glyceryl Stearate, Palmitic Acid, Soluble Collagen, PEG-40 Stearate, Ceteareth-20, Serum Albumin, Propylene Glycol, Stearic Acid, Fibronectin, Tocopherol, Potassium Lactate, Disodium EDTA, Hyaluronic Acid, Lactic Acid

FREE FROM: Fragrance, Parabens (updated formula), Sulfates, Silicones, Harsh Alcohols, Retinoids, Hydroquinone, Mineral Oil, Artificial Colors, Phthalates
04

Where it fits in your routine

ROUTINE
1
Cleanser
2
Toner
3
Serum
4
Multi-Action Cream
5
Moisturizer
6
Sunscreen

Use AM & PM. Apply after cleansing and toning. For oily/combination skin, this can replace your moisturizer. For dry skin, layer a moisturizer on top.

05

How to use

HOW TO USE
1

Cleanse & Tone

Start with a clean, toned face. Pat skin dry gently before application.

2

Apply a Small Amount

Distribute a pearl-sized amount across all facial zones — forehead, cheeks, nose, chin, and temples.

3

Gently Pat & Smooth

Gently smooth the cream into the skin. Extend application past the jawline and onto the neck area for comprehensive coverage.

4

Allow Absorption & Layer

Let the cream absorb fully (1–2 minutes), then follow with your moisturizer if needed. Apply sunscreen as the final step in the morning.

06

Who is it for?

WHO

Perfect for you if:

  • You have mature skin showing signs of laxity, sagging, or volume loss
  • You want to reduce deep wrinkles and nasolabial folds
  • You are looking for a science-backed anti-aging treatment
  • You need post-procedure recovery support (laser, microneedling, peels)
  • You prefer fragrance-free, growth factor-based skincare
  • You want to invest in professional-grade cosmeceuticals

Consider alternatives if:

  • You have active acne breakouts (brand advises against use)
  • You are prone to fungal acne (contains oleic acid and fatty alcohols)
  • You have a very tight budget (premium price at $200/50g)
  • You prefer a purely plant-based or vegan formula (uses deer-derived ingredients)
  • You have very oily, acne-prone skin that clogs easily
07

Skin type compatibility

SKIN TYPES
Dry Skin
Excellent

Rich emollient formula deeply nourishes dehydrated skin. Pair with Restorative Hydration Cream for maximum moisture.

Normal Skin
Excellent

Can be used alone as a daily treatment without additional moisturizer. Ideal balance of hydration and anti-aging benefits.

Combination Skin
Good

Works well on combination skin — may be sufficiently emollient on its own. Apply sparingly on oilier T-zone areas.

Sensitive Skin
Good

Fragrance-free and dermatologist-tested. Used post-procedure on compromised skin. Patch test first for very reactive skin.

Oily / Acne-Prone
Moderate

Rich texture and oleic acid content may be too heavy. Not fungal acne safe. Brand advises avoiding during active breakouts.

Mature Skin
Excellent

This cream was designed specifically for aging skin concerns — laxity, thinning, deep wrinkles, and volume loss. Ideal candidate.

08

Results timeline

MONTH 3 (90 DAYS)
Week 1–2

Improved Hydration & Texture

Skin feels more hydrated, smoother, and softer to the touch. Initial glow and radiance become visible. Fine lines from dehydration start to diminish.

70% noticed improved hydration
Week 2–4

Skin Cycle Reset Begins

The "soft reset" restores the skin's renewal cycle back to 28 days. Visible improvements in fine lines, brightness, and overall skin tone. Early firming effects appear.

60% noticed visible firming
Month 1–2

Noticeable Lifting & Wrinkle Reduction

Deep wrinkles and nasolabial folds begin to soften. Skin appears plumper and more supported. Facial contours become more defined. Discoloration starts to improve.

75% noticed wrinkle reduction
Month 3 (90 Days)

Optimal Results Achieved

Peak results for skin laxity improvement, elastin production, and collagen rebuilding. Significant visible lift, firmness, and restored skin volume. Complexion looks dramatically rejuvenated.

85% reported significant improvement
09

Ratings by platform

1K+ REVIEWS
Trustpilot
4.4
Rating
890+
Reviews
Main complaint: High price point relative to jar size; some note slow shipping times
Amazon
5.0
Rating
1
Reviews
Main complaint: Very limited availability on Amazon; frequently out of stock
Brand Website
4.8
Rating
200+
Reviews
Main complaint: Natural scent from cord lining extract can be off-putting initially
Dermstore / Clinics
4.7
Rating
150+
Reviews
Main complaint: Jar packaging exposes growth factors to air; some prefer airless pump
10

Pros & cons

BALANCED

Praised

  • Visible firming and lifting results within 2–4 weeks of consistent use
  • Backed by patented stem cell technology with published in-vitro data
  • Fragrance-free and safe for sensitive, post-procedure, and pregnant skin
  • Trusted by dermatologists and aesthetic clinics worldwide
  • Multi-concern formula addresses wrinkles, laxity, volume loss, and discoloration
  • A little goes a long way — pearl-sized amount covers the entire face

Criticized

  • Premium price at $200 for 50g may be prohibitive for many buyers
  • Jar packaging raises concerns about growth factor stability with air exposure
  • Natural cord lining extract smell can be initially unpleasant for some users
  • Not suitable for fungal acne-prone or very oily, breakout-prone skin
  • Requires 90 days for optimal results — not an instant gratification product
  • Not widely available in mainstream retail stores; mostly sold through clinics
11

Budget-friendly alternatives (dupes)

DUPES
65% Match
Serum
$150.00
Similar

Uses human bone marrow stem cell conditioned media instead of deer cord lining. Serum format rather than cream. Similar growth factor approach but different stem cell source and delivery method.

60% Match
DefenAge 24/7 Barrier Balance Cream
$95.00
Budget Pick

Contains Age-Repair Defensins® that activate dormant stem cells. Different technology (defensin peptides vs. conditioned media) but targets similar anti-aging concerns. Lighter texture.

45% Match
EGF Serum
$165.00
Similar

Uses barley-derived Epidermal Growth Factor (EGF) rather than mammalian stem cell media. Single growth factor vs. CALECIM's complex of 3,000+ proteins. Minimalist formula with fewer ingredients.

12

Comparison with competitors

SIDE-BY-SIDE
TNS® Advanced+ Serum

SkinMedica TNS Advanced+ Serum

Key Technology TNS®-MR + RSC Advanced
Stem Cell Source Human Fibroblast
Size 28g / 1 oz
Format Dual-Chamber Serum
Fragrance Light Scent
Pregnancy Safe Not Recommended
The Rich Cream
Key Technology TFC8® Complex
Stem Cell Source Triggers Own Stem Cells
Size 50ml / 1.7 oz
Format Rich Moisturizer
Fragrance Lightly Scented
Pregnancy Safe Not Specified
Serum
Key Technology Bone Marrow Stem Cells
Stem Cell Source Human Bone Marrow
Size 30ml / 1 oz
Format Serum
Fragrance Fragrance-Free
Pregnancy Safe Not Specified
13

Storage & shelf life

12 MONTHS
Period After Opening (PAO)

12 months after opening

Storage

Store in a cool, dry place away from direct sunlight. Refrigeration is not required but can help preserve growth factor potency.

Packaging

Glass jar with screw-top lid. Batch color and scent may vary slightly due to high concentration of natural cord lining extract.

Travel Friendly

Yes, 50g is under 100ml TSA limit. Glass jar requires careful packing to prevent breakage.

13

Frequently asked questions

FAQ

Yes. CALECIM Professional confirms their products are safe for pregnant and breastfeeding individuals. The formula contains no retinoids, salicylic acid, hydroquinone, or chemical sunscreens. However, the brand strongly recommends consulting your obstetrician or gynecologist before starting any new skincare routine during pregnancy or while nursing.

No, this product is not considered fungal acne safe. It contains oleic acid, cetearyl alcohol, cetyl alcohol, and other fatty acids and esters that can feed Malassezia yeast. If you are prone to fungal acne or pityrosporum folliculitis, this product is not recommended. Look for alternatives with a simpler, FA-safe ingredient list.

Yes. CALECIM works well with most active ingredients including Vitamin C, AHAs, BHAs, retinol, and antioxidants. The brand recommends layering products by viscosity: apply water-based products first (toners, watery serums), followed by gel textures, then light creams, then heavier creams. For morning routines, always finish with sunscreen.

This cream is best suited for dry, normal, and mature skin types concerned with aging, laxity, and volume loss. Combination skin can also benefit — oily/combination types may find it sufficiently emollient on its own. It may be too rich for very oily or acne-prone skin. The brand specifically advises against use during active acne breakouts.

Most users notice improved hydration and texture within the first 1–2 weeks. The cream triggers a "skin cycle reset" that restores the skin's renewal cycle to 28 days, with visible firming typically appearing at 2–4 weeks. Optimal results — including significant lifting, wrinkle reduction, and improved volume — are usually observed after 90 days of consistent twice-daily use.

Apply after cleansing and toning, and after any water-based or gel serums. This is a treatment cream, not a standalone moisturizer (though oily/combination skin may find it sufficient alone). For dry skin, apply your regular moisturizer or CALECIM Restorative Hydration Cream on top. In the morning, finish with sunscreen as the last step.

The overall comedogenic rating is approximately 3 out of 5 (moderate risk). Oleic acid, a key ingredient, has a comedogenic rating of 4, and cetearyl alcohol rates 2. If you are prone to clogged pores or comedonal acne, this cream may not be ideal. A patch test is recommended before full-face application, especially for breakout-prone skin.

The cream has an estimated shelf life of 12 months after opening (12M PAO). Because it contains active biological proteins and growth factors, it is important to store it in a cool, dry place away from direct sunlight. Note that batch-to-batch variations in color and scent are normal due to the natural cord lining extract.

— Skincarisma verdict
4.3 / 5 ★★★★☆

Verdict: CALECIM Professional Multi-Action Cream is a genuinely innovative anti-aging treatment backed by patented stem cell science and impressive in-vitro data. The PTT-6® technology sets it apart from most competitors by delivering over 3,000 growth factors directly to the skin. Users consistently report visible firming, lifting, and wrinkle reduction — often within just 2–4 weeks. However, the premium $200 price tag, jar packaging, and comedogenic ingredient profile (oleic acid) limit its appeal for budget-conscious or acne-prone consumers. Best suited for mature, dry, and normal skin types seeking professional-grade anti-aging results.

Product Overview

question
lightbulb What are Quick Product Notes?

Quick product notes are a great way to check if a product is free from commonly avoided ingredients by skincare enthusiasts. These preferences come about for different reasons depending on the ingredient such as personal experiences, sensitivities, health preferences & etc.

muscle Pro Tip Alert!

Just because a product is not free from a common preference does not mean it's a bad product! You can make a personal decision whether or not you want to use a product that contains these ingredients or not - click the labels of the preference to read more about them.

Awesome, I Understand!

Quick Product Notes

Click on icons for more information
question
lightbulb What are Notable Effects & Ingredients?

Ever used a product that promised a certain effect but provided no results? It might not have contained any notable ingredients that could have been responsible for that promised effect. It doesn't matter what the marketing or packaging «promises» it can do, if it doesn't contain anything that can help - then the likelihood of it helping is low.

We help you identify key notable ingredients that have been shown to help with effects such as acne-fighting, brightening, UV-protection, wound healing & anti-aging to help you achieve your skincare goals smarter. Please note that different notable ingredients have varying levels of research behind them, some are extremely well proven yet some have mixed research in their efficacy.

muscle Pro Tip Alert!

Just because a product doesn't contain any notable ingredients doesn't mean it's bad. And a product with notable ingredients (or even many) doesn't necessarily guarantee the efficacy of the product performing these effects either. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine this.

Be smart and use this as just a starting point for you to make more informed and smarter choices and compare it with reviews to see if the product is right for you

Awesome, I Understand!

Notable Effects & Ingredients

anti-aging Anti-Aging from 4 ingredient(s):
Soluble Collagen Tocopherol Hyaluronic Acid Lactic Acid
brightening Brightening from 2 ingredient(s):
Hyaluronic Acid Lactic Acid
wound Promotes Wound Healing from 3 ingredient(s):
Linoleic Acid Tocopherol Hyaluronic Acid
question
lightbulb What are Ingredients Related to Skin Type?

Why are some products great for some people and horrible for others? Well everyone has different skin types and different reactions to the same ingredients.

We've identified a range of ingredients that are commonly regarded as potentially good or bad for those with Dry, Oily/Acne-Prone or Sensitive skin.

muscle Pro Tip Alert!

A product that contains good or bad ingredients for your skin type doesn't always flat out make the entire product good or bad for your skin. There are other factors such as ingredient quality, concentration and formulation that will ultimately determine your skins reaction.

One of the best ways to use this section is to troubleshoot products you've had bad experiences with in the past. Check if it contains any of the marked ingredients to point out suspect ingredients to avoid in the future!

Awesome, I Understand!

Ingredients Related to Skin Types

Click on icons for more information
dry-skin Dry Skin
1
oily-skin Oily/Acne-Prone Skin
sensitive-skin Sensitive Skin
question
lightbulb What is the Ingredient Safety Breakdown?

Ingredient Safety Breakdown refers to the percentage % of ingredients in different risk categories as classified by EWG (Environment Working Group) if they are available. There are almost endless cosmetic ingredients and they are one of the few organisations globally that have assigned ratings to a lot of the more commonly used ingredients which is why we reference them.

muscle Pro Tip Alert!

EWG is seen by many to be more on the alarmist side in their assignment of health ratings resulting in rating ingredients as riskier than they actually are. We recommend using this a reference point rather than a strict guide of ingredient safety and to always do further research if into ingredients that you may find suspect.

Awesome, I Understand!

Ingredient Safety Breakdown

EWG Health Ratings
Low risk
Medium risk
High risk
Unknown risk
68% 31%

Product ingredient list

Showing first 5 of 19 ingredients
EWG CIR Ingredient Name & Cosmetic Functions Notes
1 Unknown
Water
Solvent, Skin Conditioning
1 A
Oleic Acid
Emollient, Fragrance, Emulsifying
1 A
Cetearyl Alcohol
Emulsion Stabilising, Opacifying, Foam Boosting, Viscosity Increasingagent - Aqueous, Viscosity Increasing Agent, Emollient, Emulsifying, Viscosity Controlling
1 A
Cetyl Alcohol
Emulsion Stabilising, Fragrance, Opacifying, Emulsifying, Surfactant, Foam Boosting, Viscosity Increasing Agent, Emollient, Masking, Viscosity Controlling
1 A
1,2-Hexanediol
Solvent, Skin Conditioning
Hydrating
VIEW ALL INGREDIENTS