5% Niacinamide Serum

ADVANCED CLINICALS

Where to buy Possibly in stock

About this product

The ADVANCED CLINICALS 5% Niacinamide Serum is a serums, essence, ampoule. Our analysis of its 22 ingredients (17 low-risk) rates it Excellent (98/100). Based on its ingredients, it looks well-suited to dry and sensitive skin.

Vegan-friendly Reef-safe

Summarised from our ingredient analysis — not brand marketing copy.

At a glance

Type
Serums, Essence, Ampoules
Ingredients
22
Low-risk
17
Fragrance
Fragrance-free
Origin
United States
Data updated
Jun 2026

The evidence

Quick Product Notes

Paraben-Free Sulfate-Free Alcohol-Free Silicone-Free EU Allergen-Free Fungal Acne (Malassezia) Safe

Notable Effects & Ingredients

No Notable Effects & Ingredients

Ingredients Related to Skin Types

Good   Bad — tap a skin type to see which ingredients · estimated from ingredient functions
Dry Skin 7/2
Good for dry skin
Anhydroxylitol Xylitol Xylitylglucoside Caprylic/Capric Triglyceride Sodium Hyaluronate Glycerin Glycol
Caution for dry skin
Xanthan Gum Glycerin
Oily/Acne-Prone Skin No data
Sensitive Skin 4/4
Good for sensitive skin
Glycerin Hydroxyacetophenone Ferulic Acid Aloe Barbadensis Leaf Juice
Caution for sensitive skin
Caprylic/Capric Triglyceride Glycerin Citric Acid Phenoxyethanol

Ingredients list

22 total
Lower hazard (1) Higher hazard (4)
All22 Skin Conditioning15 Humectant8 Solvent4 Fragrance4 Antioxidant3 Viscosity Controlling3 Emulsion Stabilising2 Preservative2
EWG CIR Ingredient Name & Cosmetic Functions Notes
1
Water
(Solvent)
1
A
Niacinamide
(Hair Conditioning, Skin Conditioning, Smoothing)
1
A
Caprylic/Capric Triglyceride
(Emollient, Masking, Perfuming, Skin Conditioning, Solvent)
Pyrus Malus Fruit Extract
(Skin Conditioning)
2
A
Glycerin
(Denaturant, Fragrance, Hair Conditioning, Humectant, Oral Care Agent, Oral Health Care Drug, Skin Protecting, Viscosity Decreasing Agent, Perfuming, Solvent)
Good for Dry Skin
Good for Dry Skin
Fungal Acne
Fungal Acne Trigger
1
Ammonium Acryloyldimethyltaurate/VP Copolymer
(Viscosity Controlling)
1
Xylitylglucoside
(Humectant, Skin Conditioning)
B
Aloe Barbadensis Leaf Juice
(Skin Conditioning)
Good for Sensitive Skin
Good for Sensitive Skin
ASCORBIC ACID
(Antioxidant, Buffering, Fragrance, Skin Conditioning)
1
Anhydroxylitol
(Humectant, Skin Conditioning)
2
Ferulic Acid
(Antioxidant, Preservative, Uv Absorber, Antimicrobial)
4
A
Phenoxyethanol
(Fragrance, Preservative)
Paraben
Paraben
1
A
Xanthan Gum
(Binding Agent, Emulsion Stabilising, Skin Conditioning, Surfactant Emulsifying Agent, Viscosity Increasing Agent, Binding, Gel Forming, Viscosity Controlling)
1
Saccharomyces/Magnesium Ferment
(Not Reported)
3
Saccharomyces/Zinc Ferment
(Skin Conditioning)
1
Hydroxyacetophenone
(Antioxidant)
1
Xylitol
(Flavoring Agent, Humectant, Skin Conditioning)
Glycol
(Humectant, Solvent, Viscosity Controlling)
1
A
Sodium Hyaluronate
(Skin Conditioning, Humectant)
Good for Dry Skin
Good for Dry Skin
1
A
Ethylhexylglycerin
(Deodorant, Skin Conditioning)
2
A
Citric Acid
(Chelating Agent, Fragrance, Ph Adjuster, Buffering Agent, Masking)
Bad for Sensitive Skin
Bad for Sensitive Skin
1
Tetrasodium Glutamate Diacetate
(Chelating Agent)

My Ingredient Notes

No personal ingredient notes yet. Save ingredients to your profile to get good/bad alerts here.

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Key ingredients

Vitamin E
Protects skin and soothes irritation.
Niacinamide
Strengthens, smooths, and brightens skin.
Ceramides
Locks in moisture and supports skin barrier.
Antioxidants
Shields skin from free radical damage.

Benefits

Barrier RepairStrengthen and restore your skin's natural barrier.
HydratingBoosts hydration and relieves dry, tight skin.
Anti-AgingSoftens lines and helps skin look youthful.
BrighteningRestores radiance to dull, tired skin.
Reduces IrritationEases discomfort and supports skin resilience.
Redness ReducingSoothes visible redness and calms irritation.
Scar HealingImproves the look of marks and scars.
Acne FightingFights acne and helps prevent breakouts.

Concerns

Contains paraben
Not fungal acne (malassezia) safe

Ingredients explained

Water
Solvent
Low-hazard ingredient.Read moreShow less
EWG 1 Solvent
Niacinamide
Hair conditioning, Skin conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A Hair conditioningSkin conditioningSmoothing
Caprylic/Capric Triglyceride
Emollient, Masking
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A EmollientMaskingPerfumingSkin conditioningSolvent
Pyrus Malus Fruit Extract
Skin conditioning
Limited public safety data.Read moreShow less
EWG N/A Skin conditioning
Ammonium Acryloyldimethyltaurate/VP Copolymer
Viscosity controlling
Low-hazard ingredient.Read moreShow less
EWG 1 Viscosity controlling
Xylitylglucoside
Humectant, Skin conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 HumectantSkin conditioning
ASCORBIC ACID
Antioxidant, Buffering
Limited public safety data.Read moreShow less
EWG N/A AntioxidantBufferingFragranceSkin conditioning
Anhydroxylitol
Humectant, Skin conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 HumectantSkin conditioning
Ferulic Acid
Antioxidant, Preservative
Low-hazard ingredient.Read moreShow less
EWG 2 AntioxidantPreservativeUv absorberAntimicrobial
Xanthan Gum
Binding agent, Emulsion stabilising
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A Binding agentEmulsion stabilisingSkin conditioningSurfactant -emulsifying agentViscosity increasing agentBindingGel formingViscosity controlling
Saccharomyces/Magnesium Ferment
Not reported
Low-hazard ingredient.Read moreShow less
EWG 1 Not reported
Saccharomyces/Zinc Ferment
Skin conditioning
Low-to-moderate hazard.Read moreShow less
EWG 3 Skin conditioning
Hydroxyacetophenone
Antioxidant
Low-hazard ingredient.Read moreShow less
EWG 1 Antioxidant
Xylitol
Flavoring agent, Humectant
Low-hazard ingredient.Read moreShow less
EWG 1 Flavoring agentHumectantSkin conditioning
Glycol
Humectant, Solvent
Limited public safety data.Read moreShow less
EWG N/A HumectantSolventViscosity controlling
+ 2 more — see the full ingredients list above
Glycerin
Denaturant, Fragrance
Low-hazard ingredient.Read moreShow less
EWG 2 CIR A DenaturantFragranceHair conditioningHumectantOral care agentOral health care drugSkin protectingViscosity decreasing agentPerfumingSolvent Good for Dry SkinFungal-acne trigger
Aloe Barbadensis Leaf Juice
Skin conditioning
Limited public safety data.Read moreShow less
EWG N/A CIR B Skin conditioning Good for Sensitive Skin
Phenoxyethanol
Fragrance, Preservative
Low-to-moderate hazard.Read moreShow less
EWG 4 CIR A FragrancePreservative Paraben
Sodium Hyaluronate
Skin conditioning, Humectant
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A Skin conditioningHumectant Good for Dry Skin
Citric Acid
Chelating agent, Fragrance
Skin irritation can occur at high concentrationRead moreShow less
EWG 2 CIR A Chelating agentFragrancePh adjusterBuffering agentMasking Bad for Sensitive Skin

How to use

How to use

  • 1 Where it fits: Apply after toner and before moisturiser — thinnest to thickest.
  • 2 Morning only: Apply as the last step of your AM routine, after moisturiser, and reapply every ~2 hours of sun exposure.

General guidance from this product's category and active ingredients — always follow the directions on the package.

Trust & honesty

Effective levels — general guide

The concentrations these actives are typically effective at in research — not a measurement of this product.

Vitamin C (ascorbic) 5–20%

L-ascorbic acid is usually used at 5–20% (around 10–15% is common). Above ~20% adds little and tends to irritate more; it also needs a low pH to work.

ASCORBIC ACID

Niacinamide 2–5% (up to 10%)

Most research uses 2–5%; some formulas go to 10%. Very high levels can cause flushing in sensitive skin.

Niacinamide

INCI lists don't disclose amounts, and we don't claim to know this product's levels — these are the ranges these ingredients are usually effective at, so you can tell a real formula from "fairy-dusting" a marketed active. How we estimate this.

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