Retinol Serum Anti-Wrinkle

ADVANCED CLINICALS

Where to buy Possibly in stock

About this product

The ADVANCED CLINICALS Retinol Serum Anti-Wrinkle is a serums, essence, ampoule. Our analysis of its 37 ingredients (18 low-risk) rates it Excellent (86/100). Based on its ingredients, it looks well-suited to oily / acne-prone and dry skin. Heads up: it contains fragrance, which can irritate sensitive or reactive skin.

Vegan-friendly Reef-safe

Summarised from our ingredient analysis — not brand marketing copy.

At a glance

Type
Serums, Essence, Ampoules
Ingredients
37
Low-risk
18
Fragrance
Contains fragrance
Origin
United States
Data updated
May 2026

The evidence

Quick Product Notes

Paraben-Free Sulfate-Free Alcohol-Free Silicone-Free EU Allergen-Free Fungal Acne (Malassezia) Safe

Notable Effects & Ingredients

No Notable Effects & Ingredients

Ingredients Related to Skin Types

Good   Bad — tap a skin type to see which ingredients · estimated from ingredient functions
Dry Skin 6/5
Good for dry skin
Cetearyl Alcohol Squalane Isopropyl Myristate Caprylyl Glycol Glycerin Camellia Sinensis Leaf Extract
Caution for dry skin
Maltodextrin Xanthan Gum Glycerin Hexylene Glycol Camellia Sinensis Leaf Extract
Oily/Acne-Prone Skin 2/0
Good for oily/acne-prone skin
Camellia Sinensis Leaf Extract Retinol
Sensitive Skin 6/13
Good for sensitive skin
Glycerin Camellia Sinensis Leaf Extract Tocopheryl Acetate BHT BHA Aloe Barbadensis Leaf Juice
Caution for sensitive skin
Isopropyl Myristate Glycerin Hexylene Glycol Citric Acid Camellia Sinensis Leaf Extract Phenoxyethanol Linalool Citronellol Limonene BHT Butylphenyl Methylpropional Retinol BHA

Ingredients list

37 total
Lower hazard (1) Higher hazard (9)
All37 Skin Conditioning25 Fragrance13 Emulsion Stabilising8 Perfuming7 Solvent6 Masking6 Hair Conditioning6 Viscosity Controlling6
EWG CIR Ingredient Name & Cosmetic Functions Notes
1
Water
(Solvent)
1
B
Isopropyl Myristate
(Binding Agent, Fragrance, Skin Conditioning, Emollient, Binding, Perfuming, Solvent)
Bad for Oily Skin
Bad for Oily Skin
Fungal Acne
Fungal Acne Trigger
2
A
Glycerin
(Denaturant, Fragrance, Hair Conditioning, Humectant, Oral Care Agent, Oral Health Care Drug, Skin Protecting, Viscosity Decreasing Agent, Perfuming, Solvent)
Good for Dry Skin
Good for Dry Skin
Fungal Acne
Fungal Acne Trigger
Pyrus Malus Fruit Extract
(Skin Conditioning)
1
B
Ethylhexyl Olivate
(Skin Conditioning)
1
A
Cetearyl Alcohol
(Emulsion Stabilising, Opacifying, Foam Boosting, Viscosity Increasingagent Aqueous, Viscosity Increasing Agent, Emollient, Emulsifying, Viscosity Controlling)
B
Aloe Barbadensis Leaf Juice
(Skin Conditioning)
Good for Sensitive Skin
Good for Sensitive Skin
1
A
Squalane
(Emollient, Hair Conditioning, Refatting, Skin Conditioning)
COPERNICIA CERIFERA CERA
(Film Forming, Skin Conditioning, Skin Conditioning Emollient)
9
A
Retinol
(Skin Conditioning)
Bad for Sensitive Skin
Bad for Sensitive Skin
1
Propanediol
(Solvent, Viscosity Decreasing Agent, Viscosity Controlling)
1
A
Sodium Cocoamphoacetate
(Hair Conditioning, Sufactant, Foam Boosting, Foaming)
3
Tocopheryl Acetate
(Antioxidant, Skin Conditioning)
Bad for Oily Skin
Bad for Oily Skin
6
A
BHT
(Antioxidant, Fragrance, Masking)
5
7
BHA
(Antioxidant, Fragrance, Masking)
Bad for Sensitive Skin
Bad for Sensitive Skin
1
A
Xanthan Gum
(Binding Agent, Emulsion Stabilising, Skin Conditioning, Surfactant Emulsifying Agent, Viscosity Increasing Agent, Binding, Gel Forming, Viscosity Controlling)
Oryza Sativa Bran Extract
(Skin Conditioning, Skin Protecting)
rosmarinus officinalis leaf extract
(Antimicrobial, Fragrance, Skin Conditioning)
Helianthus Annuus Extract
(Hair Conditioning, Skin Conditioning, Skin Conditioning Emollient)
TOCOPHEROL
(Antioxidant, Fragrance, Skin Conditioning)
CYAMOPSIS TETRAGONOLOBA GUM
(Binding, Emulsion Stabilising, Film Forming, Fragrance, Viscosity Controlling)
Avena Sativa Bran Extract
(Abrasive)
Citrus Aurantium Dulcis Peel Extract
(Binding, Emulsion Stabilising, Perfuming, Skin Conditioning, Viscosity Controlling)
1
B
Camellia Sinensis Leaf Extract
(Antimicrobial, Antioxidant, Astringent, Emollient, Humectant, Masking, Oral Care Agent, Skin Conditioning, Skin Protecting, Tonic, Uv Absorber)
Good for Oily Skin
Good for Oily Skin
1
Tetrasodium Glutamate Diacetate
(Chelating Agent)
1
Ammonium Acryloyldimethyltaurate/VP Copolymer
(Viscosity Controlling)
2
A
Citric Acid
(Chelating Agent, Fragrance, Ph Adjuster, Buffering Agent, Masking)
Bad for Sensitive Skin
Bad for Sensitive Skin
PARFUM
(Fragrance, Perfuming)
4
A
Phenoxyethanol
(Fragrance, Preservative)
Paraben
Paraben
1
A
Maltodextrin
(Absorbent, Binding Agent, Emulsion Stabilising, Film Forming, Hair Conditioning, Skin Conditioning, Suspending Agent Nonsurfactant, Binding)
1
A
Caprylyl Glycol
(Hair Conditioning, Skin Conditioning, Emollient, Humectant)
1
A
Ethylhexylglycerin
(Deodorant, Skin Conditioning)
1
A
Hexylene Glycol
(Fragrance, Solvent, Viscosity Decreasing Agent, Emulsifying, Perfuming, Skin Conditioning, Surfactant)
7
Butylphenyl Methylpropional
(Perfuming)
Allergens
Allergens
5
Linalool
(Fragrance, Deodorant, Masking)
Allergens
Allergens
6
Limonene
(Deodorant, Perfuming, Solvent)
Allergens
Allergens
5
Citronellol
(Fragrance, Masking)
Allergens
Allergens

My Ingredient Notes

No personal ingredient notes yet. Save ingredients to your profile to get good/bad alerts here.

Browse similar serums, essence, ampoule
No close formula match yet — browse other products like this

Key ingredients

Antioxidants
Shields skin from free radical damage.
Vitamin E
Protects skin and soothes irritation.
Retinoid
Visibly reduces the signs of aging.
Exfoliators
Removes dead skin cells to smoothe texture.

Benefits

HydratingBoosts hydration and relieves dry, tight skin.
Anti-AgingSoftens lines and helps skin look youthful.
BrighteningRestores radiance to dull, tired skin.
Barrier RepairStrengthen and restore your skin's natural barrier.
Redness ReducingSoothes visible redness and calms irritation.
Reduces IrritationEases discomfort and supports skin resilience.
Good For Oily SkinBalances oil and helps reduce shine.
Reduces Large PoresMinimizes the look of enlarged pores.

Concerns

Contains paraben
Contains eu allergen
Not fungal acne (malassezia) safe
Retinol — higher EWG
BHA — higher EWG
Butylphenyl Methylpropional — higher EWG
May not suit sensitive skin

EWG flags hazard, not real-world risk — ratings don't account for how much of an ingredient a product contains. Treat these as things to research, not verdicts. How we score →

Ingredients explained

Water
Solvent
Low-hazard ingredient.Read moreShow less
EWG 1 Solvent
Pyrus Malus Fruit Extract
Skin conditioning
Limited public safety data.Read moreShow less
EWG N/A Skin conditioning
Ethylhexyl Olivate
Skin conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 CIR B Skin conditioning
Cetearyl Alcohol
Emulsion stabilising, Opacifying
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A Emulsion stabilisingOpacifyingFoam boostingViscosity increasingagent - aqueousViscosity increasing agentEmollientEmulsifyingViscosity controlling
Squalane
Emollient, Hair conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A EmollientHair conditioningRefattingSkin conditioning
COPERNICIA CERIFERA CERA
Film forming, Skin conditioning
Limited public safety data.Read moreShow less
EWG N/A Film formingSkin conditioningSkin conditioning emollient
Propanediol
Solvent, Viscosity decreasing agent
Low-hazard ingredient.Read moreShow less
EWG 1 SolventViscosity decreasing agentViscosity controlling
Sodium Cocoamphoacetate
Hair conditioning, Sufactant
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A Hair conditioningSufactantFoam boostingFoaming
Xanthan Gum
Binding agent, Emulsion stabilising
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A Binding agentEmulsion stabilisingSkin conditioningSurfactant -emulsifying agentViscosity increasing agentBindingGel formingViscosity controlling
Oryza Sativa Bran Extract
Skin conditioning, Skin protecting
Limited public safety data.Read moreShow less
EWG N/A Skin conditioningSkin protecting
rosmarinus officinalis leaf extract
Antimicrobial, Fragrance
Limited public safety data.Read moreShow less
EWG N/A AntimicrobialFragranceSkin conditioning
Helianthus Annuus Extract
Hair conditioning, Skin conditioning
Limited public safety data.Read moreShow less
EWG N/A Hair conditioningSkin conditioningSkin conditioning emollient
TOCOPHEROL
Antioxidant, Fragrance
Limited public safety data.Read moreShow less
EWG N/A AntioxidantFragranceSkin conditioning
CYAMOPSIS TETRAGONOLOBA GUM
Binding, Emulsion stabilising
Limited public safety data.Read moreShow less
EWG N/A BindingEmulsion stabilisingFilm formingFragranceViscosity controlling
Avena Sativa Bran Extract
Abrasive
Limited public safety data.Read moreShow less
EWG N/A Abrasive
+ 8 more — see the full ingredients list above
Isopropyl Myristate
Binding agent, Fragrance
Potentially comedogenic - can block poresRead moreShow less
EWG 1 CIR B Binding agentFragranceSkin conditioningEmollientBindingPerfumingSolvent Bad for Oily SkinFungal-acne trigger
Glycerin
Denaturant, Fragrance
Low-hazard ingredient.Read moreShow less
EWG 2 CIR A DenaturantFragranceHair conditioningHumectantOral care agentOral health care drugSkin protectingViscosity decreasing agentPerfumingSolvent Good for Dry SkinFungal-acne trigger
Aloe Barbadensis Leaf Juice
Skin conditioning
Limited public safety data.Read moreShow less
EWG N/A CIR B Skin conditioning Good for Sensitive Skin
Retinol
Skin conditioning
Potentially a skin irritantRead moreShow less
EWG 9 CIR A Skin conditioning Bad for Sensitive Skin
Tocopheryl Acetate
Antioxidant, Skin conditioning
Potentially comedogenic - can block poresRead moreShow less
EWG 3 AntioxidantSkin conditioning Bad for Oily Skin
BHT
Antioxidant, Fragrance
Moderate-hazard ingredient.Read moreShow less
EWG 6 CIR A AntioxidantFragranceMasking
BHA
Antioxidant, Fragrance
Higher-hazard ingredient.Read moreShow less
EWG 5–7 AntioxidantFragranceMasking Bad for Sensitive Skin
Camellia Sinensis Leaf Extract
Antimicrobial, Antioxidant
Low-hazard ingredient.Read moreShow less
EWG 1 CIR B AntimicrobialAntioxidantAstringentEmollientHumectantMaskingOral care agentSkin conditioningSkin protectingTonicUv absorber Good for Oily Skin
Citric Acid
Chelating agent, Fragrance
Skin irritation can occur at high concentrationRead moreShow less
EWG 2 CIR A Chelating agentFragrancePh adjusterBuffering agentMasking Bad for Sensitive Skin
Phenoxyethanol
Fragrance, Preservative
Low-to-moderate hazard.Read moreShow less
EWG 4 CIR A FragrancePreservative Paraben
Butylphenyl Methylpropional
Perfuming
Higher-hazard ingredient.Read moreShow less
EWG 7 Perfuming Allergens
Linalool
Fragrance, Deodorant
Moderate-hazard ingredient.Read moreShow less
EWG 5 FragranceDeodorantMasking Allergens
Limonene
Deodorant, Perfuming
Moderate-hazard ingredient.Read moreShow less
EWG 6 DeodorantPerfumingSolvent Allergens
Citronellol
Fragrance, Masking
Moderate-hazard ingredient.Read moreShow less
EWG 5 FragranceMasking Allergens

How to use

How to use

  • 1 Where it fits: Apply after toner and before moisturiser — thinnest to thickest.
  • 2 Morning only: Apply as the last step of your AM routine, after moisturiser, and reapply every ~2 hours of sun exposure.
  • 3 Wear SPF the next day: Acids and retinoids increase sun sensitivity — daily sunscreen is a must while using this.

General guidance from this product's category and active ingredients — always follow the directions on the package.

Trust & honesty

Pregnancy & breastfeeding

Contains ingredients some choose to avoid or double-check while pregnant or nursing.

Often avoided
Retinoids (Vitamin A) (Retinol)

Topical retinoids (retinol, retinaldehyde, retinyl esters) are widely advised against in pregnancy as a precaution. The strongest evidence is for ORAL retinoids; topical absorption is low, but most clinicians err on the side of caution.

This is general information, not medical advice. Pregnancy guidance varies and depends on concentration and your individual situation — always check with your doctor, midwife or pharmacist. How we flag this.

Effective levels — general guide

The concentrations these actives are typically effective at in research — not a measurement of this product.

Retinoids (Vitamin A) 0.01–1%

Most studied between 0.1% and 1%. Higher is not automatically better — irritation climbs with dose, so a well-formulated lower strength is often the sweet spot.

Retinol

INCI lists don't disclose amounts, and we don't claim to know this product's levels — these are the ranges these ingredients are usually effective at, so you can tell a real formula from "fairy-dusting" a marketed active. How we estimate this.

From the community

0
Reviews
0
Saved by users
0
In collections

Ratings & reviews

Write a Review
0.0
from 0 ratings

Used this product? Rate it in 10 seconds

Alternatives