8 In 1 Bioserum

DefenAge

Where to buy Possibly in stock

About this product

The DefenAge 8 In 1 Bioserum is a serums, essence, ampoule. Our analysis of its 38 ingredients (30 low-risk) rates it Excellent (99/100). Based on its ingredients, it looks well-suited to dry and sensitive skin.

Vegan-friendly Reef-safe

Summarised from our ingredient analysis — not brand marketing copy.

At a glance

Type
Serums, Essence, Ampoules
Ingredients
38
Low-risk
30
Fragrance
Fragrance-free
Origin
United States
Data updated
Jun 2026

The evidence

Quick Product Notes

Paraben-Free Sulfate-Free Alcohol-Free Silicone-Free EU Allergen-Free Fungal Acne (Malassezia) Safe

Notable Effects & Ingredients

No Notable Effects & Ingredients

Ingredients Related to Skin Types

Good   Bad — tap a skin type to see which ingredients · estimated from ingredient functions
Dry Skin 9/5
Good for dry skin
Alanyl Glutamine Octyldodecanol Caprylyl Glycol Sodium Hyaluronate Glycerin Serum Albumin Dimethicone Cyclopentasiloxane Lecithin
Caution for dry skin
Glycerin Hexylene Glycol Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone Polysorbate 20 Lecithin
Oily/Acne-Prone Skin No data
Sensitive Skin 8/6
Good for sensitive skin
Alpha-Arbutin Arabidopsis Thaliana Extract Ergothioneine Ubiquinone Glycerin Dimethicone Tocopheryl Acetate Epigallocatechin Gallatyl Glucoside
Caution for sensitive skin
Sodium Chloride Octyldodecanol Glycerin Hydroxypropyl Cyclodextrin Hexylene Glycol Phenoxyethanol

Ingredients list

38 total
Lower hazard (1) Higher hazard (4)
All38 Skin Conditioning35 Antioxidant7 Fragrance7 Hair Conditioning6 Emollient6 Humectant6 Solvent5 Viscosity Controlling4
EWG CIR Ingredient Name & Cosmetic Functions Notes
1
Water
(Solvent)
3
A
Cyclopentasiloxane
(Hair Conditioning, Skin Conditioning, Emollient, Solvent)
Silicone
Silicone
2
A
Glycerin
(Denaturant, Fragrance, Hair Conditioning, Humectant, Oral Care Agent, Oral Health Care Drug, Skin Protecting, Viscosity Decreasing Agent, Perfuming, Solvent)
Good for Dry Skin
Good for Dry Skin
Fungal Acne
Fungal Acne Trigger
1
A
Niacinamide
(Hair Conditioning, Skin Conditioning, Smoothing)
Sinorhizobium Meliloti Ferment Filtrate
(Skin Conditioning)
1
A
Octyldodecanol
(Fragrance, Skin Conditioning, Emollient, Perfuming, Solvent)
3
A
Dimethicone
(Antifoaming Agent, Skin Protecting, Emollient, Skin Conditioning)
Silicone
Silicone
3
B
Polysorbate 20
(Emulsifying, Surfactant)
Fungal Acne
Fungal Acne Trigger
1
A
Dimethicone/Vinyl Dimethicone Crosspolymer
(Viscosity Controlling)
3
A
Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone
(Hair Conditioning, Skin Conditioning, Surfactant)
1
Ammonium Acryloyldimethyltaurate/VP Copolymer
(Viscosity Controlling)
1
A
Phospholipids
(Skin Conditioning)
1
Alpha-Arbutin
(Antioxidant, Skin Conditioning)
1
Palmitoyl Tripeptide-38
(Skin Conditioning)
1
A
Sodium Hyaluronate
(Skin Conditioning, Humectant)
Good for Dry Skin
Good for Dry Skin
1
Arabidopsis Thaliana Extract
(Antioxidant)
RIBES NIGRUM SEED OIL
(Skin Conditioning Emollient)
HELIANTHUS ANNUUS SEED OIL UNSAPONIFIABLES
(Skin Conditioning Emollient)
1
Cardiospermum Halicacabum Flower/Leaf/Vine Extract
(Skin Conditioning)
1
Ergothioneine
(Antioxidant)
rosmarinus officinalis leaf extract
(Antimicrobial, Fragrance, Skin Conditioning)
Helianthus Annuus Seed Oil
(Fragrance, Skin Conditioning, Skin Conditioning Emollient)
3
Tocopheryl Acetate
(Antioxidant, Skin Conditioning)
Bad for Oily Skin
Bad for Oily Skin
1
Ubiquinone
(Antioxidant, Skin Conditioning)
1
Leuconostoc/Radish Root Ferment Filtrate
(Antidandruff Agent, Antimicrobial)
TOCOPHEROL
(Antioxidant, Fragrance, Skin Conditioning)
Epigallocatechin Gallatyl Glucoside
(Antioxidant, Skin Conditioning)
2
Serum Albumin
(Film Forming, Hair Conditioning, Skin Conditioning, Humectant)
1
Alanyl Glutamine
(Humectant, Skin Conditioning, Emollient)
1
A
Cetyl Hydroxyethylcellulose
(Emulsion Stabilising, Viscosity Increasing Agent, Film Forming, Viscosity Controlling)
2
3
Lecithin
(Skin Conditioning, Emulsifying, Surfactant, Antistatic Agent, Emollient)
1
A
Hydroxypropyl Cyclodextrin
(Chelating Agent, Emulsion Stabilising, Masking, Skin Conditioning)
1
Phytic Acid
(Chelating Agent, Oral Care Agent)
4
A
Phenoxyethanol
(Fragrance, Preservative)
Paraben
Paraben
1
A
Caprylyl Glycol
(Hair Conditioning, Skin Conditioning, Emollient, Humectant)
1
A
Ethylhexylglycerin
(Deodorant, Skin Conditioning)
1
A
Hexylene Glycol
(Fragrance, Solvent, Viscosity Decreasing Agent, Emulsifying, Perfuming, Skin Conditioning, Surfactant)
1
Sodium Chloride
(Bulking Agent, Masking, Oral Care Agent, Viscosity Controlling)

My Ingredient Notes

No personal ingredient notes yet. Save ingredients to your profile to get good/bad alerts here.

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Key ingredients

Antioxidants
Shields skin from free radical damage.
Vitamin E
Protects skin and soothes irritation.
Niacinamide
Strengthens, smooths, and brightens skin.
Hyaluronic Acid
Hydrates by attracting and holding water.
Peptides
Supports skin hydration and improves firmness.

Benefits

HydratingBoosts hydration and relieves dry, tight skin.
Barrier RepairStrengthen and restore your skin's natural barrier.
Anti-AgingSoftens lines and helps skin look youthful.
Redness ReducingSoothes visible redness and calms irritation.
BrighteningRestores radiance to dull, tired skin.
Reduces IrritationEases discomfort and supports skin resilience.
Scar HealingImproves the look of marks and scars.
Dark SpotsFades dark spots for even skin tone.

Concerns

Contains paraben
Contains silicone
Not fungal acne (malassezia) safe

Ingredients explained

Water
Solvent
Low-hazard ingredient.Read moreShow less
EWG 1 Solvent
Niacinamide
Hair conditioning, Skin conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A Hair conditioningSkin conditioningSmoothing
Sinorhizobium Meliloti Ferment Filtrate
Skin conditioning
Limited public safety data.Read moreShow less
EWG N/A Skin conditioning
Octyldodecanol
Fragrance, Skin conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A FragranceSkin conditioningEmollientPerfumingSolvent
Dimethicone/Vinyl Dimethicone Crosspolymer
Viscosity controlling
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A Viscosity controlling
Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone
Hair conditioning, Skin conditioning
Low-to-moderate hazard.Read moreShow less
EWG 3 CIR A Hair conditioningSkin conditioningSurfactant
Ammonium Acryloyldimethyltaurate/VP Copolymer
Viscosity controlling
Low-hazard ingredient.Read moreShow less
EWG 1 Viscosity controlling
Phospholipids
Skin conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A Skin conditioning
Alpha-Arbutin
Antioxidant, Skin conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 AntioxidantSkin conditioning
Palmitoyl Tripeptide-38
Skin conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 Skin conditioning
Arabidopsis Thaliana Extract
Antioxidant
Low-hazard ingredient.Read moreShow less
EWG 1 Antioxidant
RIBES NIGRUM SEED OIL
Skin conditioning emollient
Limited public safety data.Read moreShow less
EWG N/A Skin conditioning emollient
HELIANTHUS ANNUUS SEED OIL UNSAPONIFIABLES
Skin conditioning emollient
Limited public safety data.Read moreShow less
EWG N/A Skin conditioning emollient
Cardiospermum Halicacabum Flower/Leaf/Vine Extract
Skin conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 Skin conditioning
Ergothioneine
Antioxidant
Low-hazard ingredient.Read moreShow less
EWG 1 Antioxidant
+ 16 more — see the full ingredients list above
Cyclopentasiloxane
Hair conditioning, Skin conditioning
Low-to-moderate hazard.Read moreShow less
EWG 3 CIR A Hair conditioningSkin conditioningEmollientSolvent Silicone
Glycerin
Denaturant, Fragrance
Low-hazard ingredient.Read moreShow less
EWG 2 CIR A DenaturantFragranceHair conditioningHumectantOral care agentOral health care drugSkin protectingViscosity decreasing agentPerfumingSolvent Good for Dry SkinFungal-acne trigger
Dimethicone
Antifoaming agent, Skin protecting
Low-to-moderate hazard.Read moreShow less
EWG 3 CIR A Antifoaming agentSkin protectingEmollientSkin conditioning Silicone
Polysorbate 20
Emulsifying, Surfactant
Low-to-moderate hazard.Read moreShow less
EWG 3 CIR B EmulsifyingSurfactant Fungal-acne trigger
Sodium Hyaluronate
Skin conditioning, Humectant
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A Skin conditioningHumectant Good for Dry Skin
Tocopheryl Acetate
Antioxidant, Skin conditioning
Potentially comedogenic - can block poresRead moreShow less
EWG 3 AntioxidantSkin conditioning Bad for Oily Skin
Phenoxyethanol
Fragrance, Preservative
Low-to-moderate hazard.Read moreShow less
EWG 4 CIR A FragrancePreservative Paraben

How to use

How to use

  • 1 Where it fits: Apply after toner and before moisturiser — thinnest to thickest.
  • 2 Morning & evening: Suitable for both AM and PM use.

General guidance from this product's category and active ingredients — always follow the directions on the package.

Trust & honesty

Effective levels — general guide

The concentrations these actives are typically effective at in research — not a measurement of this product.

Niacinamide 2–5% (up to 10%)

Most research uses 2–5%; some formulas go to 10%. Very high levels can cause flushing in sensitive skin.

Niacinamide

INCI lists don't disclose amounts, and we don't claim to know this product's levels — these are the ranges these ingredients are usually effective at, so you can tell a real formula from "fairy-dusting" a marketed active. How we estimate this.

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