Niacinamide 377 VC Brightening Serum

Dr.Leo

Where to buy Possibly in stock

About this product

The Dr.Leo Niacinamide 377 VC Brightening Serum is a serums, essence, ampoule. Our analysis of its 55 ingredients (44 low-risk) rates it Excellent (99/100). Based on its ingredients, it looks well-suited to dry skin. Heads up: it contains fragrance, which can irritate sensitive or reactive skin.

Vegan-friendly Reef-safe

Summarised from our ingredient analysis — not brand marketing copy.

At a glance

Type
Serums, Essence, Ampoules
Ingredients
55
Low-risk
44
Fragrance
Contains fragrance
Origin
United States
Data updated
Jun 2026

The evidence

Quick Product Notes

Paraben-Free Sulfate-Free Alcohol-Free Silicone-Free EU Allergen-Free Fungal Acne (Malassezia) Safe

Notable Effects & Ingredients

No Notable Effects & Ingredients

Ingredients Related to Skin Types

Good   Bad — tap a skin type to see which ingredients · estimated from ingredient functions
Dry Skin 10/7
Good for dry skin
Mannitol Methyl Gluceth-20 Acetyl Hexapeptide-8 Butylene Glycol Sodium Hyaluronate Glycerin Propylene Glycol Phaeodactylum Tricornutum Extract Dimethicone Lecithin
Caution for dry skin
Glycerin Trideceth-9 Hydrogenated Lecithin Steareth-20 PEG-40 Hydrogenated Castor Oil Silica Lecithin
Oily/Acne-Prone Skin No data
Sensitive Skin 7/10
Good for sensitive skin
Sodium Ascorbate Ergothioneine Glycerin Phaeodactylum Tricornutum Extract Phenylethyl Resorcinol Hydroxyacetophenone Dimethicone
Caution for sensitive skin
Dipropylene Glycol Mannitol Butylene Glycol Glycerin Propylene Glycol Citric Acid Tromethamine PEG-40 Hydrogenated Castor Oil Phenoxyethanol Sclareolide

Ingredients list

55 total
Lower hazard (1) Higher hazard (4)
All55 Skin Conditioning39 Humectant12 Fragrance10 Viscosity Controlling10 Solvent8 Hair Conditioning7 Masking6 Surfactant5
EWG CIR Ingredient Name & Cosmetic Functions Notes
1
Water
(Solvent)
1
A
Dipropylene Glycol
(Fragrance, Solvent, Viscosity Decreasing Agent, Masking, Viscosity Controlling)
1
A
Methyl Gluceth-20
(Humectant, Moisturising)
3
A
Dimethicone
(Antifoaming Agent, Skin Protecting, Emollient, Skin Conditioning)
Silicone
Silicone
1
A
Butylene Glycol
(Fragrance, Skin Conditioning, Solvent, Viscositydecreasing Agent, Humectant, Masking, Viscosity Controlling)
Good for Dry Skin
Good for Dry Skin
4
A
Phenoxyethanol
(Fragrance, Preservative)
Paraben
Paraben
1
Cornus Officinalis Fruit Extract
(Skin Conditioning)
2
A
Glycerin
(Denaturant, Fragrance, Hair Conditioning, Humectant, Oral Care Agent, Oral Health Care Drug, Skin Protecting, Viscosity Decreasing Agent, Perfuming, Solvent)
Good for Dry Skin
Good for Dry Skin
Fungal Acne
Fungal Acne Trigger
1
A
1,2-Hexanediol
(Solvent)
1
Ammonium Acryloyldimethyltaurate/VP Copolymer
(Viscosity Controlling)
1
A
Niacinamide
(Hair Conditioning, Skin Conditioning, Smoothing)
1
Hydroxyacetophenone
(Antioxidant)
1
1-Methylhydantoin-2-Imide
(Skin Conditioning)
1
Propanediol
(Solvent, Viscosity Decreasing Agent, Viscosity Controlling)
1
A
Carbomer
(Emulsion Stabilising, Viscosity Increasing Agent, Gel Forming, Viscosity Controlling)
2
A
Tromethamine
(Fragrance, Ph Adjuster, Buffering Agent, Masking)
1
Polyacrylate Crosspolymer-6
(Emulsion Stabilising, Viscosity Controlling)
1
Sodium Polyacryloyldimethyl Taurate
(Emulsion Stabilising, Viscosity Increasing Agent, Viscosity Controlling)
1
A
Ethylhexylglycerin
(Deodorant, Skin Conditioning)
1
Arginine Ferulate
(Skin Conditioning)
1
A
Pentylene Glycol
(Skin Conditioning, Solvent)
1
Paeonia Albiflora Root Extract
(Skin Conditioning)
1
A
Disodium EDTA
(Chelating Agent, Viscosity Controlling)
1
Phaeodactylum Tricornutum Extract
(Humectant, Soothing)
3
B
PEG-40 Hydrogenated Castor Oil
(Fragrance, Emulsifying, Surfactant, Perfuming)
Fungal Acne
Fungal Acne Trigger
2
3
Lecithin
(Skin Conditioning, Emulsifying, Surfactant, Antistatic Agent, Emollient)
3
B
Steareth-20
(Sufactant, Emulsifying, Surfactant)
Tremella Fuciformis Extract
(Humectant, Skin Conditioning)
2
A
Hydrogenated Lecithin
(Skin Conditioning, Emulsifying, Surfactant, Suspending Agent Nonsurfactant)
1
A
Sodium Hyaluronate
(Skin Conditioning, Humectant)
Good for Dry Skin
Good for Dry Skin
1
B
Trideceth-9
(Emulsifying, Surfactant)
1
A
Sodium Ascorbate
(Antioxidant)
Magnolia Sieboldii Extract
(Skin Conditioning)
1
A
Tripeptide-1
(Skin Conditioning)
1
Ceramide NP
(Hair Conditioning, Skin Conditioning)
Sclareolide
(Masking, Perfuming, Skin Conditioning)
1
Phenylethyl Resorcinol
(Antioxidant)
3
B
Propylene Glycol
(Fragrance, Humectant, Skin Conditioningagent Miscellaneous, Solvent, Viscosity Decreasing Agent, Skin Conditioning, Viscosity Controlling)
Good for Dry Skin
Good for Dry Skin
1
Undecylenoyl Phenylalanine
(Skin Conditioning)
PARFUM
(Fragrance, Perfuming)
1
Mannitol
(Binding Agent, Flavoring Agent, Humectant, Binding, Masking, Moisturising, Skin Conditioning)
1
Acetyl Tetrapeptide-9
(Skin Conditioning)
1
Hexapeptide-9
(Skin Conditioning)
Glabridin
(Bleaching)
TOCOPHEROL
(Antioxidant, Fragrance, Skin Conditioning)
1
Palmitoyl Pentapeptide-4
(Skin Conditioning)
1
Acetyl Hexapeptide-8
(Humectant, Skin Conditioning)
1
A
Palmitoyl Tetrapeptide-7
(Skin Conditioning)
2
A
Citric Acid
(Chelating Agent, Fragrance, Ph Adjuster, Buffering Agent, Masking)
Bad for Sensitive Skin
Bad for Sensitive Skin
Ceramide NS
(Hair Conditioning, Skin Conditioning)
Ceramide AS
(Hair Conditioning, Skin Conditioning)
1
Ergothioneine
(Antioxidant)
1
2
A
Silica
(Abrasive, Absorbent, Anticaking Agent, Bulking Agent, Opacifying, Viscosity Controlling)
Ceramide AP
(Hair Conditioning, Skin Conditioning)
Ceramide EOP
(Hair Conditioning, Skin Conditioning)

My Ingredient Notes

No personal ingredient notes yet. Save ingredients to your profile to get good/bad alerts here.

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Key ingredients

Peptides
Supports skin hydration and improves firmness.
Ceramides
Locks in moisture and supports skin barrier.
Antioxidants
Shields skin from free radical damage.
Vitamin C
Brightens, evens tone, and supports collagen.
Vitamin E
Protects skin and soothes irritation.
Niacinamide
Strengthens, smooths, and brightens skin.
Hyaluronic Acid
Hydrates by attracting and holding water.
Exfoliators
Removes dead skin cells to smoothe texture.

Benefits

HydratingBoosts hydration and relieves dry, tight skin.
Barrier RepairStrengthen and restore your skin's natural barrier.
Anti-AgingSoftens lines and helps skin look youthful.
Redness ReducingSoothes visible redness and calms irritation.
Reduces IrritationEases discomfort and supports skin resilience.
Dark SpotsFades dark spots for even skin tone.
BrighteningRestores radiance to dull, tired skin.
Scar HealingImproves the look of marks and scars.

Concerns

Contains paraben
Contains silicone
Not fungal acne (malassezia) safe
May not suit sensitive skin

Ingredients explained

Water
Solvent
Low-hazard ingredient.Read moreShow less
EWG 1 Solvent
Dipropylene Glycol
Fragrance, Solvent
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A FragranceSolventViscosity decreasing agentMaskingViscosity controlling
Methyl Gluceth-20
Humectant, Moisturising
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A HumectantMoisturising
Cornus Officinalis Fruit Extract
Skin conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 Skin conditioning
1,2-Hexanediol
Solvent
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A Solvent
Ammonium Acryloyldimethyltaurate/VP Copolymer
Viscosity controlling
Low-hazard ingredient.Read moreShow less
EWG 1 Viscosity controlling
Niacinamide
Hair conditioning, Skin conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A Hair conditioningSkin conditioningSmoothing
Hydroxyacetophenone
Antioxidant
Low-hazard ingredient.Read moreShow less
EWG 1 Antioxidant
1-Methylhydantoin-2-Imide
Skin conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 Skin conditioning
Propanediol
Solvent, Viscosity decreasing agent
Low-hazard ingredient.Read moreShow less
EWG 1 SolventViscosity decreasing agentViscosity controlling
Carbomer
Emulsion stabilising, Viscosity increasing agent
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A Emulsion stabilisingViscosity increasing agentGel formingViscosity controlling
Tromethamine
Fragrance, Ph adjuster
Low-hazard ingredient.Read moreShow less
EWG 2 CIR A FragrancePh adjusterBuffering agentMasking
Polyacrylate Crosspolymer-6
Emulsion stabilising, Viscosity controlling
Low-hazard ingredient.Read moreShow less
EWG 1 Emulsion stabilisingViscosity controlling
Sodium Polyacryloyldimethyl Taurate
Emulsion stabilising, Viscosity increasing agent
Low-hazard ingredient.Read moreShow less
EWG 1 Emulsion stabilisingViscosity increasing agentViscosity controlling
Ethylhexylglycerin
Deodorant, Skin conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A DeodorantSkin conditioning
+ 32 more — see the full ingredients list above
Dimethicone
Antifoaming agent, Skin protecting
Low-to-moderate hazard.Read moreShow less
EWG 3 CIR A Antifoaming agentSkin protectingEmollientSkin conditioning Silicone
Butylene Glycol
Fragrance, Skin conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A FragranceSkin conditioningSolventViscositydecreasing agentHumectantMaskingViscosity controlling Good for Dry Skin
Phenoxyethanol
Fragrance, Preservative
Low-to-moderate hazard.Read moreShow less
EWG 4 CIR A FragrancePreservative Paraben
Glycerin
Denaturant, Fragrance
Low-hazard ingredient.Read moreShow less
EWG 2 CIR A DenaturantFragranceHair conditioningHumectantOral care agentOral health care drugSkin protectingViscosity decreasing agentPerfumingSolvent Good for Dry SkinFungal-acne trigger
PEG-40 Hydrogenated Castor Oil
Fragrance, Emulsifying
Low-to-moderate hazard.Read moreShow less
EWG 3 CIR B FragranceEmulsifyingSurfactantPerfuming Fungal-acne trigger
Sodium Hyaluronate
Skin conditioning, Humectant
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A Skin conditioningHumectant Good for Dry Skin
Propylene Glycol
Fragrance, Humectant
Low-to-moderate hazard.Read moreShow less
EWG 3 CIR B FragranceHumectantSkin-conditioningagent - miscellaneousSolventViscosity decreasing agentSkin conditioningViscosity controlling Good for Dry Skin
Citric Acid
Chelating agent, Fragrance
Skin irritation can occur at high concentrationRead moreShow less
EWG 2 CIR A Chelating agentFragrancePh adjusterBuffering agentMasking Bad for Sensitive Skin

How to use

How to use

  • 1 Where it fits: Apply after toner and before moisturiser — thinnest to thickest.
  • 2 Morning works well: Antioxidants like vitamin C pair well with daytime use under sunscreen.

General guidance from this product's category and active ingredients — always follow the directions on the package.

Trust & honesty

Officially notified as a cosmetic in Malaysia (NPRA). Government registration record.

Effective levels — general guide

The concentrations these actives are typically effective at in research — not a measurement of this product.

Vitamin C (ascorbic) 5–20%

L-ascorbic acid is usually used at 5–20% (around 10–15% is common). Above ~20% adds little and tends to irritate more; it also needs a low pH to work.

Sodium Ascorbate

Niacinamide 2–5% (up to 10%)

Most research uses 2–5%; some formulas go to 10%. Very high levels can cause flushing in sensitive skin.

Niacinamide

INCI lists don't disclose amounts, and we don't claim to know this product's levels — these are the ranges these ingredients are usually effective at, so you can tell a real formula from "fairy-dusting" a marketed active. How we estimate this.

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