Estee Lauder Clear Difference Advanced Blemish Serum
The Estee Lauder Clear Difference Advanced Blemish Serum is a serums, essence, ampoule. Our analysis of its 30 ingredients (24 low-risk) rates it Excellent (91/100). Based on its ingredients, it looks well-suited to oily / acne-prone and dry skin. Heads up: it contains fragrance, which can irritate sensitive or reactive skin.
The Estee Lauder Clear Difference Advanced Blemish Serum is a serums, essence, ampoule. Our analysis of its 30 ingredients (24 low-risk) rates it Excellent (91/100). Based on its ingredients, it looks well-suited to oily / acne-prone and dry skin. Heads up: it contains fragrance, which can irritate sensitive or reactive skin.
Summarised from our ingredient analysis — not brand marketing copy.
The evidence
| EWG | CIR | Ingredient Name & Cosmetic Functions | Notes |
|---|---|---|---|
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Salicylic Acid
(Antiacne Agent, Antidandruff Agent, Corn/Callus/Wart Remover, Denaturant, Exfoliant, Fragrance, Hair Conditioning, Skin Conditioning, Keratolytic, Masking, Preservative) |
Good for Oily Skin
Bad for Sensitive Skin
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Dimethicone
(Antifoaming Agent, Skin Protecting, Emollient, Skin Conditioning) |
Silicone
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Hamamelis Virginiana (Witch Hazel) Water
(Drug Astringent Skin Protecting, Skin Conditioning) |
Good for Oily Skin
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PPG-14 Butyl Ether
(Hair Conditioning, Skin Conditioning) |
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Acetyl Glucosamine
(Skin Conditioning) |
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Sucrose
(Flavoring Agent, Humectant, Skin Conditioning, Soothing) |
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Isodecyl Neopentanoate
(Skin Conditioning, Emollient) |
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Steareth-21
(Sufactant, Emulsifying, Surfactant) |
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Glycine
(Buffering Agent, Fragrance, Hair Conditioning, Skin Conditioning Agent Miscellaneous, Antistatic Agent, Skin Conditioning) |
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Acrylamide/Sodium Acryloyldimethyltaurate Copolymer
(Emulsion Stabilising, Viscosity Controlling) |
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Laminaria Digitata | |
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Laminaria Saccharina Extract
(Skin Protecting) |
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Caffeine
(Fragrance, Skin Conditioning, Masking) |
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Tocopheryl Acetate
(Antioxidant, Skin Conditioning) |
Bad for Oily Skin
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Isohexadecane
(Skin Conditioning, Emollient, Solvent) |
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Steareth-2
(Emulsifying, Surfactant) |
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Algae Extract
(Fragrance, Humectant, Oral Care Agent, Skin Conditioning, Emollient) |
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Sodium Hyaluronate
(Skin Conditioning, Humectant) |
Good for Dry Skin
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Polysorbate 80
(Denaturant, Emulsifying, Surfactant) |
Fungal Acne Trigger
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Quaternium-22
(Antistatic Agent, Film Forming, Hair Conditioning) |
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Butylene Glycol
(Fragrance, Skin Conditioning, Solvent, Viscositydecreasing Agent, Humectant, Masking, Viscosity Controlling) |
Good for Dry Skin
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Sodium Hydroxide
(Denaturant, Ph Adjuster, Buffering Agent) |
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Pentylene Glycol
(Skin Conditioning, Solvent) |
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Disodium EDTA
(Chelating Agent, Viscosity Controlling) |
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Fragrance
(Deodorant, Masking, Perfuming) |
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Linalool
(Fragrance, Deodorant, Masking) |
Allergens
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Phenoxyethanol
(Fragrance, Preservative) |
Paraben
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Benzalkonium Chloride
(Antimicrobial Agent, Antistatic Agent, Cosmetic Biocide, Deodorant, Surfactant Suspending Agent, Preservative) |
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Green 3 | |
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Yellow 5 Lake |
No personal ingredient notes yet. Save ingredients to your profile to get good/bad alerts here.
EWG flags hazard, not real-world risk — ratings don't account for how much of an ingredient a product contains. Treat these as things to research, not verdicts. How we score →
How to use
General guidance from this product's category and active ingredients — always follow the directions on the package.
Trust & honesty
Contains ingredients some choose to avoid or double-check while pregnant or nursing.
Low-strength topical salicylic acid (BHA) is generally considered fine. Caution is usually reserved for high-strength leave-on products and salicylic peels.
This is general information, not medical advice. Pregnancy guidance varies and depends on concentration and your individual situation — always check with your doctor, midwife or pharmacist. How we flag this.
The concentrations these actives are typically effective at in research — not a measurement of this product.
Salicylic acid is OTC-capped at 2%; 0.5–2% is the usual leave-on range. Much below that it acts more as a soothing agent than an exfoliant.
Salicylic Acid
INCI lists don't disclose amounts, and we don't claim to know this product's levels — these are the ranges these ingredients are usually effective at, so you can tell a real formula from "fairy-dusting" a marketed active. How we estimate this.
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