iS Clinical Pro-Heal Serum Advance Plus

iS Clinical

Where to buy Possibly in stock

About this product

The iS Clinical Pro-Heal Serum Advance Plus is a serums, essence, ampoule. Our analysis of its 16 ingredients (12 low-risk) rates it Excellent (85/100). Based on its ingredients, it looks well-suited to oily / acne-prone skin.

Vegan-friendly Reef-safe

Summarised from our ingredient analysis — not brand marketing copy.

At a glance

Type
Serums, Essence, Ampoules
Ingredients
16
Low-risk
12
Fragrance
Fragrance-free
Origin
United States

The evidence

Quick Product Notes

Paraben-Free Sulfate-Free Alcohol-Free Silicone-Free EU Allergen-Free Fungal Acne (Malassezia) Safe

Notable Effects & Ingredients

No Notable Effects & Ingredients

Ingredients Related to Skin Types

Good   Bad — tap a skin type to see which ingredients · estimated from ingredient functions
Dry Skin 2/5
Good for dry skin
Glycerin Propylene Glycol
Caution for dry skin
Glycerin Polysorbate 20 Alcohol Denat. Zinc Sulfate Laureth-4
Oily/Acne-Prone Skin 4/0
Good for oily/acne-prone skin
Ascorbic Acid (Vitamin C) Alcohol Denat. Zinc Sulfate Retinol
Sensitive Skin 5/7
Good for sensitive skin
Arbutin Bioflavonoids Polyporus Umbellatus (Mushroom) Extract Glycerin Ascorbic Acid (Vitamin C)
Caution for sensitive skin
Glycerin Propylene Glycol Ascorbic Acid (Vitamin C) Alcohol Denat. Phenoxyethanol Retinol Laureth-4

Ingredients list

16 total
Lower hazard (1) Higher hazard (9)
All16 Skin Conditioning10 Solvent5 Humectant4 Fragrance4 Masking3 Oral Care Agent2 Skin Protecting2 Viscosity Decreasing Agent2
EWG CIR Ingredient Name & Cosmetic Functions Notes
1
Water
(Solvent)
1
A
Ascorbic Acid (Vitamin C)
(Antioxidant, Fragrance, Ph Adjuster, Skin Conditioning, Buffering Agent, Masking)
Good for Dry Skin
Good for Dry Skin
2
3
B
Laureth-4
(Antistatic Agent, Emulsifying, Masking, Surfactant)
Bad for Oily Skin
Bad for Oily Skin
4
Alcohol Denat.
(Antifoaming Agent, Antimicrobial, Astringent, Masking, Solvent, Viscosity Controlling)
Bad for Dry Skin
Bad for Dry Skin
Bad for Sensitive Skin
Bad for Sensitive Skin
1
A
Pentylene Glycol
(Skin Conditioning, Solvent)
3
B
Propylene Glycol
(Fragrance, Humectant, Skin Conditioningagent Miscellaneous, Solvent, Viscosity Decreasing Agent, Skin Conditioning, Viscosity Controlling)
Good for Dry Skin
Good for Dry Skin
1
Olea Europaea (Olive) Leaf Extract
(Skin Conditioning)
4
Zinc Sulfate
(Cosmetic Astringent, Cosmetic Biocide, Oral Care Agent, Antimicrobial, Antiplaque)
1
Tocopherol (Vitamin E) Good for Dry Skin
Good for Dry Skin
1
Polyporus Umbellatus (Mushroom) Extract
(Skin Protecting)
1
Arbutin
(Antioxidant, Skin Conditioning)
Good for Dry Skin
Good for Dry Skin
2
A
Glycerin
(Denaturant, Fragrance, Hair Conditioning, Humectant, Oral Care Agent, Oral Health Care Drug, Skin Protecting, Viscosity Decreasing Agent, Perfuming, Solvent)
Good for Dry Skin
Good for Dry Skin
Fungal Acne
Fungal Acne Trigger
1
Bioflavonoids
(Skin Conditioning, Soothing)
9
A
Retinol
(Skin Conditioning)
Bad for Sensitive Skin
Bad for Sensitive Skin
3
B
Polysorbate 20
(Emulsifying, Surfactant)
Fungal Acne
Fungal Acne Trigger
4
A
Phenoxyethanol
(Fragrance, Preservative)
Paraben
Paraben

My Ingredient Notes

No personal ingredient notes yet. Save ingredients to your profile to get good/bad alerts here.

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Key ingredients

Ascorbic Acid (Vitamin C)
Antioxidant, Skin Conditioning
Alcohol Denat.
Astringent
Pentylene Glycol
Skin Conditioning
Propylene Glycol
Humectant, Skin Conditioning
Olea Europaea (Olive) Leaf Extract
Skin Conditioning
Polyporus Umbellatus (Mushroom) Extract
Skin Protecting

Benefits

Good for oily/acne-prone skin

Concerns

Contains paraben
Not fungal acne (malassezia) safe
Retinol — higher EWG
May not suit dry skin
May not suit sensitive skin

EWG flags hazard, not real-world risk — ratings don't account for how much of an ingredient a product contains. Treat these as things to research, not verdicts. How we score →

Ingredients explained

Water
Solvent
Low-hazard ingredient.Read moreShow less
EWG 1 Solvent
Pentylene Glycol
Skin conditioning, Solvent
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A Skin conditioningSolvent
Olea Europaea (Olive) Leaf Extract
Skin conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 Skin conditioning
Zinc Sulfate
Cosmetic astringent, Cosmetic biocide
Low-to-moderate hazard.Read moreShow less
EWG 4 Cosmetic astringentCosmetic biocideOral care agentAntimicrobialAntiplaque
Polyporus Umbellatus (Mushroom) Extract
Skin protecting
Low-hazard ingredient.Read moreShow less
EWG 1 Skin protecting
Bioflavonoids
Skin conditioning, Soothing
Low-hazard ingredient.Read moreShow less
EWG 1 Skin conditioningSoothing
Ascorbic Acid (Vitamin C)
Antioxidant, Fragrance
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A AntioxidantFragrancePh adjusterSkin conditioningBuffering agentMasking Good for Dry Skin
Laureth-4
Antistatic agent, Emulsifying
Potentially comedogenic - can block poresRead moreShow less
EWG 2–3 CIR B Antistatic agentEmulsifyingMaskingSurfactant Bad for Oily Skin
Alcohol Denat.
Antifoaming agent, Antimicrobial
Causes moisture evaporation - prone to dry out skinRead moreShow less
EWG 4 Antifoaming agentAntimicrobialAstringentMaskingSolventViscosity controlling Bad for Dry SkinBad for Sensitive Skin
Propylene Glycol
Fragrance, Humectant
Low-to-moderate hazard.Read moreShow less
EWG 3 CIR B FragranceHumectantSkin-conditioningagent - miscellaneousSolventViscosity decreasing agentSkin conditioningViscosity controlling Good for Dry Skin
Tocopherol (Vitamin E)
Other
Low-hazard ingredient.Read moreShow less
EWG 1 Good for Dry Skin
Arbutin
Antioxidant, Skin conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 AntioxidantSkin conditioning Good for Dry Skin
Glycerin
Denaturant, Fragrance
Low-hazard ingredient.Read moreShow less
EWG 2 CIR A DenaturantFragranceHair conditioningHumectantOral care agentOral health care drugSkin protectingViscosity decreasing agentPerfumingSolvent Good for Dry SkinFungal-acne trigger
Retinol
Skin conditioning
Potentially a skin irritantRead moreShow less
EWG 9 CIR A Skin conditioning Bad for Sensitive Skin
Polysorbate 20
Emulsifying, Surfactant
Low-to-moderate hazard.Read moreShow less
EWG 3 CIR B EmulsifyingSurfactant Fungal-acne trigger
Phenoxyethanol
Fragrance, Preservative
Low-to-moderate hazard.Read moreShow less
EWG 4 CIR A FragrancePreservative Paraben

How to use

How to use

  • 1 Where it fits: Apply after toner and before moisturiser — thinnest to thickest.
  • 2 Evening: Use at night — start 2–3× a week and build up as your skin tolerates it.
  • 3 Wear SPF the next day: Acids and retinoids increase sun sensitivity — daily sunscreen is a must while using this.

General guidance from this product's category and active ingredients — always follow the directions on the package.

Trust & honesty

Pregnancy & breastfeeding

Contains ingredients some choose to avoid or double-check while pregnant or nursing.

Often avoided
Retinoids (Vitamin A) (Retinol)

Topical retinoids (retinol, retinaldehyde, retinyl esters) are widely advised against in pregnancy as a precaution. The strongest evidence is for ORAL retinoids; topical absorption is low, but most clinicians err on the side of caution.

This is general information, not medical advice. Pregnancy guidance varies and depends on concentration and your individual situation — always check with your doctor, midwife or pharmacist. How we flag this.

Effective levels — general guide

The concentrations these actives are typically effective at in research — not a measurement of this product.

Retinoids (Vitamin A) 0.01–1%

Most studied between 0.1% and 1%. Higher is not automatically better — irritation climbs with dose, so a well-formulated lower strength is often the sweet spot.

Retinol

Vitamin C (ascorbic) 5–20%

L-ascorbic acid is usually used at 5–20% (around 10–15% is common). Above ~20% adds little and tends to irritate more; it also needs a low pH to work.

Ascorbic Acid (Vitamin C)

INCI lists don't disclose amounts, and we don't claim to know this product's levels — these are the ranges these ingredients are usually effective at, so you can tell a real formula from "fairy-dusting" a marketed active. How we estimate this.

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