Pro-Heal Serum Advance

iS Clinical

Where to buy Possibly in stock

About this product

The iS Clinical Pro-Heal Serum Advance is a serums, essence, ampoule. Our analysis of its 17 ingredients (8 low-risk) rates it Excellent (84/100). Based on its ingredients, it looks well-suited to oily / acne-prone skin.

Vegan-friendly Reef-safe

Summarised from our ingredient analysis — not brand marketing copy.

At a glance

Type
Serums, Essence, Ampoules
Ingredients
17
Low-risk
8
Fragrance
Fragrance-free
Origin
United States

The evidence

Quick Product Notes

Paraben-Free Sulfate-Free Alcohol-Free Silicone-Free EU Allergen-Free Fungal Acne (Malassezia) Safe

Notable Effects & Ingredients

No Notable Effects & Ingredients

Ingredients Related to Skin Types

Good   Bad — tap a skin type to see which ingredients · estimated from ingredient functions
Dry Skin 2/6
Good for dry skin
Glycerin Propylene Glycol
Caution for dry skin
Glycerin Polysorbate 20 Alcohol Denat. Zinc Sulfate Triethanolamine Laureth-4
Oily/Acne-Prone Skin 3/0
Good for oily/acne-prone skin
Alcohol Denat. Zinc Sulfate Retinol
Sensitive Skin 3/7
Good for sensitive skin
Arbutin Bioflavonoids Glycerin
Caution for sensitive skin
Glycerin Propylene Glycol Alcohol Denat. Phenoxyethanol Triethanolamine Retinol Laureth-4

Ingredients list

17 total
Lower hazard (1) Higher hazard (9)
All17 Skin Conditioning10 Fragrance6 Solvent5 Humectant4 Antioxidant3 Emulsifying3 Masking3 Surfactant3
EWG CIR Ingredient Name & Cosmetic Functions Notes
1
Water
(Solvent)
ASCORBIC ACID
(Antioxidant, Buffering, Fragrance, Skin Conditioning)
2
3
B
Laureth-4
(Antistatic Agent, Emulsifying, Masking, Surfactant)
Bad for Oily Skin
Bad for Oily Skin
4
Alcohol Denat.
(Antifoaming Agent, Antimicrobial, Astringent, Masking, Solvent, Viscosity Controlling)
Bad for Dry Skin
Bad for Dry Skin
Bad for Sensitive Skin
Bad for Sensitive Skin
1
A
Pentylene Glycol
(Skin Conditioning, Solvent)
3
B
Propylene Glycol
(Fragrance, Humectant, Skin Conditioningagent Miscellaneous, Solvent, Viscosity Decreasing Agent, Skin Conditioning, Viscosity Controlling)
Good for Dry Skin
Good for Dry Skin
5
B
Triethanolamine
(Fragrance, Ph Adjuster, Emulsifying, Surfactant, Buffering Agent, Masking)
TOCOPHEROL
(Antioxidant, Fragrance, Skin Conditioning)
2
A
Glycerin
(Denaturant, Fragrance, Hair Conditioning, Humectant, Oral Care Agent, Oral Health Care Drug, Skin Protecting, Viscosity Decreasing Agent, Perfuming, Solvent)
Good for Dry Skin
Good for Dry Skin
Fungal Acne
Fungal Acne Trigger
1
Bioflavonoids
(Skin Conditioning, Soothing)
9
A
Retinol
(Skin Conditioning)
Bad for Sensitive Skin
Bad for Sensitive Skin
olea europaea leaf extract
(Perfuming, Skin Conditioning)
4
Zinc Sulfate
(Cosmetic Astringent, Cosmetic Biocide, Oral Care Agent, Antimicrobial, Antiplaque)
Polyporus Umbellatus Extract
(Skin Protecting)
1
Arbutin
(Antioxidant, Skin Conditioning)
Good for Dry Skin
Good for Dry Skin
3
B
Polysorbate 20
(Emulsifying, Surfactant)
Fungal Acne
Fungal Acne Trigger
4
A
Phenoxyethanol
(Fragrance, Preservative)
Paraben
Paraben

My Ingredient Notes

No personal ingredient notes yet. Save ingredients to your profile to get good/bad alerts here.

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Key ingredients

Antioxidants
Shields skin from free radical damage.
Retinoid
Visibly reduces the signs of aging.
Vitamin C
Brightens, evens tone, and supports collagen.
Vitamin E
Protects skin and soothes irritation.
Arbutin
Gently brightens and evens skin tone.

Benefits

BrighteningRestores radiance to dull, tired skin.
Scar HealingImproves the look of marks and scars.
Dark SpotsFades dark spots for even skin tone.
Anti-AgingSoftens lines and helps skin look youthful.
HydratingBoosts hydration and relieves dry, tight skin.
Barrier RepairStrengthen and restore your skin's natural barrier.
Good For Oily SkinBalances oil and helps reduce shine.
Skin TextureSmooths rough patches and refines texture.

Concerns

Contains paraben
Not fungal acne (malassezia) safe
Retinol — higher EWG
May not suit dry skin
May not suit sensitive skin

EWG flags hazard, not real-world risk — ratings don't account for how much of an ingredient a product contains. Treat these as things to research, not verdicts. How we score →

Ingredients explained

Water
Solvent
Low-hazard ingredient.Read moreShow less
EWG 1 Solvent
ASCORBIC ACID
Antioxidant, Buffering
Limited public safety data.Read moreShow less
EWG N/A AntioxidantBufferingFragranceSkin conditioning
Pentylene Glycol
Skin conditioning, Solvent
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A Skin conditioningSolvent
TOCOPHEROL
Antioxidant, Fragrance
Limited public safety data.Read moreShow less
EWG N/A AntioxidantFragranceSkin conditioning
Bioflavonoids
Skin conditioning, Soothing
Low-hazard ingredient.Read moreShow less
EWG 1 Skin conditioningSoothing
olea europaea leaf extract
Perfuming, Skin conditioning
Limited public safety data.Read moreShow less
EWG N/A PerfumingSkin conditioning
Zinc Sulfate
Cosmetic astringent, Cosmetic biocide
Low-to-moderate hazard.Read moreShow less
EWG 4 Cosmetic astringentCosmetic biocideOral care agentAntimicrobialAntiplaque
Polyporus Umbellatus Extract
Skin protecting
Limited public safety data.Read moreShow less
EWG N/A Skin protecting
Laureth-4
Antistatic agent, Emulsifying
Potentially comedogenic - can block poresRead moreShow less
EWG 2–3 CIR B Antistatic agentEmulsifyingMaskingSurfactant Bad for Oily Skin
Alcohol Denat.
Antifoaming agent, Antimicrobial
Causes moisture evaporation - prone to dry out skinRead moreShow less
EWG 4 Antifoaming agentAntimicrobialAstringentMaskingSolventViscosity controlling Bad for Dry SkinBad for Sensitive Skin
Propylene Glycol
Fragrance, Humectant
Low-to-moderate hazard.Read moreShow less
EWG 3 CIR B FragranceHumectantSkin-conditioningagent - miscellaneousSolventViscosity decreasing agentSkin conditioningViscosity controlling Good for Dry Skin
Triethanolamine
Fragrance, Ph adjuster
Moderate-hazard ingredient.Read moreShow less
EWG 5 CIR B FragrancePh adjusterEmulsifyingSurfactantBuffering agentMasking
Glycerin
Denaturant, Fragrance
Low-hazard ingredient.Read moreShow less
EWG 2 CIR A DenaturantFragranceHair conditioningHumectantOral care agentOral health care drugSkin protectingViscosity decreasing agentPerfumingSolvent Good for Dry SkinFungal-acne trigger
Retinol
Skin conditioning
Potentially a skin irritantRead moreShow less
EWG 9 CIR A Skin conditioning Bad for Sensitive Skin
Arbutin
Antioxidant, Skin conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 AntioxidantSkin conditioning Good for Dry Skin
Polysorbate 20
Emulsifying, Surfactant
Low-to-moderate hazard.Read moreShow less
EWG 3 CIR B EmulsifyingSurfactant Fungal-acne trigger
Phenoxyethanol
Fragrance, Preservative
Low-to-moderate hazard.Read moreShow less
EWG 4 CIR A FragrancePreservative Paraben

How to use

How to use

  • 1 Where it fits: Apply after toner and before moisturiser — thinnest to thickest.
  • 2 Evening: Use at night — start 2–3× a week and build up as your skin tolerates it.
  • 3 Wear SPF the next day: Acids and retinoids increase sun sensitivity — daily sunscreen is a must while using this.

General guidance from this product's category and active ingredients — always follow the directions on the package.

Trust & honesty

Pregnancy & breastfeeding

Contains ingredients some choose to avoid or double-check while pregnant or nursing.

Often avoided
Retinoids (Vitamin A) (Retinol)

Topical retinoids (retinol, retinaldehyde, retinyl esters) are widely advised against in pregnancy as a precaution. The strongest evidence is for ORAL retinoids; topical absorption is low, but most clinicians err on the side of caution.

This is general information, not medical advice. Pregnancy guidance varies and depends on concentration and your individual situation — always check with your doctor, midwife or pharmacist. How we flag this.

Effective levels — general guide

The concentrations these actives are typically effective at in research — not a measurement of this product.

Retinoids (Vitamin A) 0.01–1%

Most studied between 0.1% and 1%. Higher is not automatically better — irritation climbs with dose, so a well-formulated lower strength is often the sweet spot.

Retinol

Vitamin C (ascorbic) 5–20%

L-ascorbic acid is usually used at 5–20% (around 10–15% is common). Above ~20% adds little and tends to irritate more; it also needs a low pH to work.

ASCORBIC ACID

INCI lists don't disclose amounts, and we don't claim to know this product's levels — these are the ranges these ingredients are usually effective at, so you can tell a real formula from "fairy-dusting" a marketed active. How we estimate this.

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