Spicule Retinol PDRN Cream
The Mary & May Spicule Retinol PDRN Cream is a moisturizer. Our analysis of its 52 ingredients (44 low-risk) rates it Excellent (98/100). Based on its ingredients, it looks well-suited to oily / acne-prone skin.
The Mary & May Spicule Retinol PDRN Cream is a moisturizer. Our analysis of its 52 ingredients (44 low-risk) rates it Excellent (98/100). Based on its ingredients, it looks well-suited to oily / acne-prone skin.
Summarised from our ingredient analysis — not brand marketing copy.
The evidence
| EWG | CIR | Ingredient Name & Cosmetic Functions | Notes |
|---|---|---|---|
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Water
(Solvent) |
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Methylpropanediol
(Solvent) |
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Glycerin
(Denaturant, Fragrance, Hair Conditioning, Humectant, Oral Care Agent, Oral Health Care Drug, Skin Protecting, Viscosity Decreasing Agent, Perfuming, Solvent) |
Good for Dry Skin
Fungal Acne Trigger
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1,2-Hexanediol
(Solvent) |
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Niacinamide
(Hair Conditioning, Skin Conditioning, Smoothing) |
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Panthenol
(Antistatic Agent, Hair Conditioning, Skin Conditioning) |
Good for Dry Skin
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Caprylic/Capric Triglyceride
(Emollient, Masking, Perfuming, Skin Conditioning, Solvent) |
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Polypropylsilsesquioxane
(Binding Agent, Film Forming) |
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C14-22 Alcohols
(Emulsion Stabilising) |
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Ammonium Acryloyldimethyltaurate/VP Copolymer
(Viscosity Controlling) |
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Glyceryl Stearate
(Emollient, Emulsifying) |
Fungal Acne Trigger
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Cetyl Ethylhexanoate
(Skin Conditioning, Emollient) |
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Vinyldimethicone
(Viscosity Controlling) |
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Macadamia Ternifolia Seed Oil
(Emollient) |
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Brassica Campestris Sterols
(Skin Conditioning, Skin Conditioning Emollient) |
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Polyglyceryl-10 Laurate
(Skin Conditioning, Emulsifying, Surfactant) |
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Acrylates/C10-30 Alkyl Acrylate Crosspolymer
(Emulsion Stabilising, Film Forming, Viscosity Controlling) |
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C12-20 Alkyl Glucoside
(Emulsifying, Surfactant) |
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Arginine
(Fragrance, Hair Conditioning, Skin Conditioning, Antistatic Agent, Masking) |
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Phytosteryl/Behenyl/Octyldodecyl Lauroyl Glutamate
(Skin Conditioning) |
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Cholesterol
(Emulsion Stabilising, Skin Conditioning, Viscosity Increasing Agent, Emollient, Emulsifying, Stabilising, Viscosity Controlling) |
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Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
(Anticaking Agent, Emulsion Stabilising, Opacifying, Suspending Agent Nonsurfactant, Viscosity Increasing Agent) |
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Hydrolyzed Sponge
(Skin Conditioning) |
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Polyisobutene
(Binding Agent, Film Forming, Viscosity Increasing Agent, Binding, Viscosity Controlling) |
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Gardenia Florida Fruit Extract
(Skin Conditioning) |
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TOCOPHEROL
(Antioxidant, Fragrance, Skin Conditioning) |
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Allantoin
(Skin Conditioning, Skin Protecting, Soothing) |
Good for Oily Skin
Good for Sensitive Skin
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Ethylhexylglycerin
(Deodorant, Skin Conditioning) |
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Butyrospermum Parkii Butter
(Skin Conditioning, Viscosity Controlling) |
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Retinol
(Skin Conditioning) |
Bad for Sensitive Skin
|
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Xanthan Gum
(Binding Agent, Emulsion Stabilising, Skin Conditioning, Surfactant Emulsifying Agent, Viscosity Increasing Agent, Binding, Gel Forming, Viscosity Controlling) |
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Hydrogenated Lecithin
(Skin Conditioning, Emulsifying, Surfactant, Suspending Agent Nonsurfactant) |
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Sodium Hyaluronate
(Skin Conditioning, Humectant) |
Good for Dry Skin
|
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Pentaerythrityl Tetra-di-t-butyl Hydroxyhydrocinnamate
(Antioxidant) |
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Adenosine
(Skin Conditioning) |
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Dextrin
(Absorbent, Binding Agent, Bulking Agent, Viscosity Increasing Agent, Binding, Viscosity Controlling) |
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Helianthus Annuus Seed Oil
(Fragrance, Skin Conditioning, Skin Conditioning Emollient) |
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Lauryl Glucoside
(Cleansing, Surfactant) |
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Polyglutamic Acid
(Skin Conditioning) |
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Polyglyceryl-6 Laurate
(Emulsifying) |
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Disodium EDTA
(Chelating Agent, Viscosity Controlling) |
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Ceramide NP
(Hair Conditioning, Skin Conditioning) |
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Caprylyl/Capryl Glucoside
(Cleansing, Foaming, Surfactant) |
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Sorbitan Oleate
(Fragrance, Emulsifying, Surfactant) |
Bad for Oily Skin
Fungal Acne Trigger
|
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Myristyl Glucoside
(Cleansing) |
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Stearic Acid
(Fragrance, Sufactant, Emulsifying, Surfactantsurfactant Cleansing Agent Is Included As A Function For The Soap Form Of Stearic Acid., Emulsion Stabilising, Masking, Refatting) |
Bad for Oily Skin
Fungal Acne Trigger
|
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Benzotriazolyl Dodecyl p-Cresol
(Uv Absorber) |
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Glyceryl Acrylate/Acrylic Acid Copolymer
(Humectant, Viscosity Controlling) |
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Oleic Acid
(Fragrance, Sufactantsurfactant Cleansing Agent Is Included As A Function For The Soap Form Of Oleic Acid., Emollient, Emulsifying) |
Fungal Acne Trigger
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PVM/MA Copolymer
(Antistatic Agent, Binding, Emulsion Stabilising, Film Forming, Hair Fixing, Viscosity Controlling) |
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Beta-Carotene
(Skin Conditioning) |
Good for Dry Skin
|
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Sodium DNA
(Skin Conditioning) |
No personal ingredient notes yet. Save ingredients to your profile to get good/bad alerts here.
EWG flags hazard, not real-world risk — ratings don't account for how much of an ingredient a product contains. Treat these as things to research, not verdicts. How we score →
How to use
General guidance from this product's category and active ingredients — always follow the directions on the package.
Trust & honesty
Contains ingredients some choose to avoid or double-check while pregnant or nursing.
Topical retinoids (retinol, retinaldehyde, retinyl esters) are widely advised against in pregnancy as a precaution. The strongest evidence is for ORAL retinoids; topical absorption is low, but most clinicians err on the side of caution.
This is general information, not medical advice. Pregnancy guidance varies and depends on concentration and your individual situation — always check with your doctor, midwife or pharmacist. How we flag this.
The concentrations these actives are typically effective at in research — not a measurement of this product.
Most studied between 0.1% and 1%. Higher is not automatically better — irritation climbs with dose, so a well-formulated lower strength is often the sweet spot.
Retinol
Most research uses 2–5%; some formulas go to 10%. Very high levels can cause flushing in sensitive skin.
Niacinamide
INCI lists don't disclose amounts, and we don't claim to know this product's levels — these are the ranges these ingredients are usually effective at, so you can tell a real formula from "fairy-dusting" a marketed active. How we estimate this.
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