25% Vitamin C + Glutathione Clinical Serum

Paula's Choice

Where to buy Possibly in stock

About this product

The Paula's Choice 25% Vitamin C + Glutathione Clinical Serum is a serums, essence, ampoule. Our analysis of its 41 ingredients (34 low-risk) rates it Excellent (99/100). Based on its ingredients, it looks well-suited to dry skin.

Vegan-friendly Reef-safe

Summarised from our ingredient analysis — not brand marketing copy.

At a glance

Type
Serums, Essence, Ampoules
Ingredients
41
Low-risk
34
Fragrance
Fragrance-free
Origin
United States

The evidence

Quick Product Notes

Paraben-Free Sulfate-Free Alcohol-Free Silicone-Free EU Allergen-Free Fungal Acne (Malassezia) Safe

Notable Effects & Ingredients

No Notable Effects & Ingredients

Ingredients Related to Skin Types

Good   Bad — tap a skin type to see which ingredients · estimated from ingredient functions
Dry Skin 14/9
Good for dry skin
Glucose Mannitol Cetyl Alcohol Caprylic/Capric Triglyceride Caprylyl Glycol Sodium PCA Sodium Hyaluronate Glycerin Coco-Caprylate/Caprate Trehalose Polyglyceryl-6 Polyricinoleate Polyquaternium-51 Dimethicone Urea
Caution for dry skin
Cetyl Alcohol Sorbitan Isostearate Xanthan Gum Glycerin Polyglyceryl-6 Polyricinoleate Hexylene Glycol Hydrogenated Lecithin Polysorbate 60 Silica
Oily/Acne-Prone Skin No data
Sensitive Skin 6/9
Good for sensitive skin
Vanilla Planifolia Fruit Extract Ascorbyl Glucoside Ergothioneine Glycerin Tetrahexyldecyl Ascorbate Dimethicone
Caution for sensitive skin
Glutathione Mannitol Cetyl Alcohol Sodium Citrate Caprylic/Capric Triglyceride Glycerin Triacetin Hexylene Glycol Phenoxyethanol

Ingredients list

41 total
Lower hazard (1) Higher hazard (4)
All41 Skin Conditioning30 Humectant14 Fragrance9 Solvent6 Emollient6 Emulsion Stabilising6 Surfactant6 Emulsifying6
EWG CIR Ingredient Name & Cosmetic Functions Notes
1
Water
(Solvent)
1
Tetrahexyldecyl Ascorbate
(Antioxidant, Skin Conditioning)
3
A
Dimethicone
(Antifoaming Agent, Skin Protecting, Emollient, Skin Conditioning)
Silicone
Silicone
2
A
Glycerin
(Denaturant, Fragrance, Hair Conditioning, Humectant, Oral Care Agent, Oral Health Care Drug, Skin Protecting, Viscosity Decreasing Agent, Perfuming, Solvent)
Good for Dry Skin
Good for Dry Skin
Fungal Acne
Fungal Acne Trigger
1
C9-12 Alkane
(Solvent)
1
Ascorbyl Glucoside
(Antioxidant)
1
2
A
Silica
(Abrasive, Absorbent, Anticaking Agent, Bulking Agent, Opacifying, Viscosity Controlling)
Pyrus Malus Fruit Extract
(Skin Conditioning)
2
A
Hydrogenated Lecithin
(Skin Conditioning, Emulsifying, Surfactant, Suspending Agent Nonsurfactant)
1
Polyglyceryl-6 Polyricinoleate
(Skin Conditioning, Emollient, Emulsifying, Surfactant)
1
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
(Emulsion Stabilising, Film Forming, Viscosity Controlling)
1
A
Xanthan Gum
(Binding Agent, Emulsion Stabilising, Skin Conditioning, Surfactant Emulsifying Agent, Viscosity Increasing Agent, Binding, Gel Forming, Viscosity Controlling)
Oryza Sativa Bran Extract
(Skin Conditioning, Skin Protecting)
1
Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
(Emulsion Stabilising, Viscosity Controlling)
1
A
Cetyl Alcohol
(Emulsion Stabilising, Fragrance, Opacifying, Emulsifying, Surfactant, Foam Boosting, Viscosity Increasing Agent, Emollient, Masking, Viscosity Controlling)
1
A
Caprylyl Glycol
(Hair Conditioning, Skin Conditioning, Emollient, Humectant)
1
Lysine Carboxymethyl Cysteinate
(Skin Conditioning)
1
B
Coco-Caprylate/Caprate
(Emollient, Skin Conditioning)
TOCOPHEROL
(Antioxidant, Fragrance, Skin Conditioning)
1
Glutathione
(Fragrance, Reducing)
1
A
Sodium Citrate
(Ph Adjuster, Buffering Agent, Chelating, Masking)
1
Sodium Phytate
(Chelating Agent, Oral Care Agent)
1
A
Hexylene Glycol
(Fragrance, Solvent, Viscosity Decreasing Agent, Emulsifying, Perfuming, Skin Conditioning, Surfactant)
1
A
Ethylhexylglycerin
(Deodorant, Skin Conditioning)
Helianthus Annuus Seed Extract
(Skin Conditioning)
3
A
Urea
(Buffering Agent, Humectant, Antistatic Agent, Skin Conditioning)
1
Mannitol
(Binding Agent, Flavoring Agent, Humectant, Binding, Masking, Moisturising, Skin Conditioning)
1
A
Caprylic/Capric Triglyceride
(Emollient, Masking, Perfuming, Skin Conditioning, Solvent)
1
B
Sodium PCA
(Hair Conditioning, Humectant, Antistatic Agent, Skin Conditioning)
Good for Dry Skin
Good for Dry Skin
rosmarinus officinalis leaf extract
(Antimicrobial, Fragrance, Skin Conditioning)
3
B
Polysorbate 60
(Emulsifying, Surfactant)
Fungal Acne
Fungal Acne Trigger
1
A
Sorbitan Isostearate
(Emulsifying, Surfactant)
1
A
Trehalose
(Flavoring Agent, Humectant, Moisturising)
ASCORBIC ACID
(Antioxidant, Buffering, Fragrance, Skin Conditioning)
1
A
Glucose
(Flavoring Agent, Humectant, Skin Conditioning Agent Miscellaneous)
1
Vanilla Planifolia Fruit Extract
(Skin Conditioning, Skin Protecting, Smoothing)
1
Polyquaternium-51
(Film Forming, Humectant, Skin Conditioning)
1
Ergothioneine
(Antioxidant)
1
A
Triacetin
(Cosmetic Biocide, Fragrance, Plasticizer, Solvent, Antimicrobial, Film Forming, Masking)
1
A
Sodium Hyaluronate
(Skin Conditioning, Humectant)
Good for Dry Skin
Good for Dry Skin
4
A
Phenoxyethanol
(Fragrance, Preservative)
Paraben
Paraben

My Ingredient Notes

No personal ingredient notes yet. Save ingredients to your profile to get good/bad alerts here.

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Key ingredients

Tetrahexyldecyl Ascorbate
Antioxidant, Skin Conditioning
Dimethicone
Skin Protecting, Emollient
Glycerin
Humectant, Skin Protecting
Ascorbyl Glucoside
Antioxidant
Pyrus Malus Fruit Extract
Skin Conditioning
Hydrogenated Lecithin
Skin Conditioning

Benefits

Good for dry skin

Concerns

Contains paraben
Contains silicone
Not fungal acne (malassezia) safe
May not suit sensitive skin

Ingredients explained

Water
Solvent
Low-hazard ingredient.Read moreShow less
EWG 1 Solvent
Tetrahexyldecyl Ascorbate
Antioxidant, Skin conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 AntioxidantSkin conditioning
C9-12 Alkane
Solvent
Low-hazard ingredient.Read moreShow less
EWG 1 Solvent
Ascorbyl Glucoside
Antioxidant
Low-hazard ingredient.Read moreShow less
EWG 1 Antioxidant
Silica
Abrasive, Absorbent
Low-hazard ingredient.Read moreShow less
EWG 1–2 CIR A AbrasiveAbsorbentAnticaking agentBulking agentOpacifyingViscosity controlling
Pyrus Malus Fruit Extract
Skin conditioning
Limited public safety data.Read moreShow less
EWG N/A Skin conditioning
Hydrogenated Lecithin
Skin conditioning, Emulsifying
Low-hazard ingredient.Read moreShow less
EWG 2 CIR A Skin conditioningEmulsifyingSurfactantSuspending agent- nonsurfactant
Polyglyceryl-6 Polyricinoleate
Skin conditioning, Emollient
Low-hazard ingredient.Read moreShow less
EWG 1 Skin conditioningEmollientEmulsifyingSurfactant
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Emulsion stabilising, Film forming
Low-hazard ingredient.Read moreShow less
EWG 1 Emulsion stabilisingFilm formingViscosity controlling
Xanthan Gum
Binding agent, Emulsion stabilising
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A Binding agentEmulsion stabilisingSkin conditioningSurfactant -emulsifying agentViscosity increasing agentBindingGel formingViscosity controlling
Oryza Sativa Bran Extract
Skin conditioning, Skin protecting
Limited public safety data.Read moreShow less
EWG N/A Skin conditioningSkin protecting
Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Emulsion stabilising, Viscosity controlling
Low-hazard ingredient.Read moreShow less
EWG 1 Emulsion stabilisingViscosity controlling
Cetyl Alcohol
Emulsion stabilising, Fragrance
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A Emulsion stabilisingFragranceOpacifyingEmulsifyingSurfactantFoam boostingViscosity increasing agentEmollientMaskingViscosity controlling
Caprylyl Glycol
Hair conditioning, Skin conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A Hair conditioningSkin conditioningEmollientHumectant
Lysine Carboxymethyl Cysteinate
Skin conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 Skin conditioning
+ 20 more — see the full ingredients list above
Dimethicone
Antifoaming agent, Skin protecting
Low-to-moderate hazard.Read moreShow less
EWG 3 CIR A Antifoaming agentSkin protectingEmollientSkin conditioning Silicone
Glycerin
Denaturant, Fragrance
Low-hazard ingredient.Read moreShow less
EWG 2 CIR A DenaturantFragranceHair conditioningHumectantOral care agentOral health care drugSkin protectingViscosity decreasing agentPerfumingSolvent Good for Dry SkinFungal-acne trigger
Sodium PCA
Hair conditioning, Humectant
Low-hazard ingredient.Read moreShow less
EWG 1 CIR B Hair conditioningHumectantAntistatic agentSkin conditioning Good for Dry Skin
Polysorbate 60
Emulsifying, Surfactant
Low-to-moderate hazard.Read moreShow less
EWG 3 CIR B EmulsifyingSurfactant Fungal-acne trigger
Sodium Hyaluronate
Skin conditioning, Humectant
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A Skin conditioningHumectant Good for Dry Skin
Phenoxyethanol
Fragrance, Preservative
Low-to-moderate hazard.Read moreShow less
EWG 4 CIR A FragrancePreservative Paraben

How to use

How to use

  • 1 Where it fits: Apply after toner and before moisturiser — thinnest to thickest.
  • 2 Morning works well: Antioxidants like vitamin C pair well with daytime use under sunscreen.

General guidance from this product's category and active ingredients — always follow the directions on the package.

Trust & honesty

Officially notified as a cosmetic in Malaysia (NPRA). Government registration record.

Effective levels — general guide

The concentrations these actives are typically effective at in research — not a measurement of this product.

Vitamin C (ascorbic) 5–20%

L-ascorbic acid is usually used at 5–20% (around 10–15% is common). Above ~20% adds little and tends to irritate more; it also needs a low pH to work.

Tetrahexyldecyl Ascorbate, Ascorbyl Glucoside, ASCORBIC ACID

INCI lists don't disclose amounts, and we don't claim to know this product's levels — these are the ranges these ingredients are usually effective at, so you can tell a real formula from "fairy-dusting" a marketed active. How we estimate this.

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