Essential Fx Acyl-Glutathione Deep Crease Serum

Perricone MD

Essential Fx Acyl-Glutathione Deep Crease Serum

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About this product

The Perricone MD Essential Fx Acyl-Glutathione Deep Crease Serum is a serums, essence, ampoule. Our analysis of its 45 ingredients (30 low-risk) rates it Excellent (91/100). Based on its ingredients, it looks well-suited to dry skin. Heads up: it contains fragrance, which can irritate sensitive or reactive skin.

Vegan-friendly Reef-safe

Summarised from our ingredient analysis — not brand marketing copy.

At a glance

Type
Serums, Essence, Ampoules
Ingredients
45
Low-risk
30
Fragrance
Contains fragrance
Origin
United States

The evidence

Quick Product Notes

Paraben-Free Sulfate-Free Alcohol-Free Silicone-Free EU Allergen-Free Fungal Acne (Malassezia) Safe

Notable Effects & Ingredients

No Notable Effects & Ingredients

Ingredients Related to Skin Types

Good   Bad — tap a skin type to see which ingredients · estimated from ingredient functions
Dry Skin 14/2
Good for dry skin
Macadamia Ternifolia Seed Oil Anhydroxylitol Squalane Acetyl Hexapeptide-8 Xylitol Xylitylglucoside Salvia Hispanica Seed Oil Caprylic/Capric Triglyceride Caprylyl Glycol Sodium Hyaluronate Hydrogenated Polyisobutene Hydrolyzed Pea Protein Dimethicone Lactic Acid
Caution for dry skin
Xanthan Gum Caprylyl/Capryl Glucoside
Oily/Acne-Prone Skin No data
Sensitive Skin 4/13
Good for sensitive skin
Tetrahexyldecyl Ascorbate Copper Gluconate Dimethicone Alaria Esculenta Extract
Caution for sensitive skin
Glycine Acetic Acid Caprylic/Capric Triglyceride Proline Sodium Benzoate Potassium Sorbate Lactic Acid Phenoxyethanol Linalool Benzyl Alcohol Citronellol Limonene Hydroxycitronellal

Ingredients list

45 total
Lower hazard (1) Higher hazard (7)
All45 Skin Conditioning37 Fragrance13 Humectant8 Masking7 Emollient7 Hair Conditioning7 Perfuming5 Solvent5
EWG CIR Ingredient Name & Cosmetic Functions Notes
1
Water
(Solvent)
1
Propanediol
(Solvent, Viscosity Decreasing Agent, Viscosity Controlling)
1
A
Squalane
(Emollient, Hair Conditioning, Refatting, Skin Conditioning)
1
A
Hydrogenated Polyisobutene
(Skin Conditioning, Emollient, Viscosity Increasing Agent, Viscosity Controlling)
S-Palmitoylglutathione
(Antioxidant)
3
A
Dimethicone
(Antifoaming Agent, Skin Protecting, Emollient, Skin Conditioning)
Silicone
Silicone
1
Macadamia Ternifolia Seed Oil
(Emollient)
1
Xylitylglucoside
(Humectant, Skin Conditioning)
1
Tetrahexyldecyl Ascorbate
(Antioxidant, Skin Conditioning)
1
A
Caprylic/Capric Triglyceride
(Emollient, Masking, Perfuming, Skin Conditioning, Solvent)
1
Anhydroxylitol
(Humectant, Skin Conditioning)
4
A
Phenoxyethanol
(Fragrance, Preservative)
Paraben
Paraben
4
Dimethyl MEA
(Ph Adjuster, Buffering Agent)
4
B
Lactic Acid
(Exfoliant, Fragrance, Humectant, Ph Adjuster, Skin Conditioning Agent Humectant, Skin Conditioning, Buffering Agent)
Bad for Sensitive Skin
Bad for Sensitive Skin
1
Xylitol
(Flavoring Agent, Humectant, Skin Conditioning)
1
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
(Emulsion Stabilising, Film Forming, Viscosity Controlling)
1
A
Caprylyl Glycol
(Hair Conditioning, Skin Conditioning, Emollient, Humectant)
1
Caprylyl/Capryl Glucoside
(Cleansing, Foaming, Surfactant)
1
A
Xanthan Gum
(Binding Agent, Emulsion Stabilising, Skin Conditioning, Surfactant Emulsifying Agent, Viscosity Increasing Agent, Binding, Gel Forming, Viscosity Controlling)
1
A
Hydrolyzed Rice Protein
(Hair Conditioning, Skin Conditioning, Antistatic Agent)
PARFUM
(Fragrance, Perfuming)
Linum Usitatissimum Seed Oil
(Perfuming, Skin Conditioning)
1
Salvia Hispanica Seed Oil
(Moisturising, Skin Conditioning)
TOCOPHEROL
(Antioxidant, Fragrance, Skin Conditioning)
1
Hydrolyzed Pea Protein
(Antistatic Agent, Emollient, Hair Conditioning, Skin Conditioning)
1
A
Ethylhexylglycerin
(Deodorant, Skin Conditioning)
1
Tetrasodium Glutamate Diacetate
(Chelating Agent)
Glycine Soja Oil
(Perfuming, Skin Conditioning, Skin Conditioning Emollient)
1
A
Magnesium Aspartate
(Skin Conditioning)
3
Zinc Gluconate
(Cosmetic Biocide, Skin Conditioning, Deodorant)
Alaria Esculenta Extract
(Hair Conditioning, Skin Protecting)
1
A
Glycine
(Buffering Agent, Fragrance, Hair Conditioning, Skin Conditioning Agent Miscellaneous, Antistatic Agent, Skin Conditioning)
Hydrolyzed Sodium Hyaluronate
(Skin Conditioning)
1
A
Proline
(Fragrance, Hair Conditioning, Skin Conditioning)
1
A
Sodium Hyaluronate
(Skin Conditioning, Humectant)
Good for Dry Skin
Good for Dry Skin
5
A
Benzyl Alcohol
(External Analgesic, Fragrance, Oral Health Care Drug, Preservative, Solvent, Viscosity Decreasing Agent, Masking)
Allergens
Allergens
2
Copper Gluconate
(Skin Conditioning, Skin Protecting)
3
A
Potassium Sorbate
(Fragrance, Preservative)
3
A
Sodium Benzoate
(Fragrance, Preservative, Anticorrosive, Masking)
1
A
Acetic Acid
(Fragrance, Ph Adjuster, Buffering Agent, Masking)
1
Acetyl Hexapeptide-8
(Humectant, Skin Conditioning)
5
Citronellol
(Fragrance, Masking)
Allergens
Allergens
7
Hydroxycitronellal
(Fragrance, Masking)
Allergens
Allergens
6
Limonene
(Deodorant, Perfuming, Solvent)
Allergens
Allergens
5
Linalool
(Fragrance, Deodorant, Masking)
Allergens
Allergens

My Ingredient Notes

No personal ingredient notes yet. Save ingredients to your profile to get good/bad alerts here.

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Key ingredients

Squalane
Emollient, Skin Conditioning
Hydrogenated Polyisobutene
Skin Conditioning, Emollient
S-Palmitoylglutathione
Antioxidant
Dimethicone
Skin Protecting, Emollient
Macadamia Ternifolia Seed Oil
Emollient
Xylitylglucoside
Humectant, Skin Conditioning

Benefits

Fungal-acne (Malassezia) safe
Good for dry skin

Concerns

Contains paraben
Contains silicone
Contains eu allergen
Hydroxycitronellal — higher EWG
May not suit sensitive skin

EWG flags hazard, not real-world risk — ratings don't account for how much of an ingredient a product contains. Treat these as things to research, not verdicts. How we score →

Ingredients explained

Water
Solvent
Low-hazard ingredient.Read moreShow less
EWG 1 Solvent
Propanediol
Solvent, Viscosity decreasing agent
Low-hazard ingredient.Read moreShow less
EWG 1 SolventViscosity decreasing agentViscosity controlling
Squalane
Emollient, Hair conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A EmollientHair conditioningRefattingSkin conditioning
Hydrogenated Polyisobutene
Skin conditioning, Emollient
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A Skin conditioningEmollientViscosity increasing agentViscosity controlling
S-Palmitoylglutathione
Antioxidant
Limited public safety data.Read moreShow less
EWG N/A Antioxidant
Macadamia Ternifolia Seed Oil
Emollient
Low-hazard ingredient.Read moreShow less
EWG 1 Emollient
Xylitylglucoside
Humectant, Skin conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 HumectantSkin conditioning
Tetrahexyldecyl Ascorbate
Antioxidant, Skin conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 AntioxidantSkin conditioning
Caprylic/Capric Triglyceride
Emollient, Masking
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A EmollientMaskingPerfumingSkin conditioningSolvent
Anhydroxylitol
Humectant, Skin conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 HumectantSkin conditioning
Dimethyl MEA
Ph adjuster, Buffering agent
Low-to-moderate hazard.Read moreShow less
EWG 4 Ph adjusterBuffering agent
Xylitol
Flavoring agent, Humectant
Low-hazard ingredient.Read moreShow less
EWG 1 Flavoring agentHumectantSkin conditioning
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Emulsion stabilising, Film forming
Low-hazard ingredient.Read moreShow less
EWG 1 Emulsion stabilisingFilm formingViscosity controlling
Caprylyl Glycol
Hair conditioning, Skin conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A Hair conditioningSkin conditioningEmollientHumectant
Caprylyl/Capryl Glucoside
Cleansing, Foaming
Low-hazard ingredient.Read moreShow less
EWG 1 CleansingFoamingSurfactant
+ 21 more — see the full ingredients list above
Dimethicone
Antifoaming agent, Skin protecting
Low-to-moderate hazard.Read moreShow less
EWG 3 CIR A Antifoaming agentSkin protectingEmollientSkin conditioning Silicone
Phenoxyethanol
Fragrance, Preservative
Low-to-moderate hazard.Read moreShow less
EWG 4 CIR A FragrancePreservative Paraben
Lactic Acid
Exfoliant, Fragrance
Skin irritation can occur at high concentrationRead moreShow less
EWG 4 CIR B ExfoliantFragranceHumectantPh adjusterSkin-conditioning agent -humectantSkin conditioningBuffering agent Bad for Sensitive Skin
Sodium Hyaluronate
Skin conditioning, Humectant
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A Skin conditioningHumectant Good for Dry Skin
Benzyl Alcohol
External analgesic, Fragrance
Moderate-hazard ingredient.Read moreShow less
EWG 5 CIR A External analgesicFragranceOral health care drugPreservativeSolventViscosity decreasing agentMasking Allergens
Citronellol
Fragrance, Masking
Moderate-hazard ingredient.Read moreShow less
EWG 5 FragranceMasking Allergens
Hydroxycitronellal
Fragrance, Masking
Higher-hazard ingredient.Read moreShow less
EWG 7 FragranceMasking Allergens
Limonene
Deodorant, Perfuming
Moderate-hazard ingredient.Read moreShow less
EWG 6 DeodorantPerfumingSolvent Allergens
Linalool
Fragrance, Deodorant
Moderate-hazard ingredient.Read moreShow less
EWG 5 FragranceDeodorantMasking Allergens

How to use

How to use

  • 1 Where it fits: Apply after toner and before moisturiser — thinnest to thickest.
  • 2 Evening, start slow: Best in the PM a few times a week to begin with; avoid layering with other strong actives the same night.
  • 3 Wear SPF the next day: Acids and retinoids increase sun sensitivity — daily sunscreen is a must while using this.

General guidance from this product's category and active ingredients — always follow the directions on the package.

Trust & honesty

Effective levels — general guide

The concentrations these actives are typically effective at in research — not a measurement of this product.

Vitamin C (ascorbic) 5–20%

L-ascorbic acid is usually used at 5–20% (around 10–15% is common). Above ~20% adds little and tends to irritate more; it also needs a low pH to work.

Tetrahexyldecyl Ascorbate

AHA (acid exfoliant) 5–10% (OTC)

OTC leave-on AHAs are usually 5–10%. The effect also depends on pH and free-acid value, not the percentage alone.

Lactic Acid

INCI lists don't disclose amounts, and we don't claim to know this product's levels — these are the ranges these ingredients are usually effective at, so you can tell a real formula from "fairy-dusting" a marketed active. How we estimate this.

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